PERSPECTIVES IN PHARMACOLOGY:

William R. Lariviere, Elissa J. Chesler, and Jeffrey S. Mogil

Transgenic Studies of Pain and Analgesia: Mutation or Background Genotype?
J Pharmacol Exp Ther 2001 297: 467-473. [Abstract] [Full Text] [PDF]  

Krishnadas Nandagopal, Ted M. Dawson, and Valina L. Dawson

Critical Role for Nitric Oxide Signaling in Cardiac and Neuronal Ischemic Preconditioning and Tolerance
J Pharmacol Exp Ther 2001 297: 474-478. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Hidetoshi Arima, Kiyokazu Yunomae, Fumitoshi Hirayama, and Kaneto Uekama

Contribution of P-glycoprotein to the Enhancing Effects of Dimethyl--cyclodextrin on Oral Bioavailability of Tacrolimus
J Pharmacol Exp Ther 2001 297: 547-555. [Abstract] [Full Text] [PDF]  

Ming Zhou, Zan-Min Song, and Michael S. Lidow

Pharmacokinetics of Cocaine in Maternal and Fetal Rhesus Monkeys at Mid-Gestation
J Pharmacol Exp Ther 2001 297: 556-562. [Abstract] [Full Text] [PDF]  

Susan K. Paulson, Margaret B. Vaughn, Susan M. Jessen, Yvette Lawal, Christopher J. Gresk, Bo Yan, Timothy J. Maziasz, Chyung S. Cook, and Aziz Karim

Pharmacokinetics of Celecoxib after Oral Administration in Dogs and Humans: Effect of Food and Site of Absorption
J Pharmacol Exp Ther 2001 297: 638-645. [Abstract] [Full Text] [PDF]  

Daniel Y. Hung, Ping Chang, Michael Weiss, and Michael S. Roberts

Structure-Hepatic Disposition Relationships for Cationic Drugs in Isolated Perfused Rat Livers: Transmembrane Exchange and Cytoplasmic Binding Process
J Pharmacol Exp Ther 2001 297: 780-789. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Asma Yaghi, Christopher D. Webb, Jeremy A. Scott, Sanjay Mehta, John R. Bend, and David G. McCormack

Cytochrome P450 Metabolites of Arachidonic Acid but Not Cyclooxygenase-2 Metabolites Contribute to the Pulmonary Vascular Hyporeactivity in Rats with Acute Pseudomonas Pneumonia
J Pharmacol Exp Ther 2001 297: 479-488. [Abstract] [Full Text] [PDF]  

Martin J. Quinn, Ross T. Murphy, Michelle Dooley, J. Brendan Foley, and Desmond J. Fitzgerald

Occupancy of the Internal and External Pools of Glycoprotein IIb/IIIa following Abciximab Bolus and Infusion
J Pharmacol Exp Ther 2001 297: 496-500. [Abstract] [Full Text] [PDF]  

Anindya Bhattacharya, Gerald F. Smith, and Marlene L. Cohen

Effect of LY287045, a Thrombin/Trypsin Inhibitor, on Thrombin and Trypsin-Induced Aortic Contraction and Relaxation
J Pharmacol Exp Ther 2001 297: 573-581. [Abstract] [Full Text] [PDF]  

Christophe Junot, Marie-Francoise Gonzales, Eric Ezan, Joel Cotton, Gilles Vazeux, Annie Michaud, Michel Azizi, Stamatia Vassiliou, Athanasios Yiotakis, Pierre Corvol, and Vincent Dive

RXP 407, a Selective Inhibitor of the N-Domain of Angiotensin I-Converting Enzyme, Blocks in Vivo the Degradation of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro with No Effect on Angiotensin I Hydrolysis
J Pharmacol Exp Ther 2001 297: 606-611. [Abstract] [Full Text] [PDF]  

Sinan Cavun, Garth E. Resch, Adam D. Evec, Michelle M. Rapacon-Baker, and William R. Millington

Blockade of Delta Opioid Receptors in the Ventrolateral Periaqueductal Gray Region Inhibits the Fall in Arterial Pressure Evoked by Hemorrhage
J Pharmacol Exp Ther 2001 297: 612-619. [Abstract] [Full Text] [PDF]  

Edwin K. Jackson and William A. Herzer

Regional Vascular Selectivity of Angiotensin II
J Pharmacol Exp Ther 2001 297: 736-745. [Abstract] [Full Text] [PDF]  

Dierk Thomas, Gunnar Wendt-Nordahl, Katja Röckl, Eckhard Ficker, Arthur M. Brown, and Johann Kiehn

High-Affinity Blockade of Human Ether-A-Go-Go-Related Gene Human Cardiac Potassium Channels by the Novel Antiarrhythmic Drug BRL-32872
J Pharmacol Exp Ther 2001 297: 753-761. [Abstract] [Full Text] [PDF]  

Mahidi Mardini, Anastasia S. Mihailidou, Angela Wong, and Helge H. Rasmussen

Cyclosporine and FK506 Differentially Regulate the Sarcolemmal Na⁺-K⁺ Pump
J Pharmacol Exp Ther 2001 297: 804-810. [Abstract] [Full Text] [PDF]  

Bela Szabo, Ulrich Nordheim, and Nathalie Niederhoffer

Effects of Cannabinoids on Sympathetic and Parasympathetic Neuroeffector Transmission in the Rabbit Heart
J Pharmacol Exp Ther 2001 297: 819-826. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Nathalie Morin, Jose-Miguel Lizcano, Emi Fontana, Luc Marti, Fatima Smih, Philippe Rouet, Danielle Prévot, Antonio Zorzano, Mercedes Unzeta, and Christian Carpéné

Semicarbazide-Sensitive Amine Oxidase Substrates Stimulate Glucose Transport and Inhibit Lipolysis in Human Adipocytes
J Pharmacol Exp Ther 2001 297: 563-572. [Abstract] [Full Text] [PDF]  

Seiji Shiraishi, Toshihiko Yanagita, Hideyuki Kobayashi, Yasuhito Uezono, Hiroki Yokoo, Shin-Ichi Minami, Mayumi Takasaki, and Akihiko Wada

Up-Regulation of Cell Surface Sodium Channels by Cyclosporin A, FK506, and Rapamycin in Adrenal Chromaffin Cells
J Pharmacol Exp Ther 2001 297: 657-665. [Abstract] [Full Text] [PDF]  

Jon R. Inglefield, William R. Mundy, and Timothy J. Shafer

Inositol 1,4,5-Triphosphate Receptor-Sensitive Ca²⁺ Release, Store-Operated Ca²⁺ Entry, and cAMP Responsive Element Binding Protein Phosphorylation in Developing Cortical Cells following Exposure to Polychlorinated Biphenyls
J Pharmacol Exp Ther 2001 297: 762-773. [Abstract] [Full Text] [PDF]  

Zhang Yingge, Bai Chunli, Wang Chen, and Zhao Delu

Force Spectroscopy between Acetylcholine and Single Acetylcholinesterase Molecules and the Effects of Inhibitors and Reactivators Studied by Atomic Force Microscopy
J Pharmacol Exp Ther 2001 297: 798-803. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Isabelle Gaou, Miriam Malliti, Marie-Christine Guimont, Philippe Lettéron, Christine Demeilliers, Gilles Peytavin, Claude Degott, Dominique Pessayre, and Bernard Fromenty

Effect of Stavudine on Mitochondrial Genome and Fatty Acid Oxidation in Lean and Obese Mice
J Pharmacol Exp Ther 2001 297: 516-523. [Abstract] [Full Text] [PDF]  

Emiko L. Kreklau, Naili Liu, Zhaohua Li, Kenneth Cornetta, and Leonard C. Erickson

Comparison of Single- Versus Double-Bolus Treatments of O⁶-Benzylguanine for Depletion of O⁶-Methylguanine DNA Methyltransferase (MGMT) Activity in Vivo: Development of a Novel Fluorometric Oligonucleotide Assay for Measurement of Mgmt Activity
J Pharmacol Exp Ther 2001 297: 524-530. [Abstract] [Full Text] [PDF]  

Shilpa R. Shenoy, Barry R. O'Keefe, Anders J. Bolmstedt, Laura K. Cartner, and Michael R. Boyd

Selective Interactions of the Human Immunodeficiency Virus-Inactivating Protein Cyanovirin-N with High-Mannose Oligosaccharides on gp120 and Other Glycoproteins
J Pharmacol Exp Ther 2001 297: 704-710. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Mamoru Kobayashi, Keiko Takeda, Satoshi Murata, Masami Kojima, Masuo Akahane, Yoshihito Inoue, Kenji Kitamura, and Tatsuhiko Kawarabayashi

Pharmacological Characterization of KUR-1246, a Selective Uterine Relaxant
J Pharmacol Exp Ther 2001 297: 666-671. [Abstract] [Full Text] [PDF]  

Catherine Y. Spong, Daniel T. Abebe, Illana Gozes, Douglas E. Brenneman, and Joanna M. Hill

Prevention of Fetal Demise and Growth Restriction in a Mouse Model of Fetal Alcohol Syndrome
J Pharmacol Exp Ther 2001 297: 774-779. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Sutthasinee Poonyachoti, Philip S. Portoghese, and David R. Brown

Pharmacological Evidence for a 7-Benzylidenenaltrexone-Preferring Opioid Receptor Mediating the Inhibitory Actions of Peptidic - and µ-Opioid Agonists on Neurogenic Ion Transport in Porcine Ileal Mucosa
J Pharmacol Exp Ther 2001 297: 672-679. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

S. R. Engel, R. H. Purdy, and K. A. Grant

Characterization of Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone
J Pharmacol Exp Ther 2001 297: 489-495. [Abstract] [Full Text] [PDF]  

Barbara A. Sorg, Na Li, and Wei-Ran Wu

Dopamine D1 Receptor Activation in the Medial Prefrontal Cortex Prevents the Expression of Cocaine Sensitization
J Pharmacol Exp Ther 2001 297: 501-508. [Abstract] [Full Text] [PDF]  

Michael H. Baumann, Richard B. Rothman, John P. Pablo, and Deborah C. Mash

In Vivo Neurobiological Effects of Ibogaine and Its O-Desmethyl Metabolite, 12-Hydroxyibogamine (Noribogaine), in Rats
J Pharmacol Exp Ther 2001 297: 531-539. [Abstract] [Full Text] [PDF]  

Love Linnér, Hanna Endersz, Daniel Öhman, Finn Bengtsson, Martin Schalling, and Torgny H. Svensson

Reboxetine Modulates the Firing Pattern of Dopamine Cells in the Ventral Tegmental Area and Selectively Increases Dopamine Availability in the Prefrontal Cortex
J Pharmacol Exp Ther 2001 297: 540-546. [Abstract] [Full Text] [PDF]  

Jodie J. Rady, Blythe B. Holmes, Leon F. Tseng, and James M. Fujimoto

Inverse Agonist Action of Leu-Enkephalin at ₂-Opioid Receptors Mediates Spinal Antianalgesia
J Pharmacol Exp Ther 2001 297: 582-589. [Abstract] [Full Text] [PDF]  

Robert M. Silva, Maria M. Hadjimarkou, Grace C. Rossi, Gavril W. Pasternak, and Richard J. Bodnar

-Endorphin-Induced Feeding: Pharmacological Characterization Using Selective Opioid Antagonists and Antisense Probes in Rats
J Pharmacol Exp Ther 2001 297: 590-596. [Abstract] [Full Text] [PDF]  

Jennifer L. Wells, Jeffrey L. Bartlett, Subramaniam Ananthan, and Edward J. Bilsky

In Vivo Pharmacological Characterization of SoRI 9409, a Nonpeptidic Opioid µ-Agonist/-Antagonist That Produces Limited Antinociceptive Tolerance and Attenuates Morphine Physical Dependence
J Pharmacol Exp Ther 2001 297: 597-605. [Abstract] [Full Text] [PDF]  

Joseph P. Hodgkiss and John S. Kelly

Effect of FK960, a Putative Cognitive Enhancer, on Synaptic Transmission in CA1 Neurons of Rat Hippocampus
J Pharmacol Exp Ther 2001 297: 620-628. [Abstract] [Full Text] [PDF]  

Sachin Patel and Cecilia J. Hillard

Cannabinoid CB₁ Receptor Agonists Produce Cerebellar Dysfunction in Mice
J Pharmacol Exp Ther 2001 297: 629-637. [Abstract] [Full Text] [PDF]  

Roger L. Papke, Paul R. Sanberg, and R. Douglas Shytle

Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes
J Pharmacol Exp Ther 2001 297: 646-656. [Abstract] [Full Text] [PDF]  

Tracey J. Nickola, Tracey A. Ignatowski, Jessica L. Reynolds, and Robert N. Spengler

Antidepressant Drug-Induced Alterations in Neuron-Localized Tumor Necrosis Factor- mRNA and ₂-Adrenergic Receptor Sensitivity
J Pharmacol Exp Ther 2001 297: 680-687. [Abstract] [Full Text] [PDF]  

Peng Huang, George B. Kehner, Alan Cowan, and Lee-Yuan Liu-Chen

Comparison of Pharmacological Activities of Buprenorphine and Norbuprenorphine: Norbuprenorphine Is a Potent Opioid Agonist
J Pharmacol Exp Ther 2001 297: 688-695. [Abstract] [Full Text] [PDF]  

E. Bradshaw Bunney, Sarah B. Appel, and Mark S. Brodie

Electrophysiological Effects of Cocaethylene, Cocaine, and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area
J Pharmacol Exp Ther 2001 297: 696-703. [Abstract] [Full Text] [PDF]  

Frank I. Tarazi, Kehong Zhang, and Ross J. Baldessarini

Long-Term Effects of Olanzapine, Risperidone, and Quetiapine on Dopamine Receptor Types in Regions of Rat Brain: Implications for Antipsychotic Drug Treatment
J Pharmacol Exp Ther 2001 297: 711-717. [Abstract] [Full Text] [PDF]  

Charles S. Bockman, Michael E. Bradley, Herbert K. Dang, Wanyun Zeng, Margaret A. Scofield, and Frank J. Dowd

Molecular and Pharmacological Characterization of Muscarinic Receptor Subtypes in a Rat Parotid Gland Cell Line: Comparison with Native Parotid Gland
J Pharmacol Exp Ther 2001 297: 718-726. [Abstract] [Full Text] [PDF]  

Kris J. Alden and Jesús García

Differential Effect of Gabapentin on Neuronal and Muscle Calcium Currents
J Pharmacol Exp Ther 2001 297: 727-735. [Abstract] [Full Text] [PDF]  

Changqing Xu and Roh-Yu Shen

Amphetamine Normalizes the Electrical Activity of Dopamine Neurons in the Ventral Tegmental Area following Prenatal Ethanol Exposure
J Pharmacol Exp Ther 2001 297: 746-752. [Abstract] [Full Text] [PDF]  

Hiroyasu Hirose, Ikuo Aoki, Toshifumi Kimura, Toru Fujikawa, Tomoshige Numazawa, Kaori Sasaki, Akio Sato, Takuro Hasegawa, Masaru Nishikibe, Morihiro Mitsuya, Norikazu Ohtake, Toshiaki Mase, and Kazuhito Noguchi

Pharmacological Properties of (2R)-N-[1-(6-Aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2- hydroxy-2-phenylacetamide: A Novel Muscarinic Antagonist with M₂-Sparing Antagonistic Activity
J Pharmacol Exp Ther 2001 297: 790-797. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Laura J. C. Bolchoz, Robert A. Budinsky, David C. McMillan, and David J. Jollow

Primaquine-Induced Hemolytic Anemia: Formation and Hemotoxicity of the Arylhydroxylamine Metabolite 6-Methoxy-8-hydroxylaminoquinoline
J Pharmacol Exp Ther 2001 297: 509-515. [Abstract] [Full Text] [PDF]  

Niel C. Hoglen, Brad P. Hirakawa, Craig D. Fisher, Suzanne Weeks, Anu Srinivasan, Angela M. Wong, Karen L. Valentino, Kevin J. Tomaselli, Xu Bai, Don S. Karanewsky, and Patricia C. Contreras

Characterization of the Caspase Inhibitor IDN-1965 in a Model of Apoptosis-Associated Liver Injury
J Pharmacol Exp Ther 2001 297: 811-818. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "Lalsoacidipine modulates the secretion of matrix metalloproteinase-9 by human macrophages"
J Pharmacol Exp Ther 2001 297: 827. [Full Text] [PDF]  

Correction to "Pharmacokinetics and immunological effects of exogenously administered recombinant human B lymphocyte stimulator (BLyS) in mice"
J Pharmacol Exp Ther 2001 297: 827. [Full Text] [PDF]  

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