PERSPECTIVES IN PHARMACOLOGY:

Melinda K. Kutzing and Bonnie L. Firestein

Altered Uric Acid Levels and Disease States
J Pharmacol Exp Ther 2008 324: 1-7. Published online September 21, 2007; 10.1124/jpet.107.129031 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Cécile Béguin, David N. Potter, Jennifer A. DiNieri, Thomas A. Munro, Michele R. Richards, Tracie A. Paine, Loren Berry, Zhiyang Zhao, Bryan L. Roth, Wei Xu, Lee-Yuan Liu-Chen, William A. Carlezon, Jr., and Bruce M. Cohen

N-Methylacetamide Analog of Salvinorin A: A Highly Potent and Selective -Opioid Receptor Agonist with Oral Efficacy
J Pharmacol Exp Ther 2008 324: 188-195. Published online October 19, 2007; 10.1124/jpet.107.129023 [Abstract] [Full Text] [PDF] [Data Supplement]   

Amber M. Muehlmann, Brandon D. Brown, and Darragh P. Devine

Pemoline (2-Amino-5-phenyl-1,3-oxazol-4-one)-induced Self-Injurious Behavior: A Rodent Model of Pharmacotherapeutic Efficacy
J Pharmacol Exp Ther 2008 324: 214-223. Published online October 9, 2007; 10.1124/jpet.107.128207 [Abstract] [Full Text] [PDF]  

Marcelo H. Napimoga, Guilherme R. Souza, Thiago M. Cunha, Luiz F. Ferrari, Juliana T. Clemente-Napimoga, Carlos A. Parada, Waldiceu A. Verri, Jr., Fernando Q. Cunha, and Sérgio H. Ferreira

15d-Prostaglandin J₂ Inhibits Inflammatory Hypernociception: Involvement of Peripheral Opioid Receptor
J Pharmacol Exp Ther 2008 324: 313-321. Published online October 10, 2007; 10.1124/jpet.107.126045 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Crisanto S. Escano, Jr., Lindsay B. Keever, Alexander A. Gutweiler, and Bradley T. Andresen

Angiotensin II Activates Extracellular Signal-Regulated Kinase Independently of Receptor Tyrosine Kinases in Renal Smooth Muscle Cells: Implications for Blood Pressure Regulation
J Pharmacol Exp Ther 2008 324: 34-42. Published online October 2, 2007; 10.1124/jpet.107.126300 [Abstract] [Full Text] [PDF]  

Vlad Ciobotaru, Michèle Heimburger, Liliane Louedec, Christophe Heymes, Renée Ventura-Clapier, Pierre Bedossa, Brigitte Escoubet, Jean-Baptiste Michel, Jean-Jacques Mercadier, and Damien Logeart

Effect of Long-Term Heart Rate Reduction by I_f Current Inhibition on Pressure Overload-Induced Heart Failure in Rats
J Pharmacol Exp Ther 2008 324: 43-49. Published online September 27, 2007; 10.1124/jpet.107.130237 [Abstract] [Full Text] [PDF]  

Jian Zhang and Abdel A. Abdel-Rahman

Inhibition of Nischarin Expression Attenuates Rilmenidine-Evoked Hypotension and Phosphorylated Extracellular Signal-Regulated Kinase 1/2 Production in the Rostral Ventrolateral Medulla of Rats
J Pharmacol Exp Ther 2008 324: 72-78. Published online October 16, 2007; 10.1124/jpet.107.129049 [Abstract] [Full Text] [PDF]  

Noha Nassar and Abdel A. Abdel-Rahman

Brainstem Phosphorylated Extracellular Signal-Regulated Kinase 1/2-Nitric-Oxide Synthase Signaling Mediates the Adenosine A_2A-Dependent Hypotensive Action of Clonidine in Conscious Aortic Barodenervated Rats
J Pharmacol Exp Ther 2008 324: 79-85. Published online October 12, 2007; 10.1124/jpet.107.129692 [Abstract] [Full Text] [PDF]  

Kyoung-Han Kim, Gavin Y. Oudit, and Peter H. Backx

Erythropoietin Protects against Doxorubicin-Induced Cardiomyopathy via a Phosphatidylinositol 3-Kinase-Dependent Pathway
J Pharmacol Exp Ther 2008 324: 160-169. Published online October 10, 2007; 10.1124/jpet.107.125773 [Abstract] [Full Text] [PDF]  

Tina C. Wan, Zhi-Dong Ge, Akihito Tampo, Yasushi Mio, Martin W. Bienengraeber, W. Ross Tracey, Garrett J. Gross, Wai-Meng Kwok, and John A. Auchampach

The A₃ Adenosine Receptor Agonist CP-532,903 [N⁶-(2,5-Dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] Protects against Myocardial Ischemia/Reperfusion Injury via the Sarcolemmal ATP-Sensitive Potassium Channel
J Pharmacol Exp Ther 2008 324: 234-243. Published online September 28, 2007; 10.1124/jpet.107.127480 [Abstract] [Full Text] [PDF]  

Fan Jiang, Nancy Guo, and Gregory J. Dusting

Modulation of Nicotinamide Adenine Dinucleotide Phosphate Oxidase Expression and Function by 3',4'-Dihydroxyflavonol in Phagocytic and Vascular Cells
J Pharmacol Exp Ther 2008 324: 261-269. Published online October 4, 2007; 10.1124/jpet.107.131433 [Abstract] [Full Text] [PDF] [Data Supplement]   

Bin Liu, Mei Han, and Jin-Kun Wen

Acetylbritannilactone Inhibits Neointimal Hyperplasia after Balloon Injury of Rat Artery by Suppressing Nuclear Factor-B Activation
J Pharmacol Exp Ther 2008 324: 292-298. Published online October 2, 2007; 10.1124/jpet.107.127407 [Abstract] [Full Text] [PDF]  

Christopher P. Regan, Laszlo Kiss, Gary L. Stump, Charles J. McIntyre, Douglas C. Beshore, Nigel J. Liverton, Christopher J. Dinsmore, and Joseph J. Lynch, Jr.

Atrial Antifibrillatory Effects of Structurally Distinct I_Kur Blockers 3-[(Dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-Phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in Dogs with Underlying Heart Failure
J Pharmacol Exp Ther 2008 324: 322-330. Published online October 29, 2007; 10.1124/jpet.107.127654 [Abstract] [Full Text] [PDF]  

Jennifer Lawrence, DaLiao Xiao, Qin Xue, Maryam Rejali, Shumei Yang, and Lubo Zhang

Prenatal Nicotine Exposure Increases Heart Susceptibility to Ischemia/Reperfusion Injury in Adult Offspring
J Pharmacol Exp Ther 2008 324: 331-341. Published online October 18, 2007; 10.1124/jpet.107.132175 [Abstract] [Full Text] [PDF]  

Mahmoud M. El-Mas, Ming Fan, and Abdel A. Abdel-Rahman

Endotoxemia-Mediated Induction of Cardiac Inducible Nitric-Oxide Synthase Expression Accounts for the Hypotensive Effect of Ethanol in Female Rats
J Pharmacol Exp Ther 2008 324: 368-375. Published online October 9, 2007; 10.1124/jpet.107.127498 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Jin-Ran Chen, Kartik Shankar, Shanmugam Nagarajan, Thomas M. Badger, and Martin J. J. Ronis

Protective Effects of Estradiol on Ethanol-Induced Bone Loss Involve Inhibition of Reactive Oxygen Species Generation in Osteoblasts and Downstream Activation of the Extracellular Signal-Regulated Kinase/Signal Transducer and Activator of Transcription 3/Receptor Activator of Nuclear Factor-B Ligand Signaling Cascade
J Pharmacol Exp Ther 2008 324: 50-59. Published online October 4, 2007; 10.1124/jpet.107.130351 [Abstract] [Full Text] [PDF]  

Andrea Straßer, Birgit Striegl, Hans-Joachim Wittmann, and Roland Seifert

Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H₁ Receptor Species Isoforms
J Pharmacol Exp Ther 2008 324: 60-71. Published online October 10, 2007; 10.1124/jpet.107.129601 [Abstract] [Full Text] [PDF]  

Tsuneo Ishizuka, Jennifer Cheng, Harpreet Singh, Marco D. Vitto, Vijay L. Manthati, John R. Falck, and Michal Laniado-Schwartzman

20-Hydroxyeicosatetraenoic Acid Stimulates Nuclear Factor-B Activation and the Production of Inflammatory Cytokines in Human Endothelial Cells
J Pharmacol Exp Ther 2008 324: 103-110. Published online October 18, 2007; 10.1124/jpet.107.130336 [Abstract] [Full Text] [PDF]  

Gregory W. Sawyer, Frederick J. Ehlert, and Crystal A. Shults

Cysteine Pairs in the Third Intracellular Loop of the Muscarinic M₁ Acetylcholine Receptor Play a Role in Agonist-Induced Internalization
J Pharmacol Exp Ther 2008 324: 196-205. Published online May 31, 2007; 10.1124/jpet.107.123695 [Abstract] [Full Text] [PDF] [Erratum]   

Simone G. Sala, Úrsula Muñoz, Fernando Bartolomé, Félix Bermejo, and Ángeles Martín-Requero

HMG-CoA Reductase Inhibitor Simvastatin Inhibits Cell Cycle Progression at the G₁/S Checkpoint in Immortalized Lymphocytes from Alzheimer's Disease Patients Independently of Cholesterol-Lowering Effects
J Pharmacol Exp Ther 2008 324: 352-359. Published online October 10, 2007; 10.1124/jpet.107.128959 [Abstract] [Full Text] [PDF]  

Tai Du, Gulay Filiz, Aphrodite Caragounis, Peter J. Crouch, and Anthony R. White

Clioquinol Promotes Cancer Cell Toxicity through Tumor Necrosis Factor Release from Macrophages
J Pharmacol Exp Ther 2008 324: 360-367. Published online October 16, 2007; 10.1124/jpet.107.130377 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Rosanna Supino, Giovanna Petrangolini, Graziella Pratesi, Monica Tortoreto, Enrica Favini, Laura Dal Bo, Patrizia Casalini, Enrico Radaelli, Anna Cleta Croce, Giovanni Bottiroli, Paola Misiano, Carlo Farina, and Franco Zunino

Antimetastatic Effect of a Small-Molecule Vacuolar H⁺-ATPase Inhibitor in in Vitro and in Vivo Preclinical Studies
J Pharmacol Exp Ther 2008 324: 15-22. Published online October 1, 2007; 10.1124/jpet.107.128587 [Abstract] [Full Text] [PDF]  

Fei Shen, Shaoyou Chu, Aimee K. Bence, Barbara Bailey, Xinjian Xue, Priscilla A. Erickson, Marshall H. Montrose, William T. Beck, and Leonard C. Erickson

Quantitation of Doxorubicin Uptake, Efflux, and Modulation of Multidrug Resistance (MDR) in MDR Human Cancer Cells
J Pharmacol Exp Ther 2008 324: 95-102. Published online October 18, 2007; 10.1124/jpet.107.127704 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

B. Ganesh Bhat, Natilie Hosea, Andrea Fanjul, Jocelyn Herrera, Justin Chapman, Fred Thalacker, Paul M. Stewart, and Paul A. Rejto

Demonstration of Proof of Mechanism and Pharmacokinetics and Pharmacodynamic Relationship with 4'-Cyano-biphenyl-4-sulfonic Acid (6-Amino-pyridin-2-yl)-amide (PF-915275), an Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1, in Cynomolgus Monkeys
J Pharmacol Exp Ther 2008 324: 299-305. Published online October 5, 2007; 10.1124/jpet.107.128280 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Carolin Daniel, Nico A. Sartory, Nadine Zahn, Heinfried H. Radeke, and Jürgen M. Stein

Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1/Th17 to a Th2 and Regulatory T Cell Profile
J Pharmacol Exp Ther 2008 324: 23-33. Published online October 2, 2007; 10.1124/jpet.107.127209 [Abstract] [Full Text] [PDF]  

Lawrence H. Lu, Dong-Jin Oh, Belda Dursun, Zhibin He, Thomas S. Hoke, Sarah Faubel, and Charles L. Edelstein

Increased Macrophage Infiltration and Fractalkine Expression in Cisplatin-Induced Acute Renal Failure in Mice
J Pharmacol Exp Ther 2008 324: 111-117. Published online October 11, 2007; 10.1124/jpet.107.130161 [Abstract] [Full Text] [PDF]  

Hai-Lei Zhu, Keith L. Brain, Manami Aishima, Atsushi Shibata, John S. Young, Katsuo Sueishi, and Noriyoshi Teramoto

Actions of Two Main Metabolites of Propiverine (M-1 and M-2) on Voltage-Dependent L-Type Ca²⁺ Currents and Ca²⁺ Transients in Murine Urinary Bladder Myocytes
J Pharmacol Exp Ther 2008 324: 118-127. Published online October 10, 2007; 10.1124/jpet.107.130021 [Abstract] [Full Text] [PDF] [Data Supplement]   

Elizabeth Burcher, Fei Shang, Fiona J. Warner, Qin Du, David Z. Lubowski, Denis W. King, and Lu Liu

Tachykinin NK₂ Receptor and Functional Mechanisms in Human Colon: Changes with Indomethacin and in Diverticular Disease and Ulcerative Colitis
J Pharmacol Exp Ther 2008 324: 170-178. Published online October 24, 2007; 10.1124/jpet.107.130385 [Abstract] [Full Text] [PDF]  

Richard G. Sturton, Alexandre Trifilieff, Andrew G. Nicholson, and Peter J. Barnes

Pharmacological Characterization of Indacaterol, a Novel Once Daily Inhaled β₂ Adrenoceptor Agonist, on Small Airways in Human and Rat Precision-Cut Lung Slices
J Pharmacol Exp Ther 2008 324: 270-275. Published online October 4, 2007; 10.1124/jpet.107.129296 [Abstract] [Full Text] [PDF]  

Jinghai Song, Chu Matsuda, Yasuyuki Kai, Toshirou Nishida, Kiyokazu Nakajima, Tsunekazu Mizushima, Miki Kinoshita, Tokutaro Yasue, Yoshiki Sawa, and Toshinori Ito

A Novel Sphingosine 1-Phosphate Receptor Agonist, 2-Amino-2-propanediol Hydrochloride (KRP-203), Regulates Chronic Colitis in Interleukin-10 Gene-Deficient Mice
J Pharmacol Exp Ther 2008 324: 276-283. Published online September 26, 2007; 10.1124/jpet.106.119172 [Abstract] [Full Text] [PDF]  

Satinder S. Sarang, Svetlana M. Lukyanova, Daniel D. Brown, Brian S. Cummings, Steven R. Gullans, and Rick G. Schnellmann

Identification, Coassembly, and Activity of -Aminobutyric Acid Receptor Subunits in Renal Proximal Tubular Cells
J Pharmacol Exp Ther 2008 324: 376-382. Published online October 24, 2007; 10.1124/jpet.107.129957 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Bettina M. Jensen, Michael A. Beaven, Shoko Iwaki, Dean D. Metcalfe, and Alasdair M. Gilfillan

Concurrent Inhibition of Kit- and FcRI-Mediated Signaling: Coordinated Suppression of Mast Cell Activation
J Pharmacol Exp Ther 2008 324: 128-138. Published online October 9, 2007; 10.1124/jpet.107.125237 [Abstract] [Full Text] [PDF]  

Susan J. Tudhope, Tricia K. Finney-Hayward, Andrew G. Nicholson, Ruth J. Mayer, Mary S. Barnette, Peter J. Barnes, and Louise E. Donnelly

Different Mitogen-Activated Protein Kinase-Dependent Cytokine Responses in Cells of the Monocyte Lineage
J Pharmacol Exp Ther 2008 324: 306-312. Published online October 5, 2007; 10.1124/jpet.107.127670 [Abstract] [Full Text] [PDF] [Data Supplement]   

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Maria Rius, Johanna Hummel-Eisenbeiss, and Dietrich Keppler

ATP-Dependent Transport of Leukotrienes B₄ and C₄ by the Multidrug Resistance Protein ABCC4 (MRP4)
J Pharmacol Exp Ther 2008 324: 86-94. Published online October 24, 2007; 10.1124/jpet.107.131342 [Abstract] [Full Text] [PDF]  

Agnieszka Zielinska, Cheryl F. Lichti, Stacie Bratton, Neil C. Mitchell, Anna Gallus-Zawada, Vi-Huyen Le, Moshe Finel, Grover P. Miller, Anna Radominska-Pandya, and Jeffery H. Moran

Glucuronidation of Monohydroxylated Warfarin Metabolites by Human Liver Microsomes and Human Recombinant UDP-Glucuronosyltransferases
J Pharmacol Exp Ther 2008 324: 139-148. Published online October 5, 2007; 10.1124/jpet.107.129858 [Abstract] [Full Text] [PDF]  

Paul R. Lockman, Vamshi K. Manda, Werner J. Geldenhuys, Rajendar K. Mittapalli, Fancy Thomas, Zaineb Fadhel Albayati, Peter A. Crooks, Linda P. Dwoskin, and David D. Allen

Carrier-Mediated Transport of the Quaternary Ammonium Neuronal Nicotinic Receptor Antagonist N,N'-Dodecylbispicolinium Dibromide at the Blood-Brain Barrier
J Pharmacol Exp Ther 2008 324: 244-250. Published online October 5, 2007; 10.1124/jpet.107.130906 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Hélène Gautier, Jacques Auger, Christian Legros, and Bruno Lapied

Calcium-Activated Potassium Channels in Insect Pacemaker Neurons as Unexpected Target Site for the Novel Fumigant Dimethyl Disulfide
J Pharmacol Exp Ther 2008 324: 149-159. Published online October 17, 2007; 10.1124/jpet.107.128694 [Abstract] [Full Text] [PDF]  

David J. Anderson, William Bunnelle, Bruce Surber, Jia Du, Carol Surowy, Eliane Tribollet, Anouk Marguerat, Daniel Bertrand, and Murali Gopalakrishnan

[³H]A-585539 [(1S,4S)-2,2-Dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a Novel High-Affinity 7 Neuronal Nicotinic Receptor Agonist: Radioligand Binding Characterization to Rat and Human Brain
J Pharmacol Exp Ther 2008 324: 179-187. Published online October 24, 2007; 10.1124/jpet.107.130062 [Abstract] [Full Text] [PDF]  

X. Eric Hu, John A. Wos, Martin E. Dowty, Paula M. Suchanek, Wei Ji, James B. Chambers, Stephen C. Benoit, Deborah J. Clegg, and Ofer Reizes

Small-Molecule Melanin-Concentrating Hormone-1 Receptor Antagonists Require Brain Penetration for Inhibition of Food Intake and Reduction in Body Weight
J Pharmacol Exp Ther 2008 324: 206-213. Published online October 11, 2007; 10.1124/jpet.107.130435 [Abstract] [Full Text] [PDF] [Data Supplement]   

Kwai A. Alier, Jaclyn A. Endicott, Patrick L. Stemkowski, Nicolas Cenac, Laurie Cellars, Kevin Chapman, Patricia Andrade-Gordon, Nathalie Vergnolle, and Peter A. Smith

Intrathecal Administration of Proteinase-Activated Receptor-2 Agonists Produces Hyperalgesia by Exciting the Cell Bodies of Primary Sensory Neurons
J Pharmacol Exp Ther 2008 324: 224-233. Published online October 5, 2007; 10.1124/jpet.107.129171 [Abstract] [Full Text] [PDF]  

Y. Silberman, L. Shi, J. K. Brunso-Bechtold, and J. L. Weiner

Distinct Mechanisms of Ethanol Potentiation of Local and Paracapsular GABAergic Synapses in the Rat Basolateral Amygdala
J Pharmacol Exp Ther 2008 324: 251-260. Published online October 5, 2007; 10.1124/jpet.107.128728 [Abstract] [Full Text] [PDF]  

Juan Guo, Damian J. Williams, Henry L. Puhl, III, and Stephen R. Ikeda

Inhibition of N-Type Calcium Channels by Activation of GPR35, an Orphan Receptor, Heterologously Expressed in Rat Sympathetic Neurons
J Pharmacol Exp Ther 2008 324: 342-351. Published online October 16, 2007; 10.1124/jpet.107.127266 [Abstract] [Full Text] [PDF]  

M. Hajós, C. J. Siok, W. E. Hoffmann, S. Li, and B. Kocsis

Modulation of Hippocampal Theta Oscillation by Histamine H3 Receptors
J Pharmacol Exp Ther 2008 324: 391-398. Published online October 16, 2007; 10.1124/jpet.107.130070 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Mary Lynn Bajt, Anwar Farhood, John J. Lemasters, and Hartmut Jaeschke

Mitochondrial Bax Translocation Accelerates DNA Fragmentation and Cell Necrosis in a Murine Model of Acetaminophen Hepatotoxicity
J Pharmacol Exp Ther 2008 324: 8-14. Published online September 28, 2007; 10.1124/jpet.107.129445 [Abstract] [Full Text] [PDF]  

Gladys V. Erives, Serrine S. Lau, and Terrence J. Monks

Accumulation of Neurotoxic Thioether Metabolites of 3,4-(±)-Methylenedioxymethamphetamine in Rat Brain
J Pharmacol Exp Ther 2008 324: 284-291. Published online September 28, 2007; 10.1124/jpet.107.128785 [Abstract] [Full Text] [PDF]  

Christy C. Bridges, Lucy Joshee, and Rudolfs K. Zalups

Multidrug Resistance Proteins and the Renal Elimination of Inorganic Mercury Mediated by 2,3-Dimercaptopropane-1-Sulfonic Acid and Meso-2,3-dimercaptosuccinic Acid
J Pharmacol Exp Ther 2008 324: 383-390. Published online October 16, 2007; 10.1124/jpet.107.130708 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Thomas S. Otis

Comments on "Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the ₆ GABA_A Receptor Subunit"
J Pharmacol Exp Ther 2008 324: 399-400. [Full Text] [PDF]  

C. Fernando Valenzuela, Richard A. Radcliffe, Paolo Botta, and Manuel Mameli

Response to Comment on "Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the ₆ GABA_A Receptor Subunit"
J Pharmacol Exp Ther 2008 324: 401-403. [Full Text] [PDF]  

C. Di Serio, S. Pellerito, and F. Tarantini

Comments on "Blockade of Angiogenesis by Small Molecule Antagonists to Protease-Activated Receptor-1: Association with Endothelial Cell Growth Suppression and Induction of Apoptosis"
J Pharmacol Exp Ther 2008 324: 404-405. [Full Text] [PDF]  

N. E. Tsopanoglou and M. E. Maragoudakis

Response to Comments on "Blockage of Angiogenesis by Small Molecule Antagonists to Protease-Activated Receptor-1: Association with Endothelial Cell Growth Suppression and Induction of Apoptosis"
J Pharmacol Exp Ther 2008 324: 406-407. [Full Text] [PDF]  

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