PERSPECTIVES IN PHARMACOLOGY:

Ronald J. Tallarida

Drug Synergism: Its Detection and Applications
J Pharmacol Exp Ther 2001 298: 865-872. [Abstract] [Full Text] [PDF]  

Sunit Talapatra and Craig B. Thompson

Growth Factor Signaling in Cell Survival: Implications for Cancer Treatment
J Pharmacol Exp Ther 2001 298: 873-878. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Timothy W. Hepburn, Timothy K. Hart, Vicki L. Horton, Teresa S. Sellers, LeeAnn P. Tobia, James J. Urbanski, Wei Shi, and Charles B. Davis

Pharmacokinetics and Tissue Distribution of SB-251353, a Novel Human CXC Chemokine, after Intravenous Administration to Mice
J Pharmacol Exp Ther 2001 298: 886-893. [Abstract] [Full Text] [PDF]  

S. A. Thomas, A. Bye, and M. B. Segal

Transport Characteristics of the Anti-human Immunodeficiency Virus Nucleoside Analog, Abacavir, into Brain and Cerebrospinal Fluid
J Pharmacol Exp Ther 2001 298: 947-953. [Abstract] [Full Text] [PDF]  

Naomi Morita, Hiroyuki Kusuhara, Takashi Sekine, Hitoshi Endou, and Yuichi Sugiyama

Functional Characterization of Rat Organic Anion Transporter 2 in LLC-PK1 Cells
J Pharmacol Exp Ther 2001 298: 1179-1184. [Abstract] [Full Text] [PDF]  

Karen O. Hamilton, Elizabeth Topp, Irwan Makagiansar, Teruna Siahaan, Mehran Yazdanian, and Kenneth L. Audus

Multidrug Resistance-Associated Protein-1 Functional Activity in Calu-3 Cells
J Pharmacol Exp Ther 2001 298: 1199-1205. [Abstract] [Full Text] [PDF]  

Rajesh Krishna, Murray S. Webb, Ginette St. Onge, and Lawrence D. Mayer

Liposomal and Nonliposomal Drug Pharmacokinetics after Administration of Liposome-Encapsulated Vincristine and Their Contribution to Drug Tissue Distribution Properties
J Pharmacol Exp Ther 2001 298: 1206-1212. [Abstract] [Full Text] [PDF]  

Seong Hoon Jang, M. Guillaume Wientjes, and Jessie L.-S. Au

Kinetics of P-Glycoprotein-Mediated Efflux of Paclitaxel
J Pharmacol Exp Ther 2001 298: 1236-1242. [Abstract] [Full Text] [PDF]  

Bill J. Smith, Angela C. Doran, Stafford McLean, F. David Tingley, III, Brian T. O'Neill, and Shama M. Kajiji

P-Glycoprotein Efflux at the Blood-Brain Barrier Mediates Differences in Brain Disposition and Pharmacodynamics between Two Structurally Related Neurokinin-1 Receptor Antagonists
J Pharmacol Exp Ther 2001 298: 1252-1259. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Xin-Liang Ma, Feng Gao, Allen H. Nelson, Bernard L. Lopez, Theodore A. Christopher, Tian-Li Yue, and Frank C. Barone

Oxidative Inactivation of Nitric Oxide and Endothelial Dysfunction in Stroke-Prone Spontaneous Hypertensive Rats
J Pharmacol Exp Ther 2001 298: 879-885. [Abstract] [Full Text] [PDF]  

Richard White, Fiona E. Bottrill, Derrick Siau, and C. Robin Hiley

Protein Kinase A-Dependent and -Independent Effects of Isoproterenol in Rat Isolated Mesenteric Artery: Interactions with Levcromakalim
J Pharmacol Exp Ther 2001 298: 917-924. [Abstract] [Full Text] [PDF]  

Wei Xiong, Heidi M. Moore, Susan E. Howlett, and Gregory R. Ferrier

In Contrast to Forskolin and 3-Isobutyl-1-methylxanthine, Amrinone Stimulates the Cardiac Voltage-Sensitive Release Mechanism without Increasing Calcium-Induced Calcium Release
J Pharmacol Exp Ther 2001 298: 954-963. [Abstract] [Full Text] [PDF]  

J. A. Schriefer, E. P. Broudy, and A. H. Hassen

Inhibitors of Bradykinin-Inactivating Enzymes Decrease Myocardial Ischemia/Reperfusion Injury following 3 and 7 Days of Reperfusion
J Pharmacol Exp Ther 2001 298: 970-975. [Abstract] [Full Text] [PDF]  

Yutaka Oda and Evan D. Kharasch

Metabolism of Methadone and levo--Acetylmethadol (LAAM) by Human Intestinal Cytochrome P450 3A4 (CYP3A4): Potential Contribution of Intestinal Metabolism to Presystemic Clearance and Bioactivation
J Pharmacol Exp Ther 2001 298: 1021-1032. [Abstract] [Full Text] [PDF]  

Reiko Takahashi, Yasuhisa Shimazaki, and Masao Endoh

Decrease in Ca²⁺-Sensitizing Effect of UD-CG 212 Cl, a Metabolite of Pimobendan, under Acidotic Condition in Canine Ventricular Myocardium
J Pharmacol Exp Ther 2001 298: 1060-1066. [Abstract] [Full Text] [PDF]  

Loïc Perchenet, Laurence Hilfiger, Jacques Mizrahi, and Odile Clément-Chomienne

Effects of Anorexinogen Agents on Cloned Voltage-Gated K⁺ Channel hKv1.5
J Pharmacol Exp Ther 2001 298: 1108-1119. [Abstract] [Full Text] [PDF]  

Kotaro Suehiro, Juichiro Shimizu, Geng-Hua Yi, Anguo Gu, Jie Wang, Gad Keren, and Daniel Burkhoff

Selective Renal Vasodilation and Active Renal Artery Perfusion Improve Renal Function in Dogs with Acute Heart Failure
J Pharmacol Exp Ther 2001 298: 1154-1160. [Abstract] [Full Text] [PDF]  

Naoya Satoh, Taku Sato, Mayumi Shimada, Kumi Yamada, and Yoshimi Kitada

Lusitropic Effect of MCC-135 Is Associated with Improvement of Sarcoplasmic Reticulum Function in Ventricular Muscles of Rats with Diabetic Cardiomyopathy
J Pharmacol Exp Ther 2001 298: 1161-1166. [Abstract] [Full Text] [PDF]  

Jin-Chen Yu, Nathalie A. Lokker, Stanley Hollenbach, Mutiah Apatira, Jason Li, Andreas Betz, David Sedlock, Shoji Oda, Yuji Nomoto, Kenji Matsuno, Shin-ichi Ide, Eiji Tsukuda, and Neill A. Giese

Efficacy of the Novel Selective Platelet-Derived Growth Factor Receptor Antagonist CT52923 on Cellular Proliferation, Migration, and Suppression of Neointima following Vascular Injury
J Pharmacol Exp Ther 2001 298: 1172-1178. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Michele T. Yip-Schneider, Christopher J. Sweeney, Sin-Ho Jung, Pamela L. Crowell, and Mark S. Marshall

Cell Cycle Effects of Nonsteroidal Anti-Inflammatory Drugs and Enhanced Growth Inhibition in Combination with Gemcitabine in Pancreatic Carcinoma Cells
J Pharmacol Exp Ther 2001 298: 976-985. [Abstract] [Full Text] [PDF]  

Erik G. A. Harks, Albert D. G. de Roos, Peter H. J. Peters, Laura H. de Haan, Abraham Brouwer, Dirk L. Ypey, Everardus J. J. van Zoelen, and Alexander P. R. Theuvenet

Fenamates: A Novel Class of Reversible Gap Junction Blockers
J Pharmacol Exp Ther 2001 298: 1033-1041. [Abstract] [Full Text] [PDF]  

Domenico Tricarico, Mariagrazia Barbieri, and Diana Conte Camerino

Voltage-Dependent Antagonist/Agonist Actions of Taurine on Ca²⁺-Activated Potassium Channels of Rat Skeletal Muscle Fibers
J Pharmacol Exp Ther 2001 298: 1167-1171. [Abstract] [Full Text] [PDF]  

Huiping Zhou, Fengxiang Yan, and Hsin-Hsiung Tai

Phosphorylation and Desensitization of the Human Thromboxane Receptor- by G Protein-Coupled Receptor Kinases
J Pharmacol Exp Ther 2001 298: 1243-1251. [Abstract] [Full Text] [PDF]  

Arthur Christopoulos, Marianne K. O. Grant, Negar Ayoubzadeh, Ok Nyu Kim, Per Sauerberg, Lone Jeppesen, and Esam E. El-Fakahany

Synthesis and Pharmacological Evaluation of Dimeric Muscarinic Acetylcholine Receptor Agonists
J Pharmacol Exp Ther 2001 298: 1260-1268. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Tobias Zellweger, Hideaki Miyake, Scott Cooper, Kim Chi, Boyd S. Conklin, Brett P. Monia, and Martin E. Gleave

Antitumor Activity of Antisense Clusterin Oligonucleotides Is Improved in Vitro and in Vivo by Incorporation of 2'-O-(2-Methoxy)Ethyl Chemistry
J Pharmacol Exp Ther 2001 298: 934-940. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Yoshiyuki Yabe, Naoki Kobayashi, Tsuyoshi Nishihashi, Rei Takahashi, Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida

Prevention of Neutrophil-Mediated Hepatic Ischemia/Reperfusion Injury by Superoxide Dismutase and Catalase Derivatives
J Pharmacol Exp Ther 2001 298: 894-899. [Abstract] [Full Text] [PDF]  

Richard M. Edwards and David P. Brooks

Dopamine Inhibits Vasopressin Action in the Rat Inner Medullary Collecting Duct via ₂-Adrenoceptors
J Pharmacol Exp Ther 2001 298: 1001-1006. [Abstract] [Full Text] [PDF]  

Varanuj Chatsudthipong and Promsuk Jutabha

Effect of Steviol on para-Aminohippurate Transport by Isolated Perfused Rabbit Renal Proximal Tubule
J Pharmacol Exp Ther 2001 298: 1120-1127. [Abstract] [Full Text] [PDF]  

Esko Kankuri, Kirsi Vaali, Richard G. Knowles, Mari Lähde, Riitta Korpela, Heikki Vapaatalo, and Eeva Moilanen

Suppression of Acute Experimental Colitis by a Highly Selective Inducible Nitric-Oxide Synthase Inhibitor, N-[3-(Aminomethyl)benzyl]acetamidine
J Pharmacol Exp Ther 2001 298: 1128-1132. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

James G. Conway, Robert C. Andrews, Beth Beaudet, D. Mark Bickett, Virginia Boncek, Thomas A. Brodie, Richard L. Clark, R. Christian Crumrine, Michael A. Leenitzer, Darryl L. McDougald, Bajin Han, Kevin Hedeen, Peiyuan Lin, Marcos Milla, Marcia Moss, Heather Pink, Michael H. Rabinowitz, Timothy Tippin, Phillip W. Scates, Jeffrey Selph, Stephen A. Stimpson, Janet Warner, and J. David Becherer

Inhibition of Tumor Necrosis Factor- (TNF-) Production and Arthritis in the Rat by GW3333, a Dual Inhibitor of TNF--Converting Enzyme and Matrix Metalloproteinases
J Pharmacol Exp Ther 2001 298: 900-908. [Abstract] [Full Text] [PDF]  

Eva-Maria Boneberg and Thomas Hartung

Mistletoe Lectin-1 Increases Tumor Necrosis Factor- Release in Lipopolysaccharide-Stimulated Whole Blood via Inhibition of Interleukin-10 Production
J Pharmacol Exp Ther 2001 298: 996-1000. [Abstract] [Full Text] [PDF]  

Motonori Aoki, Masahiro Fukunaga, Tohru Sugimoto, Yasuno Hirano, Miki Kobayashi, Kazuo Honda, and Toshimitsu Yamada

Studies on Mechanisms of Low Emetogenicity of YM976, a Novel Phosphodiesterase Type 4 Inhibitor
J Pharmacol Exp Ther 2001 298: 1142-1149. [Abstract] [Full Text] [PDF]  

Barbara Mui, Sameersingh G. Raney, Sean C. Semple, and Michael J. Hope

Immune Stimulation by a CpG-Containing Oligodeoxynucleotide Is Enhanced When Encapsulated and Delivered in Lipid Particles
J Pharmacol Exp Ther 2001 298: 1185-1192. [Abstract] [Full Text] [PDF]  

Claire Gavériaux-Ruff, Dominique Filliol, Frédéric Simonin, Hans W. D. Matthes, and Brigitte L. Kieffer

Immunosuppression by -Opioid Antagonist Naltrindole: - and Triple µ//-Opioid Receptor Knockout Mice Reveal a Nonopioid Activity
J Pharmacol Exp Ther 2001 298: 1193-1198. [Abstract] [Full Text] [PDF]  

Joost P. H. Drenth, Alieke G. Vonk, Anna Simon, Richard Powell, and Jos W. M. van der Meer

Limited Efficacy of Thalidomide in the Treatment of Febrile Attacks of the Hyper-IgD and Periodic Fever Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
J Pharmacol Exp Ther 2001 298: 1221-1226. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

J.-Q. Kong, J. Meng, P. S. Biser, W. W. Fleming, and D. A. Taylor

Cellular Depolarization of Neurons in the Locus Ceruleus Region of the Guinea Pig Associated with the Development of Tolerance to Opioids
J Pharmacol Exp Ther 2001 298: 909-916. [Abstract] [Full Text] [PDF]  

Gail D. Zeevalk, Laura P. Bernard, Lawrence Manzino, and Patricia K. Sonsalla

Differential Sensitivity of Mesencephalic Neurons to Inhibition of Phosphatase 2A
J Pharmacol Exp Ther 2001 298: 925-933. [Abstract] [Full Text] [PDF]  

Karen R. M. Russell and David E. Potter

Biphasic Alterations of cAMP Levels and Inhibition of Norepinephrine Release in Iris-Ciliary Body by Bremazocine
J Pharmacol Exp Ther 2001 298: 941-946. [Abstract] [Full Text] [PDF]  

Jarupa Viyoch, Shigehiro Ohdo, Eiji Yukawa, and Shun Higuchi

Dosing Time-Dependent Tolerance of Catalepsy by Repetitive Administration of Haloperidol in Mice
J Pharmacol Exp Ther 2001 298: 964-969. [Abstract] [Full Text] [PDF]  

Ren-Qi Huang, Cathy L. Bell-Horner, Mohammed I. Dibas, Douglas F. Covey, John A. Drewe, and Glenn H. Dillon

Pentylenetetrazole-Induced Inhibition of Recombinant -Aminobutyric Acid Type A (GABA_A) Receptors: Mechanism and Site of Action
J Pharmacol Exp Ther 2001 298: 986-995. [Abstract] [Full Text] [PDF]  

A. H. Lichtman, S. M. Sheikh, H. H. Loh, and B. R. Martin

Opioid and Cannabinoid Modulation of Precipitated Withdrawal in ⁹-Tetrahydrocannabinol and Morphine-Dependent Mice
J Pharmacol Exp Ther 2001 298: 1007-1014. [Abstract] [Full Text] [PDF]  

Paulette A. Zaki, Duane E. Keith, Jr., James B. Thomas, F. I. Carroll, and Christopher J. Evans

Agonist-, Antagonist-, and Inverse Agonist-Regulated Trafficking of the -Opioid Receptor Correlates with, but Does Not Require, G Protein Activation
J Pharmacol Exp Ther 2001 298: 1015-1020. [Abstract] [Full Text] [PDF]  

David Weinshenker, Patricia Szot, Nicole S. Miller, and Richard D. Palmiter

₁ and ₂ Adrenoreceptor Agonists Inhibit Pentylenetetrazole-Induced Seizures in Mice Lacking Norepinephrine
J Pharmacol Exp Ther 2001 298: 1042-1048. [Abstract] [Full Text] [PDF]  

Eduardo R. Butelman, M. C. Holden Ko, John R. Traynor, Jeffrey A. Vivian, Mary-Jeanne Kreek, and James H. Woods

GR89,696: A Potent -Opioid Agonist with Subtype Selectivity in Rhesus Monkeys
J Pharmacol Exp Ther 2001 298: 1049-1059. [Abstract] [Full Text] [PDF]  

Deborah A. Knobelman, René Hen, and Irwin Lucki

Genetic Regulation of Extracellular Serotonin by 5-Hydroxytryptamine_1A and 5-Hydroxytryptamine_1B Autoreceptors in Different Brain Regions of the Mouse
J Pharmacol Exp Ther 2001 298: 1083-1091. [Abstract] [Full Text] [PDF]  

Deborah A. Knobelman, René Hen, Julie A. Blendy, and Irwin Lucki

Regional Patterns of Compensation following Genetic Deletion of Either 5-Hydroxytryptamine_1A or 5-Hydroxytryptamine_1B Receptor in the Mouse
J Pharmacol Exp Ther 2001 298: 1092-1100. [Abstract] [Full Text] [PDF]  

Arthur J. Mayorga, Ashutosh Dalvi, Michelle E. Page, Sarah Zimov-Levinson, René Hen, and Irwin Lucki

Antidepressant-Like Behavioral Effects in 5-Hydroxytryptamine_1A and 5-Hydroxytryptamine_1B Receptor Mutant Mice
J Pharmacol Exp Ther 2001 298: 1101-1107. [Abstract] [Full Text] [PDF]  

Bin Liu, Liya Qin, San-Nan Yang, Belinda C. Wilson, Yuxin Liu, and Jau-Shyong Hong

Femtomolar Concentrations of Dynorphins Protect Rat Mesencephalic Dopaminergic Neurons against Inflammatory Damage
J Pharmacol Exp Ther 2001 298: 1133-1141. [Abstract] [Full Text] [PDF]  

Jeffrey M. Brown, Glen R. Hanson, and Annette E. Fleckenstein

Cocaine-Induced Increases in Vesicular Dopamine Uptake: Role of Dopamine Receptors
J Pharmacol Exp Ther 2001 298: 1150-1153. [Abstract] [Full Text] [PDF]  

Daya S. Gupta, Andrew B. Kelson, Willma E. Polgar, Lawrence Toll, Maria Szücs, and Alan R. Gintzler

Ovarian Sex Steroid-Dependent Plasticity of Nociceptin/Orphanin FQ and Opioid Modulation of Spinal Dynorphin Release
J Pharmacol Exp Ther 2001 298: 1213-1220. [Abstract] [Full Text] [PDF]  

Lance R. McMahon, Lisa R. Gerak, and Charles P. France

Potency of Positive -Aminobutyric Acid_A Modulators to Substitute for a Midazolam Discriminative Stimulus in Untreated Monkeys Does Not Predict Potency to Attenuate a Flumazenil Discriminative Stimulus in Diazepam-Treated Monkeys
J Pharmacol Exp Ther 2001 298: 1227-1235. [Abstract] [Full Text] [PDF]  

Alexandre Urani, François J. Roman, Vân-Ly Phan, Tsung-Ping Su, and Tangui Maurice

The Antidepressant-Like Effect Induced by ₁-Receptor Agonists and Neuroactive Steroids in Mice Submitted to the Forced Swimming Test
J Pharmacol Exp Ther 2001 298: 1269-1279. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

C. Ian Spencer, Kathryn H. Yuill, John J. Borg, Jules C. Hancox, and Roland Z. Kozlowski

Actions of Pyrethroid Insecticides on Sodium Currents, Action Potentials, and Contractile Rhythm in Isolated Mammalian Ventricular Myocytes and Perfused Hearts
J Pharmacol Exp Ther 2001 298: 1067-1082. [Abstract] [Full Text] [PDF]  

M. W. Bolt, J. W. Card, W. J. Racz, J. F. Brien, and T. E. Massey

Disruption of Mitochondrial Function and Cellular ATP Levels by Amiodarone and N-Desethylamiodarone in Initiation of Amiodarone-Induced Pulmonary Cytotoxicity
J Pharmacol Exp Ther 2001 298: 1280-1289. [Abstract] [Full Text] [PDF]  

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