PERSPECTIVES IN PHARMACOLOGY:

Xuezhong G. He, Guillermo Gerona-Navarro, and Samie R. Jaffrey

Ligand Discovery Using Small Molecule Microarrays
J Pharmacol Exp Ther 2005 313: 1-7. Published online November 10, 2004; 10.1124/jpet.104.076943 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Hsia-lien Lin, Ute M. Kent, and Paul F. Hollenberg

The Grapefruit Juice Effect Is Not Limited to Cytochrome P450 (P450) 3A4: Evidence for Bergamottin-Dependent Inactivation, Heme Destruction, and Covalent Binding to Protein in P450s 2B6 and 3A5
J Pharmacol Exp Ther 2005 313: 154-164. Published online December 17, 2004; 10.1124/jpet.104.079608 [Abstract] [Full Text] [PDF]  

Jim J. Xiao, Amy B. Foraker, Peter W. Swaan, Shujun Liu, Ying Huang, Zunyan Dai, Jiyun Chen, Wolfgang Sadée, John Byrd, Guido Marcucci, and Kenneth K. Chan

Efflux of Depsipeptide FK228 (FR901228, NSC-630176) Is Mediated by P-Glycoprotein and Multidrug Resistance-Associated Protein 1
J Pharmacol Exp Ther 2005 313: 268-276. Published online January 5, 2005; 10.1124/jpet.104.072033 [Abstract] [Full Text] [PDF]  

Su-Jun Lee, Douglas A. Bell, Sherry J. Coulter, Burhan Ghanayem, and Joyce A. Goldstein

Recombinant CYP3A4^*17 Is Defective in Metabolizing the Hypertensive Drug Nifedipine, and the CYP3A4^*17 Allele May Occur on the Same Chromosome as CYP3A5^*3, Representing a New Putative Defective CYP3A Haplotype
J Pharmacol Exp Ther 2005 313: 302-309. Published online January 5, 2005; 10.1124/jpet.104.078758 [Abstract] [Full Text] [PDF]  

Danielle N. McLennan, Christopher J. H. Porter, Glenn A. Edwards, Steven W. Martin, Anne C. Heatherington, and Susan A. Charman

Lymphatic Absorption Is the Primary Contributor to the Systemic Availability of Epoetin Alfa following Subcutaneous Administration to Sheep
J Pharmacol Exp Ther 2005 313: 345-351. Published online December 3, 2004; 10.1124/jpet.104.078790 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Zachary A. Rodd, Richard L. Bell, Kelly A. Kuc, Ying Zhang, James M. Murphy, and William J. McBride

Intracranial Self-Administration of Cocaine within the Posterior Ventral Tegmental Area of Wistar Rats: Evidence for Involvement of Serotonin-3 Receptors and Dopamine Neurons
J Pharmacol Exp Ther 2005 313: 134-145. Published online January 13, 2005; 10.1124/jpet.104.075952 [Abstract] [Full Text] [PDF]  

Charles D. Cook and Michael D. Nickerson

Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund's Adjuvant-Induced Arthritic Male and Female Rats
J Pharmacol Exp Ther 2005 313: 449-459. Published online December 17, 2004; 10.1124/jpet.104.077792 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Adviye Ergul, Jeanette Schultz Johansen, Catherine Strømhaug, Alex K. Harris, Jimmie Hutchinson, Amany Tawfik, Ali Rahimi, Edward Rhim, Bryan Wells, R. William Caldwell, and Mark P. Anstadt

Vascular Dysfunction of Venous Bypass Conduits Is Mediated by Reactive Oxygen Species in Diabetes: Role of Endothelin-1
J Pharmacol Exp Ther 2005 313: 70-77. Published online December 17, 2004; 10.1124/jpet.104.078105 [Abstract] [Full Text] [PDF]  

N. D. Vaziri, Y. Ding, Z. Ni, and C. H. Barton

Bradykinin Down-Regulates, Whereas Arginine Analogs Up-Regulates, Endothelial Nitric-Oxide Synthase Expression in Coronary Endothelial Cells
J Pharmacol Exp Ther 2005 313: 121-126. Published online January 7, 2005; 10.1124/jpet.104.076497 [Abstract] [Full Text] [PDF]  

Davide Pau, Antony J. Workman, Kathleen A. Kane, and Andrew C. Rankin

Electrophysiological Effects of Prucalopride, a Novel Enterokinetic Agent, on Isolated Atrial Myocytes from Patients Treated with -Adrenoceptor Antagonists
J Pharmacol Exp Ther 2005 313: 146-153. Published online January 11, 2005; 10.1124/jpet.104.076869 [Abstract] [Full Text] [PDF]  

Marcella Rocchetti, Alessandra Besana, Gaspare Mostacciuolo, Rosella Micheletti, Patrizia Ferrari, Sandor Sarkozi, Csaba Szegedi, Istvan Jona, and Antonio Zaza

Modulation of Sarcoplasmic Reticulum Function by Na⁺/K⁺ Pump Inhibitors with Different Toxicity: Digoxin and PST2744 [(E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride]
J Pharmacol Exp Ther 2005 313: 207-215. Published online December 2, 2004; 10.1124/jpet.104.077933 [Abstract] [Full Text] [PDF] Data Supplement  

Julien Hanson, Stephanie Rolin, Denis Reynaud, Na Qiao, Leanne P. Kelley, Helen M. Reid, François Valentin, John Tippins, B. Therese Kinsella, Bernard Masereel, Cecil Pace-Asciak, Bernard Pirotte, and Jean-Michel Dogné

In Vitro and in Vivo Pharmacological Characterization of BM-613 [N-n-Pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a Novel Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist
J Pharmacol Exp Ther 2005 313: 293-301. Published online December 30, 2004; 10.1124/jpet.104.079301 [Abstract] [Full Text] [PDF]  

R. Miquel, R. Gisbert, E. Serna, F. Perez-Vizcaino, E. Anselmi, M. A. Noguera, M. D. Ivorra, and M. P. D'Ocon

Acute and Chronic Captopril, but Not Prazosin or Nifedipine, Normalize Alterations in Adrenergic Intracellular Ca²⁺ Handling Observed in the Mesenteric Arterial Tree of Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2005 313: 359-367. Published online December 22, 2004; 10.1124/jpet.104.078725 [Abstract] [Full Text] [PDF]  

Nicholas A. Flavahan

Phenylpropanolamine Constricts Mouse and Human Blood Vessels by Preferentially Activating 2-Adrenoceptors
J Pharmacol Exp Ther 2005 313: 432-439. Published online December 17, 2004; 10.1124/jpet.104.076653 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Michelle A. Uberti, Chris Hague, Heide Oller, Kenneth P. Minneman, and Randy A. Hall

Heterodimerization with ₂-Adrenergic Receptors Promotes Surface Expression and Functional Activity of _1D-Adrenergic Receptors
J Pharmacol Exp Ther 2005 313: 16-23. Published online December 22, 2004; 10.1124/jpet.104.079541 [Abstract] [Full Text] [PDF]  

James Varani, Narasimharao Bhagavathula, Kamalakar C. Nerusu, Hilary Sherzer, Kevin Fay, Anthony E. Boitano, Gary D. Glick, Kent Johnson, Sewon Kang, and Anthony W. Opipari, Jr.

A Novel Benzodiazepine Selectively Inhibits Keratinocyte Proliferation and Reduces Retinoid-Induced Epidermal Hyperplasia in Organ-Cultured Human Skin
J Pharmacol Exp Ther 2005 313: 56-63. Published online December 2, 2004; 10.1124/jpet.104.075929 [Abstract] [Full Text] [PDF]  

Evi Kostenis, Lene Martini, James Ellis, Maria Waldhoer, Arne Heydorn, Mette M. Rosenkilde, Pia K. Norregaard, Rasmus Jorgensen, Jennifer L. Whistler, and Graeme Milligan

A Highly Conserved Glycine within Linker I and the Extreme C Terminus of G Protein Subunits Interact Cooperatively in Switching G Protein-Coupled Receptor-to-Effector Specificity
J Pharmacol Exp Ther 2005 313: 78-87. Published online December 22, 2004; 10.1124/jpet.104.080424 [Abstract] [Full Text] [PDF]  

Wen-Cheng Chung and John C. Kermode

Suramin Disrupts Receptor-G Protein Coupling by Blocking Association of G Protein and Subunits
J Pharmacol Exp Ther 2005 313: 191-198. Published online December 30, 2004; 10.1124/jpet.104.078311 [Abstract] [Full Text] [PDF]  

Patricia A. Claude-Geppert, Jiahui Liu, Jonathan Solberg, Laurie J. Erickson-Herbrandson, Horace H. Loh, and Ping-Yee Law

Antagonist Efficacy in MORS196L Mutant Is Affected by the Interaction between Transmembrane Domains of the Opioid Receptor
J Pharmacol Exp Ther 2005 313: 216-226. Published online December 3, 2004; 10.1124/jpet.104.076505 [Abstract] [Full Text] [PDF]  

Svetlana Tertyshnikova, Ronald J. Knox, Mary Jane Plym, George Thalody, Corinne Griffin, Torben Neelands, David G. Harden, Laura Signor, David Weaver, Robert A. Myers, and Nicholas J. Lodge

BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties
J Pharmacol Exp Ther 2005 313: 250-259. Published online December 17, 2004; 10.1124/jpet.104.078592 [Abstract] [Full Text] [PDF]  

Bruce W. Ennis, Kimberly E. Fultz, Kent A. Smith, John K. Westwick, Dan Zhu, Michael Boluro-Ajayi, Graham K. Bilter, and Bernd Stein

Inhibition of Tumor Growth, Angiogenesis, and Tumor Cell Proliferation by a Small Molecule Inhibitor of c-Jun N-terminal Kinase
J Pharmacol Exp Ther 2005 313: 325-332. Published online December 30, 2004; 10.1124/jpet.104.078873 [Abstract] [Full Text] [PDF]  

Ya-Ling Hsu, Po-Lin Kuo, Liang-Tzung Lin, and Chun-Ching Lin

Asiatic Acid, a Triterpene, Induces Apoptosis and Cell Cycle Arrest through Activation of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways in Human Breast Cancer Cells
J Pharmacol Exp Ther 2005 313: 333-344. Published online December 30, 2004; 10.1124/jpet.104.078808 [Abstract] [Full Text] [PDF]  

Frederick J. Ehlert, Michael T. Griffin, Diane M. Abe, Tran H. Vo, Makoto M. Taketo, Toshiya Manabe, and Minoru Matsui

The M₂ Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder
J Pharmacol Exp Ther 2005 313: 368-378. Published online December 17, 2004; 10.1124/jpet.104.077909 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Maria J. Abad-Merin, Nuria Cortés, Isabel Masip, Enrique Pérez-Payá, José A. Ferragut, Angel Messeguer, and Antonio Ferrer-Montiel

Trimers of N-Alkylglycines Are Potent Modulators of the Multidrug Resistance Phenotype
J Pharmacol Exp Ther 2005 313: 112-120. Published online January 11, 2005; 10.1124/jpet.104.078014 [Abstract] [Full Text] [PDF] Data Supplement  

F. Frausin, V. Scarcia, M. Cocchietto, A. Furlani, B. Serli, E. Alessio, and G. Sava

Free Exchange across Cells, and Echistatin-Sensitive Membrane Target for the Metastasis Inhibitor NAMI-A (Imidazolium trans-Imidazole Dimethyl Sulfoxide Tetrachlororuthenate) on KB Tumor Cells
J Pharmacol Exp Ther 2005 313: 227-233. Published online December 3, 2004; 10.1124/jpet.104.078352 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Michael F. Ethier, Erika Cappelluti, and J. Mark Madison

Mechanisms of Interleukin-4 Effects on Calcium Signaling in Airway Smooth Muscle Cells
J Pharmacol Exp Ther 2005 313: 127-133. Published online January 5, 2005; 10.1124/jpet.104.079343 [Abstract] [Full Text] [PDF]  

C. Sauvant, H. Holzinger, and M. Gekle

Proximal Tubular Toxicity of Ochratoxin A Is Amplified by Simultaneous Inhibition of the Extracellular Signal-Regulated Kinases 1/2
J Pharmacol Exp Ther 2005 313: 234-241. Published online December 30, 2004; 10.1124/jpet.104.079475 [Abstract] [Full Text] [PDF]  

Elfaridah P. Frazier, Marie-Jeanne Mathy, Stephan L. M. Peters, and Martin C. Michel

Does Cyclic AMP Mediate Rat Urinary Bladder Relaxation by Isoproterenol?
J Pharmacol Exp Ther 2005 313: 260-267. Published online December 2, 2004; 10.1124/jpet.104.077768 [Abstract] [Full Text] [PDF]  

Peter J. Oldenburg and S. Jamal Mustafa

Involvement of Mast Cells in Adenosine-Mediated Bronchoconstriction and Inflammation in an Allergic Mouse Model
J Pharmacol Exp Ther 2005 313: 319-324. Published online December 30, 2004; 10.1124/jpet.104.071720 [Abstract] [Full Text] [PDF]  

Shuang Mei, Wei Yao, Yuanjue Zhu, and Jinyuan Zhao

Protection of Pirfenidone against an Early Phase of Oleic Acid-Induced Acute Lung Injury in Rats
J Pharmacol Exp Ther 2005 313: 379-388. Published online December 17, 2004; 10.1124/jpet.104.078030 [Abstract] [Full Text] [PDF] Data Supplement  

Timo Rieg, Hannah Steigele, Jurgen Schnermann, Kerstin Richter, Hartmut Osswald, and Volker Vallon

Requirement of Intact Adenosine A₁ Receptors for the Diuretic and Natriuretic Action of the Methylxanthines Theophylline and Caffeine
J Pharmacol Exp Ther 2005 313: 403-409. Published online December 8, 2004; 10.1124/jpet.104.080432 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Gaoyun Yang, Li Li, Amy Volk, Eva Emmell, Ted Petley, Jill Giles-Komar, Patricia Rafferty, Mani Lakshminarayanan, Don E. Griswold, Peter J. Bugelski, and Anuk M. Das

Therapeutic Dosing with Anti-Interleukin-13 Monoclonal Antibody Inhibits Asthma Progression in Mice
J Pharmacol Exp Ther 2005 313: 8-15. Published online January 11, 2005; 10.1124/jpet.104.076133 [Abstract] [Full Text] [PDF]  

Tamaki Yamada, Atsushi Kuno, Kumiko Ogawa, Mingxi Tang, Kazuhiko Masuda, Soichi Nakamura, Tomoaki Ando, Tetsu Okamoto, Hirotaka Ohara, Tomoyuki Nomura, Takashi Joh, Tomoyuki Shirai, and Makoto Itoh

Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and an Angiotensin II Receptor Blocker Synergistically Suppresses Chronic Pancreatitis in Rats
J Pharmacol Exp Ther 2005 313: 36-45. Published online December 17, 2004; 10.1124/jpet.104.077883 [Abstract] [Full Text] [PDF]  

Wagdi Almishri, Chantal Cossette, Joshua Rokach, James G. Martin, Qutayba Hamid, and William S. Powell

Effects of Prostaglandin D₂, 15-Deoxy-^12,14-prostaglandin J₂, and Selective DP₁ and DP₂ Receptor Agonists on Pulmonary Infiltration of Eosinophils in Brown Norway Rats
J Pharmacol Exp Ther 2005 313: 64-69. Published online December 8, 2004; 10.1124/jpet.104.079079 [Abstract] [Full Text] [PDF]  

Jun Katada, Hitomi Saito, and Akira Ohashi

Significance of Cyclooxygenase-2 Induced via p38 Mitogen-Activated Protein Kinase in Mechanical Stimulus-Induced Peritoneal Adhesion in Mice
J Pharmacol Exp Ther 2005 313: 286-292. Published online December 2, 2004; 10.1124/jpet.104.078717 [Abstract] [Full Text] [PDF]  

Carla F. Franco-Penteado, Ivani A. De Souza, Enilton A. Camargo, Simone A. Teixeira, Marcelo N. Muscara, Gilberto De Nucci, and Edson Antunes

Mechanisms Involved in the Enhancement of Allergic Airways Neutrophil Influx by Permanent C-Fiber Degeneration in Rats
J Pharmacol Exp Ther 2005 313: 440-448. Published online December 3, 2004; 10.1124/jpet.104.078147 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Jian-Hong Peng, John D. Fryer, Raymond S. Hurst, Katherine M. Schroeder, Andrew A. George, Steven Morrissy, Vincent E. Groppi, Sherry S. Leonard, and Ronald J. Lukas

High-Affinity Epibatidine Binding of Functional, Human 7-Nicotinic Acetylcholine Receptors Stably and Heterologously Expressed de Novo in Human SH-EP1 Cells
J Pharmacol Exp Ther 2005 313: 24-35. Published online December 8, 2004; 10.1124/jpet.104.079004 [Abstract] [Full Text] [PDF]  

Sun Hee Kim, Seok Joon Won, Xiao Ou Mao, Kunlin Jin, and David A. Greenberg

Involvement of Protein Kinase A in Cannabinoid Receptor-Mediated Protection from Oxidative Neuronal Injury
J Pharmacol Exp Ther 2005 313: 88-94. Published online December 30, 2004; 10.1124/jpet.104.079509 [Abstract] [Full Text] [PDF]  

Timothy A. Esbenshade, Gerard B. Fox, Kathleen M. Krueger, Thomas R. Miller, Chae Hee Kang, Lynne I. Denny, David G. Witte, Betty B. Yao, Liping Pan, Jill Wetter, Kennan Marsh, Youssef L. Bennani, Marlon D. Cowart, James P. Sullivan, and Arthur A. Hancock

Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H₃ Receptor Antagonist with Drug-Like Properties
J Pharmacol Exp Ther 2005 313: 165-175. Published online December 17, 2004; 10.1124/jpet.104.078303 [Abstract] [Full Text] [PDF]  

Gerard B. Fox, Timothy A. Esbenshade, Jia Bao Pan, Richard J. Radek, Kathleen M. Krueger, Betty B. Yao, Kaitlin E. Browman, Michael J. Buckley, Michael E. Ballard, Victoria A. Komater, Holly Miner, Min Zhang, Ramin Faghih, Lynne E. Rueter, R. Scott Bitner, Karla U. Drescher, Jill Wetter, Kennan Marsh, Martine Lemaire, Roger D. Porsolt, Youssef L. Bennani, James P. Sullivan, Marlon D. Cowart, Michael W. Decker, and Arthur A. Hancock

Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H₃ Receptor Antagonist
J Pharmacol Exp Ther 2005 313: 176-190. Published online December 17, 2004; 10.1124/jpet.104.078402 [Abstract] [Full Text] [PDF]  

Gene G. Kinney, Julie A. O'Brien, Wei Lemaire, Maryann Burno, Denise J. Bickel, Michelle K. Clements, Tsing-Bau Chen, David D. Wisnoski, Craig W. Lindsley, Philip R. Tiller, Sheri Smith, Marlene A. Jacobson, Cyrille Sur, Mark E. Duggan, Douglas J. Pettibone, P. Jeffrey Conn, and David L. Williams, Jr.

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
J Pharmacol Exp Ther 2005 313: 199-206. Published online December 17, 2004; 10.1124/jpet.104.079244 [Abstract] [Full Text] [PDF]  

Anna Pittaluga, Marco Feligioni, Fabio Longordo, Marica Arvigo, and Maurizio Raiteri

Somatostatin-Induced Activation and Up-Regulation of N-Methyl-D-aspartate Receptor Function: Mediation through Calmodulin-Dependent Protein Kinase II, Phospholipase C, Protein Kinase C, and Tyrosine Kinase in Hippocampal Noradrenergic Nerve Endings
J Pharmacol Exp Ther 2005 313: 242-249. Published online December 17, 2004; 10.1124/jpet.104.079590 [Abstract] [Full Text] [PDF]  

Yan-Fang Xia, Markus Kessler, and Amy C. Arai

Positive -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Modulators Have Different Impact on Synaptic Transmission in the Thalamus and Hippocampus
J Pharmacol Exp Ther 2005 313: 277-285. Published online December 30, 2004; 10.1124/jpet.104.078196 [Abstract] [Full Text] [PDF]  

Michel F. Otuki, Juliano Ferreira, Fabiana V. Lima, Cristiane Meyre-Silva, Ângela Malheiros, Luciane A. Muller, Graziela S. Cani, Adair R. S. Santos, Rosendo A. Yunes, and João B. Calixto

Antinociceptive Properties of Mixture of -Amyrin and -Amyrin Triterpenes: Evidence for Participation of Protein Kinase C and Protein Kinase A Pathways
J Pharmacol Exp Ther 2005 313: 310-318. Published online December 30, 2004; 10.1124/jpet.104.071779 [Abstract] [Full Text] [PDF]  

Darren Fegley, Silvana Gaetani, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, and Daniele Piomelli

Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3'-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation
J Pharmacol Exp Ther 2005 313: 352-358. Published online December 3, 2004; 10.1124/jpet.104.078980 [Abstract] [Full Text] [PDF]  

Giovanni Cucchiaro, Nayla Chaijale, and Kathryn G. Commons

The Dorsal Raphe Nucleus as a Site of Action of the Antinociceptive and Behavioral Effects of the 4 Nicotinic Receptor Agonist Epibatidine
J Pharmacol Exp Ther 2005 313: 389-394. Published online December 17, 2004; 10.1124/jpet.104.079368 [Abstract] [Full Text] [PDF]  

Margaret J. Bradbury, Una Campbell, Darlene Giracello, Deborah Chapman, Chris King, Lida Tehrani, Nicholas D. P. Cosford, Jeff Anderson, Mark A. Varney, and Alison M. Strack

Metabotropic Glutamate Receptor mGlu5 Is a Mediator of Appetite and Energy Balance in Rats and Mice
J Pharmacol Exp Ther 2005 313: 395-402. Published online December 8, 2004; 10.1124/jpet.104.076406 [Abstract] [Full Text] [PDF]  

P. Tryoen-Tóth, F. M. Décaillot, D. Filliol, K. Befort, L. H. Lazarus, P. W. Schiller, H. Schmidhammer, and B. L. Kieffer

Inverse Agonism and Neutral Antagonism at Wild-Type and Constitutively Active Mutant Delta Opioid Receptors
J Pharmacol Exp Ther 2005 313: 410-421. Published online December 8, 2004; 10.1124/jpet.104.077321 [Abstract] [Full Text] [PDF]  

Jérôme Maheux, Isabelle Éthier, Claude Rouillard, and Daniel Lévesque

Induction Patterns of Transcription Factors of the Nur Family (Nurr1, Nur77, and Nor-1) by Typical and Atypical Antipsychotics in the Mouse Brain: Implication for Their Mechanism of Action
J Pharmacol Exp Ther 2005 313: 460-473. Published online December 22, 2004; 10.1124/jpet.104.080184 [Abstract] [Full Text] [PDF]  

Narender R. Gavva, Rami Tamir, Yusheng Qu, Lana Klionsky, T. J. Zhang, David Immke, Judy Wang, Dawn Zhu, Todd W. Vanderah, Frank Porreca, Elizabeth M. Doherty, Mark H. Norman, Kenneth D. Wild, Anthony W. Bannon, Jean-Claude Louis, and James J. S. Treanor

AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties
J Pharmacol Exp Ther 2005 313: 474-484. Published online December 22, 2004; 10.1124/jpet.104.079855 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Calivarathan Latchoumycandane, Vellareddy Anantharam, Masashi Kitazawa, Yongjie Yang, Arthi Kanthasamy, and Anumantha G. Kanthasamy

Protein Kinase C Is a Key Downstream Mediator of Manganese-Induced Apoptosis in Dopaminergic Neuronal Cells
J Pharmacol Exp Ther 2005 313: 46-55. Published online December 17, 2004; 10.1124/jpet.104.078469 [Abstract] [Full Text] [PDF]  

Erik J. Martin and Poh-Gek Forkert

1,1-Dichloroethylene-Induced Mitochondrial Damage Precedes Apoptotic Cell Death of Bronchiolar Epithelial Cells in Murine Lung
J Pharmacol Exp Ther 2005 313: 95-103. Published online December 30, 2004; 10.1124/jpet.104.079392 [Abstract] [Full Text] [PDF]  

Odile Sergent, Manuella Pereira, Corinne Belhomme, Martine Chevanne, Laurence Huc, and Dominique Lagadic-Gossmann

Role for Membrane Fluidity in Ethanol-Induced Oxidative Stress of Primary Rat Hepatocytes
J Pharmacol Exp Ther 2005 313: 104-111. Published online January 5, 2005; 10.1124/jpet.104.078634 [Abstract] [Full Text] [PDF]  

Douglas C. Jones, Christine Duvauchelle, Aiko Ikegami, Christopher M. Olsen, Serrine S. Lau, Rafael de la Torre, and Terrence J. Monks

Serotonergic Neurotoxic Metabolites of Ecstasy Identified in Rat Brain
J Pharmacol Exp Ther 2005 313: 422-431. Published online January 5, 2005; 10.1124/jpet.104.077628 [Abstract] [Full Text] [PDF]  

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