ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Clifford W. Mason, Vanessa M. D'Souza, Lisa M. Bareford, Mitch A. Phelps, Abhijit Ray, and Peter W. Swaan

Recognition, Cointernalization, and Recycling of an Avian Riboflavin Carrier Protein in Human Placental Trophoblasts
J Pharmacol Exp Ther 2006 317: 465-472. Published online January 6, 2006; 10.1124/jpet.105.096149 [Abstract] [Full Text] [PDF]  

Sonia Mesia-Vela, Rosa I. Sanchez, Kenneth R. Reuhl, Allan H. Conney, and Frederick C. Kauffman

Phenobarbital Treatment Inhibits the Formation of Estradiol-Dependent Mammary Tumors in the August-Copenhagen Irish Rat
J Pharmacol Exp Ther 2006 317: 590-597. Published online January 18, 2006; 10.1124/jpet.105.096867 [Abstract] [Full Text] [PDF]  

P. R. Pentel, M. B. Dufek, S. A. Roiko, M. G. LeSage, and D. E. Keyler

Differential Effects of Passive Immunization with Nicotine-Specific Antibodies on the Acute and Chronic Distribution of Nicotine to Brain in Rats
J Pharmacol Exp Ther 2006 317: 660-666. Published online January 11, 2006; 10.1124/jpet.105.097873 [Abstract] [Full Text] [PDF]  

Haritha Mandula, Jagan Mohan R. Parepally, Rose Feng, and Quentin R. Smith

Role of Site-Specific Binding to Plasma Albumin in Drug Availability to Brain
J Pharmacol Exp Ther 2006 317: 667-675. Published online January 12, 2006; 10.1124/jpet.105.097402 [Abstract] [Full Text] [PDF]  

Peng Hsiao, Lucy Sasongko, Jeanne M. Link, David A. Mankoff, Mark Muzi, Ann C. Collier, and Jashvant D. Unadkat

Verapamil P-glycoprotein Transport across the Rat Blood-Brain Barrier: Cyclosporine, a Concentration Inhibition Analysis, and Comparison with Human Data
J Pharmacol Exp Ther 2006 317: 704-710. Published online January 13, 2006; 10.1124/jpet.105.097931 [Abstract] [Full Text] [PDF]  

Mirco Govoni, Simona Casagrande, Raffaella Maucci, Valerio Chiroli, and Paola Tocchetti

In Vitro Metabolism of (Nitrooxy)butyl Ester Nitric Oxide-Releasing Compounds: Comparison with Glyceryl Trinitrate
J Pharmacol Exp Ther 2006 317: 752-761. Published online January 19, 2006; 10.1124/jpet.105.097469 [Abstract] [Full Text] [PDF] [Erratum]   

Kun Cheng, Zhaoyang Ye, Ramareddy V. Guntaka, and Ram I. Mahato

Enhanced Hepatic Uptake and Bioactivity of Type 1(I) Collagen Gene Promoter-Specific Triplex-Forming Oligonucleotides after Conjugation with Cholesterol
J Pharmacol Exp Ther 2006 317: 797-805. Published online February 1, 2006; 10.1124/jpet.105.100347 [Abstract] [Full Text] [PDF]  

Hao-Jie Zhu, Jun-Sheng Wang, John S. Markowitz, Jennifer L. Donovan, Bryan B. Gibson, Holly A. Gefroh, and C. Lindsay DeVane

Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana
J Pharmacol Exp Ther 2006 317: 850-857. Published online January 26, 2006; 10.1124/jpet.105.098541 [Abstract] [Full Text] [PDF]  

Margaret M. Doherty, Karen Poon, Carol Tsang, and K. Sandy Pang

Transport Is Not Rate-Limiting in Morphine Glucuronidation in the Single-Pass Perfused Rat Liver Preparation
J Pharmacol Exp Ther 2006 317: 890-900. Published online February 7, 2006; 10.1124/jpet.105.100446 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

S. Stevens Negus

Choice between Heroin and Food in Nondependent and Heroin-Dependent Rhesus Monkeys: Effects of Naloxone, Buprenorphine, and Methadone
J Pharmacol Exp Ther 2006 317: 711-723. Published online February 2, 2006; 10.1124/jpet.105.095380 [Abstract] [Full Text] [PDF]  

Janet R. Nicholson, Götz Kohler, Florian Schaerer, Claudia Senn, Philipp Weyermann, and Karl G. Hofbauer

Peripheral Administration of a Melanocortin 4-Receptor Inverse Agonist Prevents Loss of Lean Body Mass in Tumor-Bearing Mice
J Pharmacol Exp Ther 2006 317: 771-777. Published online January 25, 2006; 10.1124/jpet.105.097725 [Abstract] [Full Text] [PDF]  

Ian C. Webb, Michael S. Pollock, and Ralph E. Mistlberger

Modafinil [2-[(Diphenylmethyl)sulfinyl]acetamide] and Circadian Rhythms in Syrian Hamsters: Assessment of the Chronobiotic Potential of a Novel Alerting Compound
J Pharmacol Exp Ther 2006 317: 882-889. Published online February 3, 2006; 10.1124/jpet.105.099010 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Lioubov I. Brueggemann, Daniel R. Markun, Kyle K. Henderson, Leanne L. Cribbs, and Kenneth L. Byron

Pharmacological and Electrophysiological Characterization of Store-Operated Currents and Capacitative Ca²⁺ Entry in Vascular Smooth Muscle Cells
J Pharmacol Exp Ther 2006 317: 488-499. Published online January 13, 2006; 10.1124/jpet.105.095067 [Abstract] [Full Text] [PDF]  

Nazareno Paolocci, Barbara Tavazzi, Roberto Biondi, Yehezkiel A. Gluzband, Angela Maria Amorini, Carlo G. Tocchetti, Mehrdad Hejazi, Patrizio M. Caturegli, Jan Kajstura, Giuseppe Lazzarino, and David A. Kass

Metalloproteinase Inhibitor Counters High-Energy Phosphate Depletion and AMP Deaminase Activity Enhancing Ventricular Diastolic Compliance in Subacute Heart Failure
J Pharmacol Exp Ther 2006 317: 506-513. Published online January 25, 2006; 10.1124/jpet.105.099168 [Abstract] [Full Text] [PDF]  

I. Tong Mak, Joanna J. Chmielinska, Lucie Nedelec, Armida Torres, and William B. Weglicki

D-Propranolol Attenuates Lysosomal Iron Accumulation and Oxidative Injury in Endothelial Cells
J Pharmacol Exp Ther 2006 317: 522-528. Published online February 2, 2006; 10.1124/jpet.105.097709 [Abstract] [Full Text] [PDF]  

Steve Xydas, Aftab R. Kherani, Jonathan S. Chang, Stefan Klotz, Ilan Hay, Christopher J. Mutrie, Garrett W. Moss, Anguo Gu, Allison R. Schulman, Daqing Gao, Debora Hu, Ed X. Wu, Chiming Wei, Mehmet C. Oz, and Jie Wang

₂-Adrenergic Stimulation Attenuates Left Ventricular Remodeling, Decreases Apoptosis, and Improves Calcium Homeostasis in a Rodent Model of Ischemic Cardiomyopathy
J Pharmacol Exp Ther 2006 317: 553-561. Published online January 18, 2006; 10.1124/jpet.105.099432 [Abstract] [Full Text] [PDF]  

Dong Ju Son, Seong Jong Ha, Ho Sueb Song, Yong Lim, Yeo Pyo Yun, Jae Woong Lee, Dong Cheul Moon, Young Hyun Park, Byeoung Soo Park, Min Jong Song, and Jin Tae Hong

Melittin Inhibits Vascular Smooth Muscle Cell Proliferation through Induction of Apoptosis via Suppression of Nuclear Factor-B and Akt Activation and Enhancement of Apoptotic Protein Expression
J Pharmacol Exp Ther 2006 317: 627-634. Published online January 9, 2006; 10.1124/jpet.105.095901 [Abstract] [Full Text] [PDF]  

Courtney P. Judkins, Christopher G. Sobey, Thuy T. Dang, Alyson A. Miller, Gregory J. Dusting, and Grant R. Drummond

NADPH-Induced Contractions of Mouse Aorta Do Not Involve NADPH Oxidase: A Role for P2X Receptors
J Pharmacol Exp Ther 2006 317: 644-650. Published online January 11, 2006; 10.1124/jpet.105.096610 [Abstract] [Full Text] [PDF] [Data Supplement]   

Peter Zahradka, Brenda Wright, Melissa Fuerst, Natalia Yurkova, Katerina Molnar, and Carla G. Taylor

Peroxisome Proliferator-Activated Receptor and Ligands Differentially Affect Smooth Muscle Cell Proliferation and Migration
J Pharmacol Exp Ther 2006 317: 651-659. Published online January 11, 2006; 10.1124/jpet.105.096271 [Abstract] [Full Text] [PDF]  

J. Callebert, J. M. Esteve, P. Hervé, K. Peoc'h, C. Tournois, L. Drouet, J. M. Launay, and L. Maroteaux

Evidence for a Control of Plasma Serotonin Levels by 5-Hydroxytryptamine_2B Receptors in Mice
J Pharmacol Exp Ther 2006 317: 724-731. Published online February 3, 2006; 10.1124/jpet.105.098269 [Abstract] [Full Text] [PDF] [Data Supplement]   

Zhigang Yu, Valerie Y. Ng, Ping Su, Marguerite M. Engler, Mary B. Engler, Yong Huang, Emil Lin, and Deanna L. Kroetz

Induction of Renal Cytochrome P450 Arachidonic Acid Epoxygenase Activity by Dietary -Linolenic Acid
J Pharmacol Exp Ther 2006 317: 732-738. Published online January 18, 2006; 10.1124/jpet.105.098558 [Abstract] [Full Text] [PDF]  

Klaudia Budzyn, Michelle Paull, Philip D. Marley, and Christopher G. Sobey

Segmental Differences in the Roles of Rho-Kinase and Protein Kinase C in Mediating Vasoconstriction
J Pharmacol Exp Ther 2006 317: 791-796. Published online February 1, 2006; 10.1124/jpet.105.100040 [Abstract] [Full Text] [PDF]  

Jae B. Park and Norberta Schoene

Clovamide-Type Phenylpropenoic Acid Amides, N-Coumaroyldopamine and N-Caffeoyldopamine, Inhibit Platelet-Leukocyte Interactions via Suppressing P-Selectin Expression
J Pharmacol Exp Ther 2006 317: 813-819. Published online February 14, 2006; 10.1124/jpet.105.097337 [Abstract] [Full Text] [PDF]  

Carola Buccellati, Angelo Sala, Giuseppe Rossoni, Valérie Capra, G. Enrico Rovati, Antonio Di Gennaro, Giancarlo Folco, Susanna Colli, and Cesare Casagrande

Pharmacological Characterization of 2NTX-99 [4-Methoxy-N¹-(4-trans-nitrooxycyclohexyl)-N³-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a Potential Antiatherothrombotic Agent with Antithromboxane and Nitric Oxide Donor Activity in Platelet and Vascular Preparations
J Pharmacol Exp Ther 2006 317: 830-837. Published online January 6, 2006; 10.1124/jpet.105.097170 [Abstract] [Full Text] [PDF]  

Jun Guo, Hongying Gang, and Shetuan Zhang

Molecular Determinants of Cocaine Block of Human Ether-á-go-go-Related Gene Potassium Channels
J Pharmacol Exp Ther 2006 317: 865-874. Published online January 5, 2006; 10.1124/jpet.105.098103 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Joanna Lipecka, Caroline Norez, Noura Bensalem, Maryvonne Baudouin-Legros, Gabrielle Planelles, Frédéric Becq, Aleksander Edelman, and Noélie Davezac

Rescue of F508-CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) by Curcumin: Involvement of the Keratin 18 Network
J Pharmacol Exp Ther 2006 317: 500-505. Published online January 19, 2006; 10.1124/jpet.105.097667 [Abstract] [Full Text] [PDF]  

Xiao-Yan Chu, John R. Strauss, Michele A. Mariano, Jing Li, Deborah J. Newton, Xiaoxin Cai, Regina W. Wang, Jocelyn Yabut, Dylan P. Hartley, David C. Evans, and Raymond Evers

Characterization of Mice Lacking the Multidrug Resistance Protein Mrp2 (Abcc2)
J Pharmacol Exp Ther 2006 317: 579-589. Published online January 18, 2006; 10.1124/jpet.105.098665 [Abstract] [Full Text] [PDF]  

Michael Saborowski, Gerd A. Kullak-Ublick, and Jyrki J. Eloranta

The Human Organic Cation Transporter-1 Gene Is Transactivated by Hepatocyte Nuclear Factor-4
J Pharmacol Exp Ther 2006 317: 778-785. Published online January 25, 2006; 10.1124/jpet.105.099929 [Abstract] [Full Text] [PDF]  

Mary J. Clark, Cheryse A. Furman, Timra D. Gilson, and John R. Traynor

Comparison of the Relative Efficacy and Potency of µ-Opioid Agonists to Activate G_i/o Proteins Containing a Pertussis Toxin-Insensitive Mutation
J Pharmacol Exp Ther 2006 317: 858-864. Published online January 25, 2006; 10.1124/jpet.105.096818 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Anna Martirosyan, Stephen Leonard, Xianglin Shi, Brian Griffith, Peter Gannett, and Jeannine Strobl

Actions of a Histone Deacetylase Inhibitor NSC3852 (5-Nitroso-8-quinolinol) Link Reactive Oxygen Species to Cell Differentiation and Apoptosis in MCF-7 Human Mammary Tumor Cells
J Pharmacol Exp Ther 2006 317: 546-552. Published online February 23, 2006; 10.1124/jpet.105.096891 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Marjan Fatholahi, Yiwen Xiang, Yuzhi Wu, Yuan Li, Lin Wu, Arvinder K. Dhalla, Luiz Belardinelli, and John C. Shryock

A Novel Partial Agonist of the A₁ -Adenosine Receptor and Evidence of Receptor Homogeneity in Adipocytes
J Pharmacol Exp Ther 2006 317: 676-684. Published online January 12, 2006; 10.1124/jpet.105.099119 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Almut Grenz, Detlef Baier, Fotios Petroktistis, Manfred Wehrmann, Christoph Köhle, Martin Schenk, Michael Sessler, Christoph H. Gleiter, Fred Fandrich, and Hartmut Osswald

Theophylline Improves Early Allograft Function in Rat Kidney Transplantation
J Pharmacol Exp Ther 2006 317: 473-479. Published online January 12, 2006; 10.1124/jpet.105.096917 [Abstract] [Full Text] [PDF]  

Rick Greupink, Hester I. Bakker, Wilma Bouma, Catharina Reker-Smit, Dirk K. F. Meijer, Leonie Beljaars, and Klaas Poelstra

The Antiproliferative Drug Doxorubicin Inhibits Liver Fibrosis in Bile Duct-Ligated Rats and Can Be Selectively Delivered to Hepatic Stellate Cells in Vivo
J Pharmacol Exp Ther 2006 317: 514-521. Published online January 26, 2006; 10.1124/jpet.105.099499 [Abstract] [Full Text] [PDF]  

Carlos Medina, Paul Jurasz, Maria Jose Santos-Martinez, Soon Seog Jeong, Timothy Mitsky, Ridong Chen, and Marek W. Radomski

Platelet Aggregation-Induced by Caco-2 Cells: Regulation by Matrix Metalloproteinase-2 and Adenosine Diphosphate
J Pharmacol Exp Ther 2006 317: 739-745. Published online January 19, 2006; 10.1124/jpet.105.098384 [Abstract] [Full Text] [PDF]  

Cliff Battram, Steven J. Charlton, Bernard Cuenoud, Mark R. Dowling, Robin A. Fairhurst, David Farr, John R. Fozard, Juliet R. Leighton-Davies, Christine A. Lewis, Lorraine McEvoy, Robert J. Turner, and Alexandre Trifilieff

In Vitro and in Vivo Pharmacological Characterization of 5-[(R)-2-(5,6-Diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (Indacaterol), a Novel Inhaled ₂ Adrenoceptor Agonist with a 24-h Duration of Action
J Pharmacol Exp Ther 2006 317: 762-770. Published online January 24, 2006; 10.1124/jpet.105.098251 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Hoon-Suk Cha, David L. Boyle, Tomoyuki Inoue, Reineke Schoot, Paul P. Tak, Polly Pine, and Gary S. Firestein

A Novel Spleen Tyrosine Kinase Inhibitor Blocks c-Jun N-Terminal Kinase-Mediated Gene Expression in Synoviocytes
J Pharmacol Exp Ther 2006 317: 571-578. Published online February 1, 2006; 10.1124/jpet.105.097436 [Abstract] [Full Text] [PDF]  

Hugh T. Abey, David P. Fairlie, James D. Moffatt, Rowan W. Balzary, and Thomas M. Cocks

Protease-Activated Receptor-2 Peptides Activate Neurokinin-1 Receptors in the Mouse Isolated Trachea
J Pharmacol Exp Ther 2006 317: 598-605. Published online January 24, 2006; 10.1124/jpet.105.097121 [Abstract] [Full Text] [PDF]  

Rowan W. Balzary and Thomas M. Cocks

Lipopolysaccharide Induces Epithelium- and Prostaglandin E₂-Dependent Relaxation of Mouse Isolated Trachea through Activation of Cyclooxygenase (COX)-1 and COX-2
J Pharmacol Exp Ther 2006 317: 806-812. Published online February 7, 2006; 10.1124/jpet.105.097634 [Abstract] [Full Text] [PDF]  

Gautham K. Rao and Norbert E. Kaminski

Cannabinoid-Mediated Elevation of Intracellular Calcium: A Structure-Activity Relationship
J Pharmacol Exp Ther 2006 317: 820-829. Published online January 25, 2006; 10.1124/jpet.105.100503 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Norton H. Neff, Trina A. Wemlinger, Anne-Marie Duchemin, and Maria Hadjiconstantinou

Clozapine Modulates Aromatic L-Amino Acid Decarboxylase Activity in Mouse Striatum
J Pharmacol Exp Ther 2006 317: 480-487. Published online January 13, 2006; 10.1124/jpet.105.097972 [Abstract] [Full Text] [PDF]  

Feng Han, Yasufumi Shirasaki, and Kohji Fukunaga

3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydro-chloride 3.5 Hydrate (DY-9760e) Is Neuroprotective in Rat Microsphere Embolism: Role of the Cross-Talk between Calpain and Caspase-3 through Calpastatin
J Pharmacol Exp Ther 2006 317: 529-536. Published online February 8, 2006; 10.1124/jpet.105.095018 [Abstract] [Full Text] [PDF]  

Nobukazu Kakui, Jiro Tanaka, Yuji Tabata, Kenji Asai, Naomi Masuda, Takako Miyara, Yuko Nakatani, Fukuichi Ohsawa, Naoyuki Nishikawa, Masaharu Sugai, Makoto Suzuki, Kozo Aoki, and Hiroshi Kitaguchi

Pharmacological Characterization and Feeding-Suppressive Property of FMS586 [3-(5,6,7,8-Tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea Hydrochloride], a Novel, Selective, and Orally Active Antagonist for Neuropeptide Y Y5 Receptor
J Pharmacol Exp Ther 2006 317: 562-570. Published online January 25, 2006; 10.1124/jpet.105.099705 [Abstract] [Full Text] [PDF]  

Tangui Maurice, Johann Meunier, Bihua Feng, John Ieni, and Daniel T. Monaghan

Interaction with ₁ Protein, but Not N-Methyl-D-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil
J Pharmacol Exp Ther 2006 317: 606-614. Published online January 5, 2006; 10.1124/jpet.105.097394 [Abstract] [Full Text] [PDF]  

Anni-Maija Linden, M. Isabel Aller, Elli Leppä, Olga Vekovischeva, Teemu Aitta-aho, Emma L. Veale, Alistair Mathie, Per Rosenberg, William Wisden, and Esa R. Korpi

The in Vivo Contributions of TASK-1-Containing Channels to the Actions of Inhalation Anesthetics, the ₂ Adrenergic Sedative Dexmedetomidine, and Cannabinoid Agonists
J Pharmacol Exp Ther 2006 317: 615-626. Published online January 5, 2006; 10.1124/jpet.105.098525 [Abstract] [Full Text] [PDF]  

Anne M. Heacock, Michael S. Dodd, and Stephen K. Fisher

Regulation of Volume-Sensitive Osmolyte Efflux from Human SH-SY5Y Neuroblastoma Cells following Activation of Lysophospholipid Receptors
J Pharmacol Exp Ther 2006 317: 685-693. Published online January 13, 2006; 10.1124/jpet.105.098467 [Abstract] [Full Text] [PDF]  

Rafal M. Kaminski, Herbert Marini, Pavel I. Ortinski, Stefano Vicini, and Michael A. Rogawski

The Pheromone Androstenol (5-Androst-16-en-3-ol) Is a Neurosteroid Positive Modulator of GABA_A Receptors
J Pharmacol Exp Ther 2006 317: 694-703. Published online January 13, 2006; 10.1124/jpet.105.098319 [Abstract] [Full Text] [PDF]  

J. E. Gibbs, Z. Gaffen, and S. A. Thomas

Nevirapine Uptake into the Central Nervous System of the Guinea Pig: An in Situ Brain Perfusion Study
J Pharmacol Exp Ther 2006 317: 746-751. Published online January 19, 2006; 10.1124/jpet.105.098459 [Abstract] [Full Text] [PDF]  

Jonathan D. Best, Mark T. Jay, Franklin Otu, Ian Churcher, Michael Reilly, Pablo Morentin-Gutierrez, Christine Pattison, Tim Harrison, Mark S. Shearman, and John R. Atack

In Vivo Characterization of A(40) Changes in Brain and Cerebrospinal Fluid Using the Novel -Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the Rat
J Pharmacol Exp Ther 2006 317: 786-790. Published online January 27, 2006; 10.1124/jpet.105.100271 [Abstract] [Full Text] [PDF]  

Brian J. Piper, Huyen L. Vu, Mina G. Safain, Andrew J. Oliver, and Jerrold S. Meyer

Repeated Adolescent 3,4-Methylenedioxymethamphetamine (MDMA) Exposure in Rats Attenuates the Effects of a Subsequent Challenge with MDMA or a 5-Hydroxytryptamine_1A Receptor Agonist
J Pharmacol Exp Ther 2006 317: 838-849. Published online January 24, 2006; 10.1124/jpet.105.095760 [Abstract] [Full Text] [PDF]  

Yu Hasegawa, Motohiro Morioka, Shu Hasegawa, Jun Matsumoto, Takayuki Kawano, Yutaka Kai, Shigetoshi Yano, Kohji Fukunaga, and Jun-ichi Kuratsu

Therapeutic Time Window and Dose Dependence of Neuroprotective Effects of Sodium Orthovanadate following Transient Middle Cerebral Artery Occlusion in Rats
J Pharmacol Exp Ther 2006 317: 875-881. Published online February 3, 2006; 10.1124/jpet.105.096677 [Abstract] [Full Text] [PDF]  

Lei Tang, Pradeep K. Shukla, Lili X. Wang, and Zaijie Jim Wang

Reversal of Morphine Antinociceptive Tolerance and Dependence by the Acute Supraspinal Inhibition of Ca²⁺/Calmodulin-Dependent Protein Kinase II
J Pharmacol Exp Ther 2006 317: 901-909. Published online February 27, 2006; 10.1124/jpet.105.097733 [Abstract] [Full Text] [PDF] [Data Supplement]   

Kimberly E. Vanover, David M. Weiner, Malath Makhay, Isaac Veinbergs, Luis R. Gardell, Jelveh Lameh, Andria L. Del Tredici, Fabrice Piu, Hans H. Schiffer, Thomas R. Ott, Ethan S. Burstein, Allan K. Uldam, Mikkel B. Thygesen, Nathalie Schlienger, Carl Magnus Andersson, Thomas Y. Son, Scott C. Harvey, Susan B. Powell, Mark A. Geyer, Bo-Ragner Tolf, Mark R. Brann, and Robert E. Davis

Pharmacological and Behavioral Profile of N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) Carbamide (2R,3R)-Dihydroxybutanedioate (2:1) (ACP-103), a Novel 5-Hydroxytryptamine_2A Receptor Inverse Agonist
J Pharmacol Exp Ther 2006 317: 910-918. Published online February 9, 2006; 10.1124/jpet.105.097006 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Jeffrey S. Moffit, Lauren M. Aleksunes, Jonathan M. Maher, George L. Scheffer, Curtis D. Klaassen, and José E. Manautou

Induction of Hepatic Transporters Multidrug Resistance-Associated Proteins (Mrp) 3 and 4 by Clofibrate Is Regulated by Peroxisome Proliferator-Activated Receptor
J Pharmacol Exp Ther 2006 317: 537-545. Published online February 8, 2006; 10.1124/jpet.105.093765 [Abstract] [Full Text] [PDF] [Data Supplement]   

James P. Luyendyk, Lois D. Lehman-McKeeman, David M. Nelson, Vasanthi M. Bhaskaran, Timothy P. Reilly, Bruce D. Car, Glenn H. Cantor, Xiaomin Deng, Jane F. Maddox, Patricia E. Ganey, and Robert A. Roth

Coagulation-Dependent Gene Expression and Liver Injury in Rats Given Lipopolysaccharide with Ranitidine but Not with Famotidine
J Pharmacol Exp Ther 2006 317: 635-643. Published online January 9, 2006; 10.1124/jpet.105.096305 [Abstract] [Full Text] [PDF] [Data Supplement]   

ERRATA:

Correction to "Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Conditions: A Suggested Solution Based on in Vivo Occupancy"
J Pharmacol Exp Ther 2006 317: 919. [Full Text] [PDF]  

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