PERSPECTIVES IN PHARMACOLOGY:

Ronald N. Hines and D. Gail McCarver

The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes
J Pharmacol Exp Ther 2002 300: 355-360. [Abstract] [Full Text] [PDF]  

D. Gail McCarver and Ronald N. Hines

The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms
J Pharmacol Exp Ther 2002 300: 361-366. [Abstract] [Full Text] [PDF]  

Burkhard Hinz and Kay Brune

Cyclooxygenase-210 Years Later
J Pharmacol Exp Ther 2002 300: 367-375. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Xue-Qing Li, Anders Björkman, Tommy B. Andersson, Marianne Ridderström, and Collen M. Masimirembwa

Amodiaquine Clearance and Its Metabolism to N-Desethylamodiaquine Is Mediated by CYP2C8: A New High Affinity and Turnover Enzyme-Specific Probe Substrate
J Pharmacol Exp Ther 2002 300: 399-407. [Abstract] [Full Text] [PDF]  

Cuiping Chen and Dhiren R. Thakker

The Fallacy of Using Adrenochrome Reaction for Measurement of Reactive Oxygen Species Formed During Cytochrome P450-Mediated Metabolism of Xenobiotics
J Pharmacol Exp Ther 2002 300: 417-420. [Abstract] [Full Text] [PDF]  

Ute M. Kent, Danielle E. Mills, Rajendram V. Rajnarayanan, William L. Alworth, and Paul F. Hollenberg

Effect of 17--Ethynylestradiol on Activities of Cytochrome P450 2B (P450 2B) Enzymes: Characterization of Inactivation of P450s 2B1 and 2B6 and Identification of Metabolites
J Pharmacol Exp Ther 2002 300: 549-558. [Abstract] [Full Text] [PDF]  

Michael Weiss and Wonku Kang

P-Glycoprotein Inhibitors Enhance Saturable Uptake of Idarubicin in Rat Heart: Pharmacokinetic/Pharmacodynamic Modeling
J Pharmacol Exp Ther 2002 300: 688-694. [Abstract] [Full Text] [PDF]  

BEHAVIORAL:

Lance R. McMahon, Lisa R. Gerak, Lawrence Carter, Chunrong Ma, James M. Cook, and Charles P. France

Discriminative Stimulus Effects of Benzodiazepine (BZ)₁ Receptor-Selective Ligands in Rhesus Monkeys
J Pharmacol Exp Ther 2002 300: 505-512. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Elizabeth Connolly, David J. Bouchier-Hayes, Elaine Kaye, Austin Leahy, Desmond Fitzgerald, and Orina Belton

Cyclooxygenase Isozyme Expression and Intimal Hyperplasia in a Rat Model of Balloon Angioplasty
J Pharmacol Exp Ther 2002 300: 393-398. [Abstract] [Full Text] [PDF]  

Walter Raasch, Torsten Bartels, Annabella Gieselberg, Andreas Dendorfer, and Peter Dominiak

Angiotensin I-Converting Enzyme Inhibition Increases Cardiac Catecholamine Content and Reduces Monoamine Oxidase Activity via an Angiotensin Type 1 Receptor-Mediated Mechanism
J Pharmacol Exp Ther 2002 300: 428-434. [Abstract] [Full Text] [PDF]  

Friedrich Brunner, Gerald Wölkart, and Stephen Haleen

Defective Intracellular Calcium Handling in Monocrotaline-Induced Right Ventricular Hypertrophy: Protective Effect of Long-Term Endothelin-A Receptor Blockade with 2-Benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-phenyl-)- 4-oxobut-2-enoate-sodium (PD 155080)
J Pharmacol Exp Ther 2002 300: 442-449. [Abstract] [Full Text] [PDF]  

Dierk Thomas, Bernd Gut, Gunnar Wendt-Nordahl, and Johann Kiehn

The Antidepressant Drug Fluoxetine Is an Inhibitor of Human Ether-A-Go-Go-Related Gene (HERG) Potassium Channels
J Pharmacol Exp Ther 2002 300: 543-548. [Abstract] [Full Text] [PDF]  

Casilde Sesti, M. Johan Broekman, Joan H. F. Drosopoulos, Naziba Islam, Aaron J. Marcus, and Roberto Levi

EctoNucleotidase in Cardiac Sympathetic Nerve Endings Modulates ATP-Mediated Feedback of Norepinephrine Release
J Pharmacol Exp Ther 2002 300: 605-611. [Abstract] [Full Text] [PDF]  

David Godreau, Roger Vranckx, and Stéphane N. Hatem

Mechanisms of Action of Antiarrhythmic Agent Bertosamil on hKv1.5 Channels and Outward Potassium Current in Human Atrial Myocytes
J Pharmacol Exp Ther 2002 300: 612-620. [Abstract] [Full Text] [PDF]  

Mitsuhiko Yamada

The Role of Muscarinic K⁺ Channels in the Negative Chronotropic Effect of a Muscarinic Agonist
J Pharmacol Exp Ther 2002 300: 681-687. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Nicole R. Sullivan Hanley and Julie G. Hensler

Mechanisms of Ligand-Induced Desensitization of the 5-Hydroxytryptamine_2A Receptor
J Pharmacol Exp Ther 2002 300: 468-477. [Abstract] [Full Text] [PDF]  

Wissam H. Joumaa, Aicha Bouhlel, William Même, and Claude Léoty

Methyl Jasmonate-Induced Stimulation of Sarcoplasmic Reticulum Ca²⁺-ATPase Affects Contractile Responses in Rat Slow-Twitch Skeletal Muscle
J Pharmacol Exp Ther 2002 300: 638-646. [Abstract] [Full Text] [PDF]  

Sean G. Brown, Andrea Townsend-Nicholson, Kenneth A. Jacobson, Geoffrey Burnstock, and Brian F. King

Heteromultimeric P2X_1/2 Receptors Show a Novel Sensitivity to Extracellular pH
J Pharmacol Exp Ther 2002 300: 673-680. [Abstract] [Full Text] [PDF]  

Bahjat Al-Ani, Mahmoud Saifeddine, Suranga J. Wijesuriya, and Morley D. Hollenberg

Modified Proteinase-Activated Receptor-1 and -2 Derived Peptides Inhibit Proteinase-Activated Receptor-2 Activation by Trypsin
J Pharmacol Exp Ther 2002 300: 702-708. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Shigeji Matsumoto, Mizuho Ikeda, Toshimi Nishikawa, Shinki Yoshida, Takeshi Tanimoto, Masahiro Ito, Chikako Saiki, and Mamoru Takeda

Excitatory Mechanism of Deflationary Slowly Adapting Pulmonary Stretch Receptors in the Rat Lung
J Pharmacol Exp Ther 2002 300: 597-604. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Iolanda M. Fierro, Jeffery L. Kutok, and Charles N. Serhan

Novel Lipid Mediator Regulators of Endothelial Cell Proliferation and Migration: Aspirin-Triggered-15R-Lipoxin A₄ and Lipoxin A₄
J Pharmacol Exp Ther 2002 300: 385-392. [Abstract] [Full Text] [PDF]  

Ki Young Kim, Byeong Gee Kim, Sun-Ok Kim, Sung-Eun Yoo, Yong-Geun Kwak, Soo-Wan Chae, and Ki Whan Hong

Prevention of Lipopolysaccharide-Induced Apoptosis by (2S,3S,4R)-N"-Cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine, a Benzopyran Analog, in Endothelial Cells
J Pharmacol Exp Ther 2002 300: 535-542. [Abstract] [Full Text] [PDF]  

John J. Haddad, Stephen C. Land, William O. Tarnow-Mordi, Marek Zembala, Danuta Kowalczyk, and Ryszard Lauterbach

Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. I. Differential Regulation of Lipopolysaccharide-Mediated Proinflammatory Cytokine (Interleukin-6 and Tumor Necrosis Factor-) Biosynthesis in Alveolar Epithelial Cells
J Pharmacol Exp Ther 2002 300: 559-566. [Abstract] [Full Text] [PDF]  

John J. Haddad, Stephen C. Land, William O. Tarnow-Mordi, Marek Zembala, Danuta Kowalczyk, and Ryszard Lauterbach

Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. II. Evidence for the Involvement of an Inhibitory-B/Nuclear Factor-B-Sensitive Pathway in Alveolar Epithelial Cells
J Pharmacol Exp Ther 2002 300: 567-576. [Abstract] [Full Text] [PDF]  

Leslie J. Askonas, James F. Kachur, Doreen Villani-Price, Chi-Dean D. Liang, Mark A. Russell, and Walter G. Smith

Pharmacological Characterization of SC-57461A (3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid HCl), a Potent and Selective Inhibitor of Leukotriene A₄ Hydrolase I: In Vitro Studies
J Pharmacol Exp Ther 2002 300: 577-582. [Abstract] [Full Text] [PDF]  

James F. Kachur, Leslie J. Askonas, Doreen Villani-Price, Nayereh Ghoreishi-Haack, Suzanne Won-Kim, Chi-Dean D. Liang, Mark A. Russell, and Walter G. Smith

Pharmacological Characterization of SC-57461A (3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid HCl), a Potent and Selective Inhibitor of Leukotriene A₄ Hydrolase II: In Vivo Studies
J Pharmacol Exp Ther 2002 300: 583-587. [Abstract] [Full Text] [PDF]  

Young Ki Kim, Yoon Young Jang, Eun Sook Han, and Chung Soo Lee

Depressant Effect of Ambroxol on Stimulated Functional Responses and Cell Death in Rat Alveolar Macrophages Exposed to Silica in Vitro
J Pharmacol Exp Ther 2002 300: 629-637. [Abstract] [Full Text] [PDF]  

Lynn D. Hawkins, Sally T. Ishizaka, Pamela McGuinness, Huiming Zhang, Wendy Gavin, Bruce DeCosta, Zhaoyang Meng, Hu Yang, Maureen Mullarkey, Donna W. Young, Hua Yang, Daniel P. Rossignol, Anneliese Nault, Jeffrey Rose, Melinda Przetak, Jesse C. Chow, and Fabian Gusovsky

A Novel Class of Endotoxin Receptor Agonists with Simplified Structure, Toll-Like Receptor 4-Dependent Immunostimulatory Action, and Adjuvant Activity
J Pharmacol Exp Ther 2002 300: 655-661. [Abstract] [Full Text] [PDF]  

Hiroko Matsumoto and Akira Fujii

Tenidap, an Anti-Inflammatory Agent, Inhibits DNA and Collagen Syntheses, Depresses Cell Proliferation, and Lowers Intracellular pH in Cultured Human Gingival Fibroblasts
J Pharmacol Exp Ther 2002 300: 668-672. [Abstract] [Full Text] [PDF]  

Ki Young Kim, Hwa Kyoung Shin, Jae Moon Choi, and Ki Whan Hong

Inhibition of Lipopolysaccharide-Induced Apoptosis by Cilostazol in Human Umbilical Vein Endothelial Cells
J Pharmacol Exp Ther 2002 300: 709-715. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Rüdiger Schulz, Andrea Wehmeyer, and Karin Schulz

Opioid Receptor Types Selectively Cointernalize with G Protein-Coupled Receptor Kinases 2 and 3
J Pharmacol Exp Ther 2002 300: 376-384. [Abstract] [Full Text] [PDF]  

Miao-Kun Sun, Hui Xu, and Daniel L. Alkon

Pharmacological Protection of Synaptic Function, Spatial Learning, and Memory from Transient Hypoxia in Rats
J Pharmacol Exp Ther 2002 300: 408-416. [Abstract] [Full Text] [PDF]  

Victor Pikov and Jean R. Wrathall

Altered Glutamate Receptor Function during Recovery of Bladder Detrusor-External Urethral Sphincter Coordination in a Rat Model of Spinal Cord Injury
J Pharmacol Exp Ther 2002 300: 421-427. [Abstract] [Full Text] [PDF]  

Richard M. Allen, Arthur L. Granger, and Linda A. Dykstra

Dextromethorphan Potentiates the Antinociceptive Effects of Morphine and the -Opioid Agonist SNC80 in Squirrel Monkeys
J Pharmacol Exp Ther 2002 300: 435-441. [Abstract] [Full Text] [PDF]  

Aino Kankaanpää, Satu Ellermaa, Esa Meririnne, Paula Hirsjärvi, and Timo Seppälä

Acute Neurochemical and Behavioral Effects of Stereoisomers of 4-Methylaminorex in Relation to Brain Drug Concentrations
J Pharmacol Exp Ther 2002 300: 450-459. [Abstract] [Full Text] [PDF]  

Arthur A. Hancock, Steven A. Buckner, Michael E. Brune, Timothy A. Esbenshade, Lynne M. Ireland, Sweta Katwala, Ivan Milicic, Michael D. Meyer, James F. Kerwin, Jr., and Michael Williams

Preclinical Pharmacology of Fiduxosin, a Novel ₁-Adrenoceptor Antagonist with Uroselective Properties
J Pharmacol Exp Ther 2002 300: 478-486. [Abstract] [Full Text] [PDF]  

Michael E. Brune, Sweta P. Katwala, Ivan Milicic, David G. Witte, James F. Kerwin, Jr., Michael D. Meyer, Arthur A. Hancock, and Michael Williams

Effect of Fiduxosin, an Antagonist Selective for _1A- and _1D-Adrenoceptors, on Intraurethral and Arterial Pressure Responses in Conscious Dogs
J Pharmacol Exp Ther 2002 300: 487-494. [Abstract] [Full Text] [PDF]  

David G. Witte, Michael E. Brune, Sweta P. Katwala, Ivan Milicic, Deanne Stolarik, Yu-Hua Hui, Kennan C. Marsh, James F. Kerwin, Jr., Michael D. Meyer, and Arthur A. Hancock

Modeling of Relationships between Pharmacokinetics and Blockade of Agonist-Induced Elevation of Intraurethral Pressure and Mean Arterial Pressure in Conscious Dogs Treated with ₁-Adrenoceptor Antagonists
J Pharmacol Exp Ther 2002 300: 495-504. [Abstract] [Full Text] [PDF]  

Yun Guan, Ryuji Terayama, Ronald Dubner, and Ke Ren

Plasticity in Excitatory Amino Acid Receptor-Mediated Descending Pain Modulation after Inflammation
J Pharmacol Exp Ther 2002 300: 513-520. [Abstract] [Full Text] [PDF]  

Yongxin Yu and Michael C. Koss

_1A-Adrenoceptors Mediate Sympathetically Evoked Pupillary Dilation in Rats
J Pharmacol Exp Ther 2002 300: 521-525. [Abstract] [Full Text] [PDF]  

G. S. Findlay, M. J. Wick, M. P. Mascia, D. Wallace, G. W. Miller, R. A. Harris, and Y. A. Blednov

Transgenic Expression of a Mutant Glycine Receptor Decreases Alcohol Sensitivity of Mice
J Pharmacol Exp Ther 2002 300: 526-534. [Abstract] [Full Text] [PDF]  

Kelly J. Powell, Noura S. Abul-Husn, Asha Jhamandas, Mary C. Olmstead, Richard J. Beninger, and Khem Jhamandas

Paradoxical Effects of the Opioid Antagonist Naltrexone on Morphine Analgesia, Tolerance, and Reward in Rats
J Pharmacol Exp Ther 2002 300: 588-596. [Abstract] [Full Text] [PDF]  

S. Morisset, C. Pilon, J. Tardivel-Lacombe, D. Weinstein, W. Rostene, C. Betancur, P. Sokoloff, J.-C. Schwartz, and J.-M. Arrang

Acute and Chronic Effects of Methamphetamine on Tele-Methylhistamine Levels in Mouse Brain: Selective Involvement of the D₂ and not D₃ Receptor
J Pharmacol Exp Ther 2002 300: 621-628. [Abstract] [Full Text] [PDF]  

Hsiang-en Wu, Kuei-chun Hung, Hirokazu Mizoguchi, Hiroshi Nagase, and Leon F. Tseng

Roles of Endogenous Opioid Peptides in Modulation of Nocifensive Response to Formalin
J Pharmacol Exp Ther 2002 300: 647-654. [Abstract] [Full Text] [PDF]  

Shao-Rui Chen, Krystyna M. Wozniak, Barbara S. Slusher, and Hui-Lin Pan

Effect of 2-(Phosphono-methyl)-pentanedioic Acid on Allodynia and Afferent Ectopic Discharges in a Rat Model of Neuropathic Pain
J Pharmacol Exp Ther 2002 300: 662-667. [Abstract] [Full Text] [PDF]  

Theodore J. Cicero, Bruce Nock, Lynn O'Connor, and Edward R. Meyer

Role of Steroids in Sex Differences in Morphine-Induced Analgesia: Activational and Organizational Effects
J Pharmacol Exp Ther 2002 300: 695-701. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

John P. Buchweitz, Patricia E. Ganey, Steven J. Bursian, and Robert A. Roth

Underlying Endotoxemia Augments Toxic Responses to Chlorpromazine: Is There a Relationship to Drug Idiosyncrasy?
J Pharmacol Exp Ther 2002 300: 460-467. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Liver Targeting of Interferon- with a Liver-Affinity Polysaccharide Based on Metal Coordination in Mice"
J Pharmacol Exp Ther 2002 300: 716. [Full Text] [PDF]  

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