ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Hsia-Lien Lin, Ute M. Kent, Haoming Zhang, Lucy Waskell, and Paul F. Hollenberg

The Functional Role of Threonine-205 in the Mechanism-Based Inactivation of P450 2B1 by Two Ethynyl Substrates: The Importance of the F Helix in Catalysis
J Pharmacol Exp Ther 2004 311: 855-863. Published online August 9, 2004; 10.1124/jpet.104.071670 [Abstract] [Full Text] [PDF]  

Hiromi Sakai, Yohei Masada, Hirohisa Horinouchi, Eiji Ikeda, Keitaro Sou, Shinji Takeoka, Makoto Suematsu, Masuhiko Takaori, Koichi Kobayashi, and Eishun Tsuchida

Physiological Capacity of the Reticuloendothelial System for the Degradation of Hemoglobin Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 Days
J Pharmacol Exp Ther 2004 311: 874-884. Published online August 5, 2004; 10.1124/jpet.104.073049 [Abstract] [Full Text] [PDF]  

Thomas M. Polasek, David J. Elliot, Benjamin C. Lewis, and John O. Miners

Mechanism-Based Inactivation of Human Cytochrome P4502C8 by Drugs in Vitro
J Pharmacol Exp Ther 2004 311: 996-1007. Published online August 10, 2004; 10.1124/jpet.104.071803 [Abstract] [Full Text] [PDF]  

Adam G. Staines, Michael W. H. Coughtrie, and Brian Burchell

N-Glucuronidation of Carbamazepine in Human Tissues Is Mediated by UGT2B7
J Pharmacol Exp Ther 2004 311: 1131-1137. Published online August 3, 2004; 10.1124/jpet.104.073114 [Abstract] [Full Text] [PDF]  

M. P. Schaddelee, D. Groenendaal, J. DeJongh, C. G. J. Cleypool, A. P. IJzerman, A. G. De Boer, and M. Danhof

Population Pharmacokinetic Modeling of Blood-Brain Barrier Transport of Synthetic Adenosine A₁ Receptor Agonists
J Pharmacol Exp Ther 2004 311: 1138-1146. Published online August 3, 2004; 10.1124/jpet.104.071308 [Abstract] [Full Text] [PDF]  

Ryota Kikuchi, Hiroyuki Kusuhara, Takaaki Abe, Hitoshi Endou, and Yuichi Sugiyama

Involvement of Multiple Transporters in the Efflux of 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors across the Blood-Brain Barrier
J Pharmacol Exp Ther 2004 311: 1147-1153. Published online August 3, 2004; 10.1124/jpet.104.071621 [Abstract] [Full Text] [PDF]  

Joseph R. Kurian, Sunil U. Bajad, Jackie L. Miller, Nathaniel A. Chin, and Lauren A. Trepanier

NADH Cytochrome b₅ Reductase and Cytochrome b₅ Catalyze the Microsomal Reduction of Xenobiotic Hydroxylamines and Amidoximes in Humans
J Pharmacol Exp Ther 2004 311: 1171-1178. Published online August 9, 2004; 10.1124/jpet.104.072389 [Abstract] [Full Text] [PDF]  

Hiroshi Takane, Daisuke Kobayashi, Takeshi Hirota, Junzo Kigawa, Naoki Terakawa, Kenji Otsubo, and Ichiro Ieiri

Haplotype-Oriented Genetic Analysis and Functional Assessment of Promoter Variants in the MDR1 (ABCB1) Gene
J Pharmacol Exp Ther 2004 311: 1179-1187. Published online July 27, 2004; 10.1124/jpet.104.069724 [Abstract] [Full Text] [PDF]  

Keith A. Hoffmaster, Maciej J. Zamek-Gliszczynski, Gary M. Pollack, and Kim L. R. Brouwer

Hepatobiliary Disposition of the Metabolically Stable Opioid Peptide [D-Pen², D-Pen⁵]-Enkephalin (DPDPE): Pharmacokinetic Consequences of the Interplay between Multiple Transport Systems
J Pharmacol Exp Ther 2004 311: 1203-1210. Published online August 9, 2004; 10.1124/jpet.104.070201 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Emily M. Jutkiewicz and Jack Bergman

Effects of Dopamine D₁ Ligands on Eye Blinking in Monkeys: Efficacy, Antagonism, and D₁/D₂ Interactions
J Pharmacol Exp Ther 2004 311: 1008-1015. Published online August 3, 2004; 10.1124/jpet.104.071092 [Abstract] [Full Text] [PDF]  

M. M. Hadjimarkou, A. Singh, Y. Kandov, Y. Israel, Y.-X. Pan, G. C. Rossi, G. W. Pasternak, and R. J. Bodnar

Opioid Receptor Involvement in Food Deprivation-Induced Feeding: Evaluation of Selective Antagonist and Antisense Oligodeoxynucleotide Probe Effects in Mice and Rats
J Pharmacol Exp Ther 2004 311: 1188-1202. Published online August 27, 2004; 10.1124/jpet.104.071761 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Luigi Sironi, Paolo Gelosa, Uliano Guerrini, Cristina Banfi, Veronica Crippa, Maura Brioschi, Elisabetta Gianazza, Elena Nobili, Anita Gianella, Marc de Gasparo, and Elena Tremoli

Anti-Inflammatory Effects of AT1 Receptor Blockade Provide End-Organ Protection in Stroke-Prone Rats Independently from Blood Pressure Fall
J Pharmacol Exp Ther 2004 311: 989-995. Published online August 9, 2004; 10.1124/jpet.104.072066 [Abstract] [Full Text] [PDF]  

Masataka Kuroda, Daisuke Yoshikawa, Koichi Nishikawa, Shigeru Saito, and Fumio Goto

Volatile Anesthetics Inhibit Calcitonin Gene-Related Peptide Receptor-Mediated Responses in Pithed Rats and Human Neuroblastoma Cells
J Pharmacol Exp Ther 2004 311: 1016-1022. Published online August 5, 2004; 10.1124/jpet.104.071936 [Abstract] [Full Text] [PDF]  

Marta Marchesi, Erin A. Booth, Treasa Davis, Charles L. Bisgaier, and Benedict R. Lucchesi

Apolipoprotein A-I_Milano and 1-Palmitoyl-2-oleoyl Phosphatidylcholine Complex (ETC-216) Protects the in Vivo Rabbit Heart from Regional Ischemia-Reperfusion Injury
J Pharmacol Exp Ther 2004 311: 1023-1031. Published online September 16, 2004; 10.1124/jpet.104.070789 [Abstract] [Full Text] [PDF]  

Yoko Takada, Masami Hashimoto, Jiro Kasahara, Kazuyuki Aihara, and Kohji Fukunaga

Cytoprotective Effect of Sodium Orthovanadate on Ischemia/Reperfusion-Induced Injury in the Rat Heart Involves Akt Activation and Inhibition of Fodrin Breakdown and Apoptosis
J Pharmacol Exp Ther 2004 311: 1249-1255. Published online August 3, 2004; 10.1124/jpet.104.070839 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Anshu K. Jain, Scott M. Moore, Kiyoshi Yamaguchi, Thomas E. Eling, and Seung Joon Baek

Selective Nonsteroidal Anti-Inflammatory Drugs Induce Thymosin -4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells
J Pharmacol Exp Ther 2004 311: 885-891. Published online August 3, 2004; 10.1124/jpet.104.070664 [Abstract] [Full Text] [PDF]  

Ji-Shi Wang, Fan Zhang, Miao Jiang, Mong-Heng Wang, Barbara A. Zand, Nader G. Abraham, Alberto Nasjletti, and Michal Laniado-Schwartzman

Transfection and Functional Expression of CYP4A1 and CYP4A2 Using Bicistronic Vectors in Vascular Cells and Tissues
J Pharmacol Exp Ther 2004 311: 913-920. Published online July 21, 2004; 10.1124/jpet.104.070979 [Abstract] [Full Text] [PDF]  

Masahiko Watabe and Toshio Nakaki

Rotenone Induces Apoptosis via Activation of Bad in Human Dopaminergic SH-SY5Y Cells
J Pharmacol Exp Ther 2004 311: 948-953. Published online July 27, 2004; 10.1124/jpet.104.071381 [Abstract] [Full Text] [PDF]  

Mariya Chhatriwala, R. Gnana Ravi, Roshni I. Patel, Jose L. Boyer, Kenneth A. Jacobson, and T. Kendall Harden

Induction of Novel Agonist Selectivity for the ADP-Activated P2Y₁ Receptor Versus the ADP-Activated P2Y₁₂ and P2Y₁₃ Receptors by Conformational Constraint of an ADP Analog
J Pharmacol Exp Ther 2004 311: 1038-1043. Published online September 2, 2004; 10.1124/jpet.104.068650 [Abstract] [Full Text] [PDF]  

Adrien Renaudo, Vanina Watry, Anne-Amandine Chassot, Gilles Ponzio, Jordi Ehrenfeld, and Olivier Soriani

Inhibition of Tumor Cell Proliferation by Ligands Is Associated with K⁺ Channel Inhibition and p27^kip1 Accumulation
J Pharmacol Exp Ther 2004 311: 1105-1114. Published online July 26, 2004; 10.1124/jpet.104.072413 [Abstract] [Full Text] [PDF]  

Sudhakar Misra, Karnam S. Murthy, Huiping Zhou, and John R. Grider

Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways
J Pharmacol Exp Ther 2004 311: 1154-1162. Published online August 12, 2004; 10.1124/jpet.104.071415 [Abstract] [Full Text] [PDF]  

S. W. Jones, D. J. Baker, S. M. Gardiner, T. Bennett, J. A. Timmons, and P. L. Greenhaff

The Effect of the ₂-Adrenoceptor Agonist Prodrug BRL-47672 on Cardiovascular Function, Skeletal Muscle Myosin Heavy Chain, and MyoD Expression in the Rat
J Pharmacol Exp Ther 2004 311: 1225-1231. Published online July 8, 2004; 10.1124/jpet.104.071589 [Abstract] [Full Text] [PDF]  

Matjaz Humar, Nikolaos Andriopoulos, Soeren E. Pischke, Torsten Loop, Rene Schmidt, Alexander Hoetzel, Martin Roesslein, Heike L. Pahl, Klaus K. Geiger, and Benedikt H. J. Pannen

Inhibition of Activator Protein 1 by Barbiturates Is Mediated by Differential Effects on Mitogen-Activated Protein Kinases and the Small G Proteins Ras and Rac-1
J Pharmacol Exp Ther 2004 311: 1232-1240. Published online July 19, 2004; 10.1124/jpet.104.071332 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

M. Nouzova, N. Holtan, M. M. Oshiro, R. B. Isett, J. L. Munoz-Rodriguez, A. F. List, M. L. Narro, S. J. Miller, N. C. Merchant, and B. W. Futscher

Epigenomic Changes during Leukemia Cell Differentiation: Analysis of Histone Acetylation and Cytosine Methylation Using CpG Island Microarrays
J Pharmacol Exp Ther 2004 311: 968-981. Published online August 9, 2004; 10.1124/jpet.104.072488 [Abstract] [Full Text] [PDF]  

Takashi Nozawa, Masato Suzuki, Koichi Takahashi, Hikaru Yabuuchi, Tomoji Maeda, Akira Tsuji, and Ikumi Tamai

Involvement of Estrone-3-Sulfate Transporters in Proliferation of Hormone-Dependent Breast Cancer Cells
J Pharmacol Exp Ther 2004 311: 1032-1037. Published online August 24, 2004; 10.1124/jpet.104.071522 [Abstract] [Full Text] [PDF]  

Jee Hyun Um, Joong Keun Kwon, Chi-Dug Kang, Mi Ju Kim, Dong Sik Ju, Jae Ho Bae, Dong Wan Kim, Byung Seon Chung, and Sun Hee Kim

Relationship between Antiapoptotic Molecules and Metastatic Potency and the Involvement of DNA-Dependent Protein Kinase in the Chemosensitization of Metastatic Human Cancer Cells by Epidermal Growth Factor Receptor Blockade
J Pharmacol Exp Ther 2004 311: 1062-1070. Published online July 23, 2004; 10.1124/jpet.104.070938 [Abstract] [Full Text] [PDF]  

Stephanie L. Matheson, James P. McNamee, Taiqui Wang, Moulay A. Alaoui-Jamali, Ana M. Tari, and Bertrand J. Jean-Claude

The Combi-Targeting Concept: Dissection of the Binary Mechanism of Action of the Combi-Triazene SMA41 in Vitro and Antitumor Activity in Vivo
J Pharmacol Exp Ther 2004 311: 1163-1170. Published online September 9, 2004; 10.1124/jpet.104.071977 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Takehiko Uesugi, Matthias Froh, Erwin Gäbele, Fuyumi Isayama, Blair U. Bradford, Iwao Ikai, Yoshio Yamaoka, and Gavin E. Arteel

Contribution of Angiotensin II to Alcohol-Induced Pancreatic Fibrosis in Rats
J Pharmacol Exp Ther 2004 311: 921-928. Published online August 17, 2004; 10.1124/jpet.104.071324 [Abstract] [Full Text] [PDF]  

Andrew J. Hirsh, Juan R. Sabater, Andra Zamurs, Rick T. Smith, Anthony M. Paradiso, Sam Hopkins, William M. Abraham, and Richard C. Boucher

Evaluation of Second Generation Amiloride Analogs as Therapy for Cystic Fibrosis Lung Disease
J Pharmacol Exp Ther 2004 311: 929-938. Published online July 23, 2004; 10.1124/jpet.104.071886 [Abstract] [Full Text] [PDF]  

Xiaoming Deng, Sandor Szabo, Tetyana Khomenko, Martin R. Jadus, and Masashi Yoshida

Gene Therapy with Adenoviral Plasmids or Naked DNA of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Accelerates Healing of Duodenal Ulcer in Rats
J Pharmacol Exp Ther 2004 311: 982-988. Published online August 9, 2004; 10.1124/jpet.104.071464 [Abstract] [Full Text] [PDF]  

Prajakta A. Sonalker, Stevan P. Tofovic, and Edwin K. Jackson

Increased Expression of the Sodium Transporter BSC-1 in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2004 311: 1052-1061. Published online August 30, 2004; 10.1124/jpet.104.071209 [Abstract] [Full Text] [PDF]  

Julia Pinsonneault, Carsten Uhd Nielsen, and Wolfgang Sadée

Genetic Variants of the Human H⁺/Dipeptide Transporter PEPT2: Analysis of Haplotype Functions
J Pharmacol Exp Ther 2004 311: 1088-1096. Published online July 28, 2004; 10.1124/jpet.104.073098 [Abstract] [Full Text] [PDF]  

Xueying Zhao, John R. Falck, V. Raj Gopal, Edward W. Inscho, and John D. Imig

P2X Receptor-Stimulated Calcium Responses in Preglomerular Vascular Smooth Muscle Cells Involves 20-Hydroxyeicosatetraenoic Acid
J Pharmacol Exp Ther 2004 311: 1211-1217. Published online August 17, 2004; 10.1124/jpet.104.070797 [Abstract] [Full Text] [PDF]  

Stefano Fiorucci, Annarita Di Lorenzo, Barbara Renga, Silvana Farneti, Antonio Morelli, and Giuseppe Cirino

Nitric Oxide (NO)-Releasing Naproxen (HCT-3012 [(S)-6-Methoxy--methyl-2-naphthaleneacetic Acid 4-(Nitrooxy)butyl Ester]) Interactions with Aspirin in Gastric Mucosa of Arthritic Rats Reveal a Role for Aspirin-Triggered Lipoxin, Prostaglandins, and NO in Gastric Protection
J Pharmacol Exp Ther 2004 311: 1264-1271. Published online August 5, 2004; 10.1124/jpet.104.072843 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Richard R. Harris, Lawrence Black, Sekhar Surapaneni, Teodozyj Kolasa, Sandra Majest, Marian T. Namovic, George Grayson, Victoria Komater, Denise Wilcox, Linda King, Kennan Marsh, Michael F. Jarvis, Merrill Nuss, Hugh Nellans, Lee Pruesser, Glenn A. Reinhart, Bryan Cox, Peer Jacobson, Andrew Stewart, Michael Coghlan, George Carter, and Randy L. Bell

ABT-963 [2-(3,4-Difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], A Highly Potent and Selective Disubstituted Pyridazinone Cyclooxgenase-2 Inhibitor
J Pharmacol Exp Ther 2004 311: 904-912. Published online July 26, 2004; 10.1124/jpet.104.070052 [Abstract] [Full Text] [PDF]  

Guillaume Morissette, Jean-Philippe Fortin, Sophie Otis, Johanne Bouthillier, and François Marceau

A Novel Nonpeptide Antagonist of the Kinin B₁ Receptor: Effects at the Rabbit Receptor
J Pharmacol Exp Ther 2004 311: 1121-1130. Published online July 26, 2004; 10.1124/jpet.104.071266 [Abstract] [Full Text] [PDF]  

Koh-ichi Yuhki, Akinori Ueno, Hiroaki Naraba, Fumiaki Kojima, Fumitaka Ushikubi, Shuh Narumiya, and Sachiko Oh-ishi

Prostaglandin Receptors EP2, EP3, and IP Mediate Exudate Formation in Carrageenin-Induced Mouse Pleurisy
J Pharmacol Exp Ther 2004 311: 1218-1224. Published online August 17, 2004; 10.1124/jpet.104.071548 [Abstract] [Full Text] [PDF]  

Ylenia Suzuki, Emanuela Masini, Cosimo Mazzocca, Salvatore Cuzzocrea, Anna Ciampa, Hisanori Suzuki, and Daniele Bani

Inhibition of Poly(ADP-Ribose) Polymerase Prevents Allergen-Induced Asthma-Like Reaction in Sensitized Guinea Pigs
J Pharmacol Exp Ther 2004 311: 1241-1248. Published online July 13, 2004; 10.1124/jpet.104.072546 [Abstract] [Full Text] [PDF]  

Hiroyuki Iwamura, Motohide Sato, and Korekiyo Wakitani

Comparative Study of Glucocorticoids, Cyclosporine A, and JTE-607 [(-)-Ethyl-N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-L-phenylalaninate Dihydrochloride] in a Mouse Septic Shock Model
J Pharmacol Exp Ther 2004 311: 1256-1263. Published online July 27, 2004; 10.1124/jpet.104.072421 [Abstract] [Full Text] [PDF]  

Salvatore Cuzzocrea, Emanuela Mazzon, Rosanna Di Paola, Nimesh S. A. Patel, Tiziana Genovese, Carmelo Muià, Angelina De Sarro, and Christoph Thiemermann

Erythropoietin Reduces the Development of Experimental Inflammatory Bowel Disease
J Pharmacol Exp Ther 2004 311: 1272-1280. Published online August 9, 2004; 10.1124/jpet.104.073197 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Zi-Zhen Wu, Shao-Rui Chen, and Hui-Lin Pan

Differential Sensitivity of N- and P/Q-Type Ca²+ Channel Currents to a µ Opioid in Isolectin B -Positive and -Negative Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther 2004 311: 939-947. Published online July 27, 2004; 10.1124/jpet.104.073429 [Abstract] [Full Text] [PDF]  

Miguel Díaz-Hernández, Jesús Sánchez-Nogueiro, Jesús Pintor, and M. Teresa Miras-Portugal

Interaction between Dinucleotide and Nicotinic Receptors in Individual Cholinergic Terminals
J Pharmacol Exp Ther 2004 311: 954-967. Published online July 13, 2004; 10.1124/jpet.104.072249 [Abstract] [Full Text] [PDF]  

L. Kantor, M. Zhang, B. Guptaroy, Y. H. Park, and M. E. Gnegy

Repeated Amphetamine Couples Norepinephrine Transporter and Calcium Channel Activities in PC12 Cells
J Pharmacol Exp Ther 2004 311: 1044-1051. Published online August 30, 2004; 10.1124/jpet.104.071068 [Abstract] [Full Text] [PDF]  

Donald W. Floyd, David P. Friedman, James B. Daunais, Peter J. Pierre, Kathleen A. Grant, and Brian A. McCool

Long-Term Ethanol Self-Administration by Cynomolgus Macaques Alters the Pharmacology and Expression of GABA_A Receptors in Basolateral Amygdala
J Pharmacol Exp Ther 2004 311: 1071-1079. Published online July 27, 2004; 10.1124/jpet.104.072025 [Abstract] [Full Text] [PDF]  

C. Demougeot, M. Van Hoecke, N. Bertrand, A. Prigent-Tessier, C. Mossiat, A. Beley, and C. Marie

Cytoprotective Efficacy and Mechanisms of the Liposoluble Iron Chelator 2,2'-Dipyridyl in the Rat Photothrombotic Ischemic Stroke Model
J Pharmacol Exp Ther 2004 311: 1080-1087. Published online July 27, 2004; 10.1124/jpet.104.072744 [Abstract] [Full Text] [PDF]  

Anne M. Heacock, Daniel Kerley, Grzegorz T. Gurda, Aaron T. VanTroostenberghe, and Stephen K. Fisher

Potentiation of the Osmosensitive Release of Taurine and D-Aspartate from SH-SY5Y Neuroblastoma Cells after Activation of M₃ Muscarinic Cholinergic Receptors
J Pharmacol Exp Ther 2004 311: 1097-1104. Published online August 3, 2004; 10.1124/jpet.104.072553 [Abstract] [Full Text] [PDF]  

V. Monnaert, D. Betbeder, L. Fenart, H. Bricout, A. M. Lenfant, C. Landry, R. Cecchelli, E. Monflier, and S. Tilloy

Effects of - and Hydroxypropyl--cyclodextrins on the Transport of Doxorubicin across an in Vitro Model of Blood-Brain Barrier
J Pharmacol Exp Ther 2004 311: 1115-1120. Published online July 27, 2004; 10.1124/jpet.104.071845 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Tanya C. McCarthy, P. Timothy Pollak, Elyisha A. Hanniman, and Christopher J. Sinal

Disruption of Hepatic Lipid Homeostasis in Mice after Amiodarone Treatment Is Associated with Peroxisome Proliferator-Activated Receptor-Target Gene Activation
J Pharmacol Exp Ther 2004 311: 864-873. Published online July 20, 2004; 10.1124/jpet.104.072785 [Abstract] [Full Text] [PDF]  

Raoef Imamdi, Marjo de Graauw, and Bob van de Water

Protein Kinase C Mediates Cisplatin-Induced Loss of Adherens Junctions Followed by Apoptosis of Renal Proximal Tubular Epithelial Cells
J Pharmacol Exp Ther 2004 311: 892-903. Published online September 20, 2004; 10.1124/jpet.104.072678 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "p53-Dependent Apoptotic Mechanism of a New Designer Bimetallic Compound Tri-phenyl Tin Benzimidazolethiol Copper Chloride (TPT-CuCl₂): In Vivo Studies in Wistar Rats as Well as in Vitro Studies in Human Cervical Cancer Cells"
J Pharmacol Exp Ther 2004 311: 1281. [Full Text] [PDF]  

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