PERSPECTIVES IN PHARMACOLOGY:

Maryka Quik and J. Michael McIntosh

Striatal 6^* Nicotinic Acetylcholine Receptors: Potential Targets for Parkinson's Disease Therapy
J Pharmacol Exp Ther 2006 316: 481-489. Published online October 6, 2005; 10.1124/jpet.105.094375 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Christopher P. Landowski, Philip L. Lorenzi, Xueqin Song, and Gordon L. Amidon

Nucleoside Ester Prodrug Substrate Specificity of Liver Carboxylesterase
J Pharmacol Exp Ther 2006 316: 572-580. Published online October 13, 2005; 10.1124/jpet.105.092726 [Abstract] [Full Text] [PDF]  

Young-Joo Lee, Jun Maeda, Hiroyuki Kusuhara, Takashi Okauchi, Motoki Inaji, Yuji Nagai, Shigeru Obayashi, Ryuji Nakao, Kazutoshi Suzuki, Yuichi Sugiyama, and Tetsuya Suhara

In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using [¹¹C]Verapamil
J Pharmacol Exp Ther 2006 316: 647-653. Published online November 17, 2005; 10.1124/jpet.105.088328 [Abstract] [Full Text] [PDF]  

Yvonne Y. Lau, Hideaki Okochi, Yong Huang, and Leslie Z. Benet

Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ Systems
J Pharmacol Exp Ther 2006 316: 762-771. Published online October 28, 2005; 10.1124/jpet.105.093088 [Abstract] [Full Text] [PDF]  

Wolfgang E. Thasler, Rania Dayoub, Marcus Mühlbauer, Claus Hellerbrand, Thomas Singer, Anja Gräbe, Karl-Walter Jauch, Hans-Jürgen Schlitt, and Thomas S. Weiss

Repression of Cytochrome P450 Activity in Human Hepatocytes in Vitro by a Novel Hepatotrophic Factor, Augmenter of Liver Regeneration
J Pharmacol Exp Ther 2006 316: 822-829. Published online October 7, 2005; 10.1124/jpet.105.094201 [Abstract] [Full Text] [PDF] [Data Supplement]   

Natalie L. Trevaskis, Christopher J. H. Porter, and William N. Charman

The Lymph Lipid Precursor Pool Is a Key Determinant of Intestinal Lymphatic Drug Transport
J Pharmacol Exp Ther 2006 316: 881-891. Published online October 25, 2005; 10.1124/jpet.105.094094 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

M. C. Holden Ko, Mary F. Divin, Heeseung Lee, James H. Woods, and John R. Traynor

Differential in Vivo Potencies of Naltrexone and 6-Naltrexol in the Monkey
J Pharmacol Exp Ther 2006 316: 772-779. Published online October 28, 2005; 10.1124/jpet.105.094409 [Abstract] [Full Text] [PDF]  

Flavia Carla Meotti, Ana Paula Luiz, Moacir Geraldo Pizzolatti, Cândida A. L. Kassuya, João B. Calixto, and Adair R. S. Santos

Analysis of the Antinociceptive Effect of the Flavonoid Myricitrin: Evidence for a Role of the L-Arginine-Nitric Oxide and Protein Kinase C Pathways
J Pharmacol Exp Ther 2006 316: 789-796. Published online October 31, 2005; 10.1124/jpet.105.092825 [Abstract] [Full Text] [PDF]  

Francis C. Colpaert, Kristof Deseure, Luis Stinus, and Hugo Adriaensen

High-Efficacy 5-Hydroxytryptamine 1A Receptor Activation Counteracts Opioid Hyperallodynia and Affective Conditioning
J Pharmacol Exp Ther 2006 316: 892-899. Published online October 27, 2005; 10.1124/jpet.105.095109 [Abstract] [Full Text] [PDF]  

Miao-Kun Sun and Daniel L. Alkon

Differential Gender-Related Vulnerability to Depression Induction and Converging Antidepressant Responses in Rats
J Pharmacol Exp Ther 2006 316: 926-932. Published online October 14, 2005; 10.1124/jpet.105.093948 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Yukako Hatanaka, Narumi Hobara, Jin Honghua, Shinji Akiyama, Hideki Nawa, Yuta Kobayashi, Fusako Takayama, Yutaka Gomita, and Hiromu Kawasaki

Neuronal Nitric-Oxide Synthase Inhibition Facilitates Adrenergic Neurotransmission in Rat Mesenteric Resistance Arteries
J Pharmacol Exp Ther 2006 316: 490-497. Published online October 19, 2005; 10.1124/jpet.105.094656 [Abstract] [Full Text] [PDF]  

Anthony A. Fossa, Todd Wisialowski, and Kimberly Crimin

QT Prolongation Modifies Dynamic Restitution and Hysteresis of the Beat-to-Beat QT-TQ Interval Relationship during Normal Sinus Rhythm under Varying States of Repolarization
J Pharmacol Exp Ther 2006 316: 498-506. Published online October 4, 2005; 10.1124/jpet.105.095471 [Abstract] [Full Text] [PDF] [Data Supplement]   

Béatrice Hechler, Christelle Nonne, Eun Joo Roh, Marco Cattaneo, Jean-Pierre Cazenave, François Lanza, Kenneth A. Jacobson, and Christian Gachet

MRS2500 [2-Iodo-N⁶-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a Potent, Selective, and Stable Antagonist of the Platelet P2Y₁ Receptor with Strong Antithrombotic Activity in Mice
J Pharmacol Exp Ther 2006 316: 556-563. Published online October 19, 2005; 10.1124/jpet.105.094037 [Abstract] [Full Text] [PDF]  

Marnie L. Olson, Margaret E. Kargacin, Thomas W. Honeyman, Christopher A. Ward, and Gary J. Kargacin

Effects of Phytoestrogens on Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2a and Ca²⁺ Uptake into Cardiac Sarcoplasmic Reticulum
J Pharmacol Exp Ther 2006 316: 628-635. Published online October 14, 2005; 10.1124/jpet.105.092940 [Abstract] [Full Text] [PDF]  

Cleber E. Teixeira, Fernanda B. M. Priviero, and R. Clinton Webb

Differential Effects of the Phosphodiesterase Type 5 Inhibitors Sildenafil, Vardenafil, and Tadalafil in Rat Aorta
J Pharmacol Exp Ther 2006 316: 654-661. Published online October 4, 2005; 10.1124/jpet.105.092544 [Abstract] [Full Text] [PDF]  

Jin-Song Bian, Qian Chen Yong, Ting-Ting Pan, Zhan-Ning Feng, Muhammed Yusuf Ali, Shufeng Zhou, and Philip Keith Moore

Role of Hydrogen Sulfide in the Cardioprotection Caused by Ischemic Preconditioning in the Rat Heart and Cardiac Myocytes
J Pharmacol Exp Ther 2006 316: 670-678. Published online October 4, 2005; 10.1124/jpet.105.092023 [Abstract] [Full Text] [PDF]  

Arvinder K. Dhalla, Mei-Yee Wong, Wei-Qun Wang, Italo Biaggioni, and Luiz Belardinelli

Tachycardia Caused by A_2A Adenosine Receptor Agonists Is Mediated by Direct Sympathoexcitation in Awake Rats
J Pharmacol Exp Ther 2006 316: 695-702. Published online October 14, 2005; 10.1124/jpet.105.095323 [Abstract] [Full Text] [PDF]  

Roberta d'Emmanuele di Villa Bianca, Raffaella Sorrentino, Rosalinda Sorrentino, Ciro Imbimbo, Alessandro Palmieri, Ferdinando Fusco, Mario Maggi, Raffaele De Palma, Giuseppe Cirino, and Vincenzo Mirone

Sphingosine 1-Phosphate Induces Endothelial Nitric-Oxide Synthase Activation through Phosphorylation in Human Corpus Cavernosum
J Pharmacol Exp Ther 2006 316: 703-708. Published online October 18, 2005; 10.1124/jpet.105.093419 [Abstract] [Full Text] [PDF]  

Lin Wu, John C. Shryock, Yejia Song, and Luiz Belardinelli

An Increase in Late Sodium Current Potentiates the Proarrhythmic Activities of Low-Risk QT-Prolonging Drugs in Female Rabbit Hearts
J Pharmacol Exp Ther 2006 316: 718-726. Published online October 18, 2005; 10.1124/jpet.105.094862 [Abstract] [Full Text] [PDF]  

Christopher P. Regan, Audrey A. Wallace, Hillary K. Cresswell, Charity L. Atkins, and Joseph J. Lynch, Jr.

In Vivo Cardiac Electrophysiologic Effects of a Novel Diphenylphosphine Oxide I_Kur Blocker, (2-Isopropyl-5-methylcyclohexyl) Diphenylphosphine Oxide, in Rat and Nonhuman Primate
J Pharmacol Exp Ther 2006 316: 727-732. Published online October 21, 2005; 10.1124/jpet.105.094839 [Abstract] [Full Text] [PDF]  

Benjamin B. Davis, Christophe Morisseau, John W. Newman, Theresa L. Pedersen, Bruce D. Hammock, and Robert H. Weiss

Attenuation of Vascular Smooth Muscle Cell Proliferation by 1-Cyclohexyl-3-dodecyl Urea Is Independent of Soluble Epoxide Hydrolase Inhibition
J Pharmacol Exp Ther 2006 316: 815-821. Published online October 12, 2005; 10.1124/jpet.105.091876 [Abstract] [Full Text] [PDF]  

Sheila M. Gardiner, Julie E. March, Philip A. Kemp, and Terence Bennett

Mesenteric Vasoconstriction and Hindquarters Vasodilatation Accompany the Pressor Actions of Exendin-4 in Conscious Rats
J Pharmacol Exp Ther 2006 316: 852-859. Published online October 12, 2005; 10.1124/jpet.105.093104 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Rosemarie Macion-Dazard, Nicholas Callahan, Zhen Xu, Nan Wu, Marc Thibonnier, and Menachem Shoham

Mapping the Binding Site of Six Nonpeptide Antagonists to the Human V₂-Renal Vasopressin Receptor
J Pharmacol Exp Ther 2006 316: 564-571. Published online October 18, 2005; 10.1124/jpet.105.095554 [Abstract] [Full Text] [PDF]  

Christiane Quiniou, Florian Sennlaub, Martin H. Beauchamp, Daniella Checchin, Isabelle Lahaie, Sonia Brault, Fernand Gobeil, Jr., Mirna Sirinyan, Amna Kooli, Pierre Hardy, Alexey Pshezhetsky, and Sylvain Chemtob

Dominant Role for Calpain in Thromboxane-Induced Neuromicrovascular Endothelial Cytotoxicity
J Pharmacol Exp Ther 2006 316: 618-627. Published online October 7, 2005; 10.1124/jpet.105.093898 [Abstract] [Full Text] [PDF]  

Georg T. Wondrak, Myron K. Jacobson, and Elaine L. Jacobson

Antimelanoma Activity of Apoptogenic Carbonyl Scavengers
J Pharmacol Exp Ther 2006 316: 805-814. Published online October 6, 2005; 10.1124/jpet.105.094953 [Abstract] [Full Text] [PDF]  

Ingrid Beck-Speier, Niru Dayal, Erwin Karg, Konrad L. Maier, Gabriele Schumann, Manuela Semmler, and Stephan M. Koelsch

Oxymetazoline Inhibits Proinflammatory Reactions: Effect on Arachidonic Acid-Derived Metabolites
J Pharmacol Exp Ther 2006 316: 843-851. Published online October 12, 2005; 10.1124/jpet.105.093278 [Abstract] [Full Text] [PDF]  

S. L. Cockerill and J. S. Mitcheson

Direct Block of Human Ether-a-go-go-Related Gene Potassium Channels by Caffeine
J Pharmacol Exp Ther 2006 316: 860-868. Published online October 14, 2005; 10.1124/jpet.105.094755 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Ching-Chuan Kuo, Jin-Fen Liu, and Jang-Yang Chang

DNA Repair Enzyme, O⁶-Methylguanine DNA Methyltransferase, Modulates Cytotoxicity of Camptothecin-Derived Topoisomerase I Inhibitors
J Pharmacol Exp Ther 2006 316: 946-954. Published online October 28, 2005; 10.1124/jpet.105.095919 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Michael Loffler, Martin Bilban, Mark Reimers, Werner Waldhäusl, and Thomas M. Stulnig

Blood Glucose-Lowering Nuclear Receptor Agonists Only Partially Normalize Hepatic Gene Expression in db/db Mice
J Pharmacol Exp Ther 2006 316: 797-804. Published online October 31, 2005; 10.1124/jpet.105.093831 [Abstract] [Full Text] [PDF] [Data Supplement]   

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Xiaosun Zhou and Curtis K. Kost, Jr.

Adenosine A1 Receptor Antagonist Blunts Urinary Potassium Excretion, but Not Renal Hemodynamic Effects, Induced by Carbonic Anhydrase Inhibitor in Rats
J Pharmacol Exp Ther 2006 316: 530-538. Published online November 8, 2005; 10.1124/jpet.105.091462 [Abstract] [Full Text] [PDF]  

Tohru Kotani, Atsushi Kobata, Eiji Nakamura, Kikuko Amagase, and Koji Takeuchi

Roles of Cyclooxygenase-2 and Prostacyclin/IP Receptors in Mucosal Defense against Ischemia/Reperfusion Injury in Mouse Stomach
J Pharmacol Exp Ther 2006 316: 547-555. Published online October 19, 2005; 10.1124/jpet.105.093195 [Abstract] [Full Text] [PDF]  

Ina Bergheim, Luping Guo, Molly Anne Davis, Ilinca Duveau, and Gavin E. Arteel

Critical Role of Plasminogen Activator Inhibitor-1 in Cholestatic Liver Injury and Fibrosis
J Pharmacol Exp Ther 2006 316: 592-600. Published online October 12, 2005; 10.1124/jpet.105.095042 [Abstract] [Full Text] [PDF]  

Pascale Anderle, Carsten Uhd Nielsen, Julia Pinsonneault, Pernille Lindskov Krog, Birger Brodin, and Wolfgang Sadée

Genetic Variants of the Human Dipeptide Transporter PEPT1
J Pharmacol Exp Ther 2006 316: 636-646. Published online October 28, 2005; 10.1124/jpet.105.094615 [Abstract] [Full Text] [PDF]  

Rong-Jyh Lin, Bin-Nan Wu, Yi-Ching Lo, Li-Mei An, Zen-Kong Dai, Young-Tso Lin, Chao-Shun Tang, and Ing-Jun Chen

A Xanthine-Based Epithelium-Dependent Airway Relaxant KMUP-3 (7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) Increases Respiratory Performance and Protects against Tumor Necrosis Factor--Induced Tracheal Contraction, Involving Nitric Oxide Release and Expression of cGMP and Protein Kinase G
J Pharmacol Exp Ther 2006 316: 709-717. Published online October 18, 2005; 10.1124/jpet.105.092171 [Abstract] [Full Text] [PDF]  

Carlotta E. Groves, Wendy B. Suhre, Nathan J. Cherrington, and Stephen H. Wright

Sex Differences in the mRNA, Protein, and Functional Expression of Organic Anion Transporter (Oat) 1, Oat3, and Organic Cation Transporter (Oct) 2 in Rabbit Renal Proximal Tubules
J Pharmacol Exp Ther 2006 316: 743-752. Published online October 25, 2005; 10.1124/jpet.105.094979 [Abstract] [Full Text] [PDF]  

Cemil Göçmen, H. Sinem Büyüknacar, Alexander Ya Kots, Ferid Murad, Olcay Kiroglu, and Eda Karabal Kumcu

The Relaxant Activity of 4,7-Dimethyl-1,2,5-oxadiazolo[3,4-d]-pyridazine 1,5,6-Trioxide in the Mouse Corpus Cavernosum
J Pharmacol Exp Ther 2006 316: 753-761. Published online October 27, 2005; 10.1124/jpet.105.094250 [Abstract] [Full Text] [PDF]  

Alan S. Braverman, Amit S. Tibb, and Michael R. Ruggieri, Sr

M₂ and M₃ Muscarinic Receptor Activation of Urinary Bladder Contractile Signal Transduction. I. Normal Rat Bladder
J Pharmacol Exp Ther 2006 316: 869-874. Published online October 21, 2005; 10.1124/jpet.105.097303 [Abstract] [Full Text] [PDF]  

Alan S. Braverman, Leo R. Doumanian, and Michael R. Ruggieri, Sr

M₂ and M₃ Muscarinic Receptor Activation of Urinary Bladder Contractile Signal Transduction. II. Denervated Rat Bladder
J Pharmacol Exp Ther 2006 316: 875-880. Published online October 21, 2005; 10.1124/jpet.105.094961 [Abstract] [Full Text] [PDF]  

S. Videla, J. Vilaseca, C. Medina, M. Mourelle, F. Guarner, A. Salas, and J.-R. Malagelada

Selective Inhibition of Phosphodiesterase-4 Ameliorates Chronic Colitis and Prevents Intestinal Fibrosis
J Pharmacol Exp Ther 2006 316: 940-945. Published online October 27, 2005; 10.1124/jpet.105.090837 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Isabella Dell'Aica, Luigi Sartor, Paola Galletti, Daria Giacomini, Arianna Quintavalla, Fiorella Calabrese, Cinzia Giacometti, Enrico Brunetta, Francesco Piazza, Carlo Agostini, and Spiridione Garbisa

Inhibition of Leukocyte Elastase, Polymorphonuclear Chemoinvasion, and Inflammation-Triggered Pulmonary Fibrosis by a 4-Alkyliden--lactam with a Galloyl Moiety
J Pharmacol Exp Ther 2006 316: 539-546. Published online October 25, 2005; 10.1124/jpet.105.096248 [Abstract] [Full Text] [PDF]  

Yi-Na Zhu, Wei-Min Zhao, Yi-Fu Yang, Qun-Fang Liu, Yu Zhou, Jia Tian, Jia Ni, Yun-Feng Fu, Xiang-Gen Zhong, Wei Tang, Ru Zhou, Pei-Lan He, Xiao-Yu Li, and Jian-Ping Zuo

Periplocoside E, an Effective Compound from Periploca sepium Bge, Inhibited T Cell Activation in Vitro and in Vivo
J Pharmacol Exp Ther 2006 316: 662-669. Published online October 4, 2005; 10.1124/jpet.105.093732 [Abstract] [Full Text] [PDF] [Data Supplement]   

Charles A. Lunn, Jay S. Fine, Alberto Rojas-Triana, James V. Jackson, Xuedong Fan, Ted T. Kung, Waldemar Gonsiorek, Martin A. Schwarz, Brian Lavey, Joseph A. Kozlowski, Satwant K. Narula, Daniel J. Lundell, R. William Hipkin, and Loretta A. Bober

A Novel Cannabinoid Peripheral Cannabinoid Receptor-Selective Inverse Agonist Blocks Leukocyte Recruitment in Vivo
J Pharmacol Exp Ther 2006 316: 780-788. Published online October 28, 2005; 10.1124/jpet.105.093500 [Abstract] [Full Text] [PDF]  

Nahid A. Shahabi, Kathy McAllen, and Burt M. Sharp

Opioid Receptors Stimulate Akt-Dependent Phosphorylation of c-jun in T Cells
J Pharmacol Exp Ther 2006 316: 933-939. Published online October 25, 2005; 10.1124/jpet.105.091447 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Nather Madjid, Elin Elvander Tottie, Maria Lüttgen, Björn Meister, Johan Sandin, Alexander Kuzmin, Oliver Stiedl, and Sven Ove Ögren

5-Hydroxytryptamine 1A Receptor Blockade Facilitates Aversive Learning in Mice: Interactions with Cholinergic and Glutamatergic Mechanisms
J Pharmacol Exp Ther 2006 316: 581-591. Published online October 13, 2005; 10.1124/jpet.105.092262 [Abstract] [Full Text] [PDF]  

Yasuhiko Kawasaki, Tatsuro Kohno, and Ru-Rong Ji

Different Effects of Opioid and Cannabinoid Receptor Agonists on C-Fiber-Induced Extracellular Signal-Regulated Kinase Activation in Dorsal Horn Neurons in Normal and Spinal Nerve-Ligated Rats
J Pharmacol Exp Ther 2006 316: 601-607. Published online October 12, 2005; 10.1124/jpet.105.093583 [Abstract] [Full Text] [PDF]  

Birgit Engler, Ilka Freiman, Michal Urbanski, and Bela Szabo

Effects of Exogenous and Endogenous Cannabinoids on GABAergic Neurotransmission between the Caudate-Putamen and the Globus Pallidus in the Mouse
J Pharmacol Exp Ther 2006 316: 608-617. Published online October 7, 2005; 10.1124/jpet.105.092718 [Abstract] [Full Text] [PDF]  

C. M. Hernandez, D. A. Gearhart, V. Parikh, E. J. Hohnadel, L. W. Davis, M. L. Middlemore, S. P. Warsi, J. L. Waller, and A. V. Terry, Jr

Comparison of Galantamine and Donepezil for Effects on Nerve Growth Factor, Cholinergic Markers, and Memory Performance in Aged Rats
J Pharmacol Exp Ther 2006 316: 679-694. Published online October 7, 2005; 10.1124/jpet.105.093047 [Abstract] [Full Text] [PDF]  

Qian Chen, De-Pei Li, and Hui-Lin Pan

Presynaptic ₁ Adrenergic Receptors Differentially Regulate Synaptic Glutamate and GABA Release to Hypothalamic Presympathetic Neurons
J Pharmacol Exp Ther 2006 316: 733-742. Published online October 25, 2005; 10.1124/jpet.105.094797 [Abstract] [Full Text] [PDF]  

Pierre Clément, Jacques Bernabé, Hosein Kami Kia, Laurent Alexandre, and François Giuliano

D2-Like Receptors Mediate the Expulsion Phase of Ejaculation Elicited by 8-Hydroxy-2-(di-N-propylamino)tetralin in Rats
J Pharmacol Exp Ther 2006 316: 830-834. Published online October 12, 2005; 10.1124/jpet.105.092411 [Abstract] [Full Text] [PDF]  

Elaine A. Gay, Rebecca C. Klein, and Jerrel L. Yakel

Apolipoprotein E-Derived Peptides Block 7 Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 2006 316: 835-842. Published online October 25, 2005; 10.1124/jpet.105.095505 [Abstract] [Full Text] [PDF] [Data Supplement]   

Verónica González-Núñez, Alejandro Barrallo, John R. Traynor, and Raquel E. Rodríguez

Characterization of Opioid-Binding Sites in Zebrafish Brain
J Pharmacol Exp Ther 2006 316: 900-904. Published online October 5, 2005; 10.1124/jpet.105.093492 [Abstract] [Full Text] [PDF]  

Linda M. Rorick-Kehn, Everett J. Perkins, Karen M. Knitowski, John C. Hart, Bryan G. Johnson, Darryle D. Schoepp, and David L. McKinzie

Improved Bioavailability of the mGlu2/3 Receptor Agonist LY354740 Using a Prodrug Strategy: In Vivo Pharmacology of LY544344
J Pharmacol Exp Ther 2006 316: 905-913. Published online October 13, 2005; 10.1124/jpet.105.091926 [Abstract] [Full Text] [PDF]  

Jun Hu, Kari Lindenberger, Gang Hu, Hai Wang, Ronald J. Lukas, and Jie Wu

Iptakalim as a Human Nicotinic Acetylcholine Receptor Antagonist
J Pharmacol Exp Ther 2006 316: 914-925. Published online October 13, 2005; 10.1124/jpet.105.094987 [Abstract] [Full Text] [PDF]  

Douglas McHugh, R. Shannon McMaster, Roger G. Pertwee, Sucharita Roy, Anu Mahadevan, Raj K. Razdan, and Ruth A. Ross

Novel Compounds That Interact with Both Leukotriene B₄ Receptors and Vanilloid TRPV1 Receptors
J Pharmacol Exp Ther 2006 316: 955-965. Published online October 5, 2005; 10.1124/jpet.105.095992 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Sharmilee P. Sawant, Ankur V. Dnyanmote, Mayurranjan S. Mitra, Jaya Chilakapati, Alan Warbritton, John R. Latendresse, and Harihara M. Mehendale

Protective Effect of Type 2 Diabetes on Acetaminophen-Induced Hepatotoxicity in Male Swiss-Webster Mice
J Pharmacol Exp Ther 2006 316: 507-519. Published online October 5, 2005; 10.1124/jpet.105.094326 [Abstract] [Full Text] [PDF]  

Poh-Gek Forkert, Brandie Millen, Lawrence H. Lash, David A. Putt, and Burhan I. Ghanayem

Pulmonary Bronchiolar Cytotoxicity and Formation of Dichloroacetyl Lysine Protein Adducts in Mice Treated with Trichloroethylene
J Pharmacol Exp Ther 2006 316: 520-529. Published online November 3, 2005; 10.1124/jpet.105.093062 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

K. Allegaert and D. Tibboel

Comments on "Shift from Biliary to Urinary Elimination of Acetaminophen-Glucuronide in Acetaminophen-Pretreated Rats"
J Pharmacol Exp Ther 2006 316: 966-967. [Full Text] [PDF]  

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