PERSPECTIVES IN PHARMACOLOGY:

Jennelle Durnett Richardson and Michael R. Vasko

Cellular Mechanisms of Neurogenic Inflammation
J Pharmacol Exp Ther 2002 302: 839-845. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

William A. Banks, Martin Goulet, James R. Rusche, Michael L. Niehoff, and Richard Boismenu

Differential Transport of a Secretin Analog across the Blood-Brain and Blood-Cerebrospinal Fluid Barriers of the Mouse
J Pharmacol Exp Ther 2002 302: 1062-1069. [Abstract] [Full Text] [PDF]  

Donna S. Cox, Kenneth R. Scott, Huanling Gao, and Natalie D. Eddington

Effect of P-Glycoprotein on the Pharmacokinetics and Tissue Distribution of Enaminone Anticonvulsants: Analysis by Population and Physiological Approaches
J Pharmacol Exp Ther 2002 302: 1096-1104. [Abstract] [Full Text] [PDF]  

Tsutomu Kotegawa, Bart E. Laurijssens, Lisa L. von Moltke, Monette M. Cotreau, Michael D. Perloff, Karthik Venkatakrishnan, Jill S. Warrington, Brian W. Granda, Jerold S. Harmatz, and David J. Greenblatt

In Vitro, Pharmacokinetic, and Pharmacodynamic Interactions of Ketoconazole and Midazolam in the Rat
J Pharmacol Exp Ther 2002 302: 1228-1237. [Abstract] [Full Text] [PDF]  

Rikiya Ohashi, Ikumi Tamai, Akihiro Inano, Masaki Katsura, Yoshimichi Sai, Jun-ichi Nezu, and Akira Tsuji

Studies on Functional Sites of Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) Using a Ser467Cys Mutant Protein
J Pharmacol Exp Ther 2002 302: 1286-1294. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Artur H. Swiergiel and Adrian J. Dunn

Distinct Roles for Cyclooxygenases 1 and 2 in Interleukin-1-Induced Behavioral Changes
J Pharmacol Exp Ther 2002 302: 1031-1036. [Abstract] [Full Text] [PDF]  

Shelli L. Kirstein, Kirsten L. Davidson, Marissa A. Ehringer, James M. Sikela, V. Gene Erwin, and Boris Tabakoff

Quantitative Trait Loci Affecting Initial Sensitivity and Acute Functional Tolerance to Ethanol-Induced Ataxia and Brain cAMP Signaling in BXD Recombinant Inbred Mice
J Pharmacol Exp Ther 2002 302: 1238-1245. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Lisa A. Badon, Alissa Hicks, Kevin Lord, Brian A. Ogden, Suzanne Meleg-Smith, and Kurt J. Varner

Changes in Cardiovascular Responsiveness and Cardiotoxicity Elicited during Binge Administration of Ecstasy
J Pharmacol Exp Ther 2002 302: 898-907. [Abstract] [Full Text] [PDF]  

Hélène C. Seegers, Richard W. Gross, and Walter A. Boyle

Calcium-Independent Phospholipase A₂-Derived Arachidonic Acid Is Essential for Endothelium-Dependent Relaxation by Acetylcholine
J Pharmacol Exp Ther 2002 302: 918-923. [Abstract] [Full Text] [PDF]  

Jun Katada, Michiko Muramatsu, Izumi Hayashi, Masahiro Tsutsumi, Yoichi Konishi, and Masataka Majima

Significance of Vascular Endothelial Cell Growth Factor Up-Regulation Mediated via a Chymase-Angiotensin-Dependent Pathway during Angiogenesis in Hamster Sponge Granulomas
J Pharmacol Exp Ther 2002 302: 949-956. [Abstract] [Full Text] [PDF]  

Marc P. Maillard, Christine Perregaux, Catherine Centeno, Joachim Stangier, Wolfgang Wienen, Hans-R. Brunner, and Michel Burnier

In Vitro and in Vivo Characterization of the Activity of Telmisartan: An Insurmountable Angiotensin II Receptor Antagonist
J Pharmacol Exp Ther 2002 302: 1089-1095. [Abstract] [Full Text] [PDF]  

Claus U. Niemann, Maythem Saeed, Haydar Akbari, Wolfgang Jacobsen, Leslie Z. Benet, Uwe Christians, and Natalie Serkova

Close Association Between the Reduction in Myocardial Energy Metabolism and Infarct Size: Dose-Response Assessment of Cyclosporine
J Pharmacol Exp Ther 2002 302: 1123-1128. [Abstract] [Full Text] [PDF]  

Monica I. Masana, Suzanne Doolen, Cagatay Ersahin, Walid M. Al-Ghoul, Sue Piper Duckles, Margarita L. Dubocovich, and Diana N. Krause

MT₂ Melatonin Receptors Are Present and Functional in Rat Caudal Artery
J Pharmacol Exp Ther 2002 302: 1295-1302. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Chang Yell Shin, Yul Pyo Lee, Tai Sang Lee, Hyun Dong Je, Dong Seok Kim, and Uy Dong Sohn

The Signal Transduction of Endothelin-1-Induced Circular Smooth Muscle Cell Contraction in Cat Esophagus
J Pharmacol Exp Ther 2002 302: 924-934. [Abstract] [Full Text] [PDF]  

Brian D. Stout, William P. Clarke, and Kelly A. Berg

Rapid Desensitization of the Serotonin_2C Receptor System: Effector Pathway and Agonist Dependence
J Pharmacol Exp Ther 2002 302: 957-962. [Abstract] [Full Text] [PDF]  

Dong Xu, Dongjiu Ye, Michael Fisher, and R. L. Juliano

Selective Inhibition of P-glycoprotein Expression in Multidrug-Resistant Tumor Cells by a Designed Transcriptional Regulator
J Pharmacol Exp Ther 2002 302: 963-971. [Abstract] [Full Text] [PDF]  

Bahjat Al-Ani, Suranga J. Wijesuriya, and Morley D. Hollenberg

Proteinase-Activated Receptor 2: Differential Activation of the Receptor by Tethered Ligand and Soluble Peptide Analogs
J Pharmacol Exp Ther 2002 302: 1046-1054. [Abstract] [Full Text] [PDF]  

Jeanette Wood, Karine Bonjean, Stephan Ruetz, Akeila Bellahcène, Laetitia Devy, Jean Michel Foidart, Vincent Castronovo, and Jonathan R. Green

Novel Antiangiogenic Effects of the Bisphosphonate Compound Zoledronic Acid
J Pharmacol Exp Ther 2002 302: 1055-1061. [Abstract] [Full Text] [PDF]  

Jing-Gen Liu and Paul L. Prather

Chronic Agonist Treatment Converts Antagonists into Inverse Agonists at -Opioid Receptors
J Pharmacol Exp Ther 2002 302: 1070-1079. [Abstract] [Full Text] [PDF]  

Juan J. Carrillo, Patricia A. Stevens, and Graeme Milligan

Measurement of Agonist-Dependent and -Independent Signal Initiation of _1b-Adrenoceptor Mutants by Direct Analysis of Guanine Nucleotide Exchange on the G Protein G₁₁
J Pharmacol Exp Ther 2002 302: 1080-1088. [Abstract] [Full Text] [PDF]  

Gilles Martin and George Robert Siggins

Electrophysiological Evidence for Expression of Glycine Receptors in Freshly Isolated Neurons from Nucleus Accumbens
J Pharmacol Exp Ther 2002 302: 1135-1145. [Abstract] [Full Text] [PDF]  

Fengqin Zhang, Jin Li, Jian-Guo Li, and Lee-Yuan Liu-Chen

()U50,488H [(trans)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] Induces Internalization and Down-Regulation of the Human, but not the Rat, -Opioid Receptor: Structural Basis for the Differential Regulation
J Pharmacol Exp Ther 2002 302: 1184-1192. [Abstract] [Full Text] [PDF]  

Melva Avalos, Michael J. Parker, Floyd N. Maddox, F. Ivy Carroll, and Charles W. Luetje

Effects of Pyridine Ring Substitutions on Affinity, Efficacy, and Subtype Selectivity of Neuronal Nicotinic Receptor Agonist Epibatidine
J Pharmacol Exp Ther 2002 302: 1246-1252. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Alan P. Robertson, Cheryl L. Clark, Teresa A. Burns, David P. Thompson, Timothy G. Geary, Sasa M. Trailovic, and Richard J. Martin

Paraherquamide and 2-Deoxy-paraherquamide Distinguish Cholinergic Receptor Subtypes in Ascaris Muscle
J Pharmacol Exp Ther 2002 302: 853-860. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Katsuya Morita, Akira Sakakibara, Shigeo Kitayama, Kei Kumagai, Kazuo Tanne, and Toshihiro Dohi

Pituitary Adenylate Cyclase-Activating Polypeptide Induces a Sustained Increase in Intracellular Free Ca²⁺ Concentration and Catecholamine Release by Activating Ca²⁺ Influx via Receptor-Stimulated Ca²⁺ Entry, Independent of Store-Operated Ca²⁺ Channels, and Voltage-Dependent Ca²⁺ Channels in Bovine Adrenal Medullary Chromaffin Cells
J Pharmacol Exp Ther 2002 302: 972-982. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Jean Pierre Faure, Thierry Hauet, Zeqiu Han, Jean Michel Goujon, Isabelle Petit, Gerard Mauco, Michel Eugene, Michel Carretier, and Vassilios Papadopoulos

Polyethylene Glycol Reduces Early and Long-Term Cold Ischemia-Reperfusion and Renal Medulla Injury
J Pharmacol Exp Ther 2002 302: 861-870. [Abstract] [Full Text] [PDF]  

B. R. Yerxa, J. R. Sabater, C. W. Davis, M. J. Stutts, M. Lang-Furr, M. Picher, A. C. Jones, M. Cowlen, R. Dougherty, J. Boyer, W. M. Abraham, and R. C. Boucher

Pharmacology of INS37217 [P¹-(Uridine 5')-P⁴- (2'-deoxycytidine 5')tetraphosphate, Tetrasodium Salt], a Next-Generation P2Y₂ Receptor Agonist for the Treatment of Cystic Fibrosis
J Pharmacol Exp Ther 2002 302: 871-880. [Abstract] [Full Text] [PDF]  

Xiaoping Zhou, Jim Ren, Erika Brown, David Schneider, Yessi Caraballo-Lopez, and James J. Galligan

Pharmacological Properties of Nicotinic Acetylcholine Receptors Expressed by Guinea Pig Small Intestinal Myenteric Neurons
J Pharmacol Exp Ther 2002 302: 889-897. [Abstract] [Full Text] [PDF]  

M. B. Bowen-Yacyshyn, C. F. Bennett, N. Nation, D. Rayner, and B. R. Yacyshyn

Amelioration of Chronic and Spontaneous Intestinal Inflammation with an Antisense Oligonucleotide (ISIS 9125) to Intracellular Adhesion Molecule-1 in the HLA-B27/2 Microglobulin Transgenic Rat Model
J Pharmacol Exp Ther 2002 302: 908-917. [Abstract] [Full Text] [PDF]  

Laurent Diop, Frederic Raymond, Helene Fargeau, Francine Petoux, Maria Chovet, and Annette M. Doherty

Pregabalin (CI-1008) Inhibits the Trinitrobenzene Sulfonic Acid-Induced Chronic Colonic Allodynia in the Rat
J Pharmacol Exp Ther 2002 302: 1013-1022. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Roma Kalra, Shashi P. Singh, Dean Kracko, Shannon G. Matta, Burt M. Sharp, and Mohan L. Sopori

Chronic Self-Administration of Nicotine in Rats Impairs T Cell Responsiveness
J Pharmacol Exp Ther 2002 302: 935-939. [Abstract] [Full Text] [PDF]  

Sandie Escotte, Claire Danel, Dominique Gaillard, Sylvie Benoit, Jacky Jacquot, Daniel Dusser, Jean-Michel Triglia, Caroline Majer-Teboul, and Edith Puchelle

Fluticasone Propionate Inhibits Lipopolysaccharide-Induced Proinflammatory Response in Human Cystic Fibrosis Airway Grafts
J Pharmacol Exp Ther 2002 302: 1151-1157. [Abstract] [Full Text] [PDF]  

Jugnu Jain, Susan J. Almquist, Angela D. Heiser, Dina Shlyakhter, Eduardo Leon, Christine Memmott, Cameron Stuver Moody, Elmar Nimmesgern, and Caroline Decker

Characterization of Pharmacological Efficacy of VX-148, a New, Potent Immunosuppressive Inosine 5'-Monophosphate Dehydrogenase Inhibitor
J Pharmacol Exp Ther 2002 302: 1272-1277. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Paola Ciceri, Yan Zhang, Alex F. Shaffer, Kathleen M. Leahy, Mark B. Woerner, Walter G. Smith, Karen Seibert, and Peter C. Isakson

Pharmacology of Celecoxib in Rat Brain after Kainate Administration
J Pharmacol Exp Ther 2002 302: 846-852. [Abstract] [Full Text] [PDF]  

TracyAnn Perry, Norman J. Haughey, Mark P. Mattson, Josephine M. Egan, and Nigel H. Greig

Protection and Reversal of Excitotoxic Neuronal Damage by Glucagon-Like Peptide-1 and Exendin-4
J Pharmacol Exp Ther 2002 302: 881-888. [Abstract] [Full Text] [PDF]  

R. Gill, A. Alanine, A. Bourson, B. Buttelmann, G. Fischer, M.-P. Heitz, J. N. C. Kew, B. Levet-Trafit, H.-P. Lorez, P. Malherbe, M.-T. Miss, V. Mutel, E. Pinard, S. Roever, M. Schmitt, G. Trube, R. Wybrecht, R. Wyler, and J. A. Kemp

Pharmacological Characterization of Ro 63-1908 (1-[2-(4-Hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a Novel Subtype-Selective N-Methyl-D-Aspartate Antagonist
J Pharmacol Exp Ther 2002 302: 940-948. [Abstract] [Full Text] [PDF]  

Steven T. Szabo and Pierre Blier

Effects of Serotonin (5-Hydroxytryptamine, 5-HT) Reuptake Inhibition Plus 5-HT_2A Receptor Antagonism on the Firing Activity of Norepinephrine Neurons
J Pharmacol Exp Ther 2002 302: 983-991. [Abstract] [Full Text] [PDF]  

Svetlana T. Mihaylova-Todorova, Latchezar D. Todorov, and David P. Westfall

Enzyme Kinetics and Pharmacological Characterization of Nucleotidases Released from the Guinea Pig Isolated Vas Deferens during Nerve Stimulation: Evidence for a Soluble Ecto-Nucleoside Triphosphate Diphosphohydrolase-Like ATPase and a Soluble Ecto-5'-Nucleotidase-Like AMPase
J Pharmacol Exp Ther 2002 302: 992-1001. [Abstract] [Full Text] [PDF]  

J. Mark Quillan, Kurt W. Carlson, Chunyan Song, Danxin Wang, and Wolfgang Sadée

Differential Effects of µ-Opioid Receptor Ligands on Ca²⁺ Signaling
J Pharmacol Exp Ther 2002 302: 1002-1012. [Abstract] [Full Text] [PDF]  

Rodney P. Guttmann, Set Sokol, Dana L. Baker, Kelly L. Simpkins, Yina Dong, and David R. Lynch

Proteolysis of the N-Methyl-D-Aspartate Receptor by Calpain in Situ
J Pharmacol Exp Ther 2002 302: 1023-1030. [Abstract] [Full Text] [PDF]  

J. E. Kralic, E. R. Korpi, T. K. O'Buckley, G. E. Homanics, and A. L. Morrow

Molecular and Pharmacological Characterization of GABA_A Receptor 1 Subunit Knockout Mice
J Pharmacol Exp Ther 2002 302: 1037-1045. [Abstract] [Full Text] [PDF]  

Guoping Cai, Hoau-Yan Wang, and Eitan Friedman

Increased Dopamine Receptor Signaling and Dopamine Receptor-G Protein Coupling in Denervated Striatum
J Pharmacol Exp Ther 2002 302: 1105-1112. [Abstract] [Full Text] [PDF]  

Dennis K. Miller, Sangeetha P. Sumithran, and Linda P. Dwoskin

Bupropion Inhibits Nicotine-Evoked [³H]Overflow from Rat Striatal Slices Preloaded with [³H]Dopamine and from Rat Hippocampal Slices Preloaded with [³H]Norepinephrine
J Pharmacol Exp Ther 2002 302: 1113-1122. [Abstract] [Full Text] [PDF]  

S. Kapur, X. Langlois, P. Vinken, A. A. H. P. Megens, R. De Coster, and J. S. Andrews

The Differential Effects of Atypical Antipsychotics on Prolactin Elevation Are Explained by Their Differential Blood-Brain Disposition: A Pharmacological Analysis in Rats
J Pharmacol Exp Ther 2002 302: 1129-1134. [Abstract] [Full Text] [PDF]  

K. A. Sluka, J. J. Rohlwing, R. A. Bussey, S. A. Eikenberry, and J. M. Wilken

Chronic Muscle Pain Induced by Repeated Acid Injection Is Reversed by Spinally Administered µ- and -, but Not -, Opioid Receptor Agonists
J Pharmacol Exp Ther 2002 302: 1146-1150. [Abstract] [Full Text] [PDF]  

S. A. G. Visser, C. J. G. M. Smulders, B. P. R. Reijers, P. H. van der Graaf, L. A. Peletier, and M. Danhof

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of Concentration-Dependent Hysteresis and Biphasic Electroencephalogram Effects of Alphaxalone in Rats
J Pharmacol Exp Ther 2002 302: 1158-1167. [Abstract] [Full Text] [PDF]  

Tinna M. Laughlin, Kevin V. Tram, George L. Wilcox, and Angela K. Birnbaum

Comparison of Antiepileptic Drugs Tiagabine, Lamotrigine, and Gabapentin in Mouse Models of Acute, Prolonged, and Chronic Nociception
J Pharmacol Exp Ther 2002 302: 1168-1175. [Abstract] [Full Text] [PDF]  

Jacqueline Scuvee-Moreau, Jean-François Liegeois, Laurent Massotte, and Vincent Seutin

Methyl-Laudanosine: A New Pharmacological Tool to Investigate the Function of Small-Conductance Ca²⁺-Activated K⁺ Channels
J Pharmacol Exp Ther 2002 302: 1176-1183. [Abstract] [Full Text] [PDF]  

Li Zhu, Kresimir Krnjevi, Zhenghlin Jiang, Joseph J. McArdle, and Jiang Hong Ye

Ethanol Suppresses Fast Potentiation of Glycine Currents by Glutamate
J Pharmacol Exp Ther 2002 302: 1193-1200. [Abstract] [Full Text] [PDF]  

Jilla Sabeti, Greg A. Gerhardt, and Nancy R. Zahniser

Acute Cocaine Differentially Alters Accumbens and Striatal Dopamine Clearance in Low and High Cocaine Locomotor Responders: Behavioral and Electrochemical Recordings in Freely Moving Rats
J Pharmacol Exp Ther 2002 302: 1201-1211. [Abstract] [Full Text] [PDF]  

Yuxin Liu, Liya Qin, Belinda C. Wilson, Lijia An, Jau-Shyong Hong, and Bin Liu

Inhibition by Naloxone Stereoisomers of -Amyloid Peptide (1-42)-induced Superoxide Production in Microglia and Degeneration of Cortical and Mesencephalic Neurons
J Pharmacol Exp Ther 2002 302: 1212-1219. [Abstract] [Full Text] [PDF]  

Michelle E. Page, John F. Cryan, Arthur Sullivan, Ashutosh Dalvi, Berangere Saucy, David R. Manning, and Irwin Lucki

Behavioral and Neurochemical Effects of 5-{4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide (EMD 68843): A Combined Selective Inhibitor of Serotonin Reuptake and 5-Hydroxytryptamine_1A Receptor Partial Agonist
J Pharmacol Exp Ther 2002 302: 1220-1227. [Abstract] [Full Text] [PDF]  

Alexis K. Baker and Theo F. Meert

Functional Effects of Systemically Administered Agonists and Antagonists of µ, , and Opioid Receptor Subtypes on Body Temperature in Mice
J Pharmacol Exp Ther 2002 302: 1253-1264. [Abstract] [Full Text] [PDF]  

Laura Cardenas, Lescia K. Tremblay, Claudio A. Naranjo, Nathan Herrmann, Martin Zack, and Usoa E. Busto

Brain Reward System Activity in Major Depression and Comorbid Nicotine Dependence
J Pharmacol Exp Ther 2002 302: 1265-1271. [Abstract] [Full Text] [PDF]  

W. P. Revill, J. Voda, C. R. Reeves, L. Chung, A. Schirmer, G. Ashley, J. R. Carney, M. Fardis, C. W. Carreras, Y. Zhou, L. Feng, E. Tucker, D. Robinson, and B. G. Gold

Genetically Engineered Analogs of Ascomycin for Nerve Regeneration
J Pharmacol Exp Ther 2002 302: 1278-1285. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Presynaptic Muscarinic M²-Receptor-Mediated Inhibition of N-Type Ca²⁺ Channels in Cultured Sphenopalatine Ganglion: Direct Evidence for Acetylcholine Inhibition of Cerebral Nitrergic Neurogenic Vasodilation"
J Pharmacol Exp Ther 2002 302: 1303. [Full Text] [PDF]  

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