PERSPECTIVES IN PHARMACOLOGY:

A. Elizabeth Linder, Wei Ni, Jessica L. Diaz, Theodora Szasz, Robert Burnett, and Stephanie W. Watts

Serotonin (5-HT) in Veins: Not All in Vain
J Pharmacol Exp Ther 2007 323: 415-421. Published online August 1, 2007; 10.1124/jpet.107.122630 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Glenn R. Valdez, Donna M. Platt, James K. Rowlett, Daniela Rüedi-Bettschen, and Roger D. Spealman

Agonist-Induced Reinstatement of Cocaine Seeking in Squirrel Monkeys: A Role for Opioid and Stress-Related Mechanisms
J Pharmacol Exp Ther 2007 323: 525-533. Published online August 16, 2007; 10.1124/jpet.107.125484 [Abstract] [Full Text] [PDF]  

Gregory T. Collins and James H. Woods

Drug and Reinforcement History as Determinants of the Response-Maintaining Effects of Quinpirole in the Rat
J Pharmacol Exp Ther 2007 323: 599-605. Published online August 3, 2007; 10.1124/jpet.107.123042 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Vladimir V. Shuvaev, Samira Tliba, Marian Nakada, Steven M. Albelda, and Vladimir R. Muzykantov

Platelet-Endothelial Cell Adhesion Molecule-1-Directed Endothelial Targeting of Superoxide Dismutase Alleviates Oxidative Stress Caused by Either Extracellular or Intracellular Superoxide
J Pharmacol Exp Ther 2007 323: 450-457. Published online August 21, 2007; 10.1124/jpet.107.127126 [Abstract] [Full Text] [PDF]  

Marie-Thérèse Bawolak, Lajos Gera, Guillaume Morissette, John M. Stewart, and François Marceau

B-9972 (D-Arg-[Hyp³,Igl⁵,Oic⁷,Igl⁸]-bradykinin) Is an Inactivation-Resistant Agonist of the Bradykinin B₂ Receptor Derived from the Peptide Antagonist B-9430 (D-Arg-[Hyp³,Igl⁵,D-Igl⁷,Oic⁸]-bradykinin): Pharmacologic Profile and Effective Induction of Receptor Degradation
J Pharmacol Exp Ther 2007 323: 534-546. Published online August 15, 2007; 10.1124/jpet.107.123422 [Abstract] [Full Text] [PDF]  

Kevin K. Ogden, John R. Falck, and Stephanie W. Watts

The Cytochrome P450 Inhibitor Ketoconazole Potentiates 5-Hydroxytryptamine-Induced Contraction in Rat Aorta
J Pharmacol Exp Ther 2007 323: 606-613. Published online August 8, 2007; 10.1124/jpet.107.128454 [Abstract] [Full Text] [PDF]  

Polly A. Hofmann, Mervyn Israel, Yoshihiro Koseki, Jeffrey Laskin, Joshua Gray, Aleksandra Janik, Trevor W. Sweatman, and Leonard Lothstein

N-Benzyladriamycin-14-valerate (AD 198): A Non-Cardiotoxic Anthracycline That Is Cardioprotective through PKC- Activation
J Pharmacol Exp Ther 2007 323: 658-664. Published online August 10, 2007; 10.1124/jpet.107.126110 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Murat Oz, Keun-Hang Yang, Meral Dinc, and Toni S. Shippenberg

The Endogenous Cannabinoid Anandamide Inhibits Cromakalim-Activated K⁺ Currents in Follicle-Enclosed Xenopus Oocytes
J Pharmacol Exp Ther 2007 323: 547-554. Published online August 6, 2007; 10.1124/jpet.107.125336 [Abstract] [Full Text] [PDF]  

Mitsi A. Blount, Roya Zoraghi, Emmanuel P. Bessay, Alfreda Beasley, Sharron H. Francis, and Jackie D. Corbin

Conversion of Phosphodiesterase-5 (PDE5) Catalytic Site to Higher Affinity by PDE5 Inhibitors
J Pharmacol Exp Ther 2007 323: 730-737. Published online August 9, 2007; 10.1124/jpet.107.126540 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Yi-Lin Chen, Po-Cheng Lin, Shee-Ping Chen, Chai-Ching Lin, Nu-Man Tsai, Yeung-Leung Cheng, Wen-Liang Chang, Shinn-Zong Lin, and Horng-Jyh Harn

Activation of Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1 via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase Revealed a Isochaihulactone-Triggered Apoptotic Pathway in Human Lung Cancer A549 Cells
J Pharmacol Exp Ther 2007 323: 746-756. Published online August 22, 2007; 10.1124/jpet.107.126193 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Bo Lin, Zhitao Li, Kaapjoo Park, Liu Deng, Ashok Pai, Ling Zhong, Michael C. Pirrung, and Nicholas J. G. Webster

Identification of Novel Orally Available Small Molecule Insulin Mimetics
J Pharmacol Exp Ther 2007 323: 579-585. Published online August 8, 2007; 10.1124/jpet.107.126102 [Abstract] [Full Text] [PDF] [Data Supplement]   

Astrid A. Ortiz, Lucinda F. Milardo, Lynn B. DeCarr, Thomas M. Buckholz, Michelle R. Mays, Thomas H. Claus, James N. Livingston, Cathy D. Mahle, and Kevin J. Lumb

A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents
J Pharmacol Exp Ther 2007 323: 692-700. Published online August 1, 2007; 10.1124/jpet.107.125211 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Edwin K. Jackson, Mingdi Zhang, Weili Liu, and Zaichuan Mi

Inhibition of Renal Dipeptidyl Peptidase IV Enhances Peptide YY_1–36-Induced Potentiation of Angiotensin II-Mediated Renal Vasoconstriction in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2007 323: 431-437. Published online August 28, 2007; 10.1124/jpet.107.126847 [Abstract] [Full Text] [PDF]  

Niels Hadrup, Jørgen S. Petersen, Søren Windfeld, Lotte Risom, Claus B. Andersen, Søren Nielsen, Sten Christensen, and Thomas E. N. Jonassen

Differential Down-Regulation of Aquaporin-2 in Rat Kidney Zones by Peripheral Nociceptin/Orphanin FQ Receptor Agonism and Vasopressin Type-2 Receptor Antagonism
J Pharmacol Exp Ther 2007 323: 516-524. Published online August 10, 2007; 10.1124/jpet.107.123588 [Abstract] [Full Text] [PDF]  

Ryan M. Pelis, Randall C. Hartman, Stephen H. Wright, Theresa M. Wunz, and Carlotta E. Groves

Influence of Estrogen and Xenoestrogens on Basolateral Uptake of Tetraethylammonium by Opossum Kidney Cells in Culture
J Pharmacol Exp Ther 2007 323: 555-561. Published online August 7, 2007; 10.1124/jpet.107.126748 [Abstract] [Full Text] [PDF] [Data Supplement]   

Magda F. Morton, Terrance D. Barrett, Wen Yan, Jamie M. Freedman, Guy Lagaud, Clodagh E. Prendergast, Veronica Moreno, Jayashree Pyati, Katherine Figueroa, Lina Li, Xiaodong Wu, Michele Rizzolio, James G. Breitenbucher, Kelly McClure, and Nigel P. Shankley

3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a Novel, Potent, and Selective Cholecystokinin 1 Receptor Antagonist: In Vitro and in Vivo Pharmacological Comparison with Dexloxiglumide
J Pharmacol Exp Ther 2007 323: 562-569. Published online August 7, 2007; 10.1124/jpet.107.124578 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Carolyn A. Foster, Laurence M. Howard, Alain Schweitzer, Elke Persohn, Peter C. Hiestand, Balázs Balatoni, Roland Reuschel, Christian Beerli, Manuela Schwartz, and Andreas Billich

Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis
J Pharmacol Exp Ther 2007 323: 469-475. Published online August 6, 2007; 10.1124/jpet.107.127183 [Abstract] [Full Text] [PDF]  

Anindya Bhattacharya, Brian P. Scott, Nadia Nasser, Hong Ao, Michael P. Maher, Adrienne E. Dubin, Devin M. Swanson, Nigel P. Shankley, Alan D. Wickenden, and Sandra R. Chaplan

Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs
J Pharmacol Exp Ther 2007 323: 665-674. Published online August 9, 2007; 10.1124/jpet.107.127258 [Abstract] [Full Text] [PDF]  

John P. Buchweitz, Peer W. F. Karmaus, Jack R. Harkema, Kurt J. Williams, and Norbert E. Kaminski

Modulation of Airway Responses to Influenza A/PR/8/34 by ⁹-Tetrahydrocannabinol in C57BL/6 Mice
J Pharmacol Exp Ther 2007 323: 675-683. Published online August 28, 2007; 10.1124/jpet.107.124719 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Paraskevi Gaganis, John O. Miners, James S. Brennan, Anthony Thomas, and Kathleen M. Knights

Human Renal Cortical and Medullary UDP-Glucuronosyltransferases (UGTs): Immunohistochemical Localization of UGT2B7 and UGT1A Enzymes and Kinetic Characterization of S-Naproxen Glucuronidation
J Pharmacol Exp Ther 2007 323: 422-430. Published online August 14, 2007; 10.1124/jpet.107.128603 [Abstract] [Full Text] [PDF]  

Xiuling Zhang, Jaime D'Agostino, Hong Wu, Qing-Yu Zhang, Linda von Weymarn, Sharon E. Murphy, and Xinxin Ding

CYP2A13: Variable Expression and Role in Human Lung Microsomal Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
J Pharmacol Exp Ther 2007 323: 570-578. Published online August 1, 2007; 10.1124/jpet.107.127068 [Abstract] [Full Text] [PDF]  

Hai-Lin Fang, Stephen C. Strom, Ewa Ellis, Zhengbo Duanmu, Jiaqi Fu, Zofia Duniec-Dmuchowski, Charles N. Falany, Josie L. Falany, Thomas A. Kocarek, and Melissa Runge-Morris

Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4 and Pregnane X Receptor
J Pharmacol Exp Ther 2007 323: 586-598. Published online August 8, 2007; 10.1124/jpet.107.124610 [Abstract] [Full Text] [PDF] [Data Supplement]   

NEUROPHARMACOLOGY:

Inna Vulih-Shultzman, Albert Pinhasov, Shmuel Mandel, Nikolaos Grigoriadis, Olga Touloumi, Zipora Pittel, and Illana Gozes

Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model
J Pharmacol Exp Ther 2007 323: 438-449. Published online August 24, 2007; 10.1124/jpet.107.129551 [Abstract] [Full Text] [PDF]  

Maciej Gasior, Natalie A. White, and Michael A. Rogawski

Prolonged Attenuation of Amygdala-Kindled Seizure Measures in Rats by Convection-Enhanced Delivery of the N-Type Calcium Channel Antagonists -Conotoxin GVIA and -Conotoxin MVIIA
J Pharmacol Exp Ther 2007 323: 458-468. Published online August 23, 2007; 10.1124/jpet.107.125047 [Abstract] [Full Text] [PDF]  

Daniel E. Rusyniak, Maria V. Zaretskaia, Dmitry V. Zaretsky, and Joseph A. DiMicco

3,4-Methylenedioxymethamphetamine- and 8-Hydroxy-2-di-n-propylamino-tetralin-Induced Hypothermia: Role and Location of 5-Hydroxytryptamine 1A Receptors
J Pharmacol Exp Ther 2007 323: 477-487. Published online August 16, 2007; 10.1124/jpet.107.126169 [Abstract] [Full Text] [PDF]  

Eduardo Candelario-Jalil, Saeid Taheri, Yi Yang, Rohit Sood, Mark Grossetete, Eduardo Y. Estrada, Bernd L. Fiebich, and Gary A. Rosenberg

Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor- in the Rat
J Pharmacol Exp Ther 2007 323: 488-498. Published online August 17, 2007; 10.1124/jpet.107.127035 [Abstract] [Full Text] [PDF]  

Fan Zhang, Shuangsong Hong, Vicki Stone, and Paula J. W. Smith

Expression of Cannabinoid CB₁ Receptors in Models of Diabetic Neuropathy
J Pharmacol Exp Ther 2007 323: 508-515. Published online August 16, 2007; 10.1124/jpet.107.128272 [Abstract] [Full Text] [PDF]  

Kenneth M. Wannemacher, Prem N. Yadav, and Richard D. Howells

A Select Set of Opioid Ligands Induce Up-Regulation by Promoting the Maturation and Stability of the Rat -Opioid Receptor in Human Embryonic Kidney 293 Cells
J Pharmacol Exp Ther 2007 323: 614-625. Published online August 24, 2007; 10.1124/jpet.107.125500 [Abstract] [Full Text] [PDF]  

Rochelle P. Coelho, Shawn G. Payne, Robert Bittman, Sarah Spiegel, and Carmen Sato-Bigbee

The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors
J Pharmacol Exp Ther 2007 323: 626-635. Published online August 28, 2007; 10.1124/jpet.107.123927 [Abstract] [Full Text] [PDF]  

Marek Schwendt and Jacqueline F. McGinty

Regulator of G-Protein Signaling 4 Interacts with Metabotropic Glutamate Receptor Subtype 5 in Rat Striatum: Relevance to Amphetamine Behavioral Sensitization
J Pharmacol Exp Ther 2007 323: 650-657. Published online August 10, 2007; 10.1124/jpet.107.128561 [Abstract] [Full Text] [PDF]  

Paolo Botta, Manuel Mameli, Kirsten L. Floyd, Richard A. Radcliffe, and C. Fernando Valenzuela

Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the ₆ GABA_A Receptor Subunit
J Pharmacol Exp Ther 2007 323: 684-691. Published online August 17, 2007; 10.1124/jpet.107.127894 [Abstract] [Full Text] [PDF]  

Sunil Sirohi, Priyank Kumar, and Byron C. Yoburn

µ-Opioid Receptor Up-Regulation and Functional Supersensitivity Are Independent of Antagonist Efficacy
J Pharmacol Exp Ther 2007 323: 701-707. Published online August 14, 2007; 10.1124/jpet.107.127019 [Abstract] [Full Text] [PDF]  

Takuma Mihara, Kayoko Mihara, Junko Yarimizu, Yasuyuki Mitani, Ritsuko Matsuda, Hiroko Yamamoto, Satoshi Aoki, Atsushi Akahane, Akinori Iwashita, and Nobuya Matsuoka

Pharmacological Characterization of a Novel, Potent Adenosine A₁ and A_2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in Models of Parkinson's Disease and Cognition
J Pharmacol Exp Ther 2007 323: 708-719. Published online August 7, 2007; 10.1124/jpet.107.121962 [Abstract] [Full Text] [PDF]  

John N. Mason, Darlene C. Deecher, Rhonda L. Richmond, Gary Stack, Paige E. Mahaney, Eugene Trybulski, Richard C. Winneker, and Randy D. Blakely

Desvenlafaxine Succinate Identifies Novel Antagonist Binding Determinants in the Human Norepinephrine Transporter
J Pharmacol Exp Ther 2007 323: 720-729. Published online August 2, 2007; 10.1124/jpet.107.125716 [Abstract] [Full Text] [PDF]  

Trent J. Volz, Sarah J. Farnsworth, Jill L. King, Evan L. Riddle, Glen R. Hanson, and Annette E. Fleckenstein

Methylphenidate Administration Alters Vesicular Monoamine Transporter-2 Function in Cytoplasmic and Membrane-Associated Vesicles
J Pharmacol Exp Ther 2007 323: 738-745. Published online August 10, 2007; 10.1124/jpet.107.126888 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Masahiko Watabe and Toshio Nakaki

Mitochondrial Complex I Inhibitor Rotenone-Elicited Dopamine Redistribution from Vesicles to Cytosol in Human Dopaminergic SH-SY5Y Cells
J Pharmacol Exp Ther 2007 323: 499-507. Published online August 28, 2007; 10.1124/jpet.107.127597 [Abstract] [Full Text] [PDF]  

Gonçalo C. Pereira, Ana F. Branco, Júlio A. C. Matos, Sandro L. Pereira, Donna Parke, Edward L. Perkins, Teresa L. Serafim, Vilma A. Sardão, Maria S. Santos, Antonio J. M. Moreno, Jon Holy, and Paulo J. Oliveira

Mitochondrially Targeted Effects of Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 Mouse Melanoma Cells: Comparison with Direct Effects on Isolated Mitochondrial Fractions
J Pharmacol Exp Ther 2007 323: 636-649. Published online August 17, 2007; 10.1124/jpet.107.128017 [Abstract] [Full Text] [PDF]  

ERRATUM:

Correction to "Lysophosphatidic Acid Decreases Epidermal Growth Factor Receptor Binding in Airway Epithelial Cells"
J Pharmacol Exp Ther 2007 323: 757. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.