PERSPECTIVES IN PHARMACOLOGY:

Bela Kis, James A. Snipes, and David W. Busija

Acetaminophen and the Cyclooxygenase-3 Puzzle: Sorting out Facts, Fictions, and Uncertainties
J Pharmacol Exp Ther 2005 315: 1-7. Published online May 6, 2005; 10.1124/jpet.105.085431 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Angelo Mancinelli, Allan M. Evans, Roger L. Nation, and Antonio Longo

Uptake of L-Carnitine and Its Short-Chain Ester Propionyl-L-carnitine in the Isolated Perfused Rat Liver
J Pharmacol Exp Ther 2005 315: 118-124. Published online June 10, 2005; 10.1124/jpet.105.087890 [Abstract] [Full Text] [PDF]  

Simon Lowes, Destiny Sykes, Christopher M. Breen, Leigh J. Ragone, and David S. Miller

Multiple Components of 2,4-Dichlorophenoxyacetic Acid Uptake by Rat Choroid Plexus
J Pharmacol Exp Ther 2005 315: 136-143. Published online June 15, 2005; 10.1124/jpet.105.087056 [Abstract] [Full Text] [PDF]  

Haiqing Dai, Ying Chen, and William F. Elmquist

Distribution of the Novel Antifolate Pemetrexed to the Brain
J Pharmacol Exp Ther 2005 315: 222-229. Published online June 29, 2005; 10.1124/jpet.105.090043 [Abstract] [Full Text] [PDF]  

Scott M. Ocheltree, Hong Shen, Yongjun Hu, Richard F. Keep, and David E. Smith

Role and Relevance of Peptide Transporter 2 (PEPT2) in the Kidney and Choroid Plexus: In Vivo Studies with Glycylsarcosine in Wild-Type and PEPT2 Knockout Mice
J Pharmacol Exp Ther 2005 315: 240-247. Published online June 29, 2005; 10.1124/jpet.105.089359 [Abstract] [Full Text] [PDF]  

Krzysztof J. Reszka, Laura H. Britigan, and Bradley E. Britigan

Oxidation of Anthracyclines by Peroxidase Metabolites of Salicylic Acid
J Pharmacol Exp Ther 2005 315: 283-290. Published online June 28, 2005; 10.1124/jpet.105.089417 [Abstract] [Full Text] [PDF]  

Harunobu Tahara, Hiroyuki Kusuhara, Hitoshi Endou, Hermann Koepsell, Tomoki Imaoka, Eiichi Fuse, and Yuichi Sugiyama

A Species Difference in the Transport Activities of H₂ Receptor Antagonists by Rat and Human Renal Organic Anion and Cation Transporters
J Pharmacol Exp Ther 2005 315: 337-345. Published online July 8, 2005; 10.1124/jpet.105.088104 [Abstract] [Full Text] [PDF]  

K. Bach-Ngohou, K. Ouguerram, R. Frénais, P. Maugère, B. Ripolles-Piquer, Y. Zaïr, M. Krempf, and J. M. Bard

Influence of Atorvastatin on Apolipoprotein E and AI Kinetics in Patients with Type 2 Diabetes
J Pharmacol Exp Ther 2005 315: 363-369. Published online July 13, 2005; 10.1124/jpet.105.085522 [Abstract] [Full Text] [PDF]  

Lichuan Liu, Ernie Mak, Rommel G. Tirona, Eugene Tan, Phyllis M. Novikoff, Pijun Wang, Allan W. Wolkoff, and K. Sandy Pang

Vascular Binding, Blood Flow, Transporter, and Enzyme Interactions on the Processing of Digoxin in Rat Liver
J Pharmacol Exp Ther 2005 315: 433-448. Published online June 30, 2005; 10.1124/jpet.105.088039 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Becky Kinkead, Paul R. Dobner, Vasili Egnatashvili, Tiesha Murray, Nancy Deitemeyer, and Charles B. Nemeroff

Neurotensin-Deficient Mice Have Deficits in Prepulse Inhibition: Restoration by Clozapine but Not Haloperidol, Olanzapine, or Quetiapine
J Pharmacol Exp Ther 2005 315: 256-264. Published online June 29, 2005; 10.1124/jpet.105.087437 [Abstract] [Full Text] [PDF]  

Rajeev I. Desai, Theresa A. Kopajtic, Dawn French, Amy H. Newman, and Jonathan L. Katz

Relationship between in Vivo Occupancy at the Dopamine Transporter and Behavioral Effects of Cocaine, GBR 12909 [1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and Benztropine Analogs
J Pharmacol Exp Ther 2005 315: 397-404. Published online July 13, 2005; 10.1124/jpet.105.091231 [Abstract] [Full Text] [PDF]  

Emily M. Jutkiewicz, Sarah T. Kaminsky, Kenner C. Rice, John R. Traynor, and James H. Woods

Differential Behavioral Tolerance to the -Opioid Agonist SNC80 ([(+)-4-[(R)--[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley Rats
J Pharmacol Exp Ther 2005 315: 414-422. Published online July 13, 2005; 10.1124/jpet.105.088831 [Abstract] [Full Text] [PDF]  

Richard M. Allen, Regina M. Carelli, Linda A. Dykstra, Therese L. Suchey, and Carson V. Everett

Effects of the Competitive N-Methyl-D-aspartate Receptor Antagonist, LY235959 [(-)-6-Phosphonomethyl-deca-hydroisoquinoline-3-carboxylic Acid], on Responding for Cocaine under Both Fixed and Progressive Ratio Schedules of Reinforcement
J Pharmacol Exp Ther 2005 315: 449-457. Published online July 15, 2005; 10.1124/jpet.105.086355 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

C. Ian Spencer and James S. K. Sham

Mechanisms Underlying the Effects of the Pyrethroid Tefluthrin on Action Potential Duration in Isolated Rat Ventricular Myocytes
J Pharmacol Exp Ther 2005 315: 16-23. Published online June 24, 2005; 10.1124/jpet.105.084822 [Abstract] [Full Text] [PDF]  

Bernardo Rodríguez-Iturbe, Atilio Ferrebuz, Valentina Vanegas, Yasmir Quiroz, Sergio Mezzano, and Nosratola D. Vaziri

Early and Sustained Inhibition of Nuclear Factor-B Prevents Hypertension in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2005 315: 51-57. Published online June 10, 2005; 10.1124/jpet.105.088062 [Abstract] [Full Text] [PDF]  

Anita Pálfi, Ambrus Tóth, Gyozo Kulcsár, Katalin Hantó, Péter Deres, Éva Bartha, Róbert Halmosi, Eszter Szabados, László Czopf, Tamás Kálai, Kálmán Hideg, Balázs Sümegi, and Kálmán Tóth

The Role of Akt and Mitogen-Activated Protein Kinase Systems in the Protective Effect of Poly(ADP-Ribose) Polymerase Inhibition in Langendorff Perfused and in Isoproterenol-Damaged Rat Hearts
J Pharmacol Exp Ther 2005 315: 273-282. Published online June 10, 2005; 10.1124/jpet.105.088336 [Abstract] [Full Text] [PDF]  

Jan Kyselovic, Peter Martinka, Zuzana Batova, Andrea Gazova, and Theophile Godfraind

Calcium Channel Blocker Inhibits Western-Type Diet-Evoked Atherosclerosis Development in ApoE-Deficient Mice
J Pharmacol Exp Ther 2005 315: 320-328. Published online July 14, 2005; 10.1124/jpet.105.089847 [Abstract] [Full Text] [PDF] [Data Supplement]   

CELLULAR AND MOLECULAR:

Alexandre Mezentsev, Vladimir Mastyugin, Francesca Seta, Silvia Ashkar, Rowena Kemp, D. Sudarshan Reddy, John R. Falck, Michael W. Dunn, and Michal Laniado-Schwartzman

Transfection of Cytochrome P4504B1 into the Cornea Increases Angiogenic Activity of the Limbal Vessels
J Pharmacol Exp Ther 2005 315: 42-50. Published online July 11, 2005; 10.1124/jpet.105.088211 [Abstract] [Full Text] [PDF]  

Ariel R. Ase, Ramin Raouf, Danny Bélanger, Édith Hamel, and Philippe Séguéla

Potentiation of P2X1 ATP-Gated Currents by 5-Hydroxytryptamine 2A Receptors Involves Diacylglycerol-Dependent Kinases and Intracellular Calcium
J Pharmacol Exp Ther 2005 315: 144-154. Published online June 15, 2005; 10.1124/jpet.105.089045 [Abstract] [Full Text] [PDF]  

Cleber E. Teixeira, Zhekang Ying, and R. Clinton Webb

Proerectile Effects of the Rho-Kinase Inhibitor (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the Rat Penis
J Pharmacol Exp Ther 2005 315: 155-162. Published online June 23, 2005; 10.1124/jpet.105.086041 [Abstract] [Full Text] [PDF]  

Mohamed A. Abdelmegeed, Nicholas J. Carruthers, Kimberley J. Woodcroft, Sang K. Kim, and Raymond F. Novak

Acetoacetate Induces CYP2E1 Protein and Suppresses CYP2E1 mRNA in Primary Cultured Rat Hepatocytes
J Pharmacol Exp Ther 2005 315: 203-213. Published online June 24, 2005; 10.1124/jpet.105.084608 [Abstract] [Full Text] [PDF]  

Heng Xu, Xiaoying Wang, Darin Zimmerman, Emily S. Boja, Jiabei Wang, Edward J. Bilsky, and Richard B. Rothman

Chronic Morphine Up-Regulates G12 and Cytoskeletal Proteins in Chinese Hamster Ovary Cells Expressing the Cloned µ Opioid Receptor
J Pharmacol Exp Ther 2005 315: 248-255. Published online June 29, 2005; 10.1124/jpet.105.089367 [Abstract] [Full Text] [PDF]  

Marianne K. O. Grant and Esam E. El-Fakahany

Persistent Binding and Functional Antagonism by Xanomeline at the Muscarinic M₅ Receptor
J Pharmacol Exp Ther 2005 315: 313-319. Published online July 7, 2005; 10.1124/jpet.105.090134 [Abstract] [Full Text] [PDF]  

Christian Feißt, Lutz Franke, Giovanni Appendino, and Oliver Werz

Identification of Molecular Targets of the Oligomeric Nonprenylated Acylphloroglucinols from Myrtus communis and Their Implication as Anti-Inflammatory Compounds
J Pharmacol Exp Ther 2005 315: 389-396. Published online July 13, 2005; 10.1124/jpet.105.090720 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Gina E. Avila, Xi Zheng, Xiao Xing Cui, Amanda D. Ryan, Annette Hansson, Junghan Suh, Arnold B. Rabson, Richard L. Chang, Weichung Joe Shih, Yong Lin, Pamela Crowell, Yao Ping Lu, You Rong Lou, and Allan H. Conney

Inhibitory Effects of 12-O-Tetradecanoylphorbol-13-acetate Alone or in Combination with All-trans Retinoic Acid on the Growth of Cultured Human Pancreas Cancer Cells and Pancreas Tumor Xenografts in Immunodeficient Mice
J Pharmacol Exp Ther 2005 315: 170-187. Published online June 23, 2005; 10.1124/jpet.105.087585 [Abstract] [Full Text] [PDF]  

Jordi Martínez, Antonio Gutiérrez, Jesús Casas, Victoria Lladó, Alicia López-Bellan, Joan Besalduch, Ana Dopazo, and Pablo V. Escribá

The Repression of E2F-1 Is Critical for the Activity of Minerval against Cancer
J Pharmacol Exp Ther 2005 315: 466-474. Published online July 18, 2005; 10.1124/jpet.105.088716 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Juhyun Kim, Di Wu, Dong Jin Hwang, Duane D. Miller, and James T. Dalton

The Para Substituent of S-3-(Phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides Is a Major Structural Determinant of in Vivo Disposition and Activity of Selective Androgen Receptor Modulators
J Pharmacol Exp Ther 2005 315: 230-239. Published online June 29, 2005; 10.1124/jpet.105.088344 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

David L. Carbone, Jonathan A. Doorn, Zachary Kiebler, Brian R. Ickes, and Dennis R. Petersen

Modification of Heat Shock Protein 90 by 4-Hydroxynonenal in a Rat Model of Chronic Alcoholic Liver Disease
J Pharmacol Exp Ther 2005 315: 8-15. Published online June 10, 2005; 10.1124/jpet.105.088088 [Abstract] [Full Text] [PDF]  

Maria J. Monte, Maria R. Ballestero, Oscar Briz, Maria J. Perez, and Jose J. G. Marin

Proapoptotic Effect on Normal and Tumor Intestinal Cells of Cytostatic Drugs with Enterohepatic Organotropism
J Pharmacol Exp Ther 2005 315: 24-35. Published online June 28, 2005; 10.1124/jpet.105.086165 [Abstract] [Full Text] [PDF]  

Stefano Fiorucci, Giovanni Rizzo, Elisabetta Antonelli, Barbara Renga, Andrea Mencarelli, Luisa Riccardi, Antonio Morelli, Mark Pruzanski, and Roberto Pellicciari

Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis
J Pharmacol Exp Ther 2005 315: 58-68. Published online June 24, 2005; 10.1124/jpet.105.085597 [Abstract] [Full Text] [PDF] [Editorial Expression of Concern]   

P. C. M. Obiefuna, V. K. Batra, A. Nadeem, P. Borron, C. N. Wilson, and S. Jamal Mustafa

A Novel A₁ Adenosine Receptor Antagonist, L-97-1 [3-[2-(4-Aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], Reduces Allergic Responses to House Dust Mite in an Allergic Rabbit Model of Asthma
J Pharmacol Exp Ther 2005 315: 329-336. Published online July 14, 2005; 10.1124/jpet.105.088179 [Abstract] [Full Text] [PDF]  

Hisato Igarashi, Tetsuhide Ito, Samuel A. Mantey, Tapas K. Pradhan, Wei Hou, David H. Coy, and Robert T. Jensen

Development of Simplified Vasoactive Intestinal Peptide Analogs with Receptor Selectivity and Stability for Human Vasoactive Intestinal Peptide/Pituitary Adenylate Cyclase-Activating Polypeptide Receptors
J Pharmacol Exp Ther 2005 315: 370-381. Published online June 30, 2005; 10.1124/jpet.105.088823 [Abstract] [Full Text] [PDF]  

Eitaro Aihara, Masamune Hayashi, Yoko Sasaki, Atsushi Kobata, and Koji Takeuchi

Mechanisms Underlying Capsaicin-Stimulated Secretion in the Stomach: Comparison with Mucosal Acidification
J Pharmacol Exp Ther 2005 315: 423-432. Published online June 28, 2005; 10.1124/jpet.105.087619 [Abstract] [Full Text] [PDF]  

Anna-Karin Larsson, Magnus Bäck, Josephine Hjoberg, and Sven-Erik Dahlén

Inhibition of Nitric-Oxide Synthase Enhances Antigen-Induced Contractions and Increases Release of Cysteinyl-Leukotrienes in Guinea Pig Lung Parenchyma: Nitric Oxide as a Protective Factor
J Pharmacol Exp Ther 2005 315: 458-465. Published online July 15, 2005; 10.1124/jpet.105.086694 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Robert F. Stachlewitz, Michelle A. Hart, Brian Bettencourt, Tegest Kebede, Annette Schwartz, Sheldon E. Ratnofsky, David J. Calderwood, Wendy O. Waegell, and Gavin C. Hirst

A-770041, a Novel and Selective Small-Molecule Inhibitor of Lck, Prevents Heart Allograft Rejection
J Pharmacol Exp Ther 2005 315: 36-41. Published online July 12, 2005; 10.1124/jpet.105.089169 [Abstract] [Full Text] [PDF]  

Alf Lamprecht, Hiromitsu Yamamoto, Hirofumi Takeuchi, and Yoshiaki Kawashima

Nanoparticles Enhance Therapeutic Efficiency by Selectively Increased Local Drug Dose in Experimental Colitis in Rats
J Pharmacol Exp Ther 2005 315: 196-202. Published online June 24, 2005; 10.1124/jpet.105.088146 [Abstract] [Full Text] [PDF]  

Mark A. Pattoli, John F. MacMaster, Kurt R. Gregor, and James R. Burke

Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of IB Kinase through Suppression of Metalloproteinase Expression
J Pharmacol Exp Ther 2005 315: 382-388. Published online July 11, 2005; 10.1124/jpet.105.087569 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Rajesh Narendran, Dah-Ren Hwang, Mark Slifstein, Yuying Hwang, Yiyun Huang, Jesper Ekelund, Olivier Guillin, Erica Scher, Diana Martinez, and Marc Laruelle

Measurement of the Proportion of D₂ Receptors Configured in State of High Affinity for Agonists in Vivo: A Positron Emission Tomography Study Using [¹¹C]N-Propyl-norapomorphine and [¹¹C]Raclopride in Baboons
J Pharmacol Exp Ther 2005 315: 80-90. Published online July 12, 2005; 10.1124/jpet.105.090068 [Abstract] [Full Text] [PDF]  

Yvan Dumont, Emmanuel Moyse, Alain Fournier, and Rémi Quirion

Evidence for the Existence of an Additional Class of Neuropeptide Y Receptor Sites in Rat Brain
J Pharmacol Exp Ther 2005 315: 99-108. Published online June 9, 2005; 10.1124/jpet.105.089300 [Abstract] [Full Text] [PDF]  

Renato Corradetti, Boris Mlinar, Chiara Falsini, Anna Maria Pugliese, Antonio Cilia, Carla Destefani, and Rodolfo Testa

Differential Effects of the 5-Hydroxytryptamine (5-HT)_1A Receptor Inverse Agonists Rec 27/0224 and Rec 27/0074 on Electrophysiological Responses to 5-HT_1A Receptor Activation in Rat Dorsal Raphe Nucleus and Hippocampus in Vitro
J Pharmacol Exp Ther 2005 315: 109-117. Published online June 10, 2005; 10.1124/jpet.105.087809 [Abstract] [Full Text] [PDF]  

Shigeki Moriguchi, Xilong Zhao, William Marszalec, Jay Z. Yeh, and Toshio Narahashi

Modulation of N-Methyl-D-aspartate Receptors by Donepezil in Rat Cortical Neurons
J Pharmacol Exp Ther 2005 315: 125-135. Published online June 10, 2005; 10.1124/jpet.105.087908 [Abstract] [Full Text] [PDF]  

Atsuyuki Kohara, Takashi Toya, Seiji Tamura, Tomonari Watabiki, Yukinori Nagakura, Yoshitsugu Shitaka, Satoshi Hayashibe, Shigeki Kawabata, and Masamichi Okada

Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and Noncompetitive Antagonist of Metabotropic Glutamate Receptor Type 1
J Pharmacol Exp Ther 2005 315: 163-169. Published online June 23, 2005; 10.1124/jpet.105.087171 [Abstract] [Full Text] [PDF]  

Marcello Canonaco, Maria Madeo, Raffaella Alò, Giuseppina Giusi, Teresa Granata, Antonio Carelli, Alessia Canonaco, and Rosa Maria Facciolo

The Histaminergic Signaling System Exerts a Neuroprotective Role against Neurodegenerative-Induced Processes in the Hamster
J Pharmacol Exp Ther 2005 315: 188-195. Published online June 23, 2005; 10.1124/jpet.105.088153 [Abstract] [Full Text] [PDF]  

Michelle K. Winter and Kenneth E. McCarson

G-Protein Activation by Neurokinin-1 Receptors Is Dynamically Regulated during Persistent Nociception
J Pharmacol Exp Ther 2005 315: 214-221. Published online June 28, 2005; 10.1124/jpet.105.089565 [Abstract] [Full Text] [PDF]  

Marie-Bernadette Assié, Véronique Ravailhe, Valérie Faucillon, and Adrian Newman-Tancredi

Contrasting Contribution of 5-Hydroxytryptamine 1A Receptor Activation to Neurochemical Profile of Novel Antipsychotics: Frontocortical Dopamine and Hippocampal Serotonin Release in Rat Brain
J Pharmacol Exp Ther 2005 315: 265-272. Published online June 29, 2005; 10.1124/jpet.105.087163 [Abstract] [Full Text] [PDF]  

Raji Mathew, Peethambaran Arun, Chikkathur N. Madhavarao, John R. Moffett, and M. A. Aryan Namboodiri

Progress toward Acetate Supplementation Therapy for Canavan Disease: Glyceryl Triacetate Administration Increases Acetate, but Not N-Acetylaspartate, Levels in Brain
J Pharmacol Exp Ther 2005 315: 297-303. Published online July 7, 2005; 10.1124/jpet.105.087536 [Abstract] [Full Text] [PDF]  

Petrine Wellendorph, Signe Høg, Jeremy R. Greenwood, Anne de Lichtenberg, Birgitte Nielsen, Bente Frølund, Lotte Brehm, Rasmus P. Clausen, and Hans Bräuner-Osborne

Novel Cyclic -Hydroxybutyrate (GHB) Analogs with High Affinity and Stereoselectivity of Binding to GHB Sites in Rat Brain
J Pharmacol Exp Ther 2005 315: 346-351. Published online July 12, 2005; 10.1124/jpet.105.090472 [Abstract] [Full Text] [PDF] [Data Supplement]   

Shi-Bing Yang, Felix Major, Lutz F. Tietze, and Marjan Rupnik

Block of Delayed-Rectifier Potassium Channels by Reduced Haloperidol and Related Compounds in Mouse Cortical Neurons
J Pharmacol Exp Ther 2005 315: 352-362. Published online July 12, 2005; 10.1124/jpet.105.086561 [Abstract] [Full Text] [PDF]  

Kristen K. Ford, Michele Matchett, James E. Krause, and Weifeng Yu

The P2X₃ Antagonist P¹, P⁵-Di[inosine-5'] Pentaphosphate Binds to the Desensitized State of the Receptor in Rat Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther 2005 315: 405-413. Published online July 13, 2005; 10.1124/jpet.105.088070 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Faneng Sun, Vellareddy Anantharam, Calivarathan Latchoumycandane, Arthi Kanthasamy, and Anumantha G. Kanthasamy

Dieldrin Induces Ubiquitin-Proteasome Dysfunction in -Synuclein Overexpressing Dopaminergic Neuronal Cells and Enhances Susceptibility to Apoptotic Cell Death
J Pharmacol Exp Ther 2005 315: 69-79. Published online June 29, 2005; 10.1124/jpet.105.084632 [Abstract] [Full Text] [PDF]  

George A. Ricaurte, Annis O. Mechan, Jie Yuan, George Hatzidimitriou, Tao Xie, Andrew H. Mayne, and Una D. McCann

Amphetamine Treatment Similar to That Used in the Treatment of Adult Attention-Deficit/Hyperactivity Disorder Damages Dopaminergic Nerve Endings in the Striatum of Adult Nonhuman Primates
J Pharmacol Exp Ther 2005 315: 91-98. Published online July 13, 2005; 10.1124/jpet.105.087916 [Abstract] [Full Text] [PDF]  

Simona Magi, Pasqualina Castaldo, Giuseppina Carrieri, Antonella Scorziello, Gianfranco Di Renzo, and Salvatore Amoroso

Involvement of Na⁺-Ca²⁺ Exchanger in Intracellular Ca²⁺ Increase and Neuronal Injury Induced by Polychlorinated Biphenyls in Human Neuroblastoma SH-SY5Y Cells
J Pharmacol Exp Ther 2005 315: 291-296. Published online July 11, 2005; 10.1124/jpet.105.088948 [Abstract] [Full Text] [PDF]  

Irina G. Kessova and Arthur I. Cederbaum

The Effect of CYP2E1-Dependent Oxidant Stress on Activity of Proteasomes in HepG2 Cells
J Pharmacol Exp Ther 2005 315: 304-312. Published online July 7, 2005; 10.1124/jpet.105.088047 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Resistance of Human Astrocytoma Cells to Apoptosis Induced by Mitochondria-Damaging Agents: Possible Implications for Anticancer Therapy"
J Pharmacol Exp Ther 2005 315: 475. [Full Text] [PDF]  

Correction to "Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca²⁺-Activated K⁺ (Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception"
J Pharmacol Exp Ther 2005 315: 476. [Full Text] [PDF]  

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