PERSPECTIVES IN PHARMACOLOGY:

Robert B. Moreland, Jorge D. Brioni, and James P. Sullivan

Emerging Pharmacologic Approaches for the Treatment of Lower Urinary Tract Disorders
J Pharmacol Exp Ther 2004 308: 797-804. Published online January 12, 2004; 10.1124/jpet.102.034991 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Kiran C. Patki, Lisa L. von Moltke, Jerold S. Harmatz, Leah M. Hesse, Michael H. Court, and David J. Greenblatt

Effect of Age on in Vitro Triazolam Biotransformation in Male Human Liver Microsomes
J Pharmacol Exp Ther 2004 308: 874-879. Published online November 21, 2003; 10.1124/jpet.103.059311 [Abstract] [Full Text] [PDF]  

Stéphane J. Mouly, Mary F. Paine, and Paul B. Watkins

Contributions of CYP3A4, P-glycoprotein, and Serum Protein Binding to the Intestinal First-Pass Extraction of Saquinavir
J Pharmacol Exp Ther 2004 308: 941-948. Published online January 8, 2004; 10.1124/jpet.103.056390 [Abstract] [Full Text] [PDF]  

Sevasti B. Koukouritaki, Jason R. Manro, Sandra A. Marsh, Jeffrey C. Stevens, Allan E. Rettie, D. Gail McCarver, and Ronald N. Hines

Developmental Expression of Human Hepatic CYP2C9 and CYP2C19
J Pharmacol Exp Ther 2004 308: 965-974. Published online November 21, 2003; 10.1124/jpet.103.060137 [Abstract] [Full Text] [PDF]  

Cedric Moro, Jean Galitzky, Coralie Sengenes, François Crampes, Max Lafontan, and Michel Berlan

Functional and Pharmacological Characterization of the Natriuretic Peptide-Dependent Lipolytic Pathway in Human Fat Cells
J Pharmacol Exp Ther 2004 308: 984-992. Published online November 21, 2003; 10.1124/jpet.103.060913 [Abstract] [Full Text] [PDF]  

Yvonne Y. Lau, Chi-Yuan Wu, Hideaki Okochi, and Leslie Z. Benet

Ex Situ Inhibition of Hepatic Uptake and Efflux Significantly Changes Metabolism: Hepatic Enzyme-Transporter Interplay
J Pharmacol Exp Ther 2004 308: 1040-1045. Published online November 21, 2003; 10.1124/jpet.103.061770 [Abstract] [Full Text] [PDF]  

Hongsheng Xie, Charlene Audette, Mary Hoffee, John M. Lambert, and Walter A. Blättler

Pharmacokinetics and Biodistribution of the Antitumor Immunoconjugate, Cantuzumab Mertansine (huC242-DM1), and Its Two Components in Mice
J Pharmacol Exp Ther 2004 308: 1073-1082. Published online November 21, 2003; 10.1124/jpet.103.060533 [Abstract] [Full Text] [PDF] Correction  

Alexander Treiber, Ralph Schneiter, Stephane Delahaye, and Martine Clozel

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat
J Pharmacol Exp Ther 2004 308: 1121-1129. Published online November 14, 2003; 10.1124/jpet.103.061614 [Abstract] [Full Text] [PDF]  

Takahiro Hatanaka, Masayuki Haramura, You-Jun Fei, Seiji Miyauchi, Christy C. Bridges, Preethi S. Ganapathy, Sylvia B. Smith, Vadivel Ganapathy, and Malliga E. Ganapathy

Transport of Amino Acid-Based Prodrugs by the Na⁺- and Cl^--Coupled Amino Acid Transporter ATB^0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery
J Pharmacol Exp Ther 2004 308: 1138-1147. Published online November 14, 2003; 10.1124/jpet.103.057109 [Abstract] [Full Text] [PDF]  

Ruolun Qiu, Thomas F. Kalhorn, and John T. Slattery

ABCC2-Mediated Biliary Transport of 4-Glutathionylcyclophosphamide and Its Contribution to Elimination of 4-Hydroxycyclophosphamide in Rat
J Pharmacol Exp Ther 2004 308: 1204-1212. Published online November 14, 2003; 10.1124/jpet.103.059105 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Wouter Koek, Lauren R. Flores, Lawrence P. Carter, R. J. Lamb, Weibin Chen, Huifang Wu, Andrew Coop, and Charles P. France

Discriminative Stimulus Effects of -Hydroxybutyrate in Pigeons: Role of Diazepam-Sensitive and -Insensitive GABA_A and GABA_B Receptors
J Pharmacol Exp Ther 2004 308: 904-911. Published online January 12, 2004; 10.1124/jpet.103.056093 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

John A. Auchampach, Xiaowei Jin, Jeannine Moore, Tina C. Wan, Laura M. Kreckler, Zhi-Dong Ge, Jayashree Narayanan, Eric Whalley, William Kiesman, Barry Ticho, Glenn Smits, and Garrett J. Gross

Comparison of Three Different A₁ Adenosine Receptor Antagonists on Infarct Size and Multiple Cycle Ischemic Preconditioning in Anesthetized Dogs
J Pharmacol Exp Ther 2004 308: 846-856. Published online November 21, 2003; 10.1124/jpet.103.057943 [Abstract] [Full Text] [PDF]  

Fengyun Xu, John R. Falck, Paul R. Ortiz de Montellano, and Deanna L. Kroetz

Catalytic Activity and Isoform-Specific Inhibition of Rat Cytochrome P450 4F Enzymes
J Pharmacol Exp Ther 2004 308: 887-895. Published online November 21, 2003; 10.1124/jpet.103.059626 [Abstract] [Full Text] [PDF]  

Jiesheng Kang, Xiao-Liang Chen, Hongge Wang, Junzhi Ji, William Reynolds, Sungtaek Lim, James Hendrix, and David Rampe

Cardiac Ion Channel Effects of Tolterodine
J Pharmacol Exp Ther 2004 308: 935-940. Published online January 7, 2004; 10.1124/jpet.103.062182 [Abstract] [Full Text] [PDF]  

Meike Schwarz, Yasuhiro Katagiri, Masaharu Kotani, Nicole Bassler, Christoph Loeffler, Christoph Bode, and Karlheinz Peter

Reversibility versus Persistence of GPIIb/IIIa Blocker-Induced Conformational Change of GPIIb/IIIa (_IIb3, CD41/CD61)
J Pharmacol Exp Ther 2004 308: 1002-1011. Published online November 14, 2003; 10.1124/jpet.103.058883 [Abstract] [Full Text] [PDF]  

Laine J. Murphey, Wendy K. Eccles, Gordon H. Williams, and Nancy J. Brown

Loss of Sodium Modulation of Plasma Kinins in Human Hypertension
J Pharmacol Exp Ther 2004 308: 1046-1052. Published online January 8, 2004; 10.1124/jpet.103.059337 [Abstract] [Full Text] [PDF]  

Jeanette Woolard, Terence Bennett, William R. Dunn, David J. Heal, Susan Aspley, and Sheila M. Gardiner

Acute Cardiovascular Effects of Sibutramine in Conscious Rats
J Pharmacol Exp Ther 2004 308: 1102-1110. Published online November 21, 2003; 10.1124/jpet.103.061259 [Abstract] [Full Text] [PDF]  

Philippe de Medina, Bruno L. Payré, José Bernad, Isabelle Bosser, Bernard Pipy, Sandrine Silvente-Poirot, Gilles Favre, Jean-Charles Faye, and Marc Poirot

Tamoxifen Is a Potent Inhibitor of Cholesterol Esterification and Prevents the Formation of Foam Cells
J Pharmacol Exp Ther 2004 308: 1165-1173. Published online November 14, 2003; 10.1124/jpet.103.060426 [Abstract] [Full Text] [PDF]  

Manabu Nishio, Stuart W. Ruch, James E. Kelly, Gary L. Aistrup, Katherine Sheehan, and J. Andrew Wasserstrom

Ouabain Increases Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes
J Pharmacol Exp Ther 2004 308: 1181-1190. Published online November 21, 2003; 10.1124/jpet.103.060004 [Abstract] [Full Text] [PDF]  

Chia-Hui Lin, Wan-Chen Lo, Michael Hsiao, Che-Se Tung, and Ching-Jiunn Tseng

Interactions of Carbon Monoxide and Metabotropic Glutamate Receptor Groups in the Nucleus Tractus Solitarii of Rats
J Pharmacol Exp Ther 2004 308: 1213-1218. Published online November 14, 2003; 10.1124/jpet.103.060186 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Young-Mi Ham, Kyoung-Jin Choi, Sun-Yong Song, Ying-Hua Jin, Moon-Woo Chun, and Seung-Ki Lee

Xylocydine, a Novel Inhibitor of Cyclin-Dependent Kinases, Prevents the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptotic Cell Death of SK-HEP-1 Cells
J Pharmacol Exp Ther 2004 308: 814-819. Published online November 14, 2003; 10.1124/jpet.103.059568 [Abstract] [Full Text] [PDF]  

Alfred Lanzafame and Arthur Christopoulos

Investigation of the Interaction of a Putative Allosteric Modulator, N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) Methanamine Hydrobromide (SCH-202676), with M₁ Muscarinic Acetylcholine Receptors
J Pharmacol Exp Ther 2004 308: 830-837. Published online November 14, 2003; 10.1124/jpet.103.060590 [Abstract] [Full Text] [PDF]  

Paola Massi, Angelo Vaccani, Stefania Ceruti, Arianna Colombo, Maria P. Abbracchio, and Daniela Parolaro

Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
J Pharmacol Exp Ther 2004 308: 838-845. Published online November 14, 2003; 10.1124/jpet.103.061002 [Abstract] [Full Text] [PDF]  

Diana L. Donnelly-Roberts, Marian T. Namovic, Connie R. Faltynek, and Michael F. Jarvis

Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X₇ Receptor (P2X₇R)-Induced Pore Formation in Human THP-1 Cells
J Pharmacol Exp Ther 2004 308: 1053-1061. Published online November 21, 2003; 10.1124/jpet.103.059600 [Abstract] [Full Text] [PDF]  

Vimesh Avlani, Lauren T. May, Patrick M. Sexton, and Arthur Christopoulos

Application of a Kinetic Model to the Apparently Complex Behavior of Negative and Positive Allosteric Modulators of Muscarinic Acetylcholine Receptors
J Pharmacol Exp Ther 2004 308: 1062-1072. Published online January 7, 2004; 10.1124/jpet.103.059840 [Abstract] [Full Text] [PDF]  

James R. Hammond and Richard G. E. Archer

Interaction of the Novel Adenosine Uptake Inhibitor 3-[1-(6,7-Diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazolinedione Hydrochloride (KF24345) with the es and ei Subtypes of Equilibrative Nucleoside Transporters
J Pharmacol Exp Ther 2004 308: 1083-1093. Published online November 21, 2003; 10.1124/jpet.103.060434 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Thomas W. Davis, Ben S. Zweifel, Janet M. O'Neal, Deborah M. Heuvelman, Ann L. Abegg, Todd O. Hendrich, and Jaime L. Masferrer

Inhibition of Cyclooxygenase-2 by Celecoxib Reverses Tumor-Induced Wasting
J Pharmacol Exp Ther 2004 308: 929-934. Published online January 7, 2004; 10.1124/jpet.103.063099 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Brett Grover, Donna Buckley, Arthur R. Buckley, and William Cacini

Reduced Expression of Organic Cation Transporters rOCT1 and rOCT2 in Experimental Diabetes
J Pharmacol Exp Ther 2004 308: 949-956. Published online January 8, 2004; 10.1124/jpet.103.058388 [Abstract] [Full Text] [PDF]  

Habib Hasannejad, Michio Takeda, Kentarou Taki, Ho Jung Shin, Ellappan Babu, Promsuk Jutabha, Suparat Khamdang, Mahmoud Aleboyeh, Maristela Lika Onozato, Akihiro Tojo, Atsushi Enomoto, Naohiko Anzai, Shinichi Narikawa, Xiu-Lin Huang, Toshimitsu Niwa, and Hitoshi Endou

Interactions of Human Organic Anion Transporters with Diuretics
J Pharmacol Exp Ther 2004 308: 1021-1029. Published online November 10, 2003; 10.1124/jpet.103.059139 [Abstract] [Full Text] [PDF]  

Fangxia Li, Márcio De Godoy, and Satish Rattan

Role of Adenylate and Guanylate Cyclases in ₁-, ₂-, and ₃-Adrenoceptor-Mediated Relaxation of Internal Anal Sphincter Smooth Muscle
J Pharmacol Exp Ther 2004 308: 1111-1120. Published online January 7, 2004; 10.1124/jpet.103.060145 [Abstract] [Full Text] [PDF]  

Renate Bang, Markus Biburger, Winfried L. Neuhuber, and Gisa Tiegs

Neurokinin-1 Receptor Antagonists Protect Mice from CD95- and Tumor Necrosis Factor--Mediated Apoptotic Liver Damage
J Pharmacol Exp Ther 2004 308: 1174-1180. Published online November 14, 2003; 10.1124/jpet.103.059329 [Abstract] [Full Text] [PDF]  

Ali Canbay, Ariel Feldstein, Edwina Baskin-Bey, Steven F. Bronk, and Gregory J. Gores

The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse
J Pharmacol Exp Ther 2004 308: 1191-1196. Published online November 14, 2003; 10.1124/jpet.103.060129 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Charles Kunsch, Jayraz Luchoomun, Janice Y. Grey, Lynda K. Olliff, Leigh B. Saint, Richard F. Arrendale, Martin A. Wasserman, Uday Saxena, and Russell M. Medford

Selective Inhibition of Endothelial and Monocyte Redox-Sensitive Genes by AGI-1067: A Novel Antioxidant and Anti-Inflammatory Agent
J Pharmacol Exp Ther 2004 308: 820-829. Published online November 14, 2003; 10.1124/jpet.103.059733 [Abstract] [Full Text] [PDF]  

Hideki Shimizu, Michio Miyoshi, Kenji Matsumoto, Osamu Goto, Toshiaki Imoto, and Tatsuo Watanabe

The Effect of Central Injection of Angiotensin-Converting Enzyme Inhibitor and the Angiotensin Type 1 Receptor Antagonist on the Induction by Lipopolysaccharide of Fever and Brain Interleukin-1 Response in Rats
J Pharmacol Exp Ther 2004 308: 865-873. Published online November 14, 2003; 10.1124/jpet.103.060392 [Abstract] [Full Text] [PDF]  

Nieves Márquez, Rocío Sancho, Antonio Macho, Marco A. Calzado, Bernd L. Fiebich, and Eduardo Muñoz

Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-B Transcription Factors
J Pharmacol Exp Ther 2004 308: 993-1001. Published online November 14, 2003; 10.1124/jpet.103.060673 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Michael E. Hildebrand, John E. McRory, Terrance P. Snutch, and Anthony Stea

Mammalian Voltage-Gated Calcium Channels Are Potently Blocked by the Pyrethroid Insecticide Allethrin
J Pharmacol Exp Ther 2004 308: 805-813. Published online November 21, 2003; 10.1124/jpet.103.058792 [Abstract] [Full Text] [PDF]  

A. Jarrahian, V. J. Watts, and E. L. Barker

D₂ Dopamine Receptors Modulate G-Subunit Coupling of the CB₁ Cannabinoid Receptor
J Pharmacol Exp Ther 2004 308: 880-886. Published online November 21, 2003; 10.1124/jpet.103.057620 [Abstract] [Full Text] [PDF]  

Jeong Hyun Lee, Ki Young Kim, Yong-Kyu Lee, So Youn Park, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim, and Ki Whan Hong

Cilostazol Prevents Focal Cerebral Ischemic Injury by Enhancing Casein Kinase 2 Phosphorylation and Suppression of Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation in Rats
J Pharmacol Exp Ther 2004 308: 896-903. Published online November 21, 2003; 10.1124/jpet.103.061853 [Abstract] [Full Text] [PDF]  

C. Anthonypillai, R. N. Sanderson, J. E. Gibbs, and S. A. Thomas

The Distribution of the HIV Protease Inhibitor, Ritonavir, to the Brain, Cerebrospinal Fluid, and Choroid Plexuses of the Guinea Pig
J Pharmacol Exp Ther 2004 308: 912-920. Published online November 21, 2003; 10.1124/jpet.103.060210 [Abstract] [Full Text] [PDF]  

J. M. Witkin, D. Dijkstra, B. Levant, H. C. Akunne, A. Zapata, S. Peters, H. E. Shannon, and M. Gasior

Protection against Cocaine Toxicity in Mice by the Dopamine D₃/D₂ Agonist R-(+)-trans-3,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD 128,907]
J Pharmacol Exp Ther 2004 308: 957-964. Published online January 7, 2004; 10.1124/jpet.103.059980 [Abstract] [Full Text] [PDF]  

Tongguang Wang, Bin Liu, Wei Zhang, Belinda Wilson, and Jau-Shyong Hong

Andrographolide Reduces Inflammation-Mediated Dopaminergic Neurodegeneration in Mesencephalic Neuron-Glia Cultures by Inhibiting Microglial Activation
J Pharmacol Exp Ther 2004 308: 975-983. Published online January 8, 2004; 10.1124/jpet.103.059683 [Abstract] [Full Text] [PDF]  

Klaas P. Zuideveld, Piet H. Van der Graaf, Donald Newgreen, Richard Thurlow, Nicola Petty, Paul Jordan, Lambertus A. Peletier, and Meindert Danhof

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of 5-HT_1A Receptor Agonists: Estimation of in Vivo Affinity and Intrinsic Efficacy on Body Temperature in Rats
J Pharmacol Exp Ther 2004 308: 1012-1020. Published online January 8, 2004; 10.1124/jpet.103.059030 [Abstract] [Full Text] [PDF]  

Donna M. Platt, James K. Rowlett, Sari Izenwasser, and Roger D. Spealman

Opioid Partial Agonist Effects of 3-O-Methylnaltrexone in Rhesus Monkeys
J Pharmacol Exp Ther 2004 308: 1030-1039. Published online November 21, 2003; 10.1124/jpet.103.060962 [Abstract] [Full Text] [PDF]  

Akira Moriguchi, Toshiaki Aoki, Kayoko Mihara, Nobuteru Tojo, Nobuya Matsuoka, and Seitaro Mutoh

Antithrombotic Effects of FK419, a Novel Nonpeptide Platelet GPIIb/IIIa Antagonist, in a Guinea Pig Photochemically Induced Middle Cerebral Artery Thrombosis Model: Comparison with Ozagrel and Argatroban
J Pharmacol Exp Ther 2004 308: 1094-1101. Published online November 21, 2003; 10.1124/jpet.103.058073 [Abstract] [Full Text] [PDF]  

Pascal Bonaventure, Diane Nepomuceno, Curt Mazur, Brian Lord, Dale A. Rudolph, Jill A. Jablonowski, Nicholas I. Carruthers, and Timothy W. Lovenberg

Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a Small Molecule Antagonist of the Neuropeptide Y Y₂ Receptor
J Pharmacol Exp Ther 2004 308: 1130-1137. Published online November 14, 2003; 10.1124/jpet.103.060459 [Abstract] [Full Text] [PDF]  

R. Gómez-Villafuertes, J. Pintor, J. Gualix, and M. T. Miras-Portugal

GABA Modulates Presynaptic Signalling Mediated by Dinucleotides on Rat Synaptic Terminals
J Pharmacol Exp Ther 2004 308: 1148-1157. Published online January 7, 2004; 10.1124/jpet.103.061564 [Abstract] [Full Text] [PDF]  

Md Harunor Rashid, Makoto Inoue, Misaki Matsumoto, and Hiroshi Ueda

Switching of Bradykinin-Mediated Nociception Following Partial Sciatic Nerve Injury in Mice
J Pharmacol Exp Ther 2004 308: 1158-1164. Published online November 21, 2003; 10.1124/jpet.103.060335 [Abstract] [Full Text] [PDF]  

Charles Chavkin, Sumit Sud, Wenzhen Jin, Jeremy Stewart, Jordan K. Zjawiony, Daniel J. Siebert, Beth Ann Toth, Sandra J. Hufeisen, and Bryan L. Roth

Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious -Opioid Receptor Agonist: Structural and Functional Considerations
J Pharmacol Exp Ther 2004 308: 1197-1203. Published online January 8, 2004; 10.1124/jpet.103.059394 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Lance L. Simpson, Andrew B. Maksymowych, Jong-Beak Park, and Roop S. Bora

The Role of the Interchain Disulfide Bond in Governing the Pharmacological Actions of Botulinum Toxin
J Pharmacol Exp Ther 2004 308: 857-864. Published online November 14, 2003; 10.1124/jpet.103.058149 [Abstract] [Full Text] [PDF]  

Brian S. Cummings, Jane McHowat, and Rick G. Schnellmann

Role of an Endoplasmic Reticulum Ca²⁺-Independent Phospholipase A₂ in Cisplatin-Induced Renal Cell Apoptosis
J Pharmacol Exp Ther 2004 308: 921-928. Published online November 21, 2003; 10.1124/jpet.103.060541 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms: Catalytic Activities of the Naturally Occurring Variant Enzymes"
J Pharmacol Exp Ther 2004 308: 1219. [Full Text] [PDF]  

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