PERSPECTIVES IN PHARMACOLOGY:

Rick T. Dobrowsky, Shefali Rouen, and Cuijuan Yu

Altered Neurotrophism in Diabetic Neuropathy: Spelunking the Caves of Peripheral Nerve
J Pharmacol Exp Ther 2005 313: 485-491. Published online December 17, 2004; 10.1124/jpet.104.079921 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Ping Lu, Suresh B. Singh, Brian A. Carr, Yulin Fang, Cathie Dong Xiang, Thomas H. Rushmore, A. David Rodrigues, and Magang Shou

Selective Inhibition of Dog Hepatic CYP2B11 and CYP3A12
J Pharmacol Exp Ther 2005 313: 518-528. Published online January 26, 2005; 10.1124/jpet.104.077651 [Abstract] [Full Text] [PDF]  

Katrin Letschert, Masaharu Komatsu, Johanna Hummel-Eisenbeiss, and Dietrich Keppler

Vectorial Transport of the Peptide CCK-8 by Double-Transfected MDCKII Cells Stably Expressing the Organic Anion Transporter OATP1B3 (OATP8) and the Export Pump ABCC2
J Pharmacol Exp Ther 2005 313: 549-556. Published online January 21, 2005; 10.1124/jpet.104.081224 [Abstract] [Full Text] [PDF]  

Chutima Srimaroeng, Varanuj Chatsudthipong, Amy G. Aslamkhan, and John B. Pritchard

Transport of the Natural Sweetener Stevioside and Its Aglycone Steviol by Human Organic Anion Transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)
J Pharmacol Exp Ther 2005 313: 621-628. Published online January 11, 2005; 10.1124/jpet.104.080366 [Abstract] [Full Text] [PDF]  

Chantal Csajka, Bruno P. Imbimbo, Annalisa Piccinno, Philippe Dostert, and Davide Verotta

Mechanistic Pharmacokinetic and Pharmacodynamic Modeling of CHF3381 (2-[(2,3-Dihydro-1H-inden-2-yl)amino]acetamide Monohydrochloride), a Novel N-Methyl-D-aspartate Antagonist and Monoamine Oxidase-A Inhibitor in Healthy Subjects
J Pharmacol Exp Ther 2005 313: 647-657. Published online January 25, 2005; 10.1124/jpet.104.080457 [Abstract] [Full Text] [PDF]  

Karl B. Scheidweiler, Edward J. Cone, Eric T. Moolchan, and Marilyn A. Huestis

Dose-Related Distribution of Codeine, Cocaine, and Metabolites into Human Hair following Controlled Oral Codeine and Subcutaneous Cocaine Administration
J Pharmacol Exp Ther 2005 313: 909-915. Published online March 2, 2005; 10.1124/jpet.104.082388 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Gianluigi Tanda, Aaron Ebbs, Amy H. Newman, and Jonathan L. Katz

Effects of 4'-Chloro-3-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine
J Pharmacol Exp Ther 2005 313: 613-620. Published online January 28, 2005; 10.1124/jpet.104.080465 [Abstract] [Full Text] [PDF]  

Donna M. Platt, Annemarie Duggan, Roger D. Spealman, James M. Cook, Xiaoyan Li, Wenyuan Yin, and James K. Rowlett

Contribution of ₁GABA_A and ₅GABA_A Receptor Subtypes to the Discriminative Stimulus Effects of Ethanol in Squirrel Monkeys
J Pharmacol Exp Ther 2005 313: 658-667. Published online January 13, 2005; 10.1124/jpet.104.080275 [Abstract] [Full Text] [PDF]  

S. Wee, K. G. Anderson, M. H. Baumann, R. B. Rothman, B. E. Blough, and W. L. Woolverton

Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs
J Pharmacol Exp Ther 2005 313: 848-854. Published online January 26, 2005; 10.1124/jpet.104.080101 [Abstract] [Full Text] [PDF]  

Rajan Radhakrishnan and Kathleen A. Sluka

Acetazolamide, a Carbonic Anhydrase Inhibitor, Reverses Inflammation-Induced Thermal Hyperalgesia in Rats
J Pharmacol Exp Ther 2005 313: 921-927. Published online March 2, 2005; 10.1124/jpet.104.082776 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Jeong Hyun Lee, Goo Taeg Oh, So Youn Park, Jae-Hoon Choi, Jong-Gil Park, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim, Yung Woo Shin, and Ki Whan Hong

Cilostazol Reduces Atherosclerosis by Inhibition of Superoxide and Tumor Necrosis Factor- Formation in Low-Density Lipoprotein Receptor-Null Mice Fed High Cholesterol
J Pharmacol Exp Ther 2005 313: 502-509. Published online February 25, 2005; 10.1124/jpet.104.079780 [Abstract] [Full Text] [PDF]  

Ian Morecroft, Lynn Loughlin, Margaret Nilsen, Janet Colston, Yvonne Dempsie, John Sheward, Anthony Harmar, and Margaret R. MacLean

Functional Interactions between 5-Hydroxytryptamine Receptors and the Serotonin Transporter in Pulmonary Arteries
J Pharmacol Exp Ther 2005 313: 539-548. Published online January 19, 2005; 10.1124/jpet.104.081182 [Abstract] [Full Text] [PDF]  

Wei Li, Tomoko Asagami, Hidetsugu Matsushita, Keun-Ho Lee, and Philip S. Tsao

Rosuvastatin Attenuates Monocyte-Endothelial Cell Interactions and Vascular Free Radical Production in Hypercholesterolemic Mice
J Pharmacol Exp Ther 2005 313: 557-562. Published online January 21, 2005; 10.1124/jpet.104.080002 [Abstract] [Full Text] [PDF]  

Takuji Machida, Paul M. Heerdt, Alicia C. Reid, Ulrich Schäfer, Randi B. Silver, M. Johan Broekman, Aaron J. Marcus, and Roberto Levi

Ectonucleoside Triphosphate Diphosphohydrolase1/CD39, Localized in Neurons of Human and Porcine Heart, Modulates ATP-Induced Norepinephrine Exocytosis
J Pharmacol Exp Ther 2005 313: 570-577. Published online January 12, 2005; 10.1124/jpet.104.081240 [Abstract] [Full Text] [PDF]  

Reeba K. Vikramadithyan, Kumiko Hirata, Hiroaki Yagyu, Yunying Hu, Ayanna Augustus, Shunichi Homma, and Ira J. Goldberg

Peroxisome Proliferator-Activated Receptor Agonists Modulate Heart Function in Transgenic Mice with Lipotoxic Cardiomyopathy
J Pharmacol Exp Ther 2005 313: 586-593. Published online January 25, 2005; 10.1124/jpet.104.080259 [Abstract] [Full Text] [PDF]  

Myoungki Baek and Michael Weiss

Down-Regulation of Na⁺ Pump ₂ Isoform in Isoprenaline-Induced Cardiac Hypertrophy in Rat: Evidence for Increased Receptor Binding Affinity but Reduced Inotropic Potency of Digoxin
J Pharmacol Exp Ther 2005 313: 731-739. Published online January 11, 2005; 10.1124/jpet.104.078345 [Abstract] [Full Text] [PDF]  

Fabio Fusi, Giampietro Sgaragli, and Simona Saponara

Mechanism of Myricetin Stimulation of Vascular L-type Ca²⁺ Current
J Pharmacol Exp Ther 2005 313: 790-797. Published online January 21, 2005; 10.1124/jpet.104.080135 [Abstract] [Full Text] [PDF]  

Gregory R. Ferrier and Susan E. Howlett

Pretreatment with Pinacidil Promotes Arrhythmias in an Isolated Tissue Model of Cardiac Ischemia and Reperfusion
J Pharmacol Exp Ther 2005 313: 823-830. Published online January 25, 2005; 10.1124/jpet.104.081349 [Abstract] [Full Text] [PDF]  

Se-Young Choi, Young-Sang Koh, and Su-Hyun Jo

Inhibition of Human ether-a-go-go-Related Gene K⁺ Channel and I_Kr of Guinea Pig Cardiomyocytes by Antipsychotic Drug Trifluoperazine
J Pharmacol Exp Ther 2005 313: 888-895. Published online February 18, 2005; 10.1124/jpet.104.080853 [Abstract] [Full Text] [PDF]  

Ahila Sivarajah, Michelle C. McDonald, and Christoph Thiemermann

The Cardioprotective Effects of Preconditioning with Endotoxin, but Not Ischemia, Are Abolished by a Peroxisome Proliferator-Activated Receptor- Antagonist
J Pharmacol Exp Ther 2005 313: 896-901. Published online February 25, 2005; 10.1124/jpet.104.080598 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Michelle L. Halls, Courtney P. Bond, Satoko Sudo, Jin Kumagai, Tania Ferraro, Sharon Layfield, Ross A. D. Bathgate, and Roger J. Summers

Multiple Binding Sites Revealed by Interaction of Relaxin Family Peptides with Native and Chimeric Relaxin Family Peptide Receptors 1 and 2 (LGR7 and LGR8)
J Pharmacol Exp Ther 2005 313: 677-687. Published online January 12, 2005; 10.1124/jpet.104.080655 [Abstract] [Full Text] [PDF]  

J. Jakubík, A. Krejcí, and V. Dolezal

Asparagine, Valine, and Threonine in the Third Extracellular Loop of Muscarinic Receptor Have Essential Roles in the Positive Cooperativity of Strychnine-Like Allosteric Modulators
J Pharmacol Exp Ther 2005 313: 688-696. Published online January 12, 2005; 10.1124/jpet.104.080358 [Abstract] [Full Text] [PDF]  

Mauro Cataldi, Vincenzo Lariccia, Agnese Secondo, Gianfranco di Renzo, and Lucio Annunziato

The Antiepileptic Drug Levetiracetam Decreases the Inositol 1,4,5-Trisphosphate-Dependent [Ca²⁺]_i Increase Induced by ATP and Bradykinin in PC12 Cells
J Pharmacol Exp Ther 2005 313: 720-730. Published online January 11, 2005; 10.1124/jpet.104.079327 [Abstract] [Full Text] [PDF]  

Shao-Rui Chen, Jürgen Wess, and Hui-Lin Pan

Functional Activity of the M₂ and M₄ Receptor Subtypes in the Spinal Cord Studied with Muscarinic Acetylcholine Receptor Knockout Mice
J Pharmacol Exp Ther 2005 313: 765-770. Published online January 21, 2005; 10.1124/jpet.104.082537 [Abstract] [Full Text] [PDF]  

Donna L. Dehn, Salmaan H. Inayat-Hussain, and David Ross

RH1 Induces Cellular Damage in an NAD(P)H:Quinone Oxidoreductase 1-Dependent Manner: Relationship between DNA Cross-linking, Cell Cycle Perturbations, and Apoptosis
J Pharmacol Exp Ther 2005 313: 771-779. Published online January 21, 2005; 10.1124/jpet.104.081380 [Abstract] [Full Text] [PDF]  

Marià Pitarque, Cristina Rodríguez-Antona, Mikael Oscarson, and Magnus Ingelman-Sundberg

Transcriptional Regulation of the Human CYP2A6 Gene
J Pharmacol Exp Ther 2005 313: 814-822. Published online January 25, 2005; 10.1124/jpet.104.081570 [Abstract] [Full Text] [PDF]  

Geniece McCollum, Peter C. Keng, J. Christopher States, and Michael J. McCabe, Jr.

Arsenite Delays Progression through Each Cell Cycle Phase and Induces Apoptosis following G₂/M Arrest in U937 Myeloid Leukemia Cells
J Pharmacol Exp Ther 2005 313: 877-887. Published online February 18, 2005; 10.1124/jpet.104.080713 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Yasushi Kurata, Yuji Tabata, Rie Shinei, Yumiko Iizuka, Naomi Takei Masuda, Ken-ichi Kurihara, Tsuneo Okonogi, and Shigeru Hoshiko

Endocrinological Properties of Two Novel Nonsteroidal Progesterone Receptor Modulators, CP8816 and CP8863
J Pharmacol Exp Ther 2005 313: 916-920. Published online March 2, 2005; 10.1124/jpet.104.074146 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Stefano Fiorucci, Carlo Clerici, Elisabetta Antonelli, Stefano Orlandi, Bryan Goodwin, Bahman M. Sadeghpour, Giuseppe Sabatino, Giuseppe Russo, Danilo Castellani, Timothy M. Willson, Mark Pruzanski, Roberto Pellicciari, and Antonio Morelli

Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis
J Pharmacol Exp Ther 2005 313: 604-612. Published online January 11, 2005; 10.1124/jpet.104.079665 [Abstract] [Full Text] [PDF]  

Manish M. Tiwari, Paul L. Prather, and Philip R. Mayeux

Mechanism of Bradykinin-Induced Ca²⁺ Mobilization in Murine Proximal Tubule Epithelial Cells
J Pharmacol Exp Ther 2005 313: 798-805. Published online January 21, 2005; 10.1124/jpet.104.080408 [Abstract] [Full Text] [PDF]  

Digavalli V. Sivarao, Kimberly Newberry, Shaun Langdon, Alicia V. Lee, Piyasena Hewawasam, Mary Jane Plym, Laura Signor, Robert Myers, and Nicholas J. Lodge

Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca²+-Activated K⁺ (Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception
J Pharmacol Exp Ther 2005 313: 840-847. Published online February 8, 2005; 10.1124/jpet.104.079285 [Abstract] [Full Text] [PDF] Erratum  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Charles Kunsch, Jayraz Luchoomun, Xi-lin Chen, Geraldine L. Dodd, Kanika S. Karu, Charles Q. Meng, Elaine M. Marino, Lyn K. Olliff, J. Daniel Piper, Fei-Hua Qiu, James A. Sikorski, Patricia K. Somers, Ki-Ling Suen, Suzanne Thomas, Anne M. Whalen, Martin A. Wasserman, and Cynthia L. Sundell

AGIX-4207 [2-[4-[[1-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic Acid], a Novel Antioxidant and Anti-Inflammatory Compound: Cellular and Biochemical Characterization of Antioxidant Activity and Inhibition of Redox-Sensitive Inflammatory Gene Expression
J Pharmacol Exp Ther 2005 313: 492-501. Published online February 8, 2005; 10.1124/jpet.104.080804 [Abstract] [Full Text] [PDF]  

Tiziana Genovese, Emanuela Mazzon, Rosanna Di Paola, Carmelo Muià, Michael D. Threadgill, Achille P. Caputi, Christoph Thiemermann, and Salvatore Cuzzocrea

Inhibitors of Poly(ADP-Ribose) Polymerase Modulate Signal Transduction Pathways and the Development of Bleomycin-Induced Lung Injury
J Pharmacol Exp Ther 2005 313: 529-538. Published online January 11, 2005; 10.1124/jpet.104.080705 [Abstract] [Full Text] [PDF]  

Jeannie R. Rojas, Ronald P. Taylor, Mark R. Cunningham, Thomas J. Rutkoski, Joseph Vennarini, Haishan Jang, Martin A. Graham, Karel Geboes, Serge D. Rousselle, and Carrie L. Wagner

Formation, Distribution, and Elimination of Infliximab and Anti-Infliximab Immune Complexes in Cynomolgus Monkeys
J Pharmacol Exp Ther 2005 313: 578-585. Published online January 12, 2005; 10.1124/jpet.104.079277 [Abstract] [Full Text] [PDF]  

James A. Snipes, Bela Kis, Gregory S. Shelness, James A. Hewett, and David W. Busija

Cloning and Characterization of Cyclooxygenase-1b (Putative Cyclooxygenase-3) in Rat
J Pharmacol Exp Ther 2005 313: 668-676. Published online January 13, 2005; 10.1124/jpet.104.079533 [Abstract] [Full Text] [PDF]  

Qing-Li Wu, Yun-Feng Fu, Wen-Liang Zhou, Jun-Xia Wang, Yong-Hong Feng, Jing Liu, Jian-Yi Xu, Pei-Lan He, Ru Zhou, Wei Tang, Gui-Feng Wang, Yu Zhou, Yi-Fu Yang, Jian Ding, Xiao-Yu Li, Xiao-Ru Chen, Chong Yuan, Brian R. Lawson, and Jian-Ping Zuo

Inhibition of S-Adenosyl-L-homocysteine Hydrolase Induces Immunosuppression
J Pharmacol Exp Ther 2005 313: 705-711. Published online January 7, 2005; 10.1124/jpet.104.080416 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Kerry A. O'Connor, Linda J. Porrino, Huw M. L. Davies, and Steven R. Childers

Time-Dependent Changes in Receptor/G-Protein Coupling in Rat Brain following Chronic Monoamine Transporter Blockade
J Pharmacol Exp Ther 2005 313: 510-517. Published online January 11, 2005; 10.1124/jpet.104.078451 [Abstract] [Full Text] [PDF]  

Bo Hu and Fang Zheng

Molecular Determinants of Glycine-Independent Desensitization of NR1/NR2A Receptors
J Pharmacol Exp Ther 2005 313: 563-569. Published online January 13, 2005; 10.1124/jpet.104.080168 [Abstract] [Full Text] [PDF]  

Marion Wittmann, Michael J. Marino, Darrell A. Henze, Guy R. Seabrook, and P. Jeffrey Conn

Clozapine Potentiation of N-Methyl-D-aspartate Receptor Currents in the Nucleus Accumbens: Role of NR2B and Protein Kinase A/Src Kinases
J Pharmacol Exp Ther 2005 313: 594-603. Published online January 19, 2005; 10.1124/jpet.104.080200 [Abstract] [Full Text] [PDF]  

Hong-Mei Zhang, De-Pei Li, Shao-Rui Chen, and Hui-Lin Pan

M₂, M₃, and M₄ Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons
J Pharmacol Exp Ther 2005 313: 697-704. Published online January 7, 2005; 10.1124/jpet.104.079939 [Abstract] [Full Text] [PDF]  

Jamal Temsamani, Cécile Bonnafous, Christophe Rousselle, Yannik Fraisse, Philippe Clair, Luc-André Granier, Anthony R. Rees, Michel Kaczorek, and Jean-Michel Scherrmann

Improved Brain Uptake and Pharmacological Activity Profile of Morphine-6-Glucuronide Using a Peptide Vector-Mediated Strategy
J Pharmacol Exp Ther 2005 313: 712-719. Published online January 12, 2005; 10.1124/jpet.104.081000 [Abstract] [Full Text] [PDF]  

Manickavasagom Alkondon and Edson X. Albuquerque

Nicotinic Receptor Subtypes in Rat Hippocampal Slices Are Differentially Sensitive to Desensitization and Early in Vivo Functional Up-Regulation by Nicotine and to Block by Bupropion
J Pharmacol Exp Ther 2005 313: 740-750. Published online January 12, 2005; 10.1124/jpet.104.081232 [Abstract] [Full Text] [PDF]  

Christian Grommes, Gary E. Landreth, Uwe Schlegel, and Michael T. Heneka

The Nonthiazolidinedione Tyrosine-Based Peroxisome Proliferator-Activated Receptor Ligand GW7845 Induces Apoptosis and Limits Migration and Invasion of Rat and Human Glioma Cells
J Pharmacol Exp Ther 2005 313: 806-813. Published online January 21, 2005; 10.1124/jpet.104.078972 [Abstract] [Full Text] [PDF]  

Shigeyuki Chaki, Takeo Funakoshi, Shiho Hirota-Okuno, Mariko Nishiguchi, Toshiharu Shimazaki, Michihiko Iijima, Andrew J. Grottick, Kosuke Kanuma, Katsunori Omodera, Yoshinori Sekiguchi, Shigeru Okuyama, Thuy-Anh Tran, Graeme Semple, and William Thomsen

Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists
J Pharmacol Exp Ther 2005 313: 831-839. Published online January 26, 2005; 10.1124/jpet.104.081711 [Abstract] [Full Text] [PDF]  

John Dunlop, Annmarie L. Sabb, Hossein Mazandarani, Jean Zhang, Sachin Kalgaonker, Eugenia Shukhina, Stacey Sukoff, Robert L. Vogel, Gary Stack, Lee Schechter, Boyd L. Harrison, and Sharon Rosenzweig-Lipson

WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-Octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a Novel 5-Hydroxytryptamine 2C Receptor-Selective Agonist with Anorectic Activity
J Pharmacol Exp Ther 2005 313: 862-869. Published online February 10, 2005; 10.1124/jpet.104.075382 [Abstract] [Full Text] [PDF] Data Supplement  

David M. Thomas and Donald M. Kuhn

Cyclooxygenase-2 Is an Obligatory Factor in Methamphetamine-Induced Neurotoxicity
J Pharmacol Exp Ther 2005 313: 870-876. Published online February 17, 2005; 10.1124/jpet.104.080242 [Abstract] [Full Text] [PDF]  

Jonathan D. Best, Mark T. Jay, Franklin Otu, Jerome Ma, Alan Nadin, Semantha Ellis, Huw D. Lewis, Christine Pattison, Michael Reilly, Timothy Harrison, Mark S. Shearman, Toni L. Williamson, and John R. Atack

Quantitative Measurement of Changes in Amyloid-(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the -Secretase Inhibitor LY-411575 [N²-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N¹-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide]
J Pharmacol Exp Ther 2005 313: 902-908. Published online March 2, 2005; 10.1124/jpet.104.081174 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Daniel E. Rusyniak, Stephany L. Tandy, S. K. Hekmatyar, Edward Mills, David J. Smith, Navin Bansal, Darcy MacLellan, Mary-Ellen Harper, and Jon E. Sprague

The Role of Mitochondrial Uncoupling in 3,4-Methylenedioxymethamphetamine-Mediated Skeletal Muscle Hyperthermia and Rhabdomyolysis
J Pharmacol Exp Ther 2005 313: 629-639. Published online January 11, 2005; 10.1124/jpet.104.079236 [Abstract] [Full Text] [PDF]  

Stefan S. De Buck, Patrick Augustijns, and Claude P. Muller

Specific Antibody Modulates Absorptive Transport and Metabolic Activation of Benzo[a]pyrene across Caco-2 Monolayers
J Pharmacol Exp Ther 2005 313: 640-646. Published online January 21, 2005; 10.1124/jpet.104.081034 [Abstract] [Full Text] [PDF]  

Yukun Yuan and William D. Atchison

Methylmercury Induces a Spontaneous, Transient Slow Inward Chloride Current in Purkinje Cells of Rat Cerebellar Slices
J Pharmacol Exp Ther 2005 313: 751-764. Published online February 1, 2005; 10.1124/jpet.104.080721 [Abstract] [Full Text] [PDF]  

Patricia Macanas-Pirard, Nik-Soriani Yaacob, Pauline C. Lee, Julie C. Holder, Richard H. Hinton, and George E. N. Kass

Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells
J Pharmacol Exp Ther 2005 313: 780-789. Published online January 21, 2005; 10.1124/jpet.104.081364 [Abstract] [Full Text] [PDF]  

Sharda P. Singh, Tao Chen, Ling Chen, Nan Mei, Eric McLain, Victor Samokyszyn, John J. Thaden, Martha M. Moore, and Piotr Zimniak

Mutagenic Effects of 4-Hydroxynonenal Triacetate, a Chemically Protected Form of the Lipid Peroxidation Product 4-Hydroxynonenal, as Assayed in L5178Y/Tk⁺/– Mouse Lymphoma Cells
J Pharmacol Exp Ther 2005 313: 855-861. Published online February 8, 2005; 10.1124/jpet.104.080754 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Pradeep Banerjee, Gary Samoriski, and Sandeep Gupta

Comments on "Memantine Blocks 7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons"
J Pharmacol Exp Ther 2005 313: 928-929. [Full Text] [PDF]  

Yasco Aracava, Edna F. R. Pereira, Alfred Maelicke, and Edson X. Albuquerque

Response: Comments on "Memantine Blocks 7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons"
J Pharmacol Exp Ther 2005 313: 930-933. [Full Text] [PDF]  

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