PERSPECTIVES IN PHARMACOLOGY:

David P. Westfall, Latchezar D. Todorov, and Svetlana T. Mihaylova-Todorova

ATP as a Cotransmitter in Sympathetic Nerves and Its Inactivation by Releasable Enzymes
J Pharmacol Exp Ther 2002 303: 439-444. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Suparat Khamdang, Michio Takeda, Rie Noshiro, Shinichi Narikawa, Atsushi Enomoto, Naohiko Anzai, Pawinee Piyachaturawat, and Hitoshi Endou

Interactions of Human Organic Anion Transporters and Human Organic Cation Transporters with Nonsteroidal Anti-Inflammatory Drugs
J Pharmacol Exp Ther 2002 303: 534-539. [Abstract] [Full Text] [PDF]  

Blaire L. Osborn, Henrik S. Olsen, Bernardetta Nardelli, James H. Murray, Joe X. H. Zhou, Andrew Garcia, Gordon Moody, Liubov S. Zaritskaya, and Cynthia Sung

Pharmacokinetic and Pharmacodynamic Studies of a Human Serum Albumin-Interferon- Fusion Protein in Cynomolgus Monkeys
J Pharmacol Exp Ther 2002 303: 540-548. [Abstract] [Full Text] [PDF]  

Kiho Lee, Chee Ng, Kim L. R. Brouwer, and Dhiren R. Thakker

Secretory Transport of Ranitidine and Famotidine across Caco-2 Cell Monolayers
J Pharmacol Exp Ther 2002 303: 574-580. [Abstract] [Full Text] [PDF]  

Helen M. Dodds, Peter J. Tobin, Clinton F. Stewart, Pam Cheshire, Suzan Hanna, Peter Houghton, and Laurent P. Rivory

The Importance of Tumor Glucuronidase in the Activation of Irinotecan in a Mouse Xenograft Model
J Pharmacol Exp Ther 2002 303: 649-655. [Abstract] [Full Text] [PDF]  

Ralph Theo Schermuly, Andreas Schulz, Hossein Ardeschir Ghofrani, Arne Meidow, Frank Rose, Axel Roehl, Norbert Weissmann, Michael Hildebrand, Julia Kurz, Friedrich Grimminger, Dieter Walmrath, and Werner Seeger

Pharmacokinetics and Metabolism of Infused versus Inhaled Iloprost in Isolated Rabbit Lungs
J Pharmacol Exp Ther 2002 303: 741-745. [Abstract] [Full Text] [PDF]  

Ken A. Witt, Jason D. Huber, Richard D. Egleton, and Thomas P. Davis

Pluronic P85 Block Copolymer Enhances Opioid Peptide Analgesia
J Pharmacol Exp Ther 2002 303: 760-767. [Abstract] [Full Text] [PDF]  

Jerry Z. Yang, Weiqing Chen, and Ronald T. Borchardt

In Vitro Stability and In Vivo Pharmacokinetic Studies of a Model Opioid Peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and Its Cyclic Prodrugs
J Pharmacol Exp Ther 2002 303: 840-848. [Abstract] [Full Text] [PDF]  

Weiqing Chen, Jerry Z. Yang, Rikke Andersen, Lisbeth H. Nielsen, and Ronald T. Borchardt

Evaluation of the Permeation Characteristics of a Model Opioid Peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and Its Cyclic Prodrugs across the Blood-Brain Barrier Using an In Situ Perfused Rat Brain Model
J Pharmacol Exp Ther 2002 303: 849-857. [Abstract] [Full Text] [PDF]  

Yasuhiro Tsutsumi, Tsuneo Deguchi, Mikihisa Takano, Akira Takadate, W. Edward Lindup, and Masaki Otagiri

Renal Disposition of a Furan Dicarboxylic Acid and Other Uremic Toxins in the Rat
J Pharmacol Exp Ther 2002 303: 880-887. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Elizabeth A. Bolan, Ronald J. Tallarida, and Gavril W. Pasternak

Synergy between µ Opioid Ligands: Evidence for Functional Interactions among µ Opioid Receptor Subtypes
J Pharmacol Exp Ther 2002 303: 557-562. [Abstract] [Full Text] [PDF]  

Joshua A. Lile, Drake Morgan, Anne M. Birmingham, Zhixia Wang, William L. Woolverton, Huw M. L. Davies, and Michael A. Nader

The Reinforcing Efficacy of the Dopamine Reuptake Inhibitor 2-Propanoyl-3-(4-tolyl)-tropane (PTT) as Measured by a Progressive-Ratio Schedule and a Choice Procedure in Rhesus Monkeys
J Pharmacol Exp Ther 2002 303: 640-648. [Abstract] [Full Text] [PDF]  

Sandra D. Comer and Eric D. Collins

Self-Administration of Intravenous Buprenorphine and the Buprenorphine/Naloxone Combination by Recently Detoxified Heroin Abusers
J Pharmacol Exp Ther 2002 303: 695-703. [Abstract] [Full Text] [PDF]  

Barry Dubinsky, Anil H. Vaidya, Daniel I. Rosenthal, Coralie Hochman, Jeffrey J. Crooke, Samantha DeLuca, Ann DeVine, Cathy T. Cheo-Isaacs, Alexandre R. Carter, Alfonzo D. Jordan, Allen B. Reitz, and Richard P. Shank

5-Ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N- (2-fluorophenyl)carboxamide (RWJ-51204), a New Nonbenzodiazepine Anxiolytic
J Pharmacol Exp Ther 2002 303: 777-790. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Zhuo-Wei Hu, Reinhold Kerb, Xiao-You Shi, Tzuping Wei-Lavery, and Brian B. Hoffman

Angiotensin II Increases Expression of Cyclooxygenase-2: Implications for the Function of Vascular Smooth Muscle Cells
J Pharmacol Exp Ther 2002 303: 563-573. [Abstract] [Full Text] [PDF]  

David Bell, Adrian R. Allen, Elizabeth J. Kelso, Ambikaipakan Balasubramaniam, and Barbara J. McDermott

Induction of Hypertrophic Responsiveness of Cardiomyocytes to Neuropeptide Y in Response to Pressure Overload
J Pharmacol Exp Ther 2002 303: 581-591. [Abstract] [Full Text] [PDF]  

R. Micheletti, G. G. Mattera, M. Rocchetti, A. Schiavone, M. F. Loi, A. Zaza, R. J. P. Gagnol, S. De Munari, P. Melloni, P. Carminati, G. Bianchi, and P. Ferrari

Pharmacological Profile of the Novel Inotropic Agent (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride (PST2744)
J Pharmacol Exp Ther 2002 303: 592-600. [Abstract] [Full Text] [PDF]  

Weiqun Shen, Robert M. Gill, Bonita D. Jones, Jian-Ping Zhang, Angela K. Corbly, and Mitchell I. Steinberg

Combined Inotropic and Bradycardic Effects of a Sodium Channel Enhancer in Conscious Dogs with Heart Failure: A Mechanism for Improved Myocardial Efficiency Compared with Dobutamine
J Pharmacol Exp Ther 2002 303: 673-680. [Abstract] [Full Text] [PDF]  

Jun-ichi Oka, Michiaki Imamura, Eiichiro Hatta, Ryushi Maruyama, Mitsuhiro Isaka, Toshifumi Murashita, and Keishu Yasuda

Carrier-Mediated Norepinephrine Release and Reperfusion Arrhythmias Induced by Protracted Ischemia in Isolated Perfused Guinea Pig Hearts: Effect of Presynaptic Modulation by ₂-Adrenoceptor in Mild Hypothermic Ischemia
J Pharmacol Exp Ther 2002 303: 681-687. [Abstract] [Full Text] [PDF]  

Alexander N. Katchman, Kelly A. McGroary, Michael J. Kilborn, Craig A. Kornick, Paolo L. Manfredi, Raymond L. Woosley, and Steven N. Ebert

Influence of Opioid Agonists on Cardiac Human Ether-a-go-go-related Gene K⁺ Currents
J Pharmacol Exp Ther 2002 303: 688-694. [Abstract] [Full Text] [PDF]  

Dan Ye, David Zhang, Christine Oltman, Kevin Dellsperger, Hon-Chi Lee, and Mike VanRollins

Cytochrome P-450 Epoxygenase Metabolites of Docosahexaenoate Potently Dilate Coronary Arterioles by Activating Large-Conductance Calcium-Activated Potassium Channels
J Pharmacol Exp Ther 2002 303: 768-776. [Abstract] [Full Text] [PDF]  

Petr Vetrovsky, Jean-Luc Boucher, Christa Schott, Petra Beranova, Karel Chalupsky, Noëlle Callizot, Bernard Muller, Gustav Entlicher, Daniel Mansuy, and Jean-Claude Stoclet

Involvement of NO in the Endothelium-Independent Relaxing Effects of N-Hydroxy-L-arginine and Other Compounds Bearing a C=NOH Function in the Rat Aorta
J Pharmacol Exp Ther 2002 303: 823-830. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

J. Alcorn, X. Lu, J. A. Moscow, and P. J. McNamara

Transporter Gene Expression in Lactating and Nonlactating Human Mammary Epithelial Cells Using Real-Time Reverse Transcription-Polymerase Chain Reaction
J Pharmacol Exp Ther 2002 303: 487-496. [Abstract] [Full Text] [PDF]  

S. Carnesecchi, A. Bradaia, B. Fischer, D. Coelho, M. Schöller-Guinard, F. Gosse, and F. Raul

Perturbation by Geraniol of Cell Membrane Permeability and Signal Transduction Pathways in Human Colon Cancer Cells
J Pharmacol Exp Ther 2002 303: 711-715. [Abstract] [Full Text] [PDF]  

John C. Quinn, Nadine N. Johnson-Farley, JiYoung Yoon, and Daniel S. Cowen

Activation of Extracellular-Regulated Kinase by 5-Hydroxytryptamine_2A Receptors in PC12 Cells is Protein Kinase C-Independent and Requires Calmodulin and Tyrosine Kinases
J Pharmacol Exp Ther 2002 303: 746-752. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Chung-Hui Kim, Su-Jung Park, and Suk-Hee Lee

A Targeted Inhibition of DNA-Dependent Protein Kinase Sensitizes Breast Cancer Cells Following Ionizing Radiation
J Pharmacol Exp Ther 2002 303: 753-759. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Maria Gazouli, Zeqiu Han, and Vassilios Papadopoulos

Identification of a Peptide Antagonist to the Peripheral-Type Benzodiazepine Receptor That Inhibits Hormone-Stimulated Leydig Cell Steroid Formation
J Pharmacol Exp Ther 2002 303: 627-632. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Hisato Igarashi, Tetsuhide Ito, Tapas K. Pradhan, Samuel A. Mantey, Wei Hou, David H. Coy, and Robert T. Jensen

Elucidation of the Vasoactive Intestinal Peptide Pharmacophore for VPAC₂ Receptors in Human and Rat and Comparison to the Pharmacophore for VPAC₁ Receptors
J Pharmacol Exp Ther 2002 303: 445-460. [Abstract] [Full Text] [PDF]  

Hajime Higuchi, Steven F. Bronk, Makiko Taniai, Ali Canbay, and Gregory J. Gores

Cholestasis Increases Tumor Necrosis Factor-Related Apoptotis-Inducing Ligand (TRAIL)-R2/DR5 Expression and Sensitizes the Liver to TRAIL-Mediated Cytotoxicity
J Pharmacol Exp Ther 2002 303: 461-467. [Abstract] [Full Text] [PDF]  

Shinichi Kato, Yoshihiro Ogawa, Kenji Kanatsu, Mitsuaki Okayama, Toshio Watanabe, Tetsuo Arakawa, and Koji Takeuchi

Ulcerogenic Influence of Selective Cyclooxygenase-2 Inhibitors in the Rat Stomach with Adjuvant-Induced Arthritis
J Pharmacol Exp Ther 2002 303: 503-509. [Abstract] [Full Text] [PDF]  

Joost Rothbarth, Rolf W. Sparidans, Jos H. Beijnen, Leo J. Schultze Kool, Hein Putter, Cornelis J. H. van de Velde, and Gerard J. Mulder

Reduced Liver Uptake of Arterially Infused Melphalan during Retrograde Rat Liver Perfusion with Unaffected Liver Tumor Uptake
J Pharmacol Exp Ther 2002 303: 736-740. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Taiyo Suganuma, Kaoru Irie, Emiko Fujii, Toshimasa Yoshioka, and Takamura Muraki

Effect of Heat Stress on Lipopolysaccharide-Induced Vascular Permeability Change in Mice
J Pharmacol Exp Ther 2002 303: 656-663. [Abstract] [Full Text] [PDF]  

Christopher S. Stevenson, Elizabeth A. Capper, Amy K. Roshak, Brian Marquez, Chris Eichman, Jeffrey R. Jackson, Michael Mattern, William H. Gerwick, Robert S. Jacobs, and Lisa A. Marshall

The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore
J Pharmacol Exp Ther 2002 303: 858-866. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Takanori Esaki, Yoshiaki Itoh, Kazuaki Shimoji, Michelle Cook, Jane Jehle, and Louis Sokoloff

Effects of Dopamine Receptor Blockade on Cerebral Blood Flow Response to Somatosensory Stimulation in the Unanesthetized Rat
J Pharmacol Exp Ther 2002 303: 497-502. [Abstract] [Full Text] [PDF]  

Melanie B. Kulick and Ivar von Kügelgen

P2Y-Receptors Mediating an Inhibition of the Evoked Entry of Calcium through N-Type Calcium Channels at Neuronal Processes
J Pharmacol Exp Ther 2002 303: 520-526. [Abstract] [Full Text] [PDF]  

Rui Tao and Sidney B. Auerbach

Opioid Receptor Subtypes Differentially Modulate Serotonin Efflux in the Rat Central Nervous System
J Pharmacol Exp Ther 2002 303: 549-556. [Abstract] [Full Text] [PDF]  

Zheng-Xiong Xi, Sammanda Ramamoorthy, David A. Baker, Hui Shen, Devadoss J. Samuvel, and Peter W. Kalivas

Modulation of Group II Metabotropic Glutamate Receptor Signaling by Chronic Cocaine
J Pharmacol Exp Ther 2002 303: 608-615. [Abstract] [Full Text] [PDF]  

S. A. G. Visser, W. W. F. T. Gladdines, P. H. van der Graaf, L. A. Peletier, and M. Danhof

Neuroactive Steroids Differ in Potency but Not in Intrinsic Efficacy at the GABA_A Receptor in Vivo
J Pharmacol Exp Ther 2002 303: 616-626. [Abstract] [Full Text] [PDF]  

Jennifer M. Kulak, John L. Musachio, J. Michael McIntosh, and Maryka Quik

Declines in Different 2* Nicotinic Receptor Populations in Monkey Striatum after Nigrostriatal Damage
J Pharmacol Exp Ther 2002 303: 633-639. [Abstract] [Full Text] [PDF]  

Anthony S. Rauhut, Stephanie N. Mullins, Linda P. Dwoskin, and Michael T. Bardo

Reboxetine: Attenuation of Intravenous Nicotine Self-Administration in Rats
J Pharmacol Exp Ther 2002 303: 664-672. [Abstract] [Full Text] [PDF]  

Rui Tao and Sidney B. Auerbach

GABAergic and Glutamatergic Afferents in the Dorsal Raphe Nucleus Mediate Morphine-Induced Increases in Serotonin Efflux in the Rat Central Nervous System
J Pharmacol Exp Ther 2002 303: 704-710. [Abstract] [Full Text] [PDF]  

Bradley J. Undem and Marian Kollarik

Characterization of the Vanilloid Receptor 1 Antagonist Iodo-Resiniferatoxin on the Afferent and Efferent Function of Vagal Sensory C-Fibers
J Pharmacol Exp Ther 2002 303: 716-722. [Abstract] [Full Text] [PDF]  

Daniel C. Broom, Joshua F. Nitsche, John E. Pintar, Kenner C. Rice, James H. Woods, and John R. Traynor

Comparison of Receptor Mechanisms and Efficacy Requirements for -Agonist-Induced Convulsive Activity and Antinociception in Mice
J Pharmacol Exp Ther 2002 303: 723-729. [Abstract] [Full Text] [PDF]  

Mark J. Field, M. Isabel Gonzalez, Ronald J. Tallarida, and Lakhbir Singh

Gabapentin and the Neurokinin₁ Receptor Antagonist CI-1021 Act Synergistically in Two Rat Models of Neuropathic Pain
J Pharmacol Exp Ther 2002 303: 730-735. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Lisa Maiofiss, Didier Cussac, Valérie Audinot, Jean-A. Boutin, and Adrian Newman-Tancredi

Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. I. A Multivariate Analysis of the Binding Profiles of 14 Drugs at 21 Native and Cloned Human Receptor Subtypes
J Pharmacol Exp Ther 2002 303: 791-804. [Abstract] [Full Text] [PDF]  

Adrian Newman-Tancredi, Didier Cussac, Valérie Audinot, Jean-Paul Nicolas, Frédéric De Ceuninck, Jean-A. Boutin, and Mark J. Millan

Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. II. Agonist and Antagonist Properties at Subtypes of Dopamine D₂-Like Receptor and ₁/₂-Adrenoceptor
J Pharmacol Exp Ther 2002 303: 805-814. [Abstract] [Full Text] [PDF]  

Adrian Newman-Tancredi, Didier Cussac, Yann Quentric, Manuelle Touzard, Laurence Verrièle, Nathalie Carpentier, and Mark J. Millan

Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. III. Agonist and Antagonist Properties at Serotonin, 5-HT₁ and 5-HT₂, Receptor Subtypes
J Pharmacol Exp Ther 2002 303: 815-822. [Abstract] [Full Text] [PDF]  

Jie Yuan, Branden J. Cord, Una D. McCann, Brian T. Callahan, and George A. Ricaurte

Effect of Glucoprivation on Serotonin Neurotoxicity Induced by Substituted Amphetamines
J Pharmacol Exp Ther 2002 303: 831-839. [Abstract] [Full Text] [PDF]  

Hsiang-en Wu, Hirokazu Mizoguchi, Maia Terashvili, Randy J. Leitermann, Kuei-chun Hung, James M. Fujimoto, and Leon F. Tseng

Spinal Pretreatment with Antisense Oligodeoxynucleotides against Exon-1, -4, or -8 of µ-Opioid Receptor Clone Leads to Differential Loss of Spinal Endomorphin-1-and Endomorphin-2-Induced Antinociception in the Mouse
J Pharmacol Exp Ther 2002 303: 867-873. [Abstract] [Full Text] [PDF]  

Kuei-chun Hung, Hsiang-en Wu, Hirokazu Mizoguchi, Shinobu Sakurada, Toru Okayama, Tsutomu Fujimura, Kimie Murayama, Tsukasa Sakurada, James M. Fujimoto, and Leon F. Tseng

D-Pro²-Endomorphin-1 and D-Pro²-Endomorphin-2, Respectively, Attenuate the Antinociception Induced by Endomorphin-1 and Endomorphin-2 Given Intrathecally in the Mouse
J Pharmacol Exp Ther 2002 303: 874-879. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Tamara R. Knight, Ye-Shih Ho, Anwar Farhood, and Hartmut Jaeschke

Peroxynitrite Is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by Glutathione
J Pharmacol Exp Ther 2002 303: 468-475. [Abstract] [Full Text] [PDF]  

Lawrence H. Lash, David A. Putt, and Larry H. Matherly

Protection of NRK-52E Cells, a Rat Renal Proximal Tubular Cell Line, from Chemical-Induced Apoptosis by Overexpression of a Mitochondrial Glutathione Transporter
J Pharmacol Exp Ther 2002 303: 476-486. [Abstract] [Full Text] [PDF]  

K. Prabhakaran, L. Li, J. L. Borowitz, and G. E. Isom

Cyanide Induces Different Modes of Death in Cortical and Mesencephalon Cells
J Pharmacol Exp Ther 2002 303: 510-519. [Abstract] [Full Text] [PDF]  

Erica L. Unger, Pascale Mazzola-Pomietto, Dennis L. Murphy, and Anne M. Andrews

2'-NH₂-MPTP [1-Methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] Depletes Serotonin and Norepinephrine in Rats: A Comparison with 2'-CH₃-MPTP [1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine]
J Pharmacol Exp Ther 2002 303: 527-533. [Abstract] [Full Text] [PDF]  

Fábio E. Mingatto, Tiago Rodrigues, Acácio A. Pigoso, Sérgio A. Uyemura, Carlos Curti, and Antonio C. Santos

The Critical Role of Mitochondrial Energetic Impairment in the Toxicity of Nimesulide to Hepatocytes
J Pharmacol Exp Ther 2002 303: 601-607. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Paraherquamide and 2-Deoxy-paraherquamide Distinguish Cholinergic Receptor Subtypes in Ascaris Muscle"
J Pharmacol Exp Ther 2002 303: 888. [Full Text] [PDF]  

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