PERSPECTIVES IN PHARMACOLOGY:

J. D. Salamone, M. Correa, S. Mingote, and S. M. Weber

Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse
J Pharmacol Exp Ther 2003 305: 1-8. Published online January 21, 2003; 10.1124/jpet.102.035063 [Abstract] [Full Text] [PDF]  

Aaron J. Marcus, M. Johan Broekman, Joan H. F. Drosopoulos, Naziba Islam, David J. Pinsky, Casilde Sesti, and Roberto Levi

Metabolic Control of Excessive Extracellular Nucleotide Accumulation by CD39/Ecto-Nucleotidase-1: Implications for Ischemic Vascular Diseases
J Pharmacol Exp Ther 2003 305: 9-16. Published online January 21, 2003; 10.1124/jpet.102.043729 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Hidekazu Toyobuku, Yoshimichi Sai, Toru Kagami, Ikumi Tamai, and Akira Tsuji

Delivery of Peptide Drugs to the Brain by Adenovirus-Mediated Heterologous Expression of Human Oligopeptide Transporter at the Blood-Brain Barrier
J Pharmacol Exp Ther 2003 305: 40-47. Published online January 21, 2003; 10.1124/jpet.102.046243 [Abstract] [Full Text] [PDF]  

Brendan M. Johnson, Weiqing Chen, Ronald T. Borchardt, William N. Charman, and Christopher J. H. Porter

A Kinetic Evaluation of the Absorption, Efflux, and Metabolism of Verapamil in the Autoperfused Rat Jejunum
J Pharmacol Exp Ther 2003 305: 151-158. Published online January 21, 2003; 10.1124/jpet.102.045328 [Abstract] [Full Text] [PDF]  

Chunze Li, Mark P. Grillo, and Leslie Z. Benet

In Vivo Mechanistic Studies on the Metabolic Activation of 2-Phenylpropionic Acid in Rat
J Pharmacol Exp Ther 2003 305: 250-256. Published online January 21, 2003; 10.1124/jpet.102.043174 [Abstract] [Full Text] [PDF]  

Andreas J. Schwab, Lei Tao, Manjinder Kang, Lingjie Meng, and K. Sandy Pang

Moment Analysis of Metabolic Heterogeneity: Conjugation of Benzoate with Glycine in Rat Liver Studied by Multiple Indicator Dilution Technique
J Pharmacol Exp Ther 2003 305: 279-289. Published online January 21, 2003; 10.1124/jpet.102.044024 [Abstract] [Full Text] [PDF]  

Carolyn L. Cummins, Laurent Salphati, Michael J. Reid, and Leslie Z. Benet

In Vivo Modulation of Intestinal CYP3A Metabolism by P-Glycoprotein: Studies Using the Rat Single-Pass Intestinal Perfusion Model
J Pharmacol Exp Ther 2003 305: 306-314. Published online January 21, 2003; 10.1124/jpet.102.044719 [Abstract] [Full Text] [PDF]  

Sang K. Kim, Kimberley J. Woodcroft, and Raymond F. Novak

Insulin and Glucagon Regulation of Glutathione S-Transferase Expression in Primary Cultured Rat Hepatocytes
J Pharmacol Exp Ther 2003 305: 353-361. Published online January 21, 2003; 10.1124/jpet.102.045153 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

M. C. Holden Ko, Heeseung Lee, Michael S. Song, Katarzyna Sobczyk-Kojiro, Henry I. Mosberg, Shiroh Kishioka, James H. Woods, and Norah N. Naughton

Activation of -Opioid Receptors Inhibits Pruritus Evoked by Subcutaneous or Intrathecal Administration of Morphine in Monkeys
J Pharmacol Exp Ther 2003 305: 173-179. Published online January 21, 2003; 10.1124/jpet.102.044909 [Abstract] [Full Text] [PDF]  

Stephen D. Mague, Andrea M. Pliakas, Mark S. Todtenkopf, Hilarie C. Tomasiewicz, Yan Zhang, William C. Stevens, Jr., Robert M. Jones, Philip S. Portoghese, and William A. Carlezon, Jr.

Antidepressant-Like Effects of -Opioid Receptor Antagonists in the Forced Swim Test in Rats
J Pharmacol Exp Ther 2003 305: 323-330. Published online January 21, 2003; 10.1124/jpet.102.046433 [Abstract] [Full Text] [PDF]  

Andrea C. Nicholas and Lewis S. Seiden

Ambient Temperature Influences Core Body Temperature Response in Rat Lines Bred for Differences in Sensitivity to 8-Hydroxy-dipropylaminotetralin
J Pharmacol Exp Ther 2003 305: 368-374. Published online January 21, 2003; 10.1124/jpet.102.045088 [Abstract] [Full Text] [PDF]  

Koki Inoue, Glenn R. Valdez, Teresa M. Reyes, Lindsay E. Reinhardt, Antoine Tabarin, Jean Rivier, Wylie W. Vale, Paul E. Sawchenko, George F. Koob, and Eric P. Zorrilla

Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat
J Pharmacol Exp Ther 2003 305: 385-393. Published online January 21, 2003; 10.1124/jpet.102.047712 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Shinji Takai, Denan Jin, Masato Sakaguchi, Satoru Katayama, Michiko Muramatsu, Minoru Sakaguchi, Eiko Matsumura, Shokei Kim, and Mizuo Miyazaki

A Novel Chymase Inhibitor, 4-[1-{[bis-(4-Methyl-phenyl)-methyl]-carbamoyl}-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), Suppressed Cardiac Fibrosis in Cardiomyopathic Hamsters
J Pharmacol Exp Ther 2003 305: 17-23. Published online January 21, 2003; 10.1124/jpet.102.045179 [Abstract] [Full Text] [PDF]  

Charles-Edouard Luyt, Anne Meddahi-Pellé, Benoit Ho-Tin-Noe, Sylvia Colliec-Jouault, Jean Guezennec, Liliane Louedec, Hervé Prats, Marie-Paule Jacob, Mary Osborne-Pellegrin, Didier Letourneur, and Jean-Baptiste Michel

Low-Molecular-Weight Fucoidan Promotes Therapeutic Revascularization in a Rat Model of Critical Hindlimb Ischemia
J Pharmacol Exp Ther 2003 305: 24-30. Published online January 21, 2003; 10.1124/jpet.102.046144 [Abstract] [Full Text] [PDF]  

Toshiyuki Maki, Yoshihisa Nasa, Kouichi Tanonaka, Masaya Takahashi, and Satoshi Takeo

Beneficial Effects of Sampatrilat, a Novel Vasopeptidase Inhibitor, on Cardiac Remodeling and Function of Rats with Chronic Heart Failure following Left Coronary Artery Ligation
J Pharmacol Exp Ther 2003 305: 97-105. Published online November 25, 2002; 10.1124/jpet.102.042747 [Abstract] [Full Text] [PDF]  

S. Dhein, A. Kabat, A. Olbrich, P. Rösen, H. Schröder, and F.-W. Mohr

Effect of Chronic Treatment with Vitamin E on Endothelial Dysfunction in a Type I in Vivo Diabetes Mellitus Model and in Vitro
J Pharmacol Exp Ther 2003 305: 114-122. Published online January 21, 2003; 10.1124/jpet.102.045740 [Abstract] [Full Text] [PDF]  

Heather Fraser, Zhenhai Gao, Mark J. Ozeck, and Luiz Belardinelli

N-[3-(R)-Tetrahydrofuranyl]-6-aminopurine Riboside, an A₁ Adenosine Receptor Agonist, Antagonizes Catecholamine-Induced Lipolysis without Cardiovascular Effects in Awake Rats
J Pharmacol Exp Ther 2003 305: 225-231. Published online January 21, 2003; 10.1124/jpet.102.046821 [Abstract] [Full Text] [PDF]  

Paulus Kirchhof, Hubertus Degen, Michael R. Franz, Lars Eckardt, Larissa Fabritz, Peter Milberg, Stephanie Läer, Joachim Neumann, Günter Breithardt, and Wilhelm Haverkamp

Amiodarone-Induced Postrepolarization Refractoriness Suppresses Induction of Ventricular Fibrillation
J Pharmacol Exp Ther 2003 305: 257-263. Published online January 21, 2003; 10.1124/jpet.102.046755 [Abstract] [Full Text] [PDF]  

Gwenn Coatmellec-Taglioni, Jean-Pierre Dausse, Yves Giudicelli, and Catherine Ribière

Sexual Dimorphism in Cafeteria Diet-Induced Hypertension Is Associated with Gender-Related Difference in Renal Leptin Receptor Down-Regulation
J Pharmacol Exp Ther 2003 305: 362-367. Published online January 21, 2003; 10.1124/jpet.102.045682 [Abstract] [Full Text] [PDF]  

Bhagavatula Moorthy, Kimberly P. Miller, Weiwu Jiang, E. Spencer Williams, Sudha R. Kondraganti, and Kenneth S. Ramos

Role of Cytochrome P4501B1 in Benzo[a]pyrene Bioactivation to DNA-Binding Metabolites in Mouse Vascular Smooth Muscle Cells: Evidence from ³²P-Postlabeling for Formation of 3-Hydroxybenzo[a]pyrene and Benzo[a]pyrene-3,6-quinone as Major Proximate Genotoxic Intermediates
J Pharmacol Exp Ther 2003 305: 394-401. Published online January 21, 2003; 10.1124/jpet.102.044271 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Bo Rum Ryu, Young Ae Lee, Seok Joon Won, Ji-Hyun Noh, Su-Youne Chang, Jun-Mo Chung, Jun Sub Choi, Choun Ki Joo, Sung Hwa Yoon, and Byoung Joo Gwag

The Novel Neuroprotective Action of Sulfasalazine through Blockade of NMDA Receptors
J Pharmacol Exp Ther 2003 305: 48-56. Published online January 21, 2003; 10.1124/jpet.102.042606 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Dawn E. W. Livingstone and Brian R. Walker

Is 11-Hydroxysteroid Dehydrogenase Type 1 a Therapeutic Target? Effects of Carbenoxolone in Lean and Obese Zucker Rats
J Pharmacol Exp Ther 2003 305: 167-172. Published online January 21, 2003; 10.1124/jpet.102.044842 [Abstract] [Full Text] [PDF]  

Joohyung Lee, Tomris Mustafa, Sharon G. McDowall, Frederick A. O. Mendelsohn, Michelle Brennan, Rebecca A. Lew, Anthony L. Albiston, and Siew Yeen Chai

Structure-Activity Study of LVV-Hemorphin-7: Angiotensin AT₄ Receptor Ligand and Inhibitor of Insulin-Regulated Aminopeptidase
J Pharmacol Exp Ther 2003 305: 205-211. Published online November 25, 2002; 10.1124/jpet.102.045492 [Abstract] [Full Text] [PDF]  

Guohong Liu, Nejmi Dilmac, Nathan Hilliard, and Gregory H. Hockerman

Ca_v1.3 Is Preferentially Coupled to Glucose-Stimulated Insulin Secretion in the Pancreatic -Cell Line INS-1
J Pharmacol Exp Ther 2003 305: 271-278. Published online January 21, 2003; 10.1124/jpet.102.046334 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Makoto Sasaki, Sulaiman Bharwani, Paul Jordan, Takashi Joh, Kenneth Manas, April Warren, Hirohisa Harada, Patsy Carter, John W. Elrod, Michael Wolcott, Matthew B. Grisham, and J. Steven Alexander

The 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitor Pravastatin Reduces Disease Activity and Inflammation in Dextran-Sulfate Induced Colitis
J Pharmacol Exp Ther 2003 305: 78-85. Published online January 21, 2003; 10.1124/jpet.102.044099 [Abstract] [Full Text] [PDF]  

Minoru Matsui, Michael T. Griffin, Darakhshanda Shehnaz, Makoto M. Taketo, and Frederick J. Ehlert

Increased Relaxant Action of Forskolin and Isoproterenol against Muscarinic Agonist-Induced Contractions in Smooth Muscle from M₂ Receptor Knockout Mice
J Pharmacol Exp Ther 2003 305: 106-113. Published online January 21, 2003; 10.1124/jpet.102.044701 [Abstract] [Full Text] [PDF]  

Mohamed H. Ahmed, Nick Ashton, and Richard J. Balment

Renal Function in a Rat Model of Analgesic Nephropathy: Effect of Chloroquine
J Pharmacol Exp Ther 2003 305: 123-130. Published online January 21, 2003; 10.1124/jpet.102.047233 [Abstract] [Full Text] [PDF]  

Jana Neumann and Matthias Brandsch

-Aminolevulinic Acid Transport in Cancer Cells of the Human Extrahepatic Biliary Duct
J Pharmacol Exp Ther 2003 305: 219-224. Published online January 21, 2003; 10.1124/jpet.102.046573 [Abstract] [Full Text] [PDF]  

Keita Uehara, Soichiro Miura, Tetsu Takeuchi, Takao Taki, Manabu Nakashita, Masayuki Adachi, Toshiaki Inamura, Toshiko Ogawa, Yasutada Akiba, Hidekazu Suzuki, Hiroshi Nagata, and Hiromasa Ishii

Significant Role of Ceramide Pathway in Experimental Gastric Ulcer Formation in Rats
J Pharmacol Exp Ther 2003 305: 232-239. Published online January 21, 2003; 10.1124/jpet.102.045195 [Abstract] [Full Text] [PDF]  

Tomoko Takano, Andrey V. Cybulsky, William A. Cupples, David O. Ajikobi, Joan Papillon, and Lamine Aoudjit

Inhibition of Cyclooxygenases Reduces Complement-Induced Glomerular Epithelial Cell Injury and Proteinuria in Passive Heymann Nephritis
J Pharmacol Exp Ther 2003 305: 240-249. Published online January 21, 2003; 10.1124/jpet.102.043604 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Renate Bang, Gabriele Sass, Alexandra K. Kiemer, Angelika M. Vollmar, Winfried L. Neuhuber, and Gisa Tiegs

Neurokinin-1 Receptor Antagonists CP-96,345 and L-733,060 Protect Mice from Cytokine-Mediated Liver Injury
J Pharmacol Exp Ther 2003 305: 31-39. Published online January 21, 2003; 10.1124/jpet.102.043539 [Abstract] [Full Text] [PDF]  

Masayuki Fujino, Naoko Funeshima, Yusuke Kitazawa, Hiromitsu Kimura, Hiroshi Amemiya, Seiichi Suzuki, and Xiao-Kang Li

Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment
J Pharmacol Exp Ther 2003 305: 70-77. Published online January 21, 2003; 10.1124/jpet.102.045658 [Abstract] [Full Text] [PDF]  

Mehtap Yuksel, Kenji Okajima, Mitsuhiro Uchiba, and Hiroaki Okabe

Gabexate Mesilate, a Synthetic Protease Inhibitor, Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor- Production by Inhibiting Activation of Both Nuclear Factor-B and Activator Protein-1 in Human Monocytes
J Pharmacol Exp Ther 2003 305: 298-305. Published online January 21, 2003; 10.1124/jpet.102.041988 [Abstract] [Full Text] [PDF]  

Shirley K. Lu, Shellie M. Callahan, and Lane J. Brunner

Suppression of Hepatic CYP3A1/2 and CYP2C11 by Cyclosporine Is Not Mediated by Altering Growth Hormone Levels
J Pharmacol Exp Ther 2003 305: 331-337. Published online January 21, 2003; 10.1124/jpet.102.044776 [Abstract] [Full Text] [PDF]  

Hiromi Sugimoto, Michitaka Shichijo, Takashi Iino, Yoshihisa Manabe, Akihiko Watanabe, Makoto Shimazaki, Florian Gantner, and Kevin B. Bacon

An Orally Bioavailable Small Molecule Antagonist of CRTH2, Ramatroban (BAY u3405), Inhibits Prostaglandin D₂-Induced Eosinophil Migration in Vitro
J Pharmacol Exp Ther 2003 305: 347-352. Published online January 21, 2003; 10.1124/jpet.102.046748 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Ge Zhang, Ning Huang, Yu-Wen Li, Xiaoping Qi, Anne P. Marshall, Xiao-Xin Yan, Geraldine Hill, Cynthia Rominger, Shimoga R. Prakash, Rajagopal Bakthavatchalam, David H. Rominger, Paul J. Gilligan, and Robert Zaczek

Pharmacological Characterization of a Novel Nonpeptide Antagonist Radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([³H]SN003) for Corticotropin-Releasing Factor₁ Receptors
J Pharmacol Exp Ther 2003 305: 57-69. Published online January 21, 2003; 10.1124/jpet.102.046128 [Abstract] [Full Text] [PDF]  

Yu-Wen Li, Geraldine Hill, Harvey Wong, Natasha Kelly, Kathryn Ward, Marie Pierdomenico, Shelly Ren, Paul Gilligan, Scott Grossman, George Trainor, Rebecca Taub, John McElroy, and Robert Zazcek

Receptor Occupancy of Nonpeptide Corticotropin-Releasing Factor 1 Antagonist DMP696: Correlation with Drug Exposure and Anxiolytic Efficacy
J Pharmacol Exp Ther 2003 305: 86-96. Published online January 21, 2003; 10.1124/jpet.102.045914 [Abstract] [Full Text] [PDF]  

Qi Shi, Jason E. Savage, Sandra J. Hufeisen, Laura Rauser, Ewa Grajkowska, Paul Ernsberger, Jarda T. Wroblewski, Joseph H. Nadeau, and Bryan L. Roth

L-Homocysteine Sulfinic Acid and Other Acidic Homocysteine Derivatives Are Potent and Selective Metabotropic Glutamate Receptor Agonists
J Pharmacol Exp Ther 2003 305: 131-142. Published online January 21, 2003; 10.1124/jpet.102.047092 [Abstract] [Full Text] [PDF]  

Alan P. Kozikowski, Kenneth M. Johnson, Olivier Deschaux, Bidhan C. Bandyopadhyay, Gian Luca Araldi, Gilberto Carmona, Patrik Munzar, Miles P. Smith, Robert L. Balster, Patrick M. Beardsley, and Srihari R. Tella

Mixed Cocaine Agonist/Antagonist Properties of (+)-Methyl 4-(4-Chlorophenyl)-1-methylpiperidine-3-carboxylate, a Piperidine-Based Analog of Cocaine
J Pharmacol Exp Ther 2003 305: 143-150. Published online January 21, 2003; 10.1124/jpet.102.046318 [Abstract] [Full Text] [PDF]  

Jilla Sabeti, Greg A. Gerhardt, and Nancy R. Zahniser

Individual Differences in Cocaine-Induced Locomotor Sensitization in Low and High Cocaine Locomotor-Responding Rats Are Associated with Differential Inhibition of Dopamine Clearance in Nucleus Accumbens
J Pharmacol Exp Ther 2003 305: 180-190. Published online January 21, 2003; 10.1124/jpet.102.047258 [Abstract] [Full Text] [PDF]  

S. A. Sands, K. E. McCarson, and S. J. Enna

Differential Regulation of GABA_B Receptor Subunit Expression and Function
J Pharmacol Exp Ther 2003 305: 191-196. Published online January 21, 2003; 10.1124/jpet.102.046342 [Abstract] [Full Text] [PDF]  

Johanna Weiss, Sven-Maria Gregor Dormann, Meret Martin-Facklam, Christian Johannes Kerpen, Nahal Ketabi-Kiyanvash, and Walter Emil Haefeli

Inhibition of P-Glycoprotein by Newer Antidepressants
J Pharmacol Exp Ther 2003 305: 197-204. Published online January 21, 2003; 10.1124/jpet.102.046532 [Abstract] [Full Text] [PDF]  

Yuxin Liu, Liya Qin, Guorong Li, Wei Zhang, Lijia An, Bin Liu, and Jau-Shyong Hong

Dextromethorphan Protects Dopaminergic Neurons against Inflammation-Mediated Degeneration through Inhibition of Microglial Activation
J Pharmacol Exp Ther 2003 305: 212-218. Published online January 21, 2003; 10.1124/jpet.102.043166 [Abstract] [Full Text] [PDF]  

W. R. Proctor, W. Poelchen, Barbara J. Bowers, Jeanne M. Wehner, R. O. Messing, and T. V. Dunwiddie

Ethanol Differentially Enhances Hippocampal GABA_A Receptor-Mediated Responses in Protein Kinase C (PKC) and PKC Null Mice
J Pharmacol Exp Ther 2003 305: 264-270. Published online January 21, 2003; 10.1124/jpet.102.045450 [Abstract] [Full Text] [PDF]  

Albert H. Avila, Camille A. Morgan, and Barbara M. Bayer

Stress-Induced Suppression of the Immune System after Withdrawal from Chronic Cocaine
J Pharmacol Exp Ther 2003 305: 290-297. Published online January 21, 2003; 10.1124/jpet.102.045989 [Abstract] [Full Text] [PDF]  

Ai-Ming Yu, Jeffrey R. Idle, Kristopher W. Krausz, Adrian Küpfer, and Frank J. Gonzalez

Contribution of Individual Cytochrome P450 Isozymes to the O-Demethylation of the Psychotropic -Carboline Alkaloids Harmaline and Harmine
J Pharmacol Exp Ther 2003 305: 315-322. Published online January 21, 2003; 10.1124/jpet.102.047050 [Abstract] [Full Text] [PDF]  

A. Gobert, B. Di Cara, L. Cistarelli, and M. J. Millan

Piribedil Enhances Frontocortical and Hippocampal Release of Acetylcholine in Freely Moving Rats by Blockade of _2A-Adrenoceptors: A Dialysis Comparison to Talipexole and Quinelorane in the Absence of Acetylcholinesterase Inhibitors
J Pharmacol Exp Ther 2003 305: 338-346. Published online January 21, 2003; 10.1124/jpet.102.046383 [Abstract] [Full Text] [PDF]  

A. V. Terry, Jr., J. D. Stone, J. J. Buccafusco, D. W. Sickles, A. Sood, and M. A. Prendergast

Repeated Exposures to Subthreshold Doses of Chlorpyrifos in Rats: Hippocampal Damage, Impaired Axonal Transport, and Deficits in Spatial Learning
J Pharmacol Exp Ther 2003 305: 375-384. Published online January 21, 2003; 10.1124/jpet.102.041897 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Jon E. Sprague, Matthew L. Banks, Valerie J. Cook, and Edward M. Mills

Hypothalamic-Pituitary-Thyroid Axis and Sympathetic Nervous System Involvement in Hyperthermia Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy)
J Pharmacol Exp Ther 2003 305: 159-166. Published online January 21, 2003; 10.1124/jpet.102.044982 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates"
J Pharmacol Exp Ther 2003 305: 402. [Full Text] [PDF]  

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