BEHAVIORAL PHARMACOLOGY:

Bichoy H. Gabra, Fay K. Kessler, Joseph K. Ritter, William L. Dewey, and Forrest L. Smith

Decrease in N-Methyl-D-aspartic Acid Receptor-NR2B Subunit Levels by Intrathecal Short-Hairpin RNA Blocks Group I Metabotropic Glutamate Receptor-Mediated Hyperalgesia
J Pharmacol Exp Ther 2007 322: 186-194. Published online April 3, 2007; 10.1124/jpet.107.120071 [Abstract] [Full Text] [PDF]  

Kenneth D. Wild, Di Bian, Dawn Zhu, James Davis, Anthony W. Bannon, Tie J. Zhang, and Jean-Claude Louis

Antibodies to Nerve Growth Factor Reverse Established Tactile Allodynia in Rodent Models of Neuropathic Pain without Tolerance
J Pharmacol Exp Ther 2007 322: 282-287. Published online April 12, 2007; 10.1124/jpet.106.116236 [Abstract] [Full Text] [PDF]  

Francis Colpaert, Wouter Koek, Mark Kleven, and Joel Besnard

Induction by Antipsychotics of "Win-Shift" in the Drug Discrimination Paradigm
J Pharmacol Exp Ther 2007 322: 288-298. Published online April 12, 2007; 10.1124/jpet.107.119446 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

DaLiao Xiao, Xiaohui Huang, Shumei Yang, and Lubo Zhang

Direct Effects of Nicotine on Contractility of the Uterine Artery in Pregnancy
J Pharmacol Exp Ther 2007 322: 180-185. Published online April 2, 2007; 10.1124/jpet.107.119354 [Abstract] [Full Text] [PDF]  

K. Brixius, R. Lu, B. Boelck, S. Grafweg, F. Hoyer, C. Pott, U. Mehlhorn, W. Bloch, and R. H. G. Schwinger

Chronic Treatment with Carvedilol Improves Ca²⁺-Dependent ATP Consumption in Triton X-Skinned Fiber Preparations of Human Myocardium
J Pharmacol Exp Ther 2007 322: 222-227. Published online April 4, 2007; 10.1124/jpet.106.116798 [Abstract] [Full Text] [PDF]  

Ulrich Schaefer, Sandra Vorlova, Takuji Machida, Jerry P. Melchor, Sidney Strickland, and Roberto Levi

Modulation of Sympathetic Activity by Tissue Plasminogen Activator Is Independent of Plasminogen and Urokinase
J Pharmacol Exp Ther 2007 322: 265-273. Published online April 11, 2007; 10.1124/jpet.107.121335 [Abstract] [Full Text] [PDF]  

Bita Moazed and Linda M. Hiebert

An in Vitro Study with an Ussing Chamber Showing That Unfractionated Heparin Crosses Rat Gastric Mucosa
J Pharmacol Exp Ther 2007 322: 299-305. Published online April 13, 2007; 10.1124/jpet.106.116939 [Abstract] [Full Text] [PDF]  

Laurent Monassier, Boris Manoury, Chloé Bellocq, Jacques Weissenburger, Hugues Greney, Diane Zimmermann, Jean-Daniel Ehrhardt, Patrice Jaillon, Isabelle Baró, and Pascal Bousquet

₂-Receptor Ligand-Mediated Inhibition of Inwardly Rectifying K⁺ Channels in the Heart
J Pharmacol Exp Ther 2007 322: 341-350. Published online April 25, 2007; 10.1124/jpet.107.122044 [Abstract] [Full Text] [PDF]  

William A. Schumacher, Jeffrey S. Bostwick, Martin L. Ogletree, Anne B. Stewart, Thomas E. Steinbacher, Ji Hua, Laura A. Price, Pancras C. Wong, and Robert P. Rehfuss

Biomarker Optimization to Track the Antithrombotic and Hemostatic Effects of Clopidogrel in Rats
J Pharmacol Exp Ther 2007 322: 369-377. Published online April 9, 2007; 10.1124/jpet.106.119156 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Yuichiro Inoue, Lina Yao, F. Woodward Hopf, Peidong Fan, Zhan Jiang, Antonello Bonci, and Ivan Diamond

Nicotine and Ethanol Activate Protein Kinase A Synergistically via G_i Subunits in Nucleus Accumbens/Ventral Tegmental Cocultures: The Role of Dopamine D₁/D₂ and Adenosine A_2A Receptors
J Pharmacol Exp Ther 2007 322: 23-29. Published online April 27, 2007; 10.1124/jpet.107.120675 [Abstract] [Full Text] [PDF]  

Bo Lin, Michael C. Pirrung, Liu Deng, Zhitao Li, Yufa Liu, and Nicholas J. G. Webster

Neuroprotection by Small Molecule Activators of the Nerve Growth Factor Receptor
J Pharmacol Exp Ther 2007 322: 59-69. Published online April 27, 2007; 10.1124/jpet.106.118034 [Abstract] [Full Text] [PDF] [Data Supplement]   

Shannon S. A. Coates, Bruce E. Lehnert, Sunil Sharma, Susan M. Kindell, and Ronald K. Gary

Beryllium Induces Premature Senescence in Human Fibroblasts
J Pharmacol Exp Ther 2007 322: 70-79. Published online March 29, 2007; 10.1124/jpet.106.118018 [Abstract] [Full Text] [PDF]  

Rasmus Jorgensen, Valentina Kubale, Milka Vrecl, Thue W. Schwartz, and Christian E. Elling

Oxyntomodulin Differentially Affects Glucagon-Like Peptide-1 Receptor -Arrestin Recruitment and Signaling through G
J Pharmacol Exp Ther 2007 322: 148-154. Published online March 29, 2007; 10.1124/jpet.107.120006 [Abstract] [Full Text] [PDF] [Data Supplement]   

R. A. Bakker, M. W. Nicholas, T. T. Smith, E. S. Burstein, U. Hacksell, H. Timmerman, R. Leurs, M. R. Brann, and D. M. Weiner

In Vitro Pharmacology of Clinically Used Central Nervous System-Active Drugs as Inverse H₁ Receptor Agonists
J Pharmacol Exp Ther 2007 322: 172-179. Published online April 2, 2007; 10.1124/jpet.106.118869 [Abstract] [Full Text] [PDF]  

Anke J. Roelofs, Claire M. Edwards, R. Graham G. Russell, F. Hal Ebetino, Michael J. Rogers, and Philippa A. Hulley

Apomine Enhances the Antitumor Effects of Lovastatin on Myeloma Cells by Down-Regulating 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase
J Pharmacol Exp Ther 2007 322: 228-235. Published online April 5, 2007; 10.1124/jpet.106.116467 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Dan Lu, M. Guillaume Wientjes, Ze Lu, and Jessie L.-S. Au

Tumor Priming Enhances Delivery and Efficacy of Nanomedicines
J Pharmacol Exp Ther 2007 322: 80-88. Published online April 9, 2007; 10.1124/jpet.107.121632 [Abstract] [Full Text] [PDF]  

Aleksandra A. Pandyra, Randal Berg, Mark Vincent, and James Koropatnick

Combination Silencer RNA (siRNA) Targeting Bcl-2 Antagonizes siRNA against Thymidylate Synthase in Human Tumor Cell Lines
J Pharmacol Exp Ther 2007 322: 123-132. Published online April 23, 2007; 10.1124/jpet.106.115394 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Makoto Shigeto, Masashi Katsura, Masafumi Matsuda, Seitaro Ohkuma, and Kohei Kaku

Nateglinide and Mitiglinide, but Not Sulfonylureas, Induce Insulin Secretion through a Mechanism Mediated by Calcium Release from Endoplasmic Reticulum
J Pharmacol Exp Ther 2007 322: 1-7. Published online April 4, 2007; 10.1124/jpet.107.120592 [Abstract] [Full Text] [PDF]  

Gary J. Grover, Celeste Dunn, Ngoc-Ha Nguyen, Jamie Boulet, Gao Dong, Jason Domogauer, Peter Barbounis, and Thomas S. Scanlan

Pharmacological Profile of the Thyroid Hormone Receptor Antagonist NH3 in Rats
J Pharmacol Exp Ther 2007 322: 385-390. Published online April 17, 2007; 10.1124/jpet.106.116152 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Sarah Faubel, Eli C. Lewis, Leonid Reznikov, Danica Ljubanovic, Thomas S. Hoke, Hilary Somerset, Dong-Jin Oh, Lawrence Lu, Christina L. Klein, Charles A. Dinarello, and Charles L. Edelstein

Cisplatin-Induced Acute Renal Failure Is Associated with an Increase in the Cytokines Interleukin (IL)-1, IL-18, IL-6, and Neutrophil Infiltration in the Kidney
J Pharmacol Exp Ther 2007 322: 8-15. Published online March 30, 2007; 10.1124/jpet.107.119792 [Abstract] [Full Text] [PDF]  

Robert D. Finn, Aileen W. McLaren, Dianne Carrie, Colin J. Henderson, and C. Roland Wolf

Conditional Deletion of Cytochrome P450 Oxidoreductase in the Liver and Gastrointestinal Tract: A New Model for Studying the Functions of the P450 System
J Pharmacol Exp Ther 2007 322: 40-47. Published online April 13, 2007; 10.1124/jpet.107.121780 [Abstract] [Full Text] [PDF]  

Maurits M. Barendrecht, Arthur C. M. Mulders, Henk van der Poel, Maurice J. B. van den Hoff, Martina Schmidt, and Martin C. Michel

Role of Transforming Growth Factor in Rat Bladder Smooth Muscle Cell Proliferation
J Pharmacol Exp Ther 2007 322: 117-122. Published online April 13, 2007; 10.1124/jpet.106.119115 [Abstract] [Full Text] [PDF]  

Melissa A. Burmeister and Daniel R. Kapusta

Centrally Administered Nociceptin/Orphanin FQ (N/OFQ) Evokes Bradycardia, Hypotension, and Diuresis in Mice via Activation of Central N/OFQ Peptide Receptors
J Pharmacol Exp Ther 2007 322: 324-331. Published online April 23, 2007; 10.1124/jpet.107.120394 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

M. C. Zerrate, M. Pletnikov, S. L. Connors, D. L. Vargas, F. J. Seidler, A. W. Zimmerman, T. A. Slotkin, and C. A. Pardo

Neuroinflammation and Behavioral Abnormalities after Neonatal Terbutaline Treatment in Rats: Implications for Autism
J Pharmacol Exp Ther 2007 322: 16-22. Published online March 30, 2007; 10.1124/jpet.107.121483 [Abstract] [Full Text] [PDF]  

Alison S. Williams, Razao Issa, Sum Yee Leung, Puneeta Nath, Gregory D. Ferguson, Brydon L. Bennett, Ian M. Adcock, and Kian Fan Chung

Attenuation of Ozone-Induced Airway Inflammation and Hyper-Responsiveness by c-Jun NH₂ Terminal Kinase Inhibitor SP600125
J Pharmacol Exp Ther 2007 322: 351-359. Published online April 25, 2007; 10.1124/jpet.107.121624 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Scott G. Summerfield, Kevin Read, David J. Begley, Tanja Obradovic, Ismael J. Hidalgo, Sara Coggon, Ann V. Lewis, Rod A. Porter, and Phil Jeffrey

Central Nervous System Drug Disposition: The Relationship between in Situ Brain Permeability and Brain Free Fraction
J Pharmacol Exp Ther 2007 322: 205-213. Published online April 3, 2007; 10.1124/jpet.107.121525 [Abstract] [Full Text] [PDF] [Data Supplement]   

Michael S. Madejczyk, David A. Aremu, Tracey A. Simmons-Willis, Thomas W. Clarkson, and Nazzareno Ballatori

Accelerated Urinary Excretion of Methylmercury following Administration of Its Antidote N-Acetylcysteine Requires Mrp2/Abcc2, the Apical Multidrug Resistance-Associated Protein
J Pharmacol Exp Ther 2007 322: 378-384. Published online April 11, 2007; 10.1124/jpet.107.122812 [Abstract] [Full Text] [PDF]  

Xiaochao Ma, Yatrik M. Shah, Grace L. Guo, Ting Wang, Kristopher W. Krausz, Jeffrey R. Idle, and Frank J. Gonzalez

Rifaximin Is a Gut-Specific Human Pregnane X Receptor Activator
J Pharmacol Exp Ther 2007 322: 391-398. Published online April 18, 2007; 10.1124/jpet.107.121913 [Abstract] [Full Text] [PDF]  

Pierantonio Menna, Emanuela Salvatorelli, and Giorgio Minotti

Doxorubicin Degradation in Cardiomyocytes
J Pharmacol Exp Ther 2007 322: 408-419. Published online April 27, 2007; 10.1124/jpet.107.122820 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Eric C. Peterson, Melinda Gunnell, Yingni Che, Robyn L. Goforth, F. Ivy Carroll, Ralph Henry, Huimin Liu, and S. Michael Owens

Using Hapten Design to Discover Therapeutic Monoclonal Antibodies for Treating Methamphetamine Abuse
J Pharmacol Exp Ther 2007 322: 30-39. Published online April 23, 2007; 10.1124/jpet.106.117150 [Abstract] [Full Text] [PDF]  

Cristiane Lopes, Edna F. R. Pereira, Hui-Qiu Wu, Puranik Purushottamachar, Vincent Njar, Robert Schwarcz, and Edson X. Albuquerque

Competitive Antagonism between the Nicotinic Allosteric Potentiating Ligand Galantamine and Kynurenic Acid at 7* Nicotinic Receptors
J Pharmacol Exp Ther 2007 322: 48-58. Published online April 19, 2007; 10.1124/jpet.107.123109 [Abstract] [Full Text] [PDF]  

Esther Berrocoso and Juan Antonio Mico

In Vivo Effect of Venlafaxine on Locus Coeruleus Neurons: Role of Opioid, ₂-Adrenergic, and 5-Hydroxytryptamine_1A Receptors
J Pharmacol Exp Ther 2007 322: 101-107. Published online April 12, 2007; 10.1124/jpet.107.120915 [Abstract] [Full Text] [PDF]  

Rakesh K. Singh, Ju Shi, Bozena W. Zemaitaitis, and Nancy A. Muma

Olanzapine Increases RGS7 Protein Expression via Stimulation of the Janus Tyrosine Kinase-Signal Transducer and Activator of Transcription Signaling Cascade
J Pharmacol Exp Ther 2007 322: 133-140. Published online March 28, 2007; 10.1124/jpet.107.120386 [Abstract] [Full Text] [PDF]  

E. A. van Vliet, R. van Schaik, P. M. Edelbroek, R. A. Voskuyl, S. Redeker, E. Aronica, W. J. Wadman, and J. A. Gorter

Region-Specific Overexpression of P-glycoprotein at the Blood-Brain Barrier Affects Brain Uptake of Phenytoin in Epileptic Rats
J Pharmacol Exp Ther 2007 322: 141-147. Published online March 28, 2007; 10.1124/jpet.107.121178 [Abstract] [Full Text] [PDF]  

Mary M. Lunzer and Philip S. Portoghese

Selectivity of - and -Opioid Ligands Depends on the Route of Central Administration in Mice
J Pharmacol Exp Ther 2007 322: 166-171. Published online March 30, 2007; 10.1124/jpet.107.120279 [Abstract] [Full Text] [PDF]  

Zheng-Ge Zhao, Man Zhang, Xi-Min Zeng, Xiao-Wei Fei, Lin-Yun Liu, Zhi-Hong Zhang, and Yan-Ai Mei

Flufenamic Acid Bi-Directionally Modulates the Transient Outward K⁺ Current in Rat Cerebellar Granule Cells
J Pharmacol Exp Ther 2007 322: 195-204. Published online April 3, 2007; 10.1124/jpet.106.117556 [Abstract] [Full Text] [PDF]  

Guoyi Ma, Supriya A. Bavadekar, Yolande M. Davis, Shilpa G. Lalchandani, Rangaswamy Nagmani, Brian T. Schaneberg, Ikhlas A. Khan, and Dennis R. Feller

Pharmacological Effects of Ephedrine Alkaloids on Human ₁- and ₂-Adrenergic Receptor Subtypes
J Pharmacol Exp Ther 2007 322: 214-221. Published online April 3, 2007; 10.1124/jpet.107.120709 [Abstract] [Full Text] [PDF]  

Roberto Russo, Jesse LoVerme, Giovanna La Rana, Timothy R. Compton, Jeff Parrott, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Antonio Calignano, and Daniele Piomelli

The Fatty Acid Amide Hydrolase Inhibitor URB597 (Cyclohexylcarbamic Acid 3'-Carbamoylbiphenyl-3-yl Ester) Reduces Neuropathic Pain after Oral Administration in Mice
J Pharmacol Exp Ther 2007 322: 236-242. Published online April 5, 2007; 10.1124/jpet.107.119941 [Abstract] [Full Text] [PDF]  

Aaron D. Smith and M. Saeed Dar

Behavioral Cross-Tolerance between Repeated Intracerebellar Nicotine and Acute ⁹-Tetrahydrocannabinol-Induced Cerebellar Ataxia: Role of Cerebellar Nitric Oxide
J Pharmacol Exp Ther 2007 322: 243-253. Published online April 6, 2007; 10.1124/jpet.107.120634 [Abstract] [Full Text] [PDF]  

Kamondanai Hemstapat, Herve Da Costa, Yi Nong, Ashley E. Brady, Qingwei Luo, Colleen M. Niswender, Gilles D. Tamagnan, and P. Jeffrey Conn

A Novel Family of Potent Negative Allosteric Modulators of Group II Metabotropic Glutamate Receptors
J Pharmacol Exp Ther 2007 322: 254-264. Published online April 6, 2007; 10.1124/jpet.106.117093 [Abstract] [Full Text] [PDF]  

Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Akemichi Baba, and Toshio Matsuda

Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one), a Radical Scavenger, Prevents 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Neurotoxicity in the Substantia Nigra but Not the Striatum
J Pharmacol Exp Ther 2007 322: 274-281. Published online April 11, 2007; 10.1124/jpet.106.119206 [Abstract] [Full Text] [PDF]  

David C. Perry, Danyan Mao, Allison B. Gold, J. Michael McIntosh, John C. Pezzullo, and Kenneth J. Kellar

Chronic Nicotine Differentially Regulates 6- and 3-Containing Nicotinic Cholinergic Receptors in Rat Brain
J Pharmacol Exp Ther 2007 322: 306-315. Published online April 19, 2007; 10.1124/jpet.107.121228 [Abstract] [Full Text] [PDF]  

E. Machová, J. Jakubík, E. E. El-Fakahany, and V. Dolezal

Wash-Resistantly Bound Xanomeline Inhibits Acetylcholine Release by Persistent Activation of Presynaptic M₂ and M₄ Muscarinic Receptors in Rat Brain
J Pharmacol Exp Ther 2007 322: 316-323. Published online April 19, 2007; 10.1124/jpet.107.122093 [Abstract] [Full Text] [PDF]  

Chong-Bin Zhu, Jennifer A. Steiner, Jaclyn L. Munn, Lynette C. Daws, William A. Hewlett, and Randy D. Blakely

Rapid Stimulation of Presynaptic Serotonin Transport by A₃ Adenosine Receptors
J Pharmacol Exp Ther 2007 322: 332-340. Published online April 25, 2007; 10.1124/jpet.107.121665 [Abstract] [Full Text] [PDF]  

Víctor Fernández-Dueñas, Olga Pol, Paula García-Nogales, Laura Hernández, Eulàlia Planas, and Margarita M. Puig

Tolerance to the Antinociceptive and Antiexudative Effects of Morphine in a Murine Model of Peripheral Inflammation
J Pharmacol Exp Ther 2007 322: 360-368. Published online April 27, 2007; 10.1124/jpet.106.118901 [Abstract] [Full Text] [PDF]  

D. Kota, B. R. Martin, S. E. Robinson, and M. I. Damaj

Nicotine Dependence and Reward Differ between Adolescent and Adult Male Mice
J Pharmacol Exp Ther 2007 322: 399-407. Published online April 19, 2007; 10.1124/jpet.107.121616 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Marjo de Graauw, Sylvia Le Dévédec, Ine Tijdens, Mirjam B. Smeets, André M. Deelder, and Bob van de Water

Proteomic Analysis of Alternative Protein Tyrosine Phosphorylation in 1,2-Dichlorovinyl-Cysteine-Induced Cytotoxicity in Primary Cultured Rat Renal Proximal Tubular Cells
J Pharmacol Exp Ther 2007 322: 89-100. Published online April 18, 2007; 10.1124/jpet.106.117689 [Abstract] [Full Text] [PDF] [Data Supplements]   

Swaran J. S. Flora, Geetu Saxena, and Ashish Mehta

Reversal of Lead-Induced Neuronal Apoptosis by Chelation Treatment in Rats: Role of Reactive Oxygen Species and Intracellular Ca²⁺
J Pharmacol Exp Ther 2007 322: 108-116. Published online April 12, 2007; 10.1124/jpet.107.121996 [Abstract] [Full Text] [PDF]  

Zhi-guo Sheng, Shuangqing Peng, Chang-yong Wang, Hong-bo Li, Ravindra K. Hajela, Yim-ei Wang, Qian-qian Li, Mi-feng Liu, Yan-sheng Dong, and Gang Han

Apoptosis in Microencapsulated Juvenile Rabbit Chondrocytes Induced by Ofloxacin: Role Played by ₁-Integrin Receptor
J Pharmacol Exp Ther 2007 322: 155-165. Published online March 30, 2007; 10.1124/jpet.106.118224 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Matthias Karst

Comments on "Cannabimimetic Properties of Ajulemic Acid"
J Pharmacol Exp Ther 2007 322: 420-421. [Full Text] [PDF]  

Stephen Fowler, Siân M. Lennon, Gerhard Hoffmann, and Craig R. Rayner

Comments on "Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel"
J Pharmacol Exp Ther 2007 322: 422-423. [Full Text] [PDF]  

Deshi Shi, Jian Yang, Dongfang Yang, Edward L. LeCluyse, Chris Black, Li You, Fatemeh Akhlaghi, and Bingfang Yan

Response to Comments on "Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel"
J Pharmacol Exp Ther 2007 322: 424-425. [Full Text] [PDF]  

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