2001 TORALD SOLLMANN AWARD LECTURE:

Benedict R. Lucchesi

Looking Toward the Future, Using Lessons from the Past
J Pharmacol Exp Ther 2001 297: 829-836. [Abstract] [Full Text] [PDF]  

PERSPECTIVES IN PHARMACOLOGY:

Huailing Zhong and Richard R. Neubig

Regulator of G Protein Signaling Proteins: Novel Multifunctional Drug Targets
J Pharmacol Exp Ther 2001 297: 837-845. [Abstract] [Full Text] [PDF]  

Michael G. Bankson and Kathryn A. Cunningham

3,4-Methylenedioxymethamphetamine (MDMA) as a Unique Model of Serotonin Receptor Function and Serotonin-Dopamine Interactions
J Pharmacol Exp Ther 2001 297: 846-852. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Naoki Kobayashi, Takeshi Kuramoto, Kiyoshi Yamaoka, Mitsuru Hashida, and Yoshinobu Takakura

Hepatic Uptake and Gene Expression Mechanisms following Intravenous Administration of Plasmid DNA by Conventional and Hydrodynamics-Based Procedures
J Pharmacol Exp Ther 2001 297: 853-860. [Abstract] [Full Text] [PDF]  

Haiying Sun, Peter M. Bungay, and William F. Elmquist

Effect of Capillary Efflux Transport Inhibition on the Determination of Probe Recovery During in Vivo Microdialysis in the Brain
J Pharmacol Exp Ther 2001 297: 991-1000. [Abstract] [Full Text] [PDF]  

Kaoru Ueda, Yukio Kato, Kanji Komatsu, and Yuichi Sugiyama

Inhibition of Biliary Excretion of Methotrexate by Probenecid in Rats: Quantitative Prediction of Interaction from in Vitro Data
J Pharmacol Exp Ther 2001 297: 1036-1043. [Abstract] [Full Text] [PDF]  

Barbara J. Ring, James A. Eckstein, Jennifer S. Gillespie, Shelly N. Binkley, Mark VandenBranden, and Steven A. Wrighton

Identification of the Human Cytochromes P450 Responsible for in Vitro Formation of R- and S-Norfluoxetine
J Pharmacol Exp Ther 2001 297: 1044-1050. [Abstract] [Full Text] [PDF]  

R. Blake Pepinsky, Doreen J. LePage, Alan Gill, Abhijit Chakraborty, Sujata Vaidyanathan, Marie Green, Darren P. Baker, Eric Whalley, Paula S. Hochman, and Pauline Martin

Improved Pharmacokinetic Properties of a Polyethylene Glycol-Modified Form of Interferon--1a with Preserved in Vitro Bioactivity
J Pharmacol Exp Ther 2001 297: 1059-1066. [Abstract] [Full Text] [PDF]  

William A. Banks, Susan A. Farr, Waseem Butt, Vijaya B. Kumar, Mark W. Franko, and John E. Morley

Delivery across the Blood-Brain Barrier of Antisense Directed against Amyloid : Reversal of Learning and Memory Deficits in Mice Overexpressing Amyloid Precursor Protein
J Pharmacol Exp Ther 2001 297: 1113-1121. [Abstract] [Full Text] [PDF]  

Mizuho Tanabe, Ichiro Ieiri, Naoki Nagata, Kazuko Inoue, Soichiro Ito, Yasunobu Kanamori, Masakuni Takahashi, Yasuo Kurata, Junzo Kigawa, Shun Higuchi, Naoki Terakawa, and Kenji Otsubo

Expression of P-glycoprotein in Human Placenta: Relation to Genetic Polymorphism of the Multidrug Resistance (MDR)-1 Gene
J Pharmacol Exp Ther 2001 297: 1137-1143. [Abstract] [Full Text] [PDF]  

Kunihiro Yoshisue, Sekio Nagayama, Takashi Shindo, and Yasuro Kawaguchi

Effects of 5-Fluorouracil on the Drug-Metabolizing Enzymes of the Small Intestine and the Consequent Drug Interaction with Nifedipine in Rats
J Pharmacol Exp Ther 2001 297: 1166-1175. [Abstract] [Full Text] [PDF]  

Poh-Gek Forkert, Stephanie M. Boyd, and Judith B. Ulreich

Pulmonary Bioactivation of 1,1-Dichloroethylene Is Associated with CYP2E1 Levels in A/J, CD-1, and C57BL/6 Mice
J Pharmacol Exp Ther 2001 297: 1193-1200. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

M. R. Karamsetty, J. R. Klinger, and N. S. Hill

Phytoestrogens Restore Nitric Oxide-Mediated Relaxation in Isolated Pulmonary Arteries from Chronically Hypoxic Rats
J Pharmacol Exp Ther 2001 297: 968-974. [Abstract] [Full Text] [PDF]  

Carla Bazzani, Salvatore Guarini, Annibale R. Botticelli, Davide Zaffe, Aldo Tomasi, Anna Bini, Maria Michela Cainazzo, Giuseppe Ferrazza, Chiara Mioni, and Alfio Bertolini

Protective Effect of Melanocortin Peptides in Rat Myocardial Ischemia
J Pharmacol Exp Ther 2001 297: 1082-1087. [Abstract] [Full Text] [PDF]  

D. Zheng, R. N. Upton, G. L. Ludbrook, and A. Martinez

Acute Cardiovascular Effects of Magnesium and Their Relationship to Systemic and Myocardial Magnesium Concentrations after Short Infusion in Awake Sheep
J Pharmacol Exp Ther 2001 297: 1176-1183. [Abstract] [Full Text] [PDF]  

Gary J. Grover, Albert J. D'Alonzo, Keith D. Garlid, Robert Bajgar, Nicholas J. Lodge, Paul G. Sleph, Raymond B. Darbenzio, Thomas A. Hess, Mark A. Smith, Petr Paucek, and Karnail S. Atwal

Pharmacologic Characterization of BMS-191095, a Mitochondrial K_ATP Opener with No Peripheral Vasodilator or Cardiac Action Potential Shortening Activity
J Pharmacol Exp Ther 2001 297: 1184-1192. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Daisuke Nakai, Rie Nakagomi, Yoshitake Furuta, Taro Tokui, Takaaki Abe, Toshihiko Ikeda, and Kenji Nishimura

Human Liver-Specific Organic Anion Transporter, LST-1, Mediates Uptake of Pravastatin by Human Hepatocytes
J Pharmacol Exp Ther 2001 297: 861-867. [Abstract] [Full Text] [PDF]  

Noriyuki Shiroshita, Manabu Musashi, Keisuke Sakurada, Kazuhiro Kimura, Yuzo Tsuda, Shuichi Ota, Hiroshi Iwasaki, Tamotsu Miyazaki, Takashi Kato, Hiroshi Miyazaki, Akihiro Shimosaka, and Masahiro Asaka

Involvement of Protein Kinase C- in Signal Transduction of Thrombopoietin in Enhancement of Interleukin-3-Dependent Proliferation of Primitive Hematopoietic Progenitors
J Pharmacol Exp Ther 2001 297: 868-875. [Abstract] [Full Text] [PDF]  

Kenda L. J. Evans, Jodie D. Cropper, Kelly A. Berg, and William P. Clarke

Mechanisms of Regulation of Agonist Efficacy at the 5-HT_1A Receptor by Phospholipid-Derived Signaling Components
J Pharmacol Exp Ther 2001 297: 1025-1035. [Abstract] [Full Text] [PDF]  

Karen S. Mark, William J. Trickler, and Donald W. Miller

Tumor Necrosis Factor- Induces Cyclooxygenase-2 Expression and Prostaglandin Release in Brain Microvessel Endothelial Cells
J Pharmacol Exp Ther 2001 297: 1051-1058. [Abstract] [Full Text] [PDF]  

Medhane G. Cumbay and Val J. Watts

Heterologous Sensitization of Recombinant Adenylate Cyclases by Activation of D₂ Dopamine Receptors
J Pharmacol Exp Ther 2001 297: 1201-1209. [Abstract] [Full Text] [PDF]  

Roland Seifert, Katharina Wenzel-Seifert, Ulrik Gether, and Brian K. Kobilka

Functional Differences between Full and Partial Agonists: Evidence for Ligand-Specific Receptor Conformations
J Pharmacol Exp Ther 2001 297: 1218-1226. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Kathryn W. Woodburn

Intracellular Localization of the Radiation Enhancer Motexafin Gadolinium Using Interferometric Fourier Fluorescence Microscopy
J Pharmacol Exp Ther 2001 297: 888-894. [Abstract] [Full Text] [PDF]  

Hongxie Shen, Zhijian J. Chen, Jack T. Zilfou, Elizabeth Hopper, Maureen Murphy, and Kenneth D. Tew

Binding of the Aminothiol WR-1065 to Transcription Factors Influences Cellular Response to Anticancer Drugs
J Pharmacol Exp Ther 2001 297: 1067-1073. [Abstract] [Full Text] [PDF]  

Kevin O. Hicks, Frederik B. Pruijn, Bruce C. Baguley, and William R. Wilson

Extravascular Transport of the DNA Intercalator and Topoisomerase Poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): Diffusion and Metabolism in Multicellular Layers of Tumor Cells
J Pharmacol Exp Ther 2001 297: 1088-1098. [Abstract] [Full Text] [PDF]  

Javier G. Blanco, Roberto R. Gil, José L. Bocco, Tamara L. Meragelman, Susana Genti-Raimondi, and Alfredo Flury

Aromatase Inhibition by an 11,13-Dihydroderivative of a Sesquiterpene Lactone
J Pharmacol Exp Ther 2001 297: 1099-1105. [Abstract] [Full Text] [PDF]  

Maria F. Dominguez, Rocio I. R. Macias, Irantzu Izco-Basurko, Antonio de la Fuente, Maria J. Pascual, Jose M. Criado, Maria J. Monte, Javier Yajeya, and Jose J. G. Marin

Low in Vivo Toxicity of a Novel Cisplatin-Ursodeoxycholic Derivative (Bamet-UD2) with Enhanced Cytostatic Activity versus Liver Tumors
J Pharmacol Exp Ther 2001 297: 1106-1112. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Naoki Itabashi, Koji Okada, Shigeaki Muto, Nobuya Fujita, Takeshi Ohta, Jun-ichi Miyazaki, Yasushi Asano, and Toshikazu Saito

A Novel Enhancer of Insulinotrophic Action by High Glucose (JTT-608) Stimulates Insulin Secretion from Pancreatic -Cells via a New Cellular Mechanism
J Pharmacol Exp Ther 2001 297: 953-960. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Gang Yue, Pi-Shiang Lai, Kingsley Yin, Frank F. Sun, Robert G. Nagele, Xiao Liu, Kersti K. Linask, Congli Wang, King-Teh Lin, and Patrick Y-K. Wong

Colon Epithelial Cell Death in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis Is Associated with Increased Inducible Nitric-Oxide Synthase Expression and Peroxynitrite Production
J Pharmacol Exp Ther 2001 297: 915-925. [Abstract] [Full Text] [PDF]  

Yoshiyuki Ishiura, Mitsuharu Yoshiyama, Osamu Yokoyama, Mikio Namiki, and William C. de Groat

Central Muscarinic Mechanisms Regulating Voiding in Rats
J Pharmacol Exp Ther 2001 297: 933-939. [Abstract] [Full Text] [PDF]  

Eckhard Beubler, Rufina Schuligoi, Ashok K. Chopra, Deborah A. Ribardo, and Bernhard A. Peskar

Cholera Toxin Induces Prostaglandin Synthesis via Post-Transcriptional Activation of Cyclooxygenase-2 in the Rat Jejunum
J Pharmacol Exp Ther 2001 297: 940-945. [Abstract] [Full Text] [PDF]  

Nobuyuki Katayama, Masaki Fujimura, Akihito Ueda, Toshiyuki Kita, Miki Abo, Hideki Tachibana, Shigeharu Myou, and Kazuyoshi Kurashima

Effects of Carbocysteine on Antigen-Induced Increases in Cough Sensitivity and Bronchial Responsiveness in Guinea Pigs
J Pharmacol Exp Ther 2001 297: 975-980. [Abstract] [Full Text] [PDF]  

K. Gyires and A. Z. Rónai

Supraspinal - and µ-Opioid Receptors Mediate Gastric Mucosal Protection in the Rat
J Pharmacol Exp Ther 2001 297: 1010-1015. [Abstract] [Full Text] [PDF]  

Yael Azriel and Elizabeth Burcher

Characterization and Autoradiographic Localization of Neurotensin Binding Sites in Human Sigmoid Colon
J Pharmacol Exp Ther 2001 297: 1074-1081. [Abstract] [Full Text] [PDF]  

Denise Hammond-McKibben, Philip Lake, Jin Zhang, Nicole Tart-Risher, Ronald Hugo, and Marla Weetall

A High-Capacity Quantitative Mouse Model of Drug-Mediated Immunosuppression Based on Rejection of an Allogeneic Subcutaneous Tumor
J Pharmacol Exp Ther 2001 297: 1144-1151. [Abstract] [Full Text] [PDF]  

Darakhshanda Shehnaz, Khurram Z. Ansari, and Frederick J. Ehlert

Acetylcholine-Induced Desensitization of the Contractile Response to Histamine in Guinea Pig Ileum Is Prevented by Either Pertussis Toxin Treatment or by Selective Inactivation of Muscarinic M₃ Receptors
J Pharmacol Exp Ther 2001 297: 1152-1159. [Abstract] [Full Text] [PDF]  

Koji Takeuchi, Hideo Araki, Masakazu Umeda, Yusaku Komoike, and Keizo Suzuki

Adaptive Gastric Cytoprotection Is Mediated by Prostaglandin EP1 Receptors: A Study Using Rats and Knockout Mice
J Pharmacol Exp Ther 2001 297: 1160-1165. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Israel Gotsman, Amir Shlomai, Ruslana Alper, Elazar Rabbani, Dean Engelhardt, and Yaron Ilan

Amelioration of Immune-Mediated Experimental Colitis: Tolerance Induction in the Presence of Preexisting Immunity and Surrogate Antigen Bystander Effect
J Pharmacol Exp Ther 2001 297: 926-932. [Abstract] [Full Text] [PDF]  

Hiroshi Nakase, Kazuichi Okazaki, Yasuhiko Tabata, Suguru Uose, Masaya Ohana, Kazushige Uchida, Toshiki Nishi, Andra's Debreceni, Toshiyuki Itoh, Chiharu Kawanami, Masao Iwano, Yoshito Ikada, and Tsutomu Chiba

An Oral Drug Delivery System Targeting Immune-Regulating Cells Ameliorates Mucosal Injury in Trinitrobenzene Sulfonic Acid-Induced Colitis
J Pharmacol Exp Ther 2001 297: 1122-1128. [Abstract] [Full Text] [PDF]  

Biddanda C. Ponnappa, Indranil Dey, Guang-chou Tu, Feng Zhou, Maria Aini, Qing-na Cao, and Yedy Israel

In Vivo Delivery of Antisense Oligonucleotides in pH-Sensitive Liposomes Inhibits Lipopolysaccharide-Induced Production of Tumor Necrosis Factor- in Rats
J Pharmacol Exp Ther 2001 297: 1129-1136. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Mark J. Millan, Didier Cussac, Graeme Milligan, Craig Carr, Valérie Audinot, Alain Gobert, Franoise Lejeune, Jean-Michel Rivet, Mauricette Brocco, Delphine Duqueyroix, Jean-Paul Nicolas, Jean A. Boutin, and Adrian Newman-Tancredi

Antiparkinsonian Agent Piribedil Displays Antagonist Properties at Native, Rat, and Cloned, Human ₂-Adrenoceptors: Cellular and Functional Characterization
J Pharmacol Exp Ther 2001 297: 876-887. [Abstract] [Full Text] [PDF]  

G. A. R. Mealing, T. H. Lanthorn, D. L. Small, R. J. Murray, K. C. Mattes, T. M. Comas, and P. Morley

Structural Modifications to an N-Methyl-D-aspartate Receptor Antagonist Result in Large Differences in Trapping Block
J Pharmacol Exp Ther 2001 297: 906-914. [Abstract] [Full Text] [PDF]  

Miao-Kun Sun and Daniel L. Alkon

Pharmacological Enhancement of Synaptic Efficacy, Spatial Learning, and Memory through Carbonic Anhydrase Activation in Rats
J Pharmacol Exp Ther 2001 297: 961-967. [Abstract] [Full Text] [PDF]  

Ganesan L. Kamatchi, Marcel E. Durieux, and Carl Lynch, III

Differential Sensitivity of Expressed L-Type Calcium Channels and Muscarinic M₁ Receptors to Volatile Anesthetics in Xenopus Oocytes
J Pharmacol Exp Ther 2001 297: 981-990. [Abstract] [Full Text] [PDF]  

R. J. Lamb and T. U. C. Järbe

Effects of Fluvoxamine on Ethanol-Reinforced Behavior in the Rat
J Pharmacol Exp Ther 2001 297: 1001-1009. [Abstract] [Full Text] [PDF]  

Lana Kantor, G. H. Keikilani Hewlett, Yang Hae Park, Sarah M. Richardson-Burns, Mathew J. Mellon, and Margaret E. Gnegy

Protein Kinase C and Intracellular Calcium Are Required for Amphetamine-Mediated Dopamine Release via the Norepinephrine Transporter in Undifferentiated PC12 Cells
J Pharmacol Exp Ther 2001 297: 1016-1024. [Abstract] [Full Text] [PDF]  

S. M. Sweitzer, P. Schubert, and J. A. DeLeo

Propentofylline, a Glial Modulating Agent, Exhibits Antiallodynic Properties in a Rat Model of Neuropathic Pain
J Pharmacol Exp Ther 2001 297: 1210-1217. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Matthew J. Bartosiewicz, David Jenkins, Sharron Penn, Jennifer Emery, and Alan Buckpitt

Unique Gene Expression Patterns in Liver and Kidney Associated with Exposure to Chemical Toxicants
J Pharmacol Exp Ther 2001 297: 895-905. [Abstract] [Full Text] [PDF]  

Thierry Hauet, Denis Mothes, Jean-Michel Goujon, Michel Carretier, and Michel Eugene

Protective Effect of Polyethylene Glycol against Prolonged Cold Ischemia and Reperfusion Injury: Study in the Isolated Perfused Rat Kidney
J Pharmacol Exp Ther 2001 297: 946-952. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Molecular targets for antiviral agents"
J Pharmacol Exp Ther 2001 297: 1227. [Full Text] [PDF]  

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