PERSPECTIVES IN PHARMACOLOGY:

Basil Rigas and Khosrow Kashfi

Cancer Prevention: A New Era beyond Cyclooxygenase-2
J Pharmacol Exp Ther 2005 314: 1-8. Published online April 1, 2005; 10.1124/jpet.104.080564 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Xunshan Ding and Jeff L. Staudinger

The Ratio of Constitutive Androstane Receptor to Pregnane X Receptor Determines the Activity of Guggulsterone against the Cyp2b10 Promoter
J Pharmacol Exp Ther 2005 314: 120-127. Published online April 15, 2005; 10.1124/jpet.105.085225 [Abstract] [Full Text] [PDF]  

Xing-Mei Han, Gene Lee, Colleen Hefner, Jacquelyn J. Maher, and Maria Almira Correia

Heme-Reversible Impairment of CYP2B1/2 Induction in Heme-Depleted Rat Hepatocytes in Primary Culture: Translational Control by a Hepatic -Subunit of the Eukaryotic Initiation Factor Kinase?
J Pharmacol Exp Ther 2005 314: 128-138. Published online March 15, 2005; 10.1124/jpet.105.084699 [Abstract] [Full Text] [PDF] Erratum  

Aleksandra Galetin, Kiyomi Ito, David Hallifax, and J. Brian Houston

CYP3A4 Substrate Selection and Substitution in the Prediction of Potential Drug-Drug Interactions
J Pharmacol Exp Ther 2005 314: 180-190. Published online March 22, 2005; 10.1124/jpet.104.082826 [Abstract] [Full Text] [PDF]  

Helen H. Usansky and Patrick J. Sinko

Estimating Human Drug Oral Absorption Kinetics from Caco-2 Permeability Using an Absorption-Disposition Model: Model Development and Evaluation and Derivation of Analytical Solutions for k_a and F_a
J Pharmacol Exp Ther 2005 314: 391-399. Published online April 15, 2005; 10.1124/jpet.104.076182 [Abstract] [Full Text] [PDF]  

Jim J. Xiao, Ying Huang, Zunyan Dai, Wolfgang Sadée, Jiyun Chen, Shujun Liu, Guido Marcucci, John Byrd, Joseph M. Covey, John Wright, Michael Grever, and Kenneth K. Chan

Chemoresistance to Depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-Ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] Is Mediated by Reversible MDR1 Induction in Human Cancer Cell Lines
J Pharmacol Exp Ther 2005 314: 467-475. Published online April 15, 2005; 10.1124/jpet.105.083956 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Wouter Koek, Lawrence P. Carter, R. J. Lamb, Weibin Chen, Huifang Wu, Andrew Coop, and Charles P. France

Discriminative Stimulus Effects of -Hydroxybutyrate (GHB) in Rats Discriminating GHB from Baclofen and Diazepam
J Pharmacol Exp Ther 2005 314: 170-179. Published online March 17, 2005; 10.1124/jpet.105.083394 [Abstract] [Full Text] [PDF]  

Glenn W. Stevenson, John E. Folk, Kenner C. Rice, and S. Stevens Negus

Interactions between and µ Opioid Agonists in Assays of Schedule-Controlled Responding, Thermal Nociception, Drug Self-Administration, and Drug versus Food Choice in Rhesus Monkeys: Studies with SNC80 [(+)-4-[(R)--((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Heroin
J Pharmacol Exp Ther 2005 314: 221-231. Published online March 25, 2005; 10.1124/jpet.104.082685 [Abstract] [Full Text] [PDF]  

M. P. G. Korsgaard, B. P. Hartz, W. D. Brown, P. K. Ahring, D. Strøbæk, and N. R. Mirza

Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal K_v7 Channels
J Pharmacol Exp Ther 2005 314: 282-292. Published online April 6, 2005; 10.1124/jpet.105.083923 [Abstract] [Full Text] [PDF]  

Gregory T. Collins, Jeffrey M. Witkin, Amy H. Newman, Kjell A. Svensson, Peter Grundt, Jianjing Cao, and James H. Woods

Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior
J Pharmacol Exp Ther 2005 314: 310-319. Published online April 15, 2005; 10.1124/jpet.105.085472 [Abstract] [Full Text] [PDF]  

S. A. Varvel, D. T. Bridgen, Q. Tao, B. F. Thomas, B. R. Martin, and A. H. Lichtman

⁹-Tetrahydrocannbinol Accounts for the Antinociceptive, Hypothermic, and Cataleptic Effects of Marijuana in Mice
J Pharmacol Exp Ther 2005 314: 329-337. Published online April 14, 2005; 10.1124/jpet.104.080739 [Abstract] [Full Text] [PDF]  

David A. White and Stephen G. Holtzman

Discriminative Stimulus Effects of Acute Morphine Followed by Naltrexone in the Squirrel Monkey: A Further Characterization
J Pharmacol Exp Ther 2005 314: 374-382. Published online April 20, 2005; 10.1124/jpet.104.078584 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

A. Elizabeth Linder, Lynnette P. McCluskey, Kenneth R. Cole, III, Katherine M. Lanning, and R. Clinton Webb

Dynamic Association of Nitric Oxide Downstream Signaling Molecules with Endothelial Caveolin-1 in Rat Aorta
J Pharmacol Exp Ther 2005 314: 9-15. Published online March 18, 2005; 10.1124/jpet.105.083634 [Abstract] [Full Text] [PDF]  

Shiow-Lin Pan, Jih-Hwa Guh, Chieh-Yu Peng, Shih-Wei Wang, Ya-Ling Chang, Fong-Chi Cheng, Jau-Hsiang Chang, Sheng-Chu Kuo, Fang-Yu Lee, and Che-Ming Teng

YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Inhibits Endothelial Cell Functions Induced by Angiogenic Factors in Vitro and Angiogenesis in Vivo Models
J Pharmacol Exp Ther 2005 314: 35-42. Published online March 22, 2005; 10.1124/jpet.105.085126 [Abstract] [Full Text] [PDF]  

Jon C. Henry, Mary M. Bonar, Patrick N. Kearns, Hongmei Cui, Megan M. Mutchler, Michael V. Martin, Anthony R. Orsini, Howard L. Elford, Charles A. Bush, Jay L. Zweier, and Arturo J. Cardounel

Inhibition of Ribonucleotide Reductase Reduces Neointimal Formation following Balloon Injury
J Pharmacol Exp Ther 2005 314: 70-76. Published online April 6, 2005; 10.1124/jpet.105.083980 [Abstract] [Full Text] [PDF]  

Noriyuki Miyata, Takayuki Seki, Yu Tanaka, Tomohiro Omura, Kazuo Taniguchi, Mariko Doi, Kagumi Bandou, Shunichi Kametani, Masakazu Sato, Shigeru Okuyama, Liana Cambj-Sapunar, David R. Harder, and Richard J. Roman

Beneficial Effects of a New 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, TS-011 [N-(3-Chloro-4-morpholin-4-yl) Phenyl-N'-hydroxyimido Formamide], on Hemorrhagic and Ischemic Stroke
J Pharmacol Exp Ther 2005 314: 77-85. Published online April 14, 2005; 10.1124/jpet.105.083964 [Abstract] [Full Text] [PDF] Data Supplement  

Yingfan Zhang, George G. Rodney, and Martin F. Schneider

Effects of Azumolene on Ca²⁺ Sparks in Skeletal Muscle Fibers
J Pharmacol Exp Ther 2005 314: 94-102. Published online April 14, 2005; 10.1124/jpet.105.084046 [Abstract] [Full Text] [PDF]  

Craig N. Morrell, Kenji Matsushita, and Charles J. Lowenstein

A Novel Inhibitor of N-Ethylmaleimide-Sensitive Factor Decreases Leukocyte Trafficking and Peritonitis
J Pharmacol Exp Ther 2005 314: 155-161. Published online March 18, 2005; 10.1124/jpet.104.082529 [Abstract] [Full Text] [PDF]  

Dnyaneshwar U. Bawankule, K. Sathishkumar, Kautuk K. Sardar, Debabrata Chanda, A. Vamsi Krishna, Vellanki Ravi Prakash, and Santosh K. Mishra

BAY 41-2272 [5-Cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-Induced Dilation in Ovine Pulmonary Artery: Role of Sodium Pump
J Pharmacol Exp Ther 2005 314: 207-213. Published online March 25, 2005; 10.1124/jpet.105.083824 [Abstract] [Full Text] [PDF]  

Béatrice Hechler, Stéphanie Magnenat, Maddalena L. Zighetti, Matthias U. Kassack, Heiko Ullmann, Jean-Pierre Cazenave, Richard Evans, Marco Cattaneo, and Christian Gachet

Inhibition of Platelet Functions and Thrombosis through Selective or Nonselective Inhibition of the Platelet P2 Receptors with Increasing Doses of NF449 [4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic Acid Octasodium Salt]
J Pharmacol Exp Ther 2005 314: 232-243. Published online March 25, 2005; 10.1124/jpet.105.084673 [Abstract] [Full Text] [PDF]  

Xiang Fang, Shanming Hu, Takaho Watanabe, Neal L. Weintraub, Gary D. Snyder, Jianrong Yao, Yi Liu, John Y.-J. Shyy, Bruce D. Hammock, and Arthur A. Spector

Activation of Peroxisome Proliferator-Activated Receptor by Substituted Urea-Derived Soluble Epoxide Hydrolase Inhibitors
J Pharmacol Exp Ther 2005 314: 260-270. Published online March 29, 2005; 10.1124/jpet.105.085605 [Abstract] [Full Text] [PDF]  

Héric Valette, Michel Bottlaender, Frédéric Dollé, Christine Coulon, Michèle Ottaviani, and André Syrota

Acute Inhibition of Cardiac Monoamine Oxidase A after Tobacco Smoke Inhalation: Validation Study of [¹¹C]Befloxatone in Rats Followed by a Positron Emission Tomography Application in Baboons
J Pharmacol Exp Ther 2005 314: 431-436. Published online April 15, 2005; 10.1124/jpet.105.085704 [Abstract] [Full Text] [PDF]  

Ramesh Saeedi, Mark Grist, Richard B. Wambolt, Anne Bescond-Jacquet, Arnaud Lucien, and Michael F. Allard

Trimetazidine Normalizes Postischemic Function of Hypertrophied Rat Hearts
J Pharmacol Exp Ther 2005 314: 446-454. Published online April 19, 2005; 10.1124/jpet.104.082636 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Sanjoy Roychowdhury, Piyush M. Vyas, Timothy P. Reilly, Anthony A. Gaspari, and Craig K. Svensson

Characterization of the Formation and Localization of Sulfamethoxazole and Dapsone-Associated Drug-Protein Adducts in Human Epidermal Keratinocytes
J Pharmacol Exp Ther 2005 314: 43-52. Published online March 22, 2005; 10.1124/jpet.105.086009 [Abstract] [Full Text] [PDF]  

Karima Ferrani-Kile and Steven W. Leslie

Modulation of Protein Tyrosine Phosphatase Activity Alters the Subunit Assembly in Native N-Methyl-D-aspartate Receptor Complex
J Pharmacol Exp Ther 2005 314: 86-93. Published online April 18, 2005; 10.1124/jpet.105.083535 [Abstract] [Full Text] [PDF]  

Kathleen M. Krueger, David G. Witte, Lynne Ireland-Denny, Thomas R. Miller, John L. Baranowski, Steve Buckner, Ivan Milicic, Timothy A. Esbenshade, and Arthur A. Hancock

G Protein-Dependent Pharmacology of Histamine H₃ Receptor Ligands: Evidence for Heterogeneous Active State Receptor Conformations
J Pharmacol Exp Ther 2005 314: 271-281. Published online April 8, 2005; 10.1124/jpet.104.078865 [Abstract] [Full Text] [PDF]  

Diane S. Allen-Gipson, Anthony A. Floreani, Art J. Heires, Sam D. Sanderson, Richard G. MacDonald, and Todd A. Wyatt

Cigarette Smoke Extract Increases C5a Receptor Expression in Human Bronchial Epithelial Cells
J Pharmacol Exp Ther 2005 314: 476-482. Published online April 20, 2005; 10.1124/jpet.104.079822 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Fuminori Teraishi, Shuhong Wu, Jiichiro Sasaki, Lidong Zhang, Hong-Bo Zhu, John J. Davis, and Bingliang Fang

P-Glycoprotein-Independent Apoptosis Induction by a Novel Synthetic Compound, MMPT [5-[(4-Methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone]
J Pharmacol Exp Ther 2005 314: 355-362. Published online April 14, 2005; 10.1124/jpet.105.085654 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Peer B. Jacobson, Thomas W. von Geldern, Lars Öhman, Marie Österland, Jiahong Wang, Bradley Zinker, Denise Wilcox, Phong T. Nguyen, Amanda Mika, Steven Fung, Thomas Fey, Annika Goos-Nilsson, Marlena Grynfarb, Tomas Barkhem, Kennan Marsh, David W. A. Beno, Bach Nga-Nguyen, Philip R. Kym, James T. Link, Noah Tu, Dale S. Edgerton, Alan Cherrington, Suad Efendic, Benjamin C. Lane, and Terry J. Opgenorth

Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes
J Pharmacol Exp Ther 2005 314: 191-200. Published online March 22, 2005; 10.1124/jpet.104.081257 [Abstract] [Full Text] [PDF]  

Rodney A. Velliquette, Jacob E. Friedman, J. Shao, Bei B. Zhang, and Paul Ernsberger

Therapeutic Actions of an Insulin Receptor Activator and a Novel Peroxisome Proliferator-Activated Receptor Agonist in the Spontaneously Hypertensive Obese Rat Model of Metabolic Syndrome X
J Pharmacol Exp Ther 2005 314: 422-430. Published online April 15, 2005; 10.1124/jpet.104.080606 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Heather L. Cameron and Mary H. Perdue

Stress Impairs Murine Intestinal Barrier Function: Improvement by Glucagon-Like Peptide-2
J Pharmacol Exp Ther 2005 314: 214-220. Published online March 29, 2005; 10.1124/jpet.105.085373 [Abstract] [Full Text] [PDF]  

Aya Yokota, Masaki Taniguchi, Yuka Takahira, Akiko Tanaka, and Koji Takeuchi

Rofecoxib Produces Intestinal but Not Gastric Damage in the Presence of a Low Dose of Indomethacin in Rats
J Pharmacol Exp Ther 2005 314: 302-309. Published online April 14, 2005; 10.1124/jpet.105.084962 [Abstract] [Full Text] [PDF]  

Shougang Zhuang and Rick G. Schnellmann

Suramin Promotes Proliferation and Scattering of Renal Epithelial Cells
J Pharmacol Exp Ther 2005 314: 383-390. Published online April 15, 2005; 10.1124/jpet.104.080648 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Su-Jin Kim, Hyun-Ja Jeong, In-Young Choi, Kang-Min Lee, Rae-Kil Park, Seung-Heon Hong, and Hyung-Min Kim

Cyclooxygenase-2 Inhibitor SC-236 [4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] Benzenesulfonamide] Suppresses Nuclear Factor-B Activation and Phosphorylation of p38 Mitogen-Activated Protein Kinase, Extracellular Signal-Regulated Kinase, and c-Jun N-Terminal Kinase in Human Mast Cell Line Cells
J Pharmacol Exp Ther 2005 314: 27-34. Published online March 22, 2005; 10.1124/jpet.104.082792 [Abstract] [Full Text] [PDF]  

Galen M. Pieper, Vani Nilakantan, Min Chen, Jing Zhou, Ashwani K. Khanna, James D. Henderson, Jr., Christopher P. Johnson, Allan M. Roza, and Csaba Szabó

Protective Mechanisms of a Metalloporphyrinic Peroxynitrite Decomposition Catalyst, WW85, in Rat Cardiac Transplants
J Pharmacol Exp Ther 2005 314: 53-60. Published online March 22, 2005; 10.1124/jpet.105.083493 [Abstract] [Full Text] [PDF] EDITOR'S NOTE  

Árpád Szabó, Zsuzsanna Helyes, Katalin Sándor, Andrea Bite, Erika Pintér, József Németh, Ágnes Bánvölgyi, Kata Bölcskei, Krisztián Elekes, and János Szolcsányi

Role of Transient Receptor Potential Vanilloid 1 Receptors in Adjuvant-Induced Chronic Arthritis: In Vivo Study Using Gene-Deficient Mice
J Pharmacol Exp Ther 2005 314: 111-119. Published online April 14, 2005; 10.1124/jpet.104.082487 [Abstract] [Full Text] [PDF]  

Hideki Mimura, Toshihide Ikemura, Osamu Kotera, Masatsugu Sawada, Satoshi Tashiro, Eiichi Fuse, Kimihisa Ueno, Haruhiko Manabe, Etsuo Ohshima, Akira Karasawa, and Hiromasa Miyaji

Inhibitory Effect of the 4-Aminotetrahydroquinoline Derivatives, Selective Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cell Antagonists, on Eosinophil Migration Induced by Prostaglandin D₂
J Pharmacol Exp Ther 2005 314: 244-251. Published online March 29, 2005; 10.1124/jpet.104.081539 [Abstract] [Full Text] [PDF]  

Takayuki Mimura, Yuichi Shinozaki, Hisashi Kawasaki, and Hiroyuki Iwamura

JTP-27536 [(+)-1,3-Dihydroxy-2-hydroxymethylpropyl-2-ammonium 2-[(R)-3-Cyclo-hexyl-1-phenylpropyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate Monohydrate], a Novel Inhibitor of Immunoglobulins and Interleukin-5 with Anti-Inflammatory Properties in Mouse Allergic Dermatitis Model
J Pharmacol Exp Ther 2005 314: 293-301. Published online April 8, 2005; 10.1124/jpet.104.080846 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Hussam Jourdi, Xiaoying Lu, Ted Yanagihara, Julie C. Lauterborn, Xiaoning Bi, Christine M. Gall, and Michel Baudry

Prolonged Positive Modulation of -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Induces Calpain-Mediated PSD-95/Dlg/ZO-1 Protein Degradation and AMPA Receptor Down-Regulation in Cultured Hippocampal Slices
J Pharmacol Exp Ther 2005 314: 16-26. Published online March 22, 2005; 10.1124/jpet.105.083873 [Abstract] [Full Text] [PDF]  

Roberto I. Melendez, Jompobe Vuthiganon, and Peter W. Kalivas

Regulation of Extracellular Glutamate in the Prefrontal Cortex: Focus on the Cystine Glutamate Exchanger and Group I Metabotropic Glutamate Receptors
J Pharmacol Exp Ther 2005 314: 139-147. Published online March 15, 2005; 10.1124/jpet.104.081521 [Abstract] [Full Text] [PDF]  

Daniella L. Muller and Ellen M. Unterwald

D1 Dopamine Receptors Modulate FosB Induction in Rat Striatum after Intermittent Morphine Administration
J Pharmacol Exp Ther 2005 314: 148-154. Published online March 16, 2005; 10.1124/jpet.105.083410 [Abstract] [Full Text] [PDF]  

S. Akerman and P. J. Goadsby

The Role of Dopamine in a Model of Trigeminovascular Nociception
J Pharmacol Exp Ther 2005 314: 162-169. Published online March 18, 2005; 10.1124/jpet.105.083139 [Abstract] [Full Text] [PDF]  

D. J. Lodge and A. A. Grace

Acute and Chronic Corticotropin-Releasing Factor 1 Receptor Blockade Inhibits Cocaine-Induced Dopamine Release: Correlation with Dopamine Neuron Activity
J Pharmacol Exp Ther 2005 314: 201-206. Published online March 22, 2005; 10.1124/jpet.105.084913 [Abstract] [Full Text] [PDF]  

Kazunari Hirata, Hidetoshi Yamaguchi, Yusaku Takamura, Akiko Takagi, Tetsuo Fukushima, Noboru Iwakami, Akihito Saitoh, Masaya Nakagawa, and Tatsuo Yamada

A Novel Neurotrophic Agent, T-817MA [1-{3-[2-(1-Benzothiophen-5-yl) Ethoxy] Propyl}-3-azetidinol Maleate], Attenuates Amyloid--Induced Neurotoxicity and Promotes Neurite Outgrowth in Rat Cultured Central Nervous System Neurons
J Pharmacol Exp Ther 2005 314: 252-259. Published online March 29, 2005; 10.1124/jpet.105.083543 [Abstract] [Full Text] [PDF]  

Paromita Das and Glenn H. Dillon

Molecular Determinants of Picrotoxin Inhibition of 5-Hydroxytryptamine Type 3 Receptors
J Pharmacol Exp Ther 2005 314: 320-328. Published online April 6, 2005; 10.1124/jpet.104.080325 [Abstract] [Full Text] [PDF]  

Renna Stevens, Dirk Rüsch, Ken Solt, Douglas E. Raines, and Paul A. Davies

Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols
J Pharmacol Exp Ther 2005 314: 338-345. Published online April 14, 2005; 10.1124/jpet.105.085076 [Abstract] [Full Text] [PDF]  

Christian Pifl, Gabor Nagy, Sándor Berényi, Alexandra Kattinger, Harald Reither, and Sándor Antus

Pharmacological Characterization of Ecstasy Synthesis Byproducts with Recombinant Human Monoamine Transporters
J Pharmacol Exp Ther 2005 314: 346-354. Published online April 14, 2005; 10.1124/jpet.105.084426 [Abstract] [Full Text] [PDF]  

Xilong Zhao, Jay Z. Yeh, Vincent L. Salgado, and Toshio Narahashi

Sulfone Metabolite of Fipronil Blocks -Aminobutyric Acid- and Glutamate-Activated Chloride Channels in Mammalian and Insect Neurons
J Pharmacol Exp Ther 2005 314: 363-373. Published online February 8, 2005; 10.1124/jpet.104.077891 [Abstract] [Full Text] [PDF]  

Rachid El Kouhen, Carol S. Surowy, Bruce R. Bianchi, Torben R. Neelands, Heath A. McDonald, Wende Niforatos, Arthur Gomtsyan, Chih-Hung Lee, Prisca Honore, James P. Sullivan, Michael F. Jarvis, and Connie R. Faltynek

A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid
J Pharmacol Exp Ther 2005 314: 400-409. Published online April 18, 2005; 10.1124/jpet.105.084103 [Abstract] [Full Text] [PDF]  

Prisca Honore, Carol T. Wismer, Joe Mikusa, Chang Z. Zhu, Chengmin Zhong, Donna M. Gauvin, Arthur Gomtsyan, Rachid El Kouhen, Chih-Hung Lee, Kennan Marsh, James P. Sullivan, Connie R. Faltynek, and Michael F. Jarvis

A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel Transient Receptor Potential Type V1 Receptor Antagonist, Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats
J Pharmacol Exp Ther 2005 314: 410-421. Published online April 18, 2005; 10.1124/jpet.105.083915 [Abstract] [Full Text] [PDF]  

Shinki Yoshida and Shigeji Matsumoto

Effects of -Dendrotoxin on K⁺ Currents and Action Potentials in Tetrodotoxin-Resistant Adult Rat Trigeminal Ganglion Neurons
J Pharmacol Exp Ther 2005 314: 437-445. Published online April 14, 2005; 10.1124/jpet.105.084988 [Abstract] [Full Text] [PDF]  

Yen-Ping Kuo, Lin Xu, J. Brek Eaton, Lingke Zhao, Jie Wu, and Ronald J. Lukas

Roles for Nicotinic Acetylcholine Receptor Subunit Large Cytoplasmic Loop Sequences in Receptor Expression and Function
J Pharmacol Exp Ther 2005 314: 455-466. Published online April 15, 2005; 10.1124/jpet.105.084954 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Brian E. Reese, Collin Davidson, Melvin L. Billingsley, and Jong Yun

Protein Kinase C Regulates Tumor Necrosis Factor--Induced Stannin Gene Expression
J Pharmacol Exp Ther 2005 314: 61-69. Published online March 29, 2005; 10.1124/jpet.105.084236 [Abstract] [Full Text] [PDF]  

Myong Gyong Lee, Andrew Phimister, Dexter Morin, Alan Buckpitt, and Charles Plopper

In Situ Naphthalene Bioactivation and Nasal Airflow Cause Region-Specific Injury Patterns in the Nasal Mucosa of Rats Exposed to Naphthalene by Inhalation
J Pharmacol Exp Ther 2005 314: 103-110. Published online April 15, 2005; 10.1124/jpet.105.084517 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Pharmacokinetics of Erythromycin in Rabbit Corneas after Single-Dose Infusion: Role of P-Glycoprotein as a Barrier to in Vivo Ocular Drug Absorption"
J Pharmacol Exp Ther 2005 314: 483. [Full Text] [PDF]  

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