PERSPECTIVES IN PHARMACOLOGY:

Robert B. Raffa, Joseph R. Iannuzzo, Diana R. Levine, Kamal K. Saeid, Rachel C. Schwartz, Nicholas T. Sucic, Oksana D. Terleckyj, and Jeffrey M. Young

Bacterial Communication ("Quorum Sensing") via Ligands and Receptors: A Novel Pharmacologic Target for the Design of Antibiotic Drugs
J Pharmacol Exp Ther 2005 312: 417-423. Published online November 4, 2004; 10.1124/jpet.104.075150 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Mark D. Erion, Paul D. van Poelje, Deidre A. MacKenna, Timothy J. Colby, Annika C. Montag, James M. Fujitaki, David L. Linemeyer, and David A. Bullough

Liver-Targeted Drug Delivery Using HepDirect Prodrugs
J Pharmacol Exp Ther 2005 312: 554-560. Published online August 31, 2004; 10.1124/jpet.104.075903 [Abstract] [Full Text] [PDF]  

Xiulong Song, Yuxin Li, Jirong Liu, Madhu Mukundan, and Bingfang Yan

Simultaneous Substitution of Phenylalanine-305 and Aspartate-318 of Rat Pregnane X Receptor with the Corresponding Human Residues Abolishes the Ability to Transactivate the CYP3A23 Promoter
J Pharmacol Exp Ther 2005 312: 571-582. Published online September 14, 2004; 10.1124/jpet.104.074971 [Abstract] [Full Text] [PDF]  

C. Steven Ernest, II, Stephen D. Hall, and David R. Jones

Mechanism-Based Inactivation of CYP3A by HIV Protease Inhibitors
J Pharmacol Exp Ther 2005 312: 583-591. Published online November 2, 2004; 10.1124/jpet.104.075416 [Abstract] [Full Text] [PDF]  

Ryo Kato, Tomoji Maeda, Toshihiro Akaike, and Ikumi Tamai

Nucleoside Transport at the Blood-Testis Barrier Studied with Primary-Cultured Sertoli Cells
J Pharmacol Exp Ther 2005 312: 601-608. Published online November 16, 2004; 10.1124/jpet.104.073387 [Abstract] [Full Text] [PDF]  

Keitaro Sou, Robert Klipper, Beth Goins, Eishun Tsuchida, and William T. Phillips

Circulation Kinetics and Organ Distribution of Hb-Vesicles Developed as a Red Blood Cell Substitute
J Pharmacol Exp Ther 2005 312: 702-709. Published online September 30, 2004; 10.1124/jpet.104.074534 [Abstract] [Full Text] [PDF]  

Xunshan Ding and Jeff L. Staudinger

Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway
J Pharmacol Exp Ther 2005 312: 849-856. Published online September 30, 2004; 10.1124/jpet.104.076331 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Susanna Fürst, Pal Riba, Tamas Friedmann, Julia Tímar, Mahmoud Al-Khrasani, Ilona Obara, Wioletta Makuch, Mariana Spetea, Johannes Schütz, Ryszard Przewlocki, Barbara Przewlocka, and Helmut Schmidhammer

Peripheral versus Central Antinociceptive Actions of 6-Amino Acid-Substituted Derivatives of 14-O-Methyloxymorphone in Acute and Inflammatory Pain in the Rat
J Pharmacol Exp Ther 2005 312: 609-618. Published online September 21, 2004; 10.1124/jpet.104.075176 [Abstract] [Full Text] [PDF]  

Rebecca J. Ralph and S. Barak Caine

Dopamine D1 and D2 Agonist Effects on Prepulse Inhibition and Locomotion: Comparison of Sprague-Dawley Rats to Swiss-Webster, 129X1/SvJ, C57BL/6J, and DBA/2J Mice
J Pharmacol Exp Ther 2005 312: 733-741. Published online October 19, 2004; 10.1124/jpet.104.074468 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Albert S. Jung, Michael P. Quaile, Geoffrey D. Mills, Daniel P. Bednarik, Steven R. Houser, and Kenneth B. Margulies

Pharmacological Effects of ATI22-107 [2-(2-{2-[2-Chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic Acid Dimethyl Ester)], a Novel Dual Pharmacophore, on Myocyte Calcium Cycling and Contractility
J Pharmacol Exp Ther 2005 312: 517-524. Published online November 18, 2004; 10.1124/jpet.104.075895 [Abstract] [Full Text] [PDF]  

Chun-Mei Cao, Qiang Xia, Qin Gao, Mai Chen, and Tak-Ming Wong

Calcium-Activated Potassium Channel Triggers Cardioprotection of Ischemic Preconditioning
J Pharmacol Exp Ther 2005 312: 644-650. Published online September 2, 2004; 10.1124/jpet.104.074476 [Abstract] [Full Text] [PDF]  

Roberta Foresti, Martha Hoque, Diego Monti, Colin J. Green, and Roberto Motterlini

Differential Activation of Heme Oxygenase-1 by Chalcones and Rosolic Acid in Endothelial Cells
J Pharmacol Exp Ther 2005 312: 686-693. Published online November 10, 2004; 10.1124/jpet.104.074153 [Abstract] [Full Text] [PDF]  

D. Adam Lauver, Erin A. Booth, Andrew J. White, Enrique Poradosu, and Benedict R. Lucchesi

Sulodexide Attenuates Myocardial Ischemia/Reperfusion Injury and the Deposition of C-Reactive Protein in Areas of Infarction without Affecting Hemostasis
J Pharmacol Exp Ther 2005 312: 794-800. Published online September 13, 2004; 10.1124/jpet.104.075283 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Y. Jeffrey Wu, Leslie L. Muldoon, and Edward A. Neuwelt

The Chemoprotective Agent N-Acetylcysteine Blocks Cisplatin-Induced Apoptosis through Caspase Signaling Pathway
J Pharmacol Exp Ther 2005 312: 424-431. Published online October 20, 2004; 10.1124/jpet.104.075119 [Abstract] [Full Text] [PDF] Erratum  

A. Banan, L. J. Zhang, A. Farhadi, J. Z. Fields, M. Shaikh, C. B. Forsyth, S. Choudhary, and A. Keshavarzian

Critical Role of the Atypical Isoform of Protein Kinase C (PKC-) in Oxidant-Induced Disruption of the Microtubule Cytoskeleton and Barrier Function of Intestinal Epithelium
J Pharmacol Exp Ther 2005 312: 458-471. Published online September 3, 2004; 10.1124/jpet.104.074591 [Abstract] [Full Text] [PDF]  

Georg T. Wondrak, Myron K. Jacobson, and Elaine L. Jacobson

Identification of Quenchers of Photoexcited States as Novel Agents for Skin Photoprotection
J Pharmacol Exp Ther 2005 312: 482-491. Published online October 8, 2004; 10.1124/jpet.104.075101 [Abstract] [Full Text] [PDF]  

Paul J. Kammermeier and June Yun

Activation of Metabotropic Glutamate Receptor 1 Dimers Requires Glutamate Binding in Both Subunits
J Pharmacol Exp Ther 2005 312: 502-508. Published online October 1, 2004; 10.1124/jpet.104.073155 [Abstract] [Full Text] [PDF]  

Giovanni Appendino, Luciano De Petrocellis, Marcello Trevisani, Alberto Minassi, Nives Daddario, Aniello Schiano Moriello, David Gazzieri, Alessia Ligresti, Barbara Campi, Gabriele Fontana, Christian Pinna, Pierangelo Geppetti, and Vincenzo Di Marzo

Development of the First Ultra-Potent "Capsaicinoid" Agonist at Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channels and Its Therapeutic Potential
J Pharmacol Exp Ther 2005 312: 561-570. Published online September 8, 2004; 10.1124/jpet.104.074864 [Abstract] [Full Text] [PDF]  

Aarti N. Desai, Kelly M. Standifer, and Douglas C. Eikenburg

Cellular G Protein-Coupled Receptor Kinase Levels Regulate Sensitivity of the _2B-Adrenergic Receptor to Undergo Agonist-Induced Down-Regulation
J Pharmacol Exp Ther 2005 312: 767-773. Published online September 29, 2004; 10.1124/jpet.104.076042 [Abstract] [Full Text] [PDF]  

Mary J. Clark and John R. Traynor

Endogenous Regulator of G Protein Signaling Proteins Reduce µ-Opioid Receptor Desensitization and Down-Regulation and Adenylyl Cyclase Tolerance in C6 Cells
J Pharmacol Exp Ther 2005 312: 809-815. Published online September 21, 2004; 10.1124/jpet.104.074641 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Shellie M. Callahan, Xin Ming, Shirley K. Lu, Lane J. Brunner, and Maria A. Croyle

Considerations for Use of Recombinant Adenoviral Vectors: Dose Effect on Hepatic Cytochromes P450
J Pharmacol Exp Ther 2005 312: 492-501. Published online October 20, 2004; 10.1124/jpet.104.075374 [Abstract] [Full Text] [PDF]  

Regine Schneider-Stock, Mona Diab-Assef, Astrid Rohrbeck, Charlotte Foltzer-Jourdainne, Carsten Boltze, Roland Hartig, Peter Schönfeld, Albert Roessner, and Hala Gali-Muhtasib

5-aza-Cytidine Is a Potent Inhibitor of DNA Methyltransferase 3a and Induces Apoptosis in HCT-116 Colon Cancer Cells via Gadd45- and p53-Dependent Mechanisms
J Pharmacol Exp Ther 2005 312: 525-536. Published online November 16, 2004; 10.1124/jpet.104.074195 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Jiyun Chen, Dong Jin Hwang, Casey E. Bohl, Duane D. Miller, and James T. Dalton

A Selective Androgen Receptor Modulator for Hormonal Male Contraception
J Pharmacol Exp Ther 2005 312: 546-553. Published online September 3, 2004; 10.1124/jpet.104.075424 [Abstract] [Full Text] [PDF]  

Simone Tambaro, Stefania Ruiu, Christian Dessi, Raymond Mongeau, Giorgio Marchese, and Luca Pani

Evaluation of Tamsulosin and Alfuzosin Activity in the Rat Vas Deferens: Relevance to Ejaculation Delays
J Pharmacol Exp Ther 2005 312: 710-717. Published online October 6, 2004; 10.1124/jpet.104.074740 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Frederick J. Ehlert, Jake Ching-Hsuan Hsu, Kevin Leung, Alex G. Lee, Darakhshanda Shehnaz, and Michael T. Griffin

Comparison of the Antimuscarinic Action of p-Fluorohexahydrosiladifenidol in Ileal and Tracheal Smooth Muscle
J Pharmacol Exp Ther 2005 312: 592-600. Published online September 29, 2004; 10.1124/jpet.104.074898 [Abstract] [Full Text] [PDF]  

Atsushi Masamune, Kazuhiro Kikuta, Masahiro Satoh, Noriaki Suzuki, and Tooru Shimosegawa

Protease-Activated Receptor-2-Mediated Proliferation and Collagen Production of Rat Pancreatic Stellate Cells
J Pharmacol Exp Ther 2005 312: 651-658. Published online September 14, 2004; 10.1124/jpet.104.076232 [Abstract] [Full Text] [PDF]  

Helmut B. Gottlieb, Kurt J. Varner, Velga A. Kenigs, Antonio M. Cabral, and Daniel R. Kapusta

Differential Cardiovascular and Renal Responses Produced by Microinjection of the -Opioid U-50488H [(trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzene-acetamide) Methane Sulfonate] into Subregions of the Paraventricular Nucleus
J Pharmacol Exp Ther 2005 312: 678-685. Published online September 20, 2004; 10.1124/jpet.104.076828 [Abstract] [Full Text] [PDF]  

Lihong Chen, Baichun Yang, Judi A. McNulty, Lisa G. Clifton, Jane G. Binz, Angela M. Grimes, Jay C. Strum, W. Wallace Harrington, Zibin Chen, Thomas W. Balon, Stephen A. Stimpson, and Kathleen K. Brown

GI262570, a Peroxisome Proliferator-Activated Receptor Agonist, Changes Electrolytes and Water Reabsorption from the Distal Nephron in Rats
J Pharmacol Exp Ther 2005 312: 718-725. Published online October 8, 2004; 10.1124/jpet.104.074088 [Abstract] [Full Text] [PDF]  

Rocio I. R. Macias, Maria A. Serrano, Maria J. Monte, Silvia Jimenez, Belen Hernandez, and Jose J. G. Marin

Long-Term Effect of Treating Pregnant Rats with Ursodeoxycholic Acid on the Congenital Impairment of Bile Secretion Induced in the Pups by Maternal Cholestasis
J Pharmacol Exp Ther 2005 312: 751-758. Published online September 27, 2004; 10.1124/jpet.104.075051 [Abstract] [Full Text] [PDF]  

Masaaki Miyata, Aki Tozawa, Hijiri Otsuka, Toshifumi Nakamura, Kiyoshi Nagata, Frank J. Gonzalez, and Yasushi Yamazoe

Role of Farnesoid X Receptor in the Enhancement of Canalicular Bile Acid Output and Excretion of Unconjugated Bile Acids: A Mechanism for Protection against Cholic Acid-Induced Liver Toxicity
J Pharmacol Exp Ther 2005 312: 759-766. Published online October 1, 2004; 10.1124/jpet.104.076158 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Akira Murai, Masayoshi Abe, Yuri Hayashi, Noriyuki Sakata, Takeshi Katsuragi, and Keiichi Tanaka

Comparison Study between the Mechanisms of Allergic Asthma Amelioration by a Cysteinyl-Leukotriene Type 1 Receptor Antagonist Montelukast and Methylprednisolone
J Pharmacol Exp Ther 2005 312: 432-440. Published online October 6, 2004; 10.1124/jpet.104.074922 [Abstract] [Full Text] [PDF]  

Carlton W. Thomas, Gennett M. Myhre, Renee Tschumper, Raghavakaimal Sreekumar, Diane Jelinek, David J. McKean, James J. Lipsky, William J. Sandborn, and Laurence J. Egan

Selective Inhibition of Inflammatory Gene Expression in Activated T Lymphocytes: A Mechanism of Immune Suppression by Thiopurines
J Pharmacol Exp Ther 2005 312: 537-545. Published online September 23, 2004; 10.1124/jpet.104.074815 [Abstract] [Full Text] [PDF]  

Guillaume Monneret, Radhia Boumiza, Sylvie Gravel, Chantal Cossette, Jacques Bienvenu, Joshua Rokach, and William S. Powell

Effects of Prostaglandin D₂ and 5-Lipoxygenase Products on the Expression of CD203c and CD11b by Basophils
J Pharmacol Exp Ther 2005 312: 627-634. Published online September 23, 2004; 10.1124/jpet.104.074823 [Abstract] [Full Text] [PDF]  

R. B. Pepinsky, W.-C. Lee, M. Cornebise, A. Gill, K. Wortham, L. L. Chen, D. R. Leone, K. Giza, B. M. Dolinski, S. Perper, C. Nickerson-Nutter, D. Lepage, A. Chakraborty, E. T. Whalley, R. C. Petter, S. P. Adams, R. R. Lobb, and D. M. Scott

Design, Synthesis, and Analysis of a Polyethelene Glycol-Modified (PEGylated) Small Molecule Inhibitor of Integrin 41 with Improved Pharmaceutical Properties
J Pharmacol Exp Ther 2005 312: 742-750. Published online October 14, 2004; 10.1124/jpet.104.075648 [Abstract] [Full Text] [PDF]  

Galen M. Pieper, Vani Nilakantan, Xianghua Zhou, Ashwani K. Khanna, Christopher P. Johnson, Allan M. Roza, Mark B. Adams, Gail Hilton, and Christopher C. Felix

Treatment with -Phenyl-N-tert-butylnitrone, a Free Radical-Trapping Agent, Abrogates Inflammatory Cytokine Gene Expression during Alloimmune Activation in Rat Cardiac Allografts
J Pharmacol Exp Ther 2005 312: 774-779. Published online September 3, 2004; 10.1124/jpet.104.076026 [Abstract] [Full Text] [PDF]  

Masahide Fukudo, Ikuko Yano, Satohiro Masuda, Masahiro Okuda, and Ken-ichi Inui

Distinct Inhibitory Effects of Tacrolimus and Cyclosporin A on Calcineurin Phosphatase Activity
J Pharmacol Exp Ther 2005 312: 816-825. Published online September 21, 2004; 10.1124/jpet.104.074930 [Abstract] [Full Text] [PDF]  

Shirley Teng and Micheline Piquette-Miller

The Involvement of the Pregnane X Receptor in Hepatic Gene Regulation during Inflammation in Mice
J Pharmacol Exp Ther 2005 312: 841-848. Published online September 29, 2004; 10.1124/jpet.104.076141 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Thomas F. Finnegan, Shao-Rui Chen, and Hui-Lin Pan

Effect of the µ Opioid on Excitatory and Inhibitory Synaptic Inputs to Periaqueductal Gray-Projecting Neurons in the Amygdala
J Pharmacol Exp Ther 2005 312: 441-448. Published online September 23, 2004; 10.1124/jpet.104.074633 [Abstract] [Full Text] [PDF]  

Tiziana Genovese, Emanuela Mazzon, Carmelo Muià, Nimesh S. A. Patel, Michael D. Threadgill, Placido Bramanti, Angelina De Sarro, Christoph Thiemermann, and Salvatore Cuzzocrea

Inhibitors of Poly(ADP-Ribose) Polymerase Modulate Signal Transduction Pathways and Secondary Damage in Experimental Spinal Cord Trauma
J Pharmacol Exp Ther 2005 312: 449-457. Published online September 27, 2004; 10.1124/jpet.104.076711 [Abstract] [Full Text] [PDF]  

Hidemitsu Nakajima, Nobukazu Kakui, Kunihiro Ohkuma, Midori Ishikawa, and Toshifumi Hasegawa

A Newly Synthesized Poly(ADP-Ribose) Polymerase Inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: Pharmacological Profiles, Neuroprotective Effects, and Therapeutic Time Window in Cerebral Ischemia in Rats
J Pharmacol Exp Ther 2005 312: 472-481. Published online October 1, 2004; 10.1124/jpet.104.075465 [Abstract] [Full Text] [PDF]  

Vladimir P. Grinevich, Sharon R. Letchworth, Kari A. Lindenberger, Jean Menager, Veronique Mary, Khalima A. Sadieva, Lori M. Buhlman, Georg Andrees Bohme, Laurent Pradier, Jesus Benavides, Ronald J. Lukas, and Merouane Bencherif

Heterologous Expression of Human 6435 Nicotinic Acetylcholine Receptors: Binding Properties Consistent with Their Natural Expression Require Quaternary Subunit Assembly Including the 5 Subunit
J Pharmacol Exp Ther 2005 312: 619-626. Published online September 8, 2004; 10.1124/jpet.104.075069 [Abstract] [Full Text] [PDF]  

D. M. Barten, V. L. Guss, J. A. Corsa, A. Loo, S. B. Hansel, M. Zheng, B. Munoz, K. Srinivasan, B. Wang, B. J. Robertson, C. T. Polson, J. Wang, S. B. Roberts, J. P. Hendrick, J. J. Anderson, J. K. Loy, R. Denton, T. A. Verdoorn, D. W. Smith, and K. M. Felsenstein

Dynamics of -Amyloid Reductions in Brain, Cerebrospinal Fluid, and Plasma of -Amyloid Precursor Protein Transgenic Mice Treated with a -Secretase Inhibitor
J Pharmacol Exp Ther 2005 312: 635-643. Published online September 27, 2004; 10.1124/jpet.104.075408 [Abstract] [Full Text] [PDF]  

M. L. Michaelis, S. Ansar, Y. Chen, E. R. Reiff, K. I. Seyb, R. H. Himes, K. L. Audus, and G. I. Georg

-Amyloid-Induced Neurodegeneration and Protection by Structurally Diverse Microtubule-Stabilizing Agents
J Pharmacol Exp Ther 2005 312: 659-668. Published online September 16, 2004; 10.1124/jpet.104.074450 [Abstract] [Full Text] [PDF]  

Victor L. Arvanian, Vladimir Motin, and Lorne M. Mendell

Comparison of Metabotropic Glutamate Receptor Responses at Segmental and Descending Inputs to Motoneurons in Neonatal Rat Spinal Cord
J Pharmacol Exp Ther 2005 312: 669-677. Published online September 21, 2004; 10.1124/jpet.104.075077 [Abstract] [Full Text] [PDF]  

Altaf S. Darvesh, Bryan K. Yamamoto, and Gary A. Gudelsky

Evidence for the Involvement of Nitric Oxide in 3,4-Methylenedioxymethamphetamine-Induced Serotonin Depletion in the Rat Brain
J Pharmacol Exp Ther 2005 312: 694-701. Published online September 29, 2004; 10.1124/jpet.104.074849 [Abstract] [Full Text] [PDF]  

Carrie K. Jones, Steven C. Peters, and Harlan E. Shannon

Efficacy of Duloxetine, a Potent and Balanced Serotonergic and Noradrenergic Reuptake Inhibitor, in Inflammatory and Acute Pain Models in Rodents
J Pharmacol Exp Ther 2005 312: 726-732. Published online October 19, 2004; 10.1124/jpet.104.075960 [Abstract] [Full Text] [PDF]  

M. I. Damaj, P. Flood, K. K. Ho, E. L. May, and B. R. Martin

Effect of Dextrometorphan and Dextrorphan on Nicotine and Neuronal Nicotinic Receptors: In Vitro and in Vivo Selectivity
J Pharmacol Exp Ther 2005 312: 780-785. Published online September 8, 2004; 10.1124/jpet.104.075093 [Abstract] [Full Text] [PDF]  

Leslie N. Johnson-Anuna, Gunter P. Eckert, Jan H. Keller, Urule Igbavboa, Cornelia Franke, Thomas Fechner, Manfred Schubert-Zsilavecz, Michael Karas, Walter E. Müller, and W. Gibson Wood

Chronic Administration of Statins Alters Multiple Gene Expression Patterns in Mouse Cerebral Cortex
J Pharmacol Exp Ther 2005 312: 786-793. Published online September 9, 2004; 10.1124/jpet.104.075028 [Abstract] [Full Text] [PDF]  

Wei Ouyang and Hugh C. Hemmings, Jr.

Depression by Isoflurane of the Action Potential and Underlying Voltage-Gated Ion Currents in Isolated Rat Neurohypophysial Nerve Terminals
J Pharmacol Exp Ther 2005 312: 801-808. Published online September 16, 2004; 10.1124/jpet.104.074609 [Abstract] [Full Text] [PDF]  

I. Feinberg, D. D. Schoepp, K.-C. Hsieh, N. Darchia, and I. G. Campbell

The Metabotropic Glutamate (mGLU)2/3 Receptor Antagonist LY341495 [2S-2-Amino-2-(1S,2S-2-carboxycyclopropyl-1-yl)-3-(xanth-9-yl)propanoic Acid] Stimulates Waking and Fast Electroencephalogram Power and Blocks the Effects of the mGLU2/3 Receptor Agonist LY379268 [(-)-2-Oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate] in Rats
J Pharmacol Exp Ther 2005 312: 826-833. Published online September 21, 2004; 10.1124/jpet.104.076547 [Abstract] [Full Text] [PDF]  

Naohito Shimoyama, Megumi Shimoyama, Antonia M. Davis, Daniel T. Monaghan, and Charles E. Inturrisi

An Antisense Oligonucleotide to the N-Methyl-D-aspartate (NMDA) Subunit NMDAR1 Attenuates NMDA-Induced Nociception, Hyperalgesia, and Morphine Tolerance
J Pharmacol Exp Ther 2005 312: 834-840. Published online September 23, 2004; 10.1124/jpet.104.074856 [Abstract] [Full Text] [PDF]  

H. Steve White, William P. Watson, Suzanne L. Hansen, Scott Slough, Jens Perregaard, Alan Sarup, Tina Bolvig, Gitte Petersen, Orla M. Larsson, Rasmus P. Clausen, Bente Frølund, Erik Falch, Povl Krogsgaard-Larsen, and Arne Schousboe

First Demonstration of a Functional Role for Central Nervous System Betaine/-Aminobutyric Acid Transporter (mGAT2) Based on Synergistic Anticonvulsant Action among Inhibitors of mGAT1 and mGAT2
J Pharmacol Exp Ther 2005 312: 866-874. Published online November 18, 2004; 10.1124/jpet.104.068825 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Angela B. Reid, Richard C. Kurten, Sandra S. McCullough, Robert W. Brock, and Jack A. Hinson

Mechanisms of Acetaminophen-Induced Hepatotoxicity: Role of Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse Hepatocytes
J Pharmacol Exp Ther 2005 312: 509-516. Published online October 1, 2004; 10.1124/jpet.104.075945 [Abstract] [Full Text] [PDF]  

R. Michael Baldwin, Michael A. Shultz, and Alan R. Buckpitt

Bioactivation of the Pulmonary Toxicants Naphthalene and 1-Nitronaphthalene by Rat CYP2F4
J Pharmacol Exp Ther 2005 312: 857-865. Published online October 27, 2004; 10.1124/jpet.104.075440 [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.