PERSPECTIVES IN PHARMACOLOGY:

Andrea D. Eckhart and Walter J. Koch

Transgenic Studies of Cardiac Adrenergic Receptor Regulation
J Pharmacol Exp Ther 2001 299: 1-5. [Abstract] [Full Text] [PDF]  

Tinna M. Laughlin, Alice A. Larson, and George L. Wilcox

Mechanisms of Induction of Persistent Nociception by Dynorphin
J Pharmacol Exp Ther 2001 299: 6-11. [Abstract] [Full Text] [PDF]  

Darryle D. Schoepp

Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System
J Pharmacol Exp Ther 2001 299: 12-20. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Sean K. Kelley, Louise A. Harris, David Xie, Laura DeForge, Klara Totpal, Jeanine Bussiere, and Judith A. Fox

Preclinical Studies to Predict the Disposition of Apo2L/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Humans: Characterization of in Vivo Efficacy, Pharmacokinetics, and Safety
J Pharmacol Exp Ther 2001 299: 31-38. [Abstract] [Full Text] [PDF]  

Cheng-Chung Tsao, Sherry J. Coulter, Anna Chien, Gang Luo, Natasha P. Clayton, Robert Maronpot, Joyce A. Goldstein, and Darryl C. Zeldin

Identification and Localization of Five CYP2Cs in Murine Extrahepatic Tissues and Their Metabolism of Arachidonic Acid to Regio- and Stereoselective Products
J Pharmacol Exp Ther 2001 299: 39-47. [Abstract] [Full Text] [PDF]  

Ayako Takeuchi, Satohiro Masuda, Hideyuki Saito, Takaaki Abe, and Ken-ichi Inui

Multispecific Substrate Recognition of Kidney-Specific Organic Anion Transporters OAT-K1 and OAT-K2
J Pharmacol Exp Ther 2001 299: 261-267. [Abstract] [Full Text] [PDF]  

Uwe Wenzel, Sabine Kuntz, and Hannelore Daniel

Flavonoids with Epidermal Growth Factor-Receptor Tyrosine Kinase Inhibitory Activity Stimulate PEPT1-Mediated Cefixime Uptake into Human Intestinal Epithelial Cells
J Pharmacol Exp Ther 2001 299: 351-357. [Abstract] [Full Text] [PDF]  

Yan Shu, Carlo L. Bello, Lara M. Mangravite, Bo Feng, and Kathleen M. Giacomini

Functional Characteristics and Steroid Hormone-Mediated Regulation of an Organic Cation Transporter in Madin-Darby Canine Kidney Cells
J Pharmacol Exp Ther 2001 299: 392-398. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Maria Wågberg, Anne-Heléne Jansson, Christer Westerlund, Ann-Margret Östlund-Lindqvist, Bengt Särnstrand, Håkan Bergstrand, and Knut Pettersson

N,N'-Diacetyl-L-cystine (DiNAC), the Disulphide Dimer of N-Acetylcysteine, Inhibits Atherosclerosis in WHHL Rabbits: Evidence for Immunomodulatory Agents as a New Approach to Prevent Atherosclerosis
J Pharmacol Exp Ther 2001 299: 76-82. [Abstract] [Full Text] [PDF]  

Scott Ferreira, William J. Crumb, Jr., Carol G. Carlton, and Craig W. Clarkson

Effects of Cocaine and Its Major Metabolites on the HERG-Encoded Potassium Channel
J Pharmacol Exp Ther 2001 299: 220-226. [Abstract] [Full Text] [PDF]  

Jiesheng Kang, Xiao-Liang Chen, Lin Wang, and David Rampe

Interactions of the Antimalarial Drug Mefloquine with the Human Cardiac Potassium Channels KvLQT1/minK and HERG
J Pharmacol Exp Ther 2001 299: 290-296. [Abstract] [Full Text] [PDF]  

Richard D. Bukoski, Simoneque Shearin, William F. Jackson, and Mohan F. Pamarthi

Inhibition of Ca²⁺-Induced Relaxation by Oxidized Tungsten Wires and Paratungstate
J Pharmacol Exp Ther 2001 299: 343-350. [Abstract] [Full Text] [PDF]  

Hercule Hantz, Ajayi Adesuyi, and Oyekan Adebayo

Differential Effects of U46619 on Renal Regional Hemodynamics in the Rat: Involvement of Endothelin
J Pharmacol Exp Ther 2001 299: 372-376. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Nancy J. Linford, Yaxiong Yang, David G. Cook, and Daniel M. Dorsa

Neuronal Apoptosis Resulting from High Doses of the Isoflavone Genistein: Role for Calcium and P42/44 Mitogen-Activated Protein Kinase
J Pharmacol Exp Ther 2001 299: 67-75. [Abstract] [Full Text] [PDF]  

Virgile Visentin, Nathalie Morin, Emi Fontana, Danielle Prévot, Jeremie Boucher, Isabelle Castan, Philippe Valet, Danica Grujic, and Christian Carpéné

Dual Action of Octopamine on Glucose Transport into Adipocytes: Inhibition via ₃-Adrenoceptor Activation and Stimulation via Oxidation by Amine Oxidases
J Pharmacol Exp Ther 2001 299: 96-104. [Abstract] [Full Text] [PDF]  

Thomas Suply, Odile Della Zuana, Valérie Audinot, Marianne Rodriguez, Philippe Beauverger, Jacques Duhault, Emmanuel Canet, Jean-Pierre Galizzi, Jean-Louis Nahon, Nigel Levens, and Jean A. Boutin

SLC-1 Receptor Mediates Effect of Melanin-Concentrating Hormone on Feeding Behavior in Rat: A Structure-Activity Study
J Pharmacol Exp Ther 2001 299: 137-146. [Abstract] [Full Text] [PDF]  

Habib R. Ansari, Shahid Husain, and Ata A. Abdel-Latif

Activation of p42/p44 Mitogen-Activated Protein Kinase and Contraction by Prostaglandin F₂, Ionomycin, and Thapsigargin in Cat Iris Sphincter Smooth Muscle: Inhibition by PD98059, KN-93, and Isoproterenol
J Pharmacol Exp Ther 2001 299: 178-186. [Abstract] [Full Text] [PDF]  

Edward F. Nemeth, Eric G. Delmar, William L. Heaton, Michael A. Miller, Lyssa D. Lambert, Rebecca L. Conklin, Maxine Gowen, John G. Gleason, Pradip K. Bhatnagar, and John Fox

Calcilytic Compounds: Potent and Selective Ca²⁺ Receptor Antagonists That Stimulate Secretion of Parathyroid Hormone
J Pharmacol Exp Ther 2001 299: 323-331. [Abstract] [Full Text] [PDF]  

Michael J. Parker, Scott C. Harvey, and Charles W. Luetje

Determinants of Agonist Binding Affinity on Neuronal Nicotinic Receptor Subunits
J Pharmacol Exp Ther 2001 299: 385-391. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Beverley Greenwood-Van Meerveld, Kalina Venkova, and James C. Keith, Jr.

Recombinant Human Interleukin-11 Restores Smooth Muscle Function in the Jejunum and Colon of Human Leukocyte Antigen-B27 Rats with Intestinal Inflammation
J Pharmacol Exp Ther 2001 299: 58-66. [Abstract] [Full Text] [PDF]  

Wei Ming Sun, William L. Hasler, Han-Chung Lien, Jared Montague, and Chung Owyang

Nizatidine Enhances the Gastrocolonic Response and the Colonic Peristaltic Reflex in Humans
J Pharmacol Exp Ther 2001 299: 159-163. [Abstract] [Full Text] [PDF]  

Jan Taipalensuu, Hans Törnblom, Greger Lindberg, Curt Einarsson, Folke Sjöqvist, Håkan Melhus, Per Garberg, Brita Sjöström, Bo Lundgren, and Per Artursson

Correlation of Gene Expression of Ten Drug Efflux Proteins of the ATP-Binding Cassette Transporter Family in Normal Human Jejunum and in Human Intestinal Epithelial Caco-2 Cell Monolayers
J Pharmacol Exp Ther 2001 299: 164-170. [Abstract] [Full Text] [PDF]  

Alessandro Lecci, Francesca Carini, Manuela Tramontana, Vincenzo D'Aranno, Erica Marinoni, Attilio Crea, Lionel Bueno, Jean Fioramonti, Marco Criscuoli, Sandro Giuliani, and Carlo Alberto Maggi

Nepadutant Pharmacokinetics and Dose-Effect Relationships as Tachykinin NK₂ Receptor Antagonist Are Altered by Intestinal Inflammation in Rodent Models
J Pharmacol Exp Ther 2001 299: 247-254. [Abstract] [Full Text] [PDF]  

Nadeem R. Janjua, Thomas E. N. Jonassen, Susanna Langhoff, Klaus Thomsen, and Sten Christensen

Role of Sodium Depletion in Acute Antidiuretic Effect of Bendroflumethiazide in Rats with Nephrogenic Diabetes Insipidus
J Pharmacol Exp Ther 2001 299: 307-313. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Richard L. Auten, Ricardo M. Richardson, John R. White, S. Nicholas Mason, Michael A. Vozzelli, and Mary H. Whorton

Nonpeptide CXCR2 Antagonist Prevents Neutrophil Accumulation in Hyperoxia-Exposed Newborn Rats
J Pharmacol Exp Ther 2001 299: 90-95. [Abstract] [Full Text] [PDF]  

Changlu Liu, Sandy J. Wilson, Chester Kuei, and Timothy W. Lovenberg

Comparison of Human, Mouse, Rat, and Guinea Pig Histamine H₄ Receptors Reveals Substantial Pharmacological Species Variation
J Pharmacol Exp Ther 2001 299: 121-130. [Abstract] [Full Text] [PDF]  

David G. Perregaux, Patricia McNiff, Ronald Laliberte, Natalie Hawryluk, Heather Peurano, Ethan Stam, Jim Eggler, Richard Griffiths, Mark A. Dombroski, and Christopher A. Gabel

Identification and Characterization of a Novel Class of Interleukin-1 Post-Translational Processing Inhibitors
J Pharmacol Exp Ther 2001 299: 187-197. [Abstract] [Full Text] [PDF]  

Michael J. Coffey, Susan M. Phare, and Marc Peters-Golden

Peroxynitrite-Induced Nitrotyrosination of Proteins Is Blocked by Direct 5-Lipoxygenase Inhibitor Zileuton
J Pharmacol Exp Ther 2001 299: 198-203. [Abstract] [Full Text] [PDF]  

Bruce S. Fischer, Danmei Qin, Kami Kim, and Thomas V. McDonald

Capsaicin Inhibits Jurkat T-Cell Activation by Blocking Calcium Entry Current I_CRAC
J Pharmacol Exp Ther 2001 299: 238-246. [Abstract] [Full Text] [PDF]  

Denis J. Dupré, Christian Le Gouill, Marek Rola-Pleszczynski, and Jana Staková

Inverse Agonist Activity of Selected Ligands of Platelet-Activating Factor Receptor
J Pharmacol Exp Ther 2001 299: 358-365. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Edward J. Wagner, Oline K. Rønnekleiv, and Martin J. Kelly

The Noradrenergic Inhibition of an Apamin-Sensitive, Small-Conductance Ca²⁺-Activated K⁺ Channel in Hypothalamic -Aminobutyric Acid Neurons: Pharmacology, Estrogen Sensitivity, and Relevance to the Control of the Reproductive Axis
J Pharmacol Exp Ther 2001 299: 21-30. [Abstract] [Full Text] [PDF]  

A. J. Williams, X. M. Lu, B. Slusher, and F. C. Tortella

Electroencephalogram Analysis and Neuroprotective Profile of the N-Acetylated--Linked Acidic Dipeptidase Inhibitor, GPI5232, in Normal and Brain-Injured Rats
J Pharmacol Exp Ther 2001 299: 48-57. [Abstract] [Full Text] [PDF]  

Laura Rauser, Jason E. Savage, Herbert Y. Meltzer, and Bryan L. Roth

Inverse Agonist Actions of Typical and Atypical Antipsychotic Drugs at the Human 5-Hydroxytryptamine_2C Receptor
J Pharmacol Exp Ther 2001 299: 83-89. [Abstract] [Full Text] [PDF]  

Elizabeth H. Kamp, Daniel R. Beck, and G. F. Gebhart

Combinations of Neurokinin Receptor Antagonists Reduce Visceral Hyperalgesia
J Pharmacol Exp Ther 2001 299: 105-113. [Abstract] [Full Text] [PDF]  

Rachel L. Peltier, Glenn F. Guerin, Nandakumar Dorairaj, and Nick E. Goeders

Effects of Saline Substitution on Responding and Plasma Corticosterone in Rats Trained to Self-Administer Different Doses of Cocaine
J Pharmacol Exp Ther 2001 299: 114-120. [Abstract] [Full Text] [PDF]  

Okan Cinkilic, Brian F. King, Markus van der Giet, Hartmut Schlüter, Walter Zidek, and Geoffrey Burnstock

Selective Agonism of Group I P2X Receptors by Dinucleotides Dependent on a Single Adenine Moiety
J Pharmacol Exp Ther 2001 299: 131-136. [Abstract] [Full Text] [PDF]  

Sharon L. Walsh, Beth Geter-Douglas, Eric C. Strain, and George E. Bigelow

Enadoline and Butorphanol: Evaluation of -Agonists on Cocaine Pharmacodynamics and Cocaine Self-Administration in Humans
J Pharmacol Exp Ther 2001 299: 147-158. [Abstract] [Full Text] [PDF]  

Kiyonori Kishimoto, Shin-Ichiro Matsuo, Yumiko Kanemoto, Hitoshi Ishibashi, Yasuo Oyama, and Norio Akaike

Nanomolar Concentrations of Tri-n-butyltin Facilitate -Aminobutyric Acidergic Synaptic Transmission in Rat Hypothalamic Neurons
J Pharmacol Exp Ther 2001 299: 171-177. [Abstract] [Full Text] [PDF]  

Gloria Lee, Lyanne Schlichter, Moise Bendayan, and Reina Bendayan

Functional Expression of P-glycoprotein in Rat Brain Microglia
J Pharmacol Exp Ther 2001 299: 204-212. [Abstract] [Full Text] [PDF]  

Makoto Inoue, Shinobu Matsunaga, M. Harunor Rashid, Akira Yoshida, Kiyonobu Mizuno, Tsukasa Sakurada, Hiroshi Takeshima, and Hiroshi Ueda

Pronociceptive Effects of Nociceptin/Orphanin FQ (13-17) at Peripheral and Spinal Level in Mice
J Pharmacol Exp Ther 2001 299: 213-219. [Abstract] [Full Text] [PDF]  

Lin Xu, Judith A. Enyeart, and John J. Enyeart

Neuroprotective Agent Riluzole Dramatically Slows Inactivation of Kv1.4 Potassium Channels by a Voltage-Dependent Oxidative Mechanism
J Pharmacol Exp Ther 2001 299: 227-237. [Abstract] [Full Text] [PDF]  

Munehiro Shiraishi, Kouichiro Minami, Yasuhito Uezono, Nobuyuki Yanagihara, and Akio Shigematsu

Inhibition by Tramadol of Muscarinic Receptor-Induced Responses in Cultured Adrenal Medullary Cells and in Xenopus laevis Oocytes Expressing Cloned M₁ Receptors
J Pharmacol Exp Ther 2001 299: 255-260. [Abstract] [Full Text] [PDF]  

D. M. Weiner, E. S. Burstein, N. Nash, G. E. Croston, E. A. Currier, K. E. Vanover, S. C. Harvey, E. Donohue, H. C. Hansen, C. M. Andersson, T. A. Spalding, D. F. C. Gibson, K. Krebs-Thomson, S. B. Powell, M. A. Geyer, U. Hacksell, and M. R. Brann

5-Hydroxytryptamine_2A Receptor Inverse Agonists as Antipsychotics
J Pharmacol Exp Ther 2001 299: 268-276. [Abstract] [Full Text] [PDF]  

Gregory G. Blakley, Larissa A. Pohorecky, and Daniel Benjamin

Bidirectional Changes in Ethanol Consumption in Rats with Site-Specific Antisense Down-Regulation of 5-Hydroxytryptamine_2A Receptors in Brain
J Pharmacol Exp Ther 2001 299: 277-289. [Abstract] [Full Text] [PDF]  

Bruno Bontempi, Kevin T. Whelan, Victoria B. Risbrough, Tadimeti S. Rao, Jerry J. Buccafusco, G. Kenneth Lloyd, and Frédérique Menzaghi

SIB-1553A, (±)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors with Putative Cognitive-Enhancing Properties: Effects on Working and Reference Memory Performances in Aged Rodents and Nonhuman Primates
J Pharmacol Exp Ther 2001 299: 297-306. [Abstract] [Full Text] [PDF]  

Thierry Canton, Georg Andrees Böhme, Alain Boireau, Françoise Bordier, Serge Mignani, Patrick Jimonet, Ghafoor Jahn, Mohammad Alavijeh, James Stygall, Simon Roberts, Clive Brealey, Marc Vuilhorgne, Marc-William Debono, Sylvain Le Guern, Michel Laville, Dominique Briet, Michel Roux, Jean-Marie Stutzmann, and Jeremy Pratt

RPR 119990, a Novel -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Antagonist: Synthesis, Pharmacological Properties, and Activity in an Animal Model of Amyotrophic Lateral Sclerosis
J Pharmacol Exp Ther 2001 299: 314-322. [Abstract] [Full Text] [PDF]  

Irina Fedorova, Akihiro Hashimoto, Robert A. Fecik, Michael P. Hedrick, Lumír O. Hanu, Dale L. Boger, Kenner C. Rice, and Anthony S. Basile

Behavioral Evidence for the Interaction of Oleamide with Multiple Neurotransmitter Systems
J Pharmacol Exp Ther 2001 299: 332-342. [Abstract] [Full Text] [PDF]  

Yingxian Xiao, Richard D. Smith, Frank S. Caruso, and Kenneth J. Kellar

Blockade of Rat 34 Nicotinic Receptor Function by Methadone, Its Metabolites, and Structural Analogs
J Pharmacol Exp Ther 2001 299: 366-371. [Abstract] [Full Text] [PDF]  

So Young Seo, Bong-Sik Yun, In-Ja Ryoo, Jun-Sub Choi, Choun-Ki Joo, Su-Youne Chang, Jun-Mo Chung, Seikwan Oh, Byoung Joo Gwag, and Ick Dong Yoo

Complestatin Is a Noncompetitive Peptide Antagonist of N-Methyl-D-aspartate and -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/Kainate Receptors: Secure Blockade of Ischemic Neuronal Death
J Pharmacol Exp Ther 2001 299: 377-384. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Actions of pyrethroid insecticides on sodium currents, action potentials, and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts"
J Pharmacol Exp Ther 2001 299: 399. [Full Text] [PDF]  

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