ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Eric Y. Zhang, Dong-Jing Fu, Youngeen A. Pak, Trent Stewart, Nitai Mukhopadhyay, Steven A. Wrighton, and Kathleen M. Hillgren

Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro⁵⁸⁶
J Pharmacol Exp Ther 2004 310: 437-445. Published online April 9, 2004; 10.1124/jpet.104.065912 [Abstract] [Full Text] [PDF] Data Supplement  

Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley, and William F. Bosron

Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
J Pharmacol Exp Ther 2004 310: 469-476. Published online April 13, 2004; 10.1124/jpet.104.067116 [Abstract] [Full Text] [PDF]  

Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley, and Jeff L. Staudinger

Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor
J Pharmacol Exp Ther 2004 310: 528-535. Published online April 1, 2004; 10.1124/jpet.103.064329 [Abstract] [Full Text] [PDF]  

Jun Lu, Nuala Helsby, Brian D. Palmer, Malcolm Tingle, Bruce C. Baguley, Philip Kestell, and Lai-Ming Ching

Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans
J Pharmacol Exp Ther 2004 310: 571-577. Published online April 9, 2004; 10.1124/jpet.104.067793 [Abstract] [Full Text] [PDF]  

Andrew W. E. Wright and Ronald G. Dickinson

Abolition of Valproate-Derived Choleresis in the Mrp2 Transporter-Deficient Rat
J Pharmacol Exp Ther 2004 310: 584-588. Published online April 9, 2004; 10.1124/jpet.103.064220 [Abstract] [Full Text] [PDF]  

Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto, and Yuichi Sugiyama

Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice
J Pharmacol Exp Ther 2004 310: 648-655. Published online May 6, 2004; 10.1124/jpet.104.065201 [Abstract] [Full Text] [PDF]  

Michael H. Court, Qin Hao, Soundararajan Krishnaswamy, Tanios Bekaii-Saab, Abdul Al-Rohaimi, Lisa L. von Moltke, and David J. Greenblatt

UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver
J Pharmacol Exp Ther 2004 310: 656-665. Published online March 25, 2004; 10.1124/jpet.104.067660 [Abstract] [Full Text] [PDF]  

Keith W. Ward and Leonard M. Azzarano

Preclinical Pharmacokinetic Properties of the P-Glycoprotein Inhibitor GF120918A (HCl salt of GF120918, 9,10-Dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the Mouse, Rat, Dog, and Monkey
J Pharmacol Exp Ther 2004 310: 703-709. Published online March 31, 2004; 10.1124/jpet.104.068288 [Abstract] [Full Text] [PDF]  

Ragini Vuppugalla and Reza Mehvar

Hepatic Disposition and Effects of Nitric Oxide Donors: Rapid and Concentration-Dependent Reduction in the Cytochrome P450-Mediated Drug Metabolism in Isolated Perfused Rat Livers
J Pharmacol Exp Ther 2004 310: 718-727. Published online March 29, 2004; 10.1124/jpet.104.065557 [Abstract] [Full Text] [PDF]  

Miki Shimada, Reiko Terazawa, Yoshiteru Kamiyama, Wataru Honma, Kiyoshi Nagata, and Yasushi Yamazoe

Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism
J Pharmacol Exp Ther 2004 310: 808-814. Published online April 15, 2004; 10.1124/jpet.104.065532 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Rouwayda El-Ayoubi, Ahmed Menaouar, Jolanta Gutkowska, and Suhayla Mukaddam-Daher

Imidazoline Receptors but Not ₂-Adrenoceptors Are Regulated in Spontaneously Hypertensive Rat Heart by Chronic Moxonidine Treatment
J Pharmacol Exp Ther 2004 310: 446-451. Published online April 9, 2004; 10.1124/jpet.104.067595 [Abstract] [Full Text] [PDF]  

Chun-Yang Xiao, Min Chen, Zsuzsanna Zsengellér, and Csaba Szabó

Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor
J Pharmacol Exp Ther 2004 310: 498-504. Published online March 30, 2004; 10.1124/jpet.104.066803 [Abstract] [Full Text] [PDF]  

Giuseppe Rossoni, Barbara Manfredi, Piero Del Soldato, and Ferruccio Berti

The Nitric Oxide-Releasing Naproxen Derivative Displays Cardioprotection in Perfused Rabbit Heart Submitted to Ischemia-Reperfusion
J Pharmacol Exp Ther 2004 310: 555-562. Published online April 13, 2004; 10.1124/jpet.104.067397 [Abstract] [Full Text] [PDF]  

Lin Wu, John C. Shryock, Yejia Song, Yuan Li, Charles Antzelevitch, and Luiz Belardinelli

Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome
J Pharmacol Exp Ther 2004 310: 599-605. Published online March 18, 2004; 10.1124/jpet.104.066100 [Abstract] [Full Text] [PDF]  

Jing Liu, Kenneth W. L. Kam, Jing-Jun Zhou, Wing-Yi Yan, Mai Chen, Song Wu, and Tak Ming Wong

Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or -Opioid Receptor Stimulation on Ca²⁺ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults
J Pharmacol Exp Ther 2004 310: 606-613. Published online March 29, 2004; 10.1124/jpet.104.067926 [Abstract] [Full Text] [PDF]  

Wei Xiong, Gregory R. Ferrier, and Susan E. Howlett

Diminished Inotropic Response to Amrinone in Ventricular Myocytes from Myopathic Hamsters Is Linked to Depression of High-Gain Ca²⁺-Induced Ca²⁺ Release
J Pharmacol Exp Ther 2004 310: 761-773. Published online April 2, 2004; 10.1124/jpet.103.064873 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould, and Douglas J. Pettibone

Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
J Pharmacol Exp Ther 2004 310: 488-497. Published online March 29, 2004; 10.1124/jpet.104.066886 [Abstract] [Full Text] [PDF]  

Jeremiah Gates, Jr., Shawn M. Ferguson, Randy D. Blakely, and Subbu Apparsundaram

Regulation of Choline Transporter Surface Expression and Phosphorylation by Protein Kinase C and Protein Phosphatase 1/2A
J Pharmacol Exp Ther 2004 310: 536-545. Published online April 2, 2004; 10.1124/jpet.104.066795 [Abstract] [Full Text] [PDF]  

Heather L. Butcher, Wendy A. Kennette, Olga Collins, Rudolfs K. Zalups, and James Koropatnick

Metallothionein Mediates the Level and Activity of Nuclear Factor KB in Murine Fibroblasts
J Pharmacol Exp Ther 2004 310: 589-598. Published online March 23, 2004; 10.1124/jpet.104.066126 [Abstract] [Full Text] [PDF]  

I. Lecoq, N. Marie, Ph. Jauzac, and S. Allouche

Different Regulation of Human -Opioid Receptors by SNC-80 [(+)-4-[(R)--((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Endogenous Enkephalins
J Pharmacol Exp Ther 2004 310: 666-677. Published online April 21, 2004; 10.1124/jpet.103.063958 [Abstract] [Full Text] [PDF]  

Martin Foltz, Antje Meyer, Stephan Theis, Hans-Ulrich Demuth, and Hannelore Daniel

A Rapid in Vitro Screening for Delivery of Peptide-Derived Peptidase Inhibitors as Potential Drug Candidates via Epithelial Peptide Transporters
J Pharmacol Exp Ther 2004 310: 695-702. Published online March 29, 2004; 10.1124/jpet.104.066480 [Abstract] [Full Text] [PDF]  

Mohamed A. Abdelmegeed, Sang K. Kim, Kimberley J. Woodcroft, and Raymond F. Novak

Acetoacetate Activation of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in Primary Cultured Rat Hepatocytes: Role of Oxidative Stress
J Pharmacol Exp Ther 2004 310: 728-736. Published online March 29, 2004; 10.1124/jpet.104.066522 [Abstract] [Full Text] [PDF]  

Norimitsu Morioka, Kei Kumagai, Katsuya Morita, Shigeo Kitayama, and Toshihiro Dohi

Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium (MPP⁺)-Induced Cell Death by Promoting the Intracellular Accumulation of MPP⁺ in PC12 Cells
J Pharmacol Exp Ther 2004 310: 800-807. Published online May 6, 2004; 10.1124/jpet.104.065300 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin, and Gianni Sava

Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
J Pharmacol Exp Ther 2004 310: 737-744. Published online April 9, 2004; 10.1124/jpet.104.066175 [Abstract] [Full Text] [PDF]  

Susan E. Bates, Wilma Y. Medina-Pérez, Glenda Kohlhagen, Smitha Antony, Tim Nadjem, Robert W. Robey, and Yves Pommier

ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
J Pharmacol Exp Ther 2004 310: 836-842. Published online April 9, 2004; 10.1124/jpet.103.063149 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki, and Isao Tanaka

Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
J Pharmacol Exp Ther 2004 310: 614-619. Published online March 23, 2004; 10.1124/jpet.103.064964 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Walter S. Kang, Frank J. Tamarkin, Marcia A. Wheeler, and Robert M. Weiss

Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
J Pharmacol Exp Ther 2004 310: 452-458. Published online April 13, 2004; 10.1124/jpet.104.066506 [Abstract] [Full Text] [PDF]  

Linda Yip, Henry Chi Hang Leung, and Yin Nam Kwok

Role of Adenosine A₁ Receptor in the Regulation of Gastrin Release
J Pharmacol Exp Ther 2004 310: 477-487. Published online March 24, 2004; 10.1124/jpet.104.066654 [Abstract] [Full Text] [PDF]  

Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery, and Bhagavatula Moorthy

Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
J Pharmacol Exp Ther 2004 310: 512-519. Published online May 3, 2004; 10.1124/jpet.103.059766 [Abstract] [Full Text] [PDF]  

Atsushi Masamune, Kazuhiro Kikuta, Noriaki Suzuki, Masahiro Satoh, Kennichi Satoh, and Tooru Shimosegawa

A c-Jun NH₂-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells
J Pharmacol Exp Ther 2004 310: 520-527. Published online March 31, 2004; 10.1124/jpet.104.067280 [Abstract] [Full Text] [PDF]  

Ryoko Ohno, Aya Yokota, Akiko Tanaka, and Koji Takeuchi

Induction of Small Intestinal Damage in Rats Following Combined Treatment with Cyclooxygenase-2 and Nitric-Oxide Synthase Inhibitors
J Pharmacol Exp Ther 2004 310: 821-827. Published online March 25, 2004; 10.1124/jpet.104.065961 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Timothy D. Warner, Ivana Vojnovic, Francesco Giuliano, Rosario Jiménez, David Bishop-Bailey, and Jane A. Mitchell

Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I₂: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues
J Pharmacol Exp Ther 2004 310: 642-647. Published online May 17, 2004; 10.1124/jpet.103.063875 [Abstract] [Full Text] [PDF]  

Waldiceu A. Verri, Jr, Ieda R. S. Schivo, Thiago M. Cunha, Foo Y. Liew, Sergio H. Ferreira, and Fernando Q. Cunha

Interleukin-18 Induces Mechanical Hypernociception in Rats via Endothelin Acting on ET_B Receptors in a Morphine-Sensitive Manner
J Pharmacol Exp Ther 2004 310: 710-717. Published online March 29, 2004; 10.1124/jpet.103.063990 [Abstract] [Full Text] [PDF]  

D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson, and J. A. Mancini

Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
J Pharmacol Exp Ther 2004 310: 752-760. Published online April 13, 2004; 10.1124/jpet.103.064691 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka, and Seitaro Mutoh

A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
J Pharmacol Exp Ther 2004 310: 425-436. Published online April 9, 2004; 10.1124/jpet.104.066944 [Abstract] [Full Text] [PDF]  

Thomas J. Abbruscato, Steve P. Lopez, Karen Roder, and Jennifer R. Paulson

Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter through Phosphorylation during in Vitro Stroke Conditions and Nicotine Exposure
J Pharmacol Exp Ther 2004 310: 459-468. Published online April 1, 2004; 10.1124/jpet.104.066274 [Abstract] [Full Text] [PDF]  

Amy Colquhoun, Gail M. Lawrance, Igor L. Shamovsky, Richard J. Riopelle, and Gregory M. Ross

Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75^NTR Interactions in the Presence of TrkA
J Pharmacol Exp Ther 2004 310: 505-511. Published online March 29, 2004; 10.1124/jpet.104.066225 [Abstract] [Full Text] [PDF]  

Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy, and Stephen Lin

Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R--Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
J Pharmacol Exp Ther 2004 310: 563-570. Published online April 9, 2004; 10.1124/jpet.104.066092 [Abstract] [Full Text] [PDF]  

Jordanna E. Bermack, Nasser Haddjeri, and Guy Debonnel

Effects of the Potential Antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone Monomethanesulfonate] a Combined and 5-HT_1A Ligand: Modulation of Neuronal Activity in the Dorsal Raphe Nucleus
J Pharmacol Exp Ther 2004 310: 578-583. Published online March 24, 2004; 10.1124/jpet.104.066472 [Abstract] [Full Text] [PDF]  

Jean De Vry, Dirk Denzer, Elke Reissmueller, Maud Eijckenboom, Markus Heil, Heinrich Meier, and Frank Mauler

3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB₁/CB₂ Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
J Pharmacol Exp Ther 2004 310: 620-632. Published online May 12, 2004; 10.1124/jpet.103.062836 [Abstract] [Full Text] [PDF]  

Patrick K. Harrison, Robert D. Sheridan, A. Chris Green, Iain R. Scott, and John E. H. Tattersall

A Guinea Pig Hippocampal Slice Model of Organophosphate-Induced Seizure Activity
J Pharmacol Exp Ther 2004 310: 678-686. Published online March 18, 2004; 10.1124/jpet.104.065433 [Abstract] [Full Text] [PDF]  

Christopher Bishop, Jennifer L. Tessmer, Thomas Ullrich, Kenner C. Rice, and Paul D. Walker

Serotonin 5-HT_2A Receptors Underlie Increased Motor Behaviors Induced in Dopamine-Depleted Rats by Intrastriatal 5-HT2A/2C Agonism
J Pharmacol Exp Ther 2004 310: 687-694. Published online March 25, 2004; 10.1124/jpet.104.066365 [Abstract] [Full Text] [PDF]  

V. Monnaert, S. Tilloy, H. Bricout, L. Fenart, R. Cecchelli, and E. Monflier

Behavior of -, -, and -Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier
J Pharmacol Exp Ther 2004 310: 745-751. Published online April 13, 2004; 10.1124/jpet.104.067512 [Abstract] [Full Text] [PDF]  

Daniella L. Muller and Ellen M. Unterwald

In Vivo Regulation of Extracellular Signal-Regulated Protein Kinase (ERK) and Protein Kinase B (Akt) Phosphorylation by Acute and Chronic Morphine
J Pharmacol Exp Ther 2004 310: 774-782. Published online March 31, 2004; 10.1124/jpet.104.066548 [Abstract] [Full Text] [PDF]  

Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle, and Kevin Broglé

DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
J Pharmacol Exp Ther 2004 310: 783-792. Published online March 30, 2004; 10.1124/jpet.103.063313 [Abstract] [Full Text] [PDF]  

Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker, and Kevin C. Broglé

DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
J Pharmacol Exp Ther 2004 310: 793-799. Published online March 30, 2004; 10.1124/jpet.103.063560 [Abstract] [Full Text] [PDF] Erratum  

Mark W. Lewis and David K. Pitts

Inorganic Lead Exposure in the Rat Activates Striatal cFOS Expression at Lower Blood Levels and Inhibits Amphetamine-Induced cFOS Expression at Higher Blood Levels
J Pharmacol Exp Ther 2004 310: 815-820. Published online April 26, 2004; 10.1124/jpet.103.063941 [Abstract] [Full Text] [PDF]  

Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper, and Anthony S. Basile

A Pulmonary Formulation of L-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
J Pharmacol Exp Ther 2004 310: 828-835. Published online March 23, 2004; 10.1124/jpet.103.064121 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Bridget Boland, Ching Yu Lin, Dexter Morin, Lisa Miller, Charles Plopper, and Alan Buckpitt

Site-Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques
J Pharmacol Exp Ther 2004 310: 546-554. Published online April 13, 2004; 10.1124/jpet.103.063669 [Abstract] [Full Text] [PDF]  

Andrew B. Maksymowych and Lance L. Simpson

Structural Features of the Botulinum Neurotoxin Molecule That Govern Binding and Transcytosis across Polarized Human Intestinal Epithelial Cells
J Pharmacol Exp Ther 2004 310: 633-641. Published online May 12, 2004; 10.1124/jpet.104.066845 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Effects of Alcohols and Anesthetics on Recombinant Voltage-Gated Na⁺ Channels"
J Pharmacol Exp Ther 2004 310: 843. [Full Text] [PDF]  

Correction to "Pharmacokinetics and Biodistribution of the Antitumor Immunoconjugate, Cantuzumab Mertansine (huC242-DM1), and Its Two Components in Mice"
J Pharmacol Exp Ther 2004 310: 844. [Full Text] [PDF]  

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