PERSPECTIVES IN PHARMACOLOGY:

David R. Lynch and Rodney P. Guttmann

Excitotoxicity: Perspectives Based on N-Methyl-D-Aspartate Receptor Subtypes
J Pharmacol Exp Ther 2002 300: 717-723. [Abstract] [Full Text] [PDF]  

Darrell R. Abernethy and Nikolai M. Soldatov

Structure-Functional Diversity of Human L-Type Ca²⁺ Channel: Perspectives for New Pharmacological Targets
J Pharmacol Exp Ther 2002 300: 724-728. [Abstract] [Full Text] [PDF]  

Ronald J. Shebuski and Kenneth S. Kilgore

Role of Inflammatory Mediators in Thrombogenesis
J Pharmacol Exp Ther 2002 300: 729-735. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Arnaud Scherpereel, Jonathan J. Rome, Rainer Wiewrodt, Simon C. Watkins, David Winslow Harshaw, Sean Alder, Melpo Christofidou-Solomidou, Elliott Haut, Juan-Carlos Murciano, Marian Nakada, Steven M. Albelda, and Vladimir R. Muzykantov

Platelet-Endothelial Cell Adhesion Molecule-1-Directed Immunotargeting to Cardiopulmonary Vasculature
J Pharmacol Exp Ther 2002 300: 777-786. [Abstract] [Full Text] [PDF]  

Peter J. Van Ess, Mark P. Mattson, and Robert A. Blouin

Enhanced Induction of Cytochrome P450 Enzymes and CAR Binding in TNF (p55^//p75^/) Double Receptor Knockout Mice Following Phenobarbital Treatment
J Pharmacol Exp Ther 2002 300: 824-830. [Abstract] [Full Text] [PDF]  

Anthony J. Lee, Laura H. Mills, Joseph W. Kosh, Allan H. Conney, and Bao Ting Zhu

NADPH-Dependent Metabolism of Estrone by Human Liver Microsomes
J Pharmacol Exp Ther 2002 300: 838-849. [Abstract] [Full Text] [PDF]  

Michio Takeda, Suparat Khamdang, Shinichi Narikawa, Hiroaki Kimura, Yasuna Kobayashi, Toshinori Yamamoto, Seok Ho Cha, Takashi Sekine, and Hitoshi Endou

Human Organic Anion Transporters and Human Organic Cation Transporters Mediate Renal Antiviral Transport
J Pharmacol Exp Ther 2002 300: 918-924. [Abstract] [Full Text] [PDF]  

Wai Ming Li, Lawrence D. Mayer, and Marcel B. Bally

Prevention of Antibody-Mediated Elimination of Ligand-Targeted Liposomes by Using Poly(Ethylene glycol)-Modified Lipids
J Pharmacol Exp Ther 2002 300: 976-983. [Abstract] [Full Text] [PDF]  

Carolyn L. Cummins, Wolfgang Jacobsen, and Leslie Z. Benet

Unmasking the Dynamic Interplay between Intestinal P-Glycoprotein and CYP3A4
J Pharmacol Exp Ther 2002 300: 1036-1045. [Abstract] [Full Text] [PDF]  

Hiroaki Yamaguchi, Ikuko Yano, Hideyuki Saito, and Ken-ichi Inui

Pharmacokinetic Role of P-Glycoprotein in Oral Bioavailability and Intestinal Secretion of Grepafloxacin in Vivo
J Pharmacol Exp Ther 2002 300: 1063-1069. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Paul W. Czoty, Brett C. Ginsburg, and Leonard L. Howell

Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys
J Pharmacol Exp Ther 2002 300: 831-837. [Abstract] [Full Text] [PDF]  

Lance R. McMahon and Charles P. France

Daily Treatment with Diazepam Differentially Modifies Sensitivity to the Effects of -Aminobutyric Acid_A Modulators on Schedule-Controlled Responding in Rhesus Monkeys
J Pharmacol Exp Ther 2002 300: 1017-1025. [Abstract] [Full Text] [PDF]  

S. Stevens Negus and Nancy K. Mello

Effects of µ-Opioid Agonists on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rhesus Monkeys: Role of µ-Agonist Efficacy
J Pharmacol Exp Ther 2002 300: 1111-1121. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Xin J. Zhou, Nosratola D. Vaziri, Xiu Q. Wang, Fred G. Silva, and Zoltan Laszik

Nitric Oxide Synthase Expression in Hypertension Induced by Inhibition of Glutathione Synthase
J Pharmacol Exp Ther 2002 300: 762-767. [Abstract] [Full Text] [PDF]  

Andreas Bundkirchen, Klara Brixius, Birgit Bölck, and Robert H. G. Schwinger

Bucindolol Exerts Agonistic Activity on the Propranolol-Insensitive State of ₁-Adrenoceptors in Human Myocardium
J Pharmacol Exp Ther 2002 300: 794-801. [Abstract] [Full Text] [PDF]  

P. Pacher, L. Liaudet, P. Bai, L. Virag, J. G. Mabley, G. Haskó, and C. Szabó

Activation of Poly(ADP-Ribose) Polymerase Contributes to Development of Doxorubicin-Induced Heart Failure
J Pharmacol Exp Ther 2002 300: 862-867. [Abstract] [Full Text] [PDF]  

Victoria C. Tu, Joseph J. Bahl, and Qin M. Chen

Signals of Oxidant-Induced Cardiomyocyte Hypertrophy: Key Activation of p70 S6 Kinase-1 and Phosphoinositide 3-Kinase
J Pharmacol Exp Ther 2002 300: 1101-1110. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Yuichi Hashimoto, Takako Niikura, Yuko Ito, Yoshiko Kita, Kenzo Terashita, and Ikuo Nishimoto

Neurotoxic Mechanisms by Alzheimer's Disease-Linked N141I Mutant Presenilin 2
J Pharmacol Exp Ther 2002 300: 736-745. [Abstract] [Full Text] [PDF]  

Diane J. Ford, Anthony Essex, Tracy A. Spalding, Ethan S. Burstein, and John Ellis

Homologous Mutations Near the Junction of the Sixth Transmembrane Domain and the Third Extracellular Loop Lead to Constitutive Activity and Enhanced Agonist Affinity at all Muscarinic Receptor Subtypes
J Pharmacol Exp Ther 2002 300: 810-817. [Abstract] [Full Text] [PDF]  

Hailing Lu, Marina Guizzetti, and Lucio G. Costa

Inorganic Lead Activates the Mitogen-Activated Protein Kinase Kinase-Mitogen-Activated Protein Kinase-p90^RSK Signaling Pathway in Human Astrocytoma Cells via a Protein Kinase C-Dependent Mechanism
J Pharmacol Exp Ther 2002 300: 818-823. [Abstract] [Full Text] [PDF]  

Kellie A. Fecteau, Jianxun Mei, and Hwa-Chain R. Wang

Differential Modulation of Signaling Pathways and Apoptosis of ras-Transformed 10T1/2 Cells by the Depsipeptide FR901228
J Pharmacol Exp Ther 2002 300: 890-899. [Abstract] [Full Text] [PDF]  

Sujatha M. Gopalakrishnan, Steven A. Buckner, Ivan Milicic, Duncan R. Groebe, Kristi L. Whiteaker, David J. Burns, Usha Warrior, and Murali Gopalakrishnan

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K⁺ Channels in Guinea Pig Urinary Bladder Smooth Muscle
J Pharmacol Exp Ther 2002 300: 910-917. [Abstract] [Full Text] [PDF]  

Masayuki Fujino, Xiao-Kang Li, Yusuke Kitazawa, Lei Guo, Mikiko Kawasaki, Naoko Funeshima, Takashi Amano, and Seiichi Suzuki

Distinct Pathways of Apoptosis Triggered by FTY720, Etoposide, and Anti-Fas Antibody in Human T-Lymphoma Cell Line (Jurkat Cells)
J Pharmacol Exp Ther 2002 300: 939-945. [Abstract] [Full Text] [PDF]  

TracyAnn Perry, Debomoy K. Lahiri, Demao Chen, Jie Zhou, Karen T. Y. Shaw, Josephine M. Egan, and Nigel H. Greig

A Novel Neurotrophic Property of Glucagon-Like Peptide 1: A Promoter of Nerve Growth Factor-Mediated Differentiation in PC12 Cells
J Pharmacol Exp Ther 2002 300: 958-966. [Abstract] [Full Text] [PDF]  

Silvio A. Marques, Lady C. Dy, Michael D. Southall, Quiaofang Yi, Eva Smietana, Reuben Kapur, Mariangela Marques, Jeffrey B. Travers, and Dan F. Spandau

The Platelet-Activating Factor Receptor Activates the Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Induces Proliferation of Epidermal Cells through an Epidermal Growth Factor-Receptor-Dependent Pathway
J Pharmacol Exp Ther 2002 300: 1026-1035. [Abstract] [Full Text] [PDF]  

C. Marchetti, S. Ulisse, S. Bruscoli, F. P. Russo, G. Migliorati, F. Schiaffella, M. G. Cifone, C. Riccardi, and R. Fringuelli

Induction of Apoptosis by 1,4-Benzothiazine Analogs in Mouse Thymocytes
J Pharmacol Exp Ther 2002 300: 1053-1062. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Colin L. Sweeney, Miechaleen D. Diers, Joel L. Frandsen, Roland Gunther, Catherine M. Verfaillie, and R. Scott McIvor

Methotrexate Exacerbates Tumor Progression in a Murine Model of Chronic Myeloid Leukemia
J Pharmacol Exp Ther 2002 300: 1075-1084. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Elisabetta Galbiati, Paola Lorenza Caruso, Gabriele Amari, Elisabetta Armani, Silvia Ghirardi, Maurizio Delcanale, and Maurizio Civelli

Effects of 3-Phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]- 2H-1-benzopyran-7-ol (CHF 4056), a Novel Nonsteroidal Estrogen Agonist/Antagonist, on Reproductive and Nonreproductive Tissue
J Pharmacol Exp Ther 2002 300: 802-809. [Abstract] [Full Text] [PDF]  

J. G. Mabley, P. Pacher, G. J. Southan, A. L. Salzman, and C. Szabó

Nicotine Reduces the Incidence of Type I Diabetes in Mice
J Pharmacol Exp Ther 2002 300: 876-881. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Maki Hasegawa, Hiroyuki Kusuhara, Daisuke Sugiyama, Kousei Ito, Shirou Ueda, Hitoshi Endou, and Yuichi Sugiyama

Functional Involvement of Rat Organic Anion Transporter 3 (rOat3; Slc22a8) in the Renal Uptake of Organic Anions
J Pharmacol Exp Ther 2002 300: 746-753. [Abstract] [Full Text] [PDF]  

Shiho Okano, Yoshinori Ikeura, and Nobuhiro Inatomi

Effects of Tachykinin NK₁ Receptor Antagonists on the Viscerosensory Response Caused by Colorectal Distention in Rabbits
J Pharmacol Exp Ther 2002 300: 925-931. [Abstract] [Full Text] [PDF]  

Kalina Venkova, D. M. Sutkowski-Markmann, and Beverley Greenwood-Van Meerveld

Peripheral Activity of a New NK₁ Receptor Antagonist TAK-637 in the Gastrointestinal Tract
J Pharmacol Exp Ther 2002 300: 1046-1052. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Akiko Tanaka, Shoko Hase, Tohru Miyazawa, and Koji Takeuchi

Up-Regulation of Cyclooxygenase-2 by Inhibition of Cyclooxygenase-1: A Key to Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage
J Pharmacol Exp Ther 2002 300: 754-761. [Abstract] [Full Text] [PDF]  

Mirella Profita, Angelo Sala, Liboria Siena, Peter M. Henson, Robert C. Murphy, Alessandra Paternò, Anna Bonanno, Loredana Riccobono, Angela Mirabella, Giovanni Bonsignore, and Antonio M. Vignola

Leukotriene B₄ Production in Human Mononuclear Phagocytes Is Modulated by Interleukin-4-Induced 15-Lipoxygenase
J Pharmacol Exp Ther 2002 300: 868-875. [Abstract] [Full Text] [PDF]  

José Eduardo Da Silva-Santos, Maria Cláudia Santos-Silva, Fernando de Queiroz Cunha, and Jamil Assreuy

The Role of ATP-Sensitive Potassium Channels in Neutrophil Migration and Plasma Exudation
J Pharmacol Exp Ther 2002 300: 946-951. [Abstract] [Full Text] [PDF]  

Jochen Graff, Ute Klinkhardt, Valérie B. Schini-Kerth, Sebastian Harder, Nicole Franz, Steffen Bassus, and Carl M. Kirchmaier

Close Relationship between the Platelet Activation Marker CD62 and the Granular Release of Platelet-Derived Growth Factor
J Pharmacol Exp Ther 2002 300: 952-957. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Jae Moon Choi, Hwa Kyoung Shin, Ki Young Kim, Jeong Hyun Lee, and Ki Whan Hong

Neuroprotective Effect of Cilostazol against Focal Cerebral Ischemia via Antiapoptotic Action in Rats
J Pharmacol Exp Ther 2002 300: 787-793. [Abstract] [Full Text] [PDF]  

Barbara L. Waszczak, Lynn P. Martin, Heather E. Finlay, Natalie Zahr, and James R. Stellar

Effects of Individual and Concurrent Stimulation of Striatal D₁ and D₂ Dopamine Receptors on Electrophysiological and Behavioral Output from Rat Basal Ganglia
J Pharmacol Exp Ther 2002 300: 850-861. [Abstract] [Full Text] [PDF]  

Xiu Liu and Friedbert Weiss

Reversal of Ethanol-Seeking Behavior by D1 and D2 Antagonists in an Animal Model of Relapse: Differences in Antagonist Potency in Previously Ethanol-Dependent versus Nondependent Rats
J Pharmacol Exp Ther 2002 300: 882-889. [Abstract] [Full Text] [PDF]  

DeWayne Townsend, IV and David R. Brown

Predominance of -Opioid-Binding Sites in the Porcine Enteric Nervous System
J Pharmacol Exp Ther 2002 300: 900-909. [Abstract] [Full Text] [PDF]  

Christina A. Schad, Joseph B. Justice, Jr., and Stephen G. Holtzman

Endogenous Opioids in Dopaminergic Cell Body Regions Modulate Amphetamine-Induced Increases in Extracellular Dopamine Levels in the Terminal Regions
J Pharmacol Exp Ther 2002 300: 932-938. [Abstract] [Full Text] [PDF]  

Liang Tao and Jiang Hong Ye

Protein Kinase C Modulation of Ethanol Inhibition of Glycine-Activated Current in Dissociated Neurons of Rat Ventral Tegmental Area
J Pharmacol Exp Ther 2002 300: 967-975. [Abstract] [Full Text] [PDF]  

Vincenzo Di Marzo, Graeme Griffin, Luciano De Petrocellis, Ines Brandi, Tiziana Bisogno, William Williams, Mark C. Grier, Sanjitha Kulasegram, Anu Mahadevan, Raj K. Razdan, and Billy R. Martin

A Structure/Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid
J Pharmacol Exp Ther 2002 300: 984-991. [Abstract] [Full Text] [PDF]  

Constance E. Owens and Huda Akil

Determinants of Ligand Selectivity at the -Receptor Based on The Structure of the Orphanin FQ Receptor
J Pharmacol Exp Ther 2002 300: 992-999. [Abstract] [Full Text] [PDF]  

Jost Leemhuis, Stephanie Boutillier, Gudula Schmidt, and Dieter K. Meyer

The Protein Kinase A Inhibitor H89 Acts on Cell Morphology by Inhibiting Rho Kinase
J Pharmacol Exp Ther 2002 300: 1000-1007. [Abstract] [Full Text] [PDF]  

Geng-Chang Yeh, Jin-Chung Chen, Hsiu-Chuan Tsai, Hsueh-Hsia Wu, Chao-Yu Lin, Ping-Ching Hsu, and Yu-Chen Peng

Amphetamine Inhibits the N-Methyl-D-Aspartate Receptor-Mediated Responses by Directly Interacting with The Receptor/Channel Complex
J Pharmacol Exp Ther 2002 300: 1008-1016. [Abstract] [Full Text] [PDF]  

Jianfeng Mei and Gavril W. Pasternak

₁ Receptor Modulation of Opioid Analgesia in the Mouse
J Pharmacol Exp Ther 2002 300: 1070-1074. [Abstract] [Full Text] [PDF]  

Steven C. Stout, Michael J. Owens, and Charles B. Nemeroff

Regulation of Corticotropin-Releasing Factor Neuronal Systems and Hypothalamic-Pituitary-Adrenal Axis Activity by Stress and Chronic Antidepressant Treatment
J Pharmacol Exp Ther 2002 300: 1085-1092. [Abstract] [Full Text] [PDF]  

J. Paul Hansen, Evan L. Riddle, Verónica Sandoval, Jeffrey M. Brown, James W. Gibb, Glen R. Hanson, and Annette E. Fleckenstein

Methylenedioxymethamphetamine Decreases Plasmalemmal and Vesicular Dopamine Transport: Mechanisms and Implications for Neurotoxicity
J Pharmacol Exp Ther 2002 300: 1093-1100. [Abstract] [Full Text] [PDF]  

Claudine Serradeil-Le Gal, Jean Wagnon, Jacques Simiand, Guy Griebel, Colette Lacour, Gilles Guillon, Claude Barberis, Gabrielle Brossard, Philippe Soubrié, Dino Nisato, Marc Pascal, Rebecca Pruss, Bernard Scatton, Jean-Pierre Maffrand, and Gérard Le Fur

Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V_1b Receptor Antagonist
J Pharmacol Exp Ther 2002 300: 1122-1130. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Jason M. Hansen, Katie K. Harris, Martin A. Philbert, and Craig Harris

Thalidomide Modulates Nuclear Redox Status and Preferentially Depletes Glutathione in Rabbit Limb versus Rat Limb
J Pharmacol Exp Ther 2002 300: 768-776. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Effects of Pharmacological Agents upon a Transgenic Model of Parkinson's Disease in Drosophila melanogaster"
J Pharmacol Exp Ther 2002 300: 1131. [Full Text] [PDF]  

Correction to "Interaction of the Sulfonylthiourea HMR 1833 with Sulfonylurea Receptors and Recombinant ATP-Sensitive K⁺ Channels: Comparison with Glibenclamide"
J Pharmacol Exp Ther 2002 300: 1132. [Full Text] [PDF]  

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