PERSPECTIVES IN PHARMACOLOGY:

A. V. Terry, Jr and J. J. Buccafusco

The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development
J Pharmacol Exp Ther 2003 306: 821-827. Published online June 12, 2003; 10.1124/jpet.102.041616 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

David M. Shackleford, W. A. Faassen, Natalie Houwing, Holger Lass, Glenn A. Edwards, Christopher J. H. Porter, and William N. Charman

Contribution of Lymphatically Transported Testosterone Undecanoate to the Systemic Exposure of Testosterone after Oral Administration of Two Andriol Formulations in Conscious Lymph Duct-Cannulated Dogs
J Pharmacol Exp Ther 2003 306: 925-933. Published online June 13, 2003; 10.1124/jpet.103.052522 [Abstract] [Full Text] [PDF]  

Naoko Nonaka, Seiji Shioda, Michael L. Niehoff, and William A. Banks

Characterization of Blood-Brain Barrier Permeability to PYY_3-36 in the Mouse
J Pharmacol Exp Ther 2003 306: 948-953. Published online May 15, 2003; 10.1124/jpet.103.051821 [Abstract] [Full Text] [PDF]  

Jasminder Sahi, Mark A. Milad, Xianxian Zheng, Kelly A. Rose, Hongbing Wang, Linda Stilgenbauer, Darryl Gilbert, Summer Jolley, Ralph H. Stern, and Edward L. LeCluyse

Avasimibe Induces CYP3A4 and Multiple Drug Resistance Protein 1 Gene Expression through Activation of the Pregnane X Receptor
J Pharmacol Exp Ther 2003 306: 1027-1034. Published online May 23, 2003; 10.1124/jpet.103.050526 [Abstract] [Full Text] [PDF]  

Gregory J. R. Charrois and Theresa M. Allen

Multiple Injections of Pegylated Liposomal Doxorubicin: Pharmacokinetics and Therapeutic Activity
J Pharmacol Exp Ther 2003 306: 1058-1067. Published online June 13, 2003; 10.1124/jpet.103.053413 [Abstract] [Full Text] [PDF]  

Sujal V. Deshmukh, Tatiana N. Nanovskaya, and Mahmoud S. Ahmed

Aromatase Is the Major Enzyme Metabolizing Buprenorphine in Human Placenta
J Pharmacol Exp Ther 2003 306: 1099-1105. Published online June 13, 2003; 10.1124/jpet.103.053199 [Abstract] [Full Text] [PDF]  

Ronald N. Hines, Zhaohui Luo, Kathleen A. Hopp, Erwin T. Cabacungan, Sevasti B. Koukouritaki, and D. Gail McCarver

Genetic Variability at the Human FMO1 Locus: Significance of a Basal Promoter Yin Yang 1 Element Polymorphism (FMO1^*6)
J Pharmacol Exp Ther 2003 306: 1210-1218. Published online June 26, 2003; 10.1124/jpet.103.053686 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Eduardo R. Butelman, Jonathan W. Ball, Todd J. Harris, and Mary Jeanne Kreek

Topical Capsaicin-Induced Allodynia in Unanesthetized Primates: Pharmacological Modulation
J Pharmacol Exp Ther 2003 306: 1106-1114. Published online June 26, 2003; 10.1124/jpet.103.052381 [Abstract] [Full Text] [PDF]  

Marco Aurelio de Paula Brotto

Temporal Effects of Stress by Immobilization and Sensitivity of the Isolated Rat Pacemaker to Isoproterenol: Roles of Corticosterone, Neuronal Uptake, and -Adrenergic Homogeneity
J Pharmacol Exp Ther 2003 306: 1152-1158. Published online June 26, 2003; 10.1124/jpet.103.052670 [Abstract] [Full Text] [PDF]  

Peter Dobelis, Scott Hutton, Ying Lu, and Allan C. Collins

GABAergic Systems Modulate Nicotinic Receptor-Mediated Seizures in Mice
J Pharmacol Exp Ther 2003 306: 1159-1166. Published online June 26, 2003; 10.1124/jpet.103.053066 [Abstract] [Full Text] [PDF]  

Stacy L. Sell, Lance R. McMahon, and Charles P. France

Relative Efficacy of Buprenorphine, Nalbuphine and Morphine in Opioid-Treated Rhesus Monkeys Discriminating Naltrexone
J Pharmacol Exp Ther 2003 306: 1167-1173. Published online May 23, 2003; 10.1124/jpet.103.051425 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Nathalie Leducq, Françoise Bono, Thierry Sulpice, Val érie Vin, Philip Janiak, Gérard Le Fur, Steve E. O'Connor, and Jean-Marc Herbert

Role of Peripheral Benzodiazepine Receptors in Mitochondrial, Cellular, and Cardiac Damage Induced by Oxidative Stress and Ischemia-Reperfusion
J Pharmacol Exp Ther 2003 306: 828-837. Published online September 1, 2003; 10.1124/jpet.103.052068 [Abstract] [Full Text] [PDF]  

Toshimasa Tosaka, Mathew C. Casimiro, Qi Rong, Srihari Tella, Michelle Oh, Alexander N. Katchman, John C. Pezzullo, Karl Pfeifer, and Steven N. Ebert

Nicotine Induces a Long QT Phenotype in Kcnq1-Deficient Mouse Hearts
J Pharmacol Exp Ther 2003 306: 980-987. Published online May 23, 2003; 10.1124/jpet.103.053017 [Abstract] [Full Text] [PDF]  

Lasse E. Rasmussen and Ove A. Nedergaard

Effects of Reboxetine on Sympathetic Neuroeffector Transmission in Rabbit Carotid Artery
J Pharmacol Exp Ther 2003 306: 995-1002. Published online May 16, 2003; 10.1124/jpet.103.052233 [Abstract] [Full Text] [PDF]  

Michael A. Kandler, Katharina von der Hardt, Suleiman Mahfoud, Martin Chada, Ellen Schoof, Thomas Papadopoulos, Wolfgang Rascher, and Jörg Dötsch

Pilot Intervention: Aerosolized Adrenomedullin Reduces Pulmonary Hypertension
J Pharmacol Exp Ther 2003 306: 1021-1026. Published online May 15, 2003; 10.1124/jpet.103.049817 [Abstract] [Full Text] [PDF]  

Alexander Omelchenko, Ron Bouchard, Hoa Dinh Le, Platon Choptiany, Neeraj Visen, Mark Hnatowich, and Larry V. Hryshko

Inhibition of Canine (NCX1.1) and Drosophila (CALX1.1) Na⁺-Ca²⁺ Exchangers by 7-Chloro-3,5-dihydro-5-phenyl-1H-4,1-benzothiazepine-2-one (CGP-37157)
J Pharmacol Exp Ther 2003 306: 1050-1057. Published online June 13, 2003; 10.1124/jpet.103.053389 [Abstract] [Full Text] [PDF]  

Osman D. Suleymanov, James A. Szalony, Anita K. Salyers, Rhonda M. LaChance, John J. Parlow, Michael S. South, Rhonda S. Wood, and Nancy S. Nicholson

Pharmacological Interruption of Acute Thrombus Formation with Minimal Hemorrhagic Complications by a Small Molecule Tissue Factor/Factor VIIa Inhibitor: Comparison to Factor Xa and Thrombin Inhibition in a Nonhuman Primate Thrombosis Model
J Pharmacol Exp Ther 2003 306: 1115-1121. Published online June 26, 2003; 10.1124/jpet.103.052779 [Abstract] [Full Text] [PDF]  

Anne Louise Kjølbye, Carsten Boye Knudsen, Trine Jepsen, Bjarne Due Larsen, and Jørgen Søberg Petersen

Pharmacological Characterization of the New Stable Antiarrhythmic Peptide Analog Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH₂ (ZP123): In Vivo and in Vitro Studies
J Pharmacol Exp Ther 2003 306: 1191-1199. Published online June 26, 2003; 10.1124/jpet.103.052258 [Abstract] [Full Text] [PDF]  

Alexandre Brkovic, Almut Hattenberger, Evi Kostenis, Thomas Klabunde, Stefanie Flohr, Michael Kurz, Steve Bourgault, and Alain Fournier

Functional and Binding Characterizations of Urotensin II-Related Peptides in Human and Rat Urotensin II-Receptor Assay
J Pharmacol Exp Ther 2003 306: 1200-1209. Published online June 13, 2003; 10.1124/jpet.103.052415 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Neela Patel, Li Sun, Deborah Moshinsky, Hui Chen, Kathleen M. Leahy, Phuong Le, Katherine G. Moss, Xueyan Wang, Audie Rice, Danny Tam, A. Douglas Laird, Xiaoming Yu, Qingling Zhang, Cho Tang, Gerald McMahon, and Anthony Howlett

A Selective and Oral Small Molecule Inhibitor of Vascular Epithelial Growth Factor Receptor (VEGFR)-2 and VEGFR-1 Inhibits Neovascularization and Vascular Permeability
J Pharmacol Exp Ther 2003 306: 838-845. Published online May 23, 2003; 10.1124/jpet.103.052167 [Abstract] [Full Text] [PDF]  

Shao-Pii Onn, Allen A. Fienberg, and Anthony A. Grace

Dopamine Modulation of Membrane Excitability in Striatal Spiny Neurons is Altered in DARPP-32 Knockout Mice
J Pharmacol Exp Ther 2003 306: 870-879. Published online June 12, 2003; 10.1124/jpet.103.050062 [Abstract] [Full Text] [PDF]  

Yuichi Hashimoto, Takako Niikura, Tomohiro Chiba, Emi Tsukamoto, Hisae Kadowaki, Hideki Nishitoh, Yohichi Yamagishi, Miho Ishizaka, Marina Yamada, Mikiro Nawa, Kenzo Terashita, Sadakazu Aiso, Hidenori Ichijo, and Ikuo Nishimoto

The Cytoplasmic Domain of Alzheimer's Amyloid- Protein Precursor Causes Sustained Apoptosis Signal-Regulating Kinase 1/c-Jun NH₂-Terminal Kinase-Mediated Neurotoxic Signal via Dimerization
J Pharmacol Exp Ther 2003 306: 889-902. Published online June 26, 2003; 10.1124/jpet.103.051383 [Abstract] [Full Text] [PDF]  

Zoltán H. Néemeth, S. Joseph Leibovich, Edwin A. Deitch, E. Sylvester Vizi, Csaba Szabó, and György Haskó

cDNA Microarray Analysis Reveals a Nuclear Factor-B-Independent Regulation of Macrophage Function by Adenosine
J Pharmacol Exp Ther 2003 306: 1042-1049. Published online May 23, 2003; 10.1124/jpet.103.052944 [Abstract] [Full Text] [PDF]  

Ki Whan Hong, Ki Young Kim, Hwa Kyoung Shin, Jeong Hyun Lee, Jae Moon Choi, Yong-Geun Kwak, Chi Dae Kim, Won Suk Lee, and Byung Yong Rhim

Cilostazol Prevents Tumor Necrosis Factor--Induced Cell Death by Suppression of Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation and Activation of Akt/Cyclic AMP Response Element-Binding Protein Phosphorylation
J Pharmacol Exp Ther 2003 306: 1182-1190. Published online June 13, 2003; 10.1124/jpet.103.052365 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Nobuyuki Enomoto, Yoshiyuki Takei, Miyoko Hirose, Akira Konno, Tomoyoshi Shibuya, Shujiro Matsuyama, Satoko Suzuki, Kenichi Ikejima Tsuneo Kitamura, and Nobuhiro Sato

Prevention of Ethanol-Induced Liver Injury in Rats by an Agonist of Peroxisome Proliferator-Activated Receptor-, Pioglitazone
J Pharmacol Exp Ther 2003 306: 846-854. Published online June 12, 2003; 10.1124/jpet.102.047217 [Abstract] [Full Text] [PDF]  

Takaharu Nakajima, Tetsuji Takayama, Koji Miyanishi, Atsushi Nobuoka, Tsuyoshi Hayashi, Tomoyuki Abe, Junji Kato, Kiyoyuki Sakon, Yoshimitsu Naniwa, Hirohumi Tanabe, and Yoshiro Niitsu

Reversal of Multiple Drug Resistance in Cholangiocarcinoma by the Glutathione S-Transferase--Specific Inhibitor O¹-Hexadecyl--glutamyl-S-benzylcysteinyl-D-phenylglycine Ethylester
J Pharmacol Exp Ther 2003 306: 861-869. Published online June 12, 2003; 10.1124/jpet.103.052696 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Linda A. Egger, Jin Cao, Christine McCallum, Usha Kidambi, Gail Van Riper, Ermengilda McCauley, Richard A. Mumford, Thomas J. Lanza, Linus S. Lin, Stephen E. de Laszlo, David N. Young, Ginger Yang, Dennis C. Dean, Conrad E. Raab, Mike A. Wallace, Allen N. Jones, William K. Hagmann, John A. Schmidt, R. Blake Pepinsky, Daniel M. Scott, Wen-Cherng Lee, Mark A. Cornebise, and Patricia A. Detmers

A Small Molecule ₄₁/₄₇ Antagonist Differentiates between the Low-Affinity States of ₄₁ and ₄₇: Characterization of Divalent Cation Dependence
J Pharmacol Exp Ther 2003 306: 903-913. Published online May 23, 2003; 10.1124/jpet.102.047704 [Abstract] [Full Text] [PDF]  

Barbara L. Faubert Kaplan, Cheryl E. Rockwell, and Norbert E. Kaminski

Evidence for Cannabinoid Receptor-Dependent and -Independent Mechanisms of Action in Leukocytes
J Pharmacol Exp Ther 2003 306: 1077-1085. Published online June 12, 2003; 10.1124/jpet.103.051961 [Abstract] [Full Text] [PDF]  

Michael W. Konstan, Jeanne E. Krenicky, Marcie R. Finney, H. Lester Kirchner, Kathleen A. Hilliard, Jay B. Hilliard, Pamela B. Davis, and Charles L. Hoppel

Effect of Ibuprofen on Neutrophil Migration in Vivo in Cystic Fibrosis and Healthy Subjects
J Pharmacol Exp Ther 2003 306: 1086-1091. Published online June 13, 2003; 10.1124/jpet.103.052449 [Abstract] [Full Text] [PDF]  

Noriyuki Yamamoto, Keisuke Takeshita, Michitaka Shichijo, Toshio Kokubo, Masako Sato, Kosuke Nakashima, Mina Ishimori, Hiroichi Nagai, Ying-Fu Li, Takeshi Yura, and Kevin B. Bacon

The Orally Available Spleen Tyrosine Kinase Inhibitor 2-[7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide Dihydrochloride (BAY 61-3606) Blocks Antigen-Induced Airway Inflammation in Rodents
J Pharmacol Exp Ther 2003 306: 1174-1181. Published online May 23, 2003; 10.1124/jpet.103.052316 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

David S. Goldstein, Sheng-Ting Li, Courtney Holmes, and Krys Bankiewicz

Sympathetic Innervation in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Primate Model of Parkinson's Disease
J Pharmacol Exp Ther 2003 306: 855-860. Published online June 12, 2003; 10.1124/jpet.103.051714 [Abstract] [Full Text] [PDF]  

Sachin Patel, David J. Rademacher, and Cecilia J. Hillard

Differential Regulation of the Endocannabinoids Anandamide and 2-Arachidonylglycerol within the Limbic Forebrain by Dopamine Receptor Activity
J Pharmacol Exp Ther 2003 306: 880-888. Published online June 13, 2003; 10.1124/jpet.103.054270 [Abstract] [Full Text] [PDF]  

Xilong Zhao, Vincent L. Salgado, Jay Z. Yeh, and Toshio Narahashi

Differential Actions of Fipronil and Dieldrin Insecticides on GABA-Gated Chloride Channels in Cockroach Neurons
J Pharmacol Exp Ther 2003 306: 914-924. Published online May 23, 2003; 10.1124/jpet.103.051839 [Abstract] [Full Text] [PDF]  

Samer J. Nuwayhid and Linda L. Werling

Steroids Modulate N-Methyl-D-aspartate-Stimulated [³H]Dopamine Release from Rat Striatum via Receptors
J Pharmacol Exp Ther 2003 306: 934-940. Published online May 15, 2003; 10.1124/jpet.103.052324 [Abstract] [Full Text] [PDF]  

M. J. Millan, A. Gobert, F. Lejeune, A. Dekeyne, A. Newman-Tancredi, V. Pasteau, J.-M. Rivet, and D. Cussac

The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine_2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways
J Pharmacol Exp Ther 2003 306: 954-964. Published online May 15, 2003; 10.1124/jpet.103.051797 [Abstract] [Full Text] [PDF]  

Chitra D. Mandyam, Deepak R. Thakker, and Kelly M. Standifer

µ-Opioid-Induced Desensitization of Opioid Receptor-Like 1 and µ-Opioid Receptors: Differential Intracellular Signaling Determines Receptor Sensitivity
J Pharmacol Exp Ther 2003 306: 965-972. Published online May 15, 2003; 10.1124/jpet.103.051599 [Abstract] [Full Text] [PDF]  

Christine Brabeck, Ragen Pfeiffer, Alan Leake, Sascha Beneke, Ralph Meyer, and Alexander Bürkle

L-Selegiline Potentiates the Cellular Poly(ADP-Ribosyl)ation Response to Ionizing Radiation
J Pharmacol Exp Ther 2003 306: 973-979. Published online May 15, 2003; 10.1124/jpet.103.051342 [Abstract] [Full Text] [PDF]  

Murat Oz, Arippa Ravindran, Oscar Diaz-Ruiz, Li Zhang, and Marisela Morales

The Endogenous Cannabinoid Anandamide Inhibits ₇ Nicotinic Acetylcholine Receptor-Mediated Responses in Xenopus Oocytes
J Pharmacol Exp Ther 2003 306: 1003-1010. Published online May 23, 2003; 10.1124/jpet.103.049981 [Abstract] [Full Text] [PDF]  

Vladimir P. Grinevich, Peter A. Crooks, Sangeetha P. Sumithran, Aaron J. Haubner, Joshua T. Ayers, and Linda P. Dwoskin

N-n-Alkylpyridinium Analogs, a Novel Class of Nicotinic Receptor Antagonists: Selective Inhibition of Nicotine-Evoked [³H]Dopamine Overflow from Superfused Rat Striatal Slices
J Pharmacol Exp Ther 2003 306: 1011-1020. Published online May 23, 2003; 10.1124/jpet.103.051789 [Abstract] [Full Text] [PDF]  

J. E. Gibbs, T. Rashid, and S. A. Thomas

Effect of Transport Inhibitors and Additional Anti-HIV Drugs on the Movement of Lamivudine (3TC) across the Guinea Pig Brain Barriers
J Pharmacol Exp Ther 2003 306: 1035-1041. Published online May 23, 2003; 10.1124/jpet.103.053827 [Abstract] [Full Text] [PDF]  

Paul J. Kenny, Fabrizio Gasparini, and Athina Markou

Group II Metabotropic and -Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA)/Kainate Glutamate Receptors Regulate the Deficit in Brain Reward Function Associated with Nicotine Withdrawal in Rats
J Pharmacol Exp Ther 2003 306: 1068-1076. Published online June 12, 2003; 10.1124/jpet.103.052027 [Abstract] [Full Text] [PDF]  

Elizabeth M. Laurenzana, Melinda G. Gunnell, W. Brooks Gentry, and S. Michael Owens

Treatment of Adverse Effects of Excessive Phencyclidine Exposure in Rats with a Minimal Dose of Monoclonal Antibody
J Pharmacol Exp Ther 2003 306: 1092-1098. Published online June 26, 2003; 10.1124/jpet.103.053140 [Abstract] [Full Text] [PDF]  

Willias Masocha, Gyongyi Horvath, Ahmad Agil, María Ocaña, Esperanza Del Pozo, Margit Szikszay, and José M. Baeyens

Role of Na⁺,K⁺-ATPase in Morphine-Induced Antinociception
J Pharmacol Exp Ther 2003 306: 1122-1128. Published online May 19, 2003; 10.1124/jpet.103.052977 [Abstract] [Full Text] [PDF]  

H. Huang, X. Wu, G. D. Nicol, S. Meller, and M. R. Vasko

ATP Augments Peptide Release from Rat Sensory Neurons in Culture through Activation of P2Y Receptors
J Pharmacol Exp Ther 2003 306: 1137-1144. Published online June 26, 2003; 10.1124/jpet.103.052951 [Abstract] [Full Text] [PDF]  

Frank I. Tarazi, Ross J. Baldessarini, Nora S. Kula, and Kehong Zhang

Long-Term Effects of Olanzapine, Risperidone, and Quetiapine on Ionotropic Glutamate Receptor Types: Implications for Antipsychotic Drug Treatment
J Pharmacol Exp Ther 2003 306: 1145-1151. Published online June 26, 2003; 10.1124/jpet.103.052597 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Alina L. Micu, Sharon Miksys, Edward M. Sellers, Dennis R. Koop, and Rachel F. Tyndale

Rat Hepatic CYP2E1 Is Induced by Very Low Nicotine Doses: An Investigation of Induction, Time Course, Dose Response, and Mechanism
J Pharmacol Exp Ther 2003 306: 941-947. Published online May 15, 2003; 10.1124/jpet.103.052183 [Abstract] [Full Text] [PDF]  

Lei Zhang and Marie H. Hanigan

Role of Cysteine S-Conjugate -Lyase in the Metabolism of Cisplatin
J Pharmacol Exp Ther 2003 306: 988-994. Published online May 15, 2003; 10.1124/jpet.103.052225 [Abstract] [Full Text] [PDF]  

Ravindra K. Hajela, Shuang-Qing Peng, and William D. Atchison

Comparative Effects of Methylmercury and Hg²⁺ on Human Neuronal N- and R-Type High-Voltage Activated Calcium Channels Transiently Expressed in Human Embryonic Kidney 293 Cells
J Pharmacol Exp Ther 2003 306: 1129-1136. Published online June 12, 2003; 10.1124/jpet.103.049429 [Abstract] [Full Text] [PDF]  

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