PERSPECTIVES IN PHARMACOLOGY:

Leonard L. Howell and Kristin M. Wilcox

The Dopamine Transporter and Cocaine Medication Development: Drug Self-Administration in Nonhuman Primates
J Pharmacol Exp Ther 2001 298: 1-6. [Abstract] [Full Text] [PDF]  

Andrea Giuffrida, Massimiliano Beltramo, and Daniele Piomelli

Mechanisms of Endocannabinoid Inactivation: Biochemistry and Pharmacology
J Pharmacol Exp Ther 2001 298: 7-14. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Marcelo G. Luquita, Viviana A. Catania, Enrique J. Sánchez Pozzi, Luis M. Veggi, Tim Hoffman, José M. Pellegrino, Shin-ichi Ikushiro, Yoshikazu Emi, Takashi Iyanagi, Mary Vore, and Aldo D. Mottino

Molecular Basis of Perinatal Changes in UDP-Glucuronosyltransferase Activity in Maternal Rat Liver
J Pharmacol Exp Ther 2001 298: 49-56. [Abstract] [Full Text] [PDF]  

Hazel H. Szeto, Jerry L. Lovelace, Genevieve Fridland, Yi Soong, Joseph Fasolo, Dunli Wu, Dominic M. Desiderio, and Peter W. Schiller

In Vivo Pharmacokinetics of Selective µ-Opioid Peptide Agonists
J Pharmacol Exp Ther 2001 298: 57-61. [Abstract] [Full Text] [PDF]  

Jessica E. van Montfoort, Michael Müller, Geny M. M. Groothuis, Dirk K. F. Meijer, Hermann Koepsell, and Peter J. Meier

Comparison of "Type I" and "Type II" Organic Cation Transport by Organic Cation Transporters and Organic Anion-Transporting Polypeptides
J Pharmacol Exp Ther 2001 298: 110-115. [Abstract] [Full Text] [PDF]  

Laurent Vernhet, Marie-Pascale Séité, Nathalie Allain, André Guillouzo, and Olivier Fardel

Arsenic Induces Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) Gene in Primary Rat and Human Hepatocytes
J Pharmacol Exp Ther 2001 298: 234-239. [Abstract] [Full Text] [PDF]  

Daisuke Sugiyama, Hiroyuki Kusuhara, Yoshihisa Shitara, Takaaki Abe, Peter J. Meier, Takashi Sekine, Hitoshi Endou, Hiroshi Suzuki, and Yuichi Sugiyama

Characterization of the Efflux Transport of 17-Estradiol-D-17-glucuronide from the Brain across the Blood-Brain Barrier
J Pharmacol Exp Ther 2001 298: 316-322. [Abstract] [Full Text] [PDF]  

Jerome H. Hochman, Masato Chiba, Masayo Yamazaki, Cuyue Tang, and Jiunn H. Lin

P-glycoprotein-Mediated Efflux of Indinavir Metabolites in Caco-2 Cells Expressing Cytochrome P450 3A4
J Pharmacol Exp Ther 2001 298: 323-330. [Abstract] [Full Text] [PDF]  

Tomomi Hatanaka, Kayoko Ihara, Masaaki Kodera, Kazunori Katayama, and Tamotsu Koizumi

Stereoselective Pharmacokinetics and Pharmacodynamics of Organic Nitrates in Rats
J Pharmacol Exp Ther 2001 298: 346-353. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Patricia Andrade-Gordon, Claudia K. Derian, Bruce E. Maryanoff, Han-Cheng Zhang, Michael F. Addo, Wai-man Cheung, Bruce P. Damiano, Michael R. D'Andrea, Andrew L. Darrow, Lawrence de Garavilla, Annette J. Eckardt, Edward C. Giardino, Barbara J. Haertlein, and David F. McComsey

Administration of a Potent Antagonist of Protease-Activated Receptor-1 (PAR-1) Attenuates Vascular Restenosis Following Balloon Angioplasty in Rats
J Pharmacol Exp Ther 2001 298: 34-42. [Abstract] [Full Text] [PDF]  

Yusaku Iwamoto, Keifu Song, Shinji Takai, Mayumi Yamada, Denan Jin, Masato Sakaguchi, Haruhiko Ueda, Yoji Katsuoka, and Mizuo Miyazaki

Multiple Pathways of Angiotensin I Conversion and Their Functional Role in the Canine Penile Corpus Cavernosum
J Pharmacol Exp Ther 2001 298: 43-48. [Abstract] [Full Text] [PDF]  

P. Gohlke, S. Weiss, A. Jansen, W. Wienen, J. Stangier, W. Rascher, J. Culman, and T. Unger

AT₁ Receptor Antagonist Telmisartan Administered Peripherally Inhibits Central Responses to Angiotensin II in Conscious Rats
J Pharmacol Exp Ther 2001 298: 62-70. [Abstract] [Full Text] [PDF]  

Toshio Obata, Shunichiro Kubota, and Yasumitsu Yamanaka

Histamine Increases Interstitial Adenosine Concentration via Activation of Ecto-5'-nucleotidase in Rat Hearts in Vivo
J Pharmacol Exp Ther 2001 298: 71-76. [Abstract] [Full Text] [PDF]  

Min-Liang Si and Tony J. F. Lee

Presynaptic ₇-Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Nitric Oxidergic Neurogenic Vasodilation in Porcine Basilar Arteries
J Pharmacol Exp Ther 2001 298: 122-128. [Abstract] [Full Text] [PDF]  

Jiale He, Yuhui Xiao, and Lubo Zhang

Cocaine-Mediated Apoptosis in Bovine Coronary Artery Endothelial Cells: Role of Nitric Oxide
J Pharmacol Exp Ther 2001 298: 180-187. [Abstract] [Full Text] [PDF]  

Zhu-Shan Zhang, Heng-Jie Cheng, Tomohiko Ukai, Hideo Tachibana, and Che-Ping Cheng

Enhanced Cardiac L-Type Calcium Current Response to ₂-Adrenergic Stimulation in Heart Failure
J Pharmacol Exp Ther 2001 298: 188-196. [Abstract] [Full Text] [PDF]  

Zhenhai Gao, Zhihe Li, Stephen P. Baker, Robert D. Lasley, Stephanie Meyer, Elfatih Elzein, Venkata Palle, Jeff A. Zablocki, Brent Blackburn, and Luiz Belardinelli

Novel Short-Acting A_2A Adenosine Receptor Agonists for Coronary Vasodilation: Inverse Relationship between Affinity and Duration of Action of A_2A Agonists
J Pharmacol Exp Ther 2001 298: 209-218. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Andrew Alt, Iain J. McFadyen, Charles D. Fan, James H. Woods, and John R. Traynor

Stimulation of Guanosine-5'-O-(3-[³⁵S]thio)triphosphate Binding in Digitonin-Permeabilized C6 Rat Glioma Cells: Evidence for an Organized Association of µ-Opioid Receptors and G Protein
J Pharmacol Exp Ther 2001 298: 116-121. [Abstract] [Full Text] [PDF]  

S. Carnesecchi, Y. Schneider, J. Ceraline, B. Duranton, F. Gosse, N. Seiler, and F. Raul

Geraniol, a Component of Plant Essential Oils, Inhibits Growth and Polyamine Biosynthesis in Human Colon Cancer Cells
J Pharmacol Exp Ther 2001 298: 197-200. [Abstract] [Full Text] [PDF]  

Diane P. Naselsky, Daryl Ashton, Robert R. Ruffolo, Jr., and J. Paul Hieble

Rabbit ₂-Adrenoceptors: Both Platelets and Adipocytes Have _2A-Pharmacology
J Pharmacol Exp Ther 2001 298: 219-225. [Abstract] [Full Text] [PDF]  

Nancy A. Martin, Maguerite T. Terruso, and Paul L. Prather

Agonist Activity of the -Antagonists TIPP and TIPP- in Cellular Models Expressing Endogenous or Transfected -Opioid Receptors
J Pharmacol Exp Ther 2001 298: 240-248. [Abstract] [Full Text] [PDF]  

Mubarack M. Muthalif, Farid Ljuca, J. Brent Roaten, Neelu Pentapaty, Mohammed R. Uddin, and Kafait U. Malik

Ca²⁺/Calmodulin-Dependent Protein Kinase II and Cytosolic Phospholipase A₂ Contribute to Mitogenic Signaling in Myeloblastic Leukemia U-937 Cells
J Pharmacol Exp Ther 2001 298: 272-278. [Abstract] [Full Text] [PDF]  

S. Fatima, Z. Khandekar, J.-H. Parmentier, and Kufait U. Malik

Cytosolic Phospholipase A₂ Activation by the p38 Kinase Inhibitor SB203580 in Rabbit Aortic Smooth Muscle Cells
J Pharmacol Exp Ther 2001 298: 331-338. [Abstract] [Full Text] [PDF]  

Julie E. Ruscoe, Lilliam A. Rosario, Tieli Wang, Laurent Gaté, Pinar Arifoglu, C. Roland Wolf, Colin J. Henderson, Ze'ev Ronai, and Kenneth D. Tew

Pharmacologic or Genetic Manipulation of Glutathione S-Transferase P1-1 (GST) Influences Cell Proliferation Pathways
J Pharmacol Exp Ther 2001 298: 339-345. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Daohong Zhou, Christopher M. Lauderback, Tao Yu, Stephen A. Brown, D. Allan Butterfield, and John S. Thompson

D609 Inhibits Ionizing Radiation-Induced Oxidative Damage by Acting as a Potent Antioxidant
J Pharmacol Exp Ther 2001 298: 103-109. [Abstract] [Full Text] [PDF]  

Qiwei Zhang, David W. Ohannesian, Emiko L. Kreklau, and Leonard C. Erickson

Modulation of 1,3-Bis-(2-chloroethyl)-1-nitrosourea Resistance in Human Tumor Cells Using Hammerhead Ribozymes Designed to Degrade O⁶-Methylguanine DNA Methyltransferase mRNA
J Pharmacol Exp Ther 2001 298: 141-147. [Abstract] [Full Text] [PDF]  

Raymond M. Schiffelers, Gert Storm, Marian T. ten Kate, Lorna E. T. Stearne-Cullen, Jan G. den Hollander, Henri A. Verbrugh, and Irma A. J. M. Bakker-Woudenberg

In Vivo Synergistic Interaction of Liposome-Coencapsulated Gentamicin and Ceftazidime
J Pharmacol Exp Ther 2001 298: 369-375. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Se-Ne Huang and Peter W. Swaan

Riboflavin Uptake in Human Trophoblast-Derived BeWo Cell Monolayers: Cellular Translocation and Regulatory Mechanisms
J Pharmacol Exp Ther 2001 298: 264-271. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Kevin Connolly, Yun Hee Cho, Roxanne Duan, James Fikes, Theresa Gregorio, David W. LaFleur, Zebedee Okoye, Theodora W. Salcedo, Gemma Santiago, Stephen Ullrich, Ping Wei, Kathleen Windle, Eling Wong, Xiao-Tao Yao, Ya-Qin Zhang, Grace Zheng, and Paul A. Moore

In Vivo Inhibition of Fas Ligand-Mediated Killing by TR6, a Fas Ligand Decoy Receptor
J Pharmacol Exp Ther 2001 298: 25-33. [Abstract] [Full Text] [PDF]  

Toby J. Toward and Kenneth J. Broadley

Chronic Lipopolysaccharide Exposure on Airway Function, Cell Infiltration, and Nitric Oxide Generation in Conscious Guinea Pigs: Effect of Rolipram and Dexamethasone
J Pharmacol Exp Ther 2001 298: 298-306. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Stephen B. Phagoo, Krisanavane Reddi, Kathryn D. Anderson, L. M. Fredrik Leeb-Lundberg, and David Warburton

Bradykinin B1 Receptor Up-Regulation by Interleukin-1 and B1 Agonist Occurs through Independent and Synergistic Intracellular Signaling Mechanisms in Human Lung Fibroblasts
J Pharmacol Exp Ther 2001 298: 77-85. [Abstract] [Full Text] [PDF]  

Ryan J. Hansen and Joseph P. Balthasar

Pharmacokinetics, Pharmacodynamics, and Platelet Binding of an Anti-Glycoprotein IIb/IIIa Monoclonal Antibody (7E3) in the Rat: A Quantitative Rat Model of Immune Thrombocytopenic Purpura
J Pharmacol Exp Ther 2001 298: 165-171. [Abstract] [Full Text] [PDF]  

Lenard M. Lichtenberger, Jimmy J. Romero, Winanda M. J. de Ruijter, Fariba Behbod, Rebecca Darling, Anis Q. Ashraf, and Sudershan K. Sanduja

Phosphatidylcholine Association Increases the Anti-Inflammatory and Analgesic Activity of Ibuprofen in Acute and Chronic Rodent Models of Joint Inflammation: Relationship to Alterations in Bioavailability and Cyclooxygenase-Inhibitory Potency
J Pharmacol Exp Ther 2001 298: 279-287. [Abstract] [Full Text] [PDF]  

Minako Tsurita, Masahiko Kurokawa, Masami Imakita, Yoshiko Fukuda, Yukio Watanabe, and Kimiyasu Shiraki

Early Augmentation of Interleukin (IL)-12 Level in the Airway of Mice Administered Orally with Clarithromycin or Intranasally with IL-12 Results in Alleviation of Influenza Infection
J Pharmacol Exp Ther 2001 298: 362-368. [Abstract] [Full Text] [PDF]  

James R. Burke, Lynda B. Davern, Paul L. Stanley, Kurt R. Gregor, Jacques Banville, Roger Remillard, John W. Russell, Patrick J. Brassil, Mark R. Witmer, Graham Johnson, Jeffrey A. Tredup, and Kenneth M. Tramposch

BMS-229724 Is a Tight-Binding Inhibitor of Cytosolic Phospholipase A₂ That Acts at the Lipid/Water Interface and Possesses Anti-Inflammatory Activity in Skin Inflammation Models
J Pharmacol Exp Ther 2001 298: 376-385. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Sandrine Bertrand, Gordon Y. K. Ng, Maya Gadhvi Purisai, Shannyn E. Wolfe, Mathew W. Severidt, Dominique Nouel, Richard Robitaille, Malcolm J. Low, Gary P. O'Neill, Kathleen Metters, Jean-Claude Lacaille, Bibie M. Chronwall, and Stephen J. Morris

The Anticonvulsant, Antihyperalgesic Agent Gabapentin Is an Agonist at Brain -Aminobutyric Acid Type B Receptors Negatively Coupled to Voltage-Dependent Calcium Channels
J Pharmacol Exp Ther 2001 298: 15-24. [Abstract] [Full Text] [PDF]  

Polly J. Baumbarger, Mark Muhlhauser, Jin Zhai, Charles R. Yang, and Eric S. Nisenbaum

Positive Modulation of -Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) Receptors in Prefrontal Cortical Pyramidal Neurons by a Novel Allosteric Potentiator
J Pharmacol Exp Ther 2001 298: 86-102. [Abstract] [Full Text] [PDF]  

Heather L. Kimmel, Andrew R. Joyce, F. Ivy Carroll, and Michael J. Kuhar

Dopamine D1 and D2 Receptors Influence Dopamine Transporter Synthesis and Degradation in the Rat
J Pharmacol Exp Ther 2001 298: 129-140. [Abstract] [Full Text] [PDF]  

Rebecca J. Ralph, Martin P. Paulus, and Mark A. Geyer

Strain-Specific Effects of Amphetamine on Prepulse Inhibition and Patterns of Locomotor Behavior in Mice
J Pharmacol Exp Ther 2001 298: 148-155. [Abstract] [Full Text] [PDF]  

David A. White and Stephen G. Holtzman

Acute Opioid Pretreatment Potentiates Naltrexone-Induced Drinking Suppression in Water-Deprived Rats
J Pharmacol Exp Ther 2001 298: 156-164. [Abstract] [Full Text] [PDF]  

Steven B. Harrod, Linda P. Dwoskin, Peter A. Crooks, Jennifer E. Klebaur, and Michael T. Bardo

Lobeline Attenuates d-Methamphetamine Self-Administration in Rats
J Pharmacol Exp Ther 2001 298: 172-179. [Abstract] [Full Text] [PDF]  

Gerhard Hapfelmeier, Rainer Haseneder, Eberhard Kochs, Michaela Beyerle, and Walter Zieglgänsberger

Coadministered Nitrous Oxide Enhances the Effect of Isoflurane on GABAergic Transmission by an Increase in Open-Channel Block
J Pharmacol Exp Ther 2001 298: 201-208. [Abstract] [Full Text] [PDF]  

Jennifer L. Cornish, Mistu Nakamura, and Peter W. Kalivas

Dopamine-Independent Locomotion Following Blockade of N-Methyl-D-aspartate Receptors in the Ventral Tegmental Area
J Pharmacol Exp Ther 2001 298: 226-233. [Abstract] [Full Text] [PDF]  

Toshio Matsuda, Naohisa Arakawa, Kazuhiro Takuma, Yoko Kishida, Yasushi Kawasaki, Masaki Sakaue, Kenzo Takahashi, Teisuke Takahashi, Taizo Suzuki, Tomomi Ota, Akiko Hamano-Takahashi, Michihito Onishi, Yu Tanaka, Kazuya Kameo, and Akemichi Baba

SEA0400, a Novel and Selective Inhibitor of the Na⁺-Ca²⁺ Exchanger, Attenuates Reperfusion Injury in the in Vitro and in Vivo Cerebral Ischemic Models
J Pharmacol Exp Ther 2001 298: 249-256. [Abstract] [Full Text] [PDF]  

A. Kalra, M. O. Urban, and K. A. Sluka

Blockade of Opioid Receptors in Rostral Ventral Medulla Prevents Antihyperalgesia Produced by Transcutaneous Electrical Nerve Stimulation (TENS)
J Pharmacol Exp Ther 2001 298: 257-263. [Abstract] [Full Text] [PDF]  

Richard M. Allen and Linda A. Dykstra

N-Methyl-D-Aspartate Receptor Antagonists Potentiate the Antinociceptive Effects of Morphine in Squirrel Monkeys
J Pharmacol Exp Ther 2001 298: 288-297. [Abstract] [Full Text] [PDF]  

William L. Rumsey, David Aharony, Russell A. Bialecki, Brian M. Abbott, Herbert G. Barthlow, Robert Caccese, Smita Ghanekar, David Lengel, Michelle McCarthy, Barbara Wenrich, Bradley Undem, Cyrus Ohnmacht, Ashok Shenvi, Jeffrey S. Albert, Fred Brown, Peter R. Bernstein, and Keith Russell

Pharmacological Characterization of ZD6021: A Novel, Orally Active Antagonist of the Tachykinin Receptors
J Pharmacol Exp Ther 2001 298: 307-315. [Abstract] [Full Text] [PDF]  

Hidetoshi Yamaguchi, Ryoi Tamura, Jun-Ichi Kuriwaki, Satoshi Eifuku, and Taketoshi Ono

Effects of T-588, a Cognitive Enhancer Compound, on Synaptic Plasticity in the Dentate Gyrus of Freely Moving Rats
J Pharmacol Exp Ther 2001 298: 354-361. [Abstract] [Full Text] [PDF]  

Bart A. Ellenbroek, Jean-François Liégeois, Jacques Bruhwyler, and Alexander R. Cools

Effects of JL13, a Pyridobenzoxazepine with Potential Atypical Antipsychotic Activity, in Animal Models for Schizophrenia
J Pharmacol Exp Ther 2001 298: 386-391. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Contribution of P-glycoprotein to the enhancing effects of dimethyl--cyclodextrin on oral bioavailability of tacrolimus"
J Pharmacol Exp Ther 2001 298: 392. [Full Text] [PDF]  

Correction to "Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum"
J Pharmacol Exp Ther 2001 298: 393. [Full Text] [PDF]  

Correction to "Effect of capillary efflux transport inhibition on the determination of probe recovery during in vivo microdialysis in the brain"
J Pharmacol Exp Ther 2001 298: 393. [Full Text] [PDF]  

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