PERSPECTIVES IN PHARMACOLOGY:

Joann Trejo

Protease-Activated Receptors: New Concepts in Regulation of G Protein-Coupled Receptor Signaling and Trafficking
J Pharmacol Exp Ther 2003 307: 437-442. Published online September 9, 2003; 10.1124/jpet.103.052100 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Jeffrey C. Stevens, Ronald N. Hines, Chungang Gu, Sevasti B. Koukouritaki, Jason R. Manro, Peter J. Tandler, and Matthew J. Zaya

Developmental Expression of the Major Human Hepatic CYP3A Enzymes
J Pharmacol Exp Ther 2003 307: 573-582. Published online September 15, 2003; 10.1124/jpet.103.054841 [Abstract] [Full Text] [PDF]  

Xiaoyue Pan, Tomohiro Terada, Masahiro Okuda, and Ken-Ichi Inui

Altered Diurnal Rhythm of Intestinal Peptide Transporter by Fasting and Its Effects on the Pharmacokinetics of Ceftibuten
J Pharmacol Exp Ther 2003 307: 626-632. Published online September 11, 2003; 10.1124/jpet.103.055939 [Abstract] [Full Text] [PDF]  

Jaya Bharathi Vaidyanathan and Thomas Walle

Cellular Uptake and Efflux of the Tea Flavonoid (-)Epicatechin-3-gallate in the Human Intestinal Cell Line Caco-2
J Pharmacol Exp Ther 2003 307: 745-752. Published online September 11, 2003; 10.1124/jpet.103.054296 [Abstract] [Full Text] [PDF]  

Sangeeta Raje, Jianjing Cao, Amy Hauck Newman, Huanling Gao, and Natalie D. Eddington

Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques
J Pharmacol Exp Ther 2003 307: 801-808. Published online September 9, 2003; 10.1124/jpet.103.053504 [Abstract] [Full Text] [PDF]  

Akinobu Hamada, Hideto Miyano, Hiroshi Watanabe, and Hideyuki Saito

Interaction of Imatinib Mesilate with Human P-Glycoprotein
J Pharmacol Exp Ther 2003 307: 824-828. Published online September 15, 2003; 10.1124/jpet.103.055574 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Mark D. Lindner, Donald B. Hodges, Jr., John B. Hogan, Anitra F. Orie, Jason A. Corsa, Donna M. Barten, Craig Polson, Barbara J. Robertson, Valerie L. Guss, Kevin W. Gillman, John E. Starrett, Jr., and Valentin K. Gribkoff

An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning
J Pharmacol Exp Ther 2003 307: 682-691. Published online September 15, 2003; 10.1124/jpet.103.056002 [Abstract] [Full Text] [PDF]  

Richard M. Allen, Arthur L. Granger, and Linda A. Dykstra

The Competitive N-Methyl-D-aspartate Receptor Antagonist (-)-6-Phosphonomethyl-deca-hydroisoquinoline-3-carboxylic Acid (LY235959) Potentiates the Antinociceptive Effects of Opioids That Vary in Efficacy at the µ-Opioid Receptor
J Pharmacol Exp Ther 2003 307: 785-792. Published online September 15, 2003; 10.1124/jpet.103.055319 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Horacio Vidrio, Martha Medina, Pilar González-Romo, Marte Lorenzana-Jiménez, Patricia Díaz-Arista, and Alejandro Baeza

Semicarbazide-Sensitive Amine Oxidase Substrates Potentiate Hydralazine Hypotension: Possible Role of Hydrogen Peroxide
J Pharmacol Exp Ther 2003 307: 497-504. Published online September 11, 2003; 10.1124/jpet.103.055350 [Abstract] [Full Text] [PDF]  

Charles Plut, Catherine Ribière, Yves Giudicelli, and Jean-Pierre Dausse

Hypothalamic Leptin Receptor and Signaling Molecule Expressions in Cafeteria Diet-Fed Rats
J Pharmacol Exp Ther 2003 307: 544-549. Published online September 9, 2003; 10.1124/jpet.103.054726 [Abstract] [Full Text] [PDF]  

Diethart Schmid, Dawid L. Staudacher, Hans G. Loew, Paul G. Spieckermann, Gerhard F. Ecker, Stephan Kopp, and Peter Chiba

A Subset of Highly Effective Propafenone-Type Multidrug Resistance Modulators Lacks Effects on Cardiac Action Potential and Mechanical Twitch Parameters of Rat Papillary Muscles
J Pharmacol Exp Ther 2003 307: 589-596. Published online September 9, 2003; 10.1124/jpet.103.052993 [Abstract] [Full Text] [PDF]  

Gabor Varbiro, Ambrus Toth, Antal Tapodi, Zita Bognar, Balazs Veres, Balazs Sumegi, and Ferenc Gallyas, Jr.

Protective Effect of Amiodarone but Not N- Desethylamiodarone on Postischemic Hearts through the Inhibition of Mitochondrial Permeability Transition
J Pharmacol Exp Ther 2003 307: 615-625. Published online September 11, 2003; 10.1124/jpet.103.053553 [Abstract] [Full Text] [PDF]  

Giuseppe Rossoni, Barbara Manfredi, Viviana Cavalca, Roberta Razzetti, Stefano Bongrani, Gian Luca Polvani, and Ferruccio Berti

The Aminotetraline Derivative (±)-(R,S)-5,6-Dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene Hydrochloride (CHF-1024) Displays Cardioprotection in Postischemic Ventricular Dysfunction of the Rat Heart
J Pharmacol Exp Ther 2003 307: 633-639. Published online September 15, 2003; 10.1124/jpet.103.054700 [Abstract] [Full Text] [PDF]  

Hong Wang, Li Lin, Jiangang Jiang, Yan Wang, Zai Ying Lu, J. Alyce Bradbury, Fred Bjørn Lih, Dao Wen Wang, and Darryl C. Zeldin

Up-Regulation of Endothelial Nitric-Oxide Synthase by Endothelium-Derived Hyperpolarizing Factor Involves Mitogen-Activated Protein Kinase and Protein Kinase C Signaling Pathways
J Pharmacol Exp Ther 2003 307: 753-764. Published online September 15, 2003; 10.1124/jpet.103.052787 [Abstract] [Full Text] [PDF]  

Morten B. Thomsen, Paul G. A. Volders, Milan Stengl, Roel L. H. M. G. Späatjens, Jet D. M. Beekman, Ulrike Bischoff, Morten A. Kall, Kristen Frederiksen, Jørgen Matz, and Marc A. Vos

Electrophysiological Safety of Sertindole in Dogs with Normal and Remodeled Hearts
J Pharmacol Exp Ther 2003 307: 776-784. Published online September 9, 2003; 10.1124/jpet.103.052753 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Katherine G. Moss, Guy C. Toner, Julie M. Cherrington, Dirk B. Mendel, and A. Douglas Laird

Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans
J Pharmacol Exp Ther 2003 307: 476-480. Published online September 9, 2003; 10.1124/jpet.103.052530 [Abstract] [Full Text] [PDF]  

Susan R. George, Gordon Y. K. Ng, Samuel P. Lee, Theresa Fan, George Varghese, Chen Wang, Charles M. Deber, Philip Seeman, and Brian F. O'Dowd

Blockade of G Protein-Coupled Receptors and the Dopamine Transporter by a Transmembrane Domain Peptide: Novel Strategy for Functional Inhibition of Membrane Proteins in Vivo
J Pharmacol Exp Ther 2003 307: 481-489. Published online September 11, 2003; 10.1124/jpet.103.053843 [Abstract] [Full Text] [PDF]  

Eun Joung Kim, Ki Sook Park, Soo Youn Chung, Yhun Yhong Sheen, Dong Chuol Moon, Yeun Sook Song, Kyong Soon Kim, Sukgil Song, Yeo Pyo Yun, Myung Koo Lee, Ki Wan Oh, Do Young Yoon, and Jin Tae Hong

Peroxisome Proliferator-Activated Receptor- Activator 15-Deoxy-^12,14-Prostaglandin J₂ Inhibits Neuroblastoma Cell Growth through Induction of Apoptosis: Association with Extracellular Signal-Regulated Kinase Signal Pathway
J Pharmacol Exp Ther 2003 307: 505-517. Published online September 9, 2003; 10.1124/jpet.103.053876 [Abstract] [Full Text] [PDF]  

Petrus J. Pauwels and Francis C. Colpaert

Ca²⁺ Responses in Chinese Hamster Ovary-K1 Cells Demonstrate an Atypical Pattern of Ligand-Induced 5-HT_1A Receptor Activation
J Pharmacol Exp Ther 2003 307: 608-614. Published online September 11, 2003; 10.1124/jpet.103.055871 [Abstract] [Full Text] [PDF]  

Robert E. Carraway, Xianyong Gui, and David E. Cochrane

Ca²⁺ Channel Blockers Enhance Neurotensin (NT) Binding and Inhibit NT-Induced Inositol Phosphate Formation in Prostate Cancer PC3 Cells
J Pharmacol Exp Ther 2003 307: 640-650. Published online September 9, 2003; 10.1124/jpet.103.052688 [Abstract] [Full Text] [PDF] Correction  

Tim D. Werry, Graeme F. Wilkinson, and Gary B. Willars

Cross Talk between P2Y₂ Nucleotide Receptors and CXC Chemokine Receptor 2 Resulting in Enhanced Ca²⁺ Signaling Involves Enhancement of Phospholipase C Activity and Is Enabled by Incremental Ca²⁺ Release in Human Embryonic Kidney Cells
J Pharmacol Exp Ther 2003 307: 661-669. Published online September 15, 2003; 10.1124/jpet.103.055632 [Abstract] [Full Text] [PDF]  

Erding Hu, Edward Dul, Chiu-Mei Sung, Zunxuan Chen, Robert Kirkpatrick, Gui-Feng Zhang, Kyung Johanson, Ronggang Liu, Amparo Lago, Glenn Hofmann, Ricardo Macarron, Maite De Los Frailes, Paloma Perez, John Krawiec, James Winkler, and Michael Jaye

Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
J Pharmacol Exp Ther 2003 307: 720-728. Published online September 15, 2003; 10.1124/jpet.103.055541 [Abstract] [Full Text] [PDF]  

Limen Chi and Maarten E. A. Reith

Substrate-Induced Trafficking of the Dopamine Transporter in Heterologously Expressing Cells and in Rat Striatal Synaptosomal Preparations
J Pharmacol Exp Ther 2003 307: 729-736. Published online September 15, 2003; 10.1124/jpet.103.055095 [Abstract] [Full Text] [PDF]  

Isabelle Passagne, Alexandre Evrard, Jean-Yves Winum, Philippe Depeille, Pierre Cuq, Jean-Louis Montero, Didier Cupissol, and Laurence Vian

Cytotoxicity, DNA Damage, and Apoptosis Induced by New Fotemustine Analogs on Human Melanoma Cells in Relation to O⁶-Methylguanine DNA-Methyltransferase Expression
J Pharmacol Exp Ther 2003 307: 816-823. Published online September 11, 2003; 10.1124/jpet.103.051938 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Tom Stover and Mark Kester

Liposomal Delivery Enhances Short-Chain Ceramide-Induced Apoptosis of Breast Cancer Cells
J Pharmacol Exp Ther 2003 307: 468-475. Published online September 15, 2003; 10.1124/jpet.103.054056 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Christian Thorkildsen, Søren Neve, Bjarne Due Larsen, Eddi Meier, and Jørgen Søberg Petersen

Glucagon-Like Peptide 1 Receptor Agonist ZP10A Increases Insulin mRNA Expression and Prevents Diabetic Progression in db/db Mice
J Pharmacol Exp Ther 2003 307: 490-496. Published online September 15, 2003; 10.1124/jpet.103.051987 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Xiaonan Han, Takashi Uchiyama, Penny L. Sappington, Arino Yaguchi, Runkuan Yang, Mitchell P. Fink, and Russell L. Delude

NAD⁺ Ameliorates Inflammation-Induced Epithelial Barrier Dysfunction in Cultured Enterocytes and Mouse Ileal Mucosa
J Pharmacol Exp Ther 2003 307: 443-449. Published online September 15, 2003; 10.1124/jpet.103.056556 [Abstract] [Full Text] [PDF]  

John R. Grider

Neurotransmitters Mediating the Intestinal Peristaltic Reflex in the Mouse
J Pharmacol Exp Ther 2003 307: 460-467. Published online September 9, 2003; 10.1124/jpet.103.053512 [Abstract] [Full Text] [PDF]  

Michael Schumann, Tomoo Nakagawa, Samuel A. Mantey, Kenji Tokita, David J. Venzon, Simon J. Hocart, Richard V. Benya, and Robert T. Jensen

Importance of Amino Acids of the Central Portion of the Second Intracellular Loop of the Gastrin-Releasing Peptide Receptor for Phospholipase C Activation, Internalization, and Chronic Down-Regulation
J Pharmacol Exp Ther 2003 307: 597-607. Published online September 11, 2003; 10.1124/jpet.103.055087 [Abstract] [Full Text] [PDF]  

Jiing C. Luo, Vivian Y. Shin, Edgar S. L. Liu, Wallace H. L. So, Yi N. Ye, Full Y. Chang, and Chi H. Cho

Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats
J Pharmacol Exp Ther 2003 307: 692-698. Published online September 9, 2003; 10.1124/jpet.103.055202 [Abstract] [Full Text] [PDF]  

Masanori Takeeda, Masanori Yamato, Shinichi Kato, and Koji Takeuchi

Cyclooxygenase Isozymes Involved in Adaptive Functional Responses in Rat Stomach after Barrier Disruption
J Pharmacol Exp Ther 2003 307: 713-719. Published online September 15, 2003; 10.1124/jpet.103.054973 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Michitaka Shichijo, Hiromi Sugimoto, Koichi Nagao, Hisayo Inbe, Jeffrey A. Encinas, Keisuke Takeshita, Kevin B. Bacon, and Florian Gantner

Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-keto-prostaglandin D₂-Induced Eosinophilia in Rats
J Pharmacol Exp Ther 2003 307: 518-525. Published online September 15, 2003; 10.1124/jpet.103.055442 [Abstract] [Full Text] [PDF]  

Mitsuteru Ishiwara, Yasuo Aoki, Hidetsugu Takagaki, Michio Ui, and Fumikazu Okajima

TA-270 [4-Hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an Anti-Asthmatic Agent, Inhibits Leukotriene Production Induced by IgE Receptor Stimulation in RBL-2H3 Cells
J Pharmacol Exp Ther 2003 307: 583-588. Published online September 11, 2003; 10.1124/jpet.103.055145 [Abstract] [Full Text] [PDF]  

Chantal Beumer, Marty Wulferink, Willem Raaben, Daniëlle Fiechter, Ruud Brands, and Willem Seinen

Calf Intestinal Alkaline Phosphatase, a Novel Therapeutic Drug for Lipopolysaccharide (LPS)-Mediated Diseases, Attenuates LPS Toxicity in Mice and Piglets
J Pharmacol Exp Ther 2003 307: 737-744. Published online September 11, 2003; 10.1124/jpet.103.056606 [Abstract] [Full Text] [PDF]  

Norma C. Alonzo and Barbara M. Bayer

Antagonism of N-Methyl-D-aspartate Receptors Reduces the Vulnerability of the Immune System to Stress after Chronic Morphine
J Pharmacol Exp Ther 2003 307: 793-800. Published online September 9, 2003; 10.1124/jpet.103.053264 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Eric Backes and Scott E. Hemby

Discrete Cell Gene Profiling of Ventral Tegmental Dopamine Neurons after Acute and Chronic Cocaine Self-Administration
J Pharmacol Exp Ther 2003 307: 450-459. Published online September 9, 2003; 10.1124/jpet.103.054965 [Abstract] [Full Text] [PDF]  

M. I. Damaj, W. Kao, and B. R. Martin

Characterization of Spontaneous and Precipitated Nicotine Withdrawal in the Mouse
J Pharmacol Exp Ther 2003 307: 526-534. Published online September 11, 2003; 10.1124/jpet.103.054908 [Abstract] [Full Text] [PDF]  

Min Wu, Samuel S. Newton, Joshua B. Atkins, Changqing Xu, Ronald S. Duman, and Meenakshi Alreja

Acetylcholinesterase Inhibitors Activate Septohippocampal GABAergic Neurons via Muscarinic but Not Nicotinic Receptors
J Pharmacol Exp Ther 2003 307: 535-543. Published online September 9, 2003; 10.1124/jpet.103.052514 [Abstract] [Full Text] [PDF]  

Adam W. Hendricson, Mark P. Thomas, Melanie J. Lippmann, and Richard A. Morrisett

Suppression of L-Type Voltage-Gated Calcium Channel-Dependent Synaptic Plasticity by Ethanol: Analysis of Miniature Synaptic Currents and Dendritic Calcium Transients
J Pharmacol Exp Ther 2003 307: 550-558. Published online September 11, 2003; 10.1124/jpet.103.055137 [Abstract] [Full Text] [PDF]  

D. A. Drakulich, A. M. Walls, M. L. Toews, and T. D. Hexum

Neuropeptide Y Receptor-Mediated Sensitization of ATP-Stimulated Inositol Phosphate Formation
J Pharmacol Exp Ther 2003 307: 559-565. Published online September 11, 2003; 10.1124/jpet.103.053082 [Abstract] [Full Text] [PDF]  

Roh-Yu Shen

Ethanol Withdrawal Reduces the Number of Spontaneously Active Ventral Tegmental Area Dopamine Neurons in Conscious Animals
J Pharmacol Exp Ther 2003 307: 566-572. Published online September 9, 2003; 10.1124/jpet.103.053371 [Abstract] [Full Text] [PDF]  

Xinyu D. Li and Jerry J. Buccafusco

Effect of -Amyloid Peptide 1-42 on the Cytoprotective Action Mediated by 7 Nicotinic Acetylcholine Receptors in Growth Factor-Deprived Differentiated PC-12 Cells
J Pharmacol Exp Ther 2003 307: 670-675. Published online September 11, 2003; 10.1124/jpet.103.053785 [Abstract] [Full Text] [PDF]  

Shao-Rui Chen and Hui-Lin Pan

Up-Regulation of Spinal Muscarinic Receptors and Increased Antinociceptive Effect of Intrathecal Muscarine in Diabetic Rats
J Pharmacol Exp Ther 2003 307: 676-681. Published online September 9, 2003; 10.1124/jpet.103.055905 [Abstract] [Full Text] [PDF]  

Ronald J. Tallarida, Alan Cowan, and Robert B. Raffa

Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice
J Pharmacol Exp Ther 2003 307: 699-704. Published online September 9, 2003; 10.1124/jpet.103.054320 [Abstract] [Full Text] [PDF]  

F. P. Monnet, M. P. Morin-Surun, J. Leger, and L. Combettes

Protein Kinase C-Dependent Potentiation of Intracellular Calcium Influx by ₁ Receptor Agonists in Rat Hippocampal Neurons
J Pharmacol Exp Ther 2003 307: 705-712. Published online September 15, 2003; 10.1124/jpet.103.053447 [Abstract] [Full Text] [PDF]  

S. A. G. Visser, D. R. H. Huntjens, P. H. van der Graaf, L. A. Peletier, and M. Danhof

Mechanism-Based Modeling of the Pharmacodynamic Interaction of Alphaxalone and Midazolam in Rats
J Pharmacol Exp Ther 2003 307: 765-775. Published online September 15, 2003; 10.1124/jpet.103.054510 [Abstract] [Full Text] [PDF]  

Glória Queiroz, Carlos Talaia, and Jorge Gonçalves

ATP Modulates Noradrenaline Release by Activation of Inhibitory P2Y Receptors and Facilitatory P2X Receptors in the Rat Vas Deferens
J Pharmacol Exp Ther 2003 307: 809-815. Published online September 9, 2003; 10.1124/jpet.103.054809 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Letizia Antonilli, Carmen Suriano, Giovanna Paolone, Aldo Badiani, and Paolo Nencini

Repeated Exposures to Heroin and/or Cadmium Alter the Rate of Formation of Morphine Glucuronides in the Rat
J Pharmacol Exp Ther 2003 307: 651-660. Published online September 15, 2003; 10.1124/jpet.103.055467 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect"
J Pharmacol Exp Ther 2003 307: 829. [Full Text] [PDF]  

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