PERSPECTIVES IN PHARMACOLOGY:

Robert A. Roth, James P. Luyendyk, Jane F. Maddox, and Patricia E. Ganey

Inflammation and Drug Idiosyncrasy—Is There a Connection?
J Pharmacol Exp Ther 2003 307: 1-8. Published online September 3, 2003; 10.1124/jpet.102.041624 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Lyne Villeneuve, Hugo Girard, Louis-Charles Fortier, Jean-Francois Gagné, and Chantal Guillemette

Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10-hydroxycamptothecin and Flavopiridol Anticancer Drugs
J Pharmacol Exp Ther 2003 307: 117-128. Published online August 27, 2003; 10.1124/jpet.103.054072 [Abstract] [Full Text] [PDF]  

Shannon Dallas, Xiaoping Zhu, Sylvain Baruchel, Lyanne Schlichter, and Reina Bendayan

Functional Expression of the Multidrug Resistance Protein 1 in Microglia
J Pharmacol Exp Ther 2003 307: 282-290. Published online July 31, 2003; 10.1124/jpet.103.054304 [Abstract] [Full Text] [PDF]  

Ming Hu, June Chen, and Huimin Lin

Metabolism of Flavonoids via Enteric Recycling: Mechanistic Studies of Disposition of Apigenin in the Caco-2 Cell Culture Model
J Pharmacol Exp Ther 2003 307: 314-321. Published online July 31, 2003; 10.1124/jpet.103.053496 [Abstract] [Full Text] [PDF]  

Elizabeth K. Johnsrud, Sevasti B. Koukouritaki, Karthika Divakaran, Laura L. Brunengraber, Ronald N. Hines, and D. Gail McCarver

Human Hepatic CYP2E1 Expression during Development
J Pharmacol Exp Ther 2003 307: 402-407. Published online September 3, 2003; 10.1124/jpet.103.053124 [Abstract] [Full Text] [PDF] Correction  

BEHAVIORAL PHARMACOLOGY:

Andrew C. Barrett, Eric S. Smith, and Mitchell J. Picker

Capsaicin-Induced Hyperalgesia and µ-Opioid-Induced Antihyperalgesia in Male and Female Fischer 344 Rats
J Pharmacol Exp Ther 2003 307: 237-245. Published online September 3, 2003; 10.1124/jpet.103.054478 [Abstract] [Full Text] [PDF]  

Jack H. Mendelson, Michelle B. Sholar, Nicole H. Mutschler, Maria Jaszyna-Gasior, Nathalie V. Goletiani, Arthur J. Siegel, and Nancy K. Mello

Effects of Intravenous Cocaine and Cigarette Smoking on Luteinizing Hormone, Testosterone, and Prolactin in Men
J Pharmacol Exp Ther 2003 307: 339-348. Published online July 31, 2003; 10.1124/jpet.103.052928 [Abstract] [Full Text] [PDF]  

Joshua A. Lile, Zhixia Wang, William L. Woolverton, Jessica E. France, Timothy C. Gregg, Huw M. L. Davies, and Michael A. Nader

The Reinforcing Efficacy of Psychostimulants in Rhesus Monkeys: The Role of Pharmacokinetics and Pharmacodynamics
J Pharmacol Exp Ther 2003 307: 356-366. Published online September 3, 2003; 10.1124/jpet.103.049825 [Abstract] [Full Text] [PDF]  

Stuart O. Isaac and Craig W. Berridge

Wake-Promoting Actions of Dopamine D1 and D2 Receptor Stimulation
J Pharmacol Exp Ther 2003 307: 386-394. Published online August 27, 2003; 10.1124/jpet.103.053918 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Jacicarlos L. Alencar, Irina Lobysheva, Karel Chalupsky, Michel Geffard, Françoise Nepveu, Jean-Claude Stoclet, and Bernard Muller

S-Nitrosating Nitric Oxide Donors Induce Long-Lasting Inhibition of Contraction in Isolated Arteries
J Pharmacol Exp Ther 2003 307: 152-159. Published online September 3, 2003; 10.1124/jpet.103.052605 [Abstract] [Full Text] [PDF]  

Robert Létienne, Yvan Verscheure, and Gareth W. John

Investigation of the Effects of Naratriptan, Rizatriptan, and Sumatriptan on Jugular Venous Oxygen Saturation in Anesthetized Pigs: Implications for Their Mechanism of Acute Antimigraine Action
J Pharmacol Exp Ther 2003 307: 168-174. Published online September 3, 2003; 10.1124/jpet.103.054940 [Abstract] [Full Text] [PDF]  

Naoyuki Matsuda, Yuichi Hattori, Xiao-Hong Zhang, Hiroyuki Fukui, Osamu Kemmotsu, and Satoshi Gando

Contractions to Histamine in Pulmonary and Mesenteric Arteries from Endotoxemic Rabbits: Modulation by Vascular Expressions of Inducible Nitric-Oxide Synthase and Histamine H₁-Receptors
J Pharmacol Exp Ther 2003 307: 175-181. Published online September 3, 2003; 10.1124/jpet.103.054163 [Abstract] [Full Text] [PDF]  

Gong Zhao, Axel Linke, Xiaobin Xu, Manuel Ochoa, Francis Belloni, Luiz Belardinelli, and Thomas H. Hintze

Comparative Profile of Vasodilation by CVT-3146, a Novel A_2A Receptor Agonist, and Adenosine in Conscious Dogs
J Pharmacol Exp Ther 2003 307: 182-189. Published online September 3, 2003; 10.1124/jpet.103.053306 [Abstract] [Full Text] [PDF]  

J. Quilley, Y. Qiu, and J. Hirt

Inhibitors of 20-Hydroxyeicosatetraenoic Acid Reduce Renal Vasoconstrictor Responsiveness
J Pharmacol Exp Ther 2003 307: 223-229. Published online September 3, 2003; 10.1124/jpet.103.051995 [Abstract] [Full Text] [PDF]  

Erin A. Booth, Marta Marchesi, Edward J. Kilbourne, and Benedict R. Lucchesi

17-Estradiol as a Receptor-Mediated Cardioprotective Agent
J Pharmacol Exp Ther 2003 307: 395-401. Published online July 31, 2003; 10.1124/jpet.103.054205 [Abstract] [Full Text] [PDF]  

Stuart R. Ruch, Manabu Nishio, and J Andrew Wasserstrom

Effect of Cardiac Glycosides on Action Potential Characteristics and Contractility in Cat Ventricular Myocytes: Role of Calcium Overload
J Pharmacol Exp Ther 2003 307: 419-428. Published online September 3, 2003; 10.1124/jpet.103.049189 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Aina Westrheim Ravna, Ingebrigt Sylte, and Svein G. Dahl

Molecular Mechanism of Citalopram and Cocaine Interactions with Neurotransmitter Transporters
J Pharmacol Exp Ther 2003 307: 34-41. Published online August 27, 2003; 10.1124/jpet.103.054593 [Abstract] [Full Text] [PDF]  

A. Banan, J. Z. Fields, L. J. Zhang, M. Shaikh, A. Farhadi, and A. Keshavarzian

Isoform of Protein Kinase C Prevents Oxidant-Induced Nuclear Factor-B Activation and I-B Degradation: A Fundamental Mechanism for Epidermal Growth Factor Protection of the Microtubule Cytoskeleton and Intestinal Barrier Integrity
J Pharmacol Exp Ther 2003 307: 53-66. Published online July 31, 2003; 10.1124/jpet.103.053835 [Abstract] [Full Text] [PDF]  

Satoru Koyano, Yoshiro Saito, Michiyo Nagano, Keiko Maekawa, Yutaka Kikuchi, Norie Murayama, Tomofumi Fujino, Shogo Ozawa, Toshiharu Nakajima, Kenji Matsumoto, Hirohisa Saito, and Jun-Ichi Sawada

Functional Analysis of Three Genetic Polymorphisms in the Glucocorticoid Receptor Gene
J Pharmacol Exp Ther 2003 307: 110-116. Published online September 3, 2003; 10.1124/jpet.103.054155 [Abstract] [Full Text] [PDF]  

Wakako Hamabe, Ryousuke Fujita, and Hiroshi Ueda

Neuronal Necrosis Inhibition by Insulin through Protein Kinase C Activation
J Pharmacol Exp Ther 2003 307: 205-212. Published online June 13, 2003; 10.1124/jpet.103.053033 [Abstract] [Full Text] [PDF]  

Kazuhiko Takahashi, Shigeru Tokita, and Hidehito Kotani

Generation and Characterization of Highly Constitutive Active Histamine H3 Receptors
J Pharmacol Exp Ther 2003 307: 213-218. Published online September 3, 2003; 10.1124/jpet.103.053249 [Abstract] [Full Text] [PDF]  

Tetsuya Yamamoto, Stephen Hsu, Jill Lewis, John Wataha, Douglas Dickinson, Baldev Singh, Wendy B. Bollag, Petra Lockwood, Eisaku Ueta, Tokio Osaki, and George Schuster

Green Tea Polyphenol Causes Differential Oxidative Environments in Tumor versus Normal Epithelial Cells
J Pharmacol Exp Ther 2003 307: 230-236. Published online September 3, 2003; 10.1124/jpet.103.054676 [Abstract] [Full Text] [PDF]  

Kelli S. Bramlett, Keith A. Houck, Kristen M. Borchert, Michele S. Dowless, Palaniappan Kulanthaivel, Youyan Zhang, Thomas P. Beyer, Robert Schmidt, Jeffrey S. Thomas, Laura F. Michael, Robert Barr, Chahrzad Montrose, Patrick I. Eacho, Guoqing Cao, and Thomas P. Burris

A Natural Product Ligand of the Oxysterol Receptor, Liver X Receptor
J Pharmacol Exp Ther 2003 307: 291-296. Published online July 31, 2003; 10.1124/jpet.103.052852 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Hong Zhang, Jennifer Taylor, Doreen Luther, Joe Johnston, Susan Murray, Jacqueline R. Wyatt, Andrew T. Watt, Seongjoon Koo, Cathie York-DeFalco, Kimberly Stecker, and Nicholas M. Dean

Antisense Oligonucleotide Inhibition of Bcl-xL and Bid Expression in Liver Regulates Responses in a Mouse Model of Fas-Induced Fulminant Hepatitis
J Pharmacol Exp Ther 2003 307: 24-33. Published online July 31, 2003; 10.1124/jpet.103.050435 [Abstract] [Full Text] [PDF]  

Hiroshi Kono, Masami Asakawa, Hideki Fujii, Akira Maki, Hidetake Amemiya, Masayuki Yamamoto, Masanori Matsuda, and Yoshiro Matsumoto

Edaravone, a Novel Free Radical Scavenger, Prevents Liver Injury and Mortality in Rats Administered Endotoxin
J Pharmacol Exp Ther 2003 307: 74-82. Published online September 3, 2003; 10.1124/jpet.103.053595 [Abstract] [Full Text] [PDF]  

Yoshihiro Tahara, Akio Ido, Shojiro Yamamoto, Yoshifumi Miyata, Hirofumi Uto, Takeshi Hori, Katsuhiro Hayashi, and Hirohito Tsubouchi

Hepatocyte Growth Factor Facilitates Colonic Mucosal Repair in Experimental Ulcerative Colitis in Rats
J Pharmacol Exp Ther 2003 307: 146-151. Published online September 3, 2003; 10.1124/jpet.103.054106 [Abstract] [Full Text] [PDF]  

Aldo D. Mottino, Luis M. Veggi, Marcie Wood, Joyce M. Vélez Román, and Mary Vore

Biliary Secretion of Glutathione in Estradiol 17-D-Glucuronide-Induced Cholestasis
J Pharmacol Exp Ther 2003 307: 306-313. Published online July 31, 2003; 10.1124/jpet.103.054544 [Abstract] [Full Text] [PDF]  

Kazuharu Furutani, Takeshi Aihara, Eiji Nakamura, Satoshi Tanaka, Atsushi Ichikawa, Hiroshi Ohtsu, and Susumu Okabe

Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice
J Pharmacol Exp Ther 2003 307: 331-338. Published online July 31, 2003; 10.1124/jpet.103.052019 [Abstract] [Full Text] [PDF]  

Ewa Sundström, Lena Låstbom, Åke Ryrfeldt, and Sven-Erik Dahlén

Interactions among Three Classes of Mediators Explain Antigen-Induced Bronchoconstriction in the Isolated Perfused and Ventilated Guinea Pig Lung
J Pharmacol Exp Ther 2003 307: 408-418. Published online September 3, 2003; 10.1124/jpet.103.053546 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Tamaki Yamada, Atsushi Kuno, Kazuhiko Masuda, Kumiko Ogawa, Mitsue Sogawa, Soichi Nakamura, Tomoaki Ando, Hitoshi Sano, Takahiro Nakazawa, Hirotaka Ohara, Tomoyuki Nomura, Takashi Joh, and Makoto Itoh

Candesartan, an Angiotensin II Receptor Antagonist, Suppresses Pancreatic Inflammation and Fibrosis in Rats
J Pharmacol Exp Ther 2003 307: 17-23. Published online August 27, 2003; 10.1124/jpet.103.053322 [Abstract] [Full Text] [PDF]  

István Kurucz, Szilveszter Tóth, Klára Németh, Katalin Török, Viola Csillik-Perczel, Ágnes Pataki, Cecilia Salamon, Zoltán Nagy, József I. Székely, Katalin Horváth, and Nicholas Bodor

Potency and Specificity of the Pharmacological Action of a New, Antiasthmatic, Topically Administered Soft Steroid, Etiprednol Dicloacetate (BNP-166)
J Pharmacol Exp Ther 2003 307: 83-92. Published online July 31, 2003; 10.1124/jpet.103.053652 [Abstract] [Full Text] [PDF]  

Jin Y. Jin, Richard R. Almon, Debra C. DuBois, and William J. Jusko

Modeling of Corticosteroid Pharmacogenomics in Rat Liver Using Gene Microarrays
J Pharmacol Exp Ther 2003 307: 93-109. Published online June 13, 2003; 10.1124/jpet.103.053256 [Abstract] [Full Text] [PDF]  

Elisa Tedeschi, Marta Menegazzi, Daniela Margotto, Hisanori Suzuki, Ulrich Förstermann, and Hartmut Kleinert

Anti-Inflammatory Actions of St. John's Wort: Inhibition of Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1 (STAT-1) Activation
J Pharmacol Exp Ther 2003 307: 254-261. Published online September 3, 2003; 10.1124/jpet.103.054460 [Abstract] [Full Text] [PDF]  

Guillermo Pérez de Lema, Cor de Wit, Clemens D. Cohen, Elena Nieto, Ana Molina, Bernhard Banas, Bruno Luckow, Ana B. Vicente, Francisco Mampaso, and Detlef Schlöndorff

Angiotensin Inhibition Reduces Glomerular Damage and Renal Chemokine Expression in MRL/lpr Mice
J Pharmacol Exp Ther 2003 307: 275-281. Published online September 3, 2003; 10.1124/jpet.103.053678 [Abstract] [Full Text] [PDF]  

Rakesh K. Kumar, Cristan Herbert, Paul S. Thomas, Lutz Wollin, Rolf Beume, Ming Yang, Dianne C. Webb, and Paul S. Foster

Inhibition of Inflammation and Remodeling by Roflumilast and Dexamethasone in Murine Chronic Asthma
J Pharmacol Exp Ther 2003 307: 349-355. Published online September 3, 2003; 10.1124/jpet.103.053819 [Abstract] [Full Text] [PDF]  

H. Kuss, N. Hoefgen, S. Johanssen, T. Kronbach, and C. Rundfeldt

In Vivo Efficacy in Airway Disease Models of N-(3,5-Dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic Acid Amide (AWD 12-281), a Selective Phosphodiesterase 4 Inhibitor for Inhaled Administration
J Pharmacol Exp Ther 2003 307: 373-385. Published online August 27, 2003; 10.1124/jpet.103.053942 [Abstract] [Full Text] [PDF]  

Marcelo Marcet-Palacios, Kathryn Graham, Carol Cass, A. Dean Befus, Irvin Mayers, and Marek W. Radomski

Nitric Oxide and Cyclic GMP Increase the Expression of Matrix Metalloproteinase-9 in Vascular Smooth Muscle
J Pharmacol Exp Ther 2003 307: 429-436. Published online September 3, 2003; 10.1124/jpet.103.050385 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Cecilia M. Borghese, L. Ashley Henderson, Virginia Bleck, James R. Trudell, and R. Adron Harris

Sites of Excitatory and Inhibitory Actions of Alcohols on Neuronal 24 Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 2003 307: 42-52. Published online September 3, 2003; 10.1124/jpet.103.053710 [Abstract] [Full Text] [PDF] Correction  

Melisa J. Wallace, Robert E. Blair, Katherine W. Falenski, Billy R. Martin, and Robert J. DeLorenzo

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
J Pharmacol Exp Ther 2003 307: 129-137. Published online September 3, 2003; 10.1124/jpet.103.051920 [Abstract] [Full Text] [PDF]  

Richard B. Rothman, Nga Vu, John S. Partilla, Bryan L. Roth, Sandra J. Hufeisen, Beth A. Compton-Toth, Jon Birkes, Richard Young, and Richard A. Glennon

In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates
J Pharmacol Exp Ther 2003 307: 138-145. Published online September 3, 2003; 10.1124/jpet.103.053975 [Abstract] [Full Text] [PDF]  

Shigeki Moriguchi, William Marszalec, Xilong Zhao, Jay Z. Yeh, and Toshio Narahashi

Potentiation of N-Methyl-D-aspartate-Induced Currents by the Nootropic Drug Nefiracetam in Rat Cortical Neurons
J Pharmacol Exp Ther 2003 307: 160-167. Published online June 12, 2003; 10.1124/jpet.103.050823 [Abstract] [Full Text] [PDF]  

Jian Mu, W. Breckinridge Carden, Nuwan C. Kurukulasuriya, Georgia M. Alexander, and Dwayne W. Godwin

Ethanol Influences on Native T-Type Calcium Current in Thalamic Sleep Circuitry
J Pharmacol Exp Ther 2003 307: 197-204. Published online July 31, 2003; 10.1124/jpet.103.053272 [Abstract] [Full Text] [PDF]  

Khalid Benamar, Menachem Z. Yondorf, David Kon, Ellen B. Geller, and Martin W. Adler

Role of the Nitric-Oxide Synthase Isoforms during Morphine-Induced Hyperthermia in Rats
J Pharmacol Exp Ther 2003 307: 219-222. Published online September 3, 2003; 10.1124/jpet.103.053181 [Abstract] [Full Text] [PDF]  

Yu Zhao, Han-Ting Zhang, and James M. O'Donnell

Antidepressant-Induced Increase in High-Affinity Rolipram Binding Sites in Rat Brain: Dependence on Noradrenergic and Serotonergic Function
J Pharmacol Exp Ther 2003 307: 246-253. Published online September 3, 2003; 10.1124/jpet.103.053215 [Abstract] [Full Text] [PDF]  

Johanna Weiss, Christian Johannes Kerpen, Heike Lindenmaier, Sven-Maria Gregor Dormann, and Walter Emil Haefeli

Interaction of Antiepileptic Drugs with Human P-Glycoprotein in Vitro
J Pharmacol Exp Ther 2003 307: 262-267. Published online September 3, 2003; 10.1124/jpet.103.054197 [Abstract] [Full Text] [PDF]  

F. Marchand, D. Ardid, E. Chapuy, A. Alloui, D. Jourdan, and A. Eschalier

Evidence for an Involvement of Supraspinal - and Spinal µ-Opioid Receptors in the Antihyperalgesic Effect of Chronically Administered Clomipramine in Mononeuropathic Rats
J Pharmacol Exp Ther 2003 307: 268-274. Published online September 3, 2003; 10.1124/jpet.103.052613 [Abstract] [Full Text] [PDF]  

Julie C. Lauterborn, Giang S. Truong, Michel Baudry, Xiaoning Bi, Gary Lynch, and Christine M. Gall

Chronic Elevation of Brain-Derived Neurotrophic Factor by Ampakines
J Pharmacol Exp Ther 2003 307: 297-305. Published online July 31, 2003; 10.1124/jpet.103.053694 [Abstract] [Full Text] [PDF]  

Stephan Urwyler, Mario F. Pozza, Kurt Lingenhoehl, Johannes Mosbacher, Christina Lampert, Wolfgang Froestl, Manuel Koller, and Klemens Kaupmann

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and Structurally Related Compounds: Novel Allosteric Enhancers of -Aminobutyric Acid_B Receptor Function
J Pharmacol Exp Ther 2003 307: 322-330. Published online September 3, 2003; 10.1124/jpet.103.053074 [Abstract] [Full Text] [PDF]  

S. K. Joshi, Kenneth Lamb, K. Bielefeldt, and G. F. Gebhart

Arylacetamide -Opioid Receptor Agonists Produce a Tonic- and Use-Dependent Block of Tetrodotoxin-Sensitive and -Resistant Sodium Currents in Colon Sensory Neurons
J Pharmacol Exp Ther 2003 307: 367-372. Published online September 3, 2003; 10.1124/jpet.103.052829 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

James P. Luyendyk, Jane F. Maddox, Gregory N. Cosma, Patricia E. Ganey, Gary L. Cockerell, and Robert A. Roth

Ranitidine Treatment during a Modest Inflammatory Response Precipitates Idiosyncrasy-Like Liver Injury in Rats
J Pharmacol Exp Ther 2003 307: 9-16. Published online July 31, 2003; 10.1124/jpet.103.054288 [Abstract] [Full Text] [PDF]  

Mary Lynn Bajt, Tamara R. Knight, Anwar Farhood, and Hartmut Jaeschke

Scavenging Peroxynitrite with Glutathione Promotes Regeneration and Enhances Survival during Acetaminophen-Induced Liver Injury in Mice
J Pharmacol Exp Ther 2003 307: 67-73. Published online September 3, 2003; 10.1124/jpet.103.052506 [Abstract] [Full Text] [PDF]  

P. I. Hammond, C. Kern, F. Hong, T. M. Kollmeyer, Y.-P. Pang, and S. Brimijoin

Cholinesterase Reactivation in Vivo with a Novel Bis-Oxime Optimized by Computer-Aided Design
J Pharmacol Exp Ther 2003 307: 190-196. Published online July 31, 2003; 10.1124/jpet.103.053405 [Abstract] [Full Text] [PDF]  

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