PERSPECTIVES IN PHARMACOLOGY:

Lawrence H. Lash, Ronald N. Hines, Frank J. Gonzalez, Timothy R. Zacharewski, and Mark A. Rothstein

Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile?
J Pharmacol Exp Ther 2003 305: 403-409. Published online January 24, 2003; 10.1124/jpet.102.039925 [Abstract] [Full Text] [PDF]  

Keith A. Gary, Kevin A. Sevarino, George G. Yarbrough, Arthur J. Prange, Jr., and Andrew Winokur

The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics
J Pharmacol Exp Ther 2003 305: 410-416. Published online February 20, 2003; 10.1124/jpet.102.044040 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Undi Hoffler, Hisham A. El-Masri, and Burhan I. Ghanayem

Cytochrome P450 2E1 (CYP2E1) Is the Principal Enzyme Responsible for Urethane Metabolism: Comparative Studies Using CYP2E1-Null and Wild-Type Mice
J Pharmacol Exp Ther 2003 305: 557-564. Published online January 24, 2003; 10.1124/jpet.103.049072 [Abstract] [Full Text] [PDF] Correction  

D. E. Keyler, D. Shoeman, M. G. LeSage, A. D. Calvin, and P. R. Pentel

Maternal Vaccination Against Nicotine Reduces Nicotine Distribution to Fetal Brain in Rats
J Pharmacol Exp Ther 2003 305: 587-592. Published online February 11, 2003; 10.1124/jpet.102.046805 [Abstract] [Full Text] [PDF]  

Sayeepriyadarshini Anakk, Chun Ying Ku, Mary Vore, and Henry W. Strobel

Insights into Gender Bias: Rat Cytochrome P450 3A9
J Pharmacol Exp Ther 2003 305: 703-709. Published online February 11, 2003; 10.1124/jpet.102.048090 [Abstract] [Full Text] [PDF]  

María J. Garrido, Onintza Sayar, Cristina Segura, Javier Rapado, María Carmen Dios-Viéitez, María Jesús Renedo, and Iñaki F. Trocóniz

Pharmacokinetic/Pharmacodynamic Modeling of the Antinociceptive Effects of (+)-Tramadol in the Rat: Role of Cytochrome P450 2D Activity
J Pharmacol Exp Ther 2003 305: 710-718. Published online February 11, 2003; 10.1124/jpet.102.047779 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

M. Gulinello and S. S. Smith

Anxiogenic Effects of Neurosteroid Exposure: Sex Differences and Altered GABA_A Receptor Pharmacology in Adult Rats
J Pharmacol Exp Ther 2003 305: 541-548. Published online February 11, 2003; 10.1124/jpet.102.045120 [Abstract] [Full Text] [PDF]  

Matthew C. Lee, Forrest L. Smith, David L. Stevens, and Sandra P. Welch

The Role of Several Kinases in Mice Tolerant to ⁹-Tetrahydrocannabinol
J Pharmacol Exp Ther 2003 305: 593-599. Published online February 11, 2003; 10.1124/jpet.102.044446 [Abstract] [Full Text] [PDF]  

Lawrence P. Carter, Lauren R. Flores, Huifang Wu, Weibin Chen, Andrew W. Unzeitig, Andy Coop, and Charles P. France

The Role of GABA_B Receptors in the Discriminative Stimulus Effects of -Hydroxybutyrate in Rats: Time Course and Antagonism Studies
J Pharmacol Exp Ther 2003 305: 668-674. Published online February 11, 2003; 10.1124/jpet.102.047860 [Abstract] [Full Text] [PDF]  

Huifang Wu, Nick Zink, Lawrence P. Carter, Ashok K. Mehta, R. Jason Hernandez, Maharaj K. Ticku, Richard Lamb, Charles P. France, and Andrew Coop

A Tertiary Alcohol Analog of -Hydroxybutyric Acid as a Specific -Hydroxybutyric Acid Receptor Ligand
J Pharmacol Exp Ther 2003 305: 675-679. Published online January 21, 2003; 10.1124/jpet.102.046797 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Irina Korichneva, John Waka, and Ulrich Hammerling

Regulation of the Cardiac Mitochondrial Membrane Potential by Retinoids
J Pharmacol Exp Ther 2003 305: 426-433. Published online January 24, 2003; 10.1124/jpet.103.048900 [Abstract] [Full Text] [PDF]  

Liping Gao, Chongxue Zhu, and Edwin K. Jackson

₂-Adrenoceptors Potentiate Angiotensin II- and Vasopressin-Induced Renal Vasoconstriction in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2003 305: 581-586. Published online February 11, 2003; 10.1124/jpet.102.047647 [Abstract] [Full Text] [PDF]  

Toshio Obata, Hidetoshi Yonemochi, and Makoto Arita

Norepinephrine Evoked by Potassium Depolarization Increases Interstitial Adenosine Concentration via Activation of ecto-5'-Nucleotidase in Rat Hearts
J Pharmacol Exp Ther 2003 305: 719-724. Published online February 11, 2003; 10.1124/jpet.102.039917 [Abstract] [Full Text] [PDF]  

Robert Létienne, Yvan Verscheure, Michel Perez, Bruno Le Grand, Francis C. Colpaert, and Gareth W. John

Donitriptan Selectively Decreases Jugular Venous Oxygen Saturation in the Anesthetized Pig: Further Insights into Its Mechanism of Action Relevant to Headache Relief
J Pharmacol Exp Ther 2003 305: 749-754. Published online February 11, 2003; 10.1124/jpet.102.047225 [Abstract] [Full Text] [PDF]  

M. Rocchetti, A. Besana, G. Mostacciuolo, P. Ferrari, R. Micheletti, and A. Zaza

Diverse Toxicity Associated with Cardiac Na⁺/K⁺ Pump Inhibition: Evaluation of Electrophysiological Mechanisms
J Pharmacol Exp Ther 2003 305: 765-771. Published online February 20, 2003; 10.1124/jpet.102.047696 [Abstract] [Full Text] [PDF]  

D. F. Woodward, A. H.-P. Krauss, J. Chen, Y. Liang, C. Li, C. E. Protzman, A. Bogardus, R. Chen, K. M. Kedzie, H. A. Krauss, D. W. Gil, A. Kharlamb, L. A. Wheeler, D. Babusis, D. Welty, D. D.-S. Tang-Liu, M. Cherukury, S. W. Andrews, R. M. Burk, and M. E. Garst

Pharmacological Characterization of a Novel Antiglaucoma Agent, Bimatoprost (AGN 192024)
J Pharmacol Exp Ther 2003 305: 772-785. Published online January 24, 2003; 10.1124/jpet.102.047837 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Janice Y. Zhou, Peter T. Toth, and Richard J. Miller

Direct Interactions between the Heterotrimeric G Protein Subunit G5 and the G Protein Subunit-Like Domain-Containing Regulator of G Protein Signaling 11: Gain of Function of Cyan Fluorescent Protein-Tagged G3
J Pharmacol Exp Ther 2003 305: 460-466. Published online February 11, 2003; 10.1124/jpet.102.048637 [Abstract] [Full Text] [PDF]  

Jong-M. Kim, Hae R. Bae, Bong S. Park, Je M. Lee, Hee B. Ahn, Jee H. Rho, Kyung W. Yoo, Woo C. Park, Sae H. Rho, Hee S. Yoon, and Young Hyun Yoo

Early Mitochondrial Hyperpolarization and Intracellular Alkalinization in Lactacystin-Induced Apoptosis of Retinal Pigment Epithelial Cells
J Pharmacol Exp Ther 2003 305: 474-481. Published online February 11, 2003; 10.1124/jpet.102.047811 [Abstract] [Full Text] [PDF]  

A. Banan, A. Farhadi, J. Z. Fields, L. J. Zhang, M. Shaikh, and A. Keshavarzian

The -Isoform of Protein Kinase C Causes Inducible Nitric-Oxide Synthase and Nitric Oxide Up-Regulation: Key Mechanism for Oxidant-Induced Carbonylation, Nitration, and Disassembly of the Microtubule Cytoskeleton and Hyperpermeability of Barrier of Intestinal Epithelia
J Pharmacol Exp Ther 2003 305: 482-494. Published online February 11, 2003; 10.1124/jpet.102.047308 [Abstract] [Full Text] [PDF]  

Sylwia Ammoun, Tomas Holmqvist, Ramin Shariatmadari, Hendrica B. Oonk, Michel Detheux, Marc Parmentier, Karl E. O. Åkerman, and Jyrki P. Kukkonen

Distinct Recognition of OX₁ and OX₂ Receptors by Orexin Peptides
J Pharmacol Exp Ther 2003 305: 507-514. Published online January 24, 2003; 10.1124/jpet.102.048025 [Abstract] [Full Text] [PDF]  

Jian-Guo Li, Fengqin Zhang, Xi-Lu Jin, and Lee-Yuan Liu-Chen

Differential Regulation of the Human Opioid Receptor by Agonists: Etorphine and Levorphanol Reduced Dynorphin A- and U50,488H-Induced Internalization and Phosphorylation
J Pharmacol Exp Ther 2003 305: 531-540. Published online January 24, 2003; 10.1124/jpet.102.045559 [Abstract] [Full Text] [PDF]  

Xi-Lin Chen, Qiang Zhang, Ruozhi Zhao, Xiaoyu Ding, Pradyumna E. Tummala, and Russell M. Medford

Rac1 and Superoxide Are Required for the Expression of Cell Adhesion Molecules Induced by Tumor Necrosis Factor- in Endothelial Cells
J Pharmacol Exp Ther 2003 305: 573-580. Published online February 11, 2003; 10.1124/jpet.102.047894 [Abstract] [Full Text] [PDF]  

G. Hawcroft, S. H. Gardner, and M. A. Hull

Activation of Peroxisome Proliferator-Activated Receptor Does Not Explain the Antiproliferative Activity of the Nonsteroidal Anti-Inflammatory Drug Indomethacin on Human Colorectal Cancer Cells
J Pharmacol Exp Ther 2003 305: 632-637. Published online February 11, 2003; 10.1124/jpet.103.048769 [Abstract] [Full Text] [PDF]  

Kyoungho Suk, Heasuk Lee, Sang Soo Kang, Gyeong Jae Cho, and Wan Sung Choi

Flavonoid Baicalein Attenuates Activation-Induced Cell Death of Brain Microglia
J Pharmacol Exp Ther 2003 305: 638-645. Published online January 21, 2003; 10.1124/jpet.102.047373 [Abstract] [Full Text] [PDF]  

Keith Williams, Michael Dattilo, Thomas N. Sabado, Keiko Kashiwagi, and Kazuei Igarashi.

Pharmacology of 2 Glutamate Receptors: Effects of Pentamidine and Protons
J Pharmacol Exp Ther 2003 305: 740-748. Published online February 11, 2003; 10.1124/jpet.102.045799 [Abstract] [Full Text] [PDF]  

Francesca Novi, Marco Scarselli, Giovanni U. Corsini, and Roberto Maggio

An Unusual Form of the Association Binding Kinetics of N-[³H]Methylscopolamine to the Split Muscarinic M_2trunk/M_2tail Receptor
J Pharmacol Exp Ther 2003 305: 786-795. Published online January 24, 2003; 10.1124/jpet.102.045393 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Alberta Bergamo, Gabriele Stocco, Barbara Gava, Moreno Cocchietto, Enzo Alessio, Barbara Serli, Elisabetta Iengo, and Gianni Sava

Distinct Effects of Dinuclear Ruthenium(III) Complexes on Cell Proliferation and on Cell Cycle Regulation in Human and Murine Tumor Cell Lines
J Pharmacol Exp Ther 2003 305: 725-732. Published online February 11, 2003; 10.1124/jpet.102.047803 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

M. A. Serrano, R. I. R. Macias, M. Vallejo, O. Briz, A. Bravo, M. J. Pascual, M. V. St-Pierre, B. Stieger, P. J. Meier, and J. J. G. Marin

Effect of Ursodeoxycholic Acid on the Impairment Induced by Maternal Cholestasis in the Rat Placenta-Maternal Liver Tandem Excretory Pathway
J Pharmacol Exp Ther 2003 305: 515-524. Published online January 24, 2003; 10.1124/jpet.102.047977 [Abstract] [Full Text] [PDF]  

Jo Ann Janovick, Mark Goulet, Eugene Bush, Jonathan Greer, David G. Wettlaufer, and P. Michael Conn

Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor
J Pharmacol Exp Ther 2003 305: 608-614. Published online February 11, 2003; 10.1124/jpet.102.048454 [Abstract] [Full Text] [PDF]  

Kenna L. Anderes, David R. Luthin, Rosemary Castillo, Eugenia A. Kraynov, Mary Castro, Karen Nared-Hood, Margaret L. Gregory, Ved P. Pathak, Lance C. Christie, Genevieve Paderes, Haresh Vazir, Qiang Ye, Mark B. Anderson, and John M. May

Biological Characterization of a Novel, Orally Active Small Molecule Gonadotropin-Releasing Hormone (GnRH) Antagonist Using Castrated and Intact Rats
J Pharmacol Exp Ther 2003 305: 688-695. Published online January 24, 2003; 10.1124/jpet.102.046656 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Carolyn B. Coyne, Carla M. P. Ribeiro, Richard C. Boucher, and Larry G. Johnson

Acute Mechanism of Medium Chain Fatty Acid-Induced Enhancement of Airway Epithelial Permeability
J Pharmacol Exp Ther 2003 305: 440-450. Published online February 11, 2003; 10.1124/jpet.102.047654 [Abstract] [Full Text] [PDF]  

Zoltán Kapui, Márton Varga, Katalin Urban-Szabó, Endre Mikus, Tibor Szabó, Judit Szeredi, Sándor Bátori, Olivier Finance, and Péter Arányi

Biochemical and Pharmacological Characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a Novel, Orally Active Elastase Inhibitor
J Pharmacol Exp Ther 2003 305: 451-459. Published online February 11, 2003; 10.1124/jpet.102.044263 [Abstract] [Full Text] [PDF]  

Florian Loher, Kathrin Schmall, Philipp Freytag, Nikola Landauer, Roland Hallwachs, Christian Bauer, Britta Siegmund, Florian Rieder, Hans-Anton Lehr, Marc Dauer, Joachim Friedrich Kapp, Stefan Endres, and Andreas Eigler

The Specific Type-4 Phosphodiesterase Inhibitor Mesopram Alleviates Experimental Colitis in Mice
J Pharmacol Exp Ther 2003 305: 549-556. Published online February 11, 2003; 10.1124/jpet.102.039529 [Abstract] [Full Text] [PDF]  

Sandeep Rathi, Shiva Kazerounian, Kuldip Banwait, Stephanie Schulz, Scott A. Waldman, and Satish Rattan

Functional and Molecular Characterization of -Adrenoceptors in the Internal Anal Sphincter
J Pharmacol Exp Ther 2003 305: 615-624. Published online February 11, 2003; 10.1124/jpet.102.048462 [Abstract] [Full Text] [PDF]  

Inge Depoortere, Theo Thijs, Leen Thielemans, Patrick Robberecht, and Theo L. Peeters

Interaction of the Growth Hormone-Releasing Peptides Ghrelin and Growth Hormone-Releasing Peptide-6 with the Motilin Receptor in the Rabbit Gastric Antrum
J Pharmacol Exp Ther 2003 305: 660-667. Published online February 11, 2003; 10.1124/jpet.102.047563 [Abstract] [Full Text] [PDF]  

Benedict T. Green, Andrew Calvin, Scott M. O'Grady, and David R. Brown

Kinin-Induced Anion-Dependent Secretion in Porcine Ileum: Characterization and Involvement of Opioid- and Cannabinoid-Sensitive Enteric Neural Circuits
J Pharmacol Exp Ther 2003 305: 733-739. Published online February 11, 2003; 10.1124/jpet.102.047829 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Bryan L. Copple, Frederic Moulin, Umesh M. Hanumegowda, Patricia E. Ganey, and Robert A. Roth

Thrombin and Protease-Activated Receptor-1 Agonists Promote Lipopolysaccharide-Induced Hepatocellular Injury in Perfused Livers
J Pharmacol Exp Ther 2003 305: 417-425. Published online January 24, 2003; 10.1124/jpet.102.046391 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Michelle L. Gilmor, Kelly H. Skelton, Charles B. Nemeroff, and Michael J. Owens

The Effects of Chronic Treatment with the Mood Stabilizers Valproic Acid and Lithium on Corticotropin-Releasing Factor Neuronal Systems
J Pharmacol Exp Ther 2003 305: 434-439. Published online January 24, 2003; 10.1124/jpet.102.045419 [Abstract] [Full Text] [PDF]  

Michel Bottlaender, Frédéric Dollé, Ilonka Guenther, Dimitri Roumenov, Chantal Fuseau, Yann Bramoulle, Olivier Curet, Jamir Jegham, Jean-Louis Pinquier, Pascal George, and Heric Valette

Mapping the Cerebral Monoamine Oxidase Type A: Positron Emission Tomography Characterization of the Reversible Selective Inhibitor [¹¹C]Befloxatone
J Pharmacol Exp Ther 2003 305: 467-473. Published online February 11, 2003; 10.1124/jpet.102.046953 [Abstract] [Full Text] [PDF]  

Makoto Inoue, Toshiko Kawashima, Hiroshi Takeshima, Girolamo Calo, Atsuko Inoue, Yoshihiro Nakata, and Hiroshi Ueda

In Vivo Pain-Inhibitory Role of Nociceptin/Orphanin FQ in Spinal Cord
J Pharmacol Exp Ther 2003 305: 495-501. Published online January 24, 2003; 10.1124/jpet.102.046326 [Abstract] [Full Text] [PDF]  

Xue Qing Wang, Ai Ying Xiao, Aizhen Yang, Lori LaRose, Ling Wei, and Shan Ping Yu

Block of Na⁺,K⁺-ATPase and Induction of Hybrid Death by 4-Aminopyridine in Cultured Cortical Neurons
J Pharmacol Exp Ther 2003 305: 502-506. Published online January 21, 2003; 10.1124/jpet.102.045013 [Abstract] [Full Text] [PDF]  

Regina P. Markus, Jussara M. Santos, Wagner Zago, and Lívia A. C. Renó

Melatonin Nocturnal Surge Modulates Nicotinic Receptors and Nicotine-Induced [³H]Glutamate Release in Rat Cerebellum Slices
J Pharmacol Exp Ther 2003 305: 525-530. Published online January 24, 2003; 10.1124/jpet.102.045625 [Abstract] [Full Text] [PDF]  

Yu Zhao, Han-Ting Zhang, and James M. O'Donnell

Inhibitor Binding to Type 4 Phosphodiesterase (PDE4) Assessed Using [³H]Piclamilast and [³H]Rolipram
J Pharmacol Exp Ther 2003 305: 565-572. Published online January 24, 2003; 10.1124/jpet.102.047407 [Abstract] [Full Text] [PDF]  

J. E. Kralic, M. Wheeler, K. Renzi, C. Ferguson, T. K. O'Buckley, A. C. Grobin, A. L. Morrow, and G. E. Homanics

Deletion of GABA_A Receptor 1 Subunit-containing Receptors Alters Responses to Ethanol and Other Anesthetics
J Pharmacol Exp Ther 2003 305: 600-607. Published online February 11, 2003; 10.1124/jpet.102.048124 [Abstract] [Full Text] [PDF]  

Shitij Kapur, Susan C. VanderSpek, Barbara A. Brownlee, and José N. Nobrega

Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Condition: A Suggested Solution Based on in Vivo Occupancy
J Pharmacol Exp Ther 2003 305: 625-631. Published online February 20, 2003; 10.1124/jpet.102.046987 [Abstract] [Full Text] [PDF] Erratum  

Michael T. Flink and William D. Atchison

Iberiotoxin-Induced Block of Ca²⁺-Activated K⁺ Channels Induces Dihydropyridine Sensitivity of ACh Release from Mammalian Motor Nerve Terminals
J Pharmacol Exp Ther 2003 305: 646-652. Published online January 24, 2003; 10.1124/jpet.102.046102 [Abstract] [Full Text] [PDF]  

Natalie R. Lenard, Thomas W. Gettys, and Adrian J. Dunn

Activation of ₂- and ₃-Adrenergic Receptors Increases Brain Tryptophan
J Pharmacol Exp Ther 2003 305: 653-659. Published online January 24, 2003; 10.1124/jpet.102.048249 [Abstract] [Full Text] [PDF]  

Wei-Xing Shi and Xue-Xiang Zhang

Dendritic Glutamate-Induced Bursting in the Prefrontal Cortex: Further Characterization and Effects of Phencyclidine
J Pharmacol Exp Ther 2003 305: 680-687. Published online January 24, 2003; 10.1124/jpet.102.046359 [Abstract] [Full Text] [PDF]  

Hazel H. Szeto, Yi Soong, Dunli Wu, XuanXuan Qian, and Guo-Min Zhao

Endogenous Opioid Peptides Contribute to Antinociceptive Potency of Intrathecal [Dmt¹]DALDA
J Pharmacol Exp Ther 2003 305: 696-702. Published online January 24, 2003; 10.1124/jpet.102.048561 [Abstract] [Full Text] [PDF]  

Sonya G. Wilson, Camron D. Bryant, William R. Lariviere, Michael S. Olsen, Belinda E. Giles, Elissa J. Chesler, and Jeffrey S. Mogil

The Heritability of Antinociception II: Pharmacogenetic Mediation of Three Over-the-Counter Analgesics in Mice
J Pharmacol Exp Ther 2003 305: 755-764. Published online February 20, 2003; 10.1124/jpet.102.047902 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "₄₇/₄₁ Dual Integrin Antagonists Block ₄₇-Dependent Adhesion under Shear Flow"
J Pharmacol Exp Ther 2003 305: 796. [Full Text] [PDF]  

Correction to "Up-Regulation of Regulator of G Protein Signaling 4 Expression in a Model of Neuropathic Pain and Insensitivity to Morphine"
J Pharmacol Exp Ther 2003 305: 797. [Full Text] [PDF]  

Correction to "Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance Protein 1 (MRP1)"
J Pharmacol Exp Ther 2003 305: 798. [Full Text] [PDF]  

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