PERSPECTIVES IN PHARMACOLOGY:

Kenneth L. Audus, Michael J. Soares, and Joan S. Hunt

Characteristics of the Fetal/Maternal Interface with Potential Usefulness in the Development of Future Immunological and Pharmacological Strategies
J Pharmacol Exp Ther 2002 301: 402-409. [Abstract] [Full Text] [PDF]  

Robert P. Carson and David Robertson

Genetic Manipulation of Noradrenergic Neurons
J Pharmacol Exp Ther 2002 301: 410-417. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Yasuomi Yamasaki, Kazuya Sumimoto, Makiya Nishikawa, Fumiyoshi Yamashita, Kiyoshi Yamaoka, Mitsuru Hashida, and Yoshinobu Takakura

Pharmacokinetic Analysis of in Vivo Disposition of Succinylated Proteins Targeted to Liver Nonparenchymal Cells via Scavenger Receptors: Importance of Molecular Size and Negative Charge Density for in Vivo Recognition by Receptors
J Pharmacol Exp Ther 2002 301: 467-477. [Abstract] [Full Text] [PDF]  

James T. Dalton, Charles R. Yates, Donghua Yin, Arthur Straughn, Stuart L. Marcus, Allyn L. Golub, and Marvin C. Meyer

Clinical Pharmacokinetics of 5-Aminolevulinic Acid in Healthy Volunteers and Patients at High Risk for Recurrent Bladder Cancer
J Pharmacol Exp Ther 2002 301: 507-512. [Abstract] [Full Text] [PDF]  

Ning Li, Dylan P. Hartley, Nathan J. Cherrington, and Curtis D. Klaassen

Tissue Expression, Ontogeny, and Inducibility of Rat Organic Anion Transporting Polypeptide 4
J Pharmacol Exp Ther 2002 301: 551-560. [Abstract] [Full Text] [PDF]  

Sylvie A. Terlouw, Claudia Graeff, Pascal H. E. Smeets, Gert Fricker, Frans G. M. Russel, Rosalinde Masereeuw, and David S. Miller

Short- and Long-Term Influences of Heavy Metals on Anionic Drug Efflux from Renal Proximal Tubule
J Pharmacol Exp Ther 2002 301: 578-585. [Abstract] [Full Text] [PDF]  

Lilian Y. Li, Gordon L. Amidon, Jae Seung Kim, Tycho Heimbach, Filippos Kesisoglou, John T. Topliss, and David Fleisher

Intestinal Metabolism Promotes Regional Differences in Apical Uptake of Indinavir: Coupled Effect of P-Glycoprotein and Cytochrome P450 3A on Indinavir Membrane Permeability in Rat
J Pharmacol Exp Ther 2002 301: 586-593. [Abstract] [Full Text] [PDF]  

Delia Dempsey, Peyton Jacob, III, and Neal L. Benowitz

Accelerated Metabolism of Nicotine and Cotinine in Pregnant Smokers
J Pharmacol Exp Ther 2002 301: 594-598. [Abstract] [Full Text] [PDF]  

J. J. Rob Hermans, Helma van Essen, Harry A. J. Struijker-Boudier, Randolph M. Johnson, Felix Theeuwes, and Jos F. M. Smits

Pharmacokinetic Advantage of Intrapericardially Applied Substances in the Rat
J Pharmacol Exp Ther 2002 301: 672-678. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

G. Winger, S. R. Hursh, K. L. Casey, and J. H. Woods

Relative Reinforcing Strength of Three N-Methyl-D-Aspartate Antagonists with Different Onsets of Action
J Pharmacol Exp Ther 2002 301: 690-697. [Abstract] [Full Text] [PDF]  

M. C. Ko, J. Terner, S. Hursh, J. H. Woods, and G. Winger

Relative Reinforcing Effects of Three Opioids with Different Durations of Action
J Pharmacol Exp Ther 2002 301: 698-704. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Naohiko Kobayashi, Shigefumi Nakano, Shin-ichiro Mita, Tsutomu Kobayashi, Takeaki Honda, Yusuke Tsubokou, and Hiroaki Matsuoka

Involvement of Rho-Kinase Pathway for Angiotensin II-Induced Plasminogen Activator Inhibitor-1 Gene Expression and Cardiovascular Remodeling in Hypertensive Rats
J Pharmacol Exp Ther 2002 301: 459-466. [Abstract] [Full Text] [PDF]  

Jian-Bing Shen and Achilles J. Pappano

On the Role of Phosphatase in Regulation of Cardiac L-Type Calcium Current by Cyclic GMP
J Pharmacol Exp Ther 2002 301: 501-506. [Abstract] [Full Text] [PDF]  

Feng Gao, Chen-Lin Yao, Erhe Gao, Qi-Zhong Mo, Wen-Li Yan, Richard McLaughlin, Bernard L. Lopez, Theodore A. Christopher, and Xin L. Ma

Enhancement of Glutathione Cardioprotection by Ascorbic Acid in Myocardial Reperfusion Injury
J Pharmacol Exp Ther 2002 301: 543-550. [Abstract] [Full Text] [PDF]  

Cecil R. Pace-Asciak, Denis Reynaud, Peter Demin, Rukshana Aslam, and Andrea Sun

A New Family of Thromboxane Receptor Antagonists with Secondary Thromboxane Synthase Inhibition
J Pharmacol Exp Ther 2002 301: 618-624. [Abstract] [Full Text] [PDF]  

Robert G. Tsushima, James E. Kelly, and J. Andrew Wasserstrom

Subconductance Activity Induced by Quinidine and Quinidinium in Purified Cardiac Sarcoplasmic Reticulum Calcium Release Channels
J Pharmacol Exp Ther 2002 301: 729-737. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Sean Ekins, William J. Crumb, R. Dustan Sarazan, James H. Wikel, and Steven A. Wrighton

Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel
J Pharmacol Exp Ther 2002 301: 427-434. [Abstract] [Full Text] [PDF]  

Albert J. Uveges, Dianne Kowal, Yingxin Zhang, Taylor B. Spangler, John Dunlop, Simon Semus, and Philip G. Jones

The Role of Transmembrane Helix 5 in Agonist Binding to the Human H3 Receptor
J Pharmacol Exp Ther 2002 301: 451-458. [Abstract] [Full Text] [PDF]  

Juanita Dortch-Carnes and David E. Potter

Inhibition of cAMP Accumulation by -Receptor Activation in Isolated Iris-Ciliary Bodies: Role of Phosphodiesterase and Protein Kinase C
J Pharmacol Exp Ther 2002 301: 599-604. [Abstract] [Full Text] [PDF]  

S. Carnesecchi, K. Langley, F. Exinger, F. Gosse, and F. Raul

Geraniol, a Component of Plant Essential Oils, Sensitizes Human Colonic Cancer Cells to 5-Fluorouracil Treatment
J Pharmacol Exp Ther 2002 301: 625-630. [Abstract] [Full Text] [PDF]  

José D. Machado, Carmen Alonso, Araceli Morales, José F. Gómez, and Ricardo Borges

Nongenomic Regulation of the Kinetics of Exocytosis by Estrogens
J Pharmacol Exp Ther 2002 301: 631-637. [Abstract] [Full Text] [PDF]  

Fang L. Zhang, Lin Luo, Eric Gustafson, Kyle Palmer, Xudong Qiao, Xuedong Fan, Shijun Yang, Thomas M. Laz, Marvin Bayne, and Frederick Monsma, Jr.

P2Y₁₃: Identification and Characterization of a Novel Gi-Coupled ADP Receptor from Human and Mouse
J Pharmacol Exp Ther 2002 301: 705-713. [Abstract] [Full Text] [PDF]  

Katrin Zahn, Niels Eckstein, Christian Tränkle, Wolfgang Sadée, and Klaus Mohr

Allosteric Modulation of Muscarinic Receptor Signaling: Alcuronium-Induced Conversion of Pilocarpine from an Agonist into an Antagonist
J Pharmacol Exp Ther 2002 301: 720-728. [Abstract] [Full Text] [PDF]  

Adip Roy, Navdha Mittal, Huaibo Zhang, and Subhash C. Pandey

Modulation of Cellular Expression of Glucocorticoid Receptor and Glucocorticoid Response Element-DNA Binding in Rat Brain during Alcohol Drinking and Withdrawal
J Pharmacol Exp Ther 2002 301: 774-784. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Zhiliang Wang, Shujie Wang, Yun Dai, and Steven Grant

Bryostatin 1 Increases 1--D-Arabinofuranosylcytosine-Induced Cytochrome c Release and Apoptosis in Human Leukemia Cells Ectopically Expressing Bcl-x_L
J Pharmacol Exp Ther 2002 301: 568-577. [Abstract] [Full Text] [PDF]  

Giuseppina Di Stefano, Marcella Lanza, Corrado Busi, Luigi Barbieri, and Luigi Fiume

Conjugates of Nucleoside Analogs with Lactosaminated Human Albumin to Selectively Increase the Drug Levels in Liver Blood: Requirements for a Regional Chemotherapy
J Pharmacol Exp Ther 2002 301: 638-642. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Robert P. Jankov, Xiaoping Luo, Peter Demin, Rukshana Aslam, Vicky Hannam, A. Keith Tanswell, and Cecil R. Pace-Asciak

Hepoxilin Analogs Inhibit Bleomycin-Induced Pulmonary Fibrosis in the Mouse
J Pharmacol Exp Ther 2002 301: 435-440. [Abstract] [Full Text] [PDF]  

Chun-Su Yuan, Lucy Dey, Jing-Tian Xie, and Han H. Aung

Gastric Effects of Galanin and Its Interaction with Leptin on Brainstem Neuronal Activity
J Pharmacol Exp Ther 2002 301: 488-493. [Abstract] [Full Text] [PDF]  

Vicente Martínez, Lixin Wang, Jean E. Rivier, Wylie Vale, and Yvette Taché

Differential Actions of Peripheral Corticotropin-Releasing Factor (CRF), Urocortin II, and Urocortin III on Gastric Emptying and Colonic Transit in Mice: Role of CRF Receptor Subtypes 1 and 2
J Pharmacol Exp Ther 2002 301: 611-617. [Abstract] [Full Text] [PDF]  

Peter W. Stengel and Marlene L. Cohen

Muscarinic Receptor Knockout Mice: Role of Muscarinic Acetylcholine Receptors M₂, M₃, and M₄ in Carbamylcholine-Induced Gallbladder Contractility
J Pharmacol Exp Ther 2002 301: 643-650. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Bernie Scallon, Ann Cai, Nancy Solowski, Amy Rosenberg, Xiao-Yu Song, David Shealy, and Carrie Wagner

Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists
J Pharmacol Exp Ther 2002 301: 418-426. [Abstract] [Full Text] [PDF]  

Mana Mirjany, Lap Ho, and Giulio Maria Pasinetti

Role of Cyclooxygenase-2 in Neuronal Cell Cycle Activity and Glutamate-Mediated Excitotoxicity
J Pharmacol Exp Ther 2002 301: 494-500. [Abstract] [Full Text] [PDF]  

Hongshan Li, Guy M. L. Meno-Tetang, Kenji Chiba, Noriyuki Arima, Peter Heining, and William J. Jusko

Pharmacokinetics and Cell Trafficking Dynamics of 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol Hydrochloride (FTY720) in Cynomolgus Monkeys after Single Oral and Intravenous Doses
J Pharmacol Exp Ther 2002 301: 519-526. [Abstract] [Full Text] [PDF]  

M. M. Schweri, H. M. Deutsch, A.T. Massey, and S. G. Holtzman

Biochemical and Behavioral Characterization of Novel Methylphenidate Analogs
J Pharmacol Exp Ther 2002 301: 527-535. [Abstract] [Full Text] [PDF]  

Young Jin Kang, Sook Jae Seo, Hye Sook Yun-Choi, Duk Hyung Lee, Young-Myung Kim, and Ki Churl Chang

A Synthetic Isoquinoline Alkaloid, 1-(-Naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), Reduces Inducible Nitric Oxide Synthase Expression and Improves Survival in a Rodent Model of Endotoxic Shock
J Pharmacol Exp Ther 2002 301: 561-567. [Abstract] [Full Text] [PDF]  

Andreas Pahl, Meixia Zhang, Katalin Török, Hildegard Kuss, Ute Friedrich, Zoltan Magyar, Jozsef Szekely, Katalin Horvath, Kay Brune, and Istvan Szelenyi

Anti-Inflammatory Effects of a Cyclosporine Receptor-Binding Compound, D-43787
J Pharmacol Exp Ther 2002 301: 738-746. [Abstract] [Full Text] [PDF]  

E. Kudlacz, C. Whitney, C. Andresen, A. Duplantier, G. Beckius, L. Chupak, A. Klein, K. Kraus, and A. Milici

Pulmonary Eosinophilia in a Murine Model of Allergic Inflammation Is Attenuated by Small Molecule 41 Antagonists
J Pharmacol Exp Ther 2002 301: 747-752. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Miguel Díaz-Hernández, M. Fátima Pereira, Jesús Pintor, Rodrigo A. Cunha, J. A. Ribeiro, and María Teresa Miras-Portugal

Modulation of the Rat Hippocampal Dinucleotide Receptor by Adenosine Receptor Activation
J Pharmacol Exp Ther 2002 301: 441-450. [Abstract] [Full Text] [PDF]  

Justin McInnis, Cheng Wang, Noelle Anastasio, Mikael Hultman, YanPing Ye, Daniela Salvemini, and Kenneth M. Johnson

The Role of Superoxide and Nuclear Factor-B Signaling in N-Methyl-D-aspartate-Induced Necrosis and Apoptosis
J Pharmacol Exp Ther 2002 301: 478-487. [Abstract] [Full Text] [PDF]  

Robert M. Silva, Henya C. Grossman, Maria M. Hadjimarkou, Grace C. Rossi, Gavril W. Pasternak, and Richard J. Bodnar

Dynorphin A_1-17-Induced Feeding: Pharmacological Characterization Using Selective Opioid Antagonists and Antisense Probes in Rats
J Pharmacol Exp Ther 2002 301: 513-518. [Abstract] [Full Text] [PDF]  

Ruth A. Duffy, Geoffrey B. Varty, Cynthia A. Morgan, and Jean E. Lachowicz

Correlation of Neurokinin (NK) 1 Receptor Occupancy in Gerbil Striatum with Behavioral Effects of NK1 Antagonists
J Pharmacol Exp Ther 2002 301: 536-542. [Abstract] [Full Text] [PDF]  

Bi-Wei Song, Harry V. Vinters, Dafang Wu, and William M. Pardridge

Enhanced Neuroprotective Effects of Basic Fibroblast Growth Factor in Regional Brain Ischemia after Conjugation to a Blood-Brain Barrier Delivery Vector
J Pharmacol Exp Ther 2002 301: 605-610. [Abstract] [Full Text] [PDF]  

Sharon R. Grady, Karen L. Murphy, Jian Cao, Michael J. Marks, J. Michael McIntosh, and Allan C. Collins

Characterization of Nicotinic Agonist-Induced [³H]Dopamine Release from Synaptosomes Prepared from Four Mouse Brain Regions
J Pharmacol Exp Ther 2002 301: 651-660. [Abstract] [Full Text] [PDF]  

Nancy A. Martin, Michael B. Ruckle, Stephanie L. VanHoof, and Paul L. Prather

Agonist, Antagonist, and Inverse Agonist Characteristics of TIPP (H-Tyr-Tic-Phe-Phe-OH), a Selective -Opioid Receptor Ligand
J Pharmacol Exp Ther 2002 301: 661-671. [Abstract] [Full Text] [PDF]  

Jenny L. Wiley, Irina D. Beletskaya, Edward W. Ng, Zongmin Dai, Peter J. Crocker, Anu Mahadevan, Raj K. Razdan, and Billy R. Martin

Resorcinol Derivatives: A Novel Template for the Development of Cannabinoid CB₁/CB₂ and CB₂-Selective Agonists
J Pharmacol Exp Ther 2002 301: 679-689. [Abstract] [Full Text] [PDF]  

Marie-Luise Buchholzer, Claudia Dvorak, Shyam S. Chatterjee, and Jochen Klein

Dual Modulation of Striatal Acetylcholine Release by Hyperforin, a Constituent of St. John's Wort
J Pharmacol Exp Ther 2002 301: 714-719. [Abstract] [Full Text] [PDF]  

W. G. Tatton, R. M. E. Chalmers-Redman, W. J. H. Ju, M. Mammen, G. W. Carlile, A. W. Pong, and N. A. Tatton

Propargylamines Induce Antiapoptotic New Protein Synthesis in Serum- and Nerve Growth Factor (NGF)-Withdrawn, NGF-Differentiated PC-12 Cells
J Pharmacol Exp Ther 2002 301: 753-764. [Abstract] [Full Text] [PDF]  

Roger L. Papke

Enhanced Inhibition of a Mutant Neuronal Nicotinic Acetylcholine Receptor by Agonists: Protection of Function by (E)-N-Methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403)
J Pharmacol Exp Ther 2002 301: 765-773. [Abstract] [Full Text] [PDF]  

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