ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Young-Joo Lee, Hiroyuki Kusuhara, Johan W. Jonker, Alfred H. Schinkel, and Yuichi Sugiyama

Investigation of Efflux Transport of Dehydroepiandrosterone Sulfate and Mitoxantrone at the Mouse Blood-Brain Barrier: A Minor Role of Breast Cancer Resistance Protein
J Pharmacol Exp Ther 2005 312: 44-52. Published online September 24, 2004; 10.1124/jpet.104.073320 [Abstract] [Full Text] [PDF]  

Shirou Itagaki, Yoshitaka Saito, Sayaka Kubo, Yukio Otsuka, Yuta Yamamoto, Masaki Kobayashi, Takeshi Hirano, and Ken Iseki

H⁺-Dependent Transport Mechanism of Nateglinide in the Brush-Border Membrane of the Rat Intestine
J Pharmacol Exp Ther 2005 312: 77-82. Published online August 17, 2004; 10.1124/jpet.104.074021 [Abstract] [Full Text] [PDF]  

Petr Pavek, Gracia Merino, Els Wagenaar, Ellen Bolscher, Martina Novotna, Johan W. Jonker, and Alfred H. Schinkel

Human Breast Cancer Resistance Protein: Interactions with Steroid Drugs, Hormones, the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and Transport of Cimetidine
J Pharmacol Exp Ther 2005 312: 144-152. Published online September 13, 2004; 10.1124/jpet.104.073916 [Abstract] [Full Text] [PDF]  

Erik Rytting and Kenneth L. Audus

Novel Organic Cation Transporter 2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells
J Pharmacol Exp Ther 2005 312: 192-198. Published online August 17, 2004; 10.1124/jpet.104.072363 [Abstract] [Full Text] [PDF]  

Noha N. Salama, Alessio Fasano, Manjusha Thakar, and Natalie D. Eddington

The Impact of G on the Oral Bioavailability of Low Bioavailable Therapeutic Agents
J Pharmacol Exp Ther 2005 312: 199-205. Published online September 24, 2004; 10.1124/jpet.104.073205 [Abstract] [Full Text] [PDF]  

Hideo Hiraoka, Naoji Kimura, Yumiko Furukawa, Ken-ichi Ogawara, Toshikiro Kimura, and Kazutaka Higaki

Up-Regulation of P-Glycoprotein Expression in Small Intestine under Chronic Serotonin-Depleted Conditions in Rats
J Pharmacol Exp Ther 2005 312: 248-255. Published online October 1, 2004; 10.1124/jpet.104.071290 [Abstract] [Full Text] [PDF]  

Hiroyuki Nishikawa, Kenzo Kawai, Makoto Tanaka, Hiroya Ohtani, Shuichi Tanaka, Chizuko Kitagawa, Minoru Nishida, Tomoyuki Abe, Hiromasa Araki, and Atusufumi Kawabata

Protease-Activated Receptor-2 (PAR-2)-Related Peptides Induce Tear Secretion in Rats: Involvement of PAR-2 and Non-PAR-2 Mechanisms
J Pharmacol Exp Ther 2005 312: 324-331. Published online August 26, 2004; 10.1124/jpet.104.072074 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Paul W. Czoty, Ciara McCabe, and Michael A. Nader

Assessment of the Relative Reinforcing Strength of Cocaine in Socially Housed Monkeys Using a Choice Procedure
J Pharmacol Exp Ther 2005 312: 96-102. Published online August 30, 2004; 10.1124/jpet.104.073411 [Abstract] [Full Text] [PDF]  

David A. Slattery, Sandrine Desrayaud, and John F. Cryan

GABA_B Receptor Antagonist-Mediated Antidepressant-Like Behavior Is Serotonin-Dependent
J Pharmacol Exp Ther 2005 312: 290-296. Published online August 27, 2004; 10.1124/jpet.104.073536 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Anthony A. Fossa, Todd Wisialowski, Anthony Magnano, Eric Wolfgang, Roxanne Winslow, William Gorczyca, Kimberly Crimin, and David L. Raunig

Dynamic Beat-to-Beat Modeling of the QT-RR Interval Relationship: Analysis of QT Prolongation during Alterations of Autonomic State versus Human Ether a-go-go-Related Gene Inhibition
J Pharmacol Exp Ther 2005 312: 1-11. Published online August 11, 2004; 10.1124/jpet.104.073288 [Abstract] [Full Text] [PDF] [Video Data Supplements]   

Brenda Schoffstall, Aya Kataoka, Amanda Clark, and P. Bryant Chase

Effects of Rapamycin on Cardiac and Skeletal Muscle Contraction and Crossbridge Cycling
J Pharmacol Exp Ther 2005 312: 12-18. Published online August 11, 2004; 10.1124/jpet.104.073445 [Abstract] [Full Text] [PDF]  

Xiaohong Tracey Gan, Venkatesh Rajapurohitam, James V. Haist, Peter Chidiac, Michael A. Cook, and Morris Karmazyn

Inhibition of Phenylephrine-Induced Cardiomyocyte Hypertrophy by Activation of Multiple Adenosine Receptor Subtypes
J Pharmacol Exp Ther 2005 312: 27-34. Published online September 27, 2004; 10.1124/jpet.104.073122 [Abstract] [Full Text] [PDF]  

Sheila M. Gardiner, Julie E. March, Philip A. Kemp, Anthony P. Davenport, Katherine E. Wiley, and Terence Bennett

Regional Hemodynamic Actions of Selective Corticotropin-Releasing Factor Type 2 Receptor Ligands in Conscious Rats
J Pharmacol Exp Ther 2005 312: 53-60. Published online August 24, 2004; 10.1124/jpet.104.075259 [Abstract] [Full Text] [PDF]  

So-Young Lee and Chin O. Lee

Inhibition of Na⁺-K⁺ Pump and L-Type Ca²⁺ Channel by Glibenclamide in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 2005 312: 61-68. Published online September 13, 2004; 10.1124/jpet.104.074369 [Abstract] [Full Text] [PDF]  

Guohu Li, Yuhui Xiao, and Lubo Zhang

Cocaine Induces Apoptosis in Fetal Rat Myocardial Cells through the p38 Mitogen-Activated Protein Kinase and Mitochondrial/Cytochrome c Pathways
J Pharmacol Exp Ther 2005 312: 112-119. Published online September 13, 2004; 10.1124/jpet.104.073494 [Abstract] [Full Text] [PDF]  

Yong-Ri Jin, Mi-Ra Cho, Chung-Kyu Ryu, Jin-Ho Chung, Dong-Yeon Yuk, Jin-Tae Hong, Kyung-Sup Lee, Jung-Jin Lee, Mi-Yea Lee, Yong Lim, and Yeo-Pyo Yun

Antiplatelet Activity of J78 (2-Chloro-3-[2'-bromo, 4'-fluoro-phenyl]-amino-8-hydroxy-1,4-naphthoquinone), an Antithrombotic Agent, Is Mediated by Thromboxane (TX) A₂ Receptor Blockade with TXA₂ Synthase Inhibition and Suppression of Cytosolic Ca²+ Mobilization
J Pharmacol Exp Ther 2005 312: 214-219. Published online August 24, 2004; 10.1124/jpet.104.073718 [Abstract] [Full Text] [PDF]  

William E. Louch, Gregory R. Ferrier, and Susan E. Howlett

Attentuation of Cardiac Stunning by Losartan in a Cellular Model of Ischemia and Reperfusion Is Accompanied by Increased Sarcoplasmic Reticulum Ca²⁺ Stores and Prevention of Cytosolic Ca²⁺ Elevation
J Pharmacol Exp Ther 2005 312: 238-247. Published online August 17, 2004; 10.1124/jpet.104.072769 [Abstract] [Full Text] [PDF]  

S. M. Gardiner, J. E. March, P. A. Kemp, S. A. Ballard, E. Hawkeswood, B. Hughes, and T. Bennett

Hemodynamic Effects of Phosphodiesterase 5 and Angiotensin-Converting Enzyme Inhibition Alone or in Combination in Conscious SHR
J Pharmacol Exp Ther 2005 312: 265-271. Published online September 27, 2004; 10.1124/jpet.104.071993 [Abstract] [Full Text] [PDF]  

Nahid Seyedi, Christina J. Mackins, Takuji Machida, Alicia C. Reid, Randi B. Silver, and Roberto Levi

Histamine H₃-Receptor-Induced Attenuation of Norepinephrine Exocytosis: A Decreased Protein Kinase A Activity Mediates a Reduction in Intracellular Calcium
J Pharmacol Exp Ther 2005 312: 272-280. Published online August 11, 2004; 10.1124/jpet.104.072504 [Abstract] [Full Text] [PDF]  

Lazaros A. Nikolaidis, Aaron Doverspike, Teresa Hentosz, Lee Zourelias, You-Tang Shen, Dariush Elahi, and Richard P. Shannon

Glucagon-Like Peptide-1 Limits Myocardial Stunning following Brief Coronary Occlusion and Reperfusion in Conscious Canines
J Pharmacol Exp Ther 2005 312: 303-308. Published online September 8, 2004; 10.1124/jpet.104.073890 [Abstract] [Full Text] [PDF]  

Yuri A. Kuryshev, Eckhard Ficker, Lu Wang, Peter Hawryluk, Adrienne T. Dennis, Barbara A. Wible, Arthur M. Brown, Jiesheng Kang, Xiao-Liang Chen, Kaoru Sawamura, William Reynolds, and David Rampe

Pentamidine-Induced Long QT Syndrome and Block of hERG Trafficking
J Pharmacol Exp Ther 2005 312: 316-323. Published online August 31, 2004; 10.1124/jpet.104.073692 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Jingcai Chen, Chester Kuei, Steven W. Sutton, Pascal Bonaventure, Diane Nepomuceno, Elo Eriste, Rannar Sillard, Timothy W. Lovenberg, and Changlu Liu

Pharmacological Characterization of Relaxin-3/INSL7 Receptors GPCR135 and GPCR142 from Different Mammalian Species
J Pharmacol Exp Ther 2005 312: 83-95. Published online September 14, 2004; 10.1124/jpet.104.073486 [Abstract] [Full Text] [PDF]  

Nengyu Yang, Joanne S. Kays, Tiffanie R. Skillman, Lorri Burris, Thomas W. Seng, and Craig Hammond

C75 [4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic Acid] Activates Carnitine Palmitoyltransferase-1 in Isolated Mitochondria and Intact Cells without Displacement of Bound Malonyl CoA
J Pharmacol Exp Ther 2005 312: 127-133. Published online September 8, 2004; 10.1124/jpet.104.074104 [Abstract] [Full Text] [PDF]  

Rajesh S. Savkur, Jeffrey S. Thomas, Kelli S. Bramlett, Yunling Gao, Laura F. Michael, and Thomas P. Burris

Ligand-Dependent Coactivation of the Human Bile Acid Receptor FXR by the Peroxisome Proliferator-Activated Receptor Coactivator-1
J Pharmacol Exp Ther 2005 312: 170-178. Published online August 25, 2004; 10.1124/jpet.104.072124 [Abstract] [Full Text] [PDF]  

Mia Engström, Jussi Tomperi, Kamel El-Darwish, Mikaela Åhman, Juha-Matti Savola, and Siegfried Wurster

Superagonism at the Human Somatostatin Receptor Subtype 4
J Pharmacol Exp Ther 2005 312: 332-338. Published online August 27, 2004; 10.1124/jpet.104.075531 [Abstract] [Full Text] [PDF]  

Lauren T. May, Yvonne Lin, Patrick M. Sexton, and Arthur Christopoulos

Regulation of M₂ Muscarinic Acetylcholine Receptor Expression and Signaling by Prolonged Exposure to Allosteric Modulators
J Pharmacol Exp Ther 2005 312: 382-390. Published online August 27, 2004; 10.1124/jpet.104.073767 [Abstract] [Full Text] [PDF]  

Hyun Ju Song, Tai Sang Lee, Ji Hoon Jeong, Young Sil Min, Chang Yell Shin, and Uy Dong Sohn

Hydrogen Peroxide-Induced Extracellular Signal-Regulated Kinase Activation in Cultured Feline Ileal Smooth Muscle Cells
J Pharmacol Exp Ther 2005 312: 391-398. Published online August 24, 2004; 10.1124/jpet.104.074401 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Melissa L. Fishel, David R. Newell, Roger J. Griffin, Richard Davison, Lan-Zhen Wang, Nicola J. Curtin, Eleanor G. Zuhowski, Kristen Kasza, Merrill J. Egorin, Robert C. Moschel, and M. Eileen Dolan

Effect of Cell Cycle Inhibition on Cisplatin-Induced Cytotoxicity
J Pharmacol Exp Ther 2005 312: 206-213. Published online August 10, 2004; 10.1124/jpet.104.073924 [Abstract] [Full Text] [PDF]  

P. Heffeter, M. Pongratz, E. Steiner, P. Chiba, M. A. Jakupec, L. Elbling, B. Marian, W. Körner, F. Sevelda, M. Micksche, B. K. Keppler, and W. Berger

Intrinsic and Acquired Forms of Resistance against the Anticancer Ruthenium Compound KP1019 [Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A)
J Pharmacol Exp Ther 2005 312: 281-289. Published online August 26, 2004; 10.1124/jpet.104.073395 [Abstract] [Full Text] [PDF]  

Jan S. Moreb, Amir Gabr, Govind R. Vartikar, Santosh Gowda, James R. Zucali, and Dagmara Mohuczy

Retinoic Acid Down-Regulates Aldehyde Dehydrogenase and Increases Cytotoxicity of 4-Hydroperoxycyclophosphamide and Acetaldehyde
J Pharmacol Exp Ther 2005 312: 339-345. Published online October 6, 2004; 10.1124/jpet.104.072496 [Abstract] [Full Text] [PDF]  

Ulrike Puhlmann, Christina Ziemann, Gudrun Ruedell, Hagen Vorwerk, Dirk Schaefer, Claudia Langebrake, Peter Schuermann, Ursula Creutzig, and Dirk Reinhardt

Impact of the Cyclooxygenase System on Doxorubicin-Induced Functional Multidrug Resistance 1 Overexpression and Doxorubicin Sensitivity in Acute Myeloid Leukemic HL-60 Cells
J Pharmacol Exp Ther 2005 312: 346-354. Published online October 22, 2004; 10.1124/jpet.104.071571 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Thomas Marti, Øyvind Molberg, Qing Li, Gary M. Gray, Chaitan Khosla, and Ludvig M. Sollid

Prolyl Endopeptidase-Mediated Destruction of T Cell Epitopes in Whole Gluten: Chemical and Immunological Characterization
J Pharmacol Exp Ther 2005 312: 19-26. Published online September 9, 2004; 10.1124/jpet.104.073312 [Abstract] [Full Text] [PDF] [Supplemental Materials]   

Radoslav Coleski, Sutep Gonlachanvit, Chung Owyang, and William L. Hasler

Selective Reversal of Hyperglycemia-Evoked Gastric Myoelectric Dysrhythmias by Nitrergic Stimulation in Healthy Humans
J Pharmacol Exp Ther 2005 312: 103-111. Published online October 19, 2004; 10.1124/jpet.104.072868 [Abstract] [Full Text] [PDF]  

Hiroshi Yamasowa, Satoko Shimizu, Takao Inoue, Masanori Takaoka, and Yasuo Matsumura

Endothelial Nitric Oxide Contributes to the Renal Protective Effects of Ischemic Preconditioning
J Pharmacol Exp Ther 2005 312: 153-159. Published online August 12, 2004; 10.1124/jpet.104.074427 [Abstract] [Full Text] [PDF]  

Melissa K. Pulfer, Christian Taube, Erwin Gelfand, and Robert C. Murphy

Ozone Exposure in Vivo and Formation of Biologically Active Oxysterols in the Lung
J Pharmacol Exp Ther 2005 312: 256-264. Published online August 17, 2004; 10.1124/jpet.104.073437 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Michelle B. Crosby, John L. Svenson, John Zhang, Christopher J. Nicol, Frank J. Gonzalez, and Gary S. Gilkeson

Peroxisome Proliferation-Activated Receptor (PPAR) Is Not Necessary for Synthetic PPAR Agonist Inhibition of Inducible Nitric-Oxide Synthase and Nitric Oxide
J Pharmacol Exp Ther 2005 312: 69-76. Published online September 8, 2004; 10.1124/jpet.104.074005 [Abstract] [Full Text] [PDF]  

Thomas J. Connor, Andrew Harkin, and John P. Kelly

Methylenedioxymethamphetamine Suppresses Production of the Proinflammatory Cytokine Tumor Necrosis Factor- Independent of a -Adrenoceptor-Mediated Increase in Interleukin-10
J Pharmacol Exp Ther 2005 312: 134-143. Published online August 26, 2004; 10.1124/jpet.104.073023 [Abstract] [Full Text] [PDF]  

Mirentxu I. Iruretagoyena, Jaime A. Tobar, Pablo A. González, Sofía E. Sepúlveda, Claudio A. Figueroa, Rafael A. Burgos, Juan L. Hancke, and Alexis M. Kalergis

Andrographolide Interferes with T Cell Activation and Reduces Experimental Autoimmune Encephalomyelitis in the Mouse
J Pharmacol Exp Ther 2005 312: 366-372. Published online August 26, 2004; 10.1124/jpet.104.072512 [Abstract] [Full Text] [PDF]  

Patricia L. Podolin, James F. Callahan, Brian J. Bolognese, Yue H. Li, Karey Carlson, T. Gregg Davis, Geoff W. Mellor, Christopher Evans, and Amy K. Roshak

Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell Proliferation
J Pharmacol Exp Ther 2005 312: 373-381. Published online August 17, 2004; 10.1124/jpet.104.074484 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Shao-Rui Chen and Hui-Lin Pan

Distinct Roles of Group III Metabotropic Glutamate Receptors in Control of Nociception and Dorsal Horn Neurons in Normal and Nerve-Injured Rats
J Pharmacol Exp Ther 2005 312: 120-126. Published online September 16, 2004; 10.1124/jpet.104.073817 [Abstract] [Full Text] [PDF]  

David J. Eyerman and Bryan K. Yamamoto

Lobeline Attenuates Methamphetamine-Induced Changes in Vesicular Monoamine Transporter 2 Immunoreactivity and Monoamine Depletions in the Striatum
J Pharmacol Exp Ther 2005 312: 160-169. Published online August 26, 2004; 10.1124/jpet.104.072264 [Abstract] [Full Text] [PDF]  

Jerry J. Buccafusco, Jerry A. Davis, Laura C. Shuster, Christopher J. Buccafusco, and Mahanandeeshwar Gattu

The Importance of Brainstem Cholinergic Neurons in the Pressor Response to Cocaine
J Pharmacol Exp Ther 2005 312: 179-191. Published online August 24, 2004; 10.1124/jpet.104.073619 [Abstract] [Full Text] [PDF]  

Yulin Wang, Kang Tang, Saadet Inan, Daniel Siebert, Ulrike Holzgrabe, David Y.W. Lee, Peng Huang, Jian-Guo Li, Alan Cowan, and Lee-Yuan Liu-Chen

Comparison of Pharmacological Activities of Three Distinct Ligands (Salvinorin A, TRK-820 and 3FLB) on Opioid Receptors in Vitro and Their Antipruritic and Antinociceptive Activities in Vivo
J Pharmacol Exp Ther 2005 312: 220-230. Published online September 21, 2004; 10.1124/jpet.104.073668 [Abstract] [Full Text] [PDF]  

Layla Azam and J. Michael McIntosh

Effect of Novel -Conotoxins on Nicotine-Stimulated [³H]Dopamine Release from Rat Striatal Synaptosomes
J Pharmacol Exp Ther 2005 312: 231-237. Published online August 17, 2004; 10.1124/jpet.104.071456 [Abstract] [Full Text] [PDF]  

Elena Yablonsky-Alter, Eleonora Gashi, Theodore I. Lidsky, Hoau-Yan Wang, and Shailesh P. Banerjee

Clozapine Protection against Gestational Cocaine-Induced Neurochemical Abnormalities
J Pharmacol Exp Ther 2005 312: 297-302. Published online September 20, 2004; 10.1124/jpet.104.074062 [Abstract] [Full Text] [PDF]  

Jan K. Melichar, Susan P. Hume, Tim M. Williams, Mark R. C. Daglish, Lindsay G. Taylor, Rabia Ahmad, Andrea L. Malizia, David J. Brooks, Judith S. Myles, Anne Lingford-Hughes, and David J. Nutt

Using [¹¹C]Diprenorphine to Image Opioid Receptor Occupancy by Methadone in Opioid Addiction: Clinical and Preclinical Studies
J Pharmacol Exp Ther 2005 312: 309-315. Published online September 3, 2004; 10.1124/jpet.104.072686 [Abstract] [Full Text] [PDF]  

D. Bruce Vaupel, Srihari R. Tella, David L. Huso, Valentine O. Wagner, III, Alexey G. Mukhin, Svetlana I. Chefer, Andrew G. Horti, Edythe D. London, Andrei O. Koren, and Alane S. Kimes

Pharmacological and Toxicological Evaluation of 2-Fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a Ligand for Imaging Cerebral Nicotinic Acetylcholine Receptors with Positron Emission Tomography
J Pharmacol Exp Ther 2005 312: 355-365. Published online August 26, 2004; 10.1124/jpet.104.073999 [Abstract] [Full Text] [PDF]  

Thomas A. Lanz, Gregory J. Fici, and Kalpana M. Merchant

Lack of Specific Amyloid-(1-42) Suppression by Nonsteroidal Anti-Inflammatory Drugs in Young, Plaque-Free Tg2576 Mice and in Guinea Pig Neuronal Cultures
J Pharmacol Exp Ther 2005 312: 399-406. Published online August 30, 2004; 10.1124/jpet.104.073965 [Abstract] [Full Text] [PDF]  

Latchezar D. Todorov, Svetlana T. Mihaylova-Todorova, Sophie M. Choe, and David P. Westfall

Facilitation of the Purinergic Contractile Response of the Guinea Pig Vas Deferens by Sodium Orthovanadate
J Pharmacol Exp Ther 2005 312: 407-416. Published online October 22, 2004; 10.1124/jpet.104.072991 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Lin Wu, Jun Gu, Huadong Cui, Qing-Yu Zhang, Melissa Behr, Cheng Fang, Yan Weng, Kerri Kluetzman, Pamela J. Swiatek, Weizhu Yang, Laurence Kaminsky, and Xinxin Ding

Transgenic Mice with a Hypomorphic NADPH-Cytochrome P450 Reductase Gene: Effects on Development, Reproduction, and Microsomal Cytochrome P450
J Pharmacol Exp Ther 2005 312: 35-43. Published online August 24, 2004; 10.1124/jpet.104.073353 [Abstract] [Full Text] [PDF]  

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