PERSPECTIVES IN PHARMACOLOGY:

Jonathan D. Urban, William P. Clarke, Mark von Zastrow, David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M. Sexton, Keith J. Miller, Michael Spedding, and Richard B. Mailman

Functional Selectivity and Classical Concepts of Quantitative Pharmacology
J Pharmacol Exp Ther 2007 320: 1-13. Published online June 27, 2006; 10.1124/jpet.106.104463 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

David J. Matson, Daniel C. Broom, Susan R. Carson, James Baldassari, John Kehne, and Daniel N. Cortright

Inflammation-Induced Reduction of Spontaneous Activity by Adjuvant: A Novel Model to Study the Effect of Analgesics in Rats
J Pharmacol Exp Ther 2007 320: 194-201. Published online October 18, 2006; 10.1124/jpet.106.109736 [Abstract] [Full Text] [PDF]  

Eduardo R. Butelman, Marek Mandau, Kevin Tidgewell, Thomas E. Prisinzano, Vadim Yuferov, and Mary Jeanne Kreek

Effects of Salvinorin A, a -Opioid Hallucinogen, on a Neuroendocrine Biomarker Assay in Nonhuman Primates with High -Receptor Homology to Humans
J Pharmacol Exp Ther 2007 320: 300-306. Published online October 23, 2006; 10.1124/jpet.106.112417 [Abstract] [Full Text] [PDF]  

P. E. Alele and L. L. Devaud

Sex Differences in Steroid Modulation of Ethanol Withdrawal in Male and Female Rats
J Pharmacol Exp Ther 2007 320: 427-436. Published online October 4, 2006; 10.1124/jpet.106.107896 [Abstract] [Full Text] [PDF] [Erratum]   

Karen L. Marquis, Annmarie L. Sabb, Sheree F. Logue, Julie A. Brennan, Michael J. Piesla, Tom A. Comery, Steven M. Grauer, Charles R. Ashby, Jr., Huy Q. Nguyen, Lee A. Dawson, James E. Barrett, Gary Stack, Herbert Y. Meltzer, Boyd L. Harrison, and Sharon Rosenzweig-Lipson

WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-Octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A Novel 5-Hydroxytryptamine 2C Receptor-Selective Agonist with Preclinical Antipsychotic-Like Activity
J Pharmacol Exp Ther 2007 320: 486-496. Published online October 12, 2006; 10.1124/jpet.106.106989 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Ying Xia, Sabzali Javadov, Tracey X. Gan, Theresa Pang, Michael A. Cook, and Morris Karmazyn

Distinct K_ATP Channels Mediate the Antihypertrophic Effects of Adenosine Receptor Activation in Neonatal Rat Ventricular Myocytes
J Pharmacol Exp Ther 2007 320: 14-21. Published online September 29, 2006; 10.1124/jpet.106.110494 [Abstract] [Full Text] [PDF]  

Chris Doe, Ross Bentley, David J. Behm, Robert Lafferty, Robert Stavenger, David Jung, Mark Bamford, Terry Panchal, Eugene Grygielko, Lois L. Wright, Gary K. Smith, Zunxuan Chen, Christine Webb, Sanjay Khandekar, Tracey Yi, Robert Kirkpatrick, Edward Dul, Larry Jolivette, Joseph P. Marino, Jr., Robert Willette, Dennis Lee, and Erding Hu

Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities
J Pharmacol Exp Ther 2007 320: 89-98. Published online October 3, 2006; 10.1124/jpet.106.110635 [Abstract] [Full Text] [PDF]  

Cristina Vidal, Almudena Gómez-Hernández, Eva Sánchez-Galán, Alejandro González, Luis Ortega, Juan Antonio Gómez-Gerique, José Tuñón, and Jesús Egido

Licofelone, a Balanced Inhibitor of Cyclooxygenase and 5-Lipoxygenase, Reduces Inflammation in a Rabbit Model of Atherosclerosis
J Pharmacol Exp Ther 2007 320: 108-116. Published online October 2, 2006; 10.1124/jpet.106.110361 [Abstract] [Full Text] [PDF]  

Keshari Thakali, Lauren Davenport, Gregory D. Fink, and Stephanie W. Watts

Cyclooxygenase, p38 Mitogen-Activated Protein Kinase (MAPK), Extracellular Signal-Regulated Kinase MAPK, Rho Kinase, and Src Mediate Hydrogen Peroxide-Induced Contraction of Rat Thoracic Aorta and Vena Cava
J Pharmacol Exp Ther 2007 320: 236-243. Published online September 26, 2006; 10.1124/jpet.106.110650 [Abstract] [Full Text] [PDF]  

G. Dever, C. M. Spickett, S. Kennedy, C. Rush, G. Tennant, A. Monopoli, and C. L. Wainwright

The Nitric Oxide-Donating Pravastatin Derivative, NCX 6550 [(1S-[1(S*, S*), 2, 6, 8-(R*), 8a]]-1,2,6,7,8,8a-Hexahydro-, , 6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic Acid 4-(Nitrooxy)butyl Ester)], Reduces Splenocyte Adhesion and Reactive Oxygen Species Generation in Normal and Atherosclerotic Mice
J Pharmacol Exp Ther 2007 320: 419-426. Published online September 27, 2006; 10.1124/jpet.106.109298 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Lihua Jin, Hiromi Sugiyama, Miki Takigawa, Daisuke Katagiri, Hideyuki Tomitori, Kazuhiro Nishimura, Navneet Kaur, Otto Phanstiel, IV, Mariko Kitajima, Hiromitsu Takayama, Tadashi Okawara, Keith Williams, Keiko Kashiwagi, and Kazuei Igarashi

Comparative Studies of Anthraquinone- and Anthracene-Tetraamines as Blockers of N-Methyl-D-aspartate Receptors
J Pharmacol Exp Ther 2007 320: 47-55. Published online October 18, 2006; 10.1124/jpet.106.110528 [Abstract] [Full Text] [PDF]  

Katalin Goda, Ferenc Fenyvesi, Zsolt Bacsó, Henrietta Nagy, Teréz Márián, Attila Megyeri, Zoltán Krasznai, István Juhász, Miklós Vecsernyés, and Gábor Szabó, Jr.

Complete Inhibition of P-glycoprotein by Simultaneous Treatment with a Distinct Class of Modulators and the UIC2 Monoclonal Antibody
J Pharmacol Exp Ther 2007 320: 81-88. Published online October 18, 2006; 10.1124/jpet.106.110155 [Abstract] [Full Text] [PDF]  

Jillian G. Baker and Stephen J. Hill

A Comparison of the Antagonist Affinities for the G_i- and G_s-Coupled States of the Human Adenosine A1-Receptor
J Pharmacol Exp Ther 2007 320: 218-228. Published online October 3, 2006; 10.1124/jpet.106.113589 [Abstract] [Full Text] [PDF]  

S. Husain, T. W. Shearer, and C. E. Crosson

Mechanisms Linking Adenosine A₁ Receptors and Extracellular Signal-Regulated Kinase 1/2 Activation in Human Trabecular Meshwork Cells
J Pharmacol Exp Ther 2007 320: 258-265. Published online October 2, 2006; 10.1124/jpet.106.110981 [Abstract] [Full Text] [PDF]  

Michelle L. Halls, Ross A. D. Bathgate, and Roger J. Summers

Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes
J Pharmacol Exp Ther 2007 320: 281-290. Published online October 25, 2006; 10.1124/jpet.106.113225 [Abstract] [Full Text] [PDF]  

Sandra De Barros, Alexia Zakaroff-Girard, Max Lafontan, Jean Galitzky, and Virginie Bourlier

Inhibition of Human Preadipocyte Proteasomal Activity by HIV Protease Inhibitors or Specific Inhibitor Lactacystin Leads to a Defect in Adipogenesis, Which Involves Matrix Metalloproteinase-9
J Pharmacol Exp Ther 2007 320: 291-299. Published online October 12, 2006; 10.1124/jpet.106.111849 [Abstract] [Full Text] [PDF]  

Justin H. Turner, Maria N. Garnovskaya, Sonya D. Coaxum, Tamara M. Vlasova, Margarita Yakutovich, David M. Lefler, and John R. Raymond

Ca²⁺-Calmodulin and Janus Kinase 2 Are Required for Activation of Sodium-Proton Exchange by the G_i-Coupled 5-Hydroxytryptamine_1a Receptor
J Pharmacol Exp Ther 2007 320: 314-322. Published online October 18, 2006; 10.1124/jpet.106.112581 [Abstract] [Full Text] [PDF]  

Ran Wu, Li Zhang, Martin S. Hoagland, and Hollie I. Swanson

Lack of the Aryl Hydrocarbon Receptor Leads to Impaired Activation of AKT/Protein Kinase B and Enhanced Sensitivity to Apoptosis Induced via the Intrinsic Pathway
J Pharmacol Exp Ther 2007 320: 448-457. Published online October 3, 2006; 10.1124/jpet.106.111773 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Jian Mei Li, Chun Tao Che, Clara B. S. Lau, Po Sing Leung, and Christopher H. K. Cheng

Desoxyrhaponticin (3,5-Dihydroxy-4'-methoxystilbene 3-O--D-glucoside) Inhibits Glucose Uptake in the Intestine and Kidney: In Vitro and in Vivo Studies
J Pharmacol Exp Ther 2007 320: 38-46. Published online October 12, 2006; 10.1124/jpet.106.111526 [Abstract] [Full Text] [PDF]  

Kenji Katsuno, Yoshikazu Fujimori, Yukiko Takemura, Masahiro Hiratochi, Fumiaki Itoh, Yoshimitsu Komatsu, Hideki Fujikura, and Masayuki Isaji

Sergliflozin, a Novel Selective Inhibitor of Low-Affinity Sodium Glucose Cotransporter (SGLT2), Validates the Critical Role of SGLT2 in Renal Glucose Reabsorption and Modulates Plasma Glucose Level
J Pharmacol Exp Ther 2007 320: 323-330. Published online October 18, 2006; 10.1124/jpet.106.110296 [Abstract] [Full Text] [PDF]  

M. J. Stevens, F. Li, V. R. Drel, O. I. Abatan, H. Kim, D. Burnett, D. Larkin, and I. G. Obrosova

Nicotinamide Reverses Neurological and Neurovascular Deficits in Streptozotocin Diabetic Rats
J Pharmacol Exp Ther 2007 320: 458-464. Published online October 4, 2006; 10.1124/jpet.106.109702 [Abstract] [Full Text] [PDF]  

Mario Rossi, Antonio Dimida, Maria Teresa Dell'anno, Maria Letizia Trincavelli, Patrizia Agretti, Franco Giorgi, Giovanni U. Corsini, Aldo Pinchera, Paolo Vitti, Massimo Tonacchera, and Roberto Maggio

The Thyroid Disruptor 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)-Ethane Appears to Be an Uncompetitive Inverse Agonist for the Thyrotropin Receptor
J Pharmacol Exp Ther 2007 320: 465-474. Published online October 24, 2006; 10.1124/jpet.106.113613 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Guang-Liang Jiang, Amelia Nieves, Wha Bin Im, David W. Old, Danny T. Dinh, and Larry Wheeler

The Prevention of Colitis by E Prostanoid Receptor 4 Agonist through Enhancement of Epithelium Survival and Regeneration
J Pharmacol Exp Ther 2007 320: 22-28. Published online September 28, 2006; 10.1124/jpet.106.111146 [Abstract] [Full Text] [PDF]  

Edwin K. Jackson, Zaichuan Mi, and Raghvendra K. Dubey

The Extracellular cAMP-Adenosine Pathway Significantly Contributes to the in Vivo Production of Adenosine
J Pharmacol Exp Ther 2007 320: 117-123. Published online October 6, 2006; 10.1124/jpet.106.112748 [Abstract] [Full Text] [PDF]  

Eric S. Tien, Kenji Matsui, Rick Moore, and Masahiko Negishi

The Nuclear Receptor Constitutively Active/Androstane Receptor Regulates Type 1 Deiodinase and Thyroid Hormone Activity in the Regenerating Mouse Liver
J Pharmacol Exp Ther 2007 320: 307-313. Published online October 18, 2006; 10.1124/jpet.106.112706 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Keith L. Kirkwood, Fei Li, Jill E. Rogers, Jodie Otremba, Derek D. Coatney, Jaclynn M. Kreider, Nisha J. D'Silva, Sarvajit Chakravarty, Sundeep Dugar, Linda S. Higgins, Andrew A. Protter, and Satyanarayana Medicherla

A p38 Selective Mitogen-Activated Protein Kinase Inhibitor Prevents Periodontal Bone Loss
J Pharmacol Exp Ther 2007 320: 56-63. Published online October 13, 2006; 10.1124/jpet.106.112466 [Abstract] [Full Text] [PDF]  

Chantal Cossette, Sinead E. Walsh, Seongjin Kim, Gue-Jae Lee, John A. Lawson, Sophie Bellone, Joshua Rokach, and William S. Powell

Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D₂ and 11-Methylene-PGD₂ on Human Eosinophils and Basophils
J Pharmacol Exp Ther 2007 320: 173-179. Published online October 13, 2006; 10.1124/jpet.106.111062 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Melanie N. Tallman, Kristini K. Miles, Fay K. Kessler, Judith N. Nielsen, Xianbin Tian, Joseph K. Ritter, and Philip C. Smith

The Contribution of Intestinal UDP-Glucuronosyltransferases in Modulating 7-Ethyl-10-hydroxy-camptothecin (SN-38)-Induced Gastrointestinal Toxicity in Rats
J Pharmacol Exp Ther 2007 320: 29-37. Published online September 26, 2006; 10.1124/jpet.106.110924 [Abstract] [Full Text] [PDF]  

Stephanie R. Faucette, Tong-Cun Zhang, Rick Moore, Tatsuya Sueyoshi, Curtis J. Omiecinski, Edward L. LeCluyse, Masahiko Negishi, and Hongbing Wang

Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers
J Pharmacol Exp Ther 2007 320: 72-80. Published online October 13, 2006; 10.1124/jpet.106.112136 [Abstract] [Full Text] [PDF]  

Takashi Ito, Masayuki Takahashi, Kenichi Sudo, and Yuichi Sugiyama

Marked Strain Differences in the Pharmacokinetics of an ₄₁ Integrin Antagonist, 4-[1-[3-Chloro-4-[N-(2-methylphenyl)-ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]-methoxybenzoic Acid (D01-4582), in Sprague-Dawley Rats Are Associated with Albumin Genetic Polymorphism
J Pharmacol Exp Ther 2007 320: 124-132. Published online October 12, 2006; 10.1124/jpet.106.111948 [Abstract] [Full Text] [PDF]  

Anand Balakrishnan, Naissan Hussainzada, Pablo Gonzalez, Marival Bermejo, Peter W. Swaan, and James E. Polli

Bias in Estimation of Transporter Kinetic Parameters from Overexpression Systems: Interplay of Transporter Expression Level and Substrate Affinity
J Pharmacol Exp Ther 2007 320: 133-144. Published online October 12, 2006; 10.1124/jpet.106.107433 [Abstract] [Full Text] [PDF]  

Takashi Iwanaga, Masanobu Sato, Tomoji Maeda, Toshio Ogihara, and Ikumi Tamai

Concentration-Dependent Mode of Interaction of Angiotensin II Receptor Blockers with Uric Acid Transporter
J Pharmacol Exp Ther 2007 320: 211-217. Published online October 16, 2006; 10.1124/jpet.106.112755 [Abstract] [Full Text] [PDF] [Data Supplement]   

Azza A. K. El-Sheikh, Jeroen J. M. W. van den Heuvel, Jan B. Koenderink, and Frans G. M. Russel

Interaction of Nonsteroidal Anti-Inflammatory Drugs with Multidrug Resistance Protein (MRP) 2/ABCC2- and MRP4/ABCC4-Mediated Methotrexate Transport
J Pharmacol Exp Ther 2007 320: 229-235. Published online September 27, 2006; 10.1124/jpet.106.110379 [Abstract] [Full Text] [PDF]  

Sevasti B. Koukouritaki, Mark T. Poch, Marilyn C. Henderson, Lisbeth K. Siddens, Sharon K. Krueger, Jonathan E. VanDyke, David E. Williams, Nicholas M. Pajewski, Tao Wang, and Ronald N. Hines

Identification and Functional Analysis of Common Human Flavin-Containing Monooxygenase 3 Genetic Variants
J Pharmacol Exp Ther 2007 320: 266-273. Published online October 18, 2006; 10.1124/jpet.106.112268 [Abstract] [Full Text] [PDF] [Data supplement]   

Steffen Baltes, Maren Fedrowitz, Carlos Luna Tortós, Heidrun Potschka, and Wolfgang Löscher

Valproic Acid Is Not a Substrate for P-glycoprotein or Multidrug Resistance Proteins 1 and 2 in a Number of in Vitro and in Vivo Transport Assays
J Pharmacol Exp Ther 2007 320: 331-343. Published online October 16, 2006; 10.1124/jpet.106.102491 [Abstract] [Full Text] [PDF]  

Ahmed A. Othman, Shariq A. Syed, Amy H. Newman, and Natalie D. Eddington

Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse
J Pharmacol Exp Ther 2007 320: 344-353. Published online September 26, 2006; 10.1124/jpet.106.111245 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Simon Akerman, Philip R. Holland, and Peter J. Goadsby

Cannabinoid (CB₁) Receptor Activation Inhibits Trigeminovascular Neurons
J Pharmacol Exp Ther 2007 320: 64-71. Published online October 3, 2006; 10.1124/jpet.106.106971 [Abstract] [Full Text] [PDF]  

Andrew B. Norman, Michael R. Tabet, Mantana K. Norman, William R. Buesing, Amadeo J. Pesce, and William J. Ball

A Chimeric Human/Murine Anticocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Mice
J Pharmacol Exp Ther 2007 320: 145-153. Published online October 5, 2006; 10.1124/jpet.106.111781 [Abstract] [Full Text] [PDF]  

Tsung-Ming Shih, Tami C. Rowland, and John H. McDonough

Anticonvulsants for Nerve Agent-Induced Seizures: The Influence of the Therapeutic Dose of Atropine
J Pharmacol Exp Ther 2007 320: 154-161. Published online October 2, 2006; 10.1124/jpet.106.111252 [Abstract] [Full Text] [PDF]  

Thomas W. Claydon, Moni Vaid, Saman Rezazadeh, Steven J. Kehl, and David Fedida

4-Aminopyridine Prevents the Conformational Changes Associated with P/C-Type Inactivation in Shaker Channels
J Pharmacol Exp Ther 2007 320: 162-172. Published online October 2, 2006; 10.1124/jpet.106.110411 [Abstract] [Full Text] [PDF]  

Laura E. O'Dell, Scott A. Chen, Ron T. Smith, Sheila E. Specio, Robert L. Balster, Neil E. Paterson, Athina Markou, Eric P. Zorrilla, and George F. Koob

Extended Access to Nicotine Self-Administration Leads to Dependence: Circadian Measures, Withdrawal Measures, and Extinction Behavior in Rats
J Pharmacol Exp Ther 2007 320: 180-193. Published online October 18, 2006; 10.1124/jpet.106.105270 [Abstract] [Full Text] [PDF]  

Gianfrancesco Cormaci, Tomohisa Mori, Teruo Hayashi, and Tsung-Ping Su

Protein Kinase A Activation Down-Regulates, Whereas Extracellular Signal-Regulated Kinase Activation Up-Regulates -1 Receptors in B-104 Cells: Implication for Neuroplasticity
J Pharmacol Exp Ther 2007 320: 202-210. Published online October 18, 2006; 10.1124/jpet.106.108415 [Abstract] [Full Text] [PDF]  

M. I. Damaj

Nicotinic Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Activation in the Spinal Cord
J Pharmacol Exp Ther 2007 320: 244-249. Published online October 13, 2006; 10.1124/jpet.106.111336 [Abstract] [Full Text] [PDF]  

M. I. Damaj, E. C. K. Siu, E. M. Sellers, R. F. Tyndale, and B. R. Martin

Inhibition of Nicotine Metabolism by Methoxysalen: Pharmacokinetic and Pharmacological Studies in Mice
J Pharmacol Exp Ther 2007 320: 250-257. Published online October 4, 2006; 10.1124/jpet.106.111237 [Abstract] [Full Text] [PDF]  

Andreas Leffler, Anne Reiprich, Durga P. Mohapatra, and Carla Nau

Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Na_v1.8 Than in TTX-Sensitive Na⁺ Channels
J Pharmacol Exp Ther 2007 320: 354-364. Published online September 27, 2006; 10.1124/jpet.106.109025 [Abstract] [Full Text] [PDF]  

X. Ligneau, D. Perrin, L. Landais, J.-C. Camelin, T. P. G. Calmels, I. Berrebi-Bertrand, J.-M. Lecomte, R. Parmentier, C. Anaclet, J.-S. Lin, V. Bertaina-Anglade, C. Drieu la Rochelle, F. d'Aniello, A. Rouleau, F. Gbahou, J.-M. Arrang, C. R. Ganellin, H. Stark, W. Schunack, and J.-C. Schwartz

BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H₃ Receptor: Preclinical Pharmacology
J Pharmacol Exp Ther 2007 320: 365-375. Published online September 27, 2006; 10.1124/jpet.106.111039 [Abstract] [Full Text] [PDF]  

Teresa K. Aman, Roh-Yu Shen, and Samir Haj-Dahmane

D₂-Like Dopamine Receptors Depolarize Dorsal Raphe Serotonin Neurons through the Activation of Nonselective Cationic Conductance
J Pharmacol Exp Ther 2007 320: 376-385. Published online September 27, 2006; 10.1124/jpet.106.111690 [Abstract] [Full Text] [PDF]  

Debomoy K. Lahiri, DeMao Chen, Bryan Maloney, Harold W. Holloway, Qian-sheng Yu, Tada Utsuki, Tony Giordano, Kumar Sambamurti, and Nigel H. Greig

The Experimental Alzheimer's Disease Drug Posiphen [(+)-Phenserine] Lowers Amyloid- Peptide Levels in Cell Culture and Mice
J Pharmacol Exp Ther 2007 320: 386-396. Published online September 26, 2006; 10.1124/jpet.106.112102 [Abstract] [Full Text] [PDF]  

Anthony C. Vernon, Virginia Zbarsky, Krishna P. Datla, David T. Dexter, and Martin J. Croucher

Selective Activation of Group III Metabotropic Glutamate Receptors by L-(+)-2-Amino-4-phosphonobutryic Acid Protects the Nigrostriatal System against 6-Hydroxydopamine Toxicity in Vivo
J Pharmacol Exp Ther 2007 320: 397-409. Published online September 29, 2006; 10.1124/jpet.106.108159 [Abstract] [Full Text] [PDF]  

Gary Lawrence, Jiafu Wang, C. K. N. Kwo Chion, K. Roger Aoki, and J. Oliver Dolly

Two Protein Trafficking Processes at Motor Nerve Endings Unveiled by Botulinum Neurotoxin E
J Pharmacol Exp Ther 2007 320: 410-418. Published online October 18, 2006; 10.1124/jpet.106.108829 [Abstract] [Full Text] [PDF]  

Ce Zhang and Gerard J. Marek

Group III Metabotropic Glutamate Receptor Agonists Selectively Suppress Excitatory Synaptic Currents in the Rat Prefrontal Cortex Induced by 5-Hydroxytryptamine_2A Receptor Activation
J Pharmacol Exp Ther 2007 320: 437-447. Published online October 4, 2006; 10.1124/jpet.106.107490 [Abstract] [Full Text] [PDF]  

David B. Wainscott, Sheila P. Little, Tinggui Yin, Yuan Tu, Vincent P. Rocco, John X. He, and David L. Nelson

Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1
J Pharmacol Exp Ther 2007 320: 475-485. Published online October 12, 2006; 10.1124/jpet.106.112532 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Marcus V. Terneus, K. Kelley Kiningham, A. Betts Carpenter, Sarah B. Sullivan, and Monica A. Valentovic

Comparison of S-Adenosyl-L-methionine and N-Acetylcysteine Protective Effects on Acetaminophen Hepatic Toxicity
J Pharmacol Exp Ther 2007 320: 99-107. Published online October 25, 2006; 10.1124/jpet.106.111872 [Abstract] [Full Text] [PDF]  

Jon E. Sprague, Xianmei Yang, Joni Sommers, Tracy L. Gilman, and Edward M. Mills

Roles of Norepinephrine, Free Fatty Acids, Thyroid Status, and Skeletal Muscle Uncoupling Protein 3 Expression in Sympathomimetic-Induced Thermogenesis
J Pharmacol Exp Ther 2007 320: 274-280. Published online September 29, 2006; 10.1124/jpet.106.107755 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "In Vitro Metabolism of (Nitroxy)butyl Ester Nitric Oxide-Releasing Compounds: Comparison with Glyceryl Trinitrate"
J Pharmacol Exp Ther 2007 320: 497. [Full Text] [PDF]  

Correction to "NAP Enhances Neurodevelopment of Newborn E-Deficient Mice Subjected to Hypoxia"
J Pharmacol Exp Ther 2007 320: 498. [Full Text] [PDF]  

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