PERSPECTIVES IN PHARMACOLOGY:

Raghvendra K. Dubey, Stevan P. Tofovic, and Edwin K. Jackson

Cardiovascular Pharmacology of Estradiol Metabolites
J Pharmacol Exp Ther 2004 308: 403-409. Published online December 1, 2003; 10.1124/jpet.103.058057 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

John-Michael Sauer, Amanda J. Long, Barbara Ring, Jennifer S. Gillespie, Nathan P. Sanburn, Karl A. DeSante, David Petullo, Mark R. VandenBranden, Charles B. Jensen, Steven A. Wrighton, Brian P. Smith, Holly A. Read, and Jennifer W. Witcher

Atomoxetine Hydrochloride: Clinical Drug-Drug Interaction Prediction and Outcome
J Pharmacol Exp Ther 2004 308: 410-418. Published online November 10, 2003; 10.1124/jpet.103.058727 [Abstract] [Full Text] [PDF]  

Ande Bao, Beth Goins, Robert Klipper, George Negrete, and William T. Phillips

Direct ^99mTc Labeling of Pegylated Liposomal Doxorubicin (Doxil) for Pharmacokinetic and Non-Invasive Imaging Studies
J Pharmacol Exp Ther 2004 308: 419-425. Published online November 10, 2003; 10.1124/jpet.103.059535 [Abstract] [Full Text] [PDF]  

Takashi Nozawa, Kozue Imai, Jun-Ichi Nezu, Akira Tsuji, and Ikumi Tamai

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human
J Pharmacol Exp Ther 2004 308: 438-445. Published online November 10, 2003; 10.1124/jpet.103.060194 [Abstract] [Full Text] [PDF]  

Scott M. Ocheltree, Hong Shen, Yongjun Hu, Jianming Xiang, Richard F. Keep, and David E. Smith

Mechanisms of Cefadroxil Uptake in the Choroid Plexus: Studies in Wild-Type and PEPT2 Knockout Mice
J Pharmacol Exp Ther 2004 308: 462-467. Published online November 4, 2003; 10.1124/jpet.103.060400 [Abstract] [Full Text] [PDF]  

Yuping Chen, Stephen S. Ferguson, Masahiko Negishi, and Joyce A. Goldstein

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor
J Pharmacol Exp Ther 2004 308: 495-501. Published online November 4, 2003; 10.1124/jpet.103.058818 [Abstract] [Full Text] [PDF]  

Oreste E. Salavaggione, Chen Yang, Linda B. Kidd, Bianca A. Thomae, V. Shane Pankratz, Lauren A. Trepanier, and Richard M. Weinshilboum

Cat Red Blood Cell Thiopurine S-Methyltransferase: Companion Animal Pharmacogenetics
J Pharmacol Exp Ther 2004 308: 617-626. Published online November 10, 2003; 10.1124/jpet.103.059055 [Abstract] [Full Text] [PDF]  

Xueying Yan, Xiangtao Wang, Xuenong Zhang, and Qiang Zhang

Gastrointestinal Absorption of Recombinant Hirudin-2 in Rats
J Pharmacol Exp Ther 2004 308: 774-779. Published online November 10, 2003; 10.1124/jpet.103.056655 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Andrea G. Hohmann, Jesse N. Farthing, Alexander M. Zvonok, and Alexandros Makriyannis

Selective Activation of Cannabinoid CB₂ Receptors Suppresses Hyperalgesia Evoked by Intradermal Capsaicin
J Pharmacol Exp Ther 2004 308: 446-453. Published online November 10, 2003; 10.1124/jpet.103.060079 [Abstract] [Full Text] [PDF]  

Eric W. Fish, Sara Faccidomo, Sandeep Gupta, and Klaus A. Miczek

Anxiolytic-Like Effects of Escitalopram, Citalopram, and R-Citalopram in Maternally Separated Mouse Pups
J Pharmacol Exp Ther 2004 308: 474-480. Published online October 30, 2003; 10.1124/jpet.103.058206 [Abstract] [Full Text] [PDF]  

Kerry E. Culm and Ronald P. Hammer, Jr.

Recovery of Sensorimotor Gating without G Protein Adaptation after Repeated D₂-Like Dopamine Receptor Agonist Treatment in Rats
J Pharmacol Exp Ther 2004 308: 487-494. Published online October 30, 2003; 10.1124/jpet.103.057158 [Abstract] [Full Text] [PDF]  

Xiao-Ying Hua, Carol S. Hayes, Anthony Hofer, Bethany Fitzsimmons, Kalle Kilk, Ülo Langel, Tamas Bartfai, and Tony L. Yaksh

Galanin Acts at GalR1 Receptors in Spinal Antinociception: Synergy with Morphine and AP-5
J Pharmacol Exp Ther 2004 308: 574-582. Published online November 10, 2003; 10.1124/jpet.103.058289 [Abstract] [Full Text] [PDF]  

Christopher M. Butt, Nathan M. King, Jerry A. Stitzel, and Allan C. Collins

Interaction of the Nicotinic Cholinergic System with Ethanol Withdrawal
J Pharmacol Exp Ther 2004 308: 591-599. Published online November 10, 2003; 10.1124/jpet.103.059758 [Abstract] [Full Text] [PDF]  

M. L. Hayward, A. E. Martin, J. F. Brien, H. C. Dringenberg, M. C. Olmstead, and J. N. Reynolds

Chronic Prenatal Ethanol Exposure Impairs Conditioned Responding and Enhances GABA Release in the Hippocampus of the Adult Guinea Pig
J Pharmacol Exp Ther 2004 308: 644-650. Published online November 4, 2003; 10.1124/jpet.103.059261 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Armin Kabat, Klaus Pönicke, Aida Salameh, Friedrich-Wilhelm Mohr, and Stefan Dhein

Effect of a ₂-Adrenoceptor Stimulation on Hyperglycemia-Induced Endothelial Dysfunction
J Pharmacol Exp Ther 2004 308: 564-573. Published online October 30, 2003; 10.1124/jpet.103.057554 [Abstract] [Full Text] [PDF]  

Katsutoshi Yayama, Miyuki Horii, Hiromi Hiyoshi, Masaoki Takano, Hiroshi Okamoto, Satomi Kagota, and Masaru Kunitomo

Up-Regulation of Angiotensin II Type 2 Receptor in Rat Thoracic Aorta by Pressure-Overload
J Pharmacol Exp Ther 2004 308: 736-743. Published online November 10, 2003; 10.1124/jpet.103.058420 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Jesús Pintor, Teresa Peláez, and Assumpta Peral

Adenosine Tetraphosphate, Ap₄, a Physiological Regulator of Intraocular Pressure in Normotensive Rabbit Eyes
J Pharmacol Exp Ther 2004 308: 468-473. Published online November 4, 2003; 10.1124/jpet.103.058669 [Abstract] [Full Text] [PDF]  

Ramin Darbandi-Tonkabon, Brad D. Manion, William R. Hastings, William J. Craigen, Gustav Akk, John R. Bracamontes, Yejun He, Tatiana V. Sheiko, Joseph H. Steinbach, Steven J. Mennerick, Douglas F. Covey, and Alex S. Evers

Neuroactive Steroid Interactions with Voltage-Dependent Anion Channels: Lack of Relationship to GABA_A Receptor Modulation and Anesthesia
J Pharmacol Exp Ther 2004 308: 502-511. Published online October 30, 2003; 10.1124/jpet.103.058123 [Abstract] [Full Text] [PDF]  

Yunxiang Zhu, Xuemei Li, Edward H. Schuchman, Robert J. Desnick, and Seng H. Cheng

Dexamethasone-Mediated Up-Regulation of the Mannose Receptor Improves the Delivery of Recombinant Glucocerebrosidase to Gaucher Macrophages
J Pharmacol Exp Ther 2004 308: 705-711. Published online November 10, 2003; 10.1124/jpet.103.060236 [Abstract] [Full Text] [PDF]  

Hiroyasu Nakata

Stimulation of Extracellular Signal-Regulated Kinase Pathway by Suramin with Concomitant Activation of DNA Synthesis in Cultured Cells
J Pharmacol Exp Ther 2004 308: 744-753. Published online October 30, 2003; 10.1124/jpet.103.058230 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Ming-Yu Cao, Yoon Lee, Ning-Ping Feng, Raed A. Al-Qawasmeh, Stéphane Viau, Xiao-Ping Gu, Leo Lau, Hongnan Jin, Ming Wang, Aikaterini Vassilakos, Jim A. Wright, and Aiping H. Young

NC381, a Novel Anticancer Agent, Arrests the Cell Cycle in G₀-G₁ and Inhibits Lung Tumor Cell Growth in Vitro and in Vivo
J Pharmacol Exp Ther 2004 308: 538-546. Published online November 10, 2003; 10.1124/jpet.103.059618 [Abstract] [Full Text] [PDF]  

Douglas Hagrman, Jerry Goodisman, and Abdul-Kader Souid

Kinetic Study on the Reactions of Platinum Drugs with Glutathione
J Pharmacol Exp Ther 2004 308: 658-666. Published online November 10, 2003; 10.1124/jpet.103.059410 [Abstract] [Full Text] [PDF]  

Naoki Kobayashi, Yumi Matsui, Atsushi Kawase, Kazuhiro Hirata, Makoto Miyagishi, Kazunari Taira, Makiya Nishikawa, and Yoshinobu Takakura

Vector-Based in Vivo RNA Interference: Dose- and Time-Dependent Suppression of Transgene Expression
J Pharmacol Exp Ther 2004 308: 688-693. Published online November 10, 2003; 10.1124/jpet.103.059931 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Edward F. Nemeth, William H. Heaton, Michael Miller, John Fox, Manuel F. Balandrin, Bradford C. Van Wagenen, Mathew Colloton, William Karbon, Jon Scherrer, Edward Shatzen, Gilbert Rishton, Sheila Scully, Meiying Qi, Robert Harris, David Lacey, and David Martin

Pharmacodynamics of the Type II Calcimimetic Compound Cinacalcet HCl
J Pharmacol Exp Ther 2004 308: 627-635. Published online October 30, 2003; 10.1124/jpet.103.057273 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Jian Song, Mark A. Knepper, Xinqun Hu, Joseph G. Verbalis, and Carolyn A. Ecelbarger

Rosiglitazone Activates Renal Sodium- and Water-Reabsorptive Pathways and Lowers Blood Pressure in Normal Rats
J Pharmacol Exp Ther 2004 308: 426-433. Published online October 30, 2003; 10.1124/jpet.103.058008 [Abstract] [Full Text] [PDF]  

Tao Zhang, Jeremy Z. Fields, Saundra M. Ehrlich, and Bruce M. Boman

The Chemopreventive Agent Sulindac Attenuates Expression of the Antiapoptotic Protein Survivin in Colorectal Carcinoma Cells
J Pharmacol Exp Ther 2004 308: 434-437. Published online November 10, 2003; 10.1124/jpet.103.059378 [Abstract] [Full Text] [PDF]  

Florian Loher, Christian Bauer, Nikola Landauer, Kathrin Schmall, Britta Siegmund, Hans Anton Lehr, Marc Dauer, Martin Schoenharting, Stefan Endres, and Andreas Eigler

The Interleukin-1-Converting Enzyme Inhibitor Pralnacasan Reduces Dextran Sulfate Sodium-Induced Murine Colitis and T Helper 1 T-Cell Activation
J Pharmacol Exp Ther 2004 308: 583-590. Published online November 10, 2003; 10.1124/jpet.103.057059 [Abstract] [Full Text] [PDF]  

David Sacerdoti, Nader G. Abraham, Adebayo O. Oyekan, Liming Yang, Angelo Gatta, and John C. McGiff

Role of the Heme Oxygenases in Abnormalities of the Mesenteric Circulation in Cirrhotic Rats
J Pharmacol Exp Ther 2004 308: 636-643. Published online November 4, 2003; 10.1124/jpet.103.057315 [Abstract] [Full Text] [PDF]  

Fiona R. Coulson, David B. Jacoby, and Allison D. Fryer

Insulin Regulates Neuronal M₂ Muscarinic Receptor Function in the Ileum of Diabetic Rats
J Pharmacol Exp Ther 2004 308: 760-766. Published online November 10, 2003; 10.1124/jpet.103.057570 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Regina Draheim, Ute Egerland, and Chris Rundfeldt

Anti-Inflammatory Potential of the Selective Phosphodiesterase 4 Inhibitor N-(3,5-Dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic Acid Amide (AWD 12-281), in Human Cell Preparations
J Pharmacol Exp Ther 2004 308: 555-563. Published online November 10, 2003; 10.1124/jpet.103.059097 [Abstract] [Full Text] [PDF]  

Sonja von Aulock, Eva-Maria Boneberg, Isabel Diterich, and Thomas Hartung

Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Primes for Increased ex Vivo Inducible Prostanoid Release
J Pharmacol Exp Ther 2004 308: 754-759. Published online November 10, 2003; 10.1124/jpet.103.058198 [Abstract] [Full Text] [PDF]  

Salahuddin Ahmed, Naizhen Wang, Mathew Lalonde, Victor M. Goldberg, and Tariq M. Haqqi

Green Tea Polyphenol Epigallocatechin-3-gallate (EGCG) Differentially Inhibits Interleukin-1-Induced Expression of Matrix Metalloproteinase-1 and -13 in Human Chondrocytes
J Pharmacol Exp Ther 2004 308: 767-773. Published online November 4, 2003; 10.1124/jpet.103.059220 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Paola F. Zaratin, Giuseppe Petrone, Massimo Sbacchi, Martine Garnier, Claudia Fossati, Paola Petrillo, Silvio Ronzoni, Giuseppe A. M. Giardina, and Mark A. Scheideler

Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)
J Pharmacol Exp Ther 2004 308: 454-461. Published online October 30, 2003; 10.1124/jpet.103.055848 [Abstract] [Full Text] [PDF]  

Qian Li, Li Ma, Robert B. Innis, Nicholas Seneca, Masanori Ichise, Henry Huang, Marc Laruelle, and Dennis L. Murphy

Pharmacological and Genetic Characterization of Two Selective Serotonin Transporter Ligands: 2-[2-(Dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-Amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB)
J Pharmacol Exp Ther 2004 308: 481-486. Published online November 10, 2003; 10.1124/jpet.103.058636 [Abstract] [Full Text] [PDF]  

Danxin Wang, Kirsten M. Raehal, Emil T. Lin, John J. Lowery, Brigitte L. Kieffer, Edward J. Bilsky, and Wolfgang Sadée

Basal Signaling Activity of µ Opioid Receptor in Mouse Brain: Role in Narcotic Dependence
J Pharmacol Exp Ther 2004 308: 512-520. Published online November 4, 2003; 10.1124/jpet.103.054049 [Abstract] [Full Text] [PDF]  

Victoria B. Kane, Yitong Fu, Shannon G. Matta, and Burt M. Sharp

Gestational Nicotine Exposure Attenuates Nicotine-Stimulated Dopamine Release in the Nucleus Accumbens Shell of Adolescent Lewis Rats
J Pharmacol Exp Ther 2004 308: 521-528. Published online November 10, 2003; 10.1124/jpet.103.059899 [Abstract] [Full Text] [PDF]  

Melissa C. Rhodes, Frederic J. Seidler, Ali Abdel-Rahman, Charlotte A. Tate, Abraham Nyska, Heather L. Rincavage, and Theodore A. Slotkin

Terbutaline Is a Developmental Neurotoxicant: Effects on Neuroproteins and Morphology in Cerebellum, Hippocampus, and Somatosensory Cortex
J Pharmacol Exp Ther 2004 308: 529-537. Published online November 10, 2003; 10.1124/jpet.103.060095 [Abstract] [Full Text] [PDF]  

Chad M. Thompson, Heidi Wojno, Elisabeth Greiner, Everette L. May, Kenner C. Rice, and Dana E. Selley

Activation of G-Proteins by Morphine and Codeine Congeners: Insights to the Relevance of O- and N-Demethylated Metabolites at µ- and -Opioid Receptors
J Pharmacol Exp Ther 2004 308: 547-554. Published online November 4, 2003; 10.1124/jpet.103.058602 [Abstract] [Full Text] [PDF]  

Ester Verdaguer, Andrés Jiménez, Anna M. Canudas, Elvira G. Jordà, F. Xavier Sureda, Mercè Pallàs, and Antoni Camins

Inhibition of Cell Cycle Pathway by Flavopiridol Promotes Survival of Cerebellar Granule Cells after an Excitotoxic Treatment
J Pharmacol Exp Ther 2004 308: 609-616. Published online November 10, 2003; 10.1124/jpet.103.057497 [Abstract] [Full Text] [PDF]  

Kimberly A. Leite-Morris, Eugene Y. Fukudome, Marwa H. Shoeb, and Gary B. Kaplan

GABA_B Receptor Activation in the Ventral Tegmental Area Inhibits the Acquisition and Expression of Opiate-Induced Motor Sensitization
J Pharmacol Exp Ther 2004 308: 667-678. Published online November 10, 2003; 10.1124/jpet.103.058412 [Abstract] [Full Text] [PDF]  

David L. Roman, Shannon N. Saldaña, David E. Nichols, F. Ivy Carroll, and Eric L. Barker

Distinct Molecular Recognition of Psychostimulants by Human and Drosophila Serotonin Transporters
J Pharmacol Exp Ther 2004 308: 679-687. Published online October 30, 2003; 10.1124/jpet.103.057836 [Abstract] [Full Text] [PDF]  

Mohammed A. Shaqura, Christian Zöllner, Shaaban A. Mousa, Christoph Stein, and Michael Schäfer

Characterization of µ Opioid Receptor Binding and G Protein Coupling in Rat Hypothalamus, Spinal Cord, and Primary Afferent Neurons during Inflammatory Pain
J Pharmacol Exp Ther 2004 308: 712-718. Published online October 30, 2003; 10.1124/jpet.103.057257 [Abstract] [Full Text] [PDF]  

S. M. Rawls, R. J. Tallarida, A. M. Gray, Ellen B. Geller, and Martin W. Adler

L-NAME (N-Nitro-L-Arginine Methyl Ester), a Nitric-Oxide Synthase Inhibitor, and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one], a Cannabinoid Agonist, Interact to Evoke Synergistic Hypothermia
J Pharmacol Exp Ther 2004 308: 780-786. Published online November 10, 2003; 10.1124/jpet.103.054668 [Abstract] [Full Text] [PDF]  

M. A. Rigoulot, E. Koning, A. Ferrandon, and A. Nehlig

Neuroprotective Properties of Topiramate in the Lithium-Pilocarpine Model of Epilepsy
J Pharmacol Exp Ther 2004 308: 787-795. Published online October 30, 2003; 10.1124/jpet.103.057091 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

W. James Gilmore and Gordon M. Kirby

Endoplasmic Reticulum Stress Due to Altered Cellular Redox Status Positively Regulates Murine Hepatic CYP2A5 Expression
J Pharmacol Exp Ther 2004 308: 600-608. Published online November 10, 2003; 10.1124/jpet.103.060111 [Abstract] [Full Text] [PDF]  

Yasushi Ito, Masami Son, Shinji Sato, Takamasa Ohashi, Masashi Kondo, Kaoru Shimokata, and Hiroaki Kume

Effects of Fluoranthene, a Polycyclic Aromatic Hydrocarbon, on cAMP-Dependent Anion Secretion in Human Airway Epithelia
J Pharmacol Exp Ther 2004 308: 651-657. Published online November 10, 2003; 10.1124/jpet.103.059089 [Abstract] [Full Text] [PDF]  

Sharmilee P. Sawant, Ankur V. Dnyanmote, Kartik Shankar, Pallavi B. Limaye, John R. Latendresse, and Harihara M. Mehendale

Potentiation of Carbon Tetrachloride Hepatotoxicity and Lethality in Type 2 Diabetic Rats
J Pharmacol Exp Ther 2004 308: 694-704. Published online November 10, 2003; 10.1124/jpet.103.058834 [Abstract] [Full Text] [PDF]  

Xiaoliang Zhuo, Jun Gu, Melissa J. Behr, Pam J. Swiatek, Huadong Cui, Qing-Yu Zhang, Yingqiu Xie, Doris N. Collins, and Xinxin Ding

Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects on Cyp2a5 Expression
J Pharmacol Exp Ther 2004 308: 719-728. Published online November 10, 2003; 10.1124/jpet.103.060301 [Abstract] [Full Text] [PDF]  

Yukiko Minamiyama, Shigekazu Takemura, Keiichi Yamasaki, Seikan Hai, Kazuhiro Hirohashi, Yoshihiko Funae, and Shigeru Okada

Continuous Administration of Organic Nitrate Decreases Hepatic Cytochrome P450
J Pharmacol Exp Ther 2004 308: 729-735. Published online October 30, 2003; 10.1124/jpet.103.057877 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Extended in Vivo Pharmacodynamic Activity of E5564 (-D-Glucopyranose) in Normal Volunteers with Experimental Endotoxemia"
J Pharmacol Exp Ther 2004 308: 796. [Full Text] [PDF]  

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