PERSPECTIVES IN PHARMACOLOGY:

Mary L. Michaelis

Drugs Targeting Alzheimer's Disease: Some Things Old and Some Things New
J Pharmacol Exp Ther 2003 304: 897-904. Published online November 25, 2002; 10.1124/jpet.102.035840 [Abstract] [Full Text] [PDF]  

Paul A. Nony and Rick G. Schnellmann

Mechanisms of Renal Cell Repair and Regeneration after Acute Renal Failure
J Pharmacol Exp Ther 2003 304: 905-912. Published online November 25, 2002; 10.1124/jpet.102.035022 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Jukka Hakkola, Yin Hu, and Magnus Ingelman-Sundberg

Mechanisms of Down-Regulation of CYP2E1 Expression by Inflammatory Cytokines in Rat Hepatoma Cells
J Pharmacol Exp Ther 2003 304: 1048-1054. [Abstract] [Full Text] [PDF]  

HaiQing Dai, Peter Marbach, Michel Lemaire, Michael Hayes, and William F. Elmquist

Distribution of STI-571 to the Brain Is Limited by P-Glycoprotein-Mediated Efflux
J Pharmacol Exp Ther 2003 304: 1085-1092. Published online December 13, 2002; 10.1124/jpet.102.045260 [Abstract] [Full Text] [PDF]  

Sanjeev Kumar, Gloria Y. Kwei, Grace K. Poon, Susan A. Iliff, Yanfeng Wang, Qing Chen, Ronald B. Franklin, Varsha Didolkar, Regina W. Wang, Masayo Yamazaki, Shuet-Hing Lee Chiu, Jiunn H. Lin, Paul G. Pearson, and Thomas A. Baillie

Pharmacokinetics and Interactions of a Novel Antagonist of Chemokine Receptor 5 (CCR5) with Ritonavir in Rats and Monkeys: Role of CYP3A and P-Glycoprotein
J Pharmacol Exp Ther 2003 304: 1161-1171. Published online November 25, 2002; 10.1124/jpet.102.045096 [Abstract] [Full Text] [PDF]  

Jun Chen, Huimin Lin, and Ming Hu

Metabolism of Flavonoids via Enteric Recycling: Role of Intestinal Disposition
J Pharmacol Exp Ther 2003 304: 1228-1235. Published online December 13, 2002; 10.1124/jpet.102.046409 [Abstract] [Full Text] [PDF]  

Shuzhong Zhang and Marilyn E. Morris

Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport
J Pharmacol Exp Ther 2003 304: 1258-1267. Published online December 13, 2002; 10.1124/jpet.102.044412 [Abstract] [Full Text] [PDF]  

David D. Allen, Paul R. Lockman, Karen E. Roder, Linda P. Dwoskin, and Peter A. Crooks

Active Transport of High-Affinity Choline and Nicotine Analogs into the Central Nervous System by the Blood-Brain Barrier Choline Transporter
J Pharmacol Exp Ther 2003 304: 1268-1274. Published online December 13, 2002; 10.1124/jpet.102.045856 [Abstract] [Full Text] [PDF]  

Donghua Yin, Huiping Xu, Yali He, Leonid I. Kirkovsky, Duane D. Miller, and James T. Dalton

Pharmacology, Pharmacokinetics, and Metabolism of Acetothiolutamide, a Novel Nonsteroidal Agonist for the Androgen Receptor
J Pharmacol Exp Ther 2003 304: 1323-1333. Published online December 13, 2002; 10.1124/jpet.102.040832 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Stephen G. Holtzman

Discrimination of a Single Dose of Morphine Followed by Naltrexone: Substitution of Other Agonists for Morphine and Other Antagonists for Naltrexone in a Rat Model of Acute Dependence
J Pharmacol Exp Ther 2003 304: 1033-1041. Published online November 25, 2002; 10.1124/jpet.102.044875 [Abstract] [Full Text] [PDF]  

T. J. Hudzik, M. Yanek, T. Porrey, J. Evenden, C. Paronis, M. Mastrangelo, C. Ryan, S. Ross, and C. Stenfors

Behavioral Pharmacology of AR-A000002, a Novel, Selective 5-Hydroxytryptamine_1B Antagonist
J Pharmacol Exp Ther 2003 304: 1072-1084. Published online November 25, 2002; 10.1124/jpet.102.045468 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Reginald Liew, J. Koudy Williams, Peter Collins, and Kenneth T. MacLeod

Soy-Derived Isoflavones Exert Opposing Actions on Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 2003 304: 985-993. Published online November 25, 2002; 10.1124/jpet.102.042986 [Abstract] [Full Text] [PDF]  

Imène Tabbi-Anneni, Cécile Helies-Toussaint, Didier Morin, Anne Bescond-Jacquet, Arnaud Lucien, and Alain Grynberg

Prevention of Heart Failure in Rats by Trimetazidine Treatment: A Consequence of Accelerated Phospholipid Turnover?
J Pharmacol Exp Ther 2003 304: 1003-1009. Published online November 25, 2002; 10.1124/jpet.102.042143 [Abstract] [Full Text] [PDF]  

Walter Raasch, Britta Jungbluth, Ulrich Schäfer, Walter Häuser, and Peter Dominiak

Modification of Noradrenaline Release in Pithed Spontaneously Hypertensive Rats by I₁-Binding Sites in Addition to ₂-Adrenoceptors
J Pharmacol Exp Ther 2003 304: 1063-1071. Published online November 25, 2002; 10.1124/jpet.102.044966 [Abstract] [Full Text] [PDF]  

Koji Nobe, Yasushi Sakai, Hiromi Nobe, Junko Takashima, Richard J. Paul, and Kazutaka Momose

Enhancement Effect under High-Glucose Conditions on U46619-Induced Spontaneous Phasic Contraction in Mouse Portal Vein
J Pharmacol Exp Ther 2003 304: 1129-1142. Published online November 25, 2002; 10.1124/jpet.102.040964 [Abstract] [Full Text] [PDF]  

Eliana H. Akamine, Thomas C. Hohman, Dorothy Nigro, Maria Helena C. Carvalho, Rita de Cássia Tostes, and Zuleica B. Fortes

Minalrestat, an Aldose Reductase Inhibitor, Corrects the Impaired Microvascular Reactivity in Diabetes
J Pharmacol Exp Ther 2003 304: 1236-1242. Published online December 13, 2002; 10.1124/jpet.102.044693 [Abstract] [Full Text] [PDF]  

Y.-J. Chen, H. Jiang, and J. Quilley

The Nitric Oxide- and Prostaglandin-Independent Component of the Renal Vasodilator Effect of Thimerosal Is Mediated by Epoxyeicosatrienoic Acids
J Pharmacol Exp Ther 2003 304: 1292-1298. Published online November 25, 2002; 10.1124/jpet.102.042671 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Medora M. Hardy, Eric A. G. Blomme, Andrew Lisowski, Kevin S. Chinn, Amy Jones, Janet M. Harmon, Alan Opsahl, Richard L. Ornberg, and Catherine S. Tripp

Selective Cyclooxygenase-2 Inhibition Does Not Alter Keratinocyte Wound Responses in the Mouse Epidermis after Abrasion
J Pharmacol Exp Ther 2003 304: 959-967. Published online November 25, 2002; 10.1124/jpet.102.044545 [Abstract] [Full Text] [PDF]  

Yurii V. Mukhin, Evgeny A. Garnovsky, Michael E. Ullian, and Maria N. Garnovskaya

Bradykinin B₂ Receptor Activates Extracellular Signal-Regulated Protein Kinase in mIMCD-3 Cells via Epidermal Growth Factor Receptor Transactivation
J Pharmacol Exp Ther 2003 304: 968-977. Published online November 25, 2002; 10.1124/jpet.102.043943 [Abstract] [Full Text] [PDF]  

Hiroki Yokoo, Tomokazu Saitoh, Seiji Shiraishi, Toshihiko Yanagita, Takashi Sugano, Shin-Ichi Minami, Hideyuki Kobayashi, and Akihiko Wada

Distinct Effects of Ketone Bodies on Down-Regulation of Cell Surface Insulin Receptor and Insulin Receptor Substrate-1 Phosphorylation in Adrenal Chromaffin Cells
J Pharmacol Exp Ther 2003 304: 994-1002. Published online November 25, 2002; 10.1124/jpet.102.044115 [Abstract] [Full Text] [PDF]  

Motohiko Chachin, Mitsuhiko Yamada, Akikazu Fujita, Tetsuro Matsuoka, Kenji Matsushita, and Yoshihisa Kurachi

Nateglinide, a D-Phenylalanine Derivative Lacking Either a Sulfonylurea or Benzamido Moiety, Specifically Inhibits Pancreatic -Cell-Type K_ATP Channels
J Pharmacol Exp Ther 2003 304: 1025-1032. Published online November 25, 2002; 10.1124/jpet.102.044917 [Abstract] [Full Text] [PDF]  

Michel Frédérich, Mohamed Bentires-Alj, Monique Tits, Luc Angenot, Roland Greimers, Jacques Gielen, Vincent Bours, and Marie-Paule Merville

Isostrychnopentamine, an Indolomonoterpenic Alkaloid from Strychnos usambarensis, Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells
J Pharmacol Exp Ther 2003 304: 1103-1110. Published online November 25, 2002; 10.1124/jpet.102.044867 [Abstract] [Full Text] [PDF]  

Bahjat Al-Ani and Morley D. Hollenberg

Selective Tryptic Cleavage at the Tethered Ligand Site of the Amino Terminal Domain of Proteinase-Activated Receptor-2 in Intact Cells
J Pharmacol Exp Ther 2003 304: 1120-1128. Published online November 25, 2002; 10.1124/jpet.102.043844 [Abstract] [Full Text] [PDF]  

Yi Zuo, Jay Z. Yeh, and Toshio Narahashi

Dual Action of n-Butanol on Neuronal Nicotinic 42 Acetylcholine Receptors
J Pharmacol Exp Ther 2003 304: 1143-1152. Published online December 13, 2002; 10.1124/jpet.102.044537 [Abstract] [Full Text] [PDF]  

Ellen Niederberger, Irmgard Tegeder, Christine Schäfer, Maic Seegel, Sabine Grösch, and Gerd Geisslinger

Opposite Effects of Rofecoxib on Nuclear Factor-B and Activating Protein-1 Activation
J Pharmacol Exp Ther 2003 304: 1153-1160. Published online December 13, 2002; 10.1124/jpet.102.044016 [Abstract] [Full Text] [PDF]  

Nathalie Mercier, Marthe Moldes, Khadija El Hadri, and Bruno Fève

Regulation of Semicarbazide-Sensitive Amine Oxidase Expression by Tumor Necrosis Factor- in Adipocytes: Functional Consequences on Glucose Transport
J Pharmacol Exp Ther 2003 304: 1197-1208. Published online December 13, 2002; 10.1124/jpet.102.044420 [Abstract] [Full Text] [PDF]  

Sarah A. Nickolls, Mary I. Cismowski, Xiaochuan Wang, Meira Wolff, Paul J. Conlon, and Richard A. Maki

Molecular Determinants of Melanocortin 4 Receptor Ligand Binding and MC4/MC3 Receptor Selectivity
J Pharmacol Exp Ther 2003 304: 1217-1227. Published online November 25, 2002; 10.1124/jpet.102.044974 [Abstract] [Full Text] [PDF]  

Nabil Djouder, Eduardo Aneiros, Adolfo Cavalié, and Klaus Aktories

Effects of Large Clostridial Cytotoxins on Activation of RBL 2H3-hm1 Mast Cells Indicate Common and Different Roles of Rac in FcRI and M1-Receptor Signaling
J Pharmacol Exp Ther 2003 304: 1243-1250. Published online December 13, 2002; 10.1124/jpet.102.045351 [Abstract] [Full Text] [PDF]  

Martine Garnier, Paola F. Zaratin, Giovanna Ficalora, Maurizio Valente, Laura Fontanella, Man-Hee Rhee, Kendall J. Blumer, and Mark A. Scheideler

Up-Regulation of Regulator of G Protein Signaling 4 Expression in a Model of Neuropathic Pain and Insensitivity to Morphine
J Pharmacol Exp Ther 2003 304: 1299-1306. Published online November 25, 2002; 10.1124/jpet.102.043471 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Vijayakrishna K. Gadi, Sherrie D. Alexander, William R. Waud, Paula W. Allan, William B. Parker, and Eric J. Sorscher

A Long-Acting Suicide Gene Toxin, 6-Methylpurine, Inhibits Slow Growing Tumors after a Single Administration
J Pharmacol Exp Ther 2003 304: 1280-1284. Published online December 13, 2002; 10.1124/jpet.102.044743 [Abstract] [Full Text] [PDF]  

Hitoshi Someya, Sue C. Shaddix, Kamal N. Tiwari, John A. Secrist, III, and William B. Parker

Phosphorylation of 4'-thio--D-Arabinofuranosylcytosine and Its Analogs by Human Deoxycytidine Kinase
J Pharmacol Exp Ther 2003 304: 1314-1322. Published online December 13, 2002; 10.1124/jpet.102.045435 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Donghua Yin, Wenqing Gao, Jeffrey D. Kearbey, Huiping Xu, Kiwon Chung, Yali He, Craig A. Marhefka, Karen A. Veverka, Duane D. Miller, and James T. Dalton

Pharmacodynamics of Selective Androgen Receptor Modulators
J Pharmacol Exp Ther 2003 304: 1334-1340. Published online December 13, 2002; 10.1124/jpet.102.040840 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Koji Takeuchi, Shinichi Kato, Masanori Takeeda, Yoshihiro Ogawa, Masato Nakashima, and Masahiro Matsumoto

Facilitation by Endogenous Prostaglandins of Capsaicin-Induced Gastric Protection in Rodents through EP2 and IP Receptors
J Pharmacol Exp Ther 2003 304: 1055-1062. Published online November 25, 2002; 10.1124/jpet.102.044156 [Abstract] [Full Text] [PDF]  

Michael J. Carr, Marian Kollarik, Sonya N. Meeker, and Bradley J. Undem

A Role for TRPV1 in Bradykinin-Induced Excitation of Vagal Airway Afferent Nerve Terminals
J Pharmacol Exp Ther 2003 304: 1275-1279. Published online December 13, 2002; 10.1124/jpet.102.043422 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Vinay S. Bansal, Sanskruti Vaidya, Elizabeth P. Somers, Mansi Kanuga, Diane Shevell, Renee Weikel, and Patricia A. Detmers

Small Molecule Antagonists of Complement Receptor Type 3 Block Adhesion and Adhesion-Dependent Oxidative Burst in Human Polymorphonuclear Leukocytes
J Pharmacol Exp Ther 2003 304: 1016-1024. Published online November 25, 2002; 10.1124/jpet.102.045286 [Abstract] [Full Text] [PDF]  

Maureen Mullarkey, Jeffrey R. Rose, John Bristol, Tsutomu Kawata, Akufumi Kimura, Seiichi Kobayashi, Melinda Przetak, Jesse Chow, Fabian Gusovsky, William J. Christ, and Daniel P. Rossignol

Inhibition of Endotoxin Response by E5564, a Novel Toll-Like Receptor 4-Directed Endotoxin Antagonist
J Pharmacol Exp Ther 2003 304: 1093-1102. Published online November 25, 2002; 10.1124/jpet.102.044487 [Abstract] [Full Text] [PDF]  

Rut Lucas, Clelia Giannini, Maria Valeria D'auria, and Miguel Payá

Modulatory Effect of Bolinaquinone, a Marine Sesquiterpenoid, on Acute and Chronic Inflammatory Processes
J Pharmacol Exp Ther 2003 304: 1172-1180. Published online December 13, 2002; 10.1124/jpet.102.045278 [Abstract] [Full Text] [PDF]  

Mark A. Birrell, Kerryn McCluskie, El-Bdaoui Haddad, Cliff H. Battram, Stephen E. Webber, Martyn L. Foster, Magdi H. Yacoub, and Maria G. Belvisi

Pharmacological Assessment of the Nitric-Oxide Synthase Isoform Involved in Eosinophilic Inflammation in a Rat Model of Sephadex-Induced Airway Inflammation
J Pharmacol Exp Ther 2003 304: 1285-1291. Published online December 13, 2002; 10.1124/jpet.102.044339 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Lalitha Madhavan, William J. Freed, Vellareddy Anantharam, and Anumantha G. Kanthasamy

5-Hydroxytryptamine 1A Receptor Activation Protects against N-Methyl-D-aspartate-Induced Apoptotic Cell Death in Striatal and Mesencephalic Cultures
J Pharmacol Exp Ther 2003 304: 913-923. Published online November 25, 2002; 10.1124/jpet.102.044370 [Abstract] [Full Text] [PDF]  

Joost Pil and Jan Tytgat

Serine 329 of the µ-Opioid Receptor Interacts Differently with Agonists
J Pharmacol Exp Ther 2003 304: 924-930. Published online November 25, 2002; 10.1124/jpet.102.040113 [Abstract] [Full Text] [PDF]  

M. J. Gerdin, M. I. Masana, D. Ren, R. J. Miller, and M. L. Dubocovich

Short-Term Exposure to Melatonin Differentially Affects the Functional Sensitivity and Trafficking of the hMT₁ and hMT₂ Melatonin Receptors
J Pharmacol Exp Ther 2003 304: 931-939. Published online November 25, 2002; 10.1124/jpet.102.044990 [Abstract] [Full Text] [PDF]  

Md Harunor Rashid, Makoto Inoue, Saori Kondo, Toshiko Kawashima, Shiho Bakoshi, and Hiroshi Ueda

Novel Expression of Vanilloid Receptor 1 on Capsaicin-Insensitive Fibers Accounts for the Analgesic Effect of Capsaicin Cream in Neuropathic Pain
J Pharmacol Exp Ther 2003 304: 940-948. Published online December 13, 2002; 10.1124/jpet.102.046250 [Abstract] [Full Text] [PDF]  

Richard T. Robinson, Brandon C. Drafts, and Janet L. Fisher

Fluoxetine Increases GABA_A Receptor Activity through a Novel Modulatory Site
J Pharmacol Exp Ther 2003 304: 978-984. Published online November 25, 2002; 10.1124/jpet.102.044834 [Abstract] [Full Text] [PDF]  

Diana L. Cichewicz and Erin A. McCarthy

Antinociceptive Synergy between ⁹-Tetrahydrocannabinol and Opioids after Oral Administration
J Pharmacol Exp Ther 2003 304: 1010-1015. Published online November 25, 2002; 10.1124/jpet.102.045575 [Abstract] [Full Text] [PDF]  

Toshiyuki Sato, Yoshiyuki Morishima, and Yasufumi Shirasaki

3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e), a Novel Calmodulin Antagonist, Reduces Brain Edema through the Inhibition of Enhanced Blood-Brain Barrier Permeability after Transient Focal Ischemia
J Pharmacol Exp Ther 2003 304: 1042-1047. Published online November 25, 2002; 10.1124/jpet.102.045039 [Abstract] [Full Text] [PDF]  

Verónica Sandoval, Evan L. Riddle, Glen R. Hanson, and Annette E. Fleckenstein

Methylphenidate Alters Vesicular Monoamine Transport and Prevents Methamphetamine-Induced Dopaminergic Deficits
J Pharmacol Exp Ther 2003 304: 1181-1187. Published online December 13, 2002; 10.1124/jpet.102.045005 [Abstract] [Full Text] [PDF]  

Robert I. Westphalen and Hugh C. Hemmings, Jr.

Selective Depression by General Anesthetics of Glutamate Versus GABA Release from Isolated Cortical Nerve Terminals
J Pharmacol Exp Ther 2003 304: 1188-1196. Published online December 13, 2002; 10.1124/jpet.102.044685 [Abstract] [Full Text] [PDF]  

K. J. Damjanoska, N. A. Muma, Y. Zhang, D. N. D'Souza, F. Garcia, G. A. Carrasco, G. H. Kindel, K. A. Haskins, M. Shankaran, B. R. Petersen, and L. D. Van De Kar

Neuroendocrine Evidence That (S)-2-(Chloro-5-fluoro-indol- l-yl)-1-methylethylamine Fumarate (Ro 60-0175) Is Not a Selective 5-Hydroxytryptamine_2C Receptor Agonist
J Pharmacol Exp Ther 2003 304: 1209-1216. Published online December 13, 2002; 10.1124/jpet.102.043489 [Abstract] [Full Text] [PDF]  

S. A. G. Visser, F. L. C. Wolters, P. H. van der Graaf, L. A. Peletier, and M. Danhof

Dose-Dependent EEG Effects of Zolpidem Provide Evidence for GABA_A Receptor Subtype Selectivity in Vivo
J Pharmacol Exp Ther 2003 304: 1251-1257. Published online December 13, 2002; 10.1124/jpet.102.044859 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Tobi L. Limke, James K. L. Otero-Montañez, and William D. Atchison

Evidence for Interactions between Intracellular Calcium Stores during Methylmercury-Induced Intracellular Calcium Dysregulation in Rat Cerebellar Granule Neurons
J Pharmacol Exp Ther 2003 304: 949-958. [Abstract] [Full Text] [PDF]  

Oscar U. Scremin, Tsung-Ming Shih, Ly Huynh, Margareth Roch, Ruth Booth, and Donald J. Jenden

Delayed Neurologic and Behavioral Effects of Subtoxic Doses of Cholinesterase Inhibitors
J Pharmacol Exp Ther 2003 304: 1111-1119. Published online November 25, 2002; 10.1124/jpet.102.044818 [Abstract] [Full Text] [PDF]  

Tjerk J. H. Bueters, Marloes J. A. Joosen, Herman P. M. van Helden, Ad P. IJzerman, and Meindert Danhof

Adenosine A₁ Receptor Agonist N⁶-Cyclopentyladenosine Affects the Inactivation of Acetylcholinesterase in Blood and Brain by Sarin
J Pharmacol Exp Ther 2003 304: 1307-1313. Published online December 13, 2002; 10.1124/jpet.102.044644 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Influence of Ovarian Sex Steroids on Spinal Methionine-Enkephalin Release: Comparison with Dynorphin Reveals Asymmetrical Regulation"
J Pharmacol Exp Ther 2003 304: 1341. [Full Text] [PDF]  

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