BEHAVIORAL PHARMACOLOGY:

Su-Min Li, Bettye L. Campbell, and Jonathan L. Katz

Interactions of Cocaine with Dopamine Uptake Inhibitors or Dopamine Releasers in Rats Discriminating Cocaine
J Pharmacol Exp Ther 2006 317: 1088-1096. Published online February 14, 2006; 10.1124/jpet.105.100594 [Abstract] [Full Text] [PDF]  

Laurie H. L. Sellings, Lindsey E. McQuade, and Paul B. S. Clarke

Evidence for Multiple Sites within Rat Ventral Striatum Mediating Cocaine-Conditioned Place Preference and Locomotor Activation
J Pharmacol Exp Ther 2006 317: 1178-1187. Published online February 28, 2006; 10.1124/jpet.105.100339 [Abstract] [Full Text] [PDF]  

Mark C. Moffett, Jill Harley, Darlene Francis, Sonal P. Sanghani, Wilhelmina I. Davis, and Michael J. Kuhar

Maternal Separation and Handling Affects Cocaine Self-Administration in Both the Treated Pups as Adults and the Dams
J Pharmacol Exp Ther 2006 317: 1210-1218. Published online March 3, 2006; 10.1124/jpet.106.101139 [Abstract] [Full Text] [PDF]  

K. Michaelis, M. M. Hoffmann, S. Dreis, E. Herbert, R. N. Alyautdin, M. Michaelis, J. Kreuter, and K. Langer

Covalent Linkage of Apolipoprotein E to Albumin Nanoparticles Strongly Enhances Drug Transport into the Brain
J Pharmacol Exp Ther 2006 317: 1246-1253. Published online March 22, 2006; 10.1124/jpet.105.097139 [Abstract] [Full Text] [PDF]  

Johann Meunier, John Ieni, and Tangui Maurice

Antiamnesic and Neuroprotective Effects of Donepezil against Learning Impairments Induced in Mice by Exposure to Carbon Monoxide Gas
J Pharmacol Exp Ther 2006 317: 1307-1319. Published online March 21, 2006; 10.1124/jpet.106.101527 [Abstract] [Full Text] [PDF]  

Emily M. Jutkiewicz, Michelle G. Baladi, John E. Folk, Kenner C. Rice, and James H. Woods

The Convulsive and Electroencephalographic Changes Produced by Nonpeptidic -Opioid Agonists in Rats: Comparison with Pentylenetetrazol
J Pharmacol Exp Ther 2006 317: 1337-1348. Published online March 14, 2006; 10.1124/jpet.105.095810 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Vijay Kumar Kutala, Mahmood Khan, Rajarsi Mandal, Latha P. Ganesan, Susheela Tridandapani, Tamas Kalai, Kalman Hideg, and Periannan Kuppusamy

Attenuation of Myocardial Ischemia-Reperfusion Injury by Trimetazidine Derivatives Functionalized with Antioxidant Properties
J Pharmacol Exp Ther 2006 317: 921-928. Published online February 8, 2006; 10.1124/jpet.105.100834 [Abstract] [Full Text] [PDF]  

Samarjit Das, Arpad Tosaki, Debasis Bagchi, Nilanjana Maulik, and Dipak K. Das

Potentiation of a Survival Signal in the Ischemic Heart by Resveratrol through p38 Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1/cAMP Response Element-Binding Protein Signaling
J Pharmacol Exp Ther 2006 317: 980-988. Published online March 8, 2006; 10.1124/jpet.105.095133 [Abstract] [Full Text] [PDF]  

B. Lorkowska, M. Bartus, M. Franczyk, R. B. Kostogrys, J. Jawien, P. M. Pisulewski, and S. Chlopicki

Hypercholesterolemia Does Not Alter Endothelial Function in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2006 317: 1019-1026. Published online March 17, 2006; 10.1124/jpet.105.098798 [Abstract] [Full Text] [PDF]  

Sabzali Javadov, Delphine Baetz, Venkatesh Rajapurohitam, Asad Zeidan, Lorrie A. Kirshenbaum, and Morris Karmazyn

Antihypertrophic Effect of Na⁺/H⁺ Exchanger Isoform 1 Inhibition Is Mediated by Reduced Mitogen-Activated Protein Kinase Activation Secondary to Improved Mitochondrial Integrity and Decreased Generation of Mitochondrial-Derived Reactive Oxygen Species
J Pharmacol Exp Ther 2006 317: 1036-1043. Published online March 2, 2006; 10.1124/jpet.105.100107 [Abstract] [Full Text] [PDF]  

Armando Lagrutta, Jixin Wang, Bernard Fermini, and Joseph J. Salata

Novel, Potent Inhibitors of Human Kv1.5 K⁺ Channels and Ultrarapidly Activating Delayed Rectifier Potassium Current
J Pharmacol Exp Ther 2006 317: 1054-1063. Published online March 7, 2006; 10.1124/jpet.106.101162 [Abstract] [Full Text] [PDF]  

Tingcun Zhao, Pratik Parikh, Siva Bhashyam, Hakki Bolukoglu, Indu Poornima, You-Tang Shen, and Richard P. Shannon

Direct Effects of Glucagon-Like Peptide-1 on Myocardial Contractility and Glucose Uptake in Normal and Postischemic Isolated Rat Hearts
J Pharmacol Exp Ther 2006 317: 1106-1113. Published online February 17, 2006; 10.1124/jpet.106.100982 [Abstract] [Full Text] [PDF]  

Roberta Foresti, Sandip Bains, Filip Sulc, Patrick J. Farmer, Colin J. Green, and Roberto Motterlini

The Interaction of Nitric Oxide with Distinct Hemoglobins Differentially Amplifies Endothelial Heme Uptake and Heme Oxygenase-1 Expression
J Pharmacol Exp Ther 2006 317: 1125-1133. Published online February 22, 2006; 10.1124/jpet.105.097907 [Abstract] [Full Text] [PDF]  

Silvia Muro, Thomas Dziubla, Weining Qiu, John Leferovich, Xiumin Cui, Erik Berk, and Vladimir R. Muzykantov

Endothelial Targeting of High-Affinity Multivalent Polymer Nanocarriers Directed to Intercellular Adhesion Molecule 1
J Pharmacol Exp Ther 2006 317: 1161-1169. Published online February 27, 2006; 10.1124/jpet.105.098970 [Abstract] [Full Text] [PDF]  

So Youn Park, Jeong Hyun Lee, Chi Dae Kim, Won Suk Lee, Won Sun Park, Jin Han, Yong-Geun Kwak, Ki Young Kim, and Ki Whan Hong

Cilostazol Suppresses Superoxide Production and Expression of Adhesion Molecules in Human Endothelial Cells via Mediation of cAMP-Dependent Protein Kinase-Mediated Maxi-K Channel Activation
J Pharmacol Exp Ther 2006 317: 1238-1245. Published online March 17, 2006; 10.1124/jpet.105.098509 [Abstract] [Full Text] [PDF]  

Gracious R. Ross and Chandra Yallampalli

Endothelium-Independent Relaxation by Adrenomedullin in Pregnant Rat Mesenteric Artery: Role of cAMP-Dependent Protein Kinase A and Calcium-Activated Potassium Channels
J Pharmacol Exp Ther 2006 317: 1269-1275. Published online March 21, 2006; 10.1124/jpet.106.101790 [Abstract] [Full Text] [PDF]  

Wim Martinet, Guido R. Y. De Meyer, Jean-Pierre Timmermans, Arnold G. Herman, and Mark M. Kockx

Macrophages but Not Smooth Muscle Cells Undergo Benzyloxycarbonyl-Val-Ala-DL-Asp(O-Methyl)-Fluoromethylketone-Induced Nonapoptotic Cell Death Depending on Receptor-Interacting Protein 1 Expression: Implications for the Stabilization of Macrophage-Rich Atherosclerotic Plaques
J Pharmacol Exp Ther 2006 317: 1356-1364. Published online March 14, 2006; 10.1124/jpet.106.102970 [Abstract] [Full Text] [PDF] [Data Supplement]   

CELLULAR AND MOLECULAR:

Jayant J. Khandare, Pooja Chandna, Yang Wang, Vitaly P. Pozharov, and Tamara Minko

Novel Polymeric Prodrug with Multivalent Components for Cancer Therapy
J Pharmacol Exp Ther 2006 317: 929-937. Published online February 9, 2006; 10.1124/jpet.105.098855 [Abstract] [Full Text] [PDF]  

Aarti N. Desai, Samina Salim, Kelly M. Standifer, and Douglas C. Eikenburg

Involvement of G Protein-Coupled Receptor Kinase (GRK) 3 and GRK2 in Down-Regulation of the _2B-Adrenoceptor
J Pharmacol Exp Ther 2006 317: 1027-1035. Published online March 13, 2006; 10.1124/jpet.105.098996 [Abstract] [Full Text] [PDF]  

Yu-Jin Won, Kum Whang, In Deok Kong, Kyu-Sang Park, Joong-Woo Lee, and Seong-Woo Jeong

Expression Profiles of High Voltage-Activated Calcium Channels in Sympathetic and Parasympathetic Pelvic Ganglion Neurons Innervating the Urogenital System
J Pharmacol Exp Ther 2006 317: 1064-1071. Published online February 8, 2006; 10.1124/jpet.105.098210 [Abstract] [Full Text] [PDF]  

Mark R. Dowling, Jonathon M. Willets, David C. Budd, Steven J. Charlton, Stefan R. Nahorski, and R. A. John Challiss

A Single Point Mutation (N514Y) in the Human M₃ Muscarinic Acetylcholine Receptor Reveals Differences in the Properties of Antagonists: Evidence for Differential Inverse Agonism
J Pharmacol Exp Ther 2006 317: 1134-1142. Published online February 17, 2006; 10.1124/jpet.106.101246 [Abstract] [Full Text] [PDF]  

Can E. Senkal, Suriyan Ponnusamy, Michael J. Rossi, Kamala Sundararaj, Zdzislaw Szulc, Jacek Bielawski, Alicja Bielawska, Mario Meyer, Bengu Cobanoglu, Serap Koybasi, Debajyoti Sinha, Terry A. Day, Lina M. Obeid, Yusuf A. Hannun, and Besim Ogretmen

Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo
J Pharmacol Exp Ther 2006 317: 1188-1199. Published online March 1, 2006; 10.1124/jpet.106.101949 [Abstract] [Full Text] [PDF]  

Curtis R. Kelly and Najam A. Sharif

Pharmacological Evidence for a Functional Serotonin-2B Receptor in a Human Uterine Smooth Muscle Cell Line
J Pharmacol Exp Ther 2006 317: 1254-1261. Published online March 3, 2006; 10.1124/jpet.105.100172 [Abstract] [Full Text] [PDF]  

Sheng-Xue Xie, Anja Kraus, Prasanta Ghorai, Qi-Zhuang Ye, Sigurd Elz, Armin Buschauer, and Roland Seifert

N¹-(3-Cyclohexylbutanoyl)-N²-[3-(1H-imidazol-4-yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H₁- and H₂-Receptors
J Pharmacol Exp Ther 2006 317: 1262-1268. Published online March 22, 2006; 10.1124/jpet.106.102897 [Abstract] [Full Text] [PDF]  

Wei Xu, Su-In Yoon, Peng Huang, Yulin Wang, Chongguang Chen, Parkson Lee-Gau Chong, and Lee-Yuan Liu-Chen

Localization of the Opioid Receptor in Lipid Rafts
J Pharmacol Exp Ther 2006 317: 1295-1306. Published online February 27, 2006; 10.1124/jpet.105.099507 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Ho Lun Wong, Reina Bendayan, Andrew M. Rauth, Hui Yi Xue, Karlo Babakhanian, and Xiao Yu Wu

A Mechanistic Study of Enhanced Doxorubicin Uptake and Retention in Multidrug Resistant Breast Cancer Cells Using a Polymer-Lipid Hybrid Nanoparticle System
J Pharmacol Exp Ther 2006 317: 1372-1381. Published online March 17, 2006; 10.1124/jpet.106.101154 [Abstract] [Full Text] [PDF]  

Shigeru Kawakami, Yoshitaka Ito, Pensri Charoensit, Fumiyoshi Yamashita, and Mitsuru Hashida

Evaluation of Proinflammatory Cytokine Production Induced by Linear and Branched Polyethylenimine/Plasmid DNA Complexes in Mice
J Pharmacol Exp Ther 2006 317: 1382-1390. Published online March 7, 2006; 10.1124/jpet.105.100669 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Matteo Fornai, Corrado Blandizzi, Luca Antonioli, Rocchina Colucci, Nunzia Bernardini, Cristina Segnani, Fabrizio De Ponti, and Mario Del Tacca

Differential Role of Cyclooxygenase 1 and 2 Isoforms in the Modulation of Colonic Neuromuscular Function in Experimental Inflammation
J Pharmacol Exp Ther 2006 317: 938-945. Published online February 10, 2006; 10.1124/jpet.105.098350 [Abstract] [Full Text] [PDF]  

Xanthi I. Couroucli, Yanhong W. Liang, Weiwu Jiang, Roberto Barrios, and Bhagavatula Moorthy

Attenuation of Oxygen-Induced Abnormal Lung Maturation in Rats by Retinoic Acid: Possible Role of Cytochrome P4501A Enzymes
J Pharmacol Exp Ther 2006 317: 946-954. Published online February 23, 2006; 10.1124/jpet.105.100677 [Abstract] [Full Text] [PDF]  

Joris H. De Maeyer, Nicolaas H. Prins, Jan A. J. Schuurkes, and Romain A. Lefebvre

Differential Effects of 5-Hydroxytryptamine₄ Receptor Agonists at Gastric versus Cardiac Receptors: An Operational Framework to Explain and Quantify Organ-Specific Behavior
J Pharmacol Exp Ther 2006 317: 955-964. Published online February 24, 2006; 10.1124/jpet.106.101329 [Abstract] [Full Text] [PDF]  

Edwin K. Jackson, Lefteris C. Zacharia, Mingdi Zhang, Delbert G. Gillespie, Chongxue Zhu, and Raghvendra K. Dubey

cAMP-Adenosine Pathway in the Proximal Tubule
J Pharmacol Exp Ther 2006 317: 1219-1229. Published online March 9, 2006; 10.1124/jpet.106.101360 [Abstract] [Full Text] [PDF]  

John H. Dubinion, Zaichuan Mi, and Edwin K. Jackson

Role of Renal Sympathetic Nerves in Regulating Renovascular Responses to Angiotensin II in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2006 317: 1330-1336. Published online March 14, 2006; 10.1124/jpet.106.101279 [Abstract] [Full Text] [PDF]  

Weibiao Cao, Karen M. Harnett, and Victor E. Pricolo

NK2 Receptor-Mediated Spontaneous Phasic Contractions in Normal and Ulcerative Colitis Human Sigmoid Colon
J Pharmacol Exp Ther 2006 317: 1349-1355. Published online March 22, 2006; 10.1124/jpet.105.097030 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Travis J. Jerde, William S. Mellon, Dale E. Bjorling, and Stephen Y. Nakada

Evaluation of Urothelial Stretch-Induced Cyclooxygenase-2 Expression in Novel Human Cell Culture and Porcine in Vivo Ureteral Obstruction Models
J Pharmacol Exp Ther 2006 317: 965-972. Published online February 28, 2006; 10.1124/jpet.105.099184 [Abstract] [Full Text] [PDF]  

Danyi Wen, Yuhua Nong, Jennifer G. Morgan, Pranoti Gangurde, Andrew Bielecki, Jennifer DaSilva, Marie Keaveney, Hong Cheng, Chris Fraser, Lisa Schopf, Michael Hepperle, Geraldine Harriman, Bruce D. Jaffee, Timothy D. Ocain, and Yajun Xu

A Selective Small Molecule IB Kinase Inhibitor Blocks Nuclear Factor B-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells
J Pharmacol Exp Ther 2006 317: 989-1001. Published online March 8, 2006; 10.1124/jpet.105.097584 [Abstract] [Full Text] [PDF]  

Daniele Bani, Lucia Giannini, Anna Ciampa, Emanuela Masini, Ylenia Suzuki, Marta Menegazzi, Silvia Nistri, and Hisanori Suzuki

Epigallocatechin-3-Gallate Reduces Allergen-Induced Asthma-Like Reaction in Sensitized Guinea Pigs
J Pharmacol Exp Ther 2006 317: 1002-1011. Published online March 8, 2006; 10.1124/jpet.106.102178 [Abstract] [Full Text] [PDF]  

Gabriel Mbalaviele, Gary Anderson, Amy Jones, Pamela De Ciechi, Steve Settle, Steve Mnich, Mark Thiede, Yousef Abu-Amer, Joseph Portanova, and Joseph Monahan

Inhibition of p38 Mitogen-Activated Protein Kinase Prevents Inflammatory Bone Destruction
J Pharmacol Exp Ther 2006 317: 1044-1053. Published online February 24, 2006; 10.1124/jpet.105.100362 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Edna F. Choo, Daniel Kurnik, Mordechai Muszkat, Tadashi Ohkubo, Sheila D. Shay, James N. Higginbotham, Hartmut Glaeser, Richard B. Kim, Alastair J. J. Wood, and Grant R. Wilkinson

Differential in Vivo Sensitivity to Inhibition of P-glycoprotein Located in Lymphocytes, Testes, and the Blood-Brain Barrier
J Pharmacol Exp Ther 2006 317: 1012-1018. Published online March 14, 2006; 10.1124/jpet.105.099648 [Abstract] [Full Text] [PDF]  

Hikaru Saito, Hiroyuki Hirano, Hiroshi Nakagawa, Takeaki Fukami, Keisuke Oosumi, Kaori Murakami, Hiroko Kimura, Takayuki Kouchi, Mami Konomi, Eriko Tao, Noboru Tsujikawa, Shigeki Tarui, Makoto Nagakura, Masako Osumi, and Toshihisa Ishikawa

A New Strategy of High-Speed Screening and Quantitative Structure-Activity Relationship Analysis to Evaluate Human ATP-Binding Cassette Transporter ABCG2-Drug Interactions
J Pharmacol Exp Ther 2006 317: 1114-1124. Published online February 17, 2006; 10.1124/jpet.105.099036 [Abstract] [Full Text] [PDF]  

Stephanie R. Faucette, Tatsuya Sueyoshi, Cornelia M. Smith, Masahiko Negishi, Edward L. LeCluyse, and Hongbing Wang

Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor
J Pharmacol Exp Ther 2006 317: 1200-1209. Published online March 2, 2006; 10.1124/jpet.105.098160 [Abstract] [Full Text] [PDF]  

Li J. Yu, Yue Chen, Judith L. Treadway, R. Kirk McPherson, Scott C. McCoid, E. Michael Gibbs, and Dennis J. Hoover

Establishment of Correlation between in Vitro Enzyme Binding Potency and in Vivo Pharmacological Activity: Application to Liver Glycogen Phosphorylase a Inhibitors
J Pharmacol Exp Ther 2006 317: 1230-1237. Published online March 14, 2006; 10.1124/jpet.105.100545 [Abstract] [Full Text] [PDF]  

Jing Zhang, Min Huang, Su Guan, Hui-Chang Bi, Ying Pan, Wei Duan, Sui Yung Chan, Xiao Chen, Yun-Han Hong, Jin-Song Bian, Hong-Yuan Yang, and Shufeng Zhou

A Mechanistic Study of the Intestinal Absorption of Cryptotanshinone, the Major Active Constituent of Salvia miltiorrhiza
J Pharmacol Exp Ther 2006 317: 1285-1294. Published online February 23, 2006; 10.1124/jpet.105.100701 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Yi Zhang, Ling Wang, Jiang Li, and Xiao-Liang Wang

2-(1-Hydroxypentyl)-benzoate Increases Cerebral Blood Flow and Reduces Infarct Volume in Rats Model of Transient Focal Cerebral Ischemia
J Pharmacol Exp Ther 2006 317: 973-979. Published online March 9, 2006; 10.1124/jpet.105.098517 [Abstract] [Full Text] [PDF]  

Robert E. Blair, Laxmikant S. Deshpande, Sompong Sombati, Katherine W. Falenski, Billy R. Martin, and Robert J. DeLorenzo

Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus
J Pharmacol Exp Ther 2006 317: 1072-1078. Published online February 9, 2006; 10.1124/jpet.105.100354 [Abstract] [Full Text] [PDF]  

Yoshimasa Yamaguchi, Hitoshi Miyashita, Hiroko Tsunekawa, Akihiro Mouri, Hyoung-Chun Kim, Kenichi Saito, Toshiyuki Matsuno, Seiichiro Kawashima, and Toshitaka Nabeshima

Effects of a Novel Cognitive Enhancer, Spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on Learning Impairments Induced by Amyloid-_1–40 in the Rat
J Pharmacol Exp Ther 2006 317: 1079-1087. Published online February 10, 2006; 10.1124/jpet.105.098640 [Abstract] [Full Text] [PDF]  

Fabio Longordo, Marco Feligioni, Greta Chiaramonte, Pier Filippo Sbaffi, Maurizio Raiteri, and Anna Pittaluga

The Human Immunodeficiency Virus-1 Protein Transactivator of Transcription Up-Regulates N-Methyl-D-aspartate Receptor Function by Acting at Metabotropic Glutamate Receptor 1 Receptors Coexisting on Human and Rat Brain Noradrenergic Neurones
J Pharmacol Exp Ther 2006 317: 1097-1105. Published online February 17, 2006; 10.1124/jpet.105.099630 [Abstract] [Full Text] [PDF]  

Teresa Iuvone, Daniele De Filippis, Giuseppe Esposito, Alessandra D'Amico, and Angelo A. Izzo

The Spice Sage and Its Active Ingredient Rosmarinic Acid Protect PC12 Cells from Amyloid- Peptide-Induced Neurotoxicity
J Pharmacol Exp Ther 2006 317: 1143-1149. Published online February 22, 2006; 10.1124/jpet.105.099317 [Abstract] [Full Text] [PDF]  

Jakub Fichna, Katarzyna Gach, Mariola Piestrzeniewicz, Emmanuel Burgeon, Jeroen Poels, Jozef Vanden Broeck, and Anna Janecka

Functional Characterization of Opioid Receptor Ligands by Aequorin Luminescence-Based Calcium Assay
J Pharmacol Exp Ther 2006 317: 1150-1154. Published online February 23, 2006; 10.1124/jpet.105.099986 [Abstract] [Full Text] [PDF]  

Chunyi Zhou, Cheng Xiao, Joseph J. McArdle, and Jiang Hong Ye

Mefloquine Enhances Nigral -Aminobutyric Acid Release via Inhibition of Cholinesterase
J Pharmacol Exp Ther 2006 317: 1155-1160. Published online February 24, 2006; 10.1124/jpet.106.101923 [Abstract] [Full Text] [PDF]  

Ying Chen, Nicole Menendez-Roche, and Emanuele Sher

Differential Modulation by the GABA_B Receptor Allosteric Potentiator 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of Synaptic Transmission in the Rat Hippocampal CA1 Area
J Pharmacol Exp Ther 2006 317: 1170-1177. Published online February 28, 2006; 10.1124/jpet.105.099176 [Abstract] [Full Text] [PDF]  

Ran Zhang, Natalie A. White, Ferenc S. Soti, William R. Kem, and Tina K. Machu

N-Terminal Domains in Mouse and Human 5-Hydroxytryptamine_3A Receptors Confer Partial Agonist and Antagonist Properties to Benzylidene Analogs of Anabaseine
J Pharmacol Exp Ther 2006 317: 1276-1284. Published online March 21, 2006; 10.1124/jpet.106.101485 [Abstract] [Full Text] [PDF]  

G. La Rana, R. Russo, P. Campolongo, M. Bortolato, R. A. Mangieri, V. Cuomo, A. Iacono, G. Mattace Raso, R. Meli, D. Piomelli, and A. Calignano

Modulation of Neuropathic and Inflammatory Pain by the Endocannabinoid Transport Inhibitor AM404 [N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]
J Pharmacol Exp Ther 2006 317: 1365-1371. Published online March 1, 2006; 10.1124/jpet.105.100792 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Kai He, Jason Huang, Carl F. Lagenaur, and Elias Aizenman

Methylisothiazolinone, A Neurotoxic Biocide, Disrupts the Association of Src Family Tyrosine Kinases with Focal Adhesion Kinase in Developing Cortical Neurons
J Pharmacol Exp Ther 2006 317: 1320-1329. Published online March 17, 2006; 10.1124/jpet.106.103044 [Abstract] [Full Text] [PDF]  

Aparajita Dey and Arthur I. Cederbaum

Geldanamycin, an Inhibitor of Hsp90, Potentiates Cytochrome P4502E1-Mediated Toxicity in HepG2 Cells
J Pharmacol Exp Ther 2006 317: 1391-1399. Published online March 2, 2006; 10.1124/jpet.106.101808 [Abstract] [Full Text] [PDF]  

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