PERSPECTIVES IN PHARMACOLOGY:

Phillip M. Gerk and Mary Vore

Regulation of Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) and Its Role in Drug Disposition
J Pharmacol Exp Ther 2002 302: 407-415. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Georgia J. Pass, Walter Becker, Reinhart Kluge, Katharina Linnartz, Leona Plum, Kirsten Giesen, and Hans-Georg Joost

Effect of Hyperinsulinemia and Type 2 Diabetes-Like Hyperglycemia on Expression of Hepatic Cytochrome P450 and Glutathione S-Transferase Isoforms in a New Zealand Obese-Derived Mouse Backcross Population
J Pharmacol Exp Ther 2002 302: 442-450. [Abstract] [Full Text] [PDF]  

Judy L. Raucy, Lisa Mueller, Kui Duan, Scott W. Allen, Stephen Strom, and Jerome M. Lasker

Expression and Induction of CYP2C P450 Enzymes in Primary Cultures of Human Hepatocytes
J Pharmacol Exp Ther 2002 302: 475-482. [Abstract] [Full Text] [PDF]  

Yukio Kato, Kiyoka Kuge, Hiroyuki Kusuhara, Peter J. Meier, and Yuichi Sugiyama

Gender Difference in the Urinary Excretion of Organic Anions in Rats
J Pharmacol Exp Ther 2002 302: 483-489. [Abstract] [Full Text] [PDF]  

De-Sheng Wang, Johan W. Jonker, Yukio Kato, Hiroyuki Kusuhara, Alfred H. Schinkel, and Yuichi Sugiyama

Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin
J Pharmacol Exp Ther 2002 302: 510-515. [Abstract] [Full Text] [PDF]  

Wonku Kang and Michael Weiss

Digoxin Uptake, Receptor Heterogeneity, and Inotropic Response in the Isolated Rat Heart: A Comprehensive Kinetic Model
J Pharmacol Exp Ther 2002 302: 577-583. [Abstract] [Full Text] [PDF]  

Michael J. Avram, Tom C. Krejcie, and Thomas K. Henthorn

The Concordance of Early Antipyrine and Thiopental Distribution Kinetics
J Pharmacol Exp Ther 2002 302: 594-600. [Abstract] [Full Text] [PDF]  

Martin K. Bijsterbosch, Muthiah Manoharan, Rick Dorland, Richard van Veghel, Erik A. L. Biessen, and Theo J. C. van Berkel

bis-Cholesteryl-Conjugated Phosphorothioate Oligodeoxynucleotides Are Highly Selectively Taken Up by the Liver
J Pharmacol Exp Ther 2002 302: 619-626. [Abstract] [Full Text] [PDF]  

Rajinder K. Bhardwaj, Hartmut Glaeser, Laurent Becquemont, Ulrich Klotz, Suresh K. Gupta, and Martin F. Fromm

Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4
J Pharmacol Exp Ther 2002 302: 645-650. [Abstract] [Full Text] [PDF]  

Michio Takeda, Suparat Khamdang, Shinichi Narikawa, Hiroaki Kimura, Makoto Hosoyamada, Seok Ho Cha, Takashi Sekine, and Hitoshi Endou

Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters
J Pharmacol Exp Ther 2002 302: 666-671. [Abstract] [Full Text] [PDF]  

G. F. Clough, P. Boutsiouki, M. K. Church, and C. C. Michel

Effects of Blood Flow on the in Vivo Recovery of a Small Diffusible Molecule by Microdialysis in Human Skin
J Pharmacol Exp Ther 2002 302: 681-686. [Abstract] [Full Text] [PDF]  

Celine Veau, Laurence Faivre, Sylviane Tardivel, Mireille Soursac, Helene Banide, Bernard Lacour, and Robert Farinotti

Effect of Interleukin-2 on Intestinal P-glycoprotein Expression and Functionality in Mice
J Pharmacol Exp Ther 2002 302: 742-750. [Abstract] [Full Text] [PDF]  

Takashi Nozawa, Miki Nakajima, Ikumi Tamai, Kumiko Noda, Jun-ichi Nezu, Yoshimichi Sai, Akira Tsuji, and Tsuyoshi Yokoi

Genetic Polymorphisms of Human Organic Anion Transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele Frequencies in the Japanese Population and Functional Analysis
J Pharmacol Exp Ther 2002 302: 804-813. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Alicia M. Crissman and James M. O'Donnell

Effects of Antidepressants in Rats Trained to Discriminate Centrally Administered Isoproterenol
J Pharmacol Exp Ther 2002 302: 606-611. [Abstract] [Full Text] [PDF]  

Paul C. Moser, Olivier E. Bergis, Samir Jegham, Alistair Lochead, Elee Duconseille, Jean-Paul Terranova, Dominique Caille, Isabelle Berque-Bestel, Frank Lezoualc'h, Rodolphe Fischmeister, Aline Dumuis, Joel Bockaert, Pascal George, Philippe Soubrié, and Bernard Scatton

SL65.0155, A Novel 5-Hydroxytryptamine₄ Receptor Partial Agonist with Potent Cognition-Enhancing Properties
J Pharmacol Exp Ther 2002 302: 731-741. [Abstract] [Full Text] [PDF]  

Per Plenge, Erling T. Mellerup, and Gitta Wörtwein

Characterization of Epibatidine Binding to Medial Habenula: Potential Role in Analgesia
J Pharmacol Exp Ther 2002 302: 759-765. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Charles Plut, Catherine Ribiere, Yves Giudicelli, and Jean-Pierre Dausse

Gender Differences in Hypothalamic Tyrosine Hydroxylase and ₂-Adrenoceptor Subtype Gene Expression in Cafeteria Diet-Induced Hypertension and Consequences of Neonatal Androgenization
J Pharmacol Exp Ther 2002 302: 525-531. [Abstract] [Full Text] [PDF]  

Nahid Seyedi, Motohiro Koyama, Christina J. Mackins, and Roberto Levi

Ischemia Promotes Renin Activation and Angiotensin Formation in Sympathetic Nerve Terminals Isolated from the Human Heart: Contribution to Carrier-Mediated Norepinephrine Release
J Pharmacol Exp Ther 2002 302: 539-544. [Abstract] [Full Text] [PDF]  

Christine P. Williams, NingNing Hu, Wangzhen Shen, Amy B. Mashburn, and Katherine T. Murray

Modulation of the Human Kv1.5 Channel by Protein Kinase C Activation: Role of the Kv1.2 Subunit
J Pharmacol Exp Ther 2002 302: 545-550. [Abstract] [Full Text] [PDF]  

Dayuan Li, Hongjiang Chen, Francesco Romeo, Tatsuya Sawamura, Tom Saldeen, and Jawahar L. Mehta

Statins Modulate Oxidized Low-Density Lipoprotein-Mediated Adhesion Molecule Expression in Human Coronary Artery Endothelial Cells: Role of LOX-1
J Pharmacol Exp Ther 2002 302: 601-605. [Abstract] [Full Text] [PDF]  

Yashu Coe, Stephen J. Haleen, Kathleen M. Welch, You-An Liu, and Flavio Coceani

The Endothelin A Receptor Antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) Reverse the Hypoxic Pulmonary Vasoconstriction in the Perinatal Lamb
J Pharmacol Exp Ther 2002 302: 672-680. [Abstract] [Full Text] [PDF]  

Hantz Hercule and Adebayo Oyekan

Renal Cytochrome P450 Oxygenases and Preglomerular Vascular Response to Arachidonic Acid and Endothelin-1 Following Ischemia/Reperfusion
J Pharmacol Exp Ther 2002 302: 717-724. [Abstract] [Full Text] [PDF]  

Jason P. Hannon, Bruno Tigani, Henk-Jan Schuurman, and John R. Fozard

Suppression of Adenosine A₃ Receptor-Mediated Hypotension and Mast Cell Degranulation in the Rat by Dexamethasone
J Pharmacol Exp Ther 2002 302: 725-730. [Abstract] [Full Text] [PDF]  

Martin Steinmetz, Ann-Kathrin Janssen, Franz Pelster, Karl Heinz Rahn, and Eberhard Schlatter

Vasoactivity of Diadenosine Polyphosphates in Human Small Mesenteric Resistance Arteries
J Pharmacol Exp Ther 2002 302: 787-794. [Abstract] [Full Text] [PDF]  

Anthony A. Fossa, Michael J. DePasquale, David L. Raunig, Michael J. Avery, and Derek J. Leishman

The Relationship of Clinical QT Prolongation to Outcome in the Conscious Dog Using a Beat-to-Beat QT-RR Interval Assessment
J Pharmacol Exp Ther 2002 302: 828-833. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Armen Mirzoian and Charles W. Luetje

Modulation of Neuronal Nicotinic Acetylcholine Receptors by Mercury
J Pharmacol Exp Ther 2002 302: 560-567. [Abstract] [Full Text] [PDF]  

Mark W. Fleck

Molecular Actions of (S)-Desmethylzopiclone (SEP-174559), an Anxiolytic Metabolite of Zopiclone
J Pharmacol Exp Ther 2002 302: 612-618. [Abstract] [Full Text] [PDF]  

Siew Peng Ho, Michael S. Scully, Candice M. Krauthauser, Eric J. Wexler, Mark D. Stow, Joseph E. Dinchuk, Janet S. Kerr, and Paul A. Friedman

Antisense Oligonucleotides Selectively Regulate Aspartyl -Hydroxylase and Its Truncated Protein Isoform in Vitro but Distribute Poorly into A549 Tumors in Vivo
J Pharmacol Exp Ther 2002 302: 795-803. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Antje Kaufhold, Prabhat K. Nigam, Ravindra N. Dhir, and Bernard H. Shapiro

Prevention of Latently Expressed CYP2C11, CYP3A2, and Growth Hormone Defects in Neonatally Monosodium Glutamate-Treated Male Rats by the N-Methyl-D-Aspartate Receptor Antagonist Dizocilpine Maleate
J Pharmacol Exp Ther 2002 302: 490-496. [Abstract] [Full Text] [PDF]  

Ludger M. Ickenstein and Stelvio M. Bandiera

Persistent Suppression of Hepatic CYP2A1 Expression and Serum Triiodothyronine Levels by Tamoxifen in Intact Female Rats: Dose-Response Analysis and Comparison with 4-Hydroxytamoxifen, Fulvestrant (ICI 182,780), and 17-Estradiol-3-benzoate
J Pharmacol Exp Ther 2002 302: 584-593. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Atsuko Fukada, Hideyuki Saito, and Ken-ichi Inui

Transport Mechanisms of Nicotine across the Human Intestinal Epithelial Cell Line Caco-2
J Pharmacol Exp Ther 2002 302: 532-538. [Abstract] [Full Text] [PDF]  

Lu Liu, Fei Shang, Irit Markus, and Elizabeth Burcher

Roles of Substance P Receptors in Human Colon Circular Muscle: Alterations in Diverticular Disease
J Pharmacol Exp Ther 2002 302: 627-635. [Abstract] [Full Text] [PDF]  

Ruth Weiss, Meike Mevissen, Daniela S. Hauser, Günter Scholtysik, Christopher J. Portier, Bernhard Walter, Urs E. Studer, and Hansjörg Danuser

Inhibition of Human and Pig Ureter Motility in Vitro and in Vivo by the K⁺ Channel Openers PKF 217-744b and Nicorandil
J Pharmacol Exp Ther 2002 302: 651-658. [Abstract] [Full Text] [PDF]  

D. Torrents, R. Torres, F. de Mora, and P. Vergara

Antinerve Growth Factor Treatment Prevents Intestinal Dysmotility in Trichinella spiralis-Infected Rats
J Pharmacol Exp Ther 2002 302: 659-665. [Abstract] [Full Text] [PDF]  

Toby J. Toward and Kenneth J. Broadley

Goblet Cell Hyperplasia, Airway Function, and Leukocyte Infiltration after Chronic Lipopolysaccharide Exposure in Conscious Guinea Pigs: Effects of Rolipram and Dexamethasone
J Pharmacol Exp Ther 2002 302: 814-821. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Robert J. McKallip, Catherine Lombard, Billy R. Martin, Mitzi Nagarkatti, and Prakash S. Nagarkatti

⁹-Tetrahydrocannabinol-Induced Apoptosis in the Thymus and Spleen as a Mechanism of Immunosuppression in Vitro and in Vivo
J Pharmacol Exp Ther 2002 302: 451-465. [Abstract] [Full Text] [PDF]  

Grant R. Stenton, Osamu Nohara, René E. Déry, Harissios Vliagoftis, Mark Gilchrist, Ankur Johri, John L. Wallace, Morley D. Hollenberg, Redwan Moqbel, and A. Dean Befus

Proteinase-Activated Receptor (PAR)-1 and -2 Agonists Induce Mediator Release from Mast Cells by Pathways Distinct from PAR-1 and PAR-2
J Pharmacol Exp Ther 2002 302: 466-474. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Marion Wittmann, Michael J. Marino, and P. Jeffrey Conn

Dopamine Modulates the Function of Group II and Group III Metabotropic Glutamate Receptors in the Substantia Nigra Pars Reticulata
J Pharmacol Exp Ther 2002 302: 433-441. [Abstract] [Full Text] [PDF]  

Jeffrey M. Brown, Evan L. Riddle, Verónica Sandoval, Raul K. Weston, Jarom E. Hanson, Michael J. Crosby, Yvette V. Ugarte, James W. Gibb, Glen R. Hanson, and Annette E. Fleckenstein

A Single Methamphetamine Administration Rapidly Decreases Vesicular Dopamine Uptake
J Pharmacol Exp Ther 2002 302: 497-501. [Abstract] [Full Text] [PDF]  

Chitra D. Mandyam, Deepak R. Thakker, Jennifer L. Christensen, and Kelly M. Standifer

Orphanin FQ/Nociceptin-Mediated Desensitization of Opioid Receptor-Like 1 Receptor and µ Opioid Receptors Involves Protein Kinase C: A Molecular Mechanism for Heterologous Cross-Talk
J Pharmacol Exp Ther 2002 302: 502-509. [Abstract] [Full Text] [PDF]  

Ryan K. Bachtell, Natalia O. Tsivkovskaia, and Andrey E. Ryabinin

Alcohol-Induced c-Fos Expression in the Edinger-Westphal Nucleus: Pharmacological and Signal Transduction Mechanisms
J Pharmacol Exp Ther 2002 302: 516-524. [Abstract] [Full Text] [PDF]  

Elvan Djouma and Andrew J. Lawrence

The Effect of Chronic Ethanol Consumption and Withdrawal on µ-Opioid and Dopamine D₁ and D₂ Receptor Density in Fawn-Hooded Rat Brain
J Pharmacol Exp Ther 2002 302: 551-559. [Abstract] [Full Text] [PDF]  

Timothy D. Moran and Peter A. Smith

Morphine-3-D-glucuronide Suppresses Inhibitory Synaptic Transmission in Rat Substantia Gelatinosa
J Pharmacol Exp Ther 2002 302: 568-576. [Abstract] [Full Text] [PDF]  

H. Steve White, Alan Sarup, Tina Bolvig, Anders S. Kristensen, Gitte Petersen, Nathan Nelson, Darryl S. Pickering, Orla M. Larsson, Bente Frølund, Povl Krogsgaard-Larsen, and Arne Schousboe

Correlation between Anticonvulsant Activity and Inhibitory Action on Glial -Aminobutyric Acid Uptake of the Highly Selective Mouse -Aminobutyric Acid Transporter 1 Inhibitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and Its N-Alkylated Analogs
J Pharmacol Exp Ther 2002 302: 636-644. [Abstract] [Full Text] [PDF]  

Dennis K. Miller, Erik H. F. Wong, M. Dathan Chesnut, and Linda P. Dwoskin

Reboxetine: Functional Inhibition of Monoamine Transporters and Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 2002 302: 687-695. [Abstract] [Full Text] [PDF]  

A. A. H. P. Megens, D. Ashton, J. C. A. Vermeire, P. C. M. Vermote, K. A. Hens, L. C. Hillen, J. F. Fransen, M. Mahieu, L. Heylen, J. E. Leysen, M. R. Jurzak, and F. Janssens

Pharmacological Profile of (2R-trans)-4-[1-[3,5-bis(Trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an Orally and Centrally Active Neurokinin-1 Receptor Antagonist
J Pharmacol Exp Ther 2002 302: 696-709. [Abstract] [Full Text] [PDF]  

Hong Sun, Maryann L. Shen, Yuan-Ping Pang, Oksana Lockridge, and Stephen Brimijoin

Cocaine Metabolism Accelerated by a Re-Engineered Human Butyrylcholinesterase
J Pharmacol Exp Ther 2002 302: 710-716. [Abstract] [Full Text] [PDF]  

Laurence Maulon-Feraille, Odile Della Zuana, Thomas Suply, Carole Rovere-Jovene, Valérie Audinot, Nigel Levens, Jean A. Boutin, Jacques Duhault, and Jean-Louis Nahon

Appetite-Boosting Property of Pro-Melanin-Concentrating Hormone_131-165 (Neuropeptide-Glutamic Acid-Isoleucine) Is Associated with Proteolytic Resistance
J Pharmacol Exp Ther 2002 302: 766-773. [Abstract] [Full Text] [PDF]  

G. Fábián, B. Bozó, M. Szikszay, G. Horváth, C. J. Coscia, and M. Szücs

Chronic Morphine-Induced Changes in µ-Opioid Receptors and G Proteins of Different Subcellular Loci in Rat Brain
J Pharmacol Exp Ther 2002 302: 774-780. [Abstract] [Full Text] [PDF]  

William A. Banks, Matthias Tschöp, Sandra M. Robinson, and Mark L. Heiman

Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure
J Pharmacol Exp Ther 2002 302: 822-827. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Xiuling Zhang, Ting Su, Qing-Yu Zhang, Jun Gu, Michele Caggana, Hongming Li, and Xinxin Ding

Genetic Polymorphisms of the Human CYP2A13 Gene: Identification of Single-Nucleotide Polymorphisms and Functional Characterization of an Arg257Cys Variant
J Pharmacol Exp Ther 2002 302: 416-423. [Abstract] [Full Text] [PDF]  

Shuangqing Peng, Ravindra K. Hajela, and William D. Atchison

Effects of Methylmercury on Human Neuronal L-Type Calcium Channels Transiently Expressed in Human Embryonic Kidney Cells (HEK-293)
J Pharmacol Exp Ther 2002 302: 424-432. [Abstract] [Full Text] [PDF]  

Ellen G. Duysen, Cynthia F. Bartels, and Oksana Lockridge

Wild-Type and A328W Mutant Human Butyrylcholinesterase Tetramers Expressed in Chinese Hamster Ovary Cells Have a 16-Hour Half-Life in the Circulation and Protect Mice from Cocaine Toxicity
J Pharmacol Exp Ther 2002 302: 751-758. [Abstract] [Full Text] [PDF]  

John Weaver, Supatra Porasuphatana, Pei Tsai, Guan-Liang Cao, Theodore A. Budzichowski, Linda J. Roman, and Gerald M. Rosen

The Activation of Neuronal Nitric-Oxide Synthase by Various Divalent Cations
J Pharmacol Exp Ther 2002 302: 781-786. [Abstract] [Full Text] [PDF]  

ERRATA:

Corrections to "July 2002 Table of Contents"
J Pharmacol Exp Ther 2002 302: 834. [Full Text] [PDF]  

Correction to "Characterization of the Transport Properties of Organic Anion Transporting Polypeptide 1 (oatp1) and Na⁺/Taurocholate Cotransporting Polypeptide (Ntcp): Comparative Studies on the Inhibitory Effect of Their Possible Substrates in Hepatocytes and cDNA-Transfected COS-7 Cells"
J Pharmacol Exp Ther 2002 302: 835. [Full Text] [PDF]  

Correction to "Clocinnamox Distinguishes Opioid Agonists According to Relative Efficacy in Normal and Morphine-Treated Rats Trained to Discriminate Morphine"
J Pharmacol Exp Ther 2002 302: 836. [Full Text] [PDF]  

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