EDITORIAL:

Rick G. Schnellmann

Editorial
J Pharmacol Exp Ther 2004 308: 1. Published online November 6, 2003; 10.1124/jpet.103.062497 [Full Text] [PDF]  

PERSPECTIVES IN PHARMACOLOGY:

Johan W. Jonker and Alfred H. Schinkel

Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters: OCT1, 2, and 3 (SLC22A1-3)
J Pharmacol Exp Ther 2004 308: 2-9. Published online October 23, 2003; 10.1124/jpet.103.053298 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Hiroko Kawaguchi, Yumi Matsui, Yoshihiko Watanabe, and Yoshinobu Takakura

Effect of Interferon- on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse
J Pharmacol Exp Ther 2004 308: 91-96. Published online October 20, 2003; 10.1124/jpet.103.057521 [Abstract] [Full Text] [PDF]  

Carolyn L. Cummins, Wolfgang Jacobsen, Uwe Christians, and Leslie Z. Benet

CYP3A4-Transfected Caco-2 Cells as a Tool for Understanding Biochemical Absorption Barriers: Studies with Sirolimus and Midazolam
J Pharmacol Exp Ther 2004 308: 143-155. Published online October 20, 2003; 10.1124/jpet.103.058065 [Abstract] [Full Text] [PDF]  

Tanja Richter, Thomas E. Mürdter, Georg Heinkele, Jürgen Pleiss, Stephan Tatzel, Matthias Schwab, Michel Eichelbaum, and Ulrich M. Zanger

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine
J Pharmacol Exp Ther 2004 308: 189-197. Published online October 16, 2003; 10.1124/jpet.103.056127 [Abstract] [Full Text] [PDF]  

Gerhard A. Siebert, Daniel Y. Hung, Ping Chang, and Michael S. Roberts

Ion-Trapping, Microsomal Binding, and Unbound Drug Distribution in the Hepatic Retention of Basic Drugs
J Pharmacol Exp Ther 2004 308: 228-235. Published online October 17, 2003; 10.1124/jpet.103.056770 [Abstract] [Full Text] [PDF]  

Norie Murayama, Akiko Soyama, Yoshiro Saito, Yukiko Nakajima, Kazuo Komamura, Kazuyuki Ueno, Shiro Kamakura, Masafumi Kitakaze, Hideo Kimura, Yu-ichi Goto, Osamu Saitoh, Masaaki Katoh, Teiichi Ohnuma, Mitsuru Kawai, Kenji Sugai, Taisuke Ohtsuki, Chieko Suzuki, Narihiro Minami, Shogo Ozawa, and Jun-ichi Sawada

Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms: Catalytic Activities of the Naturally Occurring Variant Enzymes
J Pharmacol Exp Ther 2004 308: 300-306. Published online October 16, 2003; 10.1124/jpet.103.055798 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Lance R. McMahon, Stacy L. Sell, and Charles P. France

Cocaine and Other Indirect-Acting Monoamine Agonists Differentially Attenuate a Naltrexone Discriminative Stimulus in Morphine-Treated Rhesus Monkeys
J Pharmacol Exp Ther 2004 308: 111-119. Published online October 20, 2003; 10.1124/jpet.103.058917 [Abstract] [Full Text] [PDF]  

Lawrence P. Carter, Huifang Wu, Weibin Chen, Christopher M. Cruz, R. J. Lamb, Wouter Koek, Andy Coop, and Charles P. France

Effects of -Hydroxybutyrate (GHB) on Schedule-Controlled Responding in Rats: Role of GHB and GABA_B Receptors
J Pharmacol Exp Ther 2004 308: 182-188. Published online October 20, 2003; 10.1124/jpet.103.058909 [Abstract] [Full Text] [PDF]  

Maciej Gasior, Carol A. Paronis, and Jack Bergman

Modification by Dopaminergic Drugs of Choice Behavior under Concurrent Schedules of Intravenous Saline and Food Delivery in Monkeys
J Pharmacol Exp Ther 2004 308: 249-259. Published online October 16, 2003; 10.1124/jpet.103.052795 [Abstract] [Full Text] [PDF]  

Osama M. Abo-Salem, Alaa M. Hayallah, Andras Bilkei-Gorzo, Barbara Filipek, Andreas Zimmer, and Christa E. Müller

Antinociceptive Effects of Novel A_2B Adenosine Receptor Antagonists
J Pharmacol Exp Ther 2004 308: 358-366. Published online October 16, 2003; 10.1124/jpet.103.056036 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Sean A. Cahill and Gil J. Gross

Propafenone and Its Metabolites Preferentially Inhibit I_Krin Rabbit Ventricular Myocytes
J Pharmacol Exp Ther 2004 308: 59-65. Published online October 20, 2003; 10.1124/jpet.103.057844 [Abstract] [Full Text] [PDF]  

Kathryn K. Chadman and James H. Woods

Cardiovascular Effects of Nicotine, Chlorisondamine, and Mecamylamine in the Pigeon
J Pharmacol Exp Ther 2004 308: 73-78. Published online October 17, 2003; 10.1124/jpet.103.057307 [Abstract] [Full Text] [PDF]  

Giuseppe Rossoni, Monica Gomaraschi, Ferruccio Berti, Cesare R. Sirtori, Guido Franceschini, and Laura Calabresi

Synthetic High-Density Lipoproteins Exert Cardioprotective Effects in Myocardial Ischemia/Reperfusion Injury
J Pharmacol Exp Ther 2004 308: 79-84. Published online October 17, 2003; 10.1124/jpet.103.057141 [Abstract] [Full Text] [PDF]  

I. Tong Mak and William B. Weglicki

Potent Antioxidant Properties of 4-Hydroxyl-propranolol
J Pharmacol Exp Ther 2004 308: 85-90. Published online October 20, 2003; 10.1124/jpet.103.058032 [Abstract] [Full Text] [PDF]  

B. Brandts, R. Borchard, R. Macianskiene, V. Gendviliene, D. Dirkmann, M. Van Bracht, M. Prull, M. Meine, I. Wickenbrock, K. Mubagwa, and H.-J. Trappe

Inhibition of G Protein-Coupled and ATP-Sensitive Potassium Currents by 2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015), an Amiodarone Derivative
J Pharmacol Exp Ther 2004 308: 134-142. Published online October 20, 2003; 10.1124/jpet.103.057646 [Abstract] [Full Text] [PDF]  

Vangelis Karalis, Aristides Dokoumetzidis, and Panos Macheras

A Physiologically Based Approach for the Estimation of Recirculatory Parameters
J Pharmacol Exp Ther 2004 308: 198-205. Published online October 20, 2003; 10.1124/jpet.103.058941 [Abstract] [Full Text] [PDF]  

Patrice Colin, Bijan Ghaleh, Xavier Monnet, Luc Hittinger, and Alain Berdeaux

Effect of Graded Heart Rate Reduction with Ivabradine on Myocardial Oxygen Consumption and Diastolic Time in Exercising Dogs
J Pharmacol Exp Ther 2004 308: 236-240. Published online October 20, 2003; 10.1124/jpet.103.059717 [Abstract] [Full Text] [PDF]  

G. Abou-Mohamed, J. A. Johnson, L. Jin, A. B. El-Remessy, K. Do, W. H. Kaesemeyer, R. B. Caldwell, and R. W. Caldwell

Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin
J Pharmacol Exp Ther 2004 308: 289-299. Published online October 16, 2003; 10.1124/jpet.103.056119 [Abstract] [Full Text] [PDF]  

Zhi Su, Michael Sheets, Hideyuki Ishida, Fenghua Li, and William H. Barry

Saxitoxin Blocks L-Type I_Ca
J Pharmacol Exp Ther 2004 308: 324-329. Published online October 17, 2003; 10.1124/jpet.103.056564 [Abstract] [Full Text] [PDF]  

Alex A. Pérez-Rivera, Gregory D. Fink, and James J. Galligan

Increased Reactivity of Murine Mesenteric Veins to Adrenergic Agonists: Functional Evidence Supporting Increased ₁-Adrenoceptor Reserve in Veins Compared with Arteries
J Pharmacol Exp Ther 2004 308: 350-357. Published online October 30, 2003; 10.1124/jpet.103.056184 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Ki Young Kim, Hwa Kyoung Shin, Jeong Hyun Lee, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim, Yung Woo Shin, and Ki Whan Hong

Cilostazol Enhances Casein Kinase 2 Phosphorylation and Suppresses Tumor Necrosis Factor--Induced Increased Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation and Apoptotic Cell Death in SK-N-SH Cells
J Pharmacol Exp Ther 2004 308: 97-104. Published online October 20, 2003; 10.1124/jpet.103.058768 [Abstract] [Full Text] [PDF]  

Jan Jakubík, Stanislav Tucek, and Esam E. El-Fakahany

Role of Receptor Protein and Membrane Lipids in Xanomeline Wash-Resistant Binding to Muscarinic M₁ Receptors
J Pharmacol Exp Ther 2004 308: 105-110. Published online October 20, 2003; 10.1124/jpet.103.058594 [Abstract] [Full Text] [PDF]  

Pamela K. Smitherman, Alan J. Townsend, Timothy E. Kute, and Charles S. Morrow

Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates Glutathione S-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity
J Pharmacol Exp Ther 2004 308: 260-267. Published online October 20, 2003; 10.1124/jpet.103.057729 [Abstract] [Full Text] [PDF]  

Tetsuya Yamamoto, Jill Lewis, John Wataha, Douglas Dickinson, Baldev Singh, Wendy B. Bollag, Eisaku Ueta, Tokio Osaki, Mohammad Athar, George Schuster, and Stephen Hsu

Roles of Catalase and Hydrogen Peroxide in Green Tea Polyphenol-Induced Chemopreventive Effects
J Pharmacol Exp Ther 2004 308: 317-323. Published online October 20, 2003; 10.1124/jpet.103.058891 [Abstract] [Full Text] [PDF]  

Michael T. Griffin, Minoru Matsui, Darakhshanda Shehnaz, Khurram Z. Ansari, Makoto M. Taketo, Toshiya Manabe, and Frederick J. Ehlert

Muscarinic Agonist-Mediated Heterologous Desensitization in Isolated Ileum Requires Activation of Both Muscarinic M₂ and M₃ Receptors
J Pharmacol Exp Ther 2004 308: 339-349. Published online October 16, 2003; 10.1124/jpet.103.055327 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Takanori Akagi, Kazami Ushinohama, Shoko Ikesue, Eiji Yukawa, Shun Higuchi, Kenji Hamase, Kiyoshi Zaitsu, and Shigehiro Ohdo

Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect
J Pharmacol Exp Ther 2004 308: 378-384. Published online October 16, 2003; 10.1124/jpet.103.055657 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Nancy K. Mello, Jack H. Mendelson, S. Stevens Negus, and Maureen Kelly

Ovarian Steroid Hormone Modulation of the Acute Effects of Cocaine on Luteinizing Hormone and Prolactin Levels in Ovariectomized Rhesus Monkeys
J Pharmacol Exp Ther 2004 308: 156-167. Published online October 17, 2003; 10.1124/jpet.103.057216 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Jeffrey S. Fedan, Janet A. Dowdy, Richard A. Johnston, and Michael R. Van Scott

Hyperosmolar Solution Effects in Guinea Pig Airways. I. Mechanical Responses to Relative Changes in Osmolarity
J Pharmacol Exp Ther 2004 308: 10-18. Published online October 16, 2003; 10.1124/jpet.103.051607 [Abstract] [Full Text] [PDF]  

David X.-Y. Wu, Richard A. Johnston, Appavoo Rengasamy, Michael R. Van Scott, and Jeffrey S. Fedan

Hyperosmolar Solution Effects in Guinea Pig Airways. II. Epithelial Bioelectric Responses to Relative Changes in Osmolarity
J Pharmacol Exp Ther 2004 308: 19-29. Published online October 17, 2003; 10.1124/jpet.103.051615 [Abstract] [Full Text] [PDF]  

Jeffrey S. Fedan, Janet A. Dowdy, Michael R. Van Scott, David X.-Y. Wu, and Richard A. Johnston

Hyperosmolar Solution Effects in Guinea Pig Airways. III. Studies on the Identity of Epithelium-Derived Relaxing Factor in Isolated Perfused Trachea Using Pharmacological Agents
J Pharmacol Exp Ther 2004 308: 30-36. Published online October 17, 2003; 10.1124/jpet.103.051664 [Abstract] [Full Text] [PDF]  

Richard A. Johnston, Michael R. Van Scott, Choudari Kommineni, Lyndell L. Millecchia, Juanita Dortch-Carnes, and Jeffrey S. Fedan

Hyperosmolar Solution Effects in Guinea Pig Airways. IV. Lipopolysaccharide-Induced Alterations in Airway Reactivity and Epithelial Bioelectric Responses to Methacholine and Hyperosmolarity
J Pharmacol Exp Ther 2004 308: 37-46. Published online October 17, 2003; 10.1124/jpet.103.051672 [Abstract] [Full Text] [PDF]  

Tim Schneider, Peter Hein, and Martin C. Michel

Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. I. Phospholipases and Ca²⁺ Sources
J Pharmacol Exp Ther 2004 308: 47-53. Published online October 7, 2003; 10.1124/jpet.103.058248 [Abstract] [Full Text] [PDF]  

Marina Fleichman, Tim Schneider, Charlotte Fetscher, and Martin C. Michel

Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. II. Protein Kinases
J Pharmacol Exp Ther 2004 308: 54-58. Published online October 7, 2003; 10.1124/jpet.103.058255 [Abstract] [Full Text] [PDF] Supplemental Figure 1Supplemental Figure 2Supplemental Figure 3Supplemental Figure 4Supplemental Figure 5Supplemental Figure 6  

Yi N. Ye, Edgar S. L. Liu, Vivian Y. Shin, William K. K. Wu, Jiing C. Luo, and Chi H. Cho

Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway
J Pharmacol Exp Ther 2004 308: 66-72. Published online October 20, 2003; 10.1124/jpet.103.058321 [Abstract] [Full Text] [PDF]  

Kenichi Kanoh, Tatsuo Shimura, Hideki Suzuki, Kenichi Nomoto, Takayuki Asao, and Hiroyuki Kuwano

Antitumor Effect of a Splenic Injection of 5-Fluorouracil on Metastatic Liver Cancer in Mice
J Pharmacol Exp Ther 2004 308: 168-174. Published online October 20, 2003; 10.1124/jpet.103.057547 [Abstract] [Full Text] [PDF]  

Kalina Venkova, James C. Keith, Jr., and Beverley Greenwood-Van Meerveld

Oral Treatment with Recombinant Human Interleukin-11 Improves Mucosal Transport in the Colon of Human Leukocyte Antigen-B27 Transgenic Rats
J Pharmacol Exp Ther 2004 308: 206-213. Published online October 20, 2003; 10.1124/jpet.103.058701 [Abstract] [Full Text] [PDF]  

Gennadi M. Kravtsov, Isabel S. S. Hwang, and Fai Tang

The Inhibitory Effect of Adrenomedullin in the Rat Ileum: Cross-Talk with ₃-Adrenoceptor in the Serotonin-Induced Muscle Contraction
J Pharmacol Exp Ther 2004 308: 241-248. Published online October 20, 2003; 10.1124/jpet.103.057612 [Abstract] [Full Text] [PDF]  

Karlheinz Ehrlich, Christa Sicking, Michael Respondek, and Brigitta M. Peskar

Interaction of Cyclooxygenase Isoenzymes, Nitric Oxide, and Afferent Neurons in Gastric Mucosal Defense in Rats
J Pharmacol Exp Ther 2004 308: 277-283. Published online October 20, 2003; 10.1124/jpet.103.057752 [Abstract] [Full Text] [PDF]  

DeWayne Townsend, IV, Philip S. Portoghese, and David R. Brown

Characterization of Specific Opioid Binding Sites in Neural Membranes from the Myenteric Plexus of Porcine Small Intestine
J Pharmacol Exp Ther 2004 308: 385-393. Published online October 20, 2003; 10.1124/jpet.103.058016 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Melvyn Lynn, Y. Nancy Wong, Janice L. Wheeler, Richard J. Kao, Carlos A. Perdomo, Robert Noveck, Ramon Vargas, Tony D'Angelo, Sandra Gotzkowsky, F. Gilbert McMahon, Kishor M. Wasan, and Daniel P. Rossignol

Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia
J Pharmacol Exp Ther 2004 308: 175-181. Published online October 17, 2003; 10.1124/jpet.103.056531 [Abstract] [Full Text] [PDF]  

Robin L. Thurmond, Siquan Sun, Clark A. Sehon, Sherry M. Baker, Hui Cai, Yin Gu, Wen Jiang, Jason P. Riley, Kacy N. Williams, James P. Edwards, and Lars Karlsson

Identification of a Potent and Selective Noncovalent Cathepsin S Inhibitor
J Pharmacol Exp Ther 2004 308: 268-276. Published online October 17, 2003; 10.1124/jpet.103.056879 [Abstract] [Full Text] [PDF]  

Mingchen Song, John A. Kellum, Hoda Kaldas, and Mitchell P. Fink

Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured Lipopolysaccharide-Stimulated RAW 264.7 Cells
J Pharmacol Exp Ther 2004 308: 307-316. Published online October 20, 2003; 10.1124/jpet.103.056622 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Feng Wang, Nobuya Matsuoka, Seitaro Mutoh, and Shuji Kaneko

Modulation of Ca²⁺Channel Currents by a Novel Antidementia DrugN-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960) in Rat Hippocampal Neurons
J Pharmacol Exp Ther 2004 308: 120-126. Published online October 20, 2003; 10.1124/jpet.103.057687 [Abstract] [Full Text] [PDF]  

Hiroshi Yamashita, Kazushige Ohno, Yoko Amada, Hanae Hattori, Yukiko Ozawa-Funatsu, Takashi Toya, Hiroshi Inami, Jun-Ichi Shishikura, Shuichi Sakamoto, Masamichi Okada, and Tokio Yamaguchi

Effects of 2-[N-(4-Chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an Orally Active -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist, in Models of Generalized Epileptic Seizure in Mice and Rats
J Pharmacol Exp Ther 2004 308: 127-133. Published online October 20, 2003; 10.1124/jpet.103.058495 [Abstract] [Full Text] [PDF]  

Susan E. Hanak, Erin M. Reilly, Jill Wotanis, Bin Zhu, Claudine Pulicicchio, Kathleen McMonagle-Strucko, Joseph G. Wettstein, and Mark D. Black

An Electrophysiological Model of Spinal Transmission Deficits in Mouse Experimental Autoimmune Encephalomyelitis
J Pharmacol Exp Ther 2004 308: 214-220. Published online October 17, 2003; 10.1124/jpet.103.056994 [Abstract] [Full Text] [PDF]  

Timothy A. Vortherms and Val J. Watts

Sensitization of Neuronal A_2A Adenosine Receptors after Persistent D₂ Dopamine Receptor Activation
J Pharmacol Exp Ther 2004 308: 221-227. Published online October 17, 2003; 10.1124/jpet.103.057083 [Abstract] [Full Text] [PDF]  

Gin C. Hsieh, Peter R. Hollingsworth, Brenda Martino, Renjie Chang, Marc A. Terranova, Alyssa B. O'Neill, James J. Lynch, Robert B. Moreland, Diana L. Donnelly-Roberts, Teodozyi Kolasa, Joseph P. Mikusa, Jill M. McVey, Kennan C. Marsh, James P. Sullivan, and Jorge D. Brioni

Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine
J Pharmacol Exp Ther 2004 308: 330-338. Published online October 20, 2003; 10.1124/jpet.103.057455 [Abstract] [Full Text] [PDF]  

Lisa S. Middleton, Wayne A. Cass, and Linda P. Dwoskin

Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex
J Pharmacol Exp Ther 2004 308: 367-377. Published online October 16, 2003; 10.1124/jpet.103.055335 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Ling O. Qiu, Mark W. Linder, Deborah M. Antonino-Green, and Roland Valdes, Jr.

Suppression of Cytochrome P450 2E1 Promoter Activity by Interferon- and Loss of Response Due to the -71G>T Nucleotide Polymorphism of the CYP2E1^*7B Allele
J Pharmacol Exp Ther 2004 308: 284-288. Published online October 17, 2003; 10.1124/jpet.103.057208 [Abstract] [Full Text] [PDF]  

F. Pouzaud, K. Bernard-Beaubois, M. Thevenin, J.-M. Warnet, G. Hayem, and P. Rat

In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress
J Pharmacol Exp Ther 2004 308: 394-402. Published online October 20, 2003; 10.1124/jpet.103.057984 [Abstract] [Full Text] [PDF]  

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