PERSPECTIVES IN PHARMACOLOGY:

Kazuhiro Ito, Gaetano Caramori, and Ian M. Adcock

Therapeutic Potential of Phosphatidylinositol 3-Kinase Inhibitors in Inflammatory Respiratory Disease
J Pharmacol Exp Ther 2007 321: 1-8. Published online October 4, 2006; 10.1124/jpet.106.111674 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Jun Nagai, Mamoru Kurokawa, Hiroshi Takeshima, Brigitte L. Kieffer, and Hiroshi Ueda

Circadian-Dependent Learning and Memory Enhancement in Nociceptin Receptor-Deficient Mice with a Novel KUROBOX Apparatus Using Stress-Free Positive Cue Task
J Pharmacol Exp Ther 2007 321: 195-201. Published online January 5, 2007; 10.1124/jpet.106.115121 [Abstract] [Full Text] [PDF] [Data Supplement]   

Jun-Xu Li, Ginger L. Becker, John R. Traynor, Ze-Hui Gong, and Charles P. France

Thienorphine: Receptor Binding and Behavioral Effects in Rhesus Monkeys
J Pharmacol Exp Ther 2007 321: 227-236. Published online January 12, 2007; 10.1124/jpet.106.113290 [Abstract] [Full Text] [PDF]  

Gianluigi Tanda, Aaron L. Ebbs, Theresa A. Kopajtic, Lyn M. Elias, Bettye L. Campbell, Amy H. Newman, and Jonathan L. Katz

Effects of Muscarinic M₁ Receptor Blockade on Cocaine-Induced Elevations of Brain Dopamine Levels and Locomotor Behavior in Rats
J Pharmacol Exp Ther 2007 321: 334-344. Published online January 25, 2007; 10.1124/jpet.106.118067 [Abstract] [Full Text] [PDF]  

Tadanobu Utsuki, Nao Uchimura, Mitsuru Irikura, Hiroshi Moriuchi, Harold W. Holloway, Qian-Sheng Yu, Edward L. Spangler, Jacek Mamczarz, Donald K. Ingram, Tetsumi Irie, and Nigel H. Greig

Preclinical Investigation of the Topical Administration of Phenserine: Transdermal Flux, Cholinesterase Inhibition, and Cognitive Efficacy
J Pharmacol Exp Ther 2007 321: 353-361. Published online January 25, 2007; 10.1124/jpet.106.118000 [Abstract] [Full Text] [PDF]  

Marcello Solinas, Gianluigi Tanda, Zuzana Justinova, Carrie E. Wertheim, Sevil Yasar, Daniele Piomelli, Subramanian K. Vadivel, Alexandros Makriyannis, and Steven R. Goldberg

The Endogenous Cannabinoid Anandamide Produces -9-Tetrahydrocannabinol-Like Discriminative and Neurochemical Effects That Are Enhanced by Inhibition of Fatty Acid Amide Hydrolase but Not by Inhibition of Anandamide Transport
J Pharmacol Exp Ther 2007 321: 370-380. Published online January 8, 2007; 10.1124/jpet.106.114124 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Kumkum Ganguly, Juan-Carlos Murciano, Randal Westrick, John Leferovich, Douglas B. Cines, and Vladimir R. Muzykantov

The Glycocalyx Protects Erythrocyte-Bound Tissue-Type Plasminogen Activator from Enzymatic Inhibition
J Pharmacol Exp Ther 2007 321: 158-164. Published online January 10, 2007; 10.1124/jpet.106.114405 [Abstract] [Full Text] [PDF]  

Volodymyr Labinskyy, Michelle Bellomo, Margaret P. Chandler, Martin E. Young, Vincenzo Lionetti, Khaled Qanud, Federico Bigazzi, Tiziana Sampietro, William C. Stanley, and Fabio A. Recchia

Chronic Activation of Peroxisome Proliferator-Activated Receptor- with Fenofibrate Prevents Alterations in Cardiac Metabolic Phenotype without Changing the Onset of Decompensation in Pacing-Induced Heart Failure
J Pharmacol Exp Ther 2007 321: 165-171. Published online January 10, 2007; 10.1124/jpet.106.116871 [Abstract] [Full Text] [PDF]  

Peipei Wang, Heather Fraser, Steven G. Lloyd, Jeffrey J. McVeigh, Luiz Belardinelli, and John C. Chatham

A Comparison between Ranolazine and CVT-4325, a Novel Inhibitor of Fatty Acid Oxidation, on Cardiac Metabolism and Left Ventricular Function in Rat Isolated Perfused Heart during Ischemia and Reperfusion
J Pharmacol Exp Ther 2007 321: 213-220. Published online January 3, 2007; 10.1124/jpet.106.115519 [Abstract] [Full Text] [PDF]  

S. M. Gardiner, J. E. March, P. A. Kemp, and T. Bennett

A Comparison between the Cardiovascular Actions of Urocortin 1 and Urocortin 2 (Stresscopin-Related Peptide) in Conscious Rats
J Pharmacol Exp Ther 2007 321: 221-226. Published online January 19, 2007; 10.1124/jpet.106.116962 [Abstract] [Full Text] [PDF]  

Yolanda Álvarez, José V. Pérez-Girón, Raquel Hernanz, Ana M. Briones, Ana García-Redondo, Amada Beltrán, María J. Alonso, and Mercedes Salaices

Losartan Reduces the Increased Participation of Cyclooxygenase-2-Derived Products in Vascular Responses of Hypertensive Rats
J Pharmacol Exp Ther 2007 321: 381-388. Published online January 23, 2007; 10.1124/jpet.106.115287 [Abstract] [Full Text] [PDF]  

Thomas Dschietzig, Christoph Richter, Louay Asswad, Gert Baumann, and Karl Stangl

Hypoxic Induction of Receptor Activity-Modifying Protein 2 Alters Regulation of Pulmonary Endothelin-1 by Adrenomedullin: Induction under Normoxia Versus Inhibition under Hypoxia
J Pharmacol Exp Ther 2007 321: 409-419. Published online January 24, 2007; 10.1124/jpet.106.114298 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Austin M. Guo, Ali S. Arbab, John R. Falck, Ping Chen, Paul A. Edwards, Richard J. Roman, and A. Guillermo Scicli

Activation of Vascular Endothelial Growth Factor through Reactive Oxygen Species Mediates 20-Hydroxyeicosatetraenoic Acid-Induced Endothelial Cell Proliferation
J Pharmacol Exp Ther 2007 321: 18-27. Published online January 8, 2007; 10.1124/jpet.106.115360 [Abstract] [Full Text] [PDF]  

Samina Salim, Kelly M. Standifer, and Douglas C. Eikenburg

Extracellular Signal-Regulated Kinase 1/2-Mediated Transcriptional Regulation of G-Protein-Coupled Receptor Kinase 3 Expression in Neuronal Cells
J Pharmacol Exp Ther 2007 321: 51-59. Published online January 25, 2007; 10.1124/jpet.106.116921 [Abstract] [Full Text] [PDF]  

Jane L. Rose, Kevin C. Reeves, Rostislav I. Likhotvorik, and Dale G. Hoyt

Base Excision Repair Proteins Are Required for Integrin-Mediated Suppression of Bleomycin-Induced DNA Breakage in Murine Lung Endothelial Cells
J Pharmacol Exp Ther 2007 321: 318-326. Published online January 3, 2007; 10.1124/jpet.106.113498 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Qingyu Zhou, Ping Guo, Xiaomin Wang, Silpa Nuthalapati, and James M. Gallo

Preclinical Pharmacokinetic and Pharmacodynamic Evaluation of Metronomic and Conventional Temozolomide Dosing Regimens
J Pharmacol Exp Ther 2007 321: 265-275. Published online January 26, 2007; 10.1124/jpet.106.118265 [Abstract] [Full Text] [PDF]  

Lisa M. Greene, Liam Kelly, Valeria Onnis, Giuseppe Campiani, Mark Lawler, D. Clive Williams, and Daniela M. Zisterer

STI-571 (Imatinib Mesylate) Enhances the Apoptotic Efficacy of Pyrrolo-1,5-Benzoxazepine-6, a Novel Microtubule-Targeting Agent, in Both STI-571-Sensitive and -Resistant Bcr-Abl-Positive Human Chronic Myeloid Leukemia Cells
J Pharmacol Exp Ther 2007 321: 288-297. Published online January 3, 2007; 10.1124/jpet.106.116640 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Effie Tozzo, Randolph Ponticiello, JoAnn Swartz, Dennis Farrelly, Rachel Zebo, Gustav Welzel, Donald Egan, Lori Kunselman, Andrew Peters, Liqun Gu, Michele French, Sean Chen, Pratik Devasthale, Evan Janovitz, Ada Staal, Thomas Harrity, Rene Belder, Peter T. Cheng, Jean Whaley, Simeon Taylor, and Narayanan Hariharan

The Dual Peroxisome Proliferator-Activated Receptor / Activator Muraglitazar Prevents the Natural Progression of Diabetes in db/db Mice
J Pharmacol Exp Ther 2007 321: 107-115. Published online January 26, 2007; 10.1124/jpet.106.115337 [Abstract] [Full Text] [PDF]  

Arvinder K. Dhalla, Melissa Santikul, Michelle Smith, Mei-Yee Wong, John C. Shryock, and Luiz Belardinelli

Antilipolytic Activity of a Novel Partial A₁ Adenosine Receptor Agonist Devoid of Cardiovascular Effects: Comparison with Nicotinic Acid
J Pharmacol Exp Ther 2007 321: 327-333. Published online January 4, 2007; 10.1124/jpet.106.114421 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Ragini Vittal, Hengmin Zhang, MeiLan K. Han, Bethany B. Moore, Jeffrey C. Horowitz, and Victor J. Thannickal

Effects of the Protein Kinase Inhibitor, Imatinib Mesylate, on Epithelial/Mesenchymal Phenotypes: Implications for Treatment of Fibrotic Diseases
J Pharmacol Exp Ther 2007 321: 35-44. Published online January 11, 2007; 10.1124/jpet.106.113407 [Abstract] [Full Text] [PDF]  

C. B. Forsyth, A. Banan, A. Farhadi, J. Z. Fields, Y. Tang, M. Shaikh, L. J. Zhang, P. A. Engen, and A. Keshavarzian

Regulation of Oxidant-Induced Intestinal Permeability by Metalloprotease-Dependent Epidermal Growth Factor Receptor Signaling
J Pharmacol Exp Ther 2007 321: 84-97. Published online January 12, 2007; 10.1124/jpet.106.113019 [Abstract] [Full Text] [PDF]  

Massimo Bolognesi, David Sacerdoti, Anna Piva, Marco Di Pascoli, Francesca Zampieri, Santina Quarta, Roberto Motterlini, Paolo Angeli, Carlo Merkel, and Angelo Gatta

Carbon Monoxide-Mediated Activation of Large-Conductance Calcium-Activated Potassium Channels Contributes to Mesenteric Vasodilatation in Cirrhotic Rats
J Pharmacol Exp Ther 2007 321: 187-194. Published online January 17, 2007; 10.1124/jpet.106.116665 [Abstract] [Full Text] [PDF]  

Yoshitane Nozaki, Hiroyuki Kusuhara, Tsunenori Kondo, Maki Hasegawa, Yoshiyuki Shiroyanagi, Hayakazu Nakazawa, Teruo Okano, and Yuichi Sugiyama

Characterization of the Uptake of Organic Anion Transporter (OAT) 1 and OAT3 Substrates by Human Kidney Slices
J Pharmacol Exp Ther 2007 321: 362-369. Published online January 25, 2007; 10.1124/jpet.106.113076 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Fumitaka Kamachi, Hyun Seung Ban, Noriyasu Hirasawa, and Kazuo Ohuchi

Inhibition of Lipopolysaccharide-Induced Prostaglandin E₂ Production and Inflammation by the Na⁺/H⁺ Exchanger Inhibitors
J Pharmacol Exp Ther 2007 321: 345-352. Published online January 19, 2007; 10.1124/jpet.106.116251 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Andrew Rowland, Paraskevi Gaganis, David J. Elliot, Peter I. Mackenzie, Kathleen M. Knights, and John O. Miners

Binding of Inhibitory Fatty Acids Is Responsible for the Enhancement of UDP-Glucuronosyltransferase 2B7 Activity by Albumin: Implications for in Vitro-in Vivo Extrapolation
J Pharmacol Exp Ther 2007 321: 137-147. Published online January 19, 2007; 10.1124/jpet.106.118216 [Abstract] [Full Text] [PDF]  

Seiji Miyauchi, Elangovan Gopal, Santosh V. Thakkar, Satoshi Ichikawa, Puttur D. Prasad, and Vadivel Ganapathy

Differential Modulation of Sodium- and Chloride-Dependent Opioid Peptide Transport System by Small Nonopioid Peptides and Free Amino Acids
J Pharmacol Exp Ther 2007 321: 257-264. Published online January 26, 2007; 10.1124/jpet.106.116806 [Abstract] [Full Text] [PDF]  

Hsia-lien Lin and Paul F. Hollenberg

The Inactivation of Cytochrome P450 3A5 by 17-Ethynylestradiol Is Cytochrome b₅-Dependent: Metabolic Activation of the Ethynyl Moiety Leads to the Formation of Glutathione Conjugates, a Heme Adduct, and Covalent Binding to the Apoprotein
J Pharmacol Exp Ther 2007 321: 276-287. Published online January 24, 2007; 10.1124/jpet.106.117861 [Abstract] [Full Text] [PDF]  

Rheem A. Totah, Kyle E. Allen, Pamela Sheffels, Dale Whittington, and Evan D. Kharasch

Enantiomeric Metabolic Interactions and Stereoselective Human Methadone Metabolism
J Pharmacol Exp Ther 2007 321: 389-399. Published online January 26, 2007; 10.1124/jpet.106.117580 [Abstract] [Full Text] [PDF]  

G. Elaut, G. Laus, E. Alexandre, L. Richert, P. Bachellier, D. Tourwé, V. Rogiers, and T. Vanhaecke

A Metabolic Screening Study of Trichostatin A (TSA) and TSA-Like Histone Deacetylase Inhibitors in Rat and Human Primary Hepatocyte Cultures
J Pharmacol Exp Ther 2007 321: 400-408. Published online January 11, 2007; 10.1124/jpet.106.116202 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Toshiyuki Mizushima, Koichi Obata, Hirokazu Katsura, Jun Sakurai, Kimiko Kobayashi, Hiroki Yamanaka, Yi Dai, Tetsuo Fukuoka, Takashi Mashimo, and Koichi Noguchi

Intensity-Dependent Activation of Extracellular Signal-Regulated Protein Kinase 5 in Sensory Neurons Contributes to Pain Hypersensitivity
J Pharmacol Exp Ther 2007 321: 28-34. Published online January 19, 2007; 10.1124/jpet.106.116749 [Abstract] [Full Text] [PDF]  

Sang Won Suh, Jennifer P. Bergher, Christopher M. Anderson, Judith L. Treadway, Keld Fosgerau, and Raymond A. Swanson

Astrocyte Glycogen Sustains Neuronal Activity during Hypoglycemia: Studies with the Glycogen Phosphorylase Inhibitor CP-316,819 ([R-R*,S*]-5-Chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide)
J Pharmacol Exp Ther 2007 321: 45-50. Published online January 24, 2007; 10.1124/jpet.106.115550 [Abstract] [Full Text] [PDF]  

Adam W. Hendricson, Regina E. Maldve, Armando G. Salinas, Jonathan W. Theile, Tao A. Zhang, Laurea M. Diaz, and Richard A. Morrisett

Aberrant Synaptic Activation of N-Methyl-D-aspartate Receptors Underlies Ethanol Withdrawal Hyperexcitability
J Pharmacol Exp Ther 2007 321: 60-72. Published online January 17, 2007; 10.1124/jpet.106.111419 [Abstract] [Full Text] [PDF]  

Chin-Wei Huang, Chao-Ching Huang, and Sheng-Nan Wu

Activation by Zonisamide, a Newer Antiepileptic Drug, of Large-Conductance Calcium-Activated Potassium Channel in Differentiated Hippocampal Neuron-Derived H19-7 Cells
J Pharmacol Exp Ther 2007 321: 98-106. Published online January 25, 2007; 10.1124/jpet.106.116954 [Abstract] [Full Text] [PDF]  

Zhihua Xie, Susan V. Westmoreland, Mary E. Bahn, Guo-Lin Chen, Hong Yang, Eric J. Vallender, Wei-Dong Yao, Bertha K. Madras, and Gregory M. Miller

Rhesus Monkey Trace Amine-Associated Receptor 1 Signaling: Enhancement by Monoamine Transporters and Attenuation by the D2 Autoreceptor in Vitro
J Pharmacol Exp Ther 2007 321: 116-127. Published online January 18, 2007; 10.1124/jpet.106.116863 [Abstract] [Full Text] [PDF] [Data Supplement]   

Zhihua Xie and Gregory M. Miller

Trace Amine-Associated Receptor 1 Is a Modulator of the Dopamine Transporter
J Pharmacol Exp Ther 2007 321: 128-136. Published online January 18, 2007; 10.1124/jpet.106.117382 [Abstract] [Full Text] [PDF]  

Kazue Hisaoka, Minoru Takebayashi, Mami Tsuchioka, Natsuko Maeda, Yoshihiro Nakata, and Shigeto Yamawaki

Antidepressants Increase Glial Cell Line-Derived Neurotrophic Factor Production through Monoamine-Independent Activation of Protein Tyrosine Kinase and Extracellular Signal-Regulated Kinase in Glial Cells
J Pharmacol Exp Ther 2007 321: 148-157. Published online January 8, 2007; 10.1124/jpet.106.116558 [Abstract] [Full Text] [PDF]  

Cedric Mombereau, Loic Lhuillier, Klemens Kaupmann, and John F. Cryan

GABA_B Receptor-Positive Modulation-Induced Blockade of the Rewarding Properties of Nicotine Is Associated with a Reduction in Nucleus Accumbens FosB Accumulation
J Pharmacol Exp Ther 2007 321: 172-177. Published online January 10, 2007; 10.1124/jpet.106.116228 [Abstract] [Full Text] [PDF]  

E. A. Reese, J. R. Bunzow, S. Arttamangkul, M. S. Sonders, and D. K. Grandy

Trace Amine-Associated Receptor 1 Displays Species-Dependent Stereoselectivity for Isomers of Methamphetamine, Amphetamine, and Para-Hydroxyamphetamine
J Pharmacol Exp Ther 2007 321: 178-186. Published online January 11, 2007; 10.1124/jpet.106.115402 [Abstract] [Full Text] [PDF]  

D. J. David, K. C. Klemenhagen, K. A. Holick, M. D. Saxe, I. Mendez, L. Santarelli, D. A. Craig, H. Zhong, C. J. Swanson, L. G. Hegde, X. I. Ping, D. Dong, M. R. Marzabadi, C. P. Gerald, and R. Hen

Efficacy of the MCHR1 Antagonist N-[3-(1-{[4-(3,4-Difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in Mouse Models of Anxiety and Depression following Acute and Chronic Administration Is Independent of Hippocampal Neurogenesis
J Pharmacol Exp Ther 2007 321: 237-248. Published online January 19, 2007; 10.1124/jpet.106.109678 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ji Man Han, Yong Jin Lee, So Yeon Lee, Eun Mee Kim, Younghye Moon, Ha Won Kim, and Onyou Hwang

Protective Effect of Sulforaphane against Dopaminergic Cell Death
J Pharmacol Exp Ther 2007 321: 249-256. Published online January 26, 2007; 10.1124/jpet.106.110866 [Abstract] [Full Text] [PDF]  

Munya A. Al-Fulaij, Yong Ren, Martin Beinborn, and Alan S. Kopin

Identification of Amino Acid Determinants of Dopamine 2 Receptor Synthetic Agonist Function
J Pharmacol Exp Ther 2007 321: 298-307. Published online January 4, 2007; 10.1124/jpet.106.116384 [Abstract] [Full Text] [PDF]  

Linda M. Rorick-Kehn, Bryan G. Johnson, Jennifer L. Burkey, Rebecca A. Wright, David O. Calligaro, Gerard J. Marek, Eric S. Nisenbaum, John T. Catlow, Ann E. Kingston, Deborah D. Giera, Marc F. Herin, James A. Monn, David L. McKinzie, and Darryle D. Schoepp

Pharmacological and Pharmacokinetic Properties of a Structurally Novel, Potent, and Selective Metabotropic Glutamate 2/3 Receptor Agonist: In Vitro Characterization of Agonist (–)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic Acid (LY404039)
J Pharmacol Exp Ther 2007 321: 308-317. Published online January 4, 2007; 10.1124/jpet.106.110809 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Jun Gu, Chong-Sheng Chen, Yuan Wei, Cheng Fang, Fang Xie, Kurunthachalam Kannan, Weizhu Yang, David J. Waxman, and Xinxin Ding

A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition
J Pharmacol Exp Ther 2007 321: 9-17. Published online January 11, 2007; 10.1124/jpet.106.118240 [Abstract] [Full Text] [PDF]  

André Tanel and Diana A. Averill-Bates

Inhibition of Acrolein-Induced Apoptosis by the Antioxidant N-Acetylcysteine
J Pharmacol Exp Ther 2007 321: 73-83. Published online January 4, 2007; 10.1124/jpet.106.114678 [Abstract] [Full Text] [PDF]  

Gary D. Minsavage and James F. Dillman, III

Bifunctional Alkylating Agent-Induced p53 and Nonclassical Nuclear Factor B Responses and Cell Death Are Altered by Caffeic Acid Phenethyl Ester: A Potential Role for Antioxidant/Electrophilic Response-Element Signaling
J Pharmacol Exp Ther 2007 321: 202-212. Published online January 4, 2007; 10.1124/jpet.106.116145 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "A Potent Immunomodulatory Compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxasole Acetic Acid, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice"
J Pharmacol Exp Ther 2007 321: 420. [Full Text] [PDF]  

Correction to "Sex Differences in Steroid Modulation of Ethanol Withdrawal in Male and Female Rats"
J Pharmacol Exp Ther 2007 321: 421. [Full Text] [PDF]  

Correction to "Modulation of Pro- and Antiapoptotic Molecules in Double-Positive (CD4⁺CD8⁺) Thymocytes following Dexamethasone Treatment"
J Pharmacol Exp Ther 2007 321: 422. [Full Text] [PDF]  

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