PERSPECTIVES IN PHARMACOLOGY:

Robert Schwarcz and Roberto Pellicciari

Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
J Pharmacol Exp Ther 2002 303: 1-10. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

William T. Phillips, Luis A. Medina, Robert Klipper, and Beth Goins

A Novel Approach for the Increased Delivery of Pharmaceutical Agents to Peritoneum and Associated Lymph Nodes
J Pharmacol Exp Ther 2002 303: 11-16. [Abstract] [Full Text] [PDF]  

Vincent J. Wacher, Jeffrey A. Silverman, Susan Wong, Paulina Tran-Tau, Amy O. Chan, Anne Chai, Xiang-Qing Yu, Daniel O'Mahony, and Zeibun Ramtoola

Sirolimus Oral Absorption in Rats Is Increased by Ketoconazole but Is Not Affected by D--Tocopheryl Poly(Ethylene Glycol 1000) Succinate
J Pharmacol Exp Ther 2002 303: 308-313. [Abstract] [Full Text] [PDF]  

Kazuto Yasuda, Lu-bin Lan, Dominique Sanglard, Katryn Furuya, John D. Schuetz, and Erin G. Schuetz

Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein
J Pharmacol Exp Ther 2002 303: 323-332. [Abstract] [Full Text] [PDF]  

Judy Raucy, Lyndon Warfe, Mei-Fei Yueh, and Scott W. Allen

A Cell-Based Reporter Gene Assay for Determining Induction of CYP3A4 in a High-Volume System
J Pharmacol Exp Ther 2002 303: 412-423. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Maiko Okada, Takayuki Nakagawa, Masabumi Minami, and Masamichi Satoh

Analgesic Effects of Intrathecal Administration of P2Y Nucleotide Receptor Agonists UTP and UDP in Normal and Neuropathic Pain Model Rats
J Pharmacol Exp Ther 2002 303: 66-73. [Abstract] [Full Text] [PDF]  

W. L. Woolverton, R. Ranaldi, Z. Wang, G. A. Ordway, I. A. Paul, P. Petukhov, and A. Kozikowski

Reinforcing Strength of a Novel Dopamine Transporter Ligand: Pharmacodynamic and Pharmacokinetic Mechanisms
J Pharmacol Exp Ther 2002 303: 211-217. [Abstract] [Full Text] [PDF]  

Tadatoshi Muratani, Toshiaki Minami, Utako Enomoto, Masato Sakai, Emiko Okuda-Ashitaka, Kimihiro Kiyokane, Hidemaro Mori, and Seiji Ito

Characterization of Nociceptin/Orphanin FQ-Induced Pain Responses by the Novel Receptor Antagonist N-(4-Amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) Benzamide Monohydrochloride
J Pharmacol Exp Ther 2002 303: 424-430. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Raymond R. Mattingly, Richard A. Gibbs, Raymond E. Menard, and John J. Reiners, Jr.

Potent Suppression of Proliferation of A10 Vascular Smooth Muscle Cells by Combined Treatment with Lovastatin and 3-Allylfarnesol, an Inhibitor of Protein Farnesyltransferase
J Pharmacol Exp Ther 2002 303: 74-81. [Abstract] [Full Text] [PDF]  

Gary J. Grover, Albert J. D'Alonzo, Raymond B. Darbenzio, Charles S. Parham, Thomas A. Hess, and Mohinder S. Bathala

In Vivo Characterization of the Mitochondrial Selective K_ATP Opener (3R)-trans-4-((4-Chlorophenyl)-N-(1H-imidazol-2-ylmethyl)dimethyl-2H-1-benzopyran-6-carbonitril Monohydrochloride (BMS-191095): Cardioprotective, Hemodynamic, and Electrophysiological Effects
J Pharmacol Exp Ther 2002 303: 132-140. [Abstract] [Full Text] [PDF]  

Catherine Vergely, Caroline Perrin-Sarrado, Gaëlle Clermont, and Luc Rochette

Postischemic Recovery and Oxidative Stress Are Independent of Nitric-Oxide Synthases Modulation in Isolated Rat Heart
J Pharmacol Exp Ther 2002 303: 149-157. [Abstract] [Full Text] [PDF]  

Olaf Stanger, Hans-Juergen Semmelrock, Willibald Wonisch, Ursula Bös, Edmund Pabst, and Thomas C. Wascher

Effects of Folate Treatment and Homocysteine Lowering on Resistance Vessel Reactivity in Atherosclerotic Subjects
J Pharmacol Exp Ther 2002 303: 158-162. [Abstract] [Full Text] [PDF]  

Amber Russell, Amy Banes, Hilary Berlin, Gregory D. Fink, and Stephanie W. Watts

5-Hydroxytryptamine_2B Receptor Function Is Enhanced in the N-Nitro-L-arginine Hypertensive Rat
J Pharmacol Exp Ther 2002 303: 179-187. [Abstract] [Full Text] [PDF]  

Jian Zhang and Abdel A. Abdel-Rahman

The Hypotensive Action of Rilmenidine is Dependent on Functional N-Methyl-D-aspartate Receptor in the Rostral Ventrolateral Medulla of Conscious Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2002 303: 204-210. [Abstract] [Full Text] [PDF]  

John J. Borg, Kathryn H. Yuill, Jules C. Hancox, Ian C. Spencer, and Roland Z. Kozlowski

Inhibitory Effects of the Antiestrogen Agent Clomiphene on Cardiac Sarcolemmal Anionic and Cationic Currents
J Pharmacol Exp Ther 2002 303: 282-292. [Abstract] [Full Text] [PDF]  

Kristy L. West, Tripurasundari Ramjiganesh, Suheeta Roy, Bradley T. Keller, and Maria Luz Fernandez

1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane Methanesulfonate (SC-435), an Ileal Apical Sodium-Codependent Bile Acid Transporter Inhibitor Alters Hepatic Cholesterol Metabolism and Lowers Plasma Low-Density Lipoprotein-Cholesterol Concentrations in Guinea Pigs
J Pharmacol Exp Ther 2002 303: 293-299. [Abstract] [Full Text] [PDF]  

Chris Hague, Pedro J. Gonzalez-Cabrera, William B. Jeffries, and Peter W. Abel

Relationship between ₁-Adrenergic Receptor-Induced Contraction and Extracellular Signal-Regulated Kinase Activation in the Bovine Inferior Alveolar Artery
J Pharmacol Exp Ther 2002 303: 403-411. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

A. Banan, J. Z. Fields, A. Farhadi, D. A. Talmage, L. Zhang, and A. Keshavarzian

Activation of -Isoform of Protein Kinase C Is Required for Oxidant-Induced Disruption of Both the Microtubule Cytoskeleton and Permeability Barrier of Intestinal Epithelia
J Pharmacol Exp Ther 2002 303: 17-28. [Abstract] [Full Text] [PDF]  

Helena Denac, Meike Mevissen, Frank J. P. Kühn, Cornelia Kühn, Christophe T. Guionaud, Günter Scholtysik, and Nikolaus G. Greeff

Molecular Cloning and Functional Characterization of a Unique Mammalian Cardiac Na_v Channel Isoform with Low Sensitivity to the Synthetic Inactivation Inhibitor ()-(S)-6-Amino--[(4-diphenylmethyl-1-piperazinyl)-methyl]-9H-purine-9-ethanol (SDZ 211-939)
J Pharmacol Exp Ther 2002 303: 89-98. [Abstract] [Full Text] [PDF]  

Muxiang Zhou, Lubing Gu, Fengzhi Li, Yerun Zhu, William G. Woods, and Harry W. Findley

DNA Damage Induces a Novel p53-Survivin Signaling Pathway Regulating Cell Cycle and Apoptosis in Acute Lymphoblastic Leukemia Cells
J Pharmacol Exp Ther 2002 303: 124-131. [Abstract] [Full Text] [PDF]  

Hannah Ben-Bassat, Zipora Hartzstark, Rubina Levitzki, Benjamin Y. Klein, Zipora Shlomai, Aviv Gazit, and Alexander Levitzki

Tyrosine Kinase Inhibitors Suppress the Growth of Non-Hodgkin B Lymphomas
J Pharmacol Exp Ther 2002 303: 163-171. [Abstract] [Full Text] [PDF]  

Xiuxiang Jiao, Pedro J. Gonzalez-Cabrera, Lei Xiao, Michael E. Bradley, Peter W. Abel, and William B. Jeffries

Tonic Inhibitory Role for cAMP in _1a-Adrenergic Receptor Coupling to Extracellular Signal-Regulated Kinases 1/2
J Pharmacol Exp Ther 2002 303: 247-256. [Abstract] [Full Text] [PDF]  

Liqiang Ren and Peter J. Syapin

Dual Mechanisms for Ethanol-Induced Inhibition of Monocyte Chemotactic Protein-3 mRNA Expression in Activated Glial Cells
J Pharmacol Exp Ther 2002 303: 265-272. [Abstract] [Full Text] [PDF]  

Márcio A. F. de Godoy and Ana M. de Oliveira

Cross-Talk Between AT₁ and AT₂ Angiotensin Receptors in Rat Anococcygeus Smooth Muscle
J Pharmacol Exp Ther 2002 303: 333-339. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Peter Milberg, Lars Eckardt, Hans-Jürgen Bruns, Julia Biertz, Shahram Ramtin, Nico Reinsch, Dirk Fleischer, Paulus Kirchhof, Larissa Fabritz, Günter Breithardt, and Wilhelm Haverkamp

Divergent Proarrhythmic Potential of Macrolide Antibiotics Despite Similar QT Prolongation: Fast Phase 3 Repolarization Prevents Early Afterdepolarizations and Torsade de Pointes
J Pharmacol Exp Ther 2002 303: 218-225. [Abstract] [Full Text] [PDF]  

Fouad Brahimi, Stephanie L. Matheson, Fabienne Dudouit, James P. Mcnamee, Ana M. Tari, and Bertrand J. Jean-Claude

Inhibition of Epidermal Growth Factor Receptor-Mediated Signaling by "Combi-Triazene" BJ2000, a New Probe for Combi-Targeting Postulates
J Pharmacol Exp Ther 2002 303: 238-246. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Rajesh Amin, Hai-Qing Chen, Marie Tannous, Richard Gibbs, and Anjaneyulu Kowluru

Inhibition of Glucose- and Calcium-Induced Insulin Secretion from TC3 Cells by Novel Inhibitors of Protein Isoprenylation
J Pharmacol Exp Ther 2002 303: 82-88. [Abstract] [Full Text] [PDF]  

Elisabetta Galbiati, Paola Lorenza Caruso, Gabriele Amari, Elisabetta Armani, Silvia Ghirardi, Maurizio Delcanale, and Maurizio Civelli

Pharmacological Actions of a Novel, Potent, Tissue-Selective Benzopyran Estrogen
J Pharmacol Exp Ther 2002 303: 196-203. [Abstract] [Full Text] [PDF]  

Lisa M. Schrott, Mary Irene Baumgart, Xuewei Zhang, and Sheldon B. Sparber

Prenatal Opiate Withdrawal Activates the Chick Embryo Hypothalamic-Pituitary-Adrenal Axis and Dilates Vitelline Blood Vessels via Serotonin₂ Receptors
J Pharmacol Exp Ther 2002 303: 257-264. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Kunrong Cheng, Sandeep Khurana, Ying Chen, Richard H. Kennedy, Piotr Zimniak, and Jean-Pierre Raufman

Lithocholylcholine, a Bile Acid/Acetylcholine Hybrid, Is a Muscarinic Receptor Antagonist
J Pharmacol Exp Ther 2002 303: 29-35. [Abstract] [Full Text] [PDF]  

Sébastien J. Provencher and Marielle Gascon-Barré

Effect of Cyclosporine A on Hepatic Compensatory Growth: Role of Calcium Status
J Pharmacol Exp Ther 2002 303: 58-65. [Abstract] [Full Text] [PDF]  

Yasuharu Aki, Akira Nishiyama, Akira Miyatake, Shoji Kimura, Masakazu Kohno, and Youichi Abe

Role of Adenosine A₁ Receptor in Angiotensin II- and Norepinephrine-Induced Renal Vasoconstriction
J Pharmacol Exp Ther 2002 303: 117-123. [Abstract] [Full Text] [PDF]  

Shizuo Narimatsu, Chie Takemi, Daisuke Tsuzuki, Hiroyuki Kataoka, Shigeo Yamamoto, Noriaki Shimada, Satoshi Suzuki, Tetsuo Satoh, Urs A. Meyer, and Frank J. Gonzalez

Stereoselective Metabolism of Bufuralol Racemate and Enantiomers in Human Liver Microsomes
J Pharmacol Exp Ther 2002 303: 172-178. [Abstract] [Full Text] [PDF]  

Thomas E. N. Jonassen, Martin Græbe, Dominique Promeneur, Søren Nielsen, Sten Christensen, and Niels V. Olsen

Lipopolysaccharide-Induced Acute Renal Failure in Conscious Rats: Effects of Specific Phosphodiesterase Type 3 and 4 Inhibition
J Pharmacol Exp Ther 2002 303: 364-374. [Abstract] [Full Text] [PDF]  

Murali Gopalakrishnan, Steven A. Buckner, Kristi L. Whiteaker, Char-Chang Shieh, Eduardo J. Molinari, Ivan Milicic, Anthony V. Daza, Rachel Davis-Taber, Victoria E. Scott, Donna Sellers, Russ Chess-Williams, Christopher R. Chapple, Yi Liu, Dong Liu, Jorge D. Brioni, James P. Sullivan, Michael Williams, William A. Carroll, and Michael J. Coghlan

()-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. I. In Vitro Characterization
J Pharmacol Exp Ther 2002 303: 379-386. [Abstract] [Full Text] [PDF]  

Michael E. Brune, Thomas A. Fey, Jorge D. Brioni, James P. Sullivan, Michael Williams, William A. Carroll, Michael J. Coghlan, and Murali Gopalakrishnan

()-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. II. In Vivo Characterization
J Pharmacol Exp Ther 2002 303: 387-394. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Silvina Raiden, Karen Nahmod, Víctor Nahmod, Guillermo Semeniuk, Yanina Pereira, Clarisa Alvarez, Mirta Giordano, and Jorge R. Geffner

Nonpeptide Antagonists of AT1 Receptor for Angiotensin II Delay the Onset of Acute Respiratory Distress Syndrome
J Pharmacol Exp Ther 2002 303: 45-51. [Abstract] [Full Text] [PDF]  

Mari Ohtsuka, Fujiko Konno, Haruyoshi Honda, Takayuki Oikawa, Masago Ishikawa, Nobuhisa Iwase, Kazuo Isomae, Fumio Ishii, Hiromichi Hemmi, and Susumu Sato

PPA250 [3-(2,4-Difluorophenyl)-6-{2-[4-(1H-imidazol-1-ylmethyl) Phenoxy]ethoxy}-2-phenylpyridine], a Novel Orally Effective Inhibitor of the Dimerization of Inducible Nitric-Oxide Synthase, Exhibits an Anti-Inflammatory Effect in Animal Models of Chronic Arthritis
J Pharmacol Exp Ther 2002 303: 52-57. [Abstract] [Full Text] [PDF]  

Masahiko Hayashi, Mun-Chual Rho, Akiko Fukami, Akiko Enomoto, Shinobu Nonaka, Yoshino Sekiguchi, Tadashi Yanagisawa, Ayano Yamashita, Toshihiko Nogawa, Yoshiaki Kamano, and Kanki Komiyama

Biological Activity of a Novel Nonpeptide Antagonist to the Interleukin-6 Receptor 20S,21-Epoxy-resibufogenin-3-formate
J Pharmacol Exp Ther 2002 303: 104-109. [Abstract] [Full Text] [PDF]  

Giuseppe Molinaro, Massimo Cugno, Mélissa Perez, Yves Lepage, Nicole Gervais, Angelo Agostoni, and Albert Adam

Angiotensin-Converting Enzyme Inhibitor-Associated Angioedema Is Characterized by a Slower Degradation of des-Arginine⁹-Bradykinin
J Pharmacol Exp Ther 2002 303: 232-237. [Abstract] [Full Text] [PDF]  

Georgy Hartmann, Annie K. Y. Cheung, and Micheline Piquette-Miller

Inflammatory Cytokines, but Not Bile Acids, Regulate Expression of Murine Hepatic Anion Transporters in Endotoxemia
J Pharmacol Exp Ther 2002 303: 273-281. [Abstract] [Full Text] [PDF]  

Florian Gantner, Katsuya Sakai, Michael W. Tusche, William W. Cruikshank, David M. Center, and Kevin B. Bacon

Histamine H₄ and H₂ Receptors Control Histamine-Induced Interleukin-16 Release from Human CD8⁺ T Cells
J Pharmacol Exp Ther 2002 303: 300-307. [Abstract] [Full Text] [PDF]  

Rene Anikwue, John W. Huffman, Zachary L. Martin, and Sandra P. Welch

Decrease in Efficacy and Potency of Nonsteroidal Anti-Inflammatory Drugs by Chronic ⁹-Tetrahydrocannabinol Administration
J Pharmacol Exp Ther 2002 303: 340-346. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Laura J. Sim-Selley and Billy R. Martin

Effect of Chronic Administration of R-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone Mesylate (WIN55,212-2) or ⁹-Tetrahydrocannabinol on Cannabinoid Receptor Adaptation in Mice
J Pharmacol Exp Ther 2002 303: 36-44. [Abstract] [Full Text] [PDF]  

S. K. Hemrick-Luecke, F. P. Bymaster, D. C. Evans, J. Wess, and C. C. Felder

Muscarinic Agonist-Mediated Increases in Serum Corticosterone Levels Are Abolished in M₂ Muscarinic Acetylcholine Receptor Knockout Mice
J Pharmacol Exp Ther 2002 303: 99-103. [Abstract] [Full Text] [PDF]  

Michael F. Wilkemeyer, Carrie E. Menkari, Catherine Y. Spong, and Michael E. Charness

Peptide Antagonists of Ethanol Inhibition of L1-Mediated Cell-Cell Adhesion
J Pharmacol Exp Ther 2002 303: 110-116. [Abstract] [Full Text] [PDF]  

J. H. Chin, K. Harris, D. MacTavish, and J. H. Jhamandas

Nociceptin/Orphanin FQ Modulation of Ionic Conductances in Rat Basal Forebrain Neurons
J Pharmacol Exp Ther 2002 303: 188-195. [Abstract] [Full Text] [PDF]  

Md. Harunor Rashid and Hiroshi Ueda

Nonopioid and Neuropathy-Specific Analgesic Action of the Nootropic Drug Nefiracetam in Mice
J Pharmacol Exp Ther 2002 303: 226-231. [Abstract] [Full Text] [PDF]  

L. B. Hough, J. W. Nalwalk, R. Stadel, H. Timmerman, R. Leurs, B. C. Paria, X. Wang, and S. K. Dey

Inhibition of Improgan Antinociception by the Cannabinoid (CB)₁ Antagonist N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): Lack of Obligatory Role for Endocannabinoids Acting at CB₁ Receptors
J Pharmacol Exp Ther 2002 303: 314-322. [Abstract] [Full Text] [PDF]  

Susan A. Masino, Lihong Diao, Peter Illes, Nancy R. Zahniser, Gaynor A. Larson, Björn Johansson, Bertil B. Fredholm, and Thomas V. Dunwiddie

Modulation of Hippocampal Glutamatergic Transmission by ATP Is Dependent on Adenosine A₁ Receptors
J Pharmacol Exp Ther 2002 303: 356-363. [Abstract] [Full Text] [PDF]  

Khalid Benamar, Ellen B. Geller, and Martin W. Adler

Role of the Nitric Oxide Pathway in -Opioid-Induced Hypothermia in Rats
J Pharmacol Exp Ther 2002 303: 375-378. [Abstract] [Full Text] [PDF]  

S. M. Rawls, A. Cowan, R. J. Tallarida, Ellen B. Geller, and Martin W. Adler

N-Methyl-D-aspartate Antagonists and WIN 55212-2 [4,5-Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a Cannabinoid Agonist, Interact to Produce Synergistic Hypothermia
J Pharmacol Exp Ther 2002 303: 395-402. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Laura J. C. Bolchoz, Jason D. Morrow, David J. Jollow, and David C. McMillan

Primaquine-Induced Hemolytic Anemia: Effect of 6-Methoxy-8-hydroxylaminoquinoline on Rat Erythrocyte Sulfhydryl Status, Membrane Lipids, Cytoskeletal Proteins, and Morphology
J Pharmacol Exp Ther 2002 303: 141-148. [Abstract] [Full Text] [PDF]  

Maddison D. Harrell and Joseph R. Stimers

Differential Effects of Linoleic Acid Metabolites on Cardiac Sodium Current
J Pharmacol Exp Ther 2002 303: 347-355. [Abstract] [Full Text] [PDF]  

ASPET MEETING REPORT:

Martin C. Michel and Jorge D. Brioni

Meeting Report for the ASPET Ray Fuller Symposium: Lower Urinary Tract Disorders: Physiology, Pharmacology, and Therapeutic Approaches
J Pharmacol Exp Ther 2002 303: 431-437. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.