PERSPECTIVES IN PHARMACOLOGY:

Val J. Watts

Molecular Mechanisms for Heterologous Sensitization of Adenylate Cyclase
J Pharmacol Exp Ther 2002 302: 1-7. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Jun-Sheng Wang, Xia Wen, Janne T. Backman, and Pertti J. Neuvonen

Effect of Albumin and Cytosol on Enzyme Kinetics of Tolbutamide Hydroxylation and on Inhibition of CYP2C9 by Gemfibrozil in Human Liver Microsomes
J Pharmacol Exp Ther 2002 302: 43-49. [Abstract] [Full Text] [PDF]  

Jean-Francois Marier, Pascal Vachon, Ari Gritsas, Jie Zhang, Jean-Pierre Moreau, and Murray P. Ducharme

Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model
J Pharmacol Exp Ther 2002 302: 369-373. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Ken-ichi Ueno, Hiroko Togashi, Machiko Matsumoto, Satoshi Ohashi, Hideya Saito, and Mitsuhiro Yoshioka

42 Nicotinic Acetylcholine Receptor Activation Ameliorates Impairment of Spontaneous Alternation Behavior in Stroke-Prone Spontaneously Hypertensive Rats, an Animal Model of Attention Deficit Hyperactivity Disorder
J Pharmacol Exp Ther 2002 302: 95-100. [Abstract] [Full Text] [PDF]  

Ellen A. Walker and Alice M. Young

Clocinnamox Distinguishes Opioid Agonists According to Relative Efficacy in Normal and Morphine-Treated Rats Trained to Discriminate Morphine
J Pharmacol Exp Ther 2002 302: 101-110. [Abstract] [Full Text] [PDF]  

Igor Ponomarev and John C. Crabbe

A Novel Method to Assess Initial Sensitivity and Acute Functional Tolerance to Hypnotic Effects of Ethanol
J Pharmacol Exp Ther 2002 302: 257-263. [Abstract] [Full Text] [PDF]  

Carrie A. Bowen, Bradford D. Fischer, Nancy K. Mello, and S. Stevens Negus

Antagonism of the Antinociceptive and Discriminative Stimulus Effects of Heroin and Morphine by 3-Methoxynaltrexone and Naltrexone in Rhesus Monkeys
J Pharmacol Exp Ther 2002 302: 264-273. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Francisco Pérez-Vizcaíno, Manuel Ibarra, Angel L. Cogolludo, Juan Duarte, Francisco Zaragozá-Arnáez, Laura Moreno, Gustavo López-López, and Juan Tamargo

Endothelium-Independent Vasodilator Effects of the Flavonoid Quercetin and Its Methylated Metabolites in Rat Conductance and Resistance Arteries
J Pharmacol Exp Ther 2002 302: 66-72. [Abstract] [Full Text] [PDF]  

Koji Kajiwara, Toshihiko Yanagita, Yasuhide Nakashima, Akihiko Wada, Futoshi Izumi, and Nobuyuki Yanagihara

Differential Effects of Short and Prolonged Exposure to Carvedilol on Voltage-Dependent Na⁺ Channels in Cultured Bovine Adrenal Medullary Cells
J Pharmacol Exp Ther 2002 302: 212-218. [Abstract] [Full Text] [PDF]  

Núria Roglans, Elena Sanguino, Cristina Peris, Marta Alegret, Manuel Vázquez, Tomás Adzet, Cristina Díaz, Gonzalo Hernández, Juan C. Laguna, and Rosa M. Sánchez

Atorvastatin Treatment Induced Peroxisome Proliferator-Activated Receptor Expression and Decreased Plasma Nonesterified Fatty Acids and Liver Triglyceride in Fructose-Fed Rats
J Pharmacol Exp Ther 2002 302: 232-239. [Abstract] [Full Text] [PDF]  

Joseph J. Lynch, Jr., Joseph J. Salata, Audrey A. Wallace, Gary L. Stump, David B. Gilberto, Hossain Jahansouz, Nigel J. Liverton, Harold G. Selnick, and David A. Claremon

Antiarrhythmic Efficacy of Combined I_Ks and -Adrenergic Receptor Blockade
J Pharmacol Exp Ther 2002 302: 283-289. [Abstract] [Full Text] [PDF]  

Jin-Bong Park, Han Choe, Yu-Kyung Lee, Ki-Chan Ha, Kyoung-Suk Rhee, Jae-Ki Ko, Chan-Uhng Joo, Soo-Wan Chae, and Yong-Geun Kwak

Open Channel Block by KCB-328 [1-(2-Amino-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane Hydrochloride] of the Heterologously Expressed Human Ether-a-go-go-Related Gene K⁺ Channels
J Pharmacol Exp Ther 2002 302: 314-319. [Abstract] [Full Text] [PDF]  

Satomi Kagota, Akiko Tamashiro, Yu Yamaguchi, Kazuki Nakamura, and Masaru Kunitomo

High Salt Intake Impairs Vascular Nitric Oxide/Cyclic Guanosine Monophosphate System in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2002 302: 344-351. [Abstract] [Full Text] [PDF]  

J. Liu, M. S. Evans, and T. J.-F. Lee

Presynaptic Muscarinic M₂-Receptor-Mediated Inhibition of N-Type Ca²⁺ Channels in Cultured Sphenopalatine Ganglion: Direct Evidence for Acetylcholine Inhibition of Cerebral Nitrergic Neurogenic Vasodilation
J Pharmacol Exp Ther 2002 302: 397-405. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Aleksandra Vicentic, Anna Robeva, George Rogge, Michelle Uberti, and Kenneth P. Minneman

Biochemistry and Pharmacology of Epitope-Tagged ₁-Adrenergic Receptor Subtypes
J Pharmacol Exp Ther 2002 302: 58-65. [Abstract] [Full Text] [PDF]  

Marina S. Feschenko, Elizabeth Stevenson, Angus C. Nairn, and Kathleen J. Sweadner

A Novel cAMP-Stimulated Pathway in Protein Phosphatase 2A Activation
J Pharmacol Exp Ther 2002 302: 111-118. [Abstract] [Full Text] [PDF]  

M. Motasim Billah, Nicola Cooper, Michael Minnicozzi, Julie Warneck, Peng Wang, John A. Hey, William Kreutner, Charles A. Rizzo, Sidney R. Smith, Simon Young, Richard W. Chapman, Hazel Dyke, Nang-Yang Shih, John J. Piwinski, Francis M. Cuss, John Montana, Ashit K. Ganguly, and Robert W. Egan

Pharmacology of N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline Carboxamide (SCH 351591), a Novel, Orally Active Phosphodiesterase 4 Inhibitor
J Pharmacol Exp Ther 2002 302: 127-137. [Abstract] [Full Text] [PDF]  

Dinesh Srinivasan, Hiromichi Fujino, and John W. Regan

Differential Internalization of the Prostaglandin F₂ Receptor Isoforms: Role of Protein Kinase C and Clathrin
J Pharmacol Exp Ther 2002 302: 219-224. [Abstract] [Full Text] [PDF]  

Walter A. Volberg, Bryan J. Koci, Weiguo Su, Jing Lin, and Jun Zhou

Blockade of Human Cardiac Potassium Channel Human Ether-a-go-go-Related Gene (HERG) by Macrolide Antibiotics
J Pharmacol Exp Ther 2002 302: 320-327. [Abstract] [Full Text] [PDF]  

Raymond G. Booth, Nader H. Moniri, Remko A. Bakker, Neepa Y. Choksi, William B. Nix, Henk Timmerman, and Rob Leurs

A Novel Phenylaminotetralin Radioligand Reveals a Subpopulation of Histamine H₁ Receptors
J Pharmacol Exp Ther 2002 302: 328-336. [Abstract] [Full Text] [PDF]  

Brian A. Shapiro, Sagarika Ray, EunMi Jung, William T. Allred, and Wendy B. Bollag

Putative Conventional Protein Kinase C Inhibitor Gödecke 6976 [12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] Stimulates Transglutaminase Activity in Primary Mouse Epidermal Keratinocytes
J Pharmacol Exp Ther 2002 302: 352-358. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Maja Cemazar, Marija Auersperg, Janez Scancar, Irena Srebotnik Kirbi, Ana Poganik, and Gregor Sera

Schedule-Dependent Interaction between Vinblastine and Cisplatin in Ehrlich Ascites Tumors in Mice
J Pharmacol Exp Ther 2002 302: 337-343. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Sandra J. Hoffman, Janice Vasko-Moser, William H. Miller, Michael W. Lark, Maxine Gowen, and George Stroup

Rapid Inhibition of Thyroxine-Induced Bone Resorption in the Rat by an Orally Active Vitronectin Receptor Antagonist
J Pharmacol Exp Ther 2002 302: 205-211. [Abstract] [Full Text] [PDF]  

M. Sato, Y. L. Ma, J. M. Hock, M. S. Westmore, J. Vahle, A. Villanueva, and C. H. Turner

Skeletal Efficacy with Parathyroid Hormone in Rats Was Not Entirely Beneficial with Long-Term Treatment
J Pharmacol Exp Ther 2002 302: 304-313. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Brian S. Cummings and Rick G. Schnellmann

Cisplatin-Induced Renal Cell Apoptosis: Caspase 3-Dependent and -Independent Pathways
J Pharmacol Exp Ther 2002 302: 8-17. [Abstract] [Full Text] [PDF]  

Atsushi Masamune, Kazuhiro Kikuta, Masahiro Satoh, Akihiko Satoh, and Tooru Shimosegawa

Alcohol Activates Activator Protein-1 and Mitogen-Activated Protein Kinases in Rat Pancreatic Stellate Cells
J Pharmacol Exp Ther 2002 302: 36-42. [Abstract] [Full Text] [PDF]  

Xiuli Liu, Jay F. Harriman, and Rick G. Schnellmann

Cytoprotective Properties of Novel Nonpeptide Calpain Inhibitors in Renal Cells
J Pharmacol Exp Ther 2002 302: 88-94. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Ryuta Yamazaki, Natsuko Kusunoki, Takeshi Matsuzaki, Shusuke Hashimoto, and Shinichi Kawai

Nonsteroidal Anti-Inflammatory Drugs Induce Apoptosis in Association with Activation of Peroxisome Proliferator-Activated Receptor in Rheumatoid Synovial Cells
J Pharmacol Exp Ther 2002 302: 18-25. [Abstract] [Full Text] [PDF]  

Jong S. Kang, Young J. Jeon, Hwan M. Kim, Seung H. Han, and Kyu-Hwan Yang

Inhibition of Inducible Nitric-Oxide Synthase Expression by Silymarin in Lipopolysaccharide-Stimulated Macrophages
J Pharmacol Exp Ther 2002 302: 138-144. [Abstract] [Full Text] [PDF]  

Linda A. Egger, Usha Kidambi, Jin Cao, Gail Van Riper, Ermengilda McCauley, Richard A. Mumford, Suzanne Amo, Russell Lingham, Thomas Lanza, Linus S. Lin, Stephen E. de Laszlo, David N. Young, Ihor E. Kopka, Sharon Tong, Bill Pikounis, Evelyn Benson, Sarah Warwood, Robert F. Bargatze, William K. Hagmann, John A. Schmidt, and Patricia A. Detmers

₄₇/₄₁ Dual Integrin Antagonists Block ₄₇-Dependent Adhesion under Shear Flow
J Pharmacol Exp Ther 2002 302: 153-162. [Abstract] [Full Text] [PDF]  

Kent W. Christopherson, II, James J. Campbell, Jeffrey B. Travers, and Robert A. Hromas

Low-Molecular-Weight Heparins Inhibit CCL21-Induced T Cell Adhesion and Migration
J Pharmacol Exp Ther 2002 302: 290-295. [Abstract] [Full Text] [PDF]  

G. Beck, G. Bottomley, D. Bradshaw, M. Brewster, M. Broadhurst, R. Devos, C. Hill, W. Johnson, H.-J. Kim, S. Kirtland, J. Kneer, N. Lad, R. Mackenzie, R. Martin, J. Nixon, G. Price, A. Rodwell, F. Rose, J.-P. Tang, D. S. Walter, K. Wilson, and E. Worth

(E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-2'-(methanesulfonyl)-4-methylvalerohydrazide (Ro 32-7315), a Selective and Orally Active Inhibitor of Tumor Necrosis Factor- Convertase
J Pharmacol Exp Ther 2002 302: 390-396. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Carolyn Paul and Christopher Bolton

Modulation of Blood-Brain Barrier Dysfunction and Neurological Deficits during Acute Experimental Allergic Encephalomyelitis by the N-Methyl-D-aspartate Receptor Antagonist Memantine
J Pharmacol Exp Ther 2002 302: 50-57. [Abstract] [Full Text] [PDF]  

Aron H. Lichtman, E. Gregory Hawkins, Graeme Griffin, and Benjamin F. Cravatt

Pharmacological Activity of Fatty Acid Amides Is Regulated, but Not Mediated, by Fatty Acid Amide Hydrolase in Vivo
J Pharmacol Exp Ther 2002 302: 73-79. [Abstract] [Full Text] [PDF]  

J. Shane Hardin, William D. Wessinger, Galen R. Wenger, Joel W. Proksch, Elizabeth M. Laurenzana, and S. Michael Owens

A Single Dose of Monoclonal Anti-Phencyclidine IgG Offers Long-Term Reductions in Phencyclidine Behavioral Effects in Rats
J Pharmacol Exp Ther 2002 302: 119-126. [Abstract] [Full Text] [PDF]  

Mary Ann Pelleymounter, Margaret Joppa, Nicholas Ling, and Alan C. Foster

Pharmacological Evidence Supporting a Role for Central Corticotropin-Releasing Factor₂ Receptors in Behavioral, but not Endocrine, Response to Environmental Stress
J Pharmacol Exp Ther 2002 302: 145-152. [Abstract] [Full Text] [PDF]  

Rosa Planells-Cases, Carmina Montoliu, Marc Humet, Asia M. Fernández, Carolina García-Martínez, Elvira Valera, Jaime M. Merino, Enrique Pérez-Payá, Angel Messeguer, Vicente Felipo, and Antonio Ferrer-Montiel

A Novel N-Methyl-D-aspartate Receptor Open Channel Blocker with in Vivo Neuroprotectant Activity
J Pharmacol Exp Ther 2002 302: 163-173. [Abstract] [Full Text] [PDF]  

Heberto Suarez-Roca and Luigi X. Cubeddu

The Selective Serotonin Reuptake Inhibitor Citalopram Induces the Storage of Serotonin in Catecholaminergic Terminals
J Pharmacol Exp Ther 2002 302: 174-179. [Abstract] [Full Text] [PDF]  

Maneesh Gupta, Rachel Greven, Erwin E. W. Jansen, Cornelis Jakobs, Boris M. Hogema, Wolfgang Froestl, O. Carter Snead, Hilke Bartels, Markus Grompe, and K. Michael Gibson

Therapeutic Intervention in Mice Deficient for Succinate Semialdehyde Dehydrogenase (-Hydroxybutyric Aciduria)
J Pharmacol Exp Ther 2002 302: 180-187. [Abstract] [Full Text] [PDF]  

Guo-Min Zhao, Dunli Wu, Yi Soong, Megumi Shimoyama, Irena Berezowska, Peter W. Schiller, and Hazel H. Szeto

Profound Spinal Tolerance after Repeated Exposure to a Highly Selective µ-Opioid Peptide Agonist: Role of -Opioid Receptors
J Pharmacol Exp Ther 2002 302: 188-196. [Abstract] [Full Text] [PDF]  

Adrian J. Mogg, Paul Whiteaker, J. Michael McIntosh, Michael Marks, Allan C. Collins, and Susan Wonnacott

Methyllycaconitine Is a Potent Antagonist of -Conotoxin-MII-Sensitive Presynaptic Nicotinic Acetylcholine Receptors in Rat Striatum
J Pharmacol Exp Ther 2002 302: 197-204. [Abstract] [Full Text] [PDF]  

Ken-ichi Hosoya, Masatoshi Tomi, Sumio Ohtsuki, Hitomi Takanaga, Shigeki Saeki, Yoshikatsu Kanai, Hitoshi Endou, Mikihiko Naito, Takashi Tsuruo, and Tetsuya Terasaki

Enhancement of L-Cystine Transport Activity and Its Relation to xCT Gene Induction at the Blood-Brain Barrier by Diethyl Maleate Treatment
J Pharmacol Exp Ther 2002 302: 225-231. [Abstract] [Full Text] [PDF]  

Pascal Bonaventure, Diane Nepomuceno, Annette Kwok, Wenying Chai, Xavier Langlois, Rene Hen, Kimberly Stark, Nicholas Carruthers, and Timothy W. Lovenberg

Reconsideration of 5-Hydroxytryptamine (5-HT)₇ Receptor Distribution Using [³H]5-Carboxamidotryptamine and [³H]8-Hydroxy-2-(di-n-propylamino)tetraline: Analysis in Brain of 5-HT_1A Knockout and 5-HT_1A/1B Double-Knockout Mice
J Pharmacol Exp Ther 2002 302: 240-248. [Abstract] [Full Text] [PDF]  

Neesha U. Suvarna and James M. O'Donnell

Hydrolysis of N-Methyl-D-aspartate Receptor-Stimulated cAMP and cGMP by PDE4 and PDE2 Phosphodiesterases in Primary Neuronal Cultures of Rat Cerebral Cortex and Hippocampus
J Pharmacol Exp Ther 2002 302: 249-256. [Abstract] [Full Text] [PDF]  

Julie Pannequin, Catherine Oiry, Caroline Morel, Jérôme Kucharczak, Isabelle Camby, Robert Kiss, Didier Gagne, Jean-Claude Galleyrand, and Jean Martinez

C-Terminal Heptapeptide of Gastrin Inhibits Astrocytomas Motility by Interacting with a New Gastrin Binding Site
J Pharmacol Exp Ther 2002 302: 274-282. [Abstract] [Full Text] [PDF]  

Frank Mauler, Joachim Mittendorf, Ervin Horváth, and Jean de Vry

Characterization of the Diarylether Sulfonylester ()-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a Potent Cannabinoid Receptor Agonist with Neuroprotective Properties
J Pharmacol Exp Ther 2002 302: 359-368. [Abstract] [Full Text] [PDF]  

Jean M. Bidlack, Dana J. Cohen, Jay P. McLaughlin, Rongliang Lou, Yingchun Ye, and Mark P. Wentland

8-Carboxamidocyclazocine: A Long-Acting, Novel Benzomorphan
J Pharmacol Exp Ther 2002 302: 374-380. [Abstract] [Full Text] [PDF]  

Kevin D. Burris, Thaddeus F. Molski, Cen Xu, Elaine Ryan, Katsura Tottori, Tetsuro Kikuchi, Frank D. Yocca, and Perry B. Molinoff

Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors
J Pharmacol Exp Ther 2002 302: 381-389. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Masashi Kitazawa, Jarrad R. Wagner, Michael L. Kirby, Vellareddy Anantharam, and Anumantha G. Kanthasamy

Oxidative Stress and Mitochondrial-Mediated Apoptosis in Dopaminergic Cells Exposed to Methylcyclopentadienyl Manganese Tricarbonyl
J Pharmacol Exp Ther 2002 302: 26-35. [Abstract] [Full Text] [PDF]  

Yasushi Ito, Shinji Sato, Masami Son, Masashi Kondo, Hiroaki Kume, Kenzo Takagi, and Kenichi Yamaki

Bisphenol A Inhibits Cl Secretion by Inhibition of Basolateral K⁺ Conductance in Human Airway Epithelial Cells
J Pharmacol Exp Ther 2002 302: 80-87. [Abstract] [Full Text] [PDF]  

Stephen W. Luckey, Melinda Taylor, Brante P. Sampey, Robert I. Scheinman, and Dennis R. Petersen

4-Hydroxynonenal Decreases Interleukin-6 Expression and Protein Production in Primary Rat Kupffer Cells by Inhibiting Nuclear Factor-B Activation
J Pharmacol Exp Ther 2002 302: 296-303. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Functional Selectivity of Dopamine Receptor Agonists. I. Selective Activation of Postsynaptic Dopamine D₂ Receptors Linked to Adenylate Cyclase"
J Pharmacol Exp Ther 2002 302: 406. [Full Text] [PDF]  

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