ANNOUNCEMENTS:

Brian M. Cox

Announcement
J Pharmacol Exp Ther 2003 305: 799. [Full Text] [PDF]  

PERSPECTIVES IN PHARMACOLOGY:

David S. Goldstein, Graeme Eisenhofer, and Irwin J. Kopin

Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans
J Pharmacol Exp Ther 2003 305: 800-811. Published online March 20, 2003; 10.1124/jpet.103.049270 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Petr Pavek, Frantisek Staud, Zdenek Fendrich, Hana Sklenarova, Antonin Libra, Martina Novotna, Martin Kopecky, Milan Nobilis, and Vladimir Semecky

Examination of the Functional Activity of P-glycoprotein in the Rat Placental Barrier Using Rhodamine 123
J Pharmacol Exp Ther 2003 305: 1239-1250. Published online March 6, 2003; 10.1124/jpet.102.048470 [Abstract] [Full Text] [PDF]  

Ann-Charlotte Egnell, Brian Houston, and Scott Boyer

In Vivo CYP3A4 Heteroactivation Is a Possible Mechanism for the Drug Interaction between Felbamate and Carbamazepine
J Pharmacol Exp Ther 2003 305: 1251-1262. Published online January 24, 2003; 10.1124/jpet.102.047530 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Diana L. Cichewicz and Sandra P. Welch

Modulation of Oral Morphine Antinociceptive Tolerance and Naloxone-Precipitated Withdrawal Signs by Oral ⁹-Tetrahydrocannabinol
J Pharmacol Exp Ther 2003 305: 812-817. Published online February 11, 2003; 10.1124/jpet.102.046870 [Abstract] [Full Text] [PDF]  

Andrew C. Barrett, Eric S. Smith, and Mitchell J. Picker

Use of Irreversible Antagonists to Determine the Relative Efficacy of µ-Opioids in a Pigeon Drug Discrimination Procedure: Comparison of -Funaltrexamine and Clocinnamox
J Pharmacol Exp Ther 2003 305: 1061-1070. Published online March 20, 2003; 10.1124/jpet.102.047068 [Abstract] [Full Text] [PDF]  

Miyako Yoshida, Shigehiro Ohdo, Hiroshi Takane, Yuki Tomiyoshi, Ayaka Matsuo, Eiji Yukawa, and Shun Higuchi

Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice
J Pharmacol Exp Ther 2003 305: 1200-1205. Published online March 6, 2003; 10.1124/jpet.103.049031 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Julie M. Proudfoot, Kevin D. Croft, Ian B. Puddey, and Lawrence J. Beilin

Angiotensin II Type 1 Receptor Antagonists Inhibit Basal As Well As Low-Density Lipoprotein and Platelet-Activating Factor-Stimulated Human Monocyte Chemoattractant Protein-1
J Pharmacol Exp Ther 2003 305: 846-853. Published online March 6, 2003; 10.1124/jpet.102.047795 [Abstract] [Full Text] [PDF]  

Hossam A. Shaltout and Abdel A. Abdel-Rahman

Cyclosporine Induces Progressive Attenuation of Baroreceptor Heart Rate Response and Cumulative Pressor Response in Conscious Unrestrained Rats
J Pharmacol Exp Ther 2003 305: 966-973. Published online March 6, 2003; 10.1124/jpet.102.048447 [Abstract] [Full Text] [PDF]  

Keshore R. Bidasee, Karuna Nallani, Henry R. Besch, Jr., and U. Deniz Dincer

Streptozotocin-Induced Diabetes Increases Disulfide Bond Formation on Cardiac Ryanodine Receptor (RyR2)
J Pharmacol Exp Ther 2003 305: 989-998. Published online February 20, 2003; 10.1124/jpet.102.046201 [Abstract] [Full Text] [PDF]  

Regina Gisbert, Francisco Pérez-Vizcaino, Angel L. Cogolludo, María Antonia Noguera, María Dolores Ivorra, Juan Tamargo, and Pilar D'Ocon

Cytosolic Ca²⁺ and Phosphoinositide Hydrolysis Linked to Constitutively Active _1D-Adrenoceptors in Vascular Smooth Muscle
J Pharmacol Exp Ther 2003 305: 1006-1014. Published online March 6, 2003; 10.1124/jpet.102.046169 [Abstract] [Full Text] [PDF]  

Dan Chalothorn, Dan F. McCune, Stephanie E. Edelmann, Kimimasa Tobita, Bradley B. Keller, Robert D. Lasley, Dianne M. Perez, Akito Tanoue, Gozoh Tsujimoto, Ginell R. Post, and Michael T. Piascik

Differential Cardiovascular Regulatory Activities of the _1B- and _1D-Adrenoceptor Subtypes
J Pharmacol Exp Ther 2003 305: 1045-1053. Published online March 20, 2003; 10.1124/jpet.102.048553 [Abstract] [Full Text] [PDF]  

Y. Zhang, T. Tazzeo, S. Hirota, and L. J. Janssen

Vasodilatory and Electrophysiological Actions of 8-iso-Prostaglandin E₂ in Porcine Coronary Artery
J Pharmacol Exp Ther 2003 305: 1054-1060. Published online March 6, 2003; 10.1124/jpet.103.049353 [Abstract] [Full Text] [PDF]  

Cynthia L. Sundell, Patricia K. Somers, Charles Q. Meng, Lee K. Hoong, Ki-Ling Suen, Russell R. Hill, Laura K. Landers, Angela Chapman, Dustie Butteiger, Moira Jones, David Edwards, Alan Daugherty, Martin A. Wasserman, R. Wayne Alexander, Russell M. Medford, and Uday Saxena

AGI-1067: A Multifunctional Phenolic Antioxidant, Lipid Modulator, Anti-Inflammatory and Antiatherosclerotic Agent
J Pharmacol Exp Ther 2003 305: 1116-1123. Published online March 6, 2003; 10.1124/jpet.102.048132 [Abstract] [Full Text] [PDF]  

Min-Liang Si and Tony Jer-Fu Lee

Pb²⁺ Inhibition of Sympathetic ₇-Nicotinic Acetylcholine Receptor-Mediated Nitrergic Neurogenic Dilation in Porcine Basilar Arteries
J Pharmacol Exp Ther 2003 305: 1124-1131. Published online March 6, 2003; 10.1124/jpet.102.046854 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Hirotaka Ohishi, Ken-Ichi Furukawa, Koei Iwasaki, Kazumasa Ueyama, Akihiro Okada, Shigeru Motomura, Seiko Harata, and Satoshi Toh

Role of Prostaglandin I₂ in the Gene Expression Induced by Mechanical Stress in Spinal Ligament Cells Derived from Patients with Ossification of the Posterior Longitudinal Ligament
J Pharmacol Exp Ther 2003 305: 818-824. Published online February 11, 2003; 10.1124/jpet.102.047142 [Abstract] [Full Text] [PDF]  

Richard C. Zangar, Thomas A. Kocarek, Shang Shen, Nikki Bollinger, Michael S. Dahn, and Donna W. Lee

Suppression of Cytochrome P450 3A Protein Levels by Proteasome Inhibitors
J Pharmacol Exp Ther 2003 305: 872-879. Published online March 6, 2003; 10.1124/jpet.102.044628 [Abstract] [Full Text] [PDF]  

Vipa Chaipatikul, Horace H. Loh, and P. Y. Law

Ligand-Selective Activation of µ-Opioid Receptor: Demonstrated with Deletion and Single Amino Acid Mutations of Third Intracellular Loop Domain
J Pharmacol Exp Ther 2003 305: 909-918. Published online March 6, 2003; 10.1124/jpet.102.046219 [Abstract] [Full Text] [PDF]  

Stefano Laurora, Stefania Pizzimenti, Federica Briatore, Alessandra Fraioli, Maddalena Maggio, Patrizia Reffo, Carlo Ferretti, Mario Umberto Dianzani, and Giuseppina Barrera

Peroxisome Proliferator-Activated Receptor Ligands Affect Growth-Related Gene Expression in Human Leukemic Cells
J Pharmacol Exp Ther 2003 305: 932-942. Published online March 20, 2003; 10.1124/jpet.103.049098 [Abstract] [Full Text] [PDF]  

Batya Plotkin, Oksana Kaidanovich, Ilana Talior, and Hagit Eldar-Finkelman

Insulin Mimetic Action of Synthetic Phosphorylated Peptide Inhibitors of Glycogen Synthase Kinase-3
J Pharmacol Exp Ther 2003 305: 974-980. Published online March 6, 2003; 10.1124/jpet.102.047381 [Abstract] [Full Text] [PDF]  

Petrus J. Pauwels, Isabelle Rauly, and Thierry Wurch

Dissimilar Pharmacological Responses by a New Series of Imidazoline Derivatives at Precoupled and Ligand-Activated _2A-Adrenoceptor States: Evidence for Effector Pathway-Dependent Differential Antagonism
J Pharmacol Exp Ther 2003 305: 1015-1023. Published online March 20, 2003; 10.1124/jpet.102.048215 [Abstract] [Full Text] [PDF]  

Roland Seifert, Katharina Wenzel-Seifert, Tilmann Bürckstümmer, Heinz H. Pertz, Walter Schunack, Stefan Dove, Armin Buschauer, and Sigurd Elz

Multiple Differences in Agonist and Antagonist Pharmacology between Human and Guinea Pig Histamine H₁-Receptor
J Pharmacol Exp Ther 2003 305: 1104-1115. Published online March 6, 2003; 10.1124/jpet.103.049619 [Abstract] [Full Text] [PDF]  

Lingke Zhao, Yen-Ping Kuo, Andrew A. George, Jian-Hong Peng, Madhuri Singh Purandare, Katherine M. Schroeder, Ronald J. Lukas, and Jie Wu

Functional Properties of Homomeric, Human 7-Nicotinic Acetylcholine Receptors Heterologously Expressed in the SH-EP1 Human Epithelial Cell Line
J Pharmacol Exp Ther 2003 305: 1132-1141. Published online March 6, 2003; 10.1124/jpet.103.048777 [Abstract] [Full Text] [PDF]  

Ki Young Kim, Yung Woo Shin, Sun-Ok Kim, Hong Lim, Sung-Eun Yoo, and Ki Whan Hong

Antiangiogenic Effect of KR-31372 by Apoptosis via Mediation of Mitochondrial K_ATP Channel Opening and the Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation
J Pharmacol Exp Ther 2003 305: 1142-1149. Published online March 6, 2003; 10.1124/jpet.103.048819 [Abstract] [Full Text] [PDF]  

Ashutosh A. Kulkarni, Melvin D. Trousdale, Douglas Stevenson, Hovhannes J. Gukasyan, Michael H. I. Shiue, Kwang-Jin Kim, Russell W. Read, and Vincent H. L. Lee

Nucleotide-Induced Restoration of Conjunctival Chloride and Fluid Secretion in Adenovirus Type 5-Infected Pigmented Rabbit Eyes
J Pharmacol Exp Ther 2003 305: 1206-1211. Published online March 20, 2003; 10.1124/jpet.103.049221 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Jianguo Ma, Shaolan Li, Karin Reed, Ping Guo, and James M. Gallo

Pharmacodynamic-Mediated Effects of the Angiogenesis Inhibitor SU5416 on the Tumor Disposition of Temozolomide in Subcutaneous and Intracerebral Glioma Xenograft Models
J Pharmacol Exp Ther 2003 305: 833-839. Published online March 6, 2003; 10.1124/jpet.102.048587 [Abstract] [Full Text] [PDF]  

Daniel L. Gustafson, David Siegel, Jeffrey C. Rastatter, Andrea L. Merz, Jacqueline C. Parpal, Jadwiga K. Kepa, David Ross, and Michael E. Long

Kinetics of NAD(P)H:Quinone Oxidoreductase I (NQO1) Inhibition by Mitomycin C in Vitro and in Vivo
J Pharmacol Exp Ther 2003 305: 1079-1086. Published online March 20, 2003; 10.1124/jpet.103.050070 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Shuichi Tsuruoka, George J. Schwartz, Michi Wakaumi, Kenta Nishiki, Hisashi Yamamoto, Jeffrey M. Purkerson, and Akio Fujimura

Nitric Oxide Production Modulates Cyclosporin A-Induced Distal Renal Tubular Acidosis in the Rat
J Pharmacol Exp Ther 2003 305: 840-845. Published online March 6, 2003; 10.1124/jpet.102.048207 [Abstract] [Full Text] [PDF]  

Jason C. Lambert, Zhanxiang Zhou, Lipeng Wang, Zhenyuan Song, Craig J. Mcclain, and Y. James Kang

Prevention of Alterations in Intestinal Permeability Is Involved in Zinc Inhibition of Acute Ethanol-Induced Liver Damage in Mice
J Pharmacol Exp Ther 2003 305: 880-886. Published online March 6, 2003; 10.1124/jpet.102.047852 [Abstract] [Full Text] [PDF]  

Robbie L. Mcleod, Charlie A. Rizzo, Robert E. West, Jr., Robert Aslanian, Kevin Mccormick, Matthew Bryant, Yunsheng Hsieh, Walter Korfmacher, Garfield G. Mingo, LoriAnn Varty, Shirley M. Williams, Neng-Yang Shih, Robert W. Egan, and John A. Hey

Pharmacological Characterization of the Novel Histamine H₃-Receptor Antagonist N-(3,5-Dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)
J Pharmacol Exp Ther 2003 305: 1037-1044. Published online March 20, 2003; 10.1124/jpet.103.049254 [Abstract] [Full Text] [PDF]  

Maki Hasegawa, Hiroyuki Kusuhara, Hitoshi Endou, and Yuichi Sugiyama

Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat
J Pharmacol Exp Ther 2003 305: 1087-1097. Published online March 26, 2003; 10.1124/jpet.102.046847 [Abstract] [Full Text] [PDF]  

Joost Rothbarth, Ruud A. Woutersen, Rolf W. Sparidans, Cornelis J. H. van de Velde, and Gerard J. Mulder

Melphalan Antitumor Efficacy and Hepatotoxicity: The Effect of Variable Infusion Duration in the Hepatic Artery
J Pharmacol Exp Ther 2003 305: 1098-1103. Published online February 20, 2003; 10.1124/jpet.103.049379 [Abstract] [Full Text] [PDF]  

Minoru Satoh, Naoki Kashihara, Sohachi Fujimoto, Hideyuki Horike, Takehiko Tokura, Tamehachi Namikoshi, Tamaki Sasaki, and Hirofumi Makino

A Novel Free Radical Scavenger, Edarabone, Protects Against Cisplatin-Induced Acute Renal Damage in Vitro and in Vivo
J Pharmacol Exp Ther 2003 305: 1183-1190. Published online March 20, 2003; 10.1124/jpet.102.047522 [Abstract] [Full Text] [PDF]  

Brigitta M. Peskar, Nadia Sawka, Karlheinz Ehrlich, and Bernhard A. Peskar

Role of Cyclooxygenase-1 and -2, Phospholipase C, and Protein Kinase C in Prostaglandin-Mediated Gastroprotection
J Pharmacol Exp Ther 2003 305: 1233-1238. Published online March 6, 2003; 10.1124/jpet.103.049650 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Prem N. Yadav, Zhihua Liu, and Mohamed M. Rafi

A Diarylheptanoid from Lesser Galangal (Alpinia officinarum) Inhibits Proinflammatory Mediators via Inhibition of Mitogen-Activated Protein Kinase, p44/42, and Transcription Factor Nuclear Factor-B
J Pharmacol Exp Ther 2003 305: 925-931. Published online March 6, 2003; 10.1124/jpet.103.049171 [Abstract] [Full Text] [PDF]  

Salahuddin Ahmed, Ayesha Rahman, Absarul Hasnain, Victor M. Goldberg, and Tariq M. Haqqi

Phenyl N-tert-Butylnitrone Down-Regulates Interleukin-1-Stimulated Matrix Metalloproteinase-13 Gene Expression in Human Chondrocytes: Suppression of c-Jun NH₂-Terminal Kinase, p38-Mitogen-Activated Protein Kinase and Activating Protein-1
J Pharmacol Exp Ther 2003 305: 981-988. Published online March 6, 2003; 10.1124/jpet.102.048611 [Abstract] [Full Text] [PDF]  

D. R. Leone, K. Giza, A. Gill, B. M. Dolinski, W. Yang, S. Perper, D. M. Scott, W.-C. Lee, M. Cornebise, K. Wortham, C. Nickerson-Nutter, L. L. Chen, D. LePage, J. C. Spell, E. T. Whalley, R. C. Petter, S. P. Adams, R. R. Lobb, and R. B. Pepinsky

An Assessment of the Mechanistic Differences Between Two Integrin ₄₁ Inhibitors, the Monoclonal Antibody TA-2 and the Small Molecule BIO5192, in Rat Experimental Autoimmune Encephalomyelitis
J Pharmacol Exp Ther 2003 305: 1150-1162. Published online March 6, 2003; 10.1124/jpet.102.047332 [Abstract] [Full Text] [PDF]  

Claudia L. Hofstra, Pragnya J. Desai, Robin L. Thurmond, and Wai-Ping Fung-Leung

Histamine H₄ Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells
J Pharmacol Exp Ther 2003 305: 1212-1221. Published online March 6, 2003; 10.1124/jpet.102.046581 [Abstract] [Full Text] [PDF]  

Peter H. Schafer, Anita K. Gandhi, Michelle A. Loveland, Roger S. Chen, Hon-Wah Man, Paul P. M. Schnetkamp, Gregor Wolbring, Sowmya Govinda, Laura G. Corral, Faribourz Payvandi, George W. Muller, and David I. Stirling

Enhancement of Cytokine Production and AP-1 Transcriptional Activity in T Cells by Thalidomide-Related Immunomodulatory Drugs
J Pharmacol Exp Ther 2003 305: 1222-1232. Published online March 20, 2003; 10.1124/jpet.102.048496 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Mia Engström, Annika Brandt, Siegfried Wurster, Juha-Matti Savola, and Pertti Panula

Prolactin Releasing Peptide Has High Affinity and Efficacy at Neuropeptide FF2 Receptors
J Pharmacol Exp Ther 2003 305: 825-832. Published online February 20, 2003; 10.1124/jpet.102.047118 [Abstract] [Full Text] [PDF]  

Y. A. Blednov, D. Walker, H. Alva, K. Creech, G. Findlay, and R. A. Harris

GABA_A Receptor 1 and 2 Subunit Null Mutant Mice: Behavioral Responses to Ethanol
J Pharmacol Exp Ther 2003 305: 854-863. Published online March 6, 2003; 10.1124/jpet.103.049478 [Abstract] [Full Text] [PDF]  

Thomas A. Lanz, Carol S. Himes, Giovanni Pallante, Lisa Adams, Shinji Yamazaki, Ben Amore, and Kalpana M. Merchant

The -Secretase Inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl Ester Reduces A Levels in Vivo in Plasma and Cerebrospinal Fluid in Young (Plaque-Free) and Aged (Plaque-Bearing) Tg2576 Mice
J Pharmacol Exp Ther 2003 305: 864-871. Published online March 6, 2003; 10.1124/jpet.102.048280 [Abstract] [Full Text] [PDF]  

Timothy A. Esbenshade, Kathleen M. Krueger, Thomas R. Miller, Chae Hee Kang, Lynne I. Denny, David G. Witte, Betty B. Yao, Gerard B. Fox, Ramin Faghih, Youssef L. Bennani, Michael Williams, and Arthur A. Hancock

Two Novel and Selective Nonimidazole Histamine H₃ Receptor Antagonists A-304121 and A-317920: I. In Vitro Pharmacological Effects
J Pharmacol Exp Ther 2003 305: 887-896. Published online February 20, 2003; 10.1124/jpet.102.047183 [Abstract] [Full Text] [PDF]  

Gerard B. Fox, Jia Bao Pan, Richard J. Radek, Angela M. Lewis, R. Scott Bitner, Timothy A. Esbenshade, Ramin Faghih, Youssef L. Bennani, Michael Williams, Betty B. Yao, Michael W. Decker, and Arthur A. Hancock

Two Novel and Selective Nonimidazole H₃ Receptor Antagonists A-304121 and A-317920: II. In Vivo Behavioral and Neurophysiological Characterization
J Pharmacol Exp Ther 2003 305: 897-908. Published online February 20, 2003; 10.1124/jpet.102.047241 [Abstract] [Full Text] [PDF]  

S. K. Joshi and G. F. Gebhart

Nonopioid Actions of U50,488 Enantiomers Contribute to Their Peripheral Cutaneous Antinociceptive Effects
J Pharmacol Exp Ther 2003 305: 919-924. Published online March 6, 2003; 10.1124/jpet.103.049023 [Abstract] [Full Text] [PDF]  

Alberto Chiarugi, Elena Meli, Maura Calvani, Roberta Picca, Roberto Baronti, Emidio Camaioni, Gabriele Costantino, Maura Marinozzi, Domenico E. Pellegrini-Giampietro, Roberto Pellicciari, and Flavio Moroni

Novel Isoquinolinone-Derived Inhibitors of Poly(ADP-ribose) Polymerase-1: Pharmacological Characterization and Neuroprotective Effects in an in Vitro Model of Cerebral Ischemia
J Pharmacol Exp Ther 2003 305: 943-949. Published online February 20, 2003; 10.1124/jpet.103.048934 [Abstract] [Full Text] [PDF]  

Xinhui Li, Dawn Conklin, Hui-Lin Pan, and James C. Eisenach

Allosteric Adenosine Receptor Modulation Reduces Hypersensitivity Following Peripheral Inflammation by a Central Mechanism
J Pharmacol Exp Ther 2003 305: 950-955. Published online February 20, 2003; 10.1124/jpet.102.047951 [Abstract] [Full Text] [PDF]  

Twum-Ampofo Ansah, Sammanda Ramamoorthy, Sylvia Montañez, Lynette C. Daws, and Randy D. Blakely

Calcium-Dependent Inhibition of Synaptosomal Serotonin Transport by the ₂-Adrenoceptor Agonist 5-Bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304)
J Pharmacol Exp Ther 2003 305: 956-965. Published online March 6, 2003; 10.1124/jpet.102.047134 [Abstract] [Full Text] [PDF]  

Gary E. Duncan, Seiya Miyamoto, and Jeffrey A. Lieberman

Chronic Administration of Haloperidol and Olanzapine Attenuates Ketamine-Induced Brain Metabolic Activation
J Pharmacol Exp Ther 2003 305: 999-1005. Published online March 6, 2003; 10.1124/jpet.102.048140 [Abstract] [Full Text] [PDF]  

Marek Samochocki, Anja Höffle, Andreas Fehrenbacher, Ruth Jostock, Jürgen Ludwig, Claudia Christner, Martin Radina, Marion Zerlin, Christoph Ullmer, Edna F. R. Pereira, Hermann Lübbert, Edson X. Albuquerque, and Alfred Maelicke

Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors
J Pharmacol Exp Ther 2003 305: 1024-1036. Published online March 20, 2003; 10.1124/jpet.102.045773 [Abstract] [Full Text] [PDF]  

P. A. Ferchmin, Dinely Perez, Vesna A. Eterovic, and Jean de Vellis

Nicotinic Receptors Differentially Regulate N-Methyl-D-aspartate Damage in Acute Hippocampal Slices
J Pharmacol Exp Ther 2003 305: 1071-1078. Published online March 20, 2003; 10.1124/jpet.102.048173 [Abstract] [Full Text] [PDF]  

Richard B. Rothman, Robert D. Clark, John S. Partilla, and Michael H. Baumann

(+)-Fenfluramine and Its Major Metabolite, (+)-Norfenfluramine, Are Potent Substrates for Norepinephrine Transporters
J Pharmacol Exp Ther 2003 305: 1191-1199. Published online March 20, 2003; 10.1124/jpet.103.049684 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Lawrence H. Lash, David A. Putt, Sarah E. Hueni, Renee J. Krause, and Adnan A. Elfarra

Roles of Necrosis, Apoptosis, and Mitochondrial Dysfunction in S-(1,2-Dichlorovinyl)-L-cysteine Sulfoxide-Induced Cytotoxicity in Primary Cultures of Human Renal Proximal Tubular Cells
J Pharmacol Exp Ther 2003 305: 1163-1172. Published online March 6, 2003; 10.1124/jpet.102.046185 [Abstract] [Full Text] [PDF]  

Michael D. Aleo, Gregg R. Lundeen, David K. Blackwell, Ward M. Smith, Gerald L. Coleman, Stanley W. Stadnicki, and William M. Kluwe

Mechanism and Implications of Brown Adipose Tissue Proliferation in Rats and Monkeys Treated with the Thiazolidinedione Darglitazone, a Potent Peroxisome Proliferator-Activated Receptor- Agonist
J Pharmacol Exp Ther 2003 305: 1173-1182. Published online March 6, 2003; 10.1124/jpet.102.042648 [Abstract] [Full Text] [PDF]  

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