PERSPECTIVES IN PHARMACOLOGY:

Bernard Le Foll and Steven R. Goldberg

Cannabinoid CB₁ Receptor Antagonists as Promising New Medications for Drug Dependence
J Pharmacol Exp Ther 2005 312: 875-883. Published online November 3, 2004; 10.1124/jpet.104.077974 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Ann-Charlotte Egnell, J. Brian Houston, and C. Scott Boyer

Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling
J Pharmacol Exp Ther 2005 312: 926-937. Published online November 30, 2004; 10.1124/jpet.104.078519 [Abstract] [Full Text] [PDF]  

Sean C. Semple, Troy O. Harasym, Kathy A. Clow, Steven M. Ansell, Sandra K. Klimuk, and Michael J. Hope

Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid
J Pharmacol Exp Ther 2005 312: 1020-1026. Published online November 3, 2004; 10.1124/jpet.104.078113 [Abstract] [Full Text] [PDF]  

Yan-Fei Xin, Xiang-Jun Zhou, Xi Cheng, and Yong-Xiang Wang

Renal D-Amino Acid Oxidase Mediates Chiral Inversion of N^G-Nitro-D-arginine
J Pharmacol Exp Ther 2005 312: 1090-1096. Published online October 20, 2004; 10.1124/jpet.104.077123 [Abstract] [Full Text] [PDF]  

Mary F. Paine, Anne B. Criss, and Paul B. Watkins

Two Major Grapefruit Juice Components Differ in Time to Onset of Intestinal CYP3A4 Inhibition
J Pharmacol Exp Ther 2005 312: 1151-1160. Published online October 14, 2004; 10.1124/jpet.104.076836 [Abstract] [Full Text] [PDF]  

Seonghee Park and Patrick J. Sinko

P-Glycoprotein and Mutlidrug Resistance-Associated Proteins Limit the Brain Uptake of Saquinavir in Mice
J Pharmacol Exp Ther 2005 312: 1249-1256. Published online November 4, 2004; 10.1124/jpet.104.076216 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Carrie K. Jones, Elizabeth Lutz Eberle, David B. Shaw, David L. McKinzie, and Harlan E. Shannon

Pharmacologic Interactions between the Muscarinic Cholinergic and Dopaminergic Systems in the Modulation of Prepulse Inhibition in Rats
J Pharmacol Exp Ther 2005 312: 1055-1063. Published online December 1, 2004; 10.1124/jpet.104.075887 [Abstract] [Full Text] [PDF]  

E. L. Lane, S. Cheetham, and P. Jenner

Dopamine Uptake Inhibitor-Induced Rotation in 6-Hydroxydopamine-Lesioned Rats Involves Both D₁ and D₂ Receptors but Is Modulated through 5-Hydroxytryptamine and Noradrenaline Receptors
J Pharmacol Exp Ther 2005 312: 1124-1131. Published online November 12, 2004; 10.1124/jpet.104.076554 [Abstract] [Full Text] [PDF]  

Sharon Bingham, Paul J. Beswick, Chas Bountra, Terry Brown, Ian B. Campbell, Iain P. Chessell, Nick Clayton, Sue D. Collins, Philip T. Davey, Helen Goodland, Norman Gray, Claudine Haslam, Jonathan P. Hatcher, A. Jacqueline Hunter, Fiona Lucas, Graham Murkitt, Alan Naylor, Elizabeth Pickup, Becky Sargent, Scott G. Summerfield, Alexander Stevens, Sharon C. Stratton, and Joanne Wiseman

The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization
J Pharmacol Exp Ther 2005 312: 1161-1169. Published online November 30, 2004; 10.1124/jpet.104.075267 [Abstract] [Full Text] [PDF]  

Buyean Lee, Donna M. Platt, James K. Rowlett, Adepero S. Adewale, and Roger D. Spealman

Attenuation of Behavioral Effects of Cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in Squirrel Monkeys: Comparison with Dizocilpine
J Pharmacol Exp Ther 2005 312: 1232-1240. Published online November 18, 2004; 10.1124/jpet.104.078733 [Abstract] [Full Text] [PDF]  

James K. Rowlett, Joshua S. Rodefer, and Roger D. Spealman

Self-Administration of Cocaine-Opioid Combinations by Rhesus Monkeys: Evaluation of the Role of µ Receptor Efficacy Using Labor Supply Analysis
J Pharmacol Exp Ther 2005 312: 1289-1297. Published online November 18, 2004; 10.1124/jpet.104.076646 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Chun-Yang Xiao, Min Chen, Zsuzsanna Zsengellér, Hongshan Li, Levente Kiss, Márk Kollai, and Csaba Szabó

Poly(ADP-Ribose) Polymerase Promotes Cardiac Remodeling, Contractile Failure, and Translocation of Apoptosis-Inducing Factor in a Murine Experimental Model of Aortic Banding and Heart Failure
J Pharmacol Exp Ther 2005 312: 891-898. Published online November 2, 2004; 10.1124/jpet.104.077164 [Abstract] [Full Text] [PDF]  

Agostino Virdis, Rocchina Colucci, Matteo Fornai, Corrado Blandizzi, Emiliano Duranti, Stefania Pinto, Nunzia Bernardini, Cristina Segnani, Luca Antonioli, Stefano Taddei, Antonio Salvetti, and Mario Del Tacca

Cyclooxygenase-2 Inhibition Improves Vascular Endothelial Dysfunction in a Rat Model of Endotoxic Shock: Role of Inducible Nitric-Oxide Synthase and Oxidative Stress
J Pharmacol Exp Ther 2005 312: 945-953. Published online November 16, 2004; 10.1124/jpet.104.077644 [Abstract] [Full Text] [PDF]  

Kumkum Ganguly, Tatiana Krasik, Sandra Medinilla, Khalil Bdeir, Douglas B. Cines, Vladimir R. Muzykantov, and Juan Carlos Murciano

Blood Clearance and Activity of Erythrocyte-Coupled Fibrinolytics
J Pharmacol Exp Ther 2005 312: 1106-1113. Published online November 3, 2004; 10.1124/jpet.104.075770 [Abstract] [Full Text] [PDF]  

Olga Vitseva, David A. Flockhart, Yan Jin, Sonia Varghese, and Jane E. Freedman

The Effects of Tamoxifen and Its Metabolites on Platelet Function and Release of Reactive Oxygen Intermediates
J Pharmacol Exp Ther 2005 312: 1144-1150. Published online October 27, 2004; 10.1124/jpet.104.076315 [Abstract] [Full Text] [PDF]  

Sally Purdom and Qin M. Chen

Epidermal Growth Factor Receptor-Dependent and -Independent Pathways in Hydrogen Peroxide-Induced Mitogen-Activated Protein Kinase Activation in Cardiomyocytes and Heart Fibroblasts
J Pharmacol Exp Ther 2005 312: 1179-1186. Published online December 1, 2004; 10.1124/jpet.104.077057 [Abstract] [Full Text] [PDF]  

Yau-Chi Chan, Fung-Ping Leung, Xiaoqiang Yao, Chi-Wai Lau, Paul M. Vanhoutte, and Yu Huang

Raloxifene Relaxes Rat Pulmonary Arteries and Veins: Roles of Gender, Endothelium, and Antagonism of Ca²⁺ Influx
J Pharmacol Exp Ther 2005 312: 1266-1271. Published online November 18, 2004; 10.1124/jpet.104.077990 [Abstract] [Full Text] [PDF]  

Raquel Binda Pereira, Carmem Luíza Sartório, Dalton Valentim Vassallo, and Ivanita Stefanon

Differences in Tail Vascular Bed Reactivity in Rats with and without Heart Failure following Myocardial Infarction
J Pharmacol Exp Ther 2005 312: 1321-1325. Published online November 23, 2004; 10.1124/jpet.104.077701 [Abstract] [Full Text] [PDF]  

Hai Wang, Chao-Liang Long, and Ying-Li Zhang

A New ATP-Sensitive Potassium Channel Opener Reduces Blood Pressure and Reverses Cardiovascular Remodeling in Experimental Hypertension
J Pharmacol Exp Ther 2005 312: 1326-1333. Published online November 3, 2004; 10.1124/jpet.104.078220 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Stephen Hsu, Tetsuya Yamamoto, James Borke, Douglas S. Walsh, Baldev Singh, Sushma Rao, Kamatani Takaaki, Nam Nah-Do, Carol Lapp, David Lapp, Emily Foster, Wendy B. Bollag, Jill Lewis, John Wataha, Tokio Osaki, and George Schuster

Green Tea Polyphenol-Induced Epidermal Keratinocyte Differentiation Is Associated with Coordinated Expression of p57/KIP2 and Caspase 14
J Pharmacol Exp Ther 2005 312: 884-890. Published online November 10, 2004; 10.1124/jpet.104.076075 [Abstract] [Full Text] [PDF]  

JangJa Hong, Aya Yokomakura, Yasuhiro Nakano, Hyun Seung Ban, Kenji Ishihara, Jong-Woong Ahn, OkPyo Zee, and Kazuo Ohuchi

Induction of Nitric Oxide Production by the Cytostatic Macrolide Apicularen A [2,4-Heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 Dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)] and Possible Role of Nitric Oxide in Apicularen A-Induced Apoptosis in RAW 264.7 Cells
J Pharmacol Exp Ther 2005 312: 968-977. Published online November 23, 2004; 10.1124/jpet.104.077248 [Abstract] [Full Text] [PDF]  

Khosrow Kashfi, Simona Borgo, Jennie L. Williams, Jie Chen, Jianjun Gao, Athanasios Glekas, Francesca Benedini, Piero del Soldato, and Basil Rigas

Positional Isomerism Markedly Affects the Growth Inhibition of Colon Cancer Cells by Nitric Oxide-Donating Aspirin in Vitro and in Vivo
J Pharmacol Exp Ther 2005 312: 978-988. Published online November 4, 2004; 10.1124/jpet.104.075994 [Abstract] [Full Text] [PDF]  

Jianjun Gao, Khosrow Kashfi, and Basil Rigas

In Vitro Metabolism of Nitric Oxide-Donating Aspirin: The Effect of Positional Isomerism
J Pharmacol Exp Ther 2005 312: 989-997. Published online November 4, 2004; 10.1124/jpet.104.076190 [Abstract] [Full Text] [PDF]  

Fang Li and Kafait U. Malik

Angiotensin II-Induced Akt Activation through the Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells Is Mediated by Phospholipid Metabolites Derived by Activation of Phospholipase D
J Pharmacol Exp Ther 2005 312: 1043-1054. Published online November 3, 2004; 10.1124/jpet.104.076588 [Abstract] [Full Text] [PDF] Data Supplement  

Dana S. Hutchinson, Masaaki Sato, Bronwyn A. Evans, Arthur Christopoulos, and Roger J. Summers

Evidence for Pleiotropic Signaling at the Mouse ₃-Adrenoceptor Revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol Oxalate]
J Pharmacol Exp Ther 2005 312: 1064-1074. Published online December 1, 2004; 10.1124/jpet.104.076901 [Abstract] [Full Text] [PDF]  

Wendy B. Bollag, Xiaofeng Zhong, M. Ernest Dodd, David M. Hardy, Xiangjian Zheng, and W. Thomas Allred

Phospholipase D Signaling and Extracellular Signal-Regulated Kinase-1 and -2 Phosphorylation (Activation) Are Required for Maximal Phorbol Ester-Induced Transglutaminase Activity, a Marker of Keratinocyte Differentiation
J Pharmacol Exp Ther 2005 312: 1223-1231. Published online November 10, 2004; 10.1124/jpet.104.075622 [Abstract] [Full Text] [PDF]  

Virginie Bourlier, Alexia Zakaroff-Girard, Sandra De Barros, Christophe Pizzacalla, Véronique Durand de Saint Front, Max Lafontan, Anne Bouloumié, and Jean Galitzky

Protease Inhibitor Treatments Reveal Specific Involvement of Matrix Metalloproteinase-9 in Human Adipocyte Differentiation
J Pharmacol Exp Ther 2005 312: 1272-1279. Published online November 10, 2004; 10.1124/jpet.104.077263 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Shih-Wei Wang, Shiow-Lin Pan, Jih-Hwa Guh, Hui-Ling Chen, Dong-Ming Huang, Ya-Ling Chang, Sheng-Chu Kuo, Fang-Yu Lee, and Che-Ming Teng

YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G₀-G₁ in Human Hepatocellular Carcinoma Cells
J Pharmacol Exp Ther 2005 312: 917-925. Published online November 3, 2004; 10.1124/jpet.104.077230 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Cemil Göçmen, Ben Giesselman, and William C. de Groat

Effect of Neocuproine, a Copper(I) Chelator, on Rat Bladder Function
J Pharmacol Exp Ther 2005 312: 1138-1143. Published online October 22, 2004; 10.1124/jpet.104.076398 [Abstract] [Full Text] [PDF]  

Nimesh S. A. Patel, Prabal K. Chatterjee, Rosanna Di Paola, Emanuela Mazzon, Domenico Britti, Angelina De Sarro, Salvatore Cuzzocrea, and Christoph Thiemermann

Endogenous Interleukin-6 Enhances the Renal Injury, Dysfunction, and Inflammation Caused by Ischemia/Reperfusion
J Pharmacol Exp Ther 2005 312: 1170-1178. Published online November 30, 2004; 10.1124/jpet.104.078659 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Toshihiko Yamauchi, Akira Ishibashi, Kohdoh Shikata, Naoki Tokuhara, Ken-ichiro Seino, Seiichi Kobayashi, and Mitsuo Nagai

Effect of E6060 [4-{5-[7-Fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic Acid], a Novel Subtype-Selective Retinoid, on Lupus-Like Nephritis in Female (NZBxNZW)F1 Mice
J Pharmacol Exp Ther 2005 312: 938-944. Published online December 22, 2004; 10.1124/jpet.104.075598 [Abstract] [Full Text] [PDF]  

Yoshiki Shiraishi, Koichiro Asano, Takeshi Nakajima, Tsuyoshi Oguma, Yusuke Suzuki, Tetsuya Shiomi, Koichi Sayama, Kyoko Niimi, Misa Wakaki, Junko Kagyo, Eiji Ikeda, Hiroyuki Hirai, Kazuhiro Yamaguchi, and Akitoshi Ishizaka

Prostaglandin D₂-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor
J Pharmacol Exp Ther 2005 312: 954-960. Published online November 4, 2004; 10.1124/jpet.104.078212 [Abstract] [Full Text] [PDF]  

Yusheng Han, Joshua A. Englert, Runkuan Yang, Russell L. Delude, and Mitchell P. Fink

Ethyl Pyruvate Inhibits Nuclear Factor-B-Dependent Signaling by Directly Targeting p65
J Pharmacol Exp Ther 2005 312: 1097-1105. Published online November 3, 2004; 10.1124/jpet.104.079707 [Abstract] [Full Text] [PDF]  

Jong Soon Kang, Yeo Dae Yoon, Ig Jun Cho, Mi Hwa Han, Chang Woo Lee, Song-Kyu Park, and Hwan Mook Kim

Glabridin, an Isoflavan from Licorice Root, Inhibits Inducible Nitric-Oxide Synthase Expression and Improves Survival of Mice in Experimental Model of Septic Shock
J Pharmacol Exp Ther 2005 312: 1187-1194. Published online November 10, 2004; 10.1124/jpet.104.077107 [Abstract] [Full Text] [PDF]  

James K. Gierse, Yan Zhang, William F. Hood, Mark C. Walker, Jennifer S. Trigg, Timothy J. Maziasz, Carol M. Koboldt, Jerry L. Muhammad, Ben S. Zweifel, Jaime L. Masferrer, Peter C. Isakson, and Karen Seibert

Valdecoxib: Assessment of Cyclooxygenase-2 Potency and Selectivity
J Pharmacol Exp Ther 2005 312: 1206-1212. Published online October 19, 2004; 10.1124/jpet.104.076877 [Abstract] [Full Text] [PDF]  

So Youn Park, Jeong Hyun Lee, Yong Ki Kim, Chi Dae Kim, Byung Yong Rhim, Won Suk Lee, and Ki Whan Hong

Cilostazol Prevents Remnant Lipoprotein Particle-Induced Monocyte Adhesion to Endothelial Cells by Suppression of Adhesion Molecules and Monocyte Chemoattractant Protein-1 Expression via Lectin-Like Receptor for Oxidized Low-Density Lipoprotein Receptor Activation
J Pharmacol Exp Ther 2005 312: 1241-1248. Published online November 3, 2004; 10.1124/jpet.104.077826 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Bo Hu and Fang Zheng

Differential Effects on Current Kinetics by Point Mutations in the lurcher Motif of NR1/NR2A Receptors
J Pharmacol Exp Ther 2005 312: 899-904. Published online October 22, 2004; 10.1124/jpet.104.077388 [Abstract] [Full Text] [PDF]  

Oliver Stiedl, Michael Meyer, Olaf Jahn, Sven Ove Ögren, and Joachim Spiess

Corticotropin-Releasing Factor Receptor 1 and Central Heart Rate Regulation in Mice during Expression of Conditioned Fear
J Pharmacol Exp Ther 2005 312: 905-916. Published online November 10, 2004; 10.1124/jpet.104.075820 [Abstract] [Full Text] [PDF]  

Hasan Palandoken, Kolbot By, Manu Hegde, William R. Harley, Fredric A. Gorin, and Michael H. Nantz

Amiloride Peptide Conjugates: Prodrugs for Sodium-Proton Exchange Inhibition
J Pharmacol Exp Ther 2005 312: 961-967. Published online October 27, 2004; 10.1124/jpet.104.076984 [Abstract] [Full Text] [PDF] Data Supplement  

Leo H. Wang, Andrew J. Paden, and Eugene M. Johnson, Jr.

Mixed-Lineage Kinase Inhibitors Require the Activation of Trk Receptors to Maintain Long-Term Neuronal Trophism and Survival
J Pharmacol Exp Ther 2005 312: 1007-1019. Published online November 3, 2004; 10.1124/jpet.104.077800 [Abstract] [Full Text] [PDF]  

Laurent Bardin, Marie-Bernadette Assié, Martine Pélissou, Isabelle Royer-Urios, Adrian Newman-Tancredi, Jean-Paul Ribet, François Sautel, Wouter Koek, and Francis C. Colpaert

Dual, Hyperalgesic, and Analgesic Effects of the High-Efficacy 5-Hydroxytryptamine 1A (5-HT_1A) Agonist F 13640 [(3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, Fumaric Acid Salt]: Relationship with 5-HT_1A Receptor Occupancy and Kinetic Parameters
J Pharmacol Exp Ther 2005 312: 1034-1042. Published online November 4, 2004; 10.1124/jpet.104.077669 [Abstract] [Full Text] [PDF]  

Hiroyuki Watanabe, Daisuke Nakayama, Kanenori Ito, Chizuko Watanabe, Hirokazu Mizoguchi, Tsutomu Fujimura, Kimie Murayama, Shunsuke Kawamura, Takumi Sato, Chikai Sakurada, Tsukasa Sakurada, and Shinobu Sakurada

A Tyr-W-MIF-1 Analog Containing D-Pro² Acts as a Selective µ₂-Opioid Receptor Antagonist in the Mouse
J Pharmacol Exp Ther 2005 312: 1075-1081. Published online November 23, 2004; 10.1124/jpet.104.075697 [Abstract] [Full Text] [PDF]  

Peter H. Wu, Wolfgang Poelchen, and William R. Proctor

Differential GABA_B Receptor Modulation of Ethanol Effects on GABA_A Synaptic Activity in Hippocampal CA1 Neurons
J Pharmacol Exp Ther 2005 312: 1082-1089. Published online December 22, 2004; 10.1124/jpet.104.075663 [Abstract] [Full Text] [PDF]  

Giacomo Carrà, Anna Rizzi, Remo Guerrini, Timothy A. Barnes, John McDonald, Christopher P. Hebbes, Flora Mela, Velga A. Kenigs, Giuliano Marzola, Daniela Rizzi, Elaine Gavioli, Silvia Zucchini, Domenico Regoli, Michele Morari, Severo Salvadori, David J. Rowbotham, David G. Lambert, Daniel R. Kapusta, and Girolamo Calo'

[(pF)Phe⁴,Arg¹⁴,Lys¹⁵]N/OFQ-NH₂ (UFP-102), a Highly Potent and Selective Agonist of the Nociceptin/Orphanin FQ Receptor
J Pharmacol Exp Ther 2005 312: 1114-1123. Published online October 27, 2004; 10.1124/jpet.104.077339 [Abstract] [Full Text] [PDF]  

Mayuko Oda, Norihito Kitagawa, Bang-Xiang Yang, Tadahide Totoki, and Masatoshi Morimoto

Quantitative and Fiber-Selective Evaluation of Dose-Dependent Nerve Blockade by Intrathecal Lidocaine in Rats
J Pharmacol Exp Ther 2005 312: 1132-1137. Published online November 30, 2004; 10.1124/jpet.104.076893 [Abstract] [Full Text] [PDF]  

Yasco Aracava, Edna F. R. Pereira, Alfred Maelicke, and Edson X. Albuquerque

Memantine Blocks 7^* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons
J Pharmacol Exp Ther 2005 312: 1195-1205. Published online November 2, 2004; 10.1124/jpet.104.077172 [Abstract] [Full Text] [PDF]  

M. Hajós, R. S. Hurst, W. E. Hoffmann, M. Krause, T. M. Wall, N. R. Higdon, and V. E. Groppi

The Selective 7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats
J Pharmacol Exp Ther 2005 312: 1213-1222. Published online November 2, 2004; 10.1124/jpet.104.076968 [Abstract] [Full Text] [PDF]  

Maia Terashvili, Hsiang-en Wu, Randy J. Leitermann, Han-Sen Sun, Andrew D. Clithero, and Leon F. Tseng

Differential Mechanisms of Antianalgesia Induced by Endomorphin-1 and Endomorphin-2 in the Ventral Periaqueductal Gray of the Rat
J Pharmacol Exp Ther 2005 312: 1257-1265. Published online November 12, 2004; 10.1124/jpet.104.076224 [Abstract] [Full Text] [PDF]  

Mahboubeh Tavakoli-Nezhad and David K. Pitts

Postnatal Inorganic Lead Exposure Reduces Midbrain Dopaminergic Impulse Flow and Decreases Dopamine D1 Receptor Sensitivity in Nucleus Accumbens Neurons
J Pharmacol Exp Ther 2005 312: 1280-1288. Published online November 18, 2004; 10.1124/jpet.104.076166 [Abstract] [Full Text] [PDF]  

Ying-Jun Cao, Carol S. Surowy, and Pamela S. Puttfarcken

Nicotinic Acetylcholine Receptor-Mediated [³H]Dopamine Release from Hippocampus
J Pharmacol Exp Ther 2005 312: 1298-1304. Published online November 12, 2004; 10.1124/jpet.104.076794 [Abstract] [Full Text] [PDF]  

Fernando J. Nasif, Kyriaki Sidiropoulou, Xiu-Ti Hu, and Francis J. White

Repeated Cocaine Administration Increases Membrane Excitability of Pyramidal Neurons in the Rat Medial Prefrontal Cortex
J Pharmacol Exp Ther 2005 312: 1305-1313. Published online December 1, 2004; 10.1124/jpet.104.075184 [Abstract] [Full Text] [PDF]  

Emily M. Jutkiewicz, Nicholas P. Walker, John E. Folk, Kenner C. Rice, Philip S. Portoghese, James H. Woods, and John R. Traynor

Comparison of Peptidic and Nonpeptidic -Opioid Agonists on Guanosine 5'-O-(3-[³⁵S]thio)triphosphate ([³⁵S]GTPS) Binding in Brain Slices from Sprague-Dawley Rats
J Pharmacol Exp Ther 2005 312: 1314-1320. Published online December 1, 2004; 10.1124/jpet.104.078741 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Jose M. Jimenez-Lopez and Arthur I. Cederbaum

Protein Kinase C Signaling as a Survival Pathway against CYP2E1-Derived Oxidative Stress and Toxicity in HepG2 Cells
J Pharmacol Exp Ther 2005 312: 998-1006. Published online October 19, 2004; 10.1124/jpet.104.076737 [Abstract] [Full Text] [PDF]  

Michael D. Aleo, Colleen M. Doshna, and Kimberly A. Navetta

Ciglitazone-Induced Lenticular Opacities in Rats: In Vivo and Whole Lens Explant Culture Evaluation
J Pharmacol Exp Ther 2005 312: 1027-1033. Published online November 2, 2004; 10.1124/jpet.104.076950 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systematically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat"
J Pharmacol Exp Ther 2005 312: 1334. [Full Text] [PDF]  

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