PERSPECTIVES IN PHARMACOLOGY:

Jay T. Goodwin and David E. Clark

In Silico Predictions of Blood-Brain Barrier Penetration: Considerations to "Keep in Mind"
J Pharmacol Exp Ther 2005 315: 477-483. Published online May 26, 2005; 10.1124/jpet.104.075705 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Naohiko Anzai, Promsuk Jutabha, Atsushi Enomoto, Hirokazu Yokoyama, Hiroshi Nonoguchi, Taku Hirata, Katsuko Shiraya, Xin He, Seok Ho Cha, Michio Takeda, Hiroki Miyazaki, Takeshi Sakata, Kimio Tomita, Takashi Igarashi, Yoshikatsu Kanai, and Hitoshi Endou

Functional Characterization of Rat Organic Anion Transporter 5 (Slc22a19) at the Apical Membrane of Renal Proximal Tubules
J Pharmacol Exp Ther 2005 315: 534-544. Published online August 3, 2005; 10.1124/jpet.105.088583 [Abstract] [Full Text] [PDF]  

Xue-Qing Li, Lars Weidolf, Roger Simonsson, and Tommy B. Andersson

Enantiomer/Enantiomer Interactions between the S- and R- Isomers of Omeprazole in Human Cytochrome P450 Enzymes: Major Role of CYP2C19 and CYP3A4
J Pharmacol Exp Ther 2005 315: 777-787. Published online August 10, 2005; 10.1124/jpet.105.090928 [Abstract] [Full Text] [PDF] Data Supplement  

Ryoko Sata, Hisakazu Ohtani, Masayuki Tsujimoto, Hideyasu Murakami, Noriko Koyabu, Takanori Nakamura, Takeshi Uchiumi, Michihiko Kuwano, Hideaki Nagata, Kiyomi Tsukimori, Hitoo Nakano, and Yasufumi Sawada

Functional Analysis of Organic Cation Transporter 3 Expressed in Human Placenta
J Pharmacol Exp Ther 2005 315: 888-895. Published online August 4, 2005; 10.1124/jpet.105.086827 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Vera C. Campbell, Theresa A. Kopajtic, Amy Hauck Newman, and Jonathan L. Katz

Assessment of the Influence of Histaminergic Actions on Cocaine-Like Effects of 3-Diphenylmethoxytropane Analogs
J Pharmacol Exp Ther 2005 315: 631-640. Published online July 29, 2005; 10.1124/jpet.105.090829 [Abstract] [Full Text] [PDF]  

Kentarou Ushijima, Hiromi Sakaguchi, Yuki Sato, Hideto To, Satoru Koyanagi, Shun Higuchi, and Shigehiro Ohdo

Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice
J Pharmacol Exp Ther 2005 315: 764-770. Published online August 3, 2005; 10.1124/jpet.105.088849 [Abstract] [Full Text] [PDF]  

Jennifer L. Mathews, Xuemei Peng, Wennan Xiong, Ao Zhang, S. Stevens Negus, John L. Neumeyer, and Jean M. Bidlack

Characterization of a Novel Bivalent Morphinan Possessing Agonist and µ Agonist/Antagonist Properties
J Pharmacol Exp Ther 2005 315: 821-827. Published online August 2, 2005; 10.1124/jpet.105.084343 [Abstract] [Full Text] [PDF]  

Andrew C. Barrett, S. Stevens Negus, Nancy K. Mello, and S. Barak Caine

Effect of GABA Agonists and GABA-A Receptor Modulators on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rats
J Pharmacol Exp Ther 2005 315: 858-871. Published online July 20, 2005; 10.1124/jpet.105.086033 [Abstract] [Full Text] [PDF]  

Sandor Kantor, Rita Jakus, Eszter Molnar, Norbert Gyongyosi, Attila Toth, Laszlo Detari, and Gyorgy Bagdy

Despite Similar Anxiolytic Potential, the 5-Hydroxytryptamine 2C Receptor Antagonist SB-242084 [6-Chloro-5-methyl-1-[2-(2-methylpyrid-3-yloxy)-pyrid-5-yl Carbamoyl] Indoline] and Chlordiazepoxide Produced Differential Effects on Electroencephalogram Power Spectra
J Pharmacol Exp Ther 2005 315: 921-930. Published online August 5, 2005; 10.1124/jpet.105.086413 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Subrata Chakrabarti, Olga Vitseva, David Iyu, Sonia Varghese, and Jane E. Freedman

The Effect of Dipyridamole on Vascular Cell-Derived Reactive Oxygen Species
J Pharmacol Exp Ther 2005 315: 494-500. Published online July 26, 2005; 10.1124/jpet.105.089987 [Abstract] [Full Text] [PDF]  

Carlos Hermenegildo, Pilar J. Oviedo, Miguel Angel García-Pérez, Juan J. Tarín, and Antonio Cano

Effects of Phytoestrogens Genistein and Daidzein on Prostacyclin Production by Human Endothelial Cells
J Pharmacol Exp Ther 2005 315: 722-728. Published online July 26, 2005; 10.1124/jpet.105.090456 [Abstract] [Full Text] [PDF]  

Robert Létienne, Jean-Christophe Blanchet, Estelle Sole, Gareth W. John, and Bruno Le Grand

Donitriptan Decreases Jugular Venous Oxygen Saturation in Rats in the Absence of Cranial Vasoconstriction: An Overlooked Mechanism of Antimigraine Action?
J Pharmacol Exp Ther 2005 315: 849-857. Published online July 18, 2005; 10.1124/jpet.105.090159 [Abstract] [Full Text] [PDF]  

Jan-Zhong Sheng, Dianna Wang, and Andrew P. Braun

DAF-FM (4-Amino-5-methylamino-2',7'-difluorofluorescein) Diacetate Detects Impairment of Agonist-Stimulated Nitric Oxide Synthesis by Elevated Glucose in Human Vascular Endothelial Cells: Reversal by Vitamin C and L-Sepiapterin
J Pharmacol Exp Ther 2005 315: 931-940. Published online August 10, 2005; 10.1124/jpet.105.087932 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Pierre-Luc Tremblay, François Berthod, Lucie Germain, and François A. Auger

In Vitro Evaluation of the Angiostatic Potential of Drugs Using an Endothelialized Tissue-Engineered Connective Tissue
J Pharmacol Exp Ther 2005 315: 510-516. Published online July 29, 2005; 10.1124/jpet.105.089524 [Abstract] [Full Text] [PDF]  

Luisa P. Cacheaux, Norbert Topf, Gareth R. Tibbs, Ulrich R. Schaefer, Roberto Levi, Neil L. Harrison, Geoffrey W. Abbott, and Peter A. Goldstein

Impairment of Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Intravenous General Anesthetic Propofol
J Pharmacol Exp Ther 2005 315: 517-525. Published online July 20, 2005; 10.1124/jpet.105.091801 [Abstract] [Full Text] [PDF]  

Marianna Kulka, Rene Dery, Drew Nahirney, Marek Duszyk, and A. Dean Befus

Differential Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by Interferon in Mast Cells and Epithelial Cells
J Pharmacol Exp Ther 2005 315: 563-570. Published online July 28, 2005; 10.1124/jpet.105.087528 [Abstract] [Full Text] [PDF]  

Kiyotaka Tanaka, Junichi Hasegawa, Kaori Asamitsu, and Takashi Okamoto

Prevention of the Ultraviolet B-Mediated Skin Photoaging by a Nuclear Factor B Inhibitor, Parthenolide
J Pharmacol Exp Ther 2005 315: 624-630. Published online July 18, 2005; 10.1124/jpet.105.088674 [Abstract] [Full Text] [PDF]  

Frank G. Bottone, Jr., Yuseok Moon, Brenda Alston-Mills, and Thomas E. Eling

Transcriptional Regulation of Activating Transcription Factor 3 Involves the Early Growth Response-1 Gene
J Pharmacol Exp Ther 2005 315: 668-677. Published online August 3, 2005; 10.1124/jpet.105.089607 [Abstract] [Full Text] [PDF]  

Xiaoqiu Liu, Shu Qiang Sun, and Rennolds S. Ostrom

Fibrotic Lung Fibroblasts Show Blunted Inhibition by cAMP Due to Deficient cAMP Response Element-Binding Protein Phosphorylation
J Pharmacol Exp Ther 2005 315: 678-687. Published online August 3, 2005; 10.1124/jpet.105.090324 [Abstract] [Full Text] [PDF]  

Frederick J. Ehlert

Analysis of Allosterism in Functional Assays
J Pharmacol Exp Ther 2005 315: 740-754. Published online July 26, 2005; 10.1124/jpet.105.090886 [Abstract] [Full Text] [PDF]  

Yuseok Moon, Wayne C. Glasgow, and Thomas E. Eling

Curcumin Suppresses Interleukin 1-Mediated Microsomal Prostaglandin E Synthase 1 by Altering Early Growth Response Gene 1 and Other Signaling Pathways
J Pharmacol Exp Ther 2005 315: 788-795. Published online August 4, 2005; 10.1124/jpet.105.084434 [Abstract] [Full Text] [PDF]  

Stephen Hsu, Douglas P. Dickinson, Haiyan Qin, Carol Lapp, David Lapp, James Borke, Douglas S. Walsh, Wendy B. Bollag, Hubert Stöppler, Tetsuya Yamamoto, Tokio Osaki, and George Schuster

Inhibition of Autoantigen Expression by (-)-Epigallocatechin-3-gallate (the Major Constituent of Green Tea) in Normal Human Cells
J Pharmacol Exp Ther 2005 315: 805-811. Published online July 26, 2005; 10.1124/jpet.105.090399 [Abstract] [Full Text] [PDF]  

Jennifer L. Shoemaker, Michael B. Ruckle, Philip R. Mayeux, and Paul L. Prather

Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 Receptors
J Pharmacol Exp Ther 2005 315: 828-838. Published online August 4, 2005; 10.1124/jpet.105.089474 [Abstract] [Full Text] [PDF]  

Alison A. Carter and Stephen J. Hill

Characterization of Isoprenaline- and Salmeterol-Stimulated Interactions between ₂-Adrenoceptors and -Arrestin 2 Using -Galactosidase Complementation in C2C12 Cells
J Pharmacol Exp Ther 2005 315: 839-848. Published online July 28, 2005; 10.1124/jpet.105.088914 [Abstract] [Full Text] [PDF]  

Hisao Yamamura, Shinya Ugawa, Takashi Ueda, and Shoichi Shimada

Evans Blue Is a Specific Antagonist of the Human Epithelial Na⁺ Channel -Subunit
J Pharmacol Exp Ther 2005 315: 965-969. Published online August 17, 2005; 10.1124/jpet.105.092775 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Shintaro Fumoto, Shigeru Kawakami, Kosuke Shigeta, Yuriko Higuchi, Fumiyoshi Yamashita, and Mitsuru Hashida

Interaction with Blood Components Plays a Crucial Role in Asialoglycoprotein Receptor-Mediated in Vivo Gene Transfer by Galactosylated Lipoplex
J Pharmacol Exp Ther 2005 315: 484-493. Published online July 20, 2005; 10.1124/jpet.105.089516 [Abstract] [Full Text] [PDF]  

Meng Guo, Richard J. Roman, John R. Falck, Paul A. Edwards, and A. Guillermo Scicli

Human U251 Glioma Cell Proliferation Is Suppressed by HET0016 [N-Hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a Selective Inhibitor of CYP4A
J Pharmacol Exp Ther 2005 315: 526-533. Published online August 4, 2005; 10.1124/jpet.105.088567 [Abstract] [Full Text] [PDF]  

Yu-Mu Lai, Noboru Fukuda, Takahiro Ueno, Hiroyuki Matsuda, Satoshi Saito, Koichi Matsumoto, Hirohito Ayame, Toshikazu Bando, Hiroshi Sugiyama, Hideo Mugishima, and Kazuo Serie

Synthetic Pyrrole-Imidazole Polyamide Inhibits Expression of the Human Transforming Growth Factor-1 Gene
J Pharmacol Exp Ther 2005 315: 571-575. Published online August 24, 2005; 10.1124/jpet.105.089086 [Abstract] [Full Text] [PDF]  

Robert Jan Veldman, Gerben A. Koning, Albert van Hell, Shuraila Zerp, Stefan R. Vink, Gert Storm, Marcel Verheij, and Wim J. van Blitterswijk

Coformulated N-Octanoyl-glucosylceramide Improves Cellular Delivery and Cytotoxicity of Liposomal Doxorubicin
J Pharmacol Exp Ther 2005 315: 704-710. Published online July 22, 2005; 10.1124/jpet.105.087486 [Abstract] [Full Text] [PDF]  

Lee Jia, Lori Coward, Gregory S. Gorman, Patricia E. Noker, and Joseph E. Tomaszewski

Pharmacoproteomic Effects of Isoniazid, Ethambutol, and N-Geranyl-N'-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37Rv
J Pharmacol Exp Ther 2005 315: 905-911. Published online August 5, 2005; 10.1124/jpet.105.087817 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

B. F. Burkey, X. Li, L. Bolognese, B. Balkan, M. Mone, M. Russell, T. E. Hughes, and P. R. Wang

Acute and Chronic Effects of the Incretin Enhancer Vildagliptin in Insulin-Resistant Rats
J Pharmacol Exp Ther 2005 315: 688-695. Published online July 18, 2005; 10.1124/jpet.105.087064 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Hao Xue, Ying-Li Zhang, Guo-Shu Liu, and Hai Wang

A New ATP-Sensitive Potassium Channel Opener Protects the Kidney from Hypertensive Damage in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2005 315: 501-509. Published online July 28, 2005; 10.1124/jpet.105.089722 [Abstract] [Full Text] [PDF]  

Naoyuki Kawao, Mami Nagataki, Keita Nagasawa, Satoko Kubo, Kelly Cushing, Tetsuyuki Wada, Fumiko Sekiguchi, Seiji Ichida, Morley D. Hollenberg, Wallace K. MacNaughton, Hiroyuki Nishikawa, and Atsufumi Kawabata

Signal Transduction for Proteinase-Activated Receptor-2-Triggered Prostaglandin E₂ Formation in Human Lung Epithelial Cells
J Pharmacol Exp Ther 2005 315: 576-589. Published online August 24, 2005; 10.1124/jpet.105.089490 [Abstract] [Full Text] [PDF]  

Jonathon D. S. Holt, Michael J. Watson, Jane P. Chang, Scott J. O'Neill, Ke Wei, William Pendergast, Peter J. Gengo, and Kwen-Jen Chang

DPI-221 [4-((-S)--((2S,5R)-2,5-Dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: A Novel Nonpeptide Receptor Agonist Producing Increased Micturition Interval in Normal Rats
J Pharmacol Exp Ther 2005 315: 601-608. Published online July 14, 2005; 10.1124/jpet.105.090498 [Abstract] [Full Text] [PDF]  

Huiling Liu, Abulkhair M. Mamoon, and Jerry M. Farley, Sr.

Prostanoids Secreted by Alveolar Macrophages Enhance Ionic Currents in Swine Tracheal Submucosal Gland Cells
J Pharmacol Exp Ther 2005 315: 729-739. Published online July 29, 2005; 10.1124/jpet.105.088542 [Abstract] [Full Text] [PDF]  

Sylvia Notenboom, David S. Miller, Leon H. Kuik, Paul Smits, Frans G. M. Russel, and Rosalinde Masereeuw

Short-Term Exposure of Renal Proximal Tubules to Gentamicin Increases Long-Term Multidrug Resistance Protein 2 (Abcc2) Transport Function and Reduces Nephrotoxicant Sensitivity
J Pharmacol Exp Ther 2005 315: 912-920. Published online August 5, 2005; 10.1124/jpet.105.089094 [Abstract] [Full Text] [PDF]  

Vasanthi Govindaraju, James G. Martin, Karim Maghni, Pasquale Ferraro, and Marie-Claire Michoud

The Effects of Extracellular Purines and Pyrimidines on Human Airway Smooth Muscle Cells
J Pharmacol Exp Ther 2005 315: 941-948. Published online August 12, 2005; 10.1124/jpet.105.089698 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Luisa M. Salter-Cid, Eric Wang, Anne M. O'Rourke, Andrew Miller, Hongfeng Gao, Li Huang, Arnie Garcia, and Matthew D. Linnik

Anti-Inflammatory Effects of Inhibiting the Amine Oxidase Activity of Semicarbazide-Sensitive Amine Oxidase
J Pharmacol Exp Ther 2005 315: 553-562. Published online August 4, 2005; 10.1124/jpet.105.089649 [Abstract] [Full Text] [PDF]  

Waldiceu A. Verri, Jr., Rodrigo O. Molina, Ieda R. S. Schivo, Thiago M. Cunha, Carlos A. Parada, Stephen Poole, Sérgio H. Ferreira, and Fernando Q. Cunha

Nociceptive Effect of Subcutaneously Injected Interleukin-12 Is Mediated by Endothelin (ET) Acting on ET_B Receptors in Rats
J Pharmacol Exp Ther 2005 315: 609-615. Published online July 15, 2005; 10.1124/jpet.105.089409 [Abstract] [Full Text] [PDF]  

Claudio Valenti, Cecilia Cialdai, Sandro Giuliani, Alessandro Lecci, Manuela Tramontana, Stefania Meini, Laura Quartara, and Carlo Alberto Maggi

MEN16132, a Novel Potent and Selective Nonpeptide Kinin B₂ Receptor Antagonist: In Vivo Activity on Bradykinin-Induced Bronchoconstriction and Nasal Mucosa Microvascular Leakage in Anesthetized Guinea Pigs
J Pharmacol Exp Ther 2005 315: 616-623. Published online July 18, 2005; 10.1124/jpet.105.088252 [Abstract] [Full Text] [PDF]  

Birgit Kraft and Hans G. Kress

Indirect CB₂ Receptor and Mediator-Dependent Stimulation of Human Whole-Blood Neutrophils by Exogenous and Endogenous Cannabinoids
J Pharmacol Exp Ther 2005 315: 641-647. Published online July 29, 2005; 10.1124/jpet.105.084269 [Abstract] [Full Text] [PDF]  

Naoko Kanda, Satsuki Koike, and Shinichi Watanabe

Prostaglandin E₂ Enhances Neurotrophin-4 Production via EP3 Receptor in Human Keratinocytes
J Pharmacol Exp Ther 2005 315: 796-804. Published online August 4, 2005; 10.1124/jpet.105.091645 [Abstract] [Full Text] [PDF]  

Jon G. Mabley, Eszter M. Horváth, Kanneganti G. K. Murthy, Zsuzsanna Zsengellér, Anne Vaslin, Rita Benko, Márk Kollai, and Csaba Szabó

Gender Differences in the Endotoxin-Induced Inflammatory and Vascular Responses: Potential Role of Poly(ADP-ribose) Polymerase Activation
J Pharmacol Exp Ther 2005 315: 812-820. Published online August 3, 2005; 10.1124/jpet.105.090480 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Takashi Furutani, Ken-ichi Takeyama, Masahiko Tanabe, Hiroshi Koutoku, Saya Ito, Nobuaki Taniguchi, Eriko Suzuki, Masafumi Kudoh, Masayuki Shibasaki, Hisataka Shikama, and Shigeaki Kato

Human Expanded Polyglutamine Androgen Receptor Mutants in Neurodegeneration as a Novel Ligand Target
J Pharmacol Exp Ther 2005 315: 545-552. Published online August 3, 2005; 10.1124/jpet.105.087643 [Abstract] [Full Text] [PDF]  

Michael S. Cowen, Elvan Djouma, and Andrew J. Lawrence

The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems
J Pharmacol Exp Ther 2005 315: 590-600. Published online July 13, 2005; 10.1124/jpet.105.090449 [Abstract] [Full Text] [PDF]  

Zachary A. Rodd, Richard L. Bell, Victoria K. McQueen, Michelle R. Davids, Cathleen C. Hsu, James M. Murphy, Ting-Kai Li, Lawrence Lumeng, and William J. McBride

Prolonged Increase in the Sensitivity of the Posterior Ventral Tegmental Area to the Reinforcing Effects of Ethanol following Repeated Exposure to Cycles of Ethanol Access and Deprivation
J Pharmacol Exp Ther 2005 315: 648-657. Published online August 2, 2005; 10.1124/jpet.105.084350 [Abstract] [Full Text] [PDF]  

Elena Escubedo, Carlos Chipana, Mónica Pérez-Sánchez, Jordi Camarasa, and David Pubill

Methyllycaconitine Prevents Methamphetamine-Induced Effects in Mouse Striatum: Involvement of 7 Nicotinic Receptors
J Pharmacol Exp Ther 2005 315: 658-667. Published online August 2, 2005; 10.1124/jpet.105.089748 [Abstract] [Full Text] [PDF]  

Yan-Ping Chen, Shao-Rui Chen, and Hui-Lin Pan

Effect of Morphine on Deep Dorsal Horn Projection Neurons Depends on Spinal GABAergic and Glycinergic Tone: Implications for Reduced Opioid Effect in Neuropathic Pain
J Pharmacol Exp Ther 2005 315: 696-703. Published online July 20, 2005; 10.1124/jpet.105.091314 [Abstract] [Full Text] [PDF]  

Richard H. P. Porter, Georg Jaeschke, Will Spooren, Theresa M. Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira, Andreas Mühlemann, Silvia Gatti, Vincent Mutel, and Pari Malherbe

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity
J Pharmacol Exp Ther 2005 315: 711-721. Published online July 22, 2005; 10.1124/jpet.105.089839 [Abstract] [Full Text] [PDF]  

Tooba A. Cheema, Caroline E. Ward, and Stephen K. Fisher

Subnanomolar Concentrations of Thrombin Enhance the Volume-Sensitive Efflux of Taurine from Human 1321N1 Astrocytoma Cells
J Pharmacol Exp Ther 2005 315: 755-763. Published online July 28, 2005; 10.1124/jpet.105.090787 [Abstract] [Full Text] [PDF]  

Ken Solt, Renna J. Stevens, Paul A. Davies, and Douglas E. Raines

General Anesthetic-Induced Channel Gating Enhancement of 5-Hydroxytryptamine Type 3 Receptors Depends on Receptor Subunit Composition
J Pharmacol Exp Ther 2005 315: 771-776. Published online August 4, 2005; 10.1124/jpet.105.090621 [Abstract] [Full Text] [PDF]  

Miho Hamada, Joseph P. Hendrick, Gregory R. Ryan, Mahomi Kuroiwa, Hideho Higashi, Masatoshi Tanaka, Angus C. Nairn, Paul Greengard, and Akinori Nishi

Nicotine Regulates DARPP-32 (Dopamine- and cAMP-Regulated Phosphoprotein of 32 kDa) Phosphorylation at Multiple Sites in Neostriatal Neurons
J Pharmacol Exp Ther 2005 315: 872-878. Published online July 22, 2005; 10.1124/jpet.105.090852 [Abstract] [Full Text] [PDF]  

Sinan Cavun, Gökhan Göktalay, and William R. Millington

Glycyl-Glutamine, an Endogenous -Endorphin-Derived Peptide, Inhibits Morphine-Induced Conditioned Place Preference, Tolerance, Dependence, and Withdrawal
J Pharmacol Exp Ther 2005 315: 949-958. Published online August 3, 2005; 10.1124/jpet.105.091553 [Abstract] [Full Text] [PDF]  

M. I. Damaj

Calcium-Acting Drugs Modulate Expression and Development of Chronic Tolerance to Nicotine-Induced Antinociception in Mice
J Pharmacol Exp Ther 2005 315: 959-964. Published online August 12, 2005; 10.1124/jpet.105.092460 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Cathleen Cover, Abdellah Mansouri, Tamara R. Knight, Mary Lynn Bajt, John J. Lemasters, Dominique Pessayre, and Hartmut Jaeschke

Peroxynitrite-Induced Mitochondrial and Endonuclease-Mediated Nuclear DNA Damage in Acetaminophen Hepatotoxicity
J Pharmacol Exp Ther 2005 315: 879-887. Published online August 4, 2005; 10.1124/jpet.105.088898 [Abstract] [Full Text] [PDF]  

Rudolfs K. Zalups and Sarfaraz Ahmad

Handling of the Homocysteine S-Conjugate of Methylmercury by Renal Epithelial Cells: Role of Organic Anion Transporter 1 and Amino Acid Transporters
J Pharmacol Exp Ther 2005 315: 896-904. Published online August 4, 2005; 10.1124/jpet.105.090530 [Abstract] [Full Text] [PDF]  

ERRATA:

Corrections to "Heme-Reversible Impairment of CYP2B1/2 Induction in Heme-Depleted Rat Hepatocytes in Primary Culture: Translational Control by a Hepatic -Subunit of the Eukaryotic Initiation Factor Kinase?"
J Pharmacol Exp Ther 2005 315: 970. [Full Text] [PDF]  

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