PERSPECTIVES IN PHARMACOLOGY:

Svein G. Dahl, Ingebrigt Sylte, and Aina Westrheim Ravna

Structures and Models of Transporter Proteins
J Pharmacol Exp Ther 2004 309: 853-860. Published online February 26, 2004; 10.1124/jpet.103.059972 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

John Desjardins, David L. Emerson, Dorothy B. Colagiovanni, Elizabeth Abbott, Eric N. Brown, and Daniel W. Drolet

Pharmacokinetics, Safety, and Efficacy of a Liposome Encapsulated Thymidylate Synthase Inhibitor, OSI-7904L [(S)-2-[5-[(1,2-Dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric Acid] in Mice
J Pharmacol Exp Ther 2004 309: 894-902. Published online February 24, 2004; 10.1124/jpet.103.064725 [Abstract] [Full Text] [PDF]  

María Carmen Iglesias-Osma, Maria José Garcia-Barrado, Virgile Visentin, Maria Francisca Pastor-Mansilla, Sandy Bour, Danielle Prévot, Philippe Valet, Julio Moratinos, and Christian Carpéné

Benzylamine Exhibits Insulin-Like Effects on Glucose Disposal, Glucose Transport, and Fat Cell Lipolysis in Rabbits and Diabetic Mice
J Pharmacol Exp Ther 2004 309: 1020-1028. Published online February 20, 2004; 10.1124/jpet.103.063636 [Abstract] [Full Text] [PDF]  

Mikako Kobayashi, Hiroshi Saitoh, Michiya Kobayashi, Koji Tadano, Yasushi Takahashi, and Tetsuo Hirano

Cyclosporin A, but Not Tacrolimus, Inhibits the Biliary Excretion of Mycophenolic Acid Glucuronide Possibly Mediated by Multidrug Resistance-Associated Protein 2 in Rats
J Pharmacol Exp Ther 2004 309: 1029-1035. Published online February 20, 2004; 10.1124/jpet.103.063073 [Abstract] [Full Text] [PDF]  

Alicia M. Segrave, Donald E. Mager, Susan A. Charman, Glenn A. Edwards, and Christopher J. H. Porter

Pharmacokinetics of Recombinant Human Leukemia Inhibitory Factor in Sheep
J Pharmacol Exp Ther 2004 309: 1085-1092. Published online February 10, 2004; 10.1124/jpet.103.063289 [Abstract] [Full Text] [PDF]  

Lefteris C. Zacharia, Claude A. Piché, Robert M. Fielding, Kathleen M. Holland, S. Dean Allison, Raghvendra K. Dubey, and Edwin K. Jackson

2-Hydroxyestradiol Is a Prodrug of 2-Methoxyestradiol
J Pharmacol Exp Ther 2004 309: 1093-1097. Published online February 10, 2004; 10.1124/jpet.103.062505 [Abstract] [Full Text] [PDF]  

Esa Meririnne, Satu Ellermaa, Aino Kankaanpää, Ali Bardy, and Timo Seppälä

Pharmacokinetics and Tissue Distribution of the Stereoisomers of 4-Methylaminorex in the Rat
J Pharmacol Exp Ther 2004 309: 1198-1205. Published online January 23, 2004; 10.1124/jpet.103.060053 [Abstract] [Full Text] [PDF]  

Shannon Dallas, Lyanne Schlichter, and Reina Bendayan

Multidrug Resistance Protein (MRP) 4- and MRP 5-Mediated Efflux of 9-(2-Phosphonylmethoxyethyl)adenine by Microglia
J Pharmacol Exp Ther 2004 309: 1221-1229. Published online February 4, 2004; 10.1124/jpet.103.063966 [Abstract] [Full Text] [PDF]  

Sumio Ohtsuki, Tazuru Kikkawa, Shinobu Mori, Satoko Hori, Hitomi Takanaga, Masaki Otagiri, and Tetsuya Terasaki

Mouse Reduced in Osteosclerosis Transporter Functions as an Organic Anion Transporter 3 and Is Localized at Abluminal Membrane of Blood-Brain Barrier
J Pharmacol Exp Ther 2004 309: 1273-1281. Published online February 4, 2004; 10.1124/jpet.103.063370 [Abstract] [Full Text] [PDF]  

T. Matsubara, H. J. Kim, M. Miyata, M. Shimada, K. Nagata, and Y. Yamazoe

Isolation and Characterization of a New Major Intestinal CYP3A Form, CYP3A62, in the Rat
J Pharmacol Exp Ther 2004 309: 1282-1290. Published online March 5, 2004; 10.1124/jpet.103.061671 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Stephen L. Boehm, II, Laura Peden, R. Adron Harris, and Yuri A. Blednov

Deletion of the fyn-Kinase Gene Alters Sensitivity to GABAergic Drugs: Dependence on 2/3 GABA_A Receptor Subunits
J Pharmacol Exp Ther 2004 309: 1154-1159. Published online February 5, 2004; 10.1124/jpet.103.064444 [Abstract] [Full Text] [PDF]  

D. E. McMillan, W. C. Hardwick, M. Li, M. G. Gunnell, F. I. Carroll, P. Abraham, and S. M. Owens

Effects of Murine-Derived Anti-Methamphetamine Monoclonal Antibodies on (+)-Methamphetamine Self-Administration in the Rat
J Pharmacol Exp Ther 2004 309: 1248-1255. Published online March 1, 2004; 10.1124/jpet.103.061762 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Thomas P. Beyer, Robert J. Schmidt, Patricia Foxworthy, Youyan Zhang, Jiannong Dai, William R. Bensch, Raymond F. Kauffman, Hong Gao, Timothy P. Ryan, Xian-Cheng Jiang, Sotirios K. Karathanasis, Patrick I. Eacho, and Guoqing Cao

Coadministration of a Liver X Receptor Agonist and a Peroxisome Proliferator Activator Receptor- Agonist in Mice: Effects of Nuclear Receptor Interplay on High-Density Lipoprotein and Triglyceride Metabolism in Vivo
J Pharmacol Exp Ther 2004 309: 861-868. Published online February 11, 2004; 10.1124/jpet.103.064535 [Abstract] [Full Text] [PDF]  

Koutaro Tsunemi, Shinji Takai, Masayoshi Nishimoto, Denan Jin, Masato Sakaguchi, Michiko Muramatsu, Atsushi Yuda, Shinjiro Sasaki, and Mizuo Miyazaki

A Specific Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppresses Development of Abdominal Aortic Aneurysm in Hamsters
J Pharmacol Exp Ther 2004 309: 879-883. Published online February 11, 2004; 10.1124/jpet.103.063974 [Abstract] [Full Text] [PDF]  

Kenji Kuwabara, Kohji Murakami, Makoto Todo, Tomiyoshi Aoki, Tetsuo Asaki, Masatoshi Murai, and Junichi Yano

A Novel Selective Peroxisome Proliferator-Activated Receptor Agonist, 2-Methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), Potently Decreases Plasma Triglyceride and Glucose Levels and Modifies Lipoprotein Profiles in KK-A^y Mice
J Pharmacol Exp Ther 2004 309: 970-977. Published online February 24, 2004; 10.1124/jpet.103.064659 [Abstract] [Full Text] [PDF]  

Yung-Ming Chen, Wen-Chih Chiang, Shuei-Liong Lin, Kwan-Dun Wu, Tun-Jun Tsai, and Bor-Shen Hsieh

Dual Regulation of Tumor Necrosis Factor--Induced CCL2/Monocyte Chemoattractant Protein-1 Expression in Vascular Smooth Muscle Cells by Nuclear Factor-B and Activator Protein-1: Modulation by Type III Phosphodiesterase Inhibition
J Pharmacol Exp Ther 2004 309: 978-986. Published online February 20, 2004; 10.1124/jpet.103.062620 [Abstract] [Full Text] [PDF]  

Erica A. Wehrwein, Carrie A. Northcott, Robert D. Loberg, and Stephanie W. Watts

Rho/Rho Kinase and Phosphoinositide 3-Kinase Are Parallel Pathways in the Development of Spontaneous Arterial Tone in Deoxycorticosterone Acetate-Salt Hypertension
J Pharmacol Exp Ther 2004 309: 1011-1019. Published online February 24, 2004; 10.1124/jpet.103.062265 [Abstract] [Full Text] [PDF]  

Glaucia E. Callera, Alvaro Yogi, Rita C. Tostes, Luciana V. Rossoni, and Lusiane M. Bendhack

Ca²⁺-Activated K⁺ Channels Underlying the Impaired Acetylcholine-Induced Vasodilation in 2K-1C Hypertensive Rats
J Pharmacol Exp Ther 2004 309: 1036-1042. Published online February 20, 2004; 10.1124/jpet.103.062810 [Abstract] [Full Text] [PDF]  

Jeffrey J. Olearczyk, Mary L. Ellsworth, Alan H. Stephenson, Andrew J. Lonigro, and Randy S. Sprague

Nitric Oxide Inhibits ATP Release from Erythrocytes
J Pharmacol Exp Ther 2004 309: 1079-1084. Published online February 6, 2004; 10.1124/jpet.103.064709 [Abstract] [Full Text] [PDF]  

John J. McGuire, Mahmoud Saifeddine, Chris R. Triggle, Kimberly Sun, and Morley D. Hollenberg

2-Furoyl-LIGRLO-amide: A Potent and Selective Proteinase-Activated Receptor 2 Agonist
J Pharmacol Exp Ther 2004 309: 1124-1131. Published online February 19, 2004; 10.1124/jpet.103.064584 [Abstract] [Full Text] [PDF]  

Patrick Osei-Owusu and Karie E. Scrogin

Buspirone Raises Blood Pressure through Activation of Sympathetic Nervous System and by Direct Activation of 1-Adrenergic Receptors after Severe Hemorrhage
J Pharmacol Exp Ther 2004 309: 1132-1140. Published online February 9, 2004; 10.1124/jpet.103.064626 [Abstract] [Full Text] [PDF]  

Anthony C. Sulpizio, Mark A. Pullen, Richard M. Edwards, and David P. Brooks

The Effect of Acute Angiotensin-Converting Enzyme and Neutral Endopeptidase 24.11 Inhibition on Plasma Extravasation in the Rat
J Pharmacol Exp Ther 2004 309: 1141-1147. Published online February 9, 2004; 10.1124/jpet.103.064105 [Abstract] [Full Text] [PDF]  

Romain Bos, Nathalie Mougenot, Odile Médiani, Paul M. Vanhoutte, and Philippe Lechat

Potassium Canrenoate, an Aldosterone Receptor Antagonist, Reduces Isoprenaline-Induced Cardiac Fibrosis in the Rat
J Pharmacol Exp Ther 2004 309: 1160-1166. Published online February 5, 2004; 10.1124/jpet.103.063388 [Abstract] [Full Text] [PDF]  

David A. Liem, Coen C. Gho, Ben C. Gho, Shahla Kazim, Olivier C. Manintveld, Pieter D. Verdouw, and Dirk J. Duncker

The Tyrosine Phosphatase Inhibitor Bis(Maltolato)Oxovanadium Attenuates Myocardial Reperfusion Injury by Opening ATP-Sensitive Potassium Channels
J Pharmacol Exp Ther 2004 309: 1256-1262. Published online March 1, 2004; 10.1124/jpet.103.062547 [Abstract] [Full Text] [PDF]  

Koji Nobe, Hikaru Suzuki, Yasushi Sakai, Hiromi Nobe, Richard J. Paul, and Kazutaka Momose

Glucose-Dependent Enhancement of Spontaneous Phasic Contraction Is Suppressed in Diabetic Mouse Portal Vein: Association with Diacylglycerol-Protein Kinase C Pathway
J Pharmacol Exp Ther 2004 309: 1263-1272. Published online February 26, 2004; 10.1124/jpet.103.062802 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Keiko Kashiwagi, Ikuko Tanaka, Maki Tamura, Hiromi Sugiyama, Tadashi Okawara, Masami Otsuka, Thomas N. Sabado, Keith Williams, and Kazuei Igarashi

Anthraquinone Polyamines: Novel Channel Blockers to Study N-Methyl-D-Aspartate Receptors
J Pharmacol Exp Ther 2004 309: 884-893. Published online February 5, 2004; 10.1124/jpet.103.062042 [Abstract] [Full Text] [PDF]  

Atsufumi Kawabata, Toru Kanke, Daiki Yonezawa, Tsuyoshi Ishiki, Masako Saka, Mototsugu Kabeya, Fumiko Sekiguchi, Satoko Kubo, Ryotaro Kuroda, Masahiro Iwaki, Kousaku Katsura, and Robin Plevin

Potent and Metabolically Stable Agonists for Protease-Activated Receptor-2: Evaluation of Activity in Multiple Assay Systems in Vitro and in Vivo
J Pharmacol Exp Ther 2004 309: 1098-1107. Published online February 19, 2004; 10.1124/jpet.103.061010 [Abstract] [Full Text] [PDF]  

Nicol Strakova, Jiri Ehrmann, Petr Dzubak, Jan Bouchal, and Zdenek Kolar

The Synthetic Ligand of Peroxisome Proliferator-Activated Receptor- Ciglitazone Affects Human Glioblastoma Cell Lines
J Pharmacol Exp Ther 2004 309: 1239-1247. Published online February 26, 2004; 10.1124/jpet.103.063438 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Aiping Bai, G. Patrick Meier, Yong Wang, Chiara Luberto, Yusuf A. Hannun, and Daohong Zhou

Prodrug Modification Increases Potassium Tricyclo[5.2.1.0^2,6]-decan-8-yl Dithiocarbonate (D609) Chemical Stability and Cytotoxicity against U937 Leukemia Cells
J Pharmacol Exp Ther 2004 309: 1051-1059. Published online February 11, 2004; 10.1124/jpet.103.064600 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Kaname Uno, Yoshihito Iuchi, Junichi Fujii, Hideaki Sugata, Katsunori Iijima, Katsuaki Kato, Tooru Shimosegawa, and Tetsuhiko Yoshimura

In Vivo Study on Cross Talk between Inducible Nitric-Oxide Synthase and Cyclooxygenase in Rat Gastric Mucosa: Effect of Cyclooxygenase Activity on Nitric Oxide Production
J Pharmacol Exp Ther 2004 309: 995-1002. Published online February 26, 2004; 10.1124/jpet.103.061283 [Abstract] [Full Text] [PDF]  

Tim Schneider, Charlotte Fetscher, Susanne Krege, and Martin C. Michel

Signal Transduction Underlying Carbachol-Induced Contraction of Human Urinary Bladder
J Pharmacol Exp Ther 2004 309: 1148-1153. Published online February 9, 2004; 10.1124/jpet.103.063735 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Marcello Trevisani, David Gazzieri, Francesca Benvenuti, Barbara Campi, Q. Thai Dinh, David A. Groneberg, Michela Rigoni, Xavier Emonds-Alt, Christophe Creminon, Axel Fischer, Pierangelo Geppetti, and Selena Harrison

Ethanol Causes Inflammation in the Airways by a Neurogenic and TRPV1-Dependent Mechanism
J Pharmacol Exp Ther 2004 309: 1167-1173. Published online February 4, 2004; 10.1124/jpet.103.064162 [Abstract] [Full Text] [PDF]  

Stefano Fiorucci, Eleonora Distrutti, Andrea Mencarelli, Giovanni Rizzo, Anna Rita Di Lorenzo, Monia Baldoni, Piero del Soldato, Antonio Morelli, and John L. Wallace

Cooperation between Aspirin-Triggered Lipoxin and Nitric Oxide (NO) Mediates Antiadhesive Properties of 2-(Acetyloxy)benzoic Acid 3-(Nitrooxymethyl)phenyl Ester (NCX-4016) (NO-Aspirin) on Neutrophil-Endothelial Cell Adherence
J Pharmacol Exp Ther 2004 309: 1174-1182. Published online February 4, 2004; 10.1124/jpet.103.063651 [Abstract] [Full Text] [PDF]  

Shinichiro Kubo, Hideo Kohka Takahashi, Masao Takei, Hiromi Iwagaki, Tadashi Yoshino, Noriaki Tanaka, Shuji Mori, and Masahiro Nishibori

E-Prostanoid (EP)2/EP4 Receptor-Dependent Maturation of Human Monocyte-Derived Dendritic Cells and Induction of Helper T2 Polarization
J Pharmacol Exp Ther 2004 309: 1213-1220. Published online February 10, 2004; 10.1124/jpet.103.062646 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Zhi-Qiang Wang, Frank Porreca, Salvatore Cuzzocrea, Karen Galen, Richard Lightfoot, Emanuela Masini, Carolina Muscoli, Vincenzo Mollace, Michael Ndengele, Harry Ischiropoulos, and Daniela Salvemini

A Newly Identified Role for Superoxide in Inflammatory Pain
J Pharmacol Exp Ther 2004 309: 869-878. Published online February 26, 2004; 10.1124/jpet.103.064154 [Abstract] [Full Text] [PDF]  

Mark J. Millan, Didier Cussac, Alain Gobert, Françoise Lejeune, Jean-Michel Rivet, Clotilde Mannoury La Cour, Adrian Newman-Tancredi, and Jean-Louis Peglion

S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: I. Cellular, Electrophysiological, and Neurochemical Profile in Comparison with Ropinirole
J Pharmacol Exp Ther 2004 309: 903-920. Published online February 20, 2004; 10.1124/jpet.103.062398 [Abstract] [Full Text] [PDF]  

Mark J. Millan, Benjamin Di Cara, Michael Hill, Michael Jackson, Jeffrey N. Joyce, Jonathan Brotchie, Steve McGuire, Alan Crossman, Lance Smith, Peter Jenner, Alain Gobert, Jean-Louis Peglion, and Mauricette Brocco

S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: II. Actions in Rodent, Primate, and Cellular Models of Antiparkinsonian Activity in Comparison to Ropinirole
J Pharmacol Exp Ther 2004 309: 921-935. Published online February 20, 2004; 10.1124/jpet.103.062414 [Abstract] [Full Text] [PDF]  

Mark J. Millan, Mauricette Brocco, Mariusz Papp, Florence Serres, Christophe Drieu La Rochelle, Trevor Sharp, Jean-Louis Peglion, and Anne Dekeyne

S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole
J Pharmacol Exp Ther 2004 309: 936-950. Published online February 20, 2004; 10.1124/jpet.103.062463 [Abstract] [Full Text] [PDF]  

Su-Jane Wang and Talvinder S. Sihra

Noncompetitive Metabotropic Glutamate₅ Receptor Antagonist (E)-2-Methyl-6-styryl-pyridine (SIB1893) Depresses Glutamate Release through Inhibition of Voltage-Dependent Ca²⁺ Entry in Rat Cerebrocortical Nerve Terminals (Synaptosomes)
J Pharmacol Exp Ther 2004 309: 951-958. Published online February 24, 2004; 10.1124/jpet.103.064881 [Abstract] [Full Text] [PDF]  

Kimberly P. Lindsey, Kristin M. Wilcox, John R. Votaw, Mark M. Goodman, Christophe Plisson, F. Ivy Carroll, Kenner C. Rice, and Leonard L. Howell

Effects of Dopamine Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys: Relationship to Transporter Occupancy Determined by Positron Emission Tomography Neuroimaging
J Pharmacol Exp Ther 2004 309: 959-969. Published online February 24, 2004; 10.1124/jpet.103.060293 [Abstract] [Full Text] [PDF]  

Munehiro Shiraishi and R. Adron Harris

Effects of Alcohols and Anesthetics on Recombinant Voltage-Gated Na⁺ Channels
J Pharmacol Exp Ther 2004 309: 987-994. Published online February 20, 2004; 10.1124/jpet.103.064063 [Abstract] [Full Text] [PDF]  

Jeppe K. Christensen, Thomas Varming, Philip K. Ahring, Tino D. Jørgensen, and Elsebet Ø. Nielsen

In Vitro Characterization of 5-Carboxyl-2,4-di-benzamidobenzoic Acid (NS3763), a Noncompetitive Antagonist of GLU_K5 Receptors
J Pharmacol Exp Ther 2004 309: 1003-1010. Published online February 25, 2004; 10.1124/jpet.103.062794 [Abstract] [Full Text] [PDF]  

K. J. Damjanoska, B. A. Heidenreich, G. H. Kindel, D. N. D'Souza, Y. Zhang, F. Garcia, G. Battaglia, W. A. Wolf, L. D. Van de Kar, and N. A. Muma

Agonist-Induced Serotonin 2A Receptor Desensitization in the Rat Frontal Cortex and Hypothalamus
J Pharmacol Exp Ther 2004 309: 1043-1050. Published online February 19, 2004; 10.1124/jpet.103.062067 [Abstract] [Full Text] [PDF]  

Janna M. Silakova, James A. Hewett, and Sandra J. Hewett

Naproxen Reduces Excitotoxic Neurodegeneration in Vivo with an Extended Therapeutic Window
J Pharmacol Exp Ther 2004 309: 1060-1066. Published online February 9, 2004; 10.1124/jpet.103.063867 [Abstract] [Full Text] [PDF]  

Akinori Iwashita, Syunji Yamazaki, Kayoko Mihara, Kouji Hattori, Hirofumi Yamamoto, Junya Ishida, Nobuya Matsuoka, and Seitaro Mutoh

Neuroprotective Effects of a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-Chlorophenyl)-1-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in Vitro Model of Cell Death and in Mouse 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Parkinson's Disease
J Pharmacol Exp Ther 2004 309: 1067-1078. Published online February 25, 2004; 10.1124/jpet.103.064642 [Abstract] [Full Text] [PDF]  

Brandon C. Drafts and Janet L. Fisher

Structural Determinants of the Pharmacological Properties of the GABA_A Receptor 6 Subunit
J Pharmacol Exp Ther 2004 309: 1108-1115. Published online February 4, 2004; 10.1124/jpet.103.064360 [Abstract] [Full Text] [PDF]  

Burt M. Sharp, M. Yatsula, and Yitong Fu

Effects of Galantamine, a Nicotinic Allosteric Potentiating Ligand, on Nicotine-Induced Catecholamine Release in Hippocampus and Nucleus Accumbens of Rats
J Pharmacol Exp Ther 2004 309: 1116-1123. Published online February 9, 2004; 10.1124/jpet.103.063586 [Abstract] [Full Text] [PDF]  

Michael F. Wilkemeyer, Shao-yu Chen, Carrie E. Menkari, Kathleen K. Sulik, and Michael E. Charness

Ethanol Antagonist Peptides: Structural Specificity without Stereospecificity
J Pharmacol Exp Ther 2004 309: 1183-1189. Published online February 4, 2004; 10.1124/jpet.103.063818 [Abstract] [Full Text] [PDF]  

Xinyu D. Li and Jerry J. Buccafusco

Role of 7 Nicotinic Acetylcholine Receptors in the Pressor Response to Intracerebroventricular Injection of Choline: Blockade by Amyloid Peptide A1-42
J Pharmacol Exp Ther 2004 309: 1206-1212. Published online February 19, 2004; 10.1124/jpet.103.063321 [Abstract] [Full Text] [PDF]  

R. Suzuki, M. Edwards, and A. H. Dickenson

ReN-1869 [(R)-1-(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine Carboxylic Acid], a Novel Histamine H1 Receptor Antagonist, Produces Potent and Selective Antinociceptive Effects on Dorsal Horn Neurons after Inflammation and Neuropathy
J Pharmacol Exp Ther 2004 309: 1230-1238. Published online February 26, 2004; 10.1124/jpet.103.063511 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Douglas E. Brenneman, Catherine Y. Spong, Janet M. Hauser, Daniel Abebe, Albert Pinhasov, Tania Golian, and Illana Gozes

Protective Peptides That Are Orally Active and Mechanistically Nonchiral
J Pharmacol Exp Ther 2004 309: 1190-1197. Published online March 8, 2004; 10.1124/jpet.103.063891 [Abstract] [Full Text] [PDF]  

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