PERSPECTIVES IN PHARMACOLOGY:

Stephen C. Heinrichs and George F. Koob

Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation
J Pharmacol Exp Ther 2004 311: 427-440. Published online August 5, 2004; 10.1124/jpet.103.052092 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Yan Zhang, John D. Schuetz, William F. Elmquist, and Donald W. Miller

Plasma Membrane Localization of Multidrug Resistance-Associated Protein Homologs in Brain Capillary Endothelial Cells
J Pharmacol Exp Ther 2004 311: 449-455. Published online June 24, 2004; 10.1124/jpet.104.068528 [Abstract] [Full Text] [PDF]  

Merlin C. Thomas, Christos Tikellis, Phillip Kantharidis, Wendy C. Burns, Mark E. Cooper, and Josephine M. Forbes

The Role of Advanced Glycation in Reduced Organic Cation Transport Associated with Experimental Diabetes
J Pharmacol Exp Ther 2004 311: 456-466. Published online June 22, 2004; 10.1124/jpet.104.070672 [Abstract] [Full Text] [PDF]  

Hannah M. Prime-Chapman, Richard A. Fearn, Anne E. Cooper, Vanessa Moore, and Barry H. Hirst

Differential Multidrug Resistance-Associated Protein 1 through 6 Isoform Expression and Function in Human Intestinal Epithelial Caco-2 Cells
J Pharmacol Exp Ther 2004 311: 476-484. Published online June 21, 2004; 10.1124/jpet.104.068775 [Abstract] [Full Text] [PDF]  

Michael J. Avram, Tom C. Krejcie, Thomas K. Henthorn, and Claus U. Niemann

-Adrenergic Blockade Affects Initial Drug Distribution Due to Decreased Cardiac Output and Altered Blood Flow Distribution
J Pharmacol Exp Ther 2004 311: 617-624. Published online June 14, 2004; 10.1124/jpet.104.070094 [Abstract] [Full Text] [PDF]  

Banmeet S. Anand, Suresh Katragadda, and Ashim K. Mitra

Pharmacokinetics of Novel Dipeptide Ester Prodrugs of Acyclovir after Oral Administration: Intestinal Absorption and Liver Metabolism
J Pharmacol Exp Ther 2004 311: 659-667. Published online June 29, 2004; 10.1124/jpet.104.069997 [Abstract] [Full Text] [PDF]  

Eric T. Williams, Malgorzata Leyk, Steven A. Wrighton, Peter J. A. Davies, David S. Loose, Gregory L. Shipley, and Henry W. Strobel

Estrogen Regulation of the Cytochrome P450 3A Subfamily in Humans
J Pharmacol Exp Ther 2004 311: 728-735. Published online July 28, 2004; 10.1124/jpet.104.068908 [Abstract] [Full Text] [PDF] Data Supplements  

Jatinder K. Lamba, Vishal Lamba, Kazuto Yasuda, Yvonne S. Lin, Mahfoud Assem, Emma Thompson, Stephen Strom, and Erin Schuetz

Expression of Constitutive Androstane Receptor Splice Variants in Human Tissues and Their Functional Consequences
J Pharmacol Exp Ther 2004 311: 811-821. Published online June 11, 2004; 10.1124/jpet.104.069310 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Aron H. Lichtman, Donmienne Leung, Christopher C. Shelton, Alan Saghatelian, Christophe Hardouin, Dale L. Boger, and Benjamin F. Cravatt

Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity
J Pharmacol Exp Ther 2004 311: 441-448. Published online June 30, 2004; 10.1124/jpet.104.069401 [Abstract] [Full Text] [PDF]  

Alexander R. Kosowski and Sture Liljequist

The NR2B-Selective N-Methyl-D-aspartate Receptor Antagonist Ro 25-6981 [(±)-(R*,S*)--(4-Hydroxyphenyl)--methyl-4-(phenylmethyl)-1-piperidine Propanol] Potentiates the Effect of Nicotine on Locomotor Activity and Dopamine Release in the Nucleus Accumbens
J Pharmacol Exp Ther 2004 311: 560-567. Published online July 15, 2004; 10.1124/jpet.104.070235 [Abstract] [Full Text] [PDF]  

Matthew D. Recker and Guy A. Higgins

The Opioid Receptor Like-1 Receptor Agonist Ro 64-6198 (1S,3aS-8-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one) Produces a Discriminative Stimulus in Rats Distinct from That of a µ, , and Opioid Receptor Agonist Cue
J Pharmacol Exp Ther 2004 311: 652-658. Published online June 29, 2004; 10.1124/jpet.104.071423 [Abstract] [Full Text] [PDF]  

Rimante Minkeviciene, Pradeep Banerjee, and Heikki Tanila

Memantine Improves Spatial Learning in a Transgenic Mouse Model of Alzheimer's Disease
J Pharmacol Exp Ther 2004 311: 677-682. Published online June 10, 2004; 10.1124/jpet.104.071027 [Abstract] [Full Text] [PDF]  

Paul W. Czoty, Chinnasamy R. Ramanathan, Nicole H. Mutschler, Alexandros Makriyannis, and Jack Bergman

Drug Discrimination in Methamphetamine-Trained Monkeys: Effects of Monoamine Transporter Inhibitors
J Pharmacol Exp Ther 2004 311: 720-727. Published online July 7, 2004; 10.1124/jpet.104.071035 [Abstract] [Full Text] [PDF]  

Albert Hsu, Daniel M. Togasaki, Erwan Bezard, Pierre Sokoloff, J. William Langston, Donato A. Di Monte, and Maryka Quik

Effect of the D3 Dopamine Receptor Partial Agonist BP897 [N-[4-(4-(2-Methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-Dihydroxyphenylalanine-Induced Dyskinesias and Parkinsonism in Squirrel Monkeys
J Pharmacol Exp Ther 2004 311: 770-777. Published online June 29, 2004; 10.1124/jpet.104.071142 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Yves Rival, Aline Stennevin, Laurence Puech, Anne Rouquette, Claudie Cathala, Fabrice Lestienne, Elisabeth Dupont-Passelaigue, Jean-François Patoiseau, Thierry Wurch, and Didier Junquéro

Human Adipocyte Fatty Acid-Binding Protein (aP2) Gene Promoter-Driven Reporter Assay Discriminates Nonlipogenic Peroxisome Proliferator-Activated Receptor Ligands
J Pharmacol Exp Ther 2004 311: 467-475. Published online July 23, 2004; 10.1124/jpet.104.068254 [Abstract] [Full Text] [PDF]  

Pál Pacher, Anne Vaslin, Rita Benko, Jon G. Mabley, Lucas Liaudet, György Haskó, Anita Marton, Sándor Bátkai, Márk Kollai, and Csaba Szabó

A New, Potent Poly(ADP-ribose) Polymerase Inhibitor Improves Cardiac and Vascular Dysfunction Associated with Advanced Aging
J Pharmacol Exp Ther 2004 311: 485-491. Published online June 22, 2004; 10.1124/jpet.104.069658 [Abstract] [Full Text] [PDF]  

Marvin T. Nieman, Mark Warnock, Ahmed A. K. Hasan, Fakhri Mahdi, Benedict R. Lucchesi, Nancy J. Brown, Laine J. Murphey, and Alvin H. Schmaier

The Preparation and Characterization of Novel Peptide Antagonists to Thrombin and Factor VIIa and Activation of Protease-Activated Receptor 1
J Pharmacol Exp Ther 2004 311: 492-501. Published online June 21, 2004; 10.1124/jpet.104.069229 [Abstract] [Full Text] [PDF]  

Sachin A. Gupte, Elias A. Zias, Mohan R. Sarabu, and Michael S. Wolin

Role of Prostaglandins in Mediating Differences in Human Internal Mammary and Radial Artery Relaxation Elicited by Hypoxia
J Pharmacol Exp Ther 2004 311: 510-518. Published online June 30, 2004; 10.1124/jpet.104.070995 [Abstract] [Full Text] [PDF]  

Heleni Loutrari, Maria Hatziapostolou, Vassoula Skouridou, Evangelia Papadimitriou, Charis Roussos, Fragiskos N. Kolisis, and Andreas Papapetropoulos

Perillyl Alcohol Is an Angiogenesis Inhibitor
J Pharmacol Exp Ther 2004 311: 568-575. Published online June 21, 2004; 10.1124/jpet.104.070516 [Abstract] [Full Text] [PDF]  

Vishnu Chintalgattu and Laxmansa C. Katwa

Role of Protein Kinase C in Endothelin-Induced Type I Collagen Expression in Cardiac Myofibroblasts Isolated from the Site of Myocardial Infarction
J Pharmacol Exp Ther 2004 311: 691-699. Published online July 7, 2004; 10.1124/jpet.104.070151 [Abstract] [Full Text] [PDF]  

Jane McHowat, Luther M. Swift, Kimberly N. Crown, and Narine A. Sarvazyan

Changes in Phospholipid Content and Myocardial Calcium-Independent Phospholipase A₂ Activity during Chronic Anthracycline Administration
J Pharmacol Exp Ther 2004 311: 736-741. Published online August 4, 2004; 10.1124/jpet.104.069419 [Abstract] [Full Text] [PDF]  

Richard E. Roberts

The Role of Rho Kinase and Extracellular Regulated Kinase-Mitogen-Activated Protein Kinase in ₂-Adrenoceptor-Mediated Vasoconstriction in the Porcine Palmar Lateral Vein
J Pharmacol Exp Ther 2004 311: 742-747. Published online July 1, 2004; 10.1124/jpet.104.071100 [Abstract] [Full Text] [PDF]  

Candace Lee, Neeraj S. Visen, Naranjan S. Dhalla, Hoa Dinh Le, Michael Isaac, Platon Choptiany, Gil Gross, Alexander Omelchenko, Toshio Matsuda, Akemichi Baba, Kenzo Takahashi, Mark Hnatowich, and Larry V. Hryshko

Inhibitory Profile of SEA0400 [2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline] Assessed on the Cardiac Na⁺-Ca²⁺ Exchanger, NCX1.1
J Pharmacol Exp Ther 2004 311: 748-757. Published online July 1, 2004; 10.1124/jpet.104.070805 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Atsushi Fukunari, Ken Okamoto, Takeshi Nishino, Bryan T. Eger, Emil F. Pai, Miho Kamezawa, Ichimaro Yamada, and Norihisa Kato

Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion
J Pharmacol Exp Ther 2004 311: 519-528. Published online June 9, 2004; 10.1124/jpet.104.070433 [Abstract] [Full Text] [PDF]  

Alison J. Smith, Beth Oxley, Sallie Malpas, Gopalan V. Pillai, and Peter B. Simpson

Compounds Exhibiting Selective Efficacy for Different Subunits of Human Recombinant -Aminobutyric Acid_A Receptors
J Pharmacol Exp Ther 2004 311: 601-609. Published online June 21, 2004; 10.1124/jpet.104.070342 [Abstract] [Full Text] [PDF]  

Mark W. Poustie, John Carran, Kevin McEleney, S. Jeffrey Dixon, Tassos P. Anastassiades, and Suzanne M. Bernier

N-Butyryl Glucosamine Increases Matrix Gene Expression by Chondrocytes
J Pharmacol Exp Ther 2004 311: 610-616. Published online July 7, 2004; 10.1124/jpet.104.067769 [Abstract] [Full Text] [PDF]  

Nobuhisa Tanaka, Takao Morita, Akihiro Nezu, Akihiko Tanimura, Itaru Mizoguchi, and Yosuke Tojyo

Signaling Mechanisms Involved in Protease-Activated Receptor-1-Mediated Interleukin-6 Production by Human Gingival Fibroblasts
J Pharmacol Exp Ther 2004 311: 778-786. Published online June 21, 2004; 10.1124/jpet.104.068569 [Abstract] [Full Text] [PDF]  

Barbara Tolloczko, Petra Turkewitsch, Mustafa Al-Chalabi, and James G. Martin

LY-294002 [2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] Affects Calcium Signaling in Airway Smooth Muscle Cells Independently of Phosphoinositide 3-Kinase Inhibition
J Pharmacol Exp Ther 2004 311: 787-793. Published online June 11, 2004; 10.1124/jpet.104.069013 [Abstract] [Full Text] [PDF]  

Aarti N. Desai, Kelly M. Standifer, and Douglas C. Eikenburg

Simultaneous _2B- and ₂-Adrenoceptor Activation Sensitizes the _2B-Adrenoceptor for Agonist-Induced Down-Regulation
J Pharmacol Exp Ther 2004 311: 794-802. Published online June 10, 2004; 10.1124/jpet.104.069674 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Flavio F. Solca, Anke Baum, Elke Langkopf, Georg Dahmann, Karl-Heinz Heider, Frank Himmelsbach, and Jacques C. A. van Meel

Inhibition of Epidermal Growth Factor Receptor Activity by Two Pyrimidopyrimidine Derivatives
J Pharmacol Exp Ther 2004 311: 502-509. Published online June 15, 2004; 10.1124/jpet.104.069138 [Abstract] [Full Text] [PDF]  

Bernd Kaina, Ute Mühlhausen, Andrea Piee-Staffa, Markus Christmann, Regine Garcia Boy, Frank Rösch, and Ralf Schirrmacher

Inhibition of O⁶-Methylguanine-DNA Methyltransferase by Glucose-Conjugated Inhibitors: Comparison with Nonconjugated Inhibitors and Effect on Fotemustine and Temozolomide-Induced Cell Death
J Pharmacol Exp Ther 2004 311: 585-593. Published online July 13, 2004; 10.1124/jpet.104.071316 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Donald E. Mager, Darrell R. Abernethy, Josephine M. Egan, and Dariush Elahi

Exendin-4 Pharmacodynamics: Insights from the Hyperglycemic Clamp Technique
J Pharmacol Exp Ther 2004 311: 830-835. Published online June 15, 2004; 10.1124/jpet.104.069765 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

César Menor, María D. Fernández-Moreno, Jesús A. Fueyo, Oscar Escribano, Tomás Olleros, Encarna Arriaza, Carlos Cara, Michele Lorusso, Marco Di Paola, Irene D. Román, and Luis G. Guijarro

Azathioprine Acts upon Rat Hepatocyte Mitochondria and Stress-Activated Protein Kinases Leading to Necrosis: Protective Role of N-Acetyl-L-cysteine
J Pharmacol Exp Ther 2004 311: 668-676. Published online June 28, 2004; 10.1124/jpet.104.069286 [Abstract] [Full Text] [PDF]  

Daniel Y. Hung, Gerhard A. Siebert, Ping Chang, Yuri G. Anissimov, and Michael S. Roberts

Disposition Kinetics of Propranolol Isomers in the Perfused Rat Liver
J Pharmacol Exp Ther 2004 311: 822-829. Published online June 10, 2004; 10.1124/jpet.104.070011 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Kerryn McCluskie, Mark A. Birrell, Sissie Wong, and Maria G. Belvisi

Nitric Oxide as a Noninvasive Biomarker of Lipopolysaccharide-Induced Airway Inflammation: Possible Role in Lung Neutrophilia
J Pharmacol Exp Ther 2004 311: 625-633. Published online June 29, 2004; 10.1124/jpet.104.068890 [Abstract] [Full Text] [PDF]  

Cheryl E. Rockwell and Norbert E. Kaminski

A Cyclooxygenase Metabolite of Anandamide Causes Inhibition of Interleukin-2 Secretion in Murine Splenocytes
J Pharmacol Exp Ther 2004 311: 683-690. Published online July 29, 2004; 10.1124/jpet.104.065524 [Abstract] [Full Text] [PDF]  

Ashley A. Frazer-Abel, Shairaz Baksh, Susan P. Fosmire, Derall Willis, Angela M. Pierce, Heather Meylemans, Darwin S. Linthicum, Steven J. Burakoff, Teresa Coons, Donald Bellgrau, and Jaime F. Modiano

Nicotine Activates Nuclear Factor of Activated T Cells c2 (NFATc2) and Prevents Cell Cycle Entry in T Cells
J Pharmacol Exp Ther 2004 311: 758-769. Published online July 1, 2004; 10.1124/jpet.104.070060 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Shu-Cheng Chen, Tsui-Jung Chang, and Fong-Sen Wu

Competitive Inhibition of the Capsaicin Receptor-Mediated Current by Dehydroepiandrosterone in Rat Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther 2004 311: 529-536. Published online June 16, 2004; 10.1124/jpet.104.069096 [Abstract] [Full Text] [PDF]  

Susan K. Sullivan, Robert E. Petroski, Gail Verge, Raymond S. Gross, Alan C. Foster, and Dimitri E. Grigoriadis

Characterization of the Interaction of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic, with the GABA_A Receptor
J Pharmacol Exp Ther 2004 311: 537-546. Published online July 15, 2004; 10.1124/jpet.104.071282 [Abstract] [Full Text] [PDF]  

Alan C. Foster, Mary Ann Pelleymounter, Mary Jane Cullen, Dacie Lewis, Margaret Joppa, Ta Kung Chen, Haig P. Bozigian, Raymond S. Gross, and Kathleen R. Gogas

In Vivo Pharmacological Characterization of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic
J Pharmacol Exp Ther 2004 311: 547-559. Published online July 15, 2004; 10.1124/jpet.103.063487 [Abstract] [Full Text] [PDF]  

Smriti Iyengar, Amy A. Webster, Susan K. Hemrick-Luecke, Jimmy Yu Xu, and Rosa Maria A. Simmons

Efficacy of Duloxetine, a Potent and Balanced Serotonin-Norepinephrine Reuptake Inhibitor in Persistent Pain Models in Rats
J Pharmacol Exp Ther 2004 311: 576-584. Published online July 13, 2004; 10.1124/jpet.104.070656 [Abstract] [Full Text] [PDF]  

Marvin E. Myles, Ann M. Azcuy, Ngoc T. Nguyen, Eric R. Reisch, Steven A. Barker, Hilary W. Thompson, and James M. Hill

Bupropion (Zyban, Wellbutrin) Inhibits Nicotine-Induced Viral Reactivation in Herpes Simplex Virus Type 1 Latent Rabbits
J Pharmacol Exp Ther 2004 311: 640-644. Published online July 13, 2004; 10.1124/jpet.104.070862 [Abstract] [Full Text] [PDF]  

Lih-Chu Chiou, Kuang-Chieh Chuang, Juergen Wichmann, and Geo Adam

Ro 64-6198 [(1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one] Acts Differently from Nociceptin/Orphanin FQ in Rat Periaqueductal Gray Slices
J Pharmacol Exp Ther 2004 311: 645-651. Published online July 13, 2004; 10.1124/jpet.104.070219 [Abstract] [Full Text] [PDF]  

L. E. O'Dell and L. H. Parsons

Serotonin_1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels
J Pharmacol Exp Ther 2004 311: 711-719. Published online June 28, 2004; 10.1124/jpet.104.069278 [Abstract] [Full Text] [PDF]  

Takeshi Tanimoto, Mamoru Takeda, Toshimi Nishikawa, and Shigeji Matsumoto

The Role of 5-Hydroxytryptamine₃ Receptors in the Vagal Afferent Activation-Induced Inhibition of the First Cervical Dorsal Horn Spinal Neurons Projected from Tooth Pulp in the Rat
J Pharmacol Exp Ther 2004 311: 803-810. Published online June 23, 2004; 10.1124/jpet.104.070300 [Abstract] [Full Text] [PDF]  

Hiroshi Katsuki, Miki Nonaka, Hisashi Shirakawa, Toshiaki Kume, and Akinori Akaike

Endogenous D-Serine Is Involved in Induction of Neuronal Death by N-Methyl-D-aspartate and Simulated Ischemia in Rat Cerebrocortical Slices
J Pharmacol Exp Ther 2004 311: 836-844. Published online July 7, 2004; 10.1124/jpet.104.070912 [Abstract] [Full Text] [PDF]  

Rui E. Castro, Susana Solá, Rita M. Ramalho, Clifford J. Steer, and Cecília M. P. Rodrigues

The Bile Acid Tauroursodeoxycholic Acid Modulates Phosphorylation and Translocation of Bad via Phosphatidylinositol 3-Kinase in Glutamate-Induced Apoptosis of Rat Cortical Neurons
J Pharmacol Exp Ther 2004 311: 845-852. Published online June 9, 2004; 10.1124/jpet.104.070532 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Naoya Matsunaga, Naomi Nakamura, Noriyo Yoneda, Tian Qin, Hideyuki Terazono, Hideto To, Shun Higuchi, and Shigehiro Ohdo

Influence of Feeding Schedule on 24-h Rhythm of Hepatotoxicity Induced by Acetaminophen in Mice
J Pharmacol Exp Ther 2004 311: 594-600. Published online June 17, 2004; 10.1124/jpet.104.069062 [Abstract] [Full Text] [PDF]  

Jean-Claude Lavoie, Thérèse Rouleau, and Philippe Chessex

Interaction between Ascorbate and Light-Exposed Riboflavin Induces Lung Remodeling
J Pharmacol Exp Ther 2004 311: 634-639. Published online July 13, 2004; 10.1124/jpet.104.070755 [Abstract] [Full Text] [PDF]  

Maria F. M. Braga, Edna F. R. Pereira, Arpad Mike, and Edson X. Albuquerque

Pb²⁺ via Protein Kinase C Inhibits Nicotinic Cholinergic Modulation of Synaptic Transmission in the Hippocampus
J Pharmacol Exp Ther 2004 311: 700-710. Published online June 28, 2004; 10.1124/jpet.104.070466 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung"
J Pharmacol Exp Ther 2004 311: 853. [Full Text] [PDF]  

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