PERSPECTIVES IN PHARMACOLOGY:

Hanns Ulrich Zeilhofer and Girolamo Calò

Nociceptin/Orphanin FQ and Its Receptor—Potential Targets for Pain Therapy?
J Pharmacol Exp Ther 2003 306: 423-429. Published online April 29, 2003; 10.1124/jpet.102.046979 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

P. Veng-Pedersen, S. Chapel, N. H. Al-Huniti, R. L. Schmidt, E. M. Sedars, R. J. Hohl, and J. A. Widness

A Differential Pharmacokinetic Analysis of the Erythropoietin Receptor Population in Newborn and Adult Sheep
J Pharmacol Exp Ther 2003 306: 532-537. Published online May 15, 2003; 10.1124/jpet.103.052431 [Abstract] [Full Text] [PDF]  

Jian Zong and Gary M. Pollack

Modulation of P-glycoprotein Transport Activity in the Mouse Blood-Brain Barrier by Rifampin
J Pharmacol Exp Ther 2003 306: 556-562. Published online April 29, 2003; 10.1124/jpet.103.049452 [Abstract] [Full Text] [PDF]  

Hideto Jinno, Mayumi Saeki, Yoshiro Saito, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Kimie Sai, Nahoko Kaniwa, Masanori Ando, Kuniaki Shirao, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, Shogo Ozawa, and Jun-Ichi Sawada

Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients
J Pharmacol Exp Ther 2003 306: 688-693. Published online May 1, 2003; 10.1124/jpet.103.051250 [Abstract] [Full Text] [PDF]  

Daisuke Kobayashi, Takashi Nozawa, Kozue Imai, Jun-ichi Nezu, Akira Tsuji, and Ikumi Tamai

Involvement of Human Organic Anion Transporting Polypeptide OATP-B (SLC21A9) in pH-Dependent Transport across Intestinal Apical Membrane
J Pharmacol Exp Ther 2003 306: 703-708. Published online April 30, 2003; 10.1124/jpet.103.051300 [Abstract] [Full Text] [PDF]  

Hsia-Lien Lin, Haoming Zhang, Lucy Waskell, and Paul F. Hollenberg

Threonine-205 in the F Helix of P450 2B1 Contributes to Androgen 16-Hydroxylation Activity and Mechanism-Based Inactivation
J Pharmacol Exp Ther 2003 306: 744-751. Published online April 29, 2003; 10.1124/jpet.103.050260 [Abstract] [Full Text] [PDF]  

Christopher P. Landowski, Duxin Sun, David R. Foster, Sujatha S. Menon, Jeffrey L. Barnett, Lynda S. Welage, Chandrasekharan Ramachandran, and Gordon L. Amidon

Gene Expression in the Human Intestine and Correlation with Oral Valacyclovir Pharmacokinetic Parameters
J Pharmacol Exp Ther 2003 306: 778-786. Published online May 15, 2003; 10.1124/jpet.103.051011 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Yukinori Nagakura, Masamichi Okada, Atsuyuki Kohara, Tetsuo Kiso, Takashi Toya, Akihiko Iwai, Fumikazu Wanibuchi, and Tokio Yamaguchi

Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics
J Pharmacol Exp Ther 2003 306: 490-497. Published online May 1, 2003; 10.1124/jpet.103.050781 [Abstract] [Full Text] [PDF]  

Kristof Deseure, Wouter Koek, Hugo Adriaensen, and Francis C. Colpaert

Continuous Administration of the 5-Hydroxytryptamine_1A Agonist (3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl) -amino]-methyl}piperidin-1-yl]-methadone (F 13640) Attenuates Allodynia-Like Behavior in a Rat Model of Trigeminal Neuropathic Pain
J Pharmacol Exp Ther 2003 306: 505-514. Published online May 2, 2003; 10.1124/jpet.103.050286 [Abstract] [Full Text] [PDF]  

Vasudeva Raghavendra, Flobert Tanga, and Joyce A. DeLeo

Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy
J Pharmacol Exp Ther 2003 306: 624-630. Published online May 6, 2003; 10.1124/jpet.103.052407 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Mark M. Knuepfer

Muscarinic Cholinergic and -Adrenergic Contribution to Hindquarters Vasodilation and Cardiac Responses to Cocaine
J Pharmacol Exp Ther 2003 306: 515-522. Published online May 1, 2003; 10.1124/jpet.103.051177 [Abstract] [Full Text] [PDF]  

Renaud Tissier, Karim Aouam, Alain Berdeaux, and Bijan Ghaleh

Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed Preconditioning in Rabbits
J Pharmacol Exp Ther 2003 306: 528-531. Published online May 2, 2003; 10.1124/jpet.103.052563 [Abstract] [Full Text] [PDF]  

Matthew R. Farmer, Richard E. Roberts, Sheila M. Gardiner, and Vera Ralevic

Effects of in Vivo Lipopolysaccharide Infusion on Vasoconstrictor Function of Rat Isolated Mesentery, Kidney, and Aorta
J Pharmacol Exp Ther 2003 306: 538-545. Published online May 2, 2003; 10.1124/jpet.103.051805 [Abstract] [Full Text] [PDF]  

Chun-Mei Cao, Qiang Xia, Iain C. Bruce, Xiong Zhang, Chen Fu, and Jun-Zhu Chen

Interleukin-2 Increases Activity of Sarcoplasmic Reticulum Ca²⁺-ATPase, but Decreases Its Sensitivity to Calcium in Rat Cardiomyocytes
J Pharmacol Exp Ther 2003 306: 572-580. Published online May 2, 2003; 10.1124/jpet.102.048264 [Abstract] [Full Text] [PDF]  

Ting-Ting Hong, Edward M. Driscoll, Andrew J. White, Ardaman Sherigill, Thierry A. Giboulot, and Benedict R. Lucchesi

Glycoprotein IIb/IIIa Receptor Antagonist (2S)-2-[(2-Naphthyl-sulfonyl)amino]-3-{[2-({4-(4-piperidinyl)-2-[2-(4-piperidinyl)ethyl] butanoyl}amino)acetyl]amino}propanoic Acid Dihydrochloride (CRL42796), in Combination with Aspirin and/or Enoxaparin, Prevents Coronary Artery Rethrombosis after Successful Thrombolytic Treatment by Recombinant Tissue Plasminogen Activator
J Pharmacol Exp Ther 2003 306: 616-623. Published online May 6, 2003; 10.1124/jpet.103.052886 [Abstract] [Full Text] [PDF]  

You-Tang Shen, Joseph J. Lynch, Richard J. Hargreaves, and Robert J. Gould

A Growth Hormone Secretagogue Prevents Ischemic-Induced Mortality Independently of the Growth Hormone Pathway in Dogs with Chronic Dilated Cardiomyopathy
J Pharmacol Exp Ther 2003 306: 815-820. Published online May 15, 2003; 10.1124/jpet.103.050997 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Xin Yu, Xin Mao, Allan D. Blake, Wen Xin Li, and Sulie L. Chang

Morphine and Endomorphins Differentially Regulate µ-Opioid Receptor mRNA in SHSY-5Y Human Neuroblastoma Cells
J Pharmacol Exp Ther 2003 306: 447-454. Published online May 16, 2003; 10.1124/jpet.103.048694 [Abstract] [Full Text] [PDF]  

Aaron N. Hata, Roy Zent, Matthew D. Breyer, and Richard M. Breyer

Expression and Molecular Pharmacology of the Mouse CRTH2 Receptor
J Pharmacol Exp Ther 2003 306: 463-470. Published online April 29, 2003; 10.1124/jpet.103.050955 [Abstract] [Full Text] [PDF]  

Deborah Lee, Anna Robeva, Zhongjian Chen, and Kenneth P. Minneman

Mutational Uncoupling of _1A-Adrenergic Receptors from G Proteins Also Uncouples Mitogenic and Transcriptional Responses in PC12 Cells
J Pharmacol Exp Ther 2003 306: 471-477. Published online April 30, 2003; 10.1124/jpet.103.050500 [Abstract] [Full Text] [PDF]  

Drew Everhart, Edward Reiller, Armen Mirzoian, J. Michael McIntosh, Arun Malhotra, and Charles W. Luetje

Identification of Residues That Confer -Conotoxin-PnIA Sensitivity on the 3 Subunit of Neuronal Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 2003 306: 664-670. Published online May 6, 2003; 10.1124/jpet.103.051656 [Abstract] [Full Text] [PDF]  

Adriana Bañuelos, Elba Reyes, Rodolfo Ocadiz, Elizabeth Alvarez, Martha Moreno, Alberto Monroy, and Patricio Gariglio

Neocarzinostatin Induces an Effective p53-Dependent Response in Human Papillomavirus-Positive Cervical Cancer Cells
J Pharmacol Exp Ther 2003 306: 671-680. Published online May 15, 2003; 10.1124/jpet.103.051557 [Abstract] [Full Text] [PDF]  

Se-Ne Huang, Mitch A. Phelps, and Peter W. Swaan

Involvement of Endocytic Organelles in the Subcellular Trafficking and Localization of Riboflavin
J Pharmacol Exp Ther 2003 306: 681-687. Published online April 29, 2003; 10.1124/jpet.103.051581 [Abstract] [Full Text] [PDF]  

Parimal Misra, Ranjan Chakrabarti, Reeba K. Vikramadithyan, Gopalakrishnan Bolusu, Suresh Juluri, Jagadheshan Hiriyan, Cynthia Gershome, Abdul Rajjak, Papreddy Kashireddy, Songtao Yu, Sailesh Surapureddi, Chao Qi, Yi-Jun Zhu, M. Sambasiva Rao, Janardan K. Reddy, and Rajagopalan Ramanujam

PAT5A: A Partial Agonist of Peroxisome Proliferator-Activated Receptor Is a Potent Antidiabetic Thiazolidinedione Yet Weakly Adipogenic
J Pharmacol Exp Ther 2003 306: 763-771. Published online May 2, 2003; 10.1124/jpet.103.049791 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Rodney A. Velliquette and Paul Ernsberger

The Role of I₁-Imidazoline and ₂-Adrenergic Receptors in the Modulation of Glucose Metabolism in the Spontaneously Hypertensive Obese Rat Model of Metabolic Syndrome X
J Pharmacol Exp Ther 2003 306: 646-657. Published online May 19, 2003; 10.1124/jpet.103.050468 [Abstract] [Full Text] [PDF]  

Jose M. Soares, Jr., Monica I. Masana, Çagatay Ersahin, and Margarita L. Dubocovich

Functional Melatonin Receptors in Rat Ovaries at Various Stages of the Estrous Cycle
J Pharmacol Exp Ther 2003 306: 694-702. Published online April 29, 2003; 10.1124/jpet.103.049916 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Mohamed H. Ahmed, Richard J. Balment, and Nick Ashton

Renal Action of Acute Chloroquine and Paracetamol Administration in the Anesthetized, Fluid-Balanced Rat
J Pharmacol Exp Ther 2003 306: 478-483. Published online April 29, 2003; 10.1124/jpet.103.051037 [Abstract] [Full Text] [PDF]  

Tadashi Tsubouchi, Takaharu Saito, Fujie Mizutani, Toshie Yamauchi, and Yuji Iwanaga

Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo
J Pharmacol Exp Ther 2003 306: 787-793. Published online April 30, 2003; 10.1124/jpet.102.048603 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Olga Pol, José R. Palacio, and Margarita M. Puig

The Expression of - and -Opioid Receptor Is Enhanced during Intestinal Inflammation in Mice
J Pharmacol Exp Ther 2003 306: 455-462. Published online April 30, 2003; 10.1124/jpet.103.049346 [Abstract] [Full Text] [PDF]  

Stephen J. Getting, Helgi B. Schiöth, and Mauro Perretti

Dissection of the Anti-Inflammatory Effect of the Core and C-Terminal (KPV) -Melanocyte-Stimulating Hormone Peptides
J Pharmacol Exp Ther 2003 306: 631-637. Published online May 15, 2003; 10.1124/jpet.103.051623 [Abstract] [Full Text] [PDF]  

Monica A. Summers, M. Sue O'Dorisio, Mary O. Cox, Maria Lara-Marquez, and Edward J. Goetzl

A Lymphocyte-Generated Fragment of Vasoactive Intestinal Peptide with VPAC1 Agonist Activity and VPAC2 Antagonist Effects
J Pharmacol Exp Ther 2003 306: 638-645. Published online May 15, 2003; 10.1124/jpet.103.050583 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Claire L. Neilan, Adam J. Janvey, Elizabeth Bolan, Irena Berezowska, Thi M.-D. Nguyen, Peter W. Schiller, and Gavril W. Pasternak

Characterization of the Binding of [³H][Dmt¹]H-Dmt-D-Arg-Phe-Lys-NH₂, a Highly Potent Opioid Peptide
J Pharmacol Exp Ther 2003 306: 430-436. Published online March 27, 2003; 10.1124/jpet.103.049742 [Abstract] [Full Text] [PDF]  

Sarah B. Appel, Zhaoping Liu, Maureen A. McElvain, and Mark S. Brodie

Ethanol Excitation of Dopaminergic Ventral Tegmental Area Neurons Is Blocked by Quinidine
J Pharmacol Exp Ther 2003 306: 437-446. Published online April 29, 2003; 10.1124/jpet.103.050963 [Abstract] [Full Text] [PDF]  

Masago Ishikawa and Raymond M. Quock

Role of Nitric-Oxide Synthase Isoforms in Nitrous Oxide Antinociception in Mice
J Pharmacol Exp Ther 2003 306: 484-489. Published online April 29, 2003; 10.1124/jpet.103.049551 [Abstract] [Full Text] [PDF]  

Xiaoping Zhou, Xiao-Wei Dong, James Crona, Maureen Maguire, and Tony Priestley

Vinpocetine Is a Potent Blocker of Rat Na_V1.8 Tetrodotoxin-Resistant Sodium Channels
J Pharmacol Exp Ther 2003 306: 498-504. Published online May 1, 2003; 10.1124/jpet.103.051086 [Abstract] [Full Text] [PDF]  

Tommi Möykkynen, Esa R. Korpi, and David M. Lovinger

Ethanol Inhibits -Amino-3-hydyroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Function in Central Nervous System Neurons by Stabilizing Desensitization
J Pharmacol Exp Ther 2003 306: 546-555. Published online May 6, 2003; 10.1124/jpet.103.050666 [Abstract] [Full Text] [PDF]  

K. J. Damjanoska, L. D. Van de Kar, G. H. Kindel, Y. Zhang, D. N. D'Souza, F. Garcia, G. Battaglia, and N. A. Muma

Chronic Fluoxetine Differentially Affects 5-Hydroxytryptamine_2A Receptor Signaling in Frontal Cortex, Oxytocin- and Corticotropin-Releasing Factor-Containing Neurons in Rat Paraventricular Nucleus
J Pharmacol Exp Ther 2003 306: 563-571. Published online April 29, 2003; 10.1124/jpet.103.050534 [Abstract] [Full Text] [PDF]  

Gavin Bart, Lisa Borg, James H. Schluger, Mark Green, Ann Ho, and Mary Jeanne Kreek

Suppressed Prolactin Response to Dynorphin A_1–13 in Methadone-Maintained Versus Control Subjects
J Pharmacol Exp Ther 2003 306: 581-587. Published online May 2, 2003; 10.1124/jpet.103.050682 [Abstract] [Full Text] [PDF]  

Li Ding-Zhou, Catherine Marchand-Verrecchia, Bruno Palmier, Nicole Croci, Pierre-Etienne Chabrier, Michel Plotkine, and Isabelle Margaill

Neuroprotective Effects of (S)-N-[4-[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)carbonyl]-1-piperazinyl]phenyl]-2-thiophenecarboximid-amide (BN 80933), an Inhibitor of Neuronal Nitric-Oxide Synthase and an Antioxidant, in Model of Transient Focal Cerebral Ischemia in Mice
J Pharmacol Exp Ther 2003 306: 588-594. Published online May 2, 2003; 10.1124/jpet.103.051490 [Abstract] [Full Text] [PDF]  

J. S. Sessoms-Sikes, Margaret E. Hamilton, Li-Xin Liu, David M. Lovinger, and Tina K. Machu

A Mutation in Transmembrane Domain II of the 5-Hydroxytryptamine_3A Receptor Stabilizes Channel Opening and Alters Alcohol Modulatory Actions
J Pharmacol Exp Ther 2003 306: 595-604. Published online May 2, 2003; 10.1124/jpet.103.050542 [Abstract] [Full Text] [PDF]  

Mihály Hajós, William E. Hoffmann, and Royal J. Weaver

Regulation of Septo-Hippocampal Activity by 5-Hydroxytryptamine_2C Receptors
J Pharmacol Exp Ther 2003 306: 605-615. Published online May 6, 2003; 10.1124/jpet.103.051169 [Abstract] [Full Text] [PDF]  

J. Piriz, M. D. Rosato Siri, R. Pagani, and O. D. Uchitel

Nifedipine-Mediated Mobilization of Intracellular Calcium Stores Increases Spontaneous Neurotransmitter Release at Neonatal Rat Motor Nerve Terminals
J Pharmacol Exp Ther 2003 306: 658-663. Published online May 2, 2003; 10.1124/jpet.103.051524 [Abstract] [Full Text] [PDF]  

Md Harunor Rashid, Makoto Inoue, Shiho Bakoshi, and Hiroshi Ueda

Increased Expression of Vanilloid Receptor 1 on Myelinated Primary Afferent Neurons Contributes to the Antihyperalgesic Effect of Capsaicin Cream in Diabetic Neuropathic Pain in Mice
J Pharmacol Exp Ther 2003 306: 709-717. Published online April 30, 2003; 10.1124/jpet.103.050948 [Abstract] [Full Text] [PDF]  

Teruo Hayashi and Tsung-Ping Su

-1 Receptors (₁ Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export
J Pharmacol Exp Ther 2003 306: 718-725. Published online May 2, 2003; 10.1124/jpet.103.051284 [Abstract] [Full Text] [PDF]  

Teruo Hayashi and Tsung-Ping Su

Intracellular Dynamics of -1 Receptors (₁ Binding Sites) in NG108-15 Cells
J Pharmacol Exp Ther 2003 306: 726-733. Published online May 2, 2003; 10.1124/jpet.103.051292 [Abstract] [Full Text] [PDF]  

Malgorzata Filip and Kathryn A. Cunningham

Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin_2C (5-HT_2C) Receptors in Rat Prefrontal Cortex
J Pharmacol Exp Ther 2003 306: 734-743. Published online April 29, 2003; 10.1124/jpet.102.045716 [Abstract] [Full Text] [PDF]  

Tracey K. Murray, Katherine Whalley, Christine S. Robinson, Mark A. Ward, Caroline A. Hicks, David Lodge, Jim L. Vandergriff, Polly Baumbarger, Edward Siuda, Mary Gates, Ann M. Ogden, Phil Skolnick, Dennis M. Zimmerman, Eric S. Nisenbaum, David Bleakman, and Michael J. O'Neill

LY503430, a Novel -Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Potentiator with Functional, Neuroprotective and Neurotrophic Effects in Rodent Models of Parkinson's Disease
J Pharmacol Exp Ther 2003 306: 752-762. Published online May 2, 2003; 10.1124/jpet.103.049445 [Abstract] [Full Text] [PDF]  

Yuki Takada, Atsushi Yonezawa, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko, Hachiro Sugimoto, and Akinori Akaike

Nicotinic Acetylcholine Receptor-Mediated Neuroprotection by Donepezil Against Glutamate Neurotoxicity in Rat Cortical Neurons
J Pharmacol Exp Ther 2003 306: 772-777. Published online May 6, 2003; 10.1124/jpet.103.050104 [Abstract] [Full Text] [PDF]  

Richard L. Hauger, J. Alberto Olivares-Reyes, Sandra Braun, Kevin J. Catt, and Frank M. Dautzenberg

Mediation of Corticotropin Releasing Factor Type 1 Receptor Phosphorylation and Desensitization by Protein Kinase C: A Possible Role in Stress Adaptation
J Pharmacol Exp Ther 2003 306: 794-803. Published online May 6, 2003; 10.1124/jpet.103.050088 [Abstract] [Full Text] [PDF]  

Gino Villetti, Marco Bergamaschi, Franco Bassani, Pier Tonino Bolzoni, Marisa Maiorino, Claudio Pietra, Ivano Rondelli, Philippe Chamiot-Clerc, Michele Simonato, and Mario Barbieri

Antinociceptive Activity of the N-Methyl-D-aspartate Receptor Antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in Experimental Models of Inflammatory and Neuropathic Pain
J Pharmacol Exp Ther 2003 306: 804-814. Published online May 15, 2003; 10.1124/jpet.103.050039 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Louise M. Winn, Perry M. Kim, and Jac A. Nickoloff

Oxidative Stress-Induced Homologous Recombination As a Novel Mechanism for Phenytoin-Initiated Toxicity
J Pharmacol Exp Ther 2003 306: 523-527. Published online May 2, 2003; 10.1124/jpet.103.052639 [Abstract] [Full Text] [PDF]  

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