PERSPECTIVES IN PHARMACOLOGY:

Thomas J. Martin and James C. Eisenach

Pharmacology of Opioid and Nonopioid Analgesics in Chronic Pain States
J Pharmacol Exp Ther 2001 299: 811-817. [Abstract] [Full Text] [PDF]  

David Fulton, Jean-Philippe Gratton, and William C. Sessa

Post-Translational Control of Endothelial Nitric Oxide Synthase: Why Isn't Calcium/Calmodulin Enough?
J Pharmacol Exp Ther 2001 299: 818-824. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Diana Dai, Jun Tang, Randy Rose, Ernest Hodgson, Rachelle J. Bienstock, Harvey W. Mohrenweiser, and Joyce A. Goldstein

Identification of Variants of CYP3A4 and Characterization of Their Abilities to Metabolize Testosterone and Chlorpyrifos
J Pharmacol Exp Ther 2001 299: 825-831. [Abstract] [Full Text] [PDF]  

James M. Rae, Michael D. Johnson, Marc E. Lippman, and David A. Flockhart

Rifampin Is a Selective, Pleiotropic Inducer of Drug Metabolism Genes in Human Hepatocytes: Studies with cDNA and Oligonucleotide Expression Arrays
J Pharmacol Exp Ther 2001 299: 849-857. [Abstract] [Full Text] [PDF]  

Thomas K. H. Chang, Jie Chen, and Wendy B. K. Lee

Differential Inhibition and Inactivation of Human CYP1 Enzymes by trans-Resveratrol: Evidence for Mechanism-Based Inactivation of CYP1A2
J Pharmacol Exp Ther 2001 299: 874-882. [Abstract] [Full Text] [PDF]  

R. D. Egleton, S. A. Mitchell, J. D. Huber, M. M. Palian, R. Polt, and T. P. Davis

Improved Blood-Brain Barrier Penetration and Enhanced Analgesia of an Opioid Peptide by Glycosylation
J Pharmacol Exp Ther 2001 299: 967-972. [Abstract] [Full Text] [PDF]  

Michael H. Court, Su X. Duan, Lisa L. von Moltke, David J. Greenblatt, Christopher J. Patten, John O. Miners, and Peter I. Mackenzie

Interindividual Variability in Acetaminophen Glucuronidation by Human Liver Microsomes: Identification of Relevant Acetaminophen UDP-Glucuronosyltransferase Isoforms
J Pharmacol Exp Ther 2001 299: 998-1006. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Anthony W. Bannon, Jennifer Seda, Michelle Carmouche, Jonathan M. Francis, Mark A. Jarosinski, and James Douglass

Multiple Behavioral Effects of Cocaine- and Amphetamine-Regulated Transcript (CART) Peptides in Mice: CART 42-89 and CART 49-89 Differ in Potency and Activity
J Pharmacol Exp Ther 2001 299: 1021-1026. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Mostafa Khalid, Yves Giudicelli, and Jean-Pierre Dausse

An Up-Regulation of Renal ₂A-Adrenoceptors Is Associated with Resistance to Salt-Induced Hypertension in Sabra Rats
J Pharmacol Exp Ther 2001 299: 928-933. [Abstract] [Full Text] [PDF]  

Franck Potet, Thierry Bouyssou, Denis Escande, and Isabelle Baró

Gastrointestinal Prokinetic Drugs have Different Affinity for the Human Cardiac Human Ether-à-gogo K⁺ Channel
J Pharmacol Exp Ther 2001 299: 1007-1012. [Abstract] [Full Text] [PDF]  

Ulrich Russ, Ulf Lange, Cornelia Löffler-Walz, Annette Hambrock, and Ulrich Quast

Interaction of the Sulfonylthiourea HMR 1833 with Sulfonylurea Receptors and Recombinant ATP-Sensitive K⁺ Channels: Comparison with Glibenclamide
J Pharmacol Exp Ther 2001 299: 1049-1055. [Abstract] [Full Text] [PDF]  

J.-C. Tille, J. Wood, S.J. Mandriota, C. Schnell, S. Ferrari, J. Mestan, Z. Zhu, L. Witte, and M. S. Pepper

Vascular Endothelial Growth Factor (VEGF) Receptor-2 Antagonists Inhibit VEGF- and Basic Fibroblast Growth Factor-Induced Angiogenesis in Vivo and in Vitro
J Pharmacol Exp Ther 2001 299: 1073-1085. [Abstract] [Full Text] [PDF]  

Boyd R. Rorabaugh, Margaret A. Scofield, D. David Smith, William B. Jeffries, and Peter W. Abel

Functional Calcitonin Gene-Related Peptide Subtype 2 Receptors in Porcine Coronary Arteries Are Identified as Calcitonin Gene-Related Peptide Subtype 1 Receptors by Radioligand Binding and Reverse Transcription-Polymerase Chain Reaction
J Pharmacol Exp Ther 2001 299: 1086-1094. [Abstract] [Full Text] [PDF]  

Xavier Monnet, Bijan Ghaleh, Patrice Colin, Olivier Parent de Curzon, Jean-François Giudicelli, and Alain Berdeaux

Effects of Heart Rate Reduction with Ivabradine on Exercise-Induced Myocardial Ischemia and Stunning
J Pharmacol Exp Ther 2001 299: 1133-1139. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Yoshifumi Kawanabe, Nobuo Hashimoto, Tomoh Masaki, and Soichi Miwa

Ca²⁺ Influx through Nonselective Cation Channels Plays an Essential Role in Noradrenaline-Induced Arachidonic Acid Release in Chinese Hamster Ovary Cells Expressing _1A-, _1B-, or _1D-Adrenergic Receptors
J Pharmacol Exp Ther 2001 299: 901-907. [Abstract] [Full Text] [PDF]  

Kerstin Wieland, Gerold Bongers, Yumiko Yamamoto, Takeshi Hashimoto, Atsushi Yamatodani, Wiro M. B. P. Menge, Henk Timmerman, Timothy W. Lovenberg, and Rob Leurs

Constitutive Activity of Histamine H₃ Receptors Stably Expressed in SK-N-MC Cells: Display of Agonism and Inverse Agonism by H₃ Antagonists
J Pharmacol Exp Ther 2001 299: 908-914. [Abstract] [Full Text] [PDF]  

Stig O. P. Jacobsson, Thomas Wallin, and Christopher J. Fowler

Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors
J Pharmacol Exp Ther 2001 299: 951-959. [Abstract] [Full Text] [PDF]  

Iustin V. Tabarean and Toshio Narahashi

Kinetics of Modulation of Tetrodotoxin-Sensitive and Tetrodotoxin-Resistant Sodium Channels by Tetramethrin and Deltamethrin
J Pharmacol Exp Ther 2001 299: 988-997. [Abstract] [Full Text] [PDF]  

Katharina Wenzel-Seifert, Melissa T. Kelley, Armin Buschauer, and Roland Seifert

Similar Apparent Constitutive Activity of Human Histamine H₂-Receptor Fused to Long and Short Splice Variants of G_s
J Pharmacol Exp Ther 2001 299: 1013-1020. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Saadia B. Hassan, Elin Jonsson, Rolf Larsson, and Mats O. Karlsson

Model for Time Dependency of Cytotoxic Effect of CHS 828 in Vitro Suggests Two Different Mechanisms of Action
J Pharmacol Exp Ther 2001 299: 1140-1147. [Abstract] [Full Text] [PDF]  

Terry W. Moody and Robert T. Jensen

CI-988 Inhibits Growth of Small Cell Lung Cancer Cells
J Pharmacol Exp Ther 2001 299: 1154-1160. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Cristina G. Cintado, Francisco M. Pinto, Philippe Devillier, Angel Merida, and M. Luz Candenas

Increase in Neurokinin B Expression and in Tachykinin NK₃ Receptor-Mediated Response and Expression in the Rat Uterus with Age
J Pharmacol Exp Ther 2001 299: 934-938. [Abstract] [Full Text] [PDF]  

Stevan P. Tofovic, Raghvendra K. Dubey, and Edwin K. Jackson

2-Hydroxyestradiol Attenuates the Development of Obesity, the Metabolic Syndrome, and Vascular and Renal Dysfunction in Obese ZSF1 Rats
J Pharmacol Exp Ther 2001 299: 973-977. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Zhi Zhong, Xiangli Li, Shunhei Yamashina, Moritz von Frankenberg, Nobuyuki Enomoto, Kenichi Ikejima, Monica Kolinsky, James A. Raleigh, and Ronald G. Thurman

Cyclosporin A Causes a Hypermetabolic State and Hypoxia in the Liver: Prevention by Dietary Glycine
J Pharmacol Exp Ther 2001 299: 858-865. [Abstract] [Full Text] [PDF]  

Hajime Higuchi, Hideyuki Miyoshi, Steven F. Bronk, Hong Zhang, Nicholas Dean, and Gregory J. Gores

Bid Antisense Attenuates Bile Acid-Induced Apoptosis and Cholestatic Liver Injury
J Pharmacol Exp Ther 2001 299: 866-873. [Abstract] [Full Text] [PDF]  

Francesco Giuliano, Jane A. Mitchell, and Timothy D. Warner

Sodium Salicylate Inhibits Prostaglandin Formation without Affecting the Induction of Cyclooxygenase-2 by Bacterial Lipopolysaccharide in Vivo
J Pharmacol Exp Ther 2001 299: 894-900. [Abstract] [Full Text] [PDF]  

Yusuf Ergün and Nuran Öülener

Evidence for the Interaction between Nitric Oxide and Vasoactive Intestinal Polypeptide in the Mouse Gastric Fundus
J Pharmacol Exp Ther 2001 299: 945-950. [Abstract] [Full Text] [PDF]  

Edwin K. Jackson, Curtis K. Kost, Jr., William A. Herzer, Glenn J. Smits, and Stevan P. Tofovic

A₁ Receptor Blockade Induces Natriuresis with a Favorable Renal Hemodynamic Profile in SHHF/Mcc-fa^cp Rats Chronically Treated with Salt and Furosemide
J Pharmacol Exp Ther 2001 299: 978-987. [Abstract] [Full Text] [PDF]  

A. Leonardi, L. Guarneri, E. Poggesi, P. Angelico, C. Velasco, A. Cilia, and R. Testa

N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) Cyclohexanecarboxamide: A Novel Pre- and Postsynaptic 5-Hydroxytryptamine_1A Receptor Antagonist Active on the Lower Urinary Tract
J Pharmacol Exp Ther 2001 299: 1027-1037. [Abstract] [Full Text] [PDF]  

Frederick J. Ehlert, Khurram Z. Ansari, Darakhshanda Shehnaz, Gregory W. Sawyer, and Michael T. Griffin

Acetylcholine-Induced Desensitization of Muscarinic Contractile Response in Guinea Pig Ileum Is Inhibited by Pertussis Toxin Treatment
J Pharmacol Exp Ther 2001 299: 1126-1132. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Leo R. Fitzpatrick, Jian Wang, and Truc Le

Caffeic Acid Phenethyl Ester, an Inhibitor of Nuclear Factor-B, Attenuates Bacterial Peptidoglycan Polysaccharide-Induced Colitis in Rats
J Pharmacol Exp Ther 2001 299: 915-920. [Abstract] [Full Text] [PDF]  

Takeshi Kubota, Jidong Fang, Leonard T. Meltzer, and James M. Krueger

Pregabalin Enhances Nonrapid Eye Movement Sleep
J Pharmacol Exp Ther 2001 299: 1095-1105. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Leslie J. Vogt, Laura J. Sim-Selley, Steven R. Childers, Ronald G. Wiley, and Brent A. Vogt

Colocalization of µ-Opioid Receptors and Activated G-Proteins in Rat Cingulate Cortex
J Pharmacol Exp Ther 2001 299: 840-848. [Abstract] [Full Text] [PDF]  

Lucy Rënyi, John L. Evenden, Christopher J. Fowler, Eva Jerning, Diana Kelder, Desmond Lake-Bakaar, Lars-Gunnar Larsson, Nina Mohell, Maria Sällemark, and Svante B. Ross

The Pharmacological Profile of (R)-3,4-Dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a Selective 5-Hydroxytryptamine_1A Receptor Agonist
J Pharmacol Exp Ther 2001 299: 883-893. [Abstract] [Full Text] [PDF]  

Xinhui Li and James C. Eisenach

2A-Adrenoceptor Stimulation Reduces Capsaicin-Induced Glutamate Release from Spinal Cord Synaptosomes
J Pharmacol Exp Ther 2001 299: 939-944. [Abstract] [Full Text] [PDF]  

Christopher L. Douglas, Helen A. Baghdoyan, and Ralph Lydic

M2 Muscarinic Autoreceptors Modulate Acetylcholine Release in Prefrontal Cortex of C57BL/6J Mouse
J Pharmacol Exp Ther 2001 299: 960-966. [Abstract] [Full Text] [PDF]  

Cynthia L. Gentry and Ronald J. Lukas

Local Anesthetics Noncompetitively Inhibit Function of Four Distinct Nicotinic Acetylcholine Receptor Subtypes
J Pharmacol Exp Ther 2001 299: 1038-1048. [Abstract] [Full Text] [PDF]  

Lisa A. Marsch, Warren K. Bickel, Gary J. Badger, James P. Rathmell, Michael D. B. Swedberg, Bror Jonzon, and Carina Norsten-Höög

Effects of Infusion Rate of Intravenously Administered Morphine on Physiological, Psychomotor, and Self-Reported Measures in Humans
J Pharmacol Exp Ther 2001 299: 1056-1065. [Abstract] [Full Text] [PDF]  

Vincent J. Aloyo, Kuldip D. Dave, Tariq Rahman, and John A. Harvey

Selective and Divergent Regulation of Cortical 5-HT_2A Receptors in Rabbit
J Pharmacol Exp Ther 2001 299: 1066-1072. [Abstract] [Full Text] [PDF]  

Manuela Marcoli, Christian Rosu, Andrea Bonfanti, Maurizio Raiteri, and Guido Maura

Inhibitory Presynaptic 5-Hydroxytryptamine_2A Receptors Regulate Evoked Glutamate Release from Rat Cerebellar Mossy Fibers
J Pharmacol Exp Ther 2001 299: 1106-1111. [Abstract] [Full Text] [PDF]  

Tina K. Machu, Margaret E. Hamilton, Tonia F. Frye, Christopher L. Shanklin, Michael C. Harris, Hongwei Sun, Thomas E. Tenner, Jr., Ferenc S. Soti, and William R. Kem

Benzylidene Analogs of Anabaseine Display Partial Agonist and Antagonist Properties at the Mouse 5-Hydroxytryptamine_3A Receptor
J Pharmacol Exp Ther 2001 299: 1112-1119. [Abstract] [Full Text] [PDF]  

Hsiang-en Wu, Kuei-chun Hung, Hirokazu Mizoguchi, James M. Fujimoto, and Leon F. Tseng

Acute Antinociceptive Tolerance and Asymmetric Cross-Tolerance between Endomorphin-1 and Endomorphin-2 Given Intracerebroventricularly in the Mouse
J Pharmacol Exp Ther 2001 299: 1120-1125. [Abstract] [Full Text] [PDF]  

Ashok K. Mehta, Nicole M. Muschaweck, Dean Y. Maeda, Andrew Coop, and Maharaj K. Ticku

Binding Characteristics of the -Hydroxybutyric Acid Receptor Antagonist [³H](2E)-(5-Hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) Ethanoic Acid in the Rat Brain
J Pharmacol Exp Ther 2001 299: 1148-1153. [Abstract] [Full Text] [PDF]  

Jean-Yves Chatton, Jeffrey R. Idle, Cathrine Broberg Vågbø, and Pierre J. Magistretti

Insights into the Mechanisms of Ifosfamide Encephalopathy: Drug Metabolites Have Agonistic Effects on -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)/Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons
J Pharmacol Exp Ther 2001 299: 1161-1168. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Amin A. Nanji, Kalle Jokelainen, George K. K. Lau, Amir Rahemtulla, George L. Tipoe, Rathnagiri Polavarapu, and El-Nasir Lalani

Arginine Reverses Ethanol-Induced Inflammatory and Fibrotic Changes in Liver Despite Continued Ethanol Administration
J Pharmacol Exp Ther 2001 299: 832-839. [Abstract] [Full Text] [PDF]  

Peter A. C. 't Hoen, Martin K. Bijsterbosch, Theo J. C. van Berkel, Nico P. E. Vermeulen, and Jan N. M. Commandeur

Midazolam Is a Phenobarbital-Like Cytochrome P450 Inducer in Rats
J Pharmacol Exp Ther 2001 299: 921-927. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "A Pharmacodynamic Analysis of Erythropoietin-Stimulated Reticulocyte Response in Phlebotomized Sheep"
J Pharmacol Exp Ther 2001 299: 1169. [Full Text] [PDF]  

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