PERSPECTIVES IN PHARMACOLOGY:

Linda P. Dwoskin and Peter A. Crooks

Competitive Neuronal Nicotinic Receptor Antagonists: A New Direction for Drug Discovery
J Pharmacol Exp Ther 2001 298: 395-402. [Abstract] [Full Text] [PDF]  

Michael T. Piascik and Dianne M. Perez

₁-Adrenergic Receptors: New Insights and Directions
J Pharmacol Exp Ther 2001 298: 403-410. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Anthony J. Lee, Joseph W. Kosh, Allan H. Conney, and Bao Ting Zhu

Characterization of the NADPH-Dependent Metabolism of 17-Estradiol to Multiple Metabolites by Human Liver Microsomes and Selectively Expressed Human Cytochrome P450 3A4 and 3A5
J Pharmacol Exp Ther 2001 298: 420-432. [Abstract] [Full Text] [PDF]  

Zeruesenay Desta, Nadia Soukhova, Alan M Morocho, and David A Flockhart

Stereoselective Metabolism of Cisapride and Enantiomer-Enantiomer Interaction in Human Cytochrome P450 Enzymes: Major Role of CYP3A
J Pharmacol Exp Ther 2001 298: 508-520. [Abstract] [Full Text] [PDF]  

Peter Laverman, Myrra G. Carstens, Otto C. Boerman, Els Th. M. Dams, Wim J. G. Oyen, Nico van Rooijen, Frans H. M. Corstens, and Gert Storm

Factors Affecting the Accelerated Blood Clearance of Polyethylene Glycol-Liposomes upon Repeated Injection
J Pharmacol Exp Ther 2001 298: 607-612. [Abstract] [Full Text] [PDF]  

Megumi Irie, Tomohiro Terada, Kyoko Sawada, Hideyuki Saito, and Ken-Ichi Inui

Recognition and Transport Characteristics of Nonpeptidic Compounds by Basolateral Peptide Transporter in Caco-2 Cells
J Pharmacol Exp Ther 2001 298: 711-717. [Abstract] [Full Text] [PDF]  

Yoshiki Suginoshita, Yasuhiko Tabata, Fuminori Moriyasu, Yoshito Ikada, and Tsutomu Chiba

Liver Targeting of Interferon- with a Liver-Affinity Polysaccharide Based on Metal Coordination in Mice
J Pharmacol Exp Ther 2001 298: 805-811. [Abstract] [Full Text] [PDF]  

S. Chapel, P. Veng-Pedersen, R. J. Hohl, R. L. Schmidt, E. M. McGuire, and J. A. Widness

Changes in Erythropoietin Pharmacokinetics following Busulfan-Induced Bone Marrow Ablation in Sheep: Evidence for Bone Marrow as a Major Erythropoietin Elimination Pathway
J Pharmacol Exp Ther 2001 298: 820-824. [Abstract] [Full Text] [PDF]  

Ken A. Witt, Jason D. Huber, Richard D. Egleton, Michael J. Roberts, Michael D. Bentley, Lihong Guo, Hongbing Wei, Henry I. Yamamura, and Thomas P. Davis

Pharmacodynamic and Pharmacokinetic Characterization of Poly(Ethylene glycol) Conjugation to Met-Enkephalin Analog [D-Pen²,D-Pen⁵]-enkephalin (DPDPE)
J Pharmacol Exp Ther 2001 298: 848-856. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

James E. Faber, Nengyu Yang, and Xiaohua Xin

Expression of -Adrenoceptor Subtypes by Smooth Muscle Cells and Adventitial Fibroblasts in Rat Aorta and in Cell Culture
J Pharmacol Exp Ther 2001 298: 441-452. [Abstract] [Full Text] [PDF]  

Guang-Wu Wang, Jon B. Klein, and Y. James Kang

Metallothionein Inhibits Doxorubicin-Induced Mitochondrial Cytochrome c Release and Caspase-3 Activation in Cardiomyocytes
J Pharmacol Exp Ther 2001 298: 461-468. [Abstract] [Full Text] [PDF]  

Ling Chen, Xiaohong Tracey Gan, James V. Haist, Qingping Feng, Xiangru Lu, Subrata Chakrabarti, and Morris Karmazyn

Attenuation of Compensatory Right Ventricular Hypertrophy and Heart Failure following Monocrotaline-Induced Pulmonary Vascular Injury by the Na⁺-H⁺ Exchange Inhibitor Cariporide
J Pharmacol Exp Ther 2001 298: 469-476. [Abstract] [Full Text] [PDF]  

Brigitte M. Stavrou, Desmond J. Sheridan, and Nicholas A. Flores

Contribution of Nitric Oxide and Prostanoids to the Cardiac Electrophysiological and Coronary Vasomotor Effects of Diadenosine Polyphosphates
J Pharmacol Exp Ther 2001 298: 531-538. [Abstract] [Full Text] [PDF]  

You-Tang Shen, Tamara J. Pittman, Pamela S. Buie, David L. Bolduc, Stefanie A. Kane, Kenneth S. Koblan, Robert J. Gould, and Joseph J. Lynch, Jr.

Functional Role of -Calcitonin Gene-Related Peptide in the Regulation of the Cardiovascular System
J Pharmacol Exp Ther 2001 298: 551-558. [Abstract] [Full Text] [PDF]  

M. J. Hernandez-Benito, R. Macianskiene, K. R. Sipido, W. Flameng, and K. Mubagwa

Suppression of Transient Outward Potassium Currents in Mouse Ventricular Myocytes by Imidazole Antimycotics and by Glybenclamide
J Pharmacol Exp Ther 2001 298: 598-606. [Abstract] [Full Text] [PDF]  

Toshiteru Ishitani, Yuichi Hattori, Fumika Sakuraya, Hisao Onozuka, Takao Makino, Naoyuki Matsuda, Satoshi Gando, and Osamu Kemmotsu

Effects of Ca²⁺ Sensitizers on Contraction, [Ca²⁺]_i Transient and Myofilament Ca²⁺ Sensitivity in Diabetic Rat Myocardium: Potential Usefulness as Inotropic Agents
J Pharmacol Exp Ther 2001 298: 613-622. [Abstract] [Full Text] [PDF]  

Jean-François Théorêt, Jean-Guy Bienvenu, Anjali Kumar, and Yahye Merhi

P-Selectin Antagonism with Recombinant P-Selectin Glycoprotein Ligand-1 (rPSGL-Ig) Inhibits Circulating Activated Platelet Binding to Neutrophils Induced by Damaged Arterial Surfaces
J Pharmacol Exp Ther 2001 298: 658-664. [Abstract] [Full Text] [PDF]  

N. D. Vaziri, Y. Ding, and Z. Ni

Compensatory Up-Regulation of Nitric-Oxide Synthase Isoforms in Lead-Induced Hypertension; Reversal by a Superoxide Dismutase-Mimetic Drug
J Pharmacol Exp Ther 2001 298: 679-685. [Abstract] [Full Text] [PDF]  

Patrícia I. B. Ceron, Daniela C. Cremonez, Lusiane M. Bendhack, and Antonio C. Tedesco

The Relaxation Induced by S-Nitroso-Glutathione and S-Nitroso-N-Acetylcysteine in Rat Aorta Is Not Related to Nitric Oxide Production
J Pharmacol Exp Ther 2001 298: 686-694. [Abstract] [Full Text] [PDF]  

Mircea Iftinca, Gareth J. Waldron, Christopher R. Triggle, and William C. Cole

State-Dependent Block of Rabbit Vascular Smooth Muscle Delayed Rectifier and Kv1.5 Channels by Inhibitors of Cytochrome P450-Dependent Enzymes
J Pharmacol Exp Ther 2001 298: 718-728. [Abstract] [Full Text] [PDF]  

Kiyoshi Tadano, Jun Suzuki, Kayoko Hanada, Mizuki Nakao, Rumi Nakao, Sayuri Uehara, Hisashi Ohta, Takashi Miyauchi, and Masaru Nishikibe

Pathophysiological Roles of Endogenous Endothelin-1 in Dogs with Chronic Heart Failure Produced by Rapid Right Ventricular Pacing
J Pharmacol Exp Ther 2001 298: 729-736. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Justyn M. Thomas, Grant C. Churchill, Sandip Patel, and Antony Galione

Distinct Pharmacology of 2-Hydroxycarbazole-Induced Ca²⁺ Release in the Sea Urchin Egg
J Pharmacol Exp Ther 2001 298: 644-650. [Abstract] [Full Text] [PDF]  

John Hines, Jennifer N. Heerding, Steven J. Fluharty, and Daniel K. Yee

Identification of Angiotensin II Type 2 (AT₂) Receptor Domains Mediating High-Affinity CGP 42112A Binding and Receptor Activation
J Pharmacol Exp Ther 2001 298: 665-673. [Abstract] [Full Text] [PDF]  

Peter J. Syapin, Julius D. Militante, Daniel K. Garrett, and Li Ren

Cytokine-Induced iNOS Expression in C6 Glial Cells: Transcriptional Inhibition by Ethanol
J Pharmacol Exp Ther 2001 298: 744-752. [Abstract] [Full Text] [PDF]  

Eugenia H. Hsu, Anthony C. Lochan, and Daniel S. Cowen

Activation of Akt1 by Human 5-Hydroxytryptamine (Serotonin)_1B Receptors Is Sensitive to Inhibitors of MEK
J Pharmacol Exp Ther 2001 298: 825-832. [Abstract] [Full Text] [PDF]  

Roland Seifert

Monovalent Anions Differentially Modulate Coupling of the ₂-Adrenoceptor to G_s Splice Variants
J Pharmacol Exp Ther 2001 298: 840-847. [Abstract] [Full Text] [PDF]  

Jian-Bing Shen and Achilles J. Pappano

Carbachol Inhibits the L-Type Ca²⁺ Current Augmented by 1,2-bis(2-Aminophenoxy)ethane-N,N,N',N'-Tetraacetic Acid in Guinea Pig Ventricular Myocytes: Calcium-Sensitivity Hypothesis for Muscarinic Inhibition
J Pharmacol Exp Ther 2001 298: 857-864. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Randal W. Berg, Melanie Werner, Peter J. Ferguson, Carl Postenka, Mark Vincent, D. James Koropatnick, and Elke Behrend

Tumor Growth Inhibition in Vivo and G₂/M Cell Cycle Arrest Induced by Antisense Oligodeoxynucleotide Targeting Thymidylate Synthase
J Pharmacol Exp Ther 2001 298: 477-484. [Abstract] [Full Text] [PDF]  

Betsy J. Barnes, Robert A. Izydore, Ann E. Eakin, and Iris H. Hall

Induction of Tmolt₄ Leukemia Cell Death by 3,3-Disubstituted-6,6-pentamethylene-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: Specificity for Type II Inosine 5'-Monophosphate Dehydrogenase
J Pharmacol Exp Ther 2001 298: 790-796. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Steven M. Grassl

Ethanolamine Transport in Human Placental Brush-Border Membrane Vesicles
J Pharmacol Exp Ther 2001 298: 695-702. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Makoto Itoh, Masanori Takaoka, Akihide Shibata, Mamoru Ohkita, and Yasuo Matsumura

Preventive Effect of Lactacystin, a Selective Proteasome Inhibitor, on Ischemic Acute Renal Failure in Rats
J Pharmacol Exp Ther 2001 298: 501-507. [Abstract] [Full Text] [PDF]  

Shiho Okano, Hideaki Nagaya, Yoshinori Ikeura, Hideaki Natsugari, and Nobuhiro Inatomi

Effects of TAK-637, a Novel Neurokinin-1 Receptor Antagonist, on Colonic Function in Vivo
J Pharmacol Exp Ther 2001 298: 559-564. [Abstract] [Full Text] [PDF]  

Vernon T. Cannon, Rudolfs K. Zalups, and Delon W. Barfuss

Amino Acid Transporters Involved in Luminal Transport of Mercuric Conjugates of Cysteine in Rabbit Proximal Tubule
J Pharmacol Exp Ther 2001 298: 780-789. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Akinori Arimura, Kiyoshi Yasui, Junji Kishino, Fujio Asanuma, Hiroshi Hasegawa, Shinji Kakudo, Mitsuaki Ohtani, and Hitoshi Arita

Prevention of Allergic Inflammation by a Novel Prostaglandin Receptor Antagonist, S-5751
J Pharmacol Exp Ther 2001 298: 411-419. [Abstract] [Full Text] [PDF]  

Hongyan Zhong, Janci L. Chunn, Jonathan B. Volmer, John R. Fozard, and Michael R. Blackburn

Adenosine-Mediated Mast Cell Degranulation in Adenosine Deaminase-Deficient Mice
J Pharmacol Exp Ther 2001 298: 433-440. [Abstract] [Full Text] [PDF]  

Atsushi Masamune, Masayoshi Yoshida, Yoshitaka Sakai, and Tooru Shimosegawa

Rebamipide Inhibits Ceramide-Induced Interleukin-8 Production in Kato III Human Gastric Cancer Cells
J Pharmacol Exp Ther 2001 298: 485-492. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Rebecca A. Wright, M. Brian Arnold, William J. Wheeler, Paul L. Ornstein, and Darryle D. Schoepp

[³H]LY341495 Binding to Group II Metabotropic Glutamate Receptors in Rat Brain
J Pharmacol Exp Ther 2001 298: 453-460. [Abstract] [Full Text] [PDF]  

Lih-Chu Chiou and Cheng-Hung How

ATP-Sensitive K⁺ Channels and Cellular Actions of Morphine in Periaqueductal Gray Slices of Neonatal and Adult Rats
J Pharmacol Exp Ther 2001 298: 493-500. [Abstract] [Full Text] [PDF]  

Yuri A. Blednov, M. Stoffel, S. R. Chang, and R. Adron Harris

Potassium Channels as Targets for Ethanol: Studies of G-Protein-Coupled Inwardly Rectifying Potassium Channel 2 (GIRK2) Null Mutant Mice
J Pharmacol Exp Ther 2001 298: 521-530. [Abstract] [Full Text] [PDF]  

Esa Meririnne, Aino Kankaanpää, and Timo Seppälä

Rewarding Properties of Methylphenidate: Sensitization by Prior Exposure to the Drug and Effects of Dopamine D1- and D2-Receptor Antagonists
J Pharmacol Exp Ther 2001 298: 539-550. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Alain Gobert, Françoise Lejeune, Adrian Newman-Tancredi, Jean-Michel Rivet, Agnès Auclair, and Jean-Louis Peglion

S33005, a Novel Ligand at Both Serotonin and Norepinephrine Transporters: I. Receptor Binding, Electrophysiological, and Neurochemical Profile in Comparison with Venlafaxine, Reboxetine, Citalopram, and Clomipramine
J Pharmacol Exp Ther 2001 298: 565-580. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Anne Dekeyne, Mariusz Papp, Christophe Drieu La Rochelle, Cliona MacSweeny, Jean-Louis Peglion, and Mauricette Brocco

S33005, a Novel Ligand at Both Serotonin and Norepinephrine Transporters: II. Behavioral Profile in Comparison with Venlafaxine, Reboxetine, Citalopram, and Clomipramine
J Pharmacol Exp Ther 2001 298: 581-591. [Abstract] [Full Text] [PDF]  

Masahiro Ohsawa, Hirokazu Mizoguchi, Minoru Narita, Hiroshi Nagase, John P. Kampine, and Leon F. Tseng

Differential Antinociception Induced by Spinally Administered Endomorphin-1 and Endomorphin-2 in the Mouse
J Pharmacol Exp Ther 2001 298: 592-597. [Abstract] [Full Text] [PDF]  

Latchezar D. Todorov, Rory Clerkin, Svetlana T. Mihaylova-Todorova, Mohammad A. Khoyi, and David P. Westfall

₂-Adrenoceptor-Mediated Prejunctional Facilitation and Postjunctional Inhibition of Sympathetic Neuroeffector Transmission in the Guinea Pig Vas Deferens
J Pharmacol Exp Ther 2001 298: 623-633. [Abstract] [Full Text] [PDF]  

Aaron Janowsky, Clifford Mah, Robert A. Johnson, Christopher L. Cunningham, Tamara J. Phillips, John C. Crabbe, Amy J. Eshleman, and John K. Belknap

Mapping Genes That Regulate Density of Dopamine Transporters and Correlated Behaviors in Recombinant Inbred Mice
J Pharmacol Exp Ther 2001 298: 634-643. [Abstract] [Full Text] [PDF]  

John F. Cryan, Ashutosh Dalvi, Sung-Ha Jin, Bradford R. Hirsch, Irwin Lucki, and Steven A. Thomas

Use of Dopamine--hydroxylase-Deficient Mice to Determine the Role of Norepinephrine in the Mechanism of Action of Antidepressant Drugs
J Pharmacol Exp Ther 2001 298: 651-657. [Abstract] [Full Text] [PDF]  

Dennis Paul, Dongdong Yao, Peimin Zhu, Lerna D. Minor, and Meredith Mason Garcia

5-Hydroxytryptamine₃ (5-HT₃) Receptors Mediate Spinal 5-HT Antinociception: An Antisense Approach
J Pharmacol Exp Ther 2001 298: 674-678. [Abstract] [Full Text] [PDF]  

Hiroshi Ueda, Makoto Inoue, Akira Yoshida, Kiyonobu Mizuno, Hideko Yamamoto, Junko Maruo, Kiyoshi Matsuno, and Shiro Mita

Metabotropic Neurosteroid/-Receptor Involved in Stimulation of Nociceptor Endings of Mice
J Pharmacol Exp Ther 2001 298: 703-710. [Abstract] [Full Text] [PDF]  

Guy Griebel, Ghislaine Perrault, Jacques Simiand, Caroline Cohen, Patrick Granger, Michel Decobert, Dominique Françon, Patrick Avenet, Henri Depoortere, Suon Tan, André Oblin, Hans Schoemaker, Yannick Evanno, Mireille Sevrin, Pascal George, and Bernard Scatton

SL651498: An Anxioselective Compound with Functional Selectivity for ₂- and ₃-Containing -Aminobutyric Acid_A (GABA_A) Receptors
J Pharmacol Exp Ther 2001 298: 753-768. [Abstract] [Full Text] [PDF]  

Alfred Heller, Nancy Bubula, Robert Lew, Barbara Heller, and Lisa Won

Gender-Dependent Enhanced Adult Neurotoxic Response to Methamphetamine following Fetal Exposure to the Drug
J Pharmacol Exp Ther 2001 298: 769-779. [Abstract] [Full Text] [PDF]  

Susan E. Robinson and Melisa J. Wallace

Effect of Perinatal Buprenorphine Exposure on Development in the Rat
J Pharmacol Exp Ther 2001 298: 797-804. [Abstract] [Full Text] [PDF]  

Frank M. Dautzenberg, Jürgen Wichmann, Jacqueline Higelin, Gabrielle Py-Lang, Claudia Kratzeisen, Pari Malherbe, Gavin J. Kilpatrick, and Francois Jenck

Pharmacological Characterization of the Novel Nonpeptide Orphanin FQ/Nociceptin Receptor Agonist Ro 64-6198: Rapid and Reversible Desensitization of the ORL1 Receptor in Vitro and Lack of Tolerance in Vivo
J Pharmacol Exp Ther 2001 298: 812-819. [Abstract] [Full Text] [PDF]  

Lina Yao, Kiyofumi Asai, Zhan Jiang, Akira Ishii, Peidong Fan, Adrienne S. Gordon, and Ivan Diamond

Dopamine D2 Receptor Inhibition of Adenylyl Cyclase Is Abolished by Acute Ethanol but Restored after Chronic Ethanol Exposure (Tolerance)
J Pharmacol Exp Ther 2001 298: 833-839. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Abdellah Mansouri, Christine Demeilliers, Sabine Amsellem, Dominique Pessayre, and Bernard Fromenty

Acute Ethanol Administration Oxidatively Damages and Depletes Mitochondrial DNA in Mouse Liver, Brain, Heart, and Skeletal Muscles: Protective Effects of Antioxidants
J Pharmacol Exp Ther 2001 298: 737-743. [Abstract] [Full Text] [PDF]  

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