PERSPECTIVES IN PHARMACOLOGY:

Bin Liu and Jau-Shyong Hong

Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention
J Pharmacol Exp Ther 2003 304: 1-7. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Saeed Taheri, Lawrence P. Cogswell, III, Alison Gent, and Gary R. Strichartz

Hydrophobic and Ionic Factors in the Binding of Local Anesthetics to the Major Variant of Human ₁-Acid Glycoprotein
J Pharmacol Exp Ther 2003 304: 71-80. [Abstract] [Full Text] [PDF]  

Renee J. Krause, Lawrence H. Lash, and Adnan A. Elfarra

Human Kidney Flavin-Containing Monooxygenases and Their Potential Roles in Cysteine S-Conjugate Metabolism and Nephrotoxicity
J Pharmacol Exp Ther 2003 304: 185-191. [Abstract] [Full Text] [PDF]  

Rommel G. Tirona, Brenda F. Leake, Allan W. Wolkoff, and Richard B. Kim

Human Organic Anion Transporting Polypeptide-C (SLC21A6) Is a Major Determinant of Rifampin-Mediated Pregnane X Receptor Activation
J Pharmacol Exp Ther 2003 304: 223-228. [Abstract] [Full Text] [PDF]  

Kesheng Zhao, Guoxiong Luo, Guo-Min Zhao, Peter W. Schiller, and Hazel H. Szeto

Transcellular Transport of a Highly Polar 3+ Net Charge Opioid Tetrapeptide
J Pharmacol Exp Ther 2003 304: 425-432. [Abstract] [Full Text] [PDF]  

Margit Spatzenegger, Hong Liu, Qinmi Wang, Andrea Debarber, Dennis R. Koop, and James R. Halpert

Analysis of Differential Substrate Selectivities of CYP2B6 and CYP2E1 by Site-Directed Mutagenesis and Molecular Modeling
J Pharmacol Exp Ther 2003 304: 477-487. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Katharine M. Walker, Laszlo Urban, Stephen J. Medhurst, Sadhana Patel, Mohanjit Panesar, Alyson J. Fox, and Peter McIntyre

The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain
J Pharmacol Exp Ther 2003 304: 56-62. [Abstract] [Full Text] [PDF]  

Lance R. McMahon and Charles P. France

Discriminative Stimulus Effects of Positive GABA_A Modulators and Other Anxiolytics, Sedatives, and Anticonvulsants in Untreated and Diazepam-Treated Monkeys
J Pharmacol Exp Ther 2003 304: 109-120. [Abstract] [Full Text] [PDF]  

Steven N. Sterious and Ellen A. Walker

Potency Differences for D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH₂ as an Antagonist of Peptide and Alkaloid µ-Agonists in an Antinociception Assay
J Pharmacol Exp Ther 2003 304: 301-309. [Abstract] [Full Text] [PDF]  

A. Kuzmin, J. Sandin, L. Terenius, and S. O. Ögren

Acquisition, Expression, and Reinstatement of Ethanol-Induced Conditioned Place Preference in Mice: Effects of Opioid Receptor-Like 1 Receptor Agonists and Naloxone
J Pharmacol Exp Ther 2003 304: 310-318. [Abstract] [Full Text] [PDF]  

John D. Alvaro, Jane R. Taylor, and Ronald S. Duman

Molecular and Behavioral Interactions Between Central Melanocortins and Cocaine
J Pharmacol Exp Ther 2003 304: 391-399. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

R. Macianskiene, S. Viappiani, K. R. Sipido, and K. Mubagwa

Slowing of the Inactivation of Cardiac Voltage-Dependent Sodium Channels by the Amiodarone Derivative 2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015)
J Pharmacol Exp Ther 2003 304: 130-138. [Abstract] [Full Text] [PDF]  

Allison W. Miller, Prasad V. G. Katakam, Hon-Chi Lee, Christina D. Tulbert, David W. Busija, and Neal L. Weintraub

Arachidonic Acid-Induced Vasodilation of Rat Small Mesenteric Arteries Is Lipoxygenase-Dependent
J Pharmacol Exp Ther 2003 304: 139-144. [Abstract] [Full Text] [PDF]  

María Luz Orliac, Roxana Peroni, Stella M Celuch, and Edda Adler-Graschinsky

Potentiation of Anandamide Effects in Mesenteric Beds Isolated from Endotoxemic Rats
J Pharmacol Exp Ther 2003 304: 179-184. [Abstract] [Full Text] [PDF]  

Michel Pelat, Patrick Verwaerde, Jean Galitzky, Max Lafontan, Michel Berlan, Jean-Michel Senard, and Jean-Louis Montastruc

High Isoproterenol Doses Are Required to Activate 3-Adrenoceptor-Mediated Functions in Dogs
J Pharmacol Exp Ther 2003 304: 246-253. [Abstract] [Full Text] [PDF]  

Banji Adegunloye, Eric Lamarre, and Robert S. Moreland

Quinine Inhibits Vascular Contraction Independent of Effects on Calcium or Myosin Phosphorylation
J Pharmacol Exp Ther 2003 304: 294-300. [Abstract] [Full Text] [PDF]  

Philip Hasbak, Ole Saetrum Opgaard, Karen Eskesen, Søren Schifter, Henrik Arendrup, Jenny Longmore, and Lars Edvinsson

Investigation of CGRP Receptors and Peptide Pharmacology in Human Coronary Arteries. Characterization with a Nonpeptide Antagonist
J Pharmacol Exp Ther 2003 304: 326-333. [Abstract] [Full Text] [PDF]  

Zhi Su, Kazuro Sugishita, Fenghua Li, Michael Ritter, and William H. Barry

Effects of FK506 on [Ca²⁺]_i Differ in Mouse and Rabbit Ventricular Myocytes
J Pharmacol Exp Ther 2003 304: 334-341. [Abstract] [Full Text] [PDF]  

Takao Makino, Yuichi Hattori, Naoyuki Matsuda, Hisao Onozuka, Ichiro Sakuma, and Akira Kitabatake

Effects of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade on -Adrenoceptor Signaling in Heart Failure Produced by Myocardial Infarction in Rabbits: Reversal of Altered Expression of -Adrenoceptor Kinase and G_i
J Pharmacol Exp Ther 2003 304: 370-379. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Patrizia Russo, Dario Arzani, Sonya Trombino, and Carla Falugi

c-myc Down-Regulation Induces Apoptosis in Human Cancer Cell Lines Exposed to RPR-115135 (C₃₁H₂₉NO₄), a Non-Peptidomimetic Farnesyltransferase Inhibitor
J Pharmacol Exp Ther 2003 304: 37-47. [Abstract] [Full Text] [PDF]  

Laurent Vernhet, Nathalie Allain, Marc Le Vée, Fabrice Morel, André Guillouzo, and Olivier Fardel

Blockage of Multidrug Resistance-Associated Proteins Potentiates the Inhibitory Effects of Arsenic Trioxide on CYP1A1 Induction by Polycyclic Aromatic Hydrocarbons
J Pharmacol Exp Ther 2003 304: 145-155. [Abstract] [Full Text] [PDF]  

Akira Kitamura, William Marszalec, Jay Z. Yeh, and Toshio Narahashi

Effects of Halothane and Propofol on Excitatory and Inhibitory Synaptic Transmission in Rat Cortical Neurons
J Pharmacol Exp Ther 2003 304: 162-171. [Abstract] [Full Text] [PDF]  

Kelly A. Berg, Kenda L. J. Evans, Jodie D. Cropper, and William P. Clarke

Temporal Regulation of Agonist Efficacy at 5-Hydroxytryptamine (5-HT)_1A and 5-HT_1B Receptors
J Pharmacol Exp Ther 2003 304: 200-205. [Abstract] [Full Text] [PDF]  

Deborah M. Kurrasch-Orbaugh, Val J. Watts, Eric L. Barker, and David E. Nichols

Serotonin 5-Hydroxytryptamine_2A Receptor-Coupled Phospholipase C and Phospholipase A₂ Signaling Pathways Have Different Receptor Reserves
J Pharmacol Exp Ther 2003 304: 229-237. [Abstract] [Full Text] [PDF]  

Curtis R. Kelly, Gary W. Williams, and Najam A. Sharif

Real-Time Intracellular Ca²⁺ Mobilization by Travoprost Acid, Bimatoprost, Unoprostone, and Other Analogs via Endogenous Mouse, Rat, and Cloned Human FP Prostaglandin Receptors
J Pharmacol Exp Ther 2003 304: 238-245. [Abstract] [Full Text] [PDF]  

Jesús Pintor, Assumpta Peral, Teresa Peláez, Silvia Martín, and Charles H. V. Hoyle

Presence of Diadenosine Polyphosphates in the Aqueous Humor: Their Effect on Intraocular Pressure
J Pharmacol Exp Ther 2003 304: 342-348. [Abstract] [Full Text] [PDF]  

Thierry Wurch, Elisa A. Boutet-Robinet, Christiane Palmier, Francis C. Colpaert, and Petrus J. Pauwels

Constitutive Coupling of a Chimeric Dopamine D₂/_1B Receptor to the Phospholipase C Pathway: Inverse Agonism to Silent Antagonism by Neuroleptic Drugs
J Pharmacol Exp Ther 2003 304: 380-390. [Abstract] [Full Text] [PDF]  

Clay W Scott, Cindy Sobotka-Briner, Deidre E. Wilkins, Robert T. Jacobs, James J. Folmer, William J. Frazee, Ratan V. Bhat, Smita V. Ghanekar, and David Aharony

Novel Small Molecule Inhibitors of Caspase-3 Block Cellular and Biochemical Features of Apoptosis
J Pharmacol Exp Ther 2003 304: 433-440. [Abstract] [Full Text] [PDF]  

Lee Campbell, Abedel-Nasser G. Abulrob, Lana E. Kandalaft, Steven Plummer, Andrew J. Hollins, Alan Gibbs, and Mark Gumbleton

Constitutive Expression of P-Glycoprotein in Normal Lung Alveolar Epithelium and Functionality in Primary Alveolar Epithelial Cultures
J Pharmacol Exp Ther 2003 304: 441-452. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Atsushi Masamune, Masahiro Satoh, Kazuhiro Kikuta, Yoshitaka Sakai, Akihiko Satoh, and Tooru Shimosegawa

Inhibition of p38 Mitogen-Activated Protein Kinase Blocks Activation of Rat Pancreatic Stellate Cells
J Pharmacol Exp Ther 2003 304: 8-14. [Abstract] [Full Text] [PDF]  

D. N. K. Sarma, Kuldip Banwait, Ashim Basak, Anthony J. DiMarino, and Satish Rattan

Inhibitory Effect of ₃-Adrenoceptor Agonist in Lower Esophageal Sphincter Smooth Muscle: In Vitro Studies
J Pharmacol Exp Ther 2003 304: 48-55. [Abstract] [Full Text] [PDF]  

Mohamed H. Ahmed, Nick Ashton, and Richard J. Balment

The Effect of Chloroquine on Renal Function and Vasopressin Secretion: A Nitric Oxide-Dependent Effect
J Pharmacol Exp Ther 2003 304: 156-161. [Abstract] [Full Text] [PDF]  

Lori A. Birder, Susanna Kiss, William C. de Groat, Alessandro Lecci, and Carlo A. Maggi

Effect of Nepadutant, a Neurokinin 2 Tachykinin Receptor Antagonist, on Immediate-Early Gene Expression after Trinitrobenzenesulfonic Acid-Induced Colitis in the Rat
J Pharmacol Exp Ther 2003 304: 272-276. [Abstract] [Full Text] [PDF]  

Junji Yamashita, Satomi Kita, Takahiro Iwamoto, Masaya Ogata, Masanori Takaoka, Naoko Tazawa, Mitsunori Nishikawa, Koji Wakimoto, Munekazu Shigekawa, Issei Komuro, and Yasuo Matsumura

Attenuation of Ischemia/Reperfusion-Induced Renal Injury in Mice Deficient in Na⁺/Ca²⁺ Exchanger
J Pharmacol Exp Ther 2003 304: 284-293. [Abstract] [Full Text] [PDF]  

Christian V. Hulzebos, Henk Wolters, Torsten Plösch, Werner Kramer, Siegfried Stengelin, Frans Stellaard, Pieter J. J. Sauer, Henkjan J. Verkade, and Folkert Kuipers

Cyclosporin A and Enterohepatic Circulation of Bile Salts in Rats: Decreased Cholate Synthesis but Increased Intestinal Reabsorption
J Pharmacol Exp Ther 2003 304: 356-363. [Abstract] [Full Text] [PDF]  

Penny L. Sappington, Xiaonan Han, Runkuan Yang, Russell L. Delude, and Mitchell P. Fink

Ethyl Pyruvate Ameliorates Intestinal Epithelial Barrier Dysfunction in Endotoxemic Mice and Immunostimulated Caco-2 Enterocytic Monolayers
J Pharmacol Exp Ther 2003 304: 464-476. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Paul R. Eynott, Niko Paavolainen, David A. Groneberg, Alistair Noble, Michael Salmon, Puneeta Nath, Sum-Yee Leung, and K. Fan Chung

Role of Nitric Oxide in Chronic Allergen-Induced Airway Cell Proliferation and Inflammation
J Pharmacol Exp Ther 2003 304: 22-29. [Abstract] [Full Text] [PDF]  

Mariana L. Vale, Jaciara B. Marques, Camila A. Moreira, Francisco Aírton C. Rocha, Sérgio H. Ferreira, Stephen Poole, Fernando Q. Cunha, and Ronaldo A. Ribeiro

Antinociceptive Effects of Interleukin-4, -10, and -13 on the Writhing Response in Mice and Zymosan-Induced Knee Joint Incapacitation in Rats
J Pharmacol Exp Ther 2003 304: 102-108. [Abstract] [Full Text] [PDF]  

Michael D. Southall, Tao Li, Lera S. Gharibova, Yong Pei, Grant D. Nicol, and Jeffrey B. Travers

Activation of Epidermal Vanilloid Receptor-1 Induces Release of Proinflammatory Mediators in Human Keratinocytes
J Pharmacol Exp Ther 2003 304: 217-222. [Abstract] [Full Text] [PDF]  

Kathleen M. K. Boje, David Jaworowicz, Jr., and Joseph J. Raybon

Neuroinflammatory Role of Prostaglandins during Experimental Meningitis: Evidence Suggestive of an in Vivo Relationship between Nitric Oxide and Prostaglandins
J Pharmacol Exp Ther 2003 304: 319-325. [Abstract] [Full Text] [PDF]  

Guillaume Monneret, Chantal Cossette, Sylvie Gravel, Joshua Rokach, and William S. Powell

15R-Methyl-Prostaglandin D₂ Is a Potent and Selective CRTH2/DP₂ Receptor Agonist in Human Eosinophils
J Pharmacol Exp Ther 2003 304: 349-355. [Abstract] [Full Text] [PDF]  

Kathleen J. Myers, Sreekant Murthy, Anne Flanigan, Donna R. Witchell, Madeline Butler, Susan Murray, Andrew Siwkowski, Deborah Goodfellow, Karen Madsen, and Brenda Baker

Antisense Oligonucleotide Blockade of Tumor Necrosis Factor- in Two Murine Models of Colitis
J Pharmacol Exp Ther 2003 304: 411-424. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Heather L. Kimmel, F. Ivy Carroll, and Michael J. Kuhar

Withdrawal from Repeated Cocaine Alters Dopamine Transporter Protein Turnover in the Rat Striatum
J Pharmacol Exp Ther 2003 304: 15-21. [Abstract] [Full Text] [PDF]  

Yuri A. Blednov, S. Jung, H. Alva, D. Wallace, T. Rosahl, P.-J. Whiting, and R. Adron Harris

Deletion of the 1 or 2 Subunit of GABA_A Receptors Reduces Actions of Alcohol and Other Drugs
J Pharmacol Exp Ther 2003 304: 30-36. [Abstract] [Full Text] [PDF]  

Sylvie Chalon, Jari Tarkiainen, Lucette Garreau, Hakan Hall, Patrick Emond, Johnny Vercouillie, Lars Farde, Philippe Dasse, Katarina Varnas, Jean-Claude Besnard, Christer Halldin, and Denis Guilloteau

Pharmacological Characterization of N,N-Dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a Ligand of the Serotonin Transporter with High Affinity and Selectivity
J Pharmacol Exp Ther 2003 304: 81-87. [Abstract] [Full Text] [PDF]  

S.A.G. Visser, F.L.C. Wolters, J. M. Gubbens-Stibbe, E. Tukker, P. H. van der Graaf, L. A. Peletier, and M. Danhof

Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of the Electroencephalogram Effects of GABA_A Receptor Modulators: In Vitro-in Vivo Correlations
J Pharmacol Exp Ther 2003 304: 88-101. [Abstract] [Full Text] [PDF]  

Xinkang Wang, Hugh Wang, Lin Xu, Dennis J. Rozanski, Taku Sugawara, Pak H. Chan, James M. Trzaskos, and Giora Z. Feuerstein

Significant Neuroprotection against Ischemic Brain Injury by Inhibition of the MEK1 Protein Kinase in Mice: Exploration of Potential Mechanism Associated with Apoptosis
J Pharmacol Exp Ther 2003 304: 172-178. [Abstract] [Full Text] [PDF]  

Hugh E. Criswell, Zhen Ming, Benjamin L. Griffith, and George R. Breese

Comparison of Effect of Ethanol on N-Methyl-D-aspartate- and GABA-Gated Currents from Acutely Dissociated Neurons: Absence of Regional Differences in Sensitivity to Ethanol
J Pharmacol Exp Ther 2003 304: 192-199. [Abstract] [Full Text] [PDF]  

Cynthia L. Gentry, Lincoln H. Wilkins, Jr., and Ronald J. Lukas

Effects of Prolonged Nicotinic Ligand Exposure on Function of Heterologously Expressed, Human 42- and 44-Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 2003 304: 206-216. [Abstract] [Full Text] [PDF]  

Máriton D. Santos, Edna F. R. Pereira, Yasco Aracava, Newton G. Castro, William P. Fawcett, William R. Randall, and Edson X. Albuquerque

Low Concentrations of Pyridostigmine Prevent Soman-Induced Inhibition of GABAergic Transmission in the Central Nervous System: Involvement of Muscarinic Receptors
J Pharmacol Exp Ther 2003 304: 254-265. [Abstract] [Full Text] [PDF]  

Cheng Wang, Justin McInnis, J. Brett West, Jinfeng Bao, Noelle Anastasio, Jon A. Guidry, Yanping Ye, Daniela Salvemini, and Kenneth M. Johnson

Blockade of Phencyclidine-Induced Cortical Apoptosis and Deficits in Prepulse Inhibition by M40403, a Superoxide Dismutase Mimetic
J Pharmacol Exp Ther 2003 304: 266-271. [Abstract] [Full Text] [PDF]  

Samer J. Nuwayhid and Linda L. Werling

₁ Receptor Agonist-Mediated Regulation of N-Methyl-D-aspartate-Stimulated [³H]Dopamine Release Is Dependent upon Protein Kinase C
J Pharmacol Exp Ther 2003 304: 364-369. [Abstract] [Full Text] [PDF]  

Lincoln H. Wilkins, Jr., Vladimir P. Grinevich, Joshua T. Ayers, Peter A. Crooks, and Linda P. Dwoskin

N-n-Alkylnicotinium Analogs, a Novel Class of Nicotinic Receptor Antagonists: Interaction with 42* and 7* Neuronal Nicotinic Receptors
J Pharmacol Exp Ther 2003 304: 400-410. [Abstract] [Full Text] [PDF]  

Annamaria De Luca, Sabata Pierno, Antonella Liantonio, Michela Cetrone, Claudia Camerino, Bodvael Fraysse, Massimo Mirabella, Serenella Servidei, Urs T. Rüegg, and Diana Conte Camerino

Enhanced Dystrophic Progression in mdx Mice by Exercise and Beneficial Effects of Taurine and Insulin-Like Growth Factor-1
J Pharmacol Exp Ther 2003 304: 453-463. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Xiuli Liu and Rick G. Schnellmann

Calpain Mediates Progressive Plasma Membrane Permeability and Proteolysis of Cytoskeleton-Associated Paxillin, Talin, and Vinculin during Renal Cell Death
J Pharmacol Exp Ther 2003 304: 63-70. [Abstract] [Full Text] [PDF]  

Erik J. Martin, William J. Racz, and Poh-Gek Forkert

Mitochondrial Dysfunction Is an Early Manifestation of 1,1-Dichloroethylene-Induced Hepatotoxicity in Mice
J Pharmacol Exp Ther 2003 304: 121-129. [Abstract] [Full Text] [PDF]  

Jeffrey W. Card, William J. Racz, James F. Brien, and Thomas E. Massey

Attenuation of Amiodarone-Induced Pulmonary Fibrosis by Vitamin E Is Associated with Suppression of Transforming Growth Factor-₁ Gene Expression but Not Prevention of Mitochondrial Dysfunction
J Pharmacol Exp Ther 2003 304: 277-283. [Abstract] [Full Text] [PDF]  

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