ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Mahesh N. Samtani, Nancy A. Pyszczynski, Debra C. DuBois, Richard R. Almon, and William J. Jusko

Modeling Glucocorticoid-Mediated Fetal Lung Maturation: I. Temporal Patterns of Corticosteroids in Rat Pregnancy
J Pharmacol Exp Ther 2006 317: 117-126. Published online December 21, 2005; 10.1124/jpet.105.095851 [Abstract] [Full Text] [PDF]  

Mahesh N. Samtani, Nancy A. Pyszczynski, Debra C. DuBois, Richard R. Almon, and William J. Jusko

Modeling Glucocorticoid-Mediated Fetal Lung Maturation: II. Temporal Patterns of Gene Expression in Fetal Rat Lung
J Pharmacol Exp Ther 2006 317: 127-138. Published online December 21, 2005; 10.1124/jpet.105.095869 [Abstract] [Full Text] [PDF]  

Naoki Kobayashi, Atsutoshi Ikesue, Sumit Majumdar, and Teruna J. Siahaan

Inhibition of E-Cadherin-Mediated Homotypic Adhesion of Caco-2 Cells: A Novel Evaluation Assay for Peptide Activities in Modulating Cell-Cell Adhesion
J Pharmacol Exp Ther 2006 317: 309-316. Published online December 21, 2005; 10.1124/jpet.105.097535 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Indre Bileviciute-Ljungar, Mariana Spetea, Yan Guo, Johannes Schütz, Petra Windisch, and Helmut Schmidhammer

Peripherally Mediated Antinociception of the µ-Opioid Receptor Agonist 2-[(4,5-Epoxy-3-hydroxy-14-methoxy-17-methylmorphinan-6-yl)amino]acetic Acid (HS-731) after Subcutaneous and Oral Administration in Rats with Carrageenan-Induced Hindpaw Inflammation
J Pharmacol Exp Ther 2006 317: 220-227. Published online December 8, 2005; 10.1124/jpet.105.096032 [Abstract] [Full Text] [PDF]  

Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Hiroyuki Mizoguchi, Yukihiro Noda, and Toshitaka Nabeshima

Inhibition of Neprilysin by Infusion of Thiorphan into the Hippocampus Causes an Accumulation of Amyloid and Impairment of Learning and Memory
J Pharmacol Exp Ther 2006 317: 334-340. Published online December 28, 2005; 10.1124/jpet.105.095687 [Abstract] [Full Text] [PDF]  

Sevil Yasar, Zuzana Justinova, Sun-Hee Lee, Roman Stefanski, Steven R. Goldberg, and Gianluigi Tanda

Metabolic Transformation Plays a Primary Role in the Psychostimulant-Like Discriminative-Stimulus Effects of Selegiline [(R)-(–)-Deprenyl]
J Pharmacol Exp Ther 2006 317: 387-394. Published online December 13, 2005; 10.1124/jpet.105.096263 [Abstract] [Full Text] [PDF]  

Wouter Koek, Weibin Chen, Susan L. Mercer, Andrew Coop, and Charles P. France

Discriminative Stimulus Effects of -Hydroxybutyrate: Role of Training Dose
J Pharmacol Exp Ther 2006 317: 409-417. Published online December 5, 2005; 10.1124/jpet.105.096909 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Yiqiang Zhou, Hui Huang, Hsin-Hsin Chang, Juan Du, Jing Feng Wu, Cong-Yi Wang, and Mong-Heng Wang

Induction of Renal 20-Hydroxyeicosatetraenoic Acid by Clofibrate Attenuates High-Fat Diet-Induced Hypertension in Rats
J Pharmacol Exp Ther 2006 317: 11-18. Published online December 8, 2005; 10.1124/jpet.105.095356 [Abstract] [Full Text] [PDF]  

Kai Wang, Zhongmin Zhou, Ming Zhang, Liming Fan, Farhad Forudi, Xiaorong Zhou, Wu Qu, A. Michael Lincoff, Ann Marie Schmidt, Eric J. Topol, and Marc S. Penn

Peroxisome Proliferator-Activated Receptor Down-Regulates Receptor for Advanced Glycation End Products and Inhibits Smooth Muscle Cell Proliferation in a Diabetic and Nondiabetic Rat Carotid Artery Injury Model
J Pharmacol Exp Ther 2006 317: 37-43. Published online December 20, 2005; 10.1124/jpet.105.095125 [Abstract] [Full Text] [PDF]  

Takayuki Miki, Tetsuji Miura, Toshiyuki Yano, Akari Takahashi, Jun Sakamoto, Masaya Tanno, Hironori Kobayashi, Yoshihiro Ikeda, Masahiro Nishihara, Kazuyuki Naitoh, Katsuhiko Ohori, and Kazuaki Shimamoto

Alteration in Erythropoietin-Induced Cardioprotective Signaling by Postinfarct Ventricular Remodeling
J Pharmacol Exp Ther 2006 317: 68-75. Published online December 23, 2005; 10.1124/jpet.105.095745 [Abstract] [Full Text] [PDF]  

Jeffery D. MacPherson, Timothy D. Gillespie, Heather A. Dunkerley, Donald H. Maurice, and Brian M. Bennett

Inhibition of Phosphodiesterase 5 Selectively Reverses Nitrate Tolerance in the Venous Circulation
J Pharmacol Exp Ther 2006 317: 188-195. Published online December 5, 2005; 10.1124/jpet.105.094763 [Abstract] [Full Text] [PDF]  

James K. Hennan, Robert E. Swillo, Gwen A. Morgan, James C. Keith, Jr., Robert G. Schaub, Robert P. Smith, Hal S. Feldman, Ketil Haugan, Joel Kantrowitz, Phil J. Wang, Aqel Abu-Qare, John Butera, Bjarne D. Larsen, and David L. Crandall

Rotigaptide (ZP123) Prevents Spontaneous Ventricular Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open-Chest Dogs
J Pharmacol Exp Ther 2006 317: 236-243. Published online December 12, 2005; 10.1124/jpet.105.096933 [Abstract] [Full Text] [PDF]  

Cleber E. Teixeira, Fernanda B. M. Priviero, and R. Clinton Webb

Molecular Mechanisms Underlying Rat Mesenteric Artery Vasorelaxation Induced by the Nitric Oxide-Independent Soluble Guanylyl Cyclase Stimulators BAY 41-2272 [5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine] and YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole]
J Pharmacol Exp Ther 2006 317: 258-266. Published online December 13, 2005; 10.1124/jpet.105.095752 [Abstract] [Full Text] [PDF]  

Yoshio Tanaka, Guanghua Tang, Kei Takizawa, Kazuoki Otsuka, Mansoureh Eghbali, Min Song, Kazuhide Nishimaru, Koki Shigenobu, Katsuo Koike, Enrico Stefani, and Ligia Toro

K_v Channels Contribute to Nitric Oxide- and Atrial Natriuretic Peptide-Induced Relaxation of a Rat Conduit Artery
J Pharmacol Exp Ther 2006 317: 341-354. Published online January 4, 2006; 10.1124/jpet.105.096115 [Abstract] [Full Text] [PDF]  

Rui Zhang, Brian Rodrigues, and Kathleen M. MacLeod

Lysophosphatidylcholine Potentiates Phenylephrine Responses in Rat Mesenteric Arterial Bed through Modulation of Thromboxane A₂
J Pharmacol Exp Ther 2006 317: 355-361. Published online January 4, 2006; 10.1124/jpet.105.097964 [Abstract] [Full Text] [PDF]  

Ilaria Zanotti, Francesco Potì, Elda Favari, Knut R. Steffensen, Jan-Åke Gustafsson, and Franco Bernini

Pitavastatin Effect on ATP Binding Cassette A1-Mediated Lipid Efflux from Macrophages: Evidence for Liver X Receptor (LXR)-Dependent and LXR-Independent Mechanisms of Activation by cAMP
J Pharmacol Exp Ther 2006 317: 395-401. Published online January 13, 2006; 10.1124/jpet.105.093930 [Abstract] [Full Text] [PDF]  

Saoirse E. O'Sullivan, David A. Kendall, and Michael D. Randall

Further Characterization of the Time-Dependent Vascular Effects of ⁹-Tetrahydrocannabinol
J Pharmacol Exp Ther 2006 317: 428-438. Published online December 13, 2005; 10.1124/jpet.105.095828 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Sarvesh Jajoo, Debashree Mukherjea, Sandeep Pingle, Yuko Sekino, and Vickram Ramkumar

Induction of Adenosine A₁ Receptor Expression by Pertussis Toxin via an Adenosine 5'-Diphosphate Ribosylation-Independent Pathway
J Pharmacol Exp Ther 2006 317: 1-10. Published online December 1, 2005; 10.1124/jpet.105.096255 [Abstract] [Full Text] [PDF]  

Sheng-Xue Xie, Prasanta Ghorai, Qi-Zhuang Ye, Armin Buschauer, and Roland Seifert

Probing Ligand-Specific Histamine H₁- and H₂-Receptor Conformations with N^G-Acylated Imidazolylpropylguanidines
J Pharmacol Exp Ther 2006 317: 139-146. Published online January 4, 2006; 10.1124/jpet.105.097923 [Abstract] [Full Text] [PDF]  

Neil P. Davies, Yohan Suryo Rahmanto, Christopher R. Chitambar, and Des R. Richardson

Resistance to the Antineoplastic Agent Gallium Nitrate Results in Marked Alterations in Intracellular Iron and Gallium Trafficking: Identification of Novel Intermediates
J Pharmacol Exp Ther 2006 317: 153-162. Published online December 22, 2005; 10.1124/jpet.105.099044 [Abstract] [Full Text] [PDF]  

Weili Yan and Hsin-Hsiung Tai

Glycogen Synthase Kinase-3 Phosphorylation, T-Cell Factor Signaling Activation, and Cell Morphology Change following Stimulation of Thromboxane Receptor
J Pharmacol Exp Ther 2006 317: 267-274. Published online December 13, 2005; 10.1124/jpet.105.096826 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Meng Guo, Richard J. Roman, Joseph D. Fenstermacher, Stephen L. Brown, John R. Falck, Ali S. Arbab, Paul A. Edwards, and A. Guillermo Scicli

9L Gliosarcoma Cell Proliferation and Tumor Growth in Rats Are Suppressed by N-Hydroxy-N'-(4-butyl-2-methylphenol) Formamidine (HET0016), a Selective Inhibitor of CYP4A
J Pharmacol Exp Ther 2006 317: 97-108. Published online December 13, 2005; 10.1124/jpet.105.097782 [Abstract] [Full Text] [PDF]  

B. Gava, S. Zorzet, P. Spessotto, M. Cocchietto, and G. Sava

Inhibition of B16 Melanoma Metastases with the Ruthenium Complex Imidazolium trans-Imidazoledimethylsulfoxide-tetrachlororuthenate and Down-Regulation of Tumor Cell Invasion
J Pharmacol Exp Ther 2006 317: 284-291. Published online December 20, 2005; 10.1124/jpet.105.095141 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Jun Yang, Casey E. Bohl, Vipin A. Nair, Suni M. Mustafa, Seoung Soo Hong, Duane D. Miller, and James T. Dalton

Preclinical Pharmacology of a Nonsteroidal Ligand for Androgen Receptor-Mediated Imaging of Prostate Cancer
J Pharmacol Exp Ther 2006 317: 402-408. Published online January 24, 2006; 10.1124/jpet.105.094334 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Asok R. Karuri, Yong Huang, Sridevi Bodreddigari, Carrie Hayes Sutter, Bill D. Roebuck, Thomas W. Kensler, and Thomas R. Sutter

3H-1,2-Dithiole-3-thione Targets Nuclear Factor B to Block Expression of Inducible Nitric-Oxide Synthase, Prevents Hypotension, and Improves Survival in Endotoxemic Rats
J Pharmacol Exp Ther 2006 317: 61-67. Published online December 21, 2005; 10.1124/jpet.105.096396 [Abstract] [Full Text] [PDF]  

Hideo Utsumi, Keiji Yasukawa, Tetsuhiro Soeda, Ken-ichi Yamada, Ryota Shigemi, Takashi Yao, and Masazumi Tsuneyoshi

Noninvasive Mapping of Reactive Oxygen Species by in Vivo Electron Spin Resonance Spectroscopy in Indomethacin-Induced Gastric Ulcers in Rats
J Pharmacol Exp Ther 2006 317: 228-235. Published online December 9, 2005; 10.1124/jpet.105.095166 [Abstract] [Full Text] [PDF]  

Nancy M. Walker, Janet E. Simpson, Roy C. Levitt, Kathryn T. Boyle, and Lane L. Clarke

Talniflumate Increases Survival in a Cystic Fibrosis Mouse Model of Distal Intestinal Obstructive Syndrome
J Pharmacol Exp Ther 2006 317: 275-283. Published online December 14, 2005; 10.1124/jpet.105.094847 [Abstract] [Full Text] [PDF]  

Ruitang Deng, Dongfang Yang, Jian Yang, and Bingfang Yan

Oxysterol 22(R)-Hydroxycholesterol Induces the Expression of the Bile Salt Export Pump through Nuclear Receptor Farsenoid X Receptor but Not Liver X Receptor
J Pharmacol Exp Ther 2006 317: 317-325. Published online December 21, 2005; 10.1124/jpet.105.097758 [Abstract] [Full Text] [PDF]  

Christina Ziemann, Armin Riecke, Gudrun Rüdell, Elke Oetjen, Hans J. Steinfelder, Christian Lass, Georg F. Kahl, and Karen I. Hirsch-Ernst

The Role of Prostaglandin E Receptor-Dependent Signaling via cAMP in Mdr1b Gene Activation in Primary Rat Hepatocyte Cultures
J Pharmacol Exp Ther 2006 317: 378-386. Published online January 13, 2006; 10.1124/jpet.105.094193 [Abstract] [Full Text] [PDF] [Data Supplement]   

Florentine Nieuwmeyer, Jing Ye, and Jan D. Huizinga

Ava[L-Pro⁹,N-MeLeu10] Substance P(7-11) (GR 73632) and Sar⁹, Met(O₂)¹¹ Increase Distention-Induced Peristalsis through Activation of Neurokinin-1 Receptors on Smooth Muscle and Interstitial Cells of Cajal
J Pharmacol Exp Ther 2006 317: 439-445. Published online December 5, 2005; 10.1124/jpet.105.094920 [Abstract] [Full Text] [PDF]  

Zbigniew K. Krowicki and Daniel R. Kapusta

Tonic Nociceptinergic Inputs to Neurons in the Hypothalamic Paraventricular Nucleus Contribute to Sympathetic Vasomotor Tone and Water and Electrolyte Homeostasis in Conscious Rats
J Pharmacol Exp Ther 2006 317: 446-453. Published online January 11, 2006; 10.1124/jpet.105.094441 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Hao-Liang Xu, Luisa Salter-Cid, Matthew D. Linnik, Eric Y. Wang, Chanannait Paisansathan, and Dale A. Pelligrino

Vascular Adhesion Protein-1 Plays an Important Role in Postischemic Inflammation and Neuropathology in Diabetic, Estrogen-Treated Ovariectomized Female Rats Subjected to Transient Forebrain Ischemia
J Pharmacol Exp Ther 2006 317: 19-29. Published online December 8, 2005; 10.1124/jpet.105.096958 [Abstract] [Full Text] [PDF]  

Xiaohua Xue, Kuei-Tai A. Lai, Jing-Feng Huang, Yin Gu, Lars Karlsson, and Anne Fourie

Anti-Inflammatory Activity in Vitro and in Vivo of the Protein Farnesyltransferase Inhibitor Tipifarnib
J Pharmacol Exp Ther 2006 317: 53-60. Published online December 13, 2005; 10.1124/jpet.105.095976 [Abstract] [Full Text] [PDF]  

Laura M. Kreckler, Tina C. Wan, Zhi-Dong Ge, and John A. Auchampach

Adenosine Inhibits Tumor Necrosis Factor- Release from Mouse Peritoneal Macrophages via A_2A and A_2B but Not the A₃ Adenosine Receptor
J Pharmacol Exp Ther 2006 317: 172-180. Published online December 9, 2005; 10.1124/jpet.105.096016 [Abstract] [Full Text] [PDF]  

Martin D. Lehner, Degenhard Marx, Rainer Boer, Andreas Strub, Christian Hesslinger, Manfrid Eltze, Wolf-Rüdiger Ulrich, Frank Schwoebel, Ralph Theo Schermuly, and Johannes Barsig

In Vivo Characterization of the Novel Imidazopyridine BYK191023 [2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a Potent and Highly Selective Inhibitor of Inducible Nitric-Oxide Synthase
J Pharmacol Exp Ther 2006 317: 181-187. Published online December 20, 2005; 10.1124/jpet.105.098673 [Abstract] [Full Text] [PDF]  

Tatsuaki Morokata, Keiko Suzuki, Yohei Masunaga, Katsunari Taguchi, Koichiro Morihira, Ippei Sato, Masahiro Fujii, Satoko Takizawa, Yuichi Torii, Naoyoshi Yamamoto, Masayuki Kaneko, Toshimitsu Yamada, Koichiro Takahashi, and Yasuaki Shimizu

A Novel, Selective, and Orally Available Antagonist for CC Chemokine Receptor 3
J Pharmacol Exp Ther 2006 317: 244-250. Published online December 9, 2005; 10.1124/jpet.105.097048 [Abstract] [Full Text] [PDF]  

Lajos Gera, Jean-Philippe Fortin, Albert Adam, John M. Stewart, and François Marceau

Discovery of a Dual-Function Peptide That Combines Aminopeptidase N Inhibition and Kinin B₁ Receptor Antagonism
J Pharmacol Exp Ther 2006 317: 300-308. Published online December 20, 2005; 10.1124/jpet.105.095661 [Abstract] [Full Text] [PDF]  

Moul Dey, David Ribnicky, Anvar G. Kurmukov, and Ilya Raskin

In Vitro and in Vivo Anti-Inflammatory Activity of a Seed Preparation Containing Phenethylisothiocyanate
J Pharmacol Exp Ther 2006 317: 326-333. Published online December 22, 2005; 10.1124/jpet.105.096511 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Christina Unger, Marie M. Svedberg, Wen-Feng Yu, Monika M. Hedberg, and Agneta Nordberg

Effect of Subchronic Treatment of Memantine, Galantamine, and Nicotine in the Brain of Tg2576 (APPswe) Transgenic Mice
J Pharmacol Exp Ther 2006 317: 30-36. Published online December 14, 2005; 10.1124/jpet.105.098566 [Abstract] [Full Text] [PDF]  

Melissa A. Mahgoub, Yildirim Sara, Ege T. Kavalali, and Lisa M. Monteggia

Reciprocal Interaction of Serotonin and Neuronal Activity in Regulation of cAMP-Responsive Element-Dependent Gene Expression
J Pharmacol Exp Ther 2006 317: 88-96. Published online December 28, 2005; 10.1124/jpet.105.097097 [Abstract] [Full Text] [PDF]  

Ling Wei, Byung H. Han, Ying Li, Christine L. Keogh, David M. Holtzman, and Shan Ping Yu

Cell Death Mechanism and Protective Effect of Erythropoietin after Focal Ischemia in the Whisker-Barrel Cortex of Neonatal Rats
J Pharmacol Exp Ther 2006 317: 109-116. Published online December 15, 2005; 10.1124/jpet.105.094391 [Abstract] [Full Text] [PDF]  

Sylvie Chalon, Hakan Hall, Wadad Saba, Lucette Garreau, Frédéric Dollé, Christer Halldin, Patrick Emond, Michel Bottlaender, Jean-Bernard Deloye, Julie Helfenbein, Jean-Claude Madelmont, Sylvie Bodard, Zoïa Mincheva, Jean-Claude Besnard, and Denis Guilloteau

Pharmacological Characterization of (E)-N-(4-Fluorobut-2-enyl)-2-carbomethoxy-3-(4'-tolyl)nortropane (LBT-999) as a Highly Promising Fluorinated Ligand for the Dopamine Transporter
J Pharmacol Exp Ther 2006 317: 147-152. Published online December 9, 2005; 10.1124/jpet.105.096792 [Abstract] [Full Text] [PDF]  

René Bernard, Ralph Lydic, and Helen A. Baghdoyan

Hypocretin (Orexin) Receptor Subtypes Differentially Enhance Acetylcholine Release and Activate G Protein Subtypes in Rat Pontine Reticular Formation
J Pharmacol Exp Ther 2006 317: 163-171. Published online December 13, 2005; 10.1124/jpet.105.097071 [Abstract] [Full Text] [PDF]  

Yan Zhou, Bejamin S. Bunney, and Wei-Xing Shi

Differential Effects of Cocaine on Firing Rate and Pattern of Dopamine Neurons: Role of ₁ Receptors and Comparison with L-Dopa and Apomorphine
J Pharmacol Exp Ther 2006 317: 196-201. Published online December 5, 2005; 10.1124/jpet.105.094045 [Abstract] [Full Text] [PDF]  

Sandra A. G. Visser, Björn Sällström, Tomas Forsberg, Lambertus A. Peletier, and Johan Gabrielsson

Modeling Drug- and System-Related Changes in Body Temperature: Application to Clomethiazole-Induced Hypothermia, Long-Lasting Tolerance Development, and Circadian Rhythm in Rats
J Pharmacol Exp Ther 2006 317: 209-219. Published online December 8, 2005; 10.1124/jpet.105.095224 [Abstract] [Full Text] [PDF]  

Stephen A. Varvel, Benjamin F. Cravatt, April E. Engram, and Aron H. Lichtman

Fatty Acid Amide Hydrolase (–/–) Mice Exhibit an Increased Sensitivity to the Disruptive Effects of Anandamide or Oleamide in a Working Memory Water Maze Task
J Pharmacol Exp Ther 2006 317: 251-257. Published online December 13, 2005; 10.1124/jpet.105.095059 [Abstract] [Full Text] [PDF]  

Saman Rezazadeh, Thomas W. Claydon, and David Fedida

KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor, Is a Direct Extracellular Blocker of Voltage-Gated Potassium Channels
J Pharmacol Exp Ther 2006 317: 292-299. Published online December 20, 2005; 10.1124/jpet.105.097618 [Abstract] [Full Text] [PDF]  

Hirokazu Mizoguchi, Hiroyuki Watanabe, Takafumi Hayashi, Wataru Sakurada, Toshiki Sawai, Tsutomu Fujimura, Tsukasa Sakurada, and Shinobu Sakurada

Possible Involvement of Dynorphin A-(1–17) Release via µ₁-Opioid Receptors in Spinal Antinociception by Endomorphin-2
J Pharmacol Exp Ther 2006 317: 362-368. Published online January 4, 2006; 10.1124/jpet.105.098293 [Abstract] [Full Text] [PDF]  

Robert E. Petroski, Jordan E. Pomeroy, Ronnie Das, Heath Bowman, Weidong Yang, Adele P. Chen, and Alan C. Foster

Indiplon Is a High-Affinity Positive Allosteric Modulator with Selectivity for 1 Subunit-Containing GABA_A Receptors
J Pharmacol Exp Ther 2006 317: 369-377. Published online January 6, 2006; 10.1124/jpet.105.096701 [Abstract] [Full Text] [PDF]  

Douglas C. Jones and Michael J. Kuhar

Cocaine-Amphetamine-Regulated Transcript Expression in the Rat Nucleus Accumbens Is Regulated by Adenylyl Cyclase and the Cyclic Adenosine 5'-Monophosphate/Protein Kinase A Second Messenger System
J Pharmacol Exp Ther 2006 317: 454-461. Published online December 1, 2005; 10.1124/jpet.105.096123 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Xiaodong Wang and Arthur I. Cederbaum

S-Adenosyl-L-methionine Attenuates Hepatotoxicity Induced by Agonistic Jo2 Fas Antibody following CYP2E1 Induction in Mice
J Pharmacol Exp Ther 2006 317: 44-52. Published online December 22, 2005; 10.1124/jpet.105.098004 [Abstract] [Full Text] [PDF]  

James F. Dillman, III, Alison I. Hege, Christopher S. Phillips, Linda D. Orzolek, Albert J. Sylvester, Carol Bossone, Claudia Henemyre-Harris, Robyn C. Kiser, Young W. Choi, John J. Schlager, and Carol L. Sabourin

Microarray Analysis of Mouse Ear Tissue Exposed to Bis-(2-chloroethyl) Sulfide: Gene Expression Profiles Correlate with Treatment Efficacy and An Established Clinical Endpoint
J Pharmacol Exp Ther 2006 317: 76-87. Published online December 23, 2005; 10.1124/jpet.105.097014 [Abstract] [Full Text] [PDF] [Data Supplement]   

Yun-Sik Lee, Jie Wan, Bong-Jo Kim, Myung-Ae Bae, and Byoung J. Song

Ubiquitin-Dependent Degradation of p53 Protein Despite Phosphorylation at Its N Terminus by Acetaminophen
J Pharmacol Exp Ther 2006 317: 202-208. Published online December 5, 2005; 10.1124/jpet.105.096719 [Abstract] [Full Text] [PDF] [Data Supplement]   

Bohumila Tarabová, Martina Kurejová, Zdena Sulová, Melinda Drabová, and L'ubica Lacinová

Inorganic Mercury and Methylmercury Inhibit the Ca_v3.1 Channel Expressed in Human Embryonic Kidney 293 Cells by Different Mechanisms
J Pharmacol Exp Ther 2006 317: 418-427. Published online December 2, 2005; 10.1124/jpet.105.095463 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "The Chemoprotective Agent N-Acetylcysteine Blocks Cisplatin-Induced Apoptosis through Caspase Signaling Pathway"
J Pharmacol Exp Ther 2006 317: 463. [Full Text] [PDF]  

EDITOR'S NOTE:

Rick G. Schnellmann

Editor's Note Regarding "Protective Mechanisms of a Metalloporhyrinic Peroxynitrite Decomposition Catalyst, WW85, in Rat Cardiac Transplants"
J Pharmacol Exp Ther 2006 317: 462. [Full Text] [PDF]  

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