PERSPECTIVES IN PHARMACOLOGY:

Alvin V. Terry, Jr. and Sahebarao P. Mahadik

Time-Dependent Cognitive Deficits Associated with First and Second Generation Antipsychotics: Cholinergic Dysregulation as a Potential Mechanism
J Pharmacol Exp Ther 2007 320: 961-968. Published online September 11, 2006; 10.1124/jpet.106.106047 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Sunmee Wee, Sheila E. Specio, and George F. Koob

Effects of Dose and Session Duration on Cocaine Self-Administration in Rats
J Pharmacol Exp Ther 2007 320: 1134-1143. Published online January 3, 2007; 10.1124/jpet.106.113340 [Abstract] [Full Text] [PDF]  

Liza Leventhal, Valerie Smith, Geoffrey Hornby, Terrance H. Andree, Michael R. Brandt, and Kathryn E. Rogers

Differential and Synergistic Effects of Selective Norepinephrine and Serotonin Reuptake Inhibitors in Rodent Models of Pain
J Pharmacol Exp Ther 2007 320: 1178-1185. Published online December 1, 2006; 10.1124/jpet.106.109728 [Abstract] [Full Text] [PDF]  

Rajkumar J. Sevak, Wouter Koek, Aurelio Galli, and Charles P. France

Insulin Replacement Restores the Behavioral Effects of Quinpirole and Raclopride in Streptozotocin-Treated Rats
J Pharmacol Exp Ther 2007 320: 1216-1223. Published online December 14, 2006; 10.1124/jpet.106.115600 [Abstract] [Full Text] [PDF]  

István Gyertyán, Béla Kiss, Krisztina Gál, István Laszlovszky, Attila Horváth, Larisza I. Gémesi, Katalin Sághy, Gabriella Pásztor, Mária Zájer, Margit Kapás, Éva Ágai Csongor, György Domány, Károly Tihanyi, and Zsolt Szombathelyi

Effects of RGH-237 [N-{4-[4-(3-Aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an Orally Active, Selective Dopamine D₃ Receptor Partial Agonist in Animal Models of Cocaine Abuse
J Pharmacol Exp Ther 2007 320: 1268-1278. Published online December 14, 2006; 10.1124/jpet.106.107920 [Abstract] [Full Text] [PDF] [Data Supplement]   

CARDIOVASCULAR:

Valerie Croons, Wim Martinet, Arnold G. Herman, Jean-Pierre Timmermans, and Guido R. Y. De Meyer

Selective Clearance of Macrophages in Atherosclerotic Plaques by the Protein Synthesis Inhibitor Cycloheximide
J Pharmacol Exp Ther 2007 320: 986-993. Published online November 29, 2006; 10.1124/jpet.106.113944 [Abstract] [Full Text] [PDF]  

Masataka Oitate, Takashi Hirota, Makoto Takahashi, Takahiro Murai, Shin-ichi Miura, Akira Senoo, Tsunemichi Hosokawa, Tadahiro Oonishi, and Toshihiko Ikeda

Mechanism for Covalent Binding of Rofecoxib to Elastin of Rat Aorta
J Pharmacol Exp Ther 2007 320: 1195-1203. Published online December 12, 2006; 10.1124/jpet.106.114447 [Abstract] [Full Text] [PDF]  

Srinivas Ghatta, Radhika R. Tunstall, Sohail Kareem, Mohamed Rahman, and Stephen T. O'Rourke

Sirolimus Causes Relaxation of Human Vascular Smooth Muscle: A Novel Action of Sirolimus Mediated via ATP-Sensitive Potassium Channels
J Pharmacol Exp Ther 2007 320: 1204-1208. Published online December 12, 2006; 10.1124/jpet.106.115329 [Abstract] [Full Text] [PDF]  

Jean LeFebvre, Ayumi Shintani, Tebeb Gebretsadik, Jeffery R. Petro, Laine J. Murphey, and Nancy J. Brown

Bradykinin B₂ Receptor Does Not Contribute to Blood Pressure Lowering during AT₁ Receptor Blockade
J Pharmacol Exp Ther 2007 320: 1261-1267. Published online December 20, 2006; 10.1124/jpet.106.117259 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Yu Ishima, Tomohiro Sawa, Ulrich Kragh-Hansen, Yoichi Miyamoto, Sadaharu Matsushita, Takaaki Akaike, and Masaki Otagiri

S-Nitrosylation of Human Variant Albumin Liprizzi (R410C) Confers Potent Antibacterial and Cytoprotective Properties
J Pharmacol Exp Ther 2007 320: 969-977. Published online November 29, 2006; 10.1124/jpet.106.114959 [Abstract] [Full Text] [PDF]  

Jianfei Jiang, Igor Kurnikov, Natalia A. Belikova, Jingbo Xiao, Qing Zhao, Andrew A. Amoscato, Rebecca Braslau, Armido Studer, Mitchell P. Fink, Joel S. Greenberger, Peter Wipf, and Valerian E. Kagan

Structural Requirements for Optimized Delivery, Inhibition of Oxidative Stress, and Antiapoptotic Activity of Targeted Nitroxides
J Pharmacol Exp Ther 2007 320: 1050-1060. Published online December 19, 2006; 10.1124/jpet.106.114769 [Abstract] [Full Text] [PDF] [Data Supplement]   

Samina Salim and Douglas C. Eikenburg

Role of 90-kDa Heat Shock Protein (Hsp 90) and Protein Degradation in Regulating Neuronal Levels of G Protein-Coupled Receptor Kinase 3
J Pharmacol Exp Ther 2007 320: 1106-1112. Published online December 19, 2006; 10.1124/jpet.106.114835 [Abstract] [Full Text] [PDF]  

Daniel Lechner, Teresa Manhardt, Erika Bajna, Gary H. Posner, and Heide S. Cross

A 24-Phenylsulfone Analog of Vitamin D Inhibits 1,25-Dihydroxyvitamin D₃ Degradation in Vitamin D Metabolism-Competent Cells
J Pharmacol Exp Ther 2007 320: 1119-1126. Published online December 20, 2006; 10.1124/jpet.106.115451 [Abstract] [Full Text] [PDF]  

Dean A. Wiseman, Sean R. Werner, and Pamela L. Crowell

Cell Cycle Arrest by the Isoprenoids Perillyl Alcohol, Geraniol, and Farnesol Is Mediated by p21^Cip1 and p27^Kip1 in Human Pancreatic Adenocarcinoma Cells
J Pharmacol Exp Ther 2007 320: 1163-1170. Published online November 30, 2006; 10.1124/jpet.106.111666 [Abstract] [Full Text] [PDF]  

Mei Hong, Fanfan Zhou, Kevin Lee, and Guofeng You

The Putative Transmembrane Segment 7 of Human Organic Anion Transporter hOAT1 Dictates Transporter Substrate Binding and Stability
J Pharmacol Exp Ther 2007 320: 1209-1215. Published online December 13, 2006; 10.1124/jpet.106.117663 [Abstract] [Full Text] [PDF]  

Jin-Sun Park, Moon-Sook Woo, Dong-Hyun Kim, Jin-Won Hyun, Won-Ki Kim, Jae-Chul Lee, and Hee-Sun Kim

Anti-Inflammatory Mechanisms of Isoflavone Metabolites in Lipopolysaccharide-Stimulated Microglial Cells
J Pharmacol Exp Ther 2007 320: 1237-1245. Published online December 28, 2006; 10.1124/jpet.106.114322 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Stanislava Stosic-Grujicic, Ivana Cvetkovic, Katia Mangano, Massimo Fresta, Danijela Maksimovic-Ivanic, Ljubica Harhaji, Dusan Popadic, Miljana Momcilovic, Djordje Miljkovic, Joseph Kim, Yousef Al Abed, and Ferdinando Nicoletti

A Potent Immunomodulatory Compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxasole Acetic Acid, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice
J Pharmacol Exp Ther 2007 320: 1038-1049. Published online December 5, 2006; 10.1124/jpet.106.109272 [Abstract] [Full Text] [PDF] [Erratum]   

Marc Princivalle, Pierre Broqua, Richard White, Jessica Meyer, Gaell Mayer, Lucy Elliott, Ketil Bjarnason, Robert Haigh, and Christopher Yea

Rapid Suppression of Plasma Testosterone Levels and Tumor Growth in the Dunning Rat Model Treated with Degarelix, a New Gonadotropin-Releasing Hormone Antagonist
J Pharmacol Exp Ther 2007 320: 1113-1118. Published online December 19, 2006; 10.1124/jpet.106.112326 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Derek M. McKay, James L. Watson, Arthur Wang, Jackie Caldwell, David Prescott, Peter M. J. Ceponis, Vincenza Di Leo, and Jun Lu

Phosphatidylinositol 3'-Kinase Is a Critical Mediator of Interferon--Induced Increases in Enteric Epithelial Permeability
J Pharmacol Exp Ther 2007 320: 1013-1022. Published online December 18, 2006; 10.1124/jpet.106.113639 [Abstract] [Full Text] [PDF]  

Ruitang Deng, Dongfang Yang, Amy Radke, Jian Yang, and Bingfang Yan

The Hypolipidemic Agent Guggulsterone Regulates the Expression of Human Bile Salt Export Pump: Dominance of Transactivation over Farsenoid X Receptor-Mediated Antagonism
J Pharmacol Exp Ther 2007 320: 1153-1162. Published online November 29, 2006; 10.1124/jpet.106.113837 [Abstract] [Full Text] [PDF]  

S. Jamal Mustafa, Ahmed Nadeem, Ming Fan, Hongyan Zhong, Luiz Belardinelli, and Dewan Zeng

Effect of a Specific and Selective A_2B Adenosine Receptor Antagonist on Adenosine Agonist AMP and Allergen-Induced Airway Responsiveness and Cellular Influx in a Mouse Model of Asthma
J Pharmacol Exp Ther 2007 320: 1246-1251. Published online December 11, 2006; 10.1124/jpet.106.112250 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

John D. Bauer, Jeffrey A. Sunman, Michael S. Foster, Jeremy R. Thompson, Alison A. Ogonowski, Stephen J. Cutler, Sheldon W. May, and Stanley H. Pollock

Anti-Inflammatory Effects of 4-Phenyl-3-butenoic Acid and 5-(Acetylamino)-4-oxo-6-phenyl-2-hexenoic Acid Methyl Ester, Potential Inhibitors of Neuropeptide Bioactivation
J Pharmacol Exp Ther 2007 320: 1171-1177. Published online November 30, 2006; 10.1124/jpet.106.110940 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Judith Naud, Josée Michaud, Caroline Boisvert, Karine Desbiens, Francois A. Leblond, Andrew Mitchell, Christine Jones, Alain Bonnardeaux, and Vincent Pichette

Down-Regulation of Intestinal Drug Transporters in Chronic Renal Failure in Rats
J Pharmacol Exp Ther 2007 320: 978-985. Published online November 29, 2006; 10.1124/jpet.106.112631 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Seung-Won Park, Jae-Hyuk Yi, Guruwattan Miranpuri, Irawan Satriotomo, Kellie Bowen, Daniel K. Resnick, and Raghu Vemuganti

Thiazolidinedione Class of Peroxisome Proliferator-Activated Receptor Agonists Prevents Neuronal Damage, Motor Dysfunction, Myelin Loss, Neuropathic Pain, and Inflammation after Spinal Cord Injury in Adult Rats
J Pharmacol Exp Ther 2007 320: 1002-1012. Published online December 13, 2006; 10.1124/jpet.106.113472 [Abstract] [Full Text] [PDF] [Data Supplement]   

Elizabeth A. Hackler, Greg H. Turner, Paul J. Gresch, Saikat Sengupta, Ariel Y. Deutch, Malcolm J. Avison, John C. Gore, and Elaine Sanders-Bush

5-Hydroxytryptamine2C Receptor Contribution to m-Chlorophenylpiperazine and N-Methyl--carboline-3-carboxamide-Induced Anxiety-Like Behavior and Limbic Brain Activation
J Pharmacol Exp Ther 2007 320: 1023-1029. Published online November 30, 2006; 10.1124/jpet.106.113357 [Abstract] [Full Text] [PDF]  

John R. Atack, Paul Scott-Stevens, John S. Beech, Tim D. Fryer, Jessica L. Hughes, Marcel C. Cleij, Jean-Claude Baron, John C. Clark, Richard J. Hargreaves, and Franklin I. Aigbirhio

Comparison of Lorazepam [7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] Occupancy of Rat Brain -Aminobutyric Acid_A Receptors Measured Using in Vivo [³H]Flumazenil (8-Fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester) Binding and [¹¹C]Flumazenil Micro-Positron Emission Tomography
J Pharmacol Exp Ther 2007 320: 1030-1037. Published online December 12, 2006; 10.1124/jpet.106.114884 [Abstract] [Full Text] [PDF]  

Tooba A. Cheema, Veryan A. Pettigrew, and Stephen K. Fisher

Receptor Regulation of the Volume-Sensitive Efflux of Taurine and Iodide from Human SH-SY5Y Neuroblastoma Cells: Differential Requirements for Ca²⁺ and Protein Kinase C
J Pharmacol Exp Ther 2007 320: 1068-1077. Published online December 5, 2006; 10.1124/jpet.106.115741 [Abstract] [Full Text] [PDF]  

Gonzalo A. Carrasco, Louis D. Van de Kar, Cuihong Jia, Hao Xu, Zhuo Chen, Ritu Chadda, Francisca Garcia, Nancy A. Muma, and George Battaglia

Single Exposure to a Serotonin 1A Receptor Agonist, (+)8-Hydroxy-2-(di-n-propylamino)-tetralin, Produces a Prolonged Heterologous Desensitization of Serotonin 2A Receptors in Neuroendocrine Neurons in Vivo
J Pharmacol Exp Ther 2007 320: 1078-1086. Published online December 11, 2006; 10.1124/jpet.106.116004 [Abstract] [Full Text] [PDF]  

Akinori Iwashita, Yuko Muramatsu, Takao Yamazaki, Masakazu Muramoto, Yasuhiro Kita, Shunji Yamazaki, Kayoko Mihara, Akira Moriguchi, and Nobuya Matsuoka

Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor -Selective Agonists in Vitro and in Vivo
J Pharmacol Exp Ther 2007 320: 1087-1096. Published online December 13, 2006; 10.1124/jpet.106.115758 [Abstract] [Full Text] [PDF]  

Jenny L. Wiley, Mary M. O'Connell, Mary E. Tokarz, and M. Jerry Wright, Jr.

Pharmacological Effects of Acute and Repeated Administration of ⁹-Tetrahydrocannabinol in Adolescent and Adult Rats
J Pharmacol Exp Ther 2007 320: 1097-1105. Published online December 15, 2006; 10.1124/jpet.106.108126 [Abstract] [Full Text] [PDF]  

Khalid Benamar, Menachem Yondorf, Joseph J. Meissler, Ellen B. Geller, Ronald J. Tallarida, Toby K. Eisenstein, and Martin W. Adler

A Novel Role of Cannabinoids: Implication in the Fever Induced by Bacterial Lipopolysaccharide
J Pharmacol Exp Ther 2007 320: 1127-1133. Published online December 28, 2006; 10.1124/jpet.106.113159 [Abstract] [Full Text] [PDF]  

Ping Du, Kathleen M. Wood, Michele H. Rosner, David Cunningham, Barbara Tate, and Kieran F. Geoghegan

Dominance of Amyloid Precursor Protein Sequence over Host Cell Secretases in Determining -Amyloid Profiles Studies of Interspecies Variation and Drug Action by Internally Standardized Immunoprecipitation/Mass Spectrometry
J Pharmacol Exp Ther 2007 320: 1144-1152. Published online January 3, 2007; 10.1124/jpet.106.114561 [Abstract] [Full Text] [PDF]  

Prem N. Yadav, Kirti Chaturvedi, and Richard D. Howells

Inhibition of Agonist-Induced Down-Regulation of the -Opioid Receptor with a Proteasome Inhibitor Attenuates Opioid Tolerance in Human Embryonic Kidney 293 Cells
J Pharmacol Exp Ther 2007 320: 1186-1194. Published online December 11, 2006; 10.1124/jpet.106.113621 [Abstract] [Full Text] [PDF]  

Maarten van den Buuse and Andrea Gogos

Differential Effects of Antipsychotic Drugs on Serotonin-1A Receptor-Mediated Disruption of Prepulse Inhibition
J Pharmacol Exp Ther 2007 320: 1224-1236. Published online December 28, 2006; 10.1124/jpet.106.113084 [Abstract] [Full Text] [PDF]  

Joseph J. Raybon and Kathleen M. K. Boje

Pharmacokinetics and Pharmacodynamics of -Hydroxybutyric Acid during Tolerance in Rats: Effects on Extracellular Dopamine
J Pharmacol Exp Ther 2007 320: 1252-1260. Published online November 30, 2006; 10.1124/jpet.106.113886 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Ardhendu K. Mandal, Subhankar Das, Mukul K. Basu, Rohini N. Chakrabarti, and Nirmalendu Das

Hepatoprotective Activity of Liposomal Flavonoid against Arsenite-Induced Liver Fibrosis
J Pharmacol Exp Ther 2007 320: 994-1001. Published online November 30, 2006; 10.1124/jpet.106.114215 [Abstract] [Full Text] [PDF]  

Liping Wu and Philip R. Mayeux

Effects of the Inducible Nitric-Oxide Synthase Inhibitor L-N⁶-(1-Iminoethyl)-lysine on Microcirculation and Reactive Nitrogen Species Generation in the Kidney following Lipopolysaccharide Administration in Mice
J Pharmacol Exp Ther 2007 320: 1061-1067. Published online January 3, 2007; 10.1124/jpet.106.117184 [Abstract] [Full Text] [PDF]  

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