PERSPECTIVES IN PHARMACOLOGY:

Nick E. Goeders

Stress and Cocaine Addiction
J Pharmacol Exp Ther 2002 301: 785-789. [Abstract] [Full Text] [PDF]  

Billy R. Martin

Identification of the Endogenous Cannabinoid System through Integrative Pharmacological Approaches
J Pharmacol Exp Ther 2002 301: 790-796. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Atsushi Enomoto, Michio Takeda, Minoru Shimoda, Shinichi Narikawa, Yukari Kobayashi, Yasuna Kobayashi, Toshinori Yamamoto, Takashi Sekine, Seok Ho Cha, Toshimitsu Niwa, and Hitoshi Endou

Interaction of Human Organic Anion Transporters 2 and 4 with Organic Anion Transport Inhibitors
J Pharmacol Exp Ther 2002 301: 797-802. [Abstract] [Full Text] [PDF]  

Cathaleen Shu, Hong Shen, Nathan S. Teuscher, Philip J. Lorenzi, Richard F. Keep, and David E. Smith

Role of PEPT2 in Peptide/Mimetic Trafficking at the Blood-Cerebrospinal Fluid Barrier: Studies in Rat Choroid Plexus Epithelial Cells in Primary Culture
J Pharmacol Exp Ther 2002 301: 820-829. [Abstract] [Full Text] [PDF]  

Nagendra S. Ningaraj, Mamatha Rao, Kazuhiro Hashizume, Kamlesh Asotra, and Keith L. Black

Regulation of Blood-Brain Tumor Barrier Permeability by Calcium-Activated Potassium Channels
J Pharmacol Exp Ther 2002 301: 838-851. [Abstract] [Full Text] [PDF]  

Chitra Sridar, Ute M. Kent, Lisa M. Notley, Elizabeth M. J. Gillam, and Paul F. Hollenberg

Effect of Tamoxifen on the Enzymatic Activity of Human Cytochrome CYP2B6
J Pharmacol Exp Ther 2002 301: 945-952. [Abstract] [Full Text] [PDF]  

Elizabeth Fox, Peter M. Bungay, John Bacher, Cynthia L. McCully, Robert L. Dedrick, and Frank M. Balis

Zidovudine Concentration in Brain Extracellular Fluid Measured by Microdialysis: Steady-State and Transient Results in Rhesus Monkey
J Pharmacol Exp Ther 2002 301: 1003-1011. [Abstract] [Full Text] [PDF]  

Camille P. Granvil, Kristopher W. Krausz, Harry V. Gelboin, Jeffrey R. Idle, and Frank J. Gonzalez

4-Hydroxylation of Debrisoquine by Human CYP1A1 and Its Inhibition by Quinidine and Quinine
J Pharmacol Exp Ther 2002 301: 1025-1032. [Abstract] [Full Text] [PDF]  

Thomayant Prueksaritanont, Jamie J. Zhao, Bennett Ma, Brad A. Roadcap, Cuyue Tang, Yue Qiu, Lida Liu, Jiunn H. Lin, Paul G. Pearson, and Thomas A. Baillie

Mechanistic Studies on Metabolic Interactions between Gemfibrozil and Statins
J Pharmacol Exp Ther 2002 301: 1042-1051. [Abstract] [Full Text] [PDF]  

Daniel Y. Hung, Ping Chang, Kee Cheung, Brett McWhinney, Paul P. Masci, Michael Weiss, and Michael S. Roberts

Cationic Drug Pharmacokinetics in Diseased Livers Determined by Fibrosis Index, Hepatic Protein Content, Microsomal Activity, and Nature of Drug
J Pharmacol Exp Ther 2002 301: 1079-1087. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

S. A. Varvel and A. H. Lichtman

Evaluation of CB₁ Receptor Knockout Mice in the Morris Water Maze
J Pharmacol Exp Ther 2002 301: 915-924. [Abstract] [Full Text] [PDF]  

Kelly P. Cosgrove and Marilyn E. Carroll

Effects of Bremazocine on Self-Administration of Smoked Cocaine Base and Orally Delivered Ethanol, Phencyclidine, Saccharin, and Food in Rhesus Monkeys: A Behavioral Economic Analysis
J Pharmacol Exp Ther 2002 301: 993-1002. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Susan Ji, Toshimasa Tosaka, Bernard H. Whitfield, Alexander N. Katchman, Abdurrahman Kandil, Bjoern C. Knollmann, and Steven N. Ebert

Differential Rate Responses to Nicotine in Rat Heart: Evidence for Two Classes of Nicotinic Receptors
J Pharmacol Exp Ther 2002 301: 893-899. [Abstract] [Full Text] [PDF]  

Hong Yan Zhang, Bradley C. McPherson, Huiping Liu, Timir Baman, Steven S. McPherson, Peter Rock, and Zhenhai Yao

Role of Nitric-Oxide Synthase, Free Radicals, and Protein Kinase C in Opioid-Induced Cardioprotection
J Pharmacol Exp Ther 2002 301: 1012-1019. [Abstract] [Full Text] [PDF]  

Luke J. Janssen and Tracy Tazzeo

Involvement of TP and EP₃ Receptors in Vasoconstrictor Responses to Isoprostanes in Pulmonary Vasculature
J Pharmacol Exp Ther 2002 301: 1060-1066. [Abstract] [Full Text] [PDF]  

James K. Hennan, Ting-Ting Hong, Ardamanpal K. Shergill, Edward M. Driscoll, Alan D. Cardin, and Benedict R. Lucchesi

Intimatan Prevents Arterial and Venous Thrombosis in a Canine Model of Deep Vessel Wall Injury
J Pharmacol Exp Ther 2002 301: 1151-1156. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Yutaro Obara, Takashi Aoki, Masayoshi Kusano, and Yasushi Ohizumi

-Eudesmol Induces Neurite Outgrowth in Rat Pheochromocytoma Cells Accompanied by an Activation of Mitogen-Activated Protein Kinase
J Pharmacol Exp Ther 2002 301: 803-811. [Abstract] [Full Text] [PDF]  

A. Banan, J. Z. Fields, A. Farhadi, D. A. Talmage, L. Zhang, and A. Keshavarzian

The 1 Isoform of Protein Kinase C Mediates the Protective Effects of Epidermal Growth Factor on the Dynamic Assembly of F-Actin Cytoskeleton and Normalization of Calcium Homeostasis in Human Colonic Cells
J Pharmacol Exp Ther 2002 301: 852-866. [Abstract] [Full Text] [PDF]  

A. R. West, H. Moore, and A. A. Grace

Direct Examination of Local Regulation of Membrane Activity in Striatal and Prefrontal Cortical Neurons in Vivo Using Simultaneous Intracellular Recording and Microdialysis
J Pharmacol Exp Ther 2002 301: 867-877. [Abstract] [Full Text] [PDF]  

Ruth A. Ross, Susan J. Craib, Lesley A. Stevenson, Roger G. Pertwee, Andrea Henderson, John Toole, and Heather C. Ellington

Pharmacological Characterization of the Anandamide Cyclooxygenase Metabolite: Prostaglandin E₂ Ethanolamide
J Pharmacol Exp Ther 2002 301: 900-907. [Abstract] [Full Text] [PDF]  

Youn J. Lee, Annayya R. Aroor, and Shivendra D. Shukla

Temporal Activation of p42/44 Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase by Acetaldehyde in Rat Hepatocytes and Its Loss after Chronic Ethanol Exposure
J Pharmacol Exp Ther 2002 301: 908-914. [Abstract] [Full Text] [PDF]  

Shawn D. Spencer, Oluseyi Abdul, Robert J. Schulingkamp, and Robert B. Raffa

Toward the Design of Ribonuclease (RNase) Inhibitors: Ion Effects on the Thermodynamics of Binding of 2'-CMP to RNase A
J Pharmacol Exp Ther 2002 301: 925-929. [Abstract] [Full Text] [PDF]  

Eugenia Bloch-Shilderman, Saleh Abu-Raya, Victoria Trembovler, Hassia Boschwitz, Arie Gruzman, Michal Linial, and Philip Lazarovici

Pardaxin Stimulation of Phospholipases A₂ and Their Involvement in Exocytosis in PC-12 Cells
J Pharmacol Exp Ther 2002 301: 953-962. [Abstract] [Full Text] [PDF]  

Jan Jakubík, Stanislav Tuek, and Esam E. El-Fakahany

Allosteric Modulation by Persistent Binding of Xanomeline of the Interaction of Competitive Ligands with the M₁ Muscarinic Acetylcholine Receptor
J Pharmacol Exp Ther 2002 301: 1033-1041. [Abstract] [Full Text] [PDF]  

E. E. Daniel, T. J. Bowes, and J. Jury

Roles of Guanylate Cyclase in Responses to Myogenic and Neural Nitric Oxide in Canine Lower Esophageal Sphincter
J Pharmacol Exp Ther 2002 301: 1111-1118. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Hidekazu Toyobuku, Yoshimichi Sai, Ikumi Tamai, and Akira Tsuji

Enhanced Delivery of Drugs to the Liver by Adenovirus-Mediated Heterologous Expression of the Human Oligopeptide Transporter PEPT1
J Pharmacol Exp Ther 2002 301: 812-819. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

T. J. McCarthy, W. A. Banks, C. L. Farrell, S. Adamu, C. P. Derdeyn, A. Z. Snyder, R. Laforest, D. C. Litzinger, D. Martin, C. P. LeBel, and M. J. Welch

Positron Emission Tomography Shows that Intrathecal Leptin Reaches the Hypothalamus in Baboons
J Pharmacol Exp Ther 2002 301: 878-883. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Eleni Papakonstantinou, Michael Roth, Michael Tamm, Oliver Eickelberg, Andre P. Perruchoud, and George Karakiulakis

Hypoxia Differentially Enhances the Effects of Transforming Growth Factor- Isoforms on the Synthesis and Secretion of Glycosaminoglycans by Human Lung Fibroblasts
J Pharmacol Exp Ther 2002 301: 830-837. [Abstract] [Full Text] [PDF]  

Brian J. Dewar, Blair U. Bradford, and Ronald G. Thurman

Nicotine Increases Hepatic Oxygen Uptake in the Isolated Perfused Rat Liver by Inhibiting Glycolysis
J Pharmacol Exp Ther 2002 301: 930-937. [Abstract] [Full Text] [PDF]  

Brigitta M. Peskar, Karlheinz Ehrlich, and Bernhard A. Peskar

Role of ATP-Sensitive Potassium Channels in Prostaglandin-Mediated Gastroprotection in the Rat
J Pharmacol Exp Ther 2002 301: 969-974. [Abstract] [Full Text] [PDF]  

Timothy D. Westfall, Gerald P. McCafferty, Mark Pullen, Susan Gruver, Anthony C. Sulpizio, V. Nambi Aiyar, Jyoti Disa, Lisa C. Contino, Ishrat J. Mannan, and J. Paul Hieble

Characterization of Neuromedin U Effects in Canine Smooth Muscle
J Pharmacol Exp Ther 2002 301: 987-992. [Abstract] [Full Text] [PDF]  

R. J. Kok, R. F. G. Haverdings, F. Grijpstra, J. Koiter, F. Moolenaar, D. de Zeeuw, and D. K. F. Meijer

Targeting of Captopril to the Kidney Reduces Renal Angiotensin-Converting Enzyme Activity without Affecting Systemic Blood Pressure
J Pharmacol Exp Ther 2002 301: 1139-1143. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Sergio Pablo Sardi, Verónica Rey-Ares, Virginia Andrea Pujol-Lereis, Santiago Alejo Serrano, and Rodolfo Pedro Rothlin

Further Pharmacological Evidence of Nuclear Factor-B Pathway Involvement in Bradykinin B₁ Receptor-Sensitized Responses in Human Umbilical Vein
J Pharmacol Exp Ther 2002 301: 975-980. [Abstract] [Full Text] [PDF]  

Seung Joon Baek, Leigh C. Wilson, Chang-Ho Lee, and Thomas E. Eling

Dual Function of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Inhibition of Cyclooxygenase and Induction of NSAID-Activated Gene
J Pharmacol Exp Ther 2002 301: 1126-1131. [Abstract] [Full Text] [PDF]  

Kenji Okajima, Naoaki Harada, and Mitsuhiro Uchiba

Ranitidine Reduces Ischemia/Reperfusion-Induced Liver Injury in Rats by Inhibiting Neutrophil Activation
J Pharmacol Exp Ther 2002 301: 1157-1165. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Adam W. Hendricson, C. L. Alek Miao, Melanie J. Lippmann, and Richard A. Morrisett

Ifenprodil and Ethanol Enhance NMDA Receptor-Dependent Long-Term Depression
J Pharmacol Exp Ther 2002 301: 938-944. [Abstract] [Full Text] [PDF]  

S. M. Rawls, Jose Cabassa, Ellen B. Geller, and Martin W. Adler

CB₁ Receptors in the Preoptic Anterior Hypothalamus Regulate WIN 55212-2 [(4,5-Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one]-Induced Hypothermia
J Pharmacol Exp Ther 2002 301: 963-968. [Abstract] [Full Text] [PDF]  

Herbert M. Himmel, Thomas Kiss, Sebestyén J. Borvendeg, Clemens Gillen, and Peter Illes

The Arginine-Rich Hexapeptide R₄W₂ Is a Stereoselective Antagonist at the Vanilloid Receptor 1: A Ca²⁺ Imaging Study in Adult Rat Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther 2002 301: 981-986. [Abstract] [Full Text] [PDF]  

Amy C. Porter, John-Michael Sauer, Michael D. Knierman, Gerald W. Becker, Michael J. Berna, Jingqi Bao, George G. Nomikos, Petra Carter, Frank P. Bymaster, Andrea Baker Leese, and Christian C. Felder

Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 Receptor
J Pharmacol Exp Ther 2002 301: 1020-1024. [Abstract] [Full Text] [PDF]  

Francisco Sala, José Mulet, Seok Choi, Se-Yeon Jung, Seung-Yeol Nah, Hyewhon Rhim, Luis Miguel Valor, Manuel Criado, and Salvador Sala

Effects of Ginsenoside Rg₂ on Human Neuronal Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 2002 301: 1052-1059. [Abstract] [Full Text] [PDF]  

Badia Ferzaz, Emmanuel Brault, Genevieve Bourliaud, Jean-Pierre Robert, Gilles Poughon, Yves Claustre, Franck Marguet, Philippe Liere, Michael Schumacher, Jean-Pierre Nowicki, Jacqueline Fournier, Benoit Marabout, Mireille Sevrin, Pascal George, Philippe Soubrie, Jesus Benavides, and Bernard Scatton

SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a Peripheral Benzodiazepine Receptor Ligand, Promotes Neuronal Survival and Repair
J Pharmacol Exp Ther 2002 301: 1067-1078. [Abstract] [Full Text] [PDF]  

Lincoln H. Wilkins, Jr., Aaron Haubner, Joshua T. Ayers, Peter A. Crooks, and Linda P. Dwoskin

N-n-Alkylnicotinium Analogs, A Novel Class of Nicotinic Receptor Antagonist: Inhibition of S()-Nicotine-Evoked [³H]Dopamine Overflow from Superfused Rat Striatal Slices
J Pharmacol Exp Ther 2002 301: 1088-1096. [Abstract] [Full Text] [PDF]  

Eugen Davids, Kehong Zhang, Nora S. Kula, Frank I. Tarazi, and Ross J. Baldessarini

Effects of Norepinephrine and Serotonin Transporter Inhibitors on Hyperactivity Induced by Neonatal 6-Hydroxydopamine Lesioning in Rats
J Pharmacol Exp Ther 2002 301: 1097-1102. [Abstract] [Full Text] [PDF]  

Stacy L. Sell and Charles P. France

Cocaine and Amphetamine Attenuate the Discriminative Stimulus Effects of Naltrexone in Opioid-Dependent Rhesus Monkeys
J Pharmacol Exp Ther 2002 301: 1103-1110. [Abstract] [Full Text] [PDF]  

Xu-Feng Zhang, Donald C. Cooper, and Francis J. White

Repeated Cocaine Treatment Decreases Whole-Cell Calcium Current in Rat Nucleus Accumbens Neurons
J Pharmacol Exp Ther 2002 301: 1119-1125. [Abstract] [Full Text] [PDF]  

Eugenii A. Rabiner, Martin R. Wilkins, Federico Turkheimer, Roger N. Gunn, Joanna Udo de Haes, Michiel de Vries, and Paul M. Grasby

5-Hydroxytryptamine_1A Receptor Occupancy by Novel Full Antagonist 2-[4-[4-(7-Chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: A [¹¹C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide Trihydrochloride (WAY-100635) Positron Emission Tomography Study in Humans
J Pharmacol Exp Ther 2002 301: 1144-1150. [Abstract] [Full Text] [PDF]  

David M. Mottola, Jason D. Kilts, Mechelle M. Lewis, Hilary S. Connery, Q. David Walker, Sara R. Jones, Raymond G. Booth, Deborah K. Hyslop, Monford Piercey, R. Mark Wightman, Cindy P. Lawler, David E. Nichols, and Richard B. Mailman

Functional Selectivity of Dopamine Receptor Agonists. I. Selective Activation of Postsynaptic Dopamine D₂ Receptors Linked to Adenylate Cyclase
J Pharmacol Exp Ther 2002 301: 1166-1178. [Abstract] [Full Text] [PDF]  

Jason D. Kilts, Hilary S. Connery, Elaine G. Arrington, Mechelle M. Lewis, Cindy P. Lawler, Gerry S. Oxford, Karen L. O'Malley, Richard D. Todd, Bonita L. Blake, David E. Nichols, and Richard B. Mailman

Functional Selectivity of Dopamine Receptor Agonists. II. Actions of Dihydrexidine in D_2L Receptor-Transfected MN9D Cells and Pituitary Lactotrophs
J Pharmacol Exp Ther 2002 301: 1179-1189. [Abstract] [Full Text] [PDF]  

Michael H. Baumann, Mario A. Ayestas, Lawrence G. Sharpe, David B. Lewis, Kenner C. Rice, and Richard B. Rothman

Persistent Antagonism of Methamphetamine-Induced Dopamine Release in Rats Pretreated with GBR12909 Decanoate
J Pharmacol Exp Ther 2002 301: 1190-1197. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Martijn Rooseboom, Gerben Schaaf, Jan N. M. Commandeur, Nico P. E. Vermeulen, and Johanna Fink-Gremmels

-Lyase-Dependent Attenuation of Cisplatin-Mediated Toxicity by Selenocysteine Se-Conjugates in Renal Tubular Cell Lines
J Pharmacol Exp Ther 2002 301: 884-892. [Abstract] [Full Text] [PDF]  

Elizabeth C. Brown, Daniel S. Perrien, Terry W. Fletcher, David J. Irby, James Aronson, Guan G. Gao, William J. Hogue, Robert A. Skinner, Larry J. Suva, Martin J. J. Ronis, Reza Hakkak, Thomas M. Badger, and Charles K. Lumpkin, Jr.

Skeletal Toxicity Associated with Chronic Ethanol Exposure in a Rat Model Using Total Enteral Nutrition
J Pharmacol Exp Ther 2002 301: 1132-1138. [Abstract] [Full Text] [PDF]  

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